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Relevant bibliographies by topics / Indazole derivatives

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Academic literature on the topic 'Indazole derivatives'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Indazole derivatives"

1

Kousalya, Patil* Dr. Somashekhar M. Metri Divya Shirke. "Synthetic Strategy And Pharmacological Approaches Of Benzopyrazole: A Review." Int. J. in Pharm. Sci. 1, no. 7 (2023): 261–68. https://doi.org/10.5281/zenodo.8161568.

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Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. The presence of two nitrogen sites located in adjacent positions in the molecular structure allows indazole, at low concentrations in mildly acid or basic media, to form 1H and 2H tautomers via acid-base interactions as well as symmetrical dimers by hydrogen bonding. Indazole is also known as 1H-Benzopyrazole, 2-Azaindole. Synonyms of indazoles are 1H-Indazole, 2H-indazole, Isoindazole1,2-Diazaindene and Benzopyrazole. The first compound known to contain the indazole ring system was indazole and

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Saketi, Jagan Mohana Rao, S. N. Murthy Boddapati, Raghuram M., et al. "Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug." Applied Sciences 10, no. 11 (2020): 3792. http://dx.doi.org/10.3390/app10113792.

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A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives (5a–5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.

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S, Zine Babasaheb, Najan Sopan A, Dhonde Shrikant P, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.13319875.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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Babasaheb, S. Zine, A. Najan Sopan, and Farooqui Mazahar. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." DER PHARMA CHEMICA 15, no. 3 (2023): 4. https://doi.org/10.4172/0975-413X.15.3.34-37.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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S, Zine Babasaheb, Sopan A. Najan, Shrikant P. Dhonde, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.10952012.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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Alam, Ryan M., and John J. Keating. "Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution." Beilstein Journal of Organic Chemistry 17 (August 2, 2021): 1939–51. http://dx.doi.org/10.3762/bjoc.17.127.

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The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient synthesis and isolation of the desired N-1 or N-2 alkylindazole regioisomer can often be challenging and adversely affect product yield. Thus, as part of a broader study focusing on the synthesis of bioactive indazole derivatives, we aimed to develop a regioselective protocol for the synthesis of N-1 alkylindazoles. Initial screening of various con

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Wan, Yichao, Shengzhuo He, Wei Li, and Zilong Tang. "Indazole Derivatives: Promising Anti-tumor Agents." Anti-Cancer Agents in Medicinal Chemistry 18, no. 9 (2019): 1228–34. http://dx.doi.org/10.2174/1871520618666180510113822.

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Background: Currently, cancer continues being a dramatically increasing and serious threat to public health. Although many anti-tumor agents have been developed in recent years, the survival rate of patients is not satisfactory. The poor prognosis of cancer patients is closely related to the occurrence of drug resistance. Therefore, it is urgent to develop new anti-tumor agents to make up for the deficiency. Indazoles is an important class of heterocyclic compounds possessing a variety of biological activities, such as anti-tumor, anti-bacterial, antiinflammatory, anti-depressant and anti-hype

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Bhattacharjee, Suvam, Sudip Laru, and Alakananda Hajra. "Remote difunctionalization of 2H-indazoles using Koser's reagents." Chemical Communications 58, no. 7 (2022): 981–84. http://dx.doi.org/10.1039/d1cc06129a.

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Saketi, Jaganmohana Rao, S. N. Murthy Boddapati, Raghuram M, Geetha Bhavani Koduru, and Haribabu Bollikolla. "Novel Substituted Indazoles towards Potential Antimicrobial Agents." Oriental Journal Of Chemistry 37, no. 2 (2021): 508–12. http://dx.doi.org/10.13005/ojc/370234.

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The in vitroantimicrobial properties of a series of N-methyl-3-aryl indazoles (5a-5j) were screened. In this present work, we describe our efforts towards the development of potent antimicrobial activity of synthesized indazole derivatives. The antimicrobial activities of the prepared compounds were investigated against four bacterial strains: Xanthomonas campestris, Escherichia coli, Bacillus cereus, Bacillus megaterium, and a fungal strain Candida albicans. The biological evaluation studies of these indazole derivatives revealed that some of these tested compounds have shown moderate to good

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Hariyanti, Hariyanti, Arry Yanuar, Kusmardi Kusmardi, and Hayun Hayun. "(7E)-3-(4-Methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole." Molbank 2020, no. 4 (2020): M1162. http://dx.doi.org/10.3390/m1162.

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Indazole derivatives are well known to have various pharmacological activities. We synthesized a novel derivative of indazole, namely (7E)-3-(4-methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole by condensation reaction between 3-(4-methoxyphenyl)-3,3a,4,5,6,7-hexahydro-2H-indazole and 4-methoxy-benzaldehyde in good yield (61%).

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Dissertations / Theses on the topic "Indazole derivatives"

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Bland-Ward, Philip Antony. "Inhibition of nitric oxide synthase by indazole derivatives : an evaluation of the pharmacological effects of 7-nitro indazole in the cariovascular and central nervous systems." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363010.

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Chen, Jau-Yang, and 陳朝陽. "Synthesis of Indazole Derivatives as Nrf2 Regulators." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/6rhbrm.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>101<br>Nuclear factor (erythoid-derived 2)-like 2 (Nrf2) is a critical transcription factor regulating a cellular protective response that defends cells against toxic insults from a broad spectrum of chemicals. The activation of Nrf2 possesses chemopreventive activity against chemical carcinogenesis. A series of indazole derivatives was synthesized and bioevaluated for the Nrf2 activity on the nasopharyngeal carcinoma TW01-9ARE、TW01-15ARE、HSC3-9ARE. The results were shown that the introduction of Cl moiety into 4-position of indazole ring possessed the activation

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Chang, Chun Feng, and 張純鳳. "Design and Synthesis of Indazole-based Derivatives as Aurora Kinases Inhibitors." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/777teu.

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博士<br>國立清華大學<br>化學系<br>105<br>This dissertation is concerned with the development of indazole-based derivatives as Aurora kinases inhibitors. Based on the concept of ATP competitive inhibitors, indazole skeleton was selected as a starting point. Utilizing our in-house database by sub-structure screening, hit compound 47 was identified as the initial hit which showed weak inhibition against Aurora A. Compound 50a was further synthesized by using in silico FBDD techniques and resulting in 10-fold potency improvement. Following by rational drug design, the carboxylic acid group extended from anil

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Tsai, Ray-Ying, and 蔡睿盈. "Synthesis，Antiplatelet，Antiangiogenesis and Cytotoxicity Activity of 1-Benzyl-3-(5-substituted-2-furyl)-5-methoxy-1H-indazole Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/68278761980375752184.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Abstract 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) was first synthesized in our laboratory as a novel antiplatelet agent. Encouraged by the initial results, a series of 5-methoxy derivatives of YC-1 analogues were synthesized and examined for their biological activities. The starting material methyl 5-(3-methoxybenzoyl)-2-furoate (1) was treated with benzylhydrazine to yield a mixture of E- and Z-form isomers 2. The hydrazone was then treated with lead tetraacetate in dichloromethane at low temperature, then boron trifluoride e

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Chen, Hua-Sin, and 陳華鑫. "Synthesis and biological activities of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivative." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/47453222969722384672.

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博士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>In the previous study, ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was identified as the first selective non-peptide protease-activated receptor 4 (PAR4) antagonist. In order to develop noel PAR4 antagonist, YD-3 was selected as lead compound. Two series of N1-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (I) and N2-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (II) were synthesized. The key intermediate, ethyl 4-(1H-indazol-3-yl)- benzoate (8) was prepared according to the know method. Then, compound 8

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Book chapters on the topic "Indazole derivatives"

1

Kabi, Arup K., Raghuram Gujjarappa, Aakriti Garg, et al. "Highlights on Biological Activities of 1,3,4-Thiadiazole and Indazole Derivatives." In Tailored Functional Materials. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2572-6_7.

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2

Kikelj, D. "From Indazole Derivatives." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00861.

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3

Devkate, Chandrashekhar, Satish Kola, Mohammad Idrees, Naqui J. Siddiqui, and Roshan D. Nasare. "Eco-Friendly, Green Approach for Synthesis of Bio-Active Novel 3-Aminoindazole Derivatives." In Green Computing Technologies and Computing Industry in 2021. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95565.

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In present chapter we have reported green and highly efficient method for synthesize novel series of substituted -1H-indazol-3-amine derivative (3a-h) by cyclocondensation reaction of substituted benzonitrile (1a-h) and substituted Hydrazine (2a-h) using ceric (IV) ammonium nitrate (CAN) as a catalyst, EtOH-H2O as a ecofriendly media and reaction was carried out under ultrasound irradiation green method. The structures of newly synthesized indazole derivative (3a-h) were corroborated through spectral investigation such as elemental analysis and spectral studies like IR, C13 NMR, Mass spectra a

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4

Saketi, Jagan Mohana Rao, S. N. Murthy Boddapati, M. Raghuram, et al. "Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug." In New Ideas Concerning Science and Technology Vol. 11. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/nicst/v11/7323d.

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