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Journal articles on the topic 'In-Vitro Release Kinetics'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kumar, Putta Rajesh, Meena N, Poojitha P, Sowjanya P, Shivaleela U, and Sharma JVC. "Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 51–63. http://dx.doi.org/10.32553/jbpr.v13i2.1084.

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Background: Venlafaxine Hydrochloride a serotonin, nor epinephrine reuptake inhibitor, oral antidepressant used to treat depression. Objective: The present study was aimed at studying controlled release of Venlafaxine Hydrochloride with Guargum, Hydroxy propyl methyl cellulose as matrix polymers, Micro crystalline cellulose as binder and Dicalcium phosphate as diluent filler. Methods: Tablets were studied for pre, post compression, swelling and in vitro dissolution studies. Drug release was analyzed by release kinetic models. Results: Preformulation studies revealed that the drug procured was

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Arefin, Paroma, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres." Bangladesh Pharmaceutical Journal 19, no. 1 (2016): 58–67. http://dx.doi.org/10.3329/bpj.v19i1.29240.

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The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded sustained release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In vitro dissolution study was performed spectrophotometrically according to USP paddle method using phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was significantly increased with the increase of drug loading. The drug release patte

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Jakobek, Lidija, Jozo Ištuk, Andrew R. Barron, and Petra Matić. "Bioactive Phenolic Compounds from Apples during Simulated In Vitro Gastrointestinal Digestion: Kinetics of Their Release." Applied Sciences 13, no. 14 (2023): 8434. http://dx.doi.org/10.3390/app13148434.

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Bioactive phenolic compounds in their natural form show beneficial effects on the gastrointestinal system. The kinetics of their release are important for understanding those effects. The aim was to study the kinetics of the release of phenolic compounds from apples during in vitro simulated gastrointestinal digestion by using modified equations of first- and second-order kinetics. 35% and 67% of total phenolic compounds were released in the gastric phase, and 26% and 27% in the intestinal phase (peel and flesh, respectively). Intensive release of anthocyanins, flavan-3-ols, dihydrochalcones,

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Kabir, Abul Kalam Lutful, Shimul Halder, and Abu Shara Shamsur Rouf. "In vitro Release Kinetic Study of Theophylline from Kollidon SR Polymer Based Matrix Tablet." Dhaka University Journal of Pharmaceutical Sciences 14, no. 1 (2015): 43–48. http://dx.doi.org/10.3329/dujps.v14i1.23734.

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Controlled release tablet matrix of theophylline was prepared with kollidon SR, a spray dried powder grade polymer (polyvinyl acetate and povidone based matrix rate retarding hydrophobic materials) by utilizing direct compression technique. Different proportion of kollidon SR was used to develop the matrix builder in the five proposed formulations (F-1 to F-5) for the study of release rate retardant effect at 10, 12, 15, 18 and 21% of total weight of matrix tablet, respectively. The in vitro dissolution study of the matrices of those proposed tablet formulations were carried out in simulated g

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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

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Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and

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Ruan, Xiangchun, Jidong Hu, Lianshou Lu, et al. "Poloxamer 407/188 Binary Thermosensitive Gel as a Moxidectin Delivery System: In Vitro Release and In Vivo Evaluation." Molecules 27, no. 10 (2022): 3063. http://dx.doi.org/10.3390/molecules27103063.

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Moxidectin (MXD) is an antiparasitic drug used extensively in veterinary clinics. In this study, to develop a new formulation of MXD, a thermosensitive gel of MXD (MXD-TG) was prepared based on poloxamer 407/188. Furthermore, the gelation temperature, the stability, in vitro release kinetics and in vivo pharmacokinetics of MXD-TG were evaluated. The results showed that the gelation temperature was approximately 27 °C. MXD-TG was physically stable and can be released continuously for more than 96 h in vitro. The Korsmeyer–Peppas model provided the best fit to the release kinetics, and the relea

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Dias, Susana, António Mata, João Silveira, et al. "Hydrogen Peroxide Release Kinetics of Four Tooth Whitening Products—In Vitro Study." Materials 14, no. 24 (2021): 7597. http://dx.doi.org/10.3390/ma14247597.

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Tooth whitening efficacy can be influenced by several factors, of which concentration and application time are two of the most important. This in vitro study aimed to evaluate the initial content and release kinetics of the hydrogen peroxide (HP) content, or the carbamide peroxide (CP) content as converted to its HP equivalent, of four tooth whitening products with different concentrations (6% HP, 16% CP, 10% CP, and 5% CP). Titrations with Cerium Sulphate IV were performed to determine HP concentration. HP release kinetics were evaluated by a spectrophotometric technique. The results were exp

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9

Yefimova, S. L. "In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes." Functional materials 22, no. 2 (2015): 199–206. http://dx.doi.org/10.15407/fm22.02.199.

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Shuma, Madhabi Lata, Bishyajit Kumar Biswas, Sheikh Zahir Raihan, and Shimul Halder. "In vitro Comparative Dissolution Studies of Different Propranolol Generic Tablets Available in Bangladesh." Journal of Drug Delivery and Therapeutics 11, no. 6-S (2021): 86–91. http://dx.doi.org/10.22270/jddt.v11i6-s.5225.

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The present study focused to assess in vitro dissolution profiles of four different products of propranolol 10 mg Tablets (Randomly coded as PRP1-PRP4) available in Bangladesh comparing with the reference brand (coded as REF). Propranolol is a competitive non selective beta-adrenergic receptor antagonist used to amend or restore normal heart rhythm in cardiovascular diseases. An in vitro dissolution study was carried out using the United States Pharmacopoeia (USP) paddle method at 75 rpm with 500 mL of 0.1N HCl dissolution media at 37.0± 0.5 0C. All the tested locally manufactured propranolol

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11

Li, Chun Yan, Cong Cong Hu, Zhi Guo Wen, and Sheng Xiong Dong. "The In Vitro Degradation Kinetics of Polyurethane Prodrug Materials." Advanced Materials Research 399-401 (November 2011): 1067–70. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.1067.

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The method of high performance liquid chromatography (HPLC) is established to determine the content of antibacterial agent — ciprofloxacin (CF) in the degradation solution of ciprofloxacin-polyurethane (CFPU) and investigate the in vitro degradation kinetics by plotting and fitting the cumulative release curves to inspect the effects of different medium and different concentrations on drug release. The results showed that the HPLC method is accurate, reliable and simple. The drug-release of CFPU was bioresponsive and could be accorded with first order kinetics. It was observed that CF was rele

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Costa, André Lima de Oliveira, Paula Cristina Rezende Enéas, Tiago Assis Miranda, Sueli Aparecida Mingoti, Cristina Duarte Vianna Soares, and Gerson Antônio Pianetti. "In vitro dissolution kinetic for mycophenolic acid derivatives tablets." Brazilian Journal of Pharmaceutical Sciences 49, no. 2 (2013): 311–19. http://dx.doi.org/10.1590/s1984-82502013000200013.

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Mycophenolate mofetil (MMF) and mycophenolate sodium (MPS) are an ester and a salt of mycophenolic acid. They have different kinetic in vivo characteristics due to differences in molecular structures, physicochemical properties and formulations administered. In this study, dissolution profiles of reference products were tested in different media to evaluate the effect of pH, kinetic dissolution and the best statistical model that can be used to predict the release of both drugs. The drug release was determined by using a validated ultraviolet spectrophotometry method, λ 250 nm. The method show

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Kumar, B., and G. Jeyabalan. "Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide." Indian Journal of Pharmaceutical and Biological Research 5, no. 02 (2017): 24–28. http://dx.doi.org/10.30750/ijpbr.5.2.5.

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Metformin/Gliclazide niosomes were formulated with span 60 by ether injection method. Three batches MG1-MG3 were prepared in order to study influence of drug polymer ratio on the niosomes formation and in vitro drug release. The formulated niosomes were characterized by drug entrapment, vesicle size determination, and in vitro drug release. Optimized concentration of span 60 and cholesterol was found to be 1:1. In the in-vitro study, niosomes formulation of MG1 showed high percentage of drug release, 40.18 to 45.75% for about 8 hrs. This indicated that this batch of niosomes formulation exhibi

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Qaiser, Rasheed* Ghulam Razaque Ghulam Musatafa Shahwani Noman ul Haq Nisar Ahmed Shahwani Shafi Muhammad. "FORMULATION OF CONTROLLED RELEASE DRUG DELIVERY OF LORNOXICAM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 2933–38. https://doi.org/10.5281/zenodo.892233.

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The aim of the present work was to develop controlled release matrix tablets of Lornoxicam using polymers such as carbopol, Eudragit RS100 and ethyl cellulose as carriers in various concentrations. Matrix tablets were prepared by direct compression method. Prepared formulations were subjected to various evaluation parameters like hardness, friability, thickness, % drug content, weight variation etc. In-vitro dissolution studies were carried out for 12 hrs. The tablets were subjected to in-vitro drug release in 1.2 pH for first 2 hrs then followed by 6.8 pH phosphate buffer for next 10 hrs and

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Chakraborty, Sudipta, N. N. Bala, and Sudipta Das. "Development, Evaluation and in vitro Release Kinetics Study of Immediate Release Tablets of Quercetin Isolated from Bauhinia acuminata Leaves Extract." Indian Journal Of Science And Technology 15, no. 46 (2022): 2534–41. http://dx.doi.org/10.17485/ijst/v15i46.1839.

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Debatri, Roy, Das Sudipta, Panda Madhurima, et al. "Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol." Indian Journal of Science and Technology 15, no. 48 (2022): 2690–98. https://doi.org/10.17485/IJST/v15i48.2145.

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Abstract <strong>Objective:</strong> The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount of Carbopol. <strong>Methods:</strong> Formulations (F1, F2 and F3) of Metronidazole in gel form were done in varying amounts of Carbopol. Prepared gels were inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, in vitro process of drug release, release kinetics and stability testing. <strong>Findings:</strong> Formulation pH was placed in between 5 and 6. Measured viscosity

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Mitran, Raul-Augustin, Daniela Berger, Jeanina Pandele-Cusu, and Cristian Matei. "Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics." Journal of Nanomaterials 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/9864396.

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Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small- and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro releas

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Rozas, Rodrigo, Andrea C. Ortiz, Sofía Peñaloza, et al. "Kinetic and Methodological Insights into Hydrophilic Drug Release from Mesoporous Silica Nanocarriers." Pharmaceutics 17, no. 6 (2025): 694. https://doi.org/10.3390/pharmaceutics17060694.

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Background/Objectives: The absence of standardized protocols for assessing in vitro drug release from nanocarriers poses significant challenges in nanoformulation development. This study evaluated three in vitro methods: sample and separate without medium replacement (independent batch), sample and separate with medium replacement, and a dialysis bag method, to characterize the release of rhodamine B from mesoporous silica nanoparticles (MSNs). Methods: Each method was examined under varying agitation conditions (shaking versus stirring). MSNs were synthesized via the sol-gel method, exhibitin

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Sharma, Megha, Seema Kohli, and Abhisek Pal. "PREPARATION AND EVALUATION OF CONTROLLED RELEASE FLOATING MICROSPHERES OF REPAGLINIDE: OPTIMIZATION AND IN-VITRO STUDIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 103. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.15310.

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ABSTRACTObjective: To develop and evaluate floating microspheres of repaglinide (RG).Materials and Methods: RG loaded noneffervescent microspheres of different ratios of ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMCK4M) were prepared using polyvinyl alcohol as emulsifier by solvent evaporation technique. Various process variables such as polymer ratio, stirringspeed, concentration of drug, and emulsifying agent were studied. Compatibility of drug and polymers was studied by Fourier-transform infraredspectroscopy (FTIR). Characterization, in-vitro evaluation, and kinetic studies w

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Illner, Sabine, Stefanie Kohse, Claudia Michaelis, et al. "In vitro study of sirolimus release from nonwoven PLLA matrices." Current Directions in Biomedical Engineering 4, no. 1 (2018): 591–94. http://dx.doi.org/10.1515/cdbme-2018-0142.

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AbstractSirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measuring the drug concentration in an established drug release medium (0.9% saline solution with additives, not buffered) at predetermined time points. Furthermore, an NH3-plasma pretreatment was examined to ensure complete wetting from the beginning of the study. In comparison to thin drug-loaded PLLA spray coatings it was shown that the release of sirolimu

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Parashar, Tarun, Kapil Kalra, Jyoti M. Kalra, et al. "Formulation and In-vitro Evaluation of Bilayer Tablet of Olmesartan Medoxomil for Biphasic Drug Release." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 02 (2023): 388–92. http://dx.doi.org/10.25258/ijpqa.14.2.24.

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Objective: The current study aimed to optimize the bioavailability and absorption of olmesartan in the lower gastrointestinal tract by creating a bilayer tablet for biphasic drug release. Methods: Microcrystalline cellulose was combined and direct compression the requirement for an early response to address an undesirable defect or condition. In the current instance, 5 mg of olmesartan must be released immediately, and the remaining 10 mg of olmesartan must be released gradually to maintain the therapeutic concentration. In order to adjust the release pattern of the olmesartan sustained releas

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Quintal Martínez, Juan Pablo, Jorge Carlos Ruiz Ruiz, and Maira Rubí Segura Campos. "Release Kinetic Studies of Stevia rebaudiana Extract Capsules from Sodium Alginate and Inulin by Ionotropic Gelation." Advances in Materials Science and Engineering 2018 (July 11, 2018): 1–8. http://dx.doi.org/10.1155/2018/6354924.

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This study was oriented towards encapsulation of S. rebaudiana extract and the study of its release kinetics. The desired encapsulation was achieved by the ionotropic gelation method using sodium alginate and inulin of polymeric constituents. Characterization of the capsules was performed by micrometric properties, encapsulation efficiency, in vitro extract release analysis, and biological activity of released extract. The in vitro release profiles from different capsules were applied on different kinetic models. The prepared capsules were found spherical in shape with diameters ranging from 2

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Đekić, Ljiljana, and Ana Ćirić. "Modeling of in vitro drug release from polymeric microparticle carriers." Arhiv za farmaciju 72, no. 6 (2022): 591–620. http://dx.doi.org/10.5937/arhfarm72-40229.

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Incorporation of active substances in polymeric microparticles (microencapsulation) is an important technological strategy used in the pharmaceutical industry to improve the functionality, quality, safety and/or therapeutic efficiency of pharmaceutical preparations for different routes of administration. The current focus of research in this field is on the encapsulation of small molecules and macromolecules into microparticles based on biocompatible synthetic polymers and biopolymers, such as polypeptides and polysaccharides, in order to achieve preferable drug release kinetics and many other

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Iovanov, Rareș Iuliu, Ioan Tomuță, and Sorin Emilian Leucuța. "Development of a reservoir type prolonged release system with felodipine via simplex methodology." Medicine and Pharmacy Reports 89, no. 1 (2015): 128–36. http://dx.doi.org/10.15386/cjmed-526.

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Background and aims. Felodipine is a dihydropyridine calcium antagonist that presents good characteristics to be formulated as prolonged release preparations. The aim of the study was the formulation and in vitro characterization of a reservoir type prolonged release system with felodipine, over a 12 hours period using the Simplex method.Methods. The first step of the Simplex method was to study the influence of the granules coating method on the felodipine release. Furthermore the influence of the coating polymer type, the percent of the coating polymer and the percent of pore forming agent i

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Andreevskaya, SN, TG Smirnova, EN Antonov, et al. "New in vitro model to evaluate kinetics of antimycobacterial drug release from bioresorbable polymeric carriers." MicroRNA in ocular pathology, no. 2020(4) (August 2020): 10–15. http://dx.doi.org/10.24075/brsmu.2020.050.

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Sustained-release drugs against tuberculosis are a promising approach to therapy since they positively affect patient compliance with long regimens, especially when it comes to the multidrug-resistant form of the disease. Conventional UV-visible spectroscopy does not work well with multicomponential culture media used for growing M. tuberculosis. The aim of this study was to develop a method for evaluating the kinetics of anti-tuberculosis drug released from bioresorbable polymeric carriers suitable for screening a wide range of encapsulated prolonged-release drugs and identifying the best per

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Chakraborty, Santanu, Madhusmruti Khandai, Anuradha Sharma, Ch Patra, V. Patro, and Kalyan Sen. "Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations." Acta Pharmaceutica 59, no. 3 (2009): 313–23. http://dx.doi.org/10.2478/v10007-009-0025-8.

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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied.

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Narissara Kulpreechanan and Feuangthit Niyamissara Sorasitthiyanukarn. "Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4555–59. http://dx.doi.org/10.26452/ijrps.v11i3.2685.

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The present aim is to evaluate the release profile and its release kinetics of encapsulated capsaicin from chitosan nanoparticles using the software DDSolver. The release study was performed by using a dialysis technique in PBS solutions with different pHs (1.2, 6.8 and 7.4) to mimics the different gastrointestinal tract and circulatory system pH ranges as a releasing medium. The nanoparticles were prepared using o/w emulsification and ionotropic gelation technique under optimal condition obtained from response surface methodology (RSM) design as described in our previous study. These nanopart

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Rahman, B. M., M. A. Islam, M. I. I. Wahed, et al. "In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices." Journal of Scientific Research 1, no. 2 (2009): 353–62. http://dx.doi.org/10.3329/jsr.v1i2.1080.

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Methocel K15 MCR (a modified hydroxypropylmethylcellulose) matrix tablets of pentoxifylline using microcrystalline cellulose (MCC), starch and lactose were prepared by wet granulation process. There was no significant difference in drug release between the hydrophilic matrices when the Methocel K15 MCR concentration was modified in low percentage. The release of pentoxifylline was influenced by the presence of microcrystalline cellulose, and by the different concentrations of starch and lactose. The data obtained proved that the formulation with 12.5% Methocel K15 MCR and 20% lactose is more u

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Kotharapu, Rama Koteswararao, and Srinivas Lankalapalli. "Development and Evaluation of Clopidogrel Bisulphate Multi-Unit Floating Mini-Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 173–80. http://dx.doi.org/10.22270/jddt.v9i4.3169.

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The objective of the present work was to formulate and characterize multi-unit floating drug delivery system of Clopidogrel bisulphate to increase the bioavailability and sustain the drug release properties up to 8 h with more predictable drug release kinetics that avoids all or nothing emptying effect wherefore to improve patient compliance. Clopidogrel bisulphate floating mini-tablets were prepared by effervescent approach with melt granulation and direct compression techniques alone and in combination using Hydroxypropyl methylcellulose (HPMC) K100M and Compritol 888 ATO at different concen

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Szulc-Musioł, Beata, Lucyna Bułaś, and Barbara Dolińska. "Formulation, characterization, and in vitro evaluation release nimesulide from different rectal suppository bases." Acta Poloniae Pharmaceutica - Drug Research 79, no. 6 (2023): 865–73. http://dx.doi.org/10.32383/appdr/159289.

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Nimesulide is a poorly water-soluble, non-steroidal anti-inflammatory drug for both systemic and topical application. The aim of the study was to assess the influence of the type of base and surfactants (Tween80, Span80, soy lecithin, sodium lauryl sulphate) on drug release from rectal suppositories. Suppositories were prepared in the Unquator® using Cacao butter, Witepsol H15 and PEG1500:PEG400 as a base. The physicochemical properties of the prepared suppositories were in accordance to the Pharmacopoeia’s requirements. In vitro dissolution profile of the formulations was evaluated using USP

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Choi, Yongwhan, Hong Yeol Yoon, Jeongrae Kim, et al. "Doxorubicin-Loaded PLGA Nanoparticles for Cancer Therapy: Molecular Weight Effect of PLGA in Doxorubicin Release for Controlling Immunogenic Cell Death." Pharmaceutics 12, no. 12 (2020): 1165. http://dx.doi.org/10.3390/pharmaceutics12121165.

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Direct local delivery of immunogenic cell death (ICD) inducers to a tumor site is an attractive approach for leading ICD effectively, due to enabling the concentrated delivery of ICD inducers to the tumor site. Herein, we prepared doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) using different molecular weight PLGA (7000 g/mol and 12,000 g/mol), showing different drug release kinetics. The different release kinetics of DOX might differently stimulate a tumor cell-specific immune response by releasing damage-associated molecular patterns (DAMPs), resulting in s

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M., Durgarao*, Lakshmi Kavya G., Bhanu Mallika A.V., Srivinay G., Ravi P., and Lahari V. "FORMULATION AND EVALUATION OF PROLONGED RELEASE GEMFIBROZIL TABLETS." World Journal of Pharmaceutical Science and Research 3, no. 3 (2024): 325–33. https://doi.org/10.5281/zenodo.12732807.

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The development of prolonged-release formulations of pharmaceuticals is essential for enhancing therapeutic efficacy and patient compliance. This study focuses on the formulation and evaluation of prolonged-release Gemfibrozil tablets, a lipid-regulating agent used in the management of hyperlipidemia. The primary objective was to design a tablet that ensures sustained release of Gemfibrozil, thereby maintaining a consistent plasma concentration over an extended period. The formulation process involved the selection of appropriate polymers and excipients to achieve the desired release profile.

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Muqtader, Mohammad* Farhat Fatima Saad Abdullah Alharbi Fahad I. Al-Saikha Saad Maria Alshahrani Ahmed Alalaiwe Abdullah Saud Alshetaili Bader B. Alsulays Abdel-Kader MS Mohammad Javed Ansari Mohammad Khalid Anwer Mohamed Hassan Fayed Prakash Katakam. "DEVELOPMENT AND IN VITRO EVALUATION OF CONTROLLED RELEASE ORAL FLOATING CAPSULES OF CIPROFLOXACIN HYDROCHLORIDE." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3843–48. https://doi.org/10.5281/zenodo.1027975.

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The aim of the present investigation was to develop the ciprofloxacin gastroretentive floating capsules by using hydrophilic rate retarding and swellable polymers. The different concentration and combination of Hydroxy Propyl Methyl Cellulose (HPMC) and carbopol 947P polymers influenced the release of the drug, the swellable matrix retained in the stomach by imbibing the CO2 gas released. The effervescence of CO2 generated by the sodium bicarbonate and citric acid added in 2.70 - 6.0 and 2.70 - 4.0 % w/w respectively except for formulation F4&F8. Formulation F1-F8 were prepared by adding 2

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Chang, Li-Yen, Ali Ar Mohd, Sharifah Syed Hassan, and Sazaly AbuBakar. "Quantitative estimation of Nipah virus replication kinetics in vitro." Virology Journal 3, no. 1 (2006): 47. https://doi.org/10.5281/zenodo.13491575.

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(Uploaded by Plazi for the Bat Literature Project) Background: Nipah virus is a zoonotic virus isolated from an outbreak in Malaysia in 1998. The virus causes infections in humans, pigs, and several other domestic animals. It has also been isolated from fruit bats. The pathogenesis of Nipah virus infection is still not well described. In the present study, Nipah virus replication kinetics were estimated from infection of African green monkey kidney cells (Vero) using the one-step SYBR® Green I-based quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) assay. Results

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Chang, Li-Yen, Ali Ar Mohd, Sharifah Syed Hassan, and Sazaly AbuBakar. "Quantitative estimation of Nipah virus replication kinetics in vitro." Virology Journal 3, no. 1 (2006): 47. https://doi.org/10.5281/zenodo.13491575.

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(Uploaded by Plazi for the Bat Literature Project) Background: Nipah virus is a zoonotic virus isolated from an outbreak in Malaysia in 1998. The virus causes infections in humans, pigs, and several other domestic animals. It has also been isolated from fruit bats. The pathogenesis of Nipah virus infection is still not well described. In the present study, Nipah virus replication kinetics were estimated from infection of African green monkey kidney cells (Vero) using the one-step SYBR® Green I-based quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) assay. Results

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Chang, Li-Yen, Ali Ar Mohd, Sharifah Syed Hassan, and Sazaly AbuBakar. "Quantitative estimation of Nipah virus replication kinetics in vitro." Virology Journal 3, no. 1 (2006): 47. https://doi.org/10.5281/zenodo.13491575.

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(Uploaded by Plazi for the Bat Literature Project) Background: Nipah virus is a zoonotic virus isolated from an outbreak in Malaysia in 1998. The virus causes infections in humans, pigs, and several other domestic animals. It has also been isolated from fruit bats. The pathogenesis of Nipah virus infection is still not well described. In the present study, Nipah virus replication kinetics were estimated from infection of African green monkey kidney cells (Vero) using the one-step SYBR® Green I-based quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) assay. Results

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37

Chang, Li-Yen, Ali Ar Mohd, Sharifah Syed Hassan, and Sazaly AbuBakar. "Quantitative estimation of Nipah virus replication kinetics in vitro." Virology Journal 3, no. 1 (2006): 47. https://doi.org/10.5281/zenodo.13491575.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Background: Nipah virus is a zoonotic virus isolated from an outbreak in Malaysia in 1998. The virus causes infections in humans, pigs, and several other domestic animals. It has also been isolated from fruit bats. The pathogenesis of Nipah virus infection is still not well described. In the present study, Nipah virus replication kinetics were estimated from infection of African green monkey kidney cells (Vero) using the one-step SYBR® Green I-based quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) assay. Results

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Katta, Ashwini1 K. Kishore and Dr. Gampa Vijay Kumar. "DESIGN, CHARACTERIZATION AND IN VITRO EVALUATION OF RIFAXIMIN EFFERVESCENT FLOATING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 16583–90. https://doi.org/10.5281/zenodo.2429621.

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<em>In the present research work effervescent floating formulation of Rifaximin by using various polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate was used. Then the formulation was developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the

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Sangu, Vineela, and Shankaraiah Puligilla. "DEVELOPMENT AND In-vitro EVALUATION OF PALIPERIDONE FLOATING TABLETS USING NATURAL POLYMERS." RASAYAN Journal of Chemistry 17, no. 03 (2024): 826–31. http://dx.doi.org/10.31788/rjc.2024.1738819.

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The present research aim is the formulation and invitro evaluation of the floating tablets of Paliperidone with natural polymers. The Paliperidone tablets were prepared by physical direct compression method using guar gum and xanthan gum as natural polymers and Sodium bicarbonates. All the developed formulations were evaluated for physicochemical parameters, buoyancy, drug content, in vitro dissolution, Kinetic models and drug stability studies. The results were obtained within the limits for all formulations. Among all the formulations PF4 showed the better buoyancy and drug release profiles.

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Wojcik-Pastuszka, Dorota, Anna Lisik, Maria Twarda, Ryszard Berkowski, and Witold Musial. "The influence of hydrophylic polymers on the release rate of calcium dobesilate in hydrogel formulation assessed in vitro using porcine ear skin." Current Issues in Pharmacy and Medical Sciences 28, no. 4 (2015): 225–30. http://dx.doi.org/10.1515/cipms-2015-0076.

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Abstract A shortage of available experimental data exists in the available bibliography on the release rate of calcium dobesilate (CD) from hydrogel formulations. Thus, the aim of the study was to evaluate the effect of selected hydrophilic nonionic polymers and anionic polymers on the release rate of CD from formulation provided for dermal application, as compared to the reference product in the market. The work utilized excised pork skin, while, Methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), and anionic polymers (copolymers of acrylic acid) were used as CD carriers. The release

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Abbasnezhad, Navideh, Farid Bakir, Stéphane Champmartin, and Mohammadali Shirinbayan. "Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films." E3S Web of Conferences 321 (2021): 04011. http://dx.doi.org/10.1051/e3sconf/202132104011.

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Drug-eluting stents implanted in blood vessels are subject to various dynamics of blood flow. In this study, we present the evaluation of a mathematical model considering the effect of flow rate, to simulate the kinetic profiles of drug release (Diclofenac Sodium (DS)) from in-vitro from PLGA films. This model solves a set of non-linear equation for modeling simultaneously the burst, diffusion, swelling and erosion involved in the mechanisms of liberation. The release parameters depending on the flow rate are determined using the corresponding mathematical equations. For the evaluation of the

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Harada, S., S. Ehara, T. Segawa, et al. "Innovation of hyaluronic acid-protamine microparticles and their kinetics in vivo." International Journal of PIXE 26, no. 01n02 (2016): 45–51. http://dx.doi.org/10.1142/s0129083516500054.

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The nanoparticles, which releases anticancer drug with response to radiation, were developed. Also, two categories were tested: (i) their ability to release anticancer drug in vitro; and (ii) their kinetics in the body, when they were injected through tail vein of BALB/c mice in vivo. To prepare the particles, hyaluronic acid and protamine were mixed into carboplatin solution, and reacted for 30 min in room temperature. Those particles were exposed to a single dose of 10 Gy of 140 KeV X-ray. Their ability to release carboplatin with response to radiation was expressed as the percentage of rupt

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Khan, Kamran Ahmad, Gul Majid Khan, Muhammad Muzammal, et al. "Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents." Molecules 27, no. 3 (2022): 864. http://dx.doi.org/10.3390/molecules27030864.

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Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method

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Nur, Amran, Ermalyanti Fiskia, and Bambang Tjiroso. "Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP." E3S Web of Conferences 328 (2021): 01001. http://dx.doi.org/10.1051/e3sconf/202132801001.

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The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination o

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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GUPTA, SANJAY KUMAR, Sradhanjali Patra, and Syed Adnan Akber. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ALENDRONATE BUCCAL TABLETS." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 363–69. http://dx.doi.org/10.22270/jddt.v9i4-s.3253.

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The aim of this work was to develop a mucoadhesive buccal tablet for the buccal delivery of the alendronate via buccal mucosa. Buccal tablets of alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Alendronate sodium is a bisphosphonates which has antiresorptive effect which is implicated in the prophylaxis and treatment of osteoporosis. Sodium alginate, ethyl cellulose and carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailabili

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Miskan, Risha, S. M. Shahidulla, and Sana Sultana. "Revolutionizing Drug Delivery: Nicardipine Nanosuspension Formulation and In-Vitro Evaluation." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 137–47. http://dx.doi.org/10.22270/jddt.v13i12.6134.

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Nicardipine hydrochloride, is a potent calcium channel blocker, is commonly used in the management of hypertension and angina. It is a BCS class II drug which has low aqueous solubility and high permeability. In the present study, an attempt was made to formulate and evaluate nanosuspension of Nicardipine hydrochloride using different stabilizers, namely Tween 80, PVP K30, Poloxamer 188 by using Nanoprecipitation method with the objective to improve solubility and enhance dissolution of Nicardipine hydrochloride. Prepared nanosuspensions were evaluated for drug-excipient compatibility, particl

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Maram, Chinna Eswaraiah, and Jaya Sollu. "Formulation and In-Vitro Evaluation of Metformin Hydrochloride Sustained Release Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 24–29. http://dx.doi.org/10.22270/jddt.v9i4.3121.

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The objective of the present study was to study the effect of hydrophilic polymers on sustained release of metformin hydrochloride from tablets. Compatibility was studied by Fourier transform infrared spectroscopy. The tablets were prepared by direct compression technique using Xanthan gum alone and in combination with HPMC as release retardant. Di calcium phosphate was used as diluent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in-vitro dissolution. Pre and post compression parameters w

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Ruela, André Luís Morais, Eduardo Costa Figueiredo, Aline Gravinez Perissinato, Ana Carolina Zogbi Lima, Magali Benjamim Araújo, and Gislaine Ribeiro Pereira. "In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil." Brazilian Journal of Pharmaceutical Sciences 49, no. 3 (2013): 579–88. http://dx.doi.org/10.1590/s1984-82502013000300020.

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The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC). The VDC is an experimental apparatus employed in research, development, and the pharmaceutical field because it can simulate conditions closest to those established in clinical trials. Two transdermal nicotine delivery systems marketed in Brazil to release 14 mg over 24 hours were evaluated. Release studies were carried out using a regenerated cellulose dialysis membrane and permeation studies were carried out using

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Manalan, B. Valli, Nadendla Swathi, Narra Nandini, et al. "Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HCL." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 4 (2020): 138–45. http://dx.doi.org/10.33974/ijrpst.v1i4.206.

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The aim of the present study was to design an oral sustained release matrix tablet of highly water soluble biguanide anti diabetic drug. The matrix tablets are prepared by melt granulation method using HPMC K 200M as hydrophilic drug release retarding polymer, and stearic acid as melt able binder as well as hydrophobic carrier. The drug and excipients compatibility was studied by FT – IR. The formulated matrix tablets were characterized for physical parameters and in vitro dissolution profile. FT – IR spectra revealed the absence of drug excipients interaction. The physical parameters of the t

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