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Journal articles on the topic 'Inflammatory Fibrous Hyperplasia'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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García Orellana, Brian Andrés, María de Lourdes León Vintimilla, and Martha Alejandra Cornejo Córdova. "Hiperplasia Fibrosa Inflamatoria: Reporte de un caso." Revista Médica del Hospital José Carrasco Arteaga 13, no. 1 (2021): 136–40. http://dx.doi.org/10.14410/2021.13.2.cc.22.

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BACKGROUND: Inflammatory fibrous hyperplasia associated with the use of removable dental prosthesis (IFH) is an adaptive lesion caused by long-term trauma exerted by a poorly adapted removable prosthesis on the oral mucosa, usually in the vestibular sulcus. Its diagnosis and treatment is imperative, due to its potential to cause discomfort to the patient, altering aesthetics, phonectics and chewing. CASE REPORTS: A 41-year-old denture wearer woman was referred due to discomfort in the right lower vestibular sulcus, the clinical examination showed a bilobed enlargement with an invagination where the edge of the prosthesis fits, the patient has worn the prosthesis for 15 years. EVOLUTION: Resection with scalpel (conventional technique) was performed. The histopathological examination reported inflammatory fibrous hyperplasia and a new total removable bimaxillary prosthesis was made for the patient. CONCLUSIONS: HFI is one of the main oral lesions in older adults denture wearers and it causes aesthetic and functional alterations; it is produced by the constant irritation caused by the settlement of the prosthesis borders on the mucovestibular sulcus as a consequence of alveolar resorption. Treatment is meant to eliminate the injury and its etiology; the absence of lesions on the mucosa and the bottom of the sulcus is completely necessary.

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Jaimes, Miguel, Jose Muñante, Jaime Giuseppe Rodrizuez-Chessa, et al. "Inflammatory Fibrous Hyperplasia Treated with a Modified Vestibuloplasty: A Case Report." Journal of Contemporary Dental Practice 9, no. 3 (2008): 135–41. http://dx.doi.org/10.5005/jcdp-9-3-135.

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Abstract Aim The purpose of this report is to present a case of surgical and prosthetic treatment of a woman with inflammatory fibrous hyperplasia (IFH) and her evaluation during a six month period. Background IFH is a benign pathology, prevalent in female patients, and principally associated with ill-fitting prosthetic devices in need of adjustment. It is common for patients to require surgical removal of the hyperplastic tissue and fabrication of a new prosthesis. Case Report A 55-year-old female with a history of smoking presented with a chief complaint of missing the scheduled adjustment of her maxillary complete denture and the presence of moveable tissue under the denture. Surgical excision of the hyperplastic tissue followed with fixation of the prosthesis for six months to guide the healing of the soft tissue and to reshape the contours of the maxillary supporting tissues. Summary Surgical removal of hyperplasic soft tissue is a routine procedure, and the fixation of the prosthesis for the support of tissue during healing improves intraoral conditions for the fabrication of a new prosthesis in the future. Citation Jaimes M, Muñante J, Rodriguez-Chessa JG, Olate S, de Albergaria-Barbosa JR, Mazzonetto R, Klüppel LE. Inflammatory Fibrous Hyperplasia Treated with a Modified Vestibuloplasty: A Case Report. J Contemp Dent Pract 2008 March; (9)3:135-141.

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Kaur, Jaspreet, Deepak Bala, Akshita Singh Thakur, Sarvani Chandel, and Viniti Goel. "Inflammatory fibrous hyperplasia – A case report." IP International Journal of Maxillofacial Imaging 9, no. 1 (2023): 35–38. http://dx.doi.org/10.18231/j.ijmi.2023.006.

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Gingival enlargement, the currently accepted terminology for an increase in the size of the gingiva, is a common feature of gingival disease. Local and systemic factors influence the gingival conditions of the patient. These factors results in a spectrum of diseases that can be developmental, reactive and inflammatory to neoplastic. In this case report, the history, etiology, clinical features, treatment strategies and preventive protocol of inflammatory hyperplasia are discussed.

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Mezaiko, Eleazar, Milena Moraes de Oliveira Lenza, Angela Natalia Garnica Hilarión, Reuber Mendes Rocha, Brunno Santos de Freitas Silva, and Fernanda Paula Yamamoto-Silva. "Oncocytic hyperplasia in inflammatory fibrous hyperplasia: a case report." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 139, no. 5 (2025): e48. https://doi.org/10.1016/j.oooo.2025.01.249.

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Jain, Mayuri. "True Fibroma on the Palate: A Unique Case." International Journal of Experimental Dental Science 5, no. 1 (2016): 69–71. http://dx.doi.org/10.5005/jp-journals-10029-1127.

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ABSTRACT Benign fibrous overgrowths are often found in the oral cavity. Majority of the fibromas occurring in the oral cavity are reactive in nature and represent inflammatory hyperplasia of fibrous connective tissue in response to local irritation or trauma rather than being a true neoplasm. True fibroma of the oral mucosa is an extremely rare benign neoplasm, only a few cases have been reported in the literature so far. Here, we report an exceptional case of relatively large true fibroma on the palate in an 80-yearold male patient, which was mimicking a hemangioma, not reported earlier in the literature. How to cite this article Jain M. True Fibroma on the Palate: A Unique Case. Int J Experiment Dent Sci 2016;5(1):69-71.

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Shanthi, M., Ganesh C, Hamsavardini, Donna T. Angela, Divya Deepika, and Divya VC. "Benign but troublesome: A case study of irritational fibroma in the oral cavity." Journal of Orofacial and Health Sciences 11, no. 4 (2024): 206–9. http://dx.doi.org/10.18231/j.johs.2024.040.

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In the oral cavity, fibroma is the most common type of connective tissue tumor. The size of these proliferative benign connective tissue tumors varies from tiny to large, contingent upon the degree of presence of one or more components of the inflammatory response. They are usually asymptomatic.It is a locally confined hyperplasia of fibrous connective tissue brought on by persistent inflammation or local trauma. This lesion is more typically observed in men, with a preference for buccal mucosa, labial mucosa, and tongue . This lesion preferentially affects the tongue, buccal mucosa, and labial mucosa. A traumatic or irritating fibroma develops from an inflammatory hyperplastic lesion that can occur at any age and in almost any soft tissue location.

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Faria, Michelly Luiza, Rafaela Flavia Barbosa, and Cizelene do Carmo Faleiros Veloso Guedes. "REABILITAÇÃO ORAL EM PACIENTE EDÊNTULA TOTAL COM HIPERPLASIA FIBROSA: relato de caso." Scientia Generalis 4, no. 2 (2023): 197–208. http://dx.doi.org/10.22289/sg.v4n2a15.

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Inflammatory fibrous hyperplasia or fissured epulis is a very common lesion in patients who use maladapted removable prostheses. It consists of a connective tissue overgrowth as a response to constant trauma in a specific area. Clinically, it is presented as an exophytic process or a well-defined elevation. It is generally, sessile-based and asymptomatic. Its consistency varies from firm to flaccid, with smooth surface or occasionally ulcerated, and its color is similar to the adjacent mucosa or erythematous. The most recommended treatment is surgical removal, however there are other methods such as cryotherapy, micro-abrasion and laser therapy. The aim of this work is to describe the stages of diagnosis and treatment, from the surgical technique for removing inflammatory fibrous hyperplasia to the patient's rehabilitation, with new prostheses. This is a case report of a 79-year-old female patient who attended the clinic at Faculdade Patos de Minas (FPM) reporting dissatisfaction with the loss of lip support and the aesthetics of her complete denture prosthetics. During the clinical examination, a nodular tissue growth was identified in the bottom region of the anterior maxillary vestibule’s sac. As a proposed treatment, an excisional biopsy was performed, confirming the diagnosis of inflammatory fibrous hyperplasia through histopathological analysis. After healing, new prostheses were produced, intending to meet the patient's requirements. The present study is expected to emphasize the importance of a thorough clinical examination, so that all changes in the patient are identified and, when necessary, perform a biopsy and histopathological analysis. In summary, it is essential to adjust or produce new prosthetic parts to prevent tissue trauma or cause negative consequences. The patient's postoperative period was uneventful, with favorable healing, and after the new prosthetic devices were put in place, function and aesthetics were restored.

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Nitin, Priyanka, Sreeshyla H S, and Usha Hegde. "Atypical Oral Fibrous Histiocytoma - An Uncommon Histiocytic Lesion Presenting as Inflammatory Fibrous Hyperplasia." Biomedical and Pharmacology Journal 15, no. 2 (2022): 897–900. http://dx.doi.org/10.13005/bpj/2424.

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Fibrous histiocytoma, as the name suggests, is a lesion which is prominently composed of a combination of fibroblastic & histiocytic cells. Fibrous histiocytoma can usually be seen as either cutaneous types or involving deep tissues. The diagnosis of fibrous histiocytoma is only confirmed after surgical excision. It is imperative to differentiate this lesion from the other aggressive forms of fibrohistiocytic neoplasms. Atypical Fibrous Histiocytoma (AFH) comes in the spectrum of fibrous histiocytic lesion ranging from benign to malignant lesions. Atypical Fibrous Histiocytoma in oral cavity is distinctly uncommon. This uncommon occurrence of the lesion needs to be made known of, to prevent inappropriate treatment. Hence, here we present an uncommon case report of Atypical oral fibrous histiocytoma which presented clinically as epulis fissuratum/ Inflammatory fibrous hyperplasia

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Dr., Bhargavi R., and Shilpa Shetty Dr. "Fibrous Hyperplasia – A Case Report." International Journal of Innovative Science and Research Technology 7, no. 7 (2022): 1681–84. https://doi.org/10.5281/zenodo.7024308.

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The benign and exophytic-looking irritation fibroma, also known as traumatic fibroma, is a frequent oral lesion. It can appear at any age and develops as a result of tissue damage. It is the final result of the inflammatory hyperplastic lesion after healing. The buccal mucosa, any soft tissue location, tongue, and gingiva are the most often affected sites. There is a preference for women. The preferred course of treatment for this reactive lesion is surgical excision. The purpose of this case report is to describe a benign lesion in a 54-yearold female patient who visited the department complaining of pain and swelling around the right upper front tooth for five months. Upon examination, the lesion was found to be well-circumscribed, smooth, firm, and reddish pink swelling measuring 0.5cmX0.5cm in the area of the right canine and premolar. Using a diode laser, the lesion was removed. One month after surgery, there was no sign of a recurrence. As it clinically mimics numerous illnesses including peripheral giant cell granuloma, pyogenic granuloma, or odontogenic tumours, histopathol

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Jayachandran, Mahesh, Shalini Kapoor, and Rethi Mahesh. "Idiopathic Gingival Fibromatosis Rehabilitation: A Case Report with Two-Year Followup." Case Reports in Dentistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/513153.

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Gingival enlargements are quite common and may be either inflammatory, noninflammatory, or a combination of both. Gingival hyperplasia is a bizarre condition causing esthetic, functional, psychological, and masticatory disturbances of the oral cavity. Causes of gingival enlargement can be due to plaque accumulation, due to poor oral hygiene, inadequate nutrition, or systemic hormonal stimulation (Bakaeen and Scully, 1998). It can occur as an isolated disease or as part of a syndrome or chromosomal abnormality. A progressive fibrous enlargement of the gingiva is a facet of idiopathic fibrous hyperplasia of the gingiva (Carranza and Hogan, 2002; Gorlin et al., 1976). It is described variously asfibromatosis gingivae, gingivostomatitis, hereditary gingival fibromatosis, idiopathic fibromatosis, familial elephantiasis,anddiffuse fibroma. We present a case of idiopathic gingival fibromatosis with its multidisciplinary approach of management.

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De Medeiros, Gláucia Helena Faraco, and Ricardo Mickielin Boscato. "Oral manifestations presented by patientes attended at stomatology clinic of the University of Southern Santa Catarina." Journal of Research in Dentistry 3, no. 6 (2016): 877. http://dx.doi.org/10.19177/jrd.v3e62015877-884.

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AIM: Determining the prevalence of oral minfestations in patients treated at the Stomatology Clinic of the University of Southern Santa Catarina (UNISUL). MATERIAL AND METHODS: It consisted of a retrospective study conducted in 2014, with 145 medical records of patients seen at the Stomatology clinic in the period of 2010 to 2014. Through a survey form prepared by the authors the normal variations, oral lesions, biopsies performed, histopathologic diagnoses and the correlation between clinical and histopathological diagnoses were registered. RESULTS: The data was then organized in a spreadsheet and descriptively analyzed by simple occurrence counting. Of the 145 records analyzed, 57 were from men and 88 were from women. Their age ranged between 12 and 76 years, with an average age of 47 years and eight months. Among the normal variations, the Fordyce granules were observed in 20.59% (34). The fibrous hyperplasia were the pathology most frequent, 23, 5% (20). The total number of biopsies was 35, and the correlation between the clinical and histological diagnoses was 65.71% (23), in particular for inflammatory fibrous hyperplasia and leukoplasia. CONCLUSIONS: The main variation of normality was the Fordyce beads while the inflammatory fibrous hyperplasia was the main pathology diagnosed.

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Schmidt, Mônica Jarema, André Tschoeke, Lúcia Noronha, et al. "Histochemical analysis of collagen fibers in giant cell fibroma and inflammatory fibrous hyperplasia." Acta Histochemica 118, no. 5 (2016): 451–55. http://dx.doi.org/10.1016/j.acthis.2016.04.007.

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Cruz, Gabriela Medeiros da, Samuel Trezena, Sabina Pena Borges Pêgo, Lívia Máris Ribeiro Paranaíba, Daniella Reis Barbosa Martelli, and Mario Rodrigues de Melo Filho. "Profile evaluation of patients diagnosed with non-neoplastic proliferative lesions in a dentistry clinic." Brazilian Journal of Oral Sciences 18 (April 8, 2019): e191350. http://dx.doi.org/10.20396/bjos.v18i0.8655140.

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Non-neoplastic proliferative lesions (NNPLs) are alterations that affect oral mucosal tissues. The etiology of these lesions is associated with local irritant processes, principally inflammation, infections and mechanical irritants. NNPLs are classified into four groups: inflammatory fibrous hyperplasia, pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell lesion. Aim: This cross-sectional, quantitative, retrospective, analytical, informative and educational study aimed to evaluate the profiles of patients who were diagnosed with any non-neoplastic proliferative lesion in the Unimontes Stomatology Clinic, Brazil. Methods: From January 2001 to June 2012, 1505 patients were counted who underwent anatomopathological examination, in addition to evaluations for other conditions. Results: Of these 1505 patients, 223 were diagnosed with some type of non-neoplastic proliferative lesion, and statistical analysis showed that 76% were female and 24% male and that 23.3% were between 41 and 50 years of age. Inflammatory fibrous hyperplasia was the most common NNPL (86.5%). Conclusion: Due to the high frequency of these lesions in the dental clinic, this type of survey has significant relevance for informing health professionals about these proliferative processes. This information is necessary, since the dentist is intimately involved in both the etiology, treatment and prevention of these lesions.

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Filgueiras, Andreza Maria De Oliveira, Helene Santos Carvalho Pereira, Ruth Tramontani Ramos, et al. "Prevalence of oral lesions caused by removable prosthetics." Revistas 73, no. 2 (2016): 130. http://dx.doi.org/10.18363/rbo.v73n2.p.130.

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The present study aimed to investigate the prevalence of injuries caused by removable prostheses in patients of clinical specialization in dentistry. Of 598 patients, 175 (29%) had some type of associated injury. The lesions found included erythematous candidiasis, inflammatory fibrous hyperplasia, inflammatory papillary hyperplasia, traumatic ulcer, angular cheilitis, irritative keratosis, and denture stomatitis. Inflammatory fibrous hyperplasia was the most prevalent lesion, found in 88 patients (50%), followed by erythematous candidiasis in 75 patients (43%). Of the total number of injured patients, 141 (81%) were women and 34 (19%) were men, and 101 patients (58%) were Caucasian and 37 (21%) were black. Most lesions were located in the upper alveolar ridge and the hard palate. The most widely used type of prosthesis was full upper prosthesis with 84 users (48%). The average usage time for all prostheses was 17 years (SD ± 13). Average patient age was 62 years (SD ± 14). The prevalence of injuries caused by removable prostheses is high, and prolonged use of the device and the presence of oral lesions are strongly associated. Moreover, women represent the largest number of users of the prostheses and therefore carry the majority of the injuries.

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Paulain Carvalho, Hannah Marcelle, Marcelo Vinicius De Oliveira, Gustavo Calvacanti Albuquerque, et al. "Fibrous Inflammatory Hyperplasia in an Atypical Location: a Case Report." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (2018): e80. http://dx.doi.org/10.1016/j.oooo.2018.02.232.

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de Oliveira, Henrique Climeck, André Tschoeke, Gabriele Claudino da Cruz, et al. "MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia." Pathology - Research and Practice 212, no. 12 (2016): 1108–12. http://dx.doi.org/10.1016/j.prp.2016.10.002.

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Chandan, Vishal S., Sejal S. Shah, Taofic Mounajjed, Michael S. Torbenson, and Tsung-Teh Wu. "Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma." Journal of Clinical Pathology 71, no. 6 (2017): 504–7. http://dx.doi.org/10.1136/jclinpath-2017-204820.

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AimsTo examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation.Methods28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored.ResultsCopper deposition was detected in 96% (27/28) of FNHs and 37% (7/19) of IHAs, P<0.001. In all cases, copper was seen within the hepatocytes only around the pseudo-portal tracts or areas of fibrosis. Copper deposition in IHA was significantly associated with presence of lymphocytic inflammation (P=0.04) but not associated with features like nodularity, fibrous bands, ductular proliferation, ballooned hepatocytes and steatosis (P>0.05, for all). In FNH, the presence and degree of copper deposition was not significantly associated with any histological features (P>0.05, for all).ConclusionsCopper deposition occurs more frequently in FNH (96%) than IHA (37%), P<0.001. However, the presence of copper alone cannot be used as a feature to differentiate between FNH and IHA.

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Montalván-Barzallo, Bryan Xavier, Juan Pablo Gomez-Morales, and Jacinto José Alvarado-Cordero. "Épulis Fissuratum Una Revisión de la Literatura." Killkana Salud y Bienestar 4, no. 1 (2020): 41–46. http://dx.doi.org/10.26871/killcana_salud.v4i1.507.

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Objetivo: Esta revisión de la literatura tiene como objetivo recopilar información y conclusiones de varios autores referente al diagnóstico, etiología, histología y tratamiento de épulis fissuratum. Antecedentes: El Épulis fissuratum también llamado hiperplasia paraprotetica o hiperplasia fibrosa reactiva, se define como una lesión hiperplásica fibrosa reactiva muy común en pacientes edéntulos portadores de prótesis removibles parciales y totales. La literatura disponible nos permite comparar varias opciones terapéuticas, pero muchas veces no engloba temas relacionados a diagnóstico clínico, histológico y la etiología de dicha lesión. Metodología: En esta revisión se realizó una búsqueda de literatura publicada en inglés o español hasta marzo de 2019 utilizando MEDLINE, PUBMED & COCHRANE, las palabras clave fueron (Treatment of Paraprotetic Hyperplasia, Management and diagnosis of Epulis Fissuratum & Therapeutics applied to Inflammatory Fibrous Hyperplasia). Los artículos fueron elegidos si contenian artículos publicados o aceptados para publicación hasta marzo de 2019, Revisiones de literatura, reporte de un caso, reporte de casos, estudios controlados aleatorizados y estudios clínicos comparativos.

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Rithanya P, Archana Santhanam, and Subhashree R. "Clinical Spectrum of Angiomatous Granuloma and Inflammatory Fibrous Hyperplasia- A Retrospective Study." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 159–62. http://dx.doi.org/10.26452/ijrps.v11ispl3.2907.

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Angiomatous granuloma is a reactive tumour-like lesion commonly seen in the oral cavity. It generally occurs due to proliferation of capillary blood vessels. Whereas, inflammatory fibrous hyperplasia (IFH) refers to gingival enlargement, which is the current terminology for an increase in the size of the gingiva and is a common feature of gingival diseases. Therefore, the aim of the current study is to analyse the clinical spectrum of angiomatous granuloma/ IFH in a private dental hospital. This study was carried out in a hospital setting (single centred study). The data of the study subjects was collected after a complete analysis of data of 86000 patients between June 2019 and March 2020. The data of the patients, including age, gender clinical diagnosis and histopathological reports, were collected and analysed using the Chi-square test to find the association between the clinical and histopathological reports in the study. In the present study, angiomatous granuloma(55%) had a higher prevalence compared to IFH (40%) with higher gender predilection among the female population (61.5%) and generally in the age group ranging from 20 to 40 years. (57.5%) [p value= 0.329] statistically not significant. Similarly, IFH was also found to be higher in the female population of about (38.4%), in the age groups between 20 to 50 years (41.3%). The knowledge of various clinical presentations and histopathological characteristics the lesion is necessary for proper identification and treatment planning.

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CHAGAS, ALINE AMANCIO, LIONEY NOBRE CABRAL, and TIAGO NOVAES PINHEIRO. "GIANT CELL FIBROMA, INFLAMMATORY FIBROUS HYPERPLASIA AND PSEUDOMEMBRANOUS CANDIDIASIS IN THE SAME PATIENT: A CASE REPORT." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 2 (2017): e116. http://dx.doi.org/10.1016/j.oooo.2017.05.289.

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DE MACEDO, LUCIANO NOBRE. "INFLAMMATORY FIBROUS HYPERPLASIA: PREVALENCE OF DIAGONOSED CASES IN A UNIVERSITY AND CASE REPORTS." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (2020): e37. http://dx.doi.org/10.1016/j.oooo.2019.06.109.

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Halim, Daddy Suradi, Abdullah Pohchi, and Pang EE Yi. "The Prevalence of Fibroma in Oral Mucosa Among Patient Attending USM Dental Clinic Year 2006-2010." Indonesian Journal of Dental Research 1, no. 1 (2010): 61. http://dx.doi.org/10.22146/theindjdentres.9991.

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The purpose of this preliminary retrospective study was to determine the prevalence of fibroma in oral mucosa among patients attending USM dental clinic from 1/6/2006-1/6/2010. Fibroma of the oral mucosa is the most common benign tumor of the oral cavity. It is a reactive hyperplasia of fibrous connective tissue in response to local irritation or trauma. A lesion on any part of the oral mucosa have a broad differential diagnosisranging from traumatic lesions (mucocele), neurogenic lesions (neurofibromatosis), lipoma , epithelial tumors (squamous papilloma) and inflammatory/reactive hyperplasia of soft tissue (pulp polyp). A total number of 192 patients (82 male and 110 female) who are registered in the Oral Medicine and Oral Pathology Log Book were included in this study regardless of their age, 16 % of them were diagnosed to have fibroma and out of that, 29% of them were male and 79% female. The peak incidence of the lesion was in the 3rd decade of life. The lesions occurred in the tongue, lip mucosa, sulcus region and buccal mucosa were each to be 12.9%, 12.9% , 32.2 % and 41.9%. This study shows that fibroma is one of the common oral mucosal lesion and it occurred mostly in the 3rd decade of life where the prevalence is higher in female patients.

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Tomazelli, Karin Berria, Filipe Modolo, and Elena Riet Correa Rivero. "Evaluation of AgNORs in Oral Potentially Malignant Lesions." Journal of Oncology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/218280.

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Oral squamous cell carcinoma (OSCC) is usually preceded by detectable mucosal changes, as leukoplakias and erythroplakia. Histologically, these lesions can range from hyperkeratosis and acanthosis to epithelial dysplasia and even OSCC. The aim of this study was to investigate the proliferative activity, using AgNORs quantification proteins, in low- and high-risk oral epithelial dysplasia, OSCC, and nondysplastic epithelium (inflammatory fibrous hyperplasia). The sample was divided into 4 groups: G1: 10 cases of inflammatory fibrous hyperplasia (IFH), G2: 11 cases of low-risk epithelial dysplasia (LD), G3: 10 cases of high-risk epithelial dysplasia (HD), and G4: 11 cases of OSCC. The quantitative analysis was performed using an image processing software in photomicrographs at 1000x magnification. The one-way ANOVA was used for comparison of the mean AgNORs counts between the study groups. The mean AgNORs count was significantly higherP≤0.01in OSCC when compared to IFH and the LD; however, it was not statistically different from HD. The mean number of LD was significantly lower than the HD and OSCC, with no difference related to IFH. AgNORs quantification can be an important and cheap method to help in the determination of the degree of epithelial dysplasia and, consequently, in the analysis of their potential for malignant transformation.

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Şahin, Sevinç, Sema Avcı, and Aytekin Esra Çobankent. "The investigation of appendiceal size and volume in pediatric appendectomy specimens in terms of histopathological diagnosis, seasonal variability, age, and gender." Chronicles of Precision Medical Researchers 4, no. 2 (2023): 119–25. https://doi.org/10.5281/zenodo.8063721.

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Aim: Acute appendicitis is a common condition mostly in children with unclear etiology that is treated with an emergency appendectomy. However, some unexpected diagnoses called as “negative appendectomy” that do not require treatment may be detected histopathologically. In this study, it was aimed to investigate the histopathologic diagnoses of pediatric appendectomy specimens, considering the macroscopic dimensions and volume of the specimens for the first time in the literature and comparing them with age and gender groups, and seasons of the operations to achieve additional data in preventing negative appendectomy. Material and Method: A total of 122 cases were included in this study. The length, longest diameter, and shortest diameter, as well as the volume of each specimen, were measured during the macroscopic examination. The specimens were evaluated for histopathologic diagnosis according to age, gender, and the season in which the operation was performed. Results: The male-to-female ratio was 1.2. Histopathologically, there were 81 (74.6%) inflammatory [mainly acute appendicitis (65.5%)], and 31 (25.4%) non-inflammatory diseases [mainly lymphoid hyperplasia (21.3%)] that were considered negative appendectomy. Inflammatory diseases were operated mostly in winter (p=0.0099), while non-inflammatory diseases were operated mainly in autumn (p=0.0099). The length, longest diameter (y), and appendiceal volume were significantly greater in inflammatory than in non-inflammatory ones (p=0.0006, p=0.0126, and p=0.0016, respectively). Length and volume were more significant in acute appendicitis than in lymphoid hyperplasia (p=0.0124 and p=0.0358, respectively). In patients ≤12 years, lymphoid hyperplasia was more common in females than in males (p<0.001). In patients >12 years, acute appendicitis was more common in females than males (p<0.034). Conclusion: In this study, histopathological diagnoses observed in appendectomy specimens were evaluated for the first time in the literature according to macroscopic appendix size and volume, as well as age, gender, and seasonal variations. The obtained data have the potential to provide additional information to the literature regarding epidemiological, appropriate preoperative, and pathological approaches

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de Andrade Santos, Pedro Paulo, Cassiano Francisco Weege Nonaka, Leão Pereira Pinto, and Lélia Batista de Souza. "Immunohistochemical expression of mast cell tryptase in giant cell fibroma and inflammatory fibrous hyperplasia of the oral mucosa." Archives of Oral Biology 56, no. 3 (2011): 231–37. http://dx.doi.org/10.1016/j.archoralbio.2010.09.020.

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da Silva, Giselle Diniz Guimarães, and Tiago Novaes Pinheiro. "Histomorphometric comparative analysis between the oral mucosa of fibrous inflammatory hyperplasia and oral leukoplakia." Translational Cancer Research 9, no. 4 (2020): 3101–6. http://dx.doi.org/10.21037/tcr.2019.12.23.

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De Jesus, Alessandro Oliveira, Michelle Danielle Porto Matias, Isadora Pereira Gomes, Christine Dos Santos Bernis, Leandro Napier De Souza, and Ricardo Alves Mesquita. "Split-Mouth Clinical Trial with Diode LASER and Electrocautery Treatment for Inflammatory Fibrous Hyperplasia." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (2018): e156. http://dx.doi.org/10.1016/j.oooo.2018.02.623.

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DA SILVA, GISELLE DINIZ GUIMARÃES, and TIAGO NOVAES PINHEIRO. "HISTOMORPHOMETRIC COMPARISON ANALYSIS BETWEEN NORMAL BUCCAL MUCOSA OF FIBROUS INFLAMMATORY HYPERPLASIA AND ORAL LEUKOPLAKIA." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 2 (2017): e136. http://dx.doi.org/10.1016/j.oooo.2017.05.375.

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Cruz, B. L., A. O. de Jesus, M. D. P. Matias, et al. "Diode laser versus electrocautery for inflammatory fibrous hyperplasia treatment: a split-mouth clinical trial." International Journal of Oral and Maxillofacial Surgery 48 (May 2019): 228–29. http://dx.doi.org/10.1016/j.ijom.2019.03.703.

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da-Silva-Barros, Caio César, Maurília Raquel de Souto Medeiros, Delane Maria Rêgo, Márcia Cristina da Costa Miguel, and Éricka Janine Dantas da-Silveira. "Inflammatory Fibrous Hyperplasia Associated with Chondroid Metaplasia - Report and Morphological Analysis of Five Cases." International journal of odontostomatology 17, no. 1 (2023): 101–6. http://dx.doi.org/10.4067/s0718-381x2023000100101.

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Canger, Emin Murat, Peruze Celenk, and Saadettin Kayipmaz. "Denture-related hyperplasia: a clinical study of a turkish population group." Brazilian Dental Journal 20, no. 3 (2009): 243–48. http://dx.doi.org/10.1590/s0103-64402009000300013.

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Inflammatory fibrous hyperplasia (epulis fissuratum) (IFH) and inflammatory papillary hyperplasia (IPH) are oral mucosal diseases caused by ill-fitting denture wearing. A study was carried out on a group of Turkish people consisted of 131 female and 39 male complete denture wearers (n= 170) distributed in two age groups (30-60 and 60-80 years old). The analysis of data collected from patients showed that while the incidence of IFH was higher in women than in men, the incidence of IPH was similar. Most lesions were found in the 30-60 year-old group. The incidence of lesions increased as the denture wearing period increased. Soft tissue growth was the main complaint of the patients with IFH and IPH. In the maxilla, the incidence of IFH was higher than IPH. There was also a significant difference between the distribution of the lesion types in the jaws. There were a larger number of lesions in the maxilla compared to the mandible and most IFH lesions were located in the anterior region of the jaws.

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Andriola, Fernando De Oliveira, Leonardo Matos Santolim Zanettini, Ricardo Giacomini De Marco, Camila Kunz, Cássia Dos Santos Machado Vaz, and Rogério Miranda Pagnoncelli. "Diode laser in the surgical treatment of inflammatory fibrous hyperplasia: Case report and literature review." Revista Odonto Ciência 32, no. 3 (2018): 154. http://dx.doi.org/10.15448/1980-6523.2017.3.28054.

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OBJECTIVE: This article presents a case of inflammatory fibrous hyperplasia (IFH) treated by diode laser surgery, as well as a review of the literature about this pathology.CASE DESCRIPTION: A 55-year-old woman was referred to the Department of Oral and Maxillofacial Surgery, Pontifical Catholic University of Rio Grande do Sul, School of Dentistry, complaining of a discomfort on swallowing due to a soft-tissue mass in the oral cavity that had been developing for approximately 3 years. Intraoral examination revealed multiple exophytic, pedunculated lesions with a smooth surface and pinkish in color, affecting almost the entire right cheek mucosa. The lesion turned out to be a IFH by histopatology. Surgical removal of IFH of the oral mucosa using a diode laser was performed. The lesion was removed in 3 sessions. The patient reported no local symptoms after each irradiation. The clinical appearance 10 months after the last irradiation session demonstrated complete healing and no signals of recurrence.CONCLUSION: Based on the results obtained, we can conclude that diode laser radiation contributes significantly to the advancement of oral surgery and should be considered a valuable resource for the treatment of soft-tissue lesions in the field of oral and maxillofacial surgery.

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Orlei, Rodrigues Ramos, Teixeira Júnior Jozias, Lima de Moraes Isa, and Jacon Jacob Rodrigo. "EXCISÃO DE HIPERPLASIA FIBROSA INFLAMATÓRIA POR PRÓTESE MAL ADAPTADA - RELATO DE CASO." Revistaft 28, no. 134 (2024): 48. https://doi.org/10.5281/zenodo.11182348.

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A Hiperplasia Fibrosa Inflamatória (HFI) desponta no tecido conjuntivo fibroso e embora sejam análogas as neoplasias, todavia, são lesões benignas que surgem após a irritação crônica relacionada ao uso de próteses dentárias mal adaptadas. Estas lesões são consideradas reativas e proliferativas, as quais crescem às bordas das dentaduras, contudo possuem um prognóstico bom e o tratamento é cirúrgico atrelado concomitantemente à substituição das próteses antigas com as novas e consequentemente bem adaptadas. Ademais, o presente trabalho busca descrever um caso clínico de excisão de HFI em paciente com prótese mal adaptada analisando sinais, sintomas e tratamento odontológico. Nesse sentido, para atingir tal objetivo o método para elaboração foi o caso clínico e revisão bibliográfica realizada em artigos científicos publicados nos últimos anos, sem restrições de idiomas, e indexados nos seguintes sites de pesquisa: PUBMED, Scientific Electronic Library (SciELO) e Google Acadêmico utilizando como palavras-chave: “Hiperplasia Fibrosa Inflamatória”, “prótese mal adaptada” e “tratamento”. Conclusão, o tratamento cirúrgico extraindo completamente a lesão, bem como a remoção de agentes irritantes, através de próteses adaptadas, tem por intento o bem-estar e também estabelecer qualidade de vida aos pacientes edêntulos.

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Mailoa, Elizabeth, Peter Rovani, and Edy Machmud. "Penanganan edentulus total rahang atas yang dengan disertai denture-induced hyperplasia Management of total maxillary edentulous with denture-induced hyperplasia." Journal of Dentomaxillofacial Science 11, no. 1 (2012): 28. http://dx.doi.org/10.15562/jdmfs.v11i1.290.

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Lesions caused by traumatic or unbalance occlusion, and overextension denture may occur in the majority ofpatients who use denture. This generally occurs in the use of unfit full dentures (FD) and in a long period of timecausing chronic irritation to mucosal tissues caused by the sharp and overextension of the FD flange. One of themost common tissue reaction caused by using unfit FD is inflammatory fibrous hyperplasia or more commonlyknown as the flabby ridge. This tissue reaction appears as fold of mucosal tissue, single or multiple, growexcessively around the sulcus mucobuccal, on the mucosa area unite gingiva and the cheek mucosa. Movement andgrowth of the tissue continuously causes problems in maintaining retention of FD. This article reports themanagement of denture-induced hyperplasia on maxilla edentulous of a 65-year old woman. Hyperplasia occurredfrom the left premolar to right premolar region of the maxilla. Excision was carried out through a 7 cm length tissueand then made for a conventional FD. As the result, patients are satisfied with the use of the new FD and did notfeel any further disruption to mucosal tissues

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Gorban, N. Ye, T. D. Zadorozhna, I. B. Vovk, and I. V. Zhulkevych. "MORPHOLOGICAL FEATURES OF UTERINE POLYPS IN FEMALES OF REPRODUCTIVE AGE." Вісник наукових досліджень, no. 2 (July 3, 2019): 47–52. http://dx.doi.org/10.11603/2415-8798.2019.2.10267.

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According to modern views based on evidence-based medicine, the concept of "poly-endometrium" is defined as a benign, exophytic nodophilic formation of the uterine mucus that consists of glands and stroma, predominantly fibrous, containing a "tangle" of thick-walled blood vessels. The aim of the study – to learn the morphological features of tissues of polyps of the body of the uterus and endometrium with the establishment of the role of inflammatory factor in the pathogenesis of hyperproliferative changes in women of reproductive age. Materials and Methods. The article presents the results of a survey of 62 patients of reproductive age with polyps in the body of the uterus. The presence of the glandular component in 79.03 % of cases, fibrotic polyps – 12.9 %, and micro-polyps – 8.06 % were determined, respectively. The combination of polyps with non-atypical endometrial hyperplasia was detected in 80 % of patients with micro-polyposis, in 63.6 % of women – with glandular-cystic polyps of the uterine body, in 44.4 % of the examined – with glandular-fibrous endometrial polyps and in 37.5 % of patients – with fibrous polyps. Immunohistochemically, CD138 expression was detected both in the tissues of the polyps of the uterus and adjacent endometrial tissues in 43.5 % of cases, which became a marker of the chronic endometritis in the part of the surveyed, which formed the basis of the pathogenetic approaches in the treatment of such a pathology. For processing data standard procedures using Microsoft Excel were used. The research was conducted in the Laboratory of Pathomorphology of the Department of O. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine, head of the department – Corresponding Member of the National Academy of Medical Sciences of Ukraine, Professor T. Zadorozhna. Results and Discussion. In clinical analysis of complaints of polyps of the body of the uterus, clinical manifestations in the form of menstrual cord disturbance were 13 (20.97 %) patients, in 11 (17.74 %) patients there were no complaints about the desired pregnancy, at the same time as 38 (61.29 %) women were asked to carry out a preventive examination, which does not contradict the results of other researchers. During the morphological study, we established the following features of the polyps of the body of the uterus in women of reproductive age: the most frequently tested polyps of the body of the uterus, which had the glandular component – in 49 (79.03 %) cases, of which the glandular-cystic structure was found in 22 (35.48 %) of patients, the glandular-fibrous structure was in 27 (43.55 %) patients, approximately the same values were found in fibrous polyps of the body of the uterus – 8 (12.90 %) of women and micropolymers of endometrium – in 5 (8.06 %) cases respectively. We found that in all groups of patients with polyps in the body of the uterus, there were signs of non-atypical hyperplasia of the endometrium. It should be noted that, according to literature, endometrial polyps larger than 15 mm were associated with hyperplasia. The above data is an important indication that the unidirectional determination of the positive expression of the CD138 inflammatory marker, both in the tissue of the polyp of the uterus and in the endometrial tissue, indicates the unity of the inflammatory factor in the pathogenesis of hyperproliferative processes and proves the significant role of the inflammatory process in the development of its pathological conditions and justifies the necessity take into account this fact in approaches to the tactics of patient management. Conclusions. The results of the conducted morphological and immunohistochemical research indicate that the basis of the formation of polyps of the body of the uterus is the inflammatory process, which is confirmed morphologically with the presence of chronic endometritis and a positive reaction to CD138. The study of pathogenetic mechanisms for the formation of endometrial pathology is a key factor in the development of methods for correction of these pathological processes, which thus allows to increase the efficiency of treatment and preserve reproductive health.

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Ali Khan, Amjad, Abdul Shaheed Asghar, Muhammad Ishaq, and Israr Ahmed Akhund. "APPENDICULAR DISEASES;." Professional Medical Journal 24, no. 08 (2017): 1114–19. http://dx.doi.org/10.29309/tpmj/2017.24.08.960.

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Acute appendicitis is a common cause of acute surgical abdomen and manyappendectomies are performed daily. All disease processes involving appendix will present asacute appendicitis. Clinically diagnosed acute appendicitis is treated by urgent appendectomy.As most of the removed appendices will reveal acute suppurative inflammation, therefore,appendectomy specimens are not usually submitted for histopathological examination unlessthe surgeon notices advanced disease or grossly recognizable abnormalities. Objectives: Thepurpose of this study is; 1, to explore the spectrum of diseases affecting the appendix in thecommunity; 2, to find the age and gender association of appendicular diseases; and 3, to seeif all the surgically removed appendices should be submitted for histopathological examinationas a routine procedure. Study Design: Retrospective study. Setting: Charsada TeachingHospital affiliated with Jinnah Medical College Peshawar. Period: January 2013 to January2016. Methods: The histology slides and diagnoses of all the retrieved cases were reviewedwith regards to morphology, patient’s age, gender and presence or absence of any associateddisease. Results: Nine disease entities were identified affecting the appendix, which from mostto least common were acute suppurative appendicitis, lymphoid hyperplasia, fecalith, fibrousluminal obliteration, oxyuriasis, carcinoid tumor, submucosal fibrosis, acquired diverticulosis,and inflammatory mucocele. The first three commonest diseases were most frequent in thesecond decade of life; fibrous luminal obliteration in the fourth decade, carcinoid tumors inthe third decade, and oxyuriasis in the first decade. Moreover, acute suppurative appendicitis,fecalith, oxyuriasis, and submucosal fibrosis were more frequent in males; whereas, lymphoidhyperplasia and fibrous luminal obliteration were more common in females. Conclusions:Acute suppurative appendicitis was the most common histological diagnosis. Acute suppurativeappendicitis, fecalith, oxyuriasis, and submucosal fibrosis were more common in males;whereas, lymphoid hyperplasia and fibrous luminal atresia were more common in females.Acute suppurative appendicitis, lymphoid hyperplasia, and fecalith were most common in thesecond decade of life. In view of the nine different histological disease entities identified in thisstudy under one clinical diagnosis of acute appendicitis, it is highly recommended to submit allappendectomy specimens for histopathological examination.

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Matveeva, N. Yu, D. G. Pavlush, and S. G. Kalinichenko. "Morphogenesis and molecular regulation of polyposis rhinosinusitis." Russian Journal of Archive of Pathology 87, no. 1 (2025): 68. https://doi.org/10.17116/patol20258701168.

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Polyposis rhinosinusitis (CRSwNP) is a heterogeneous proliferative disease characterized by inflammatory hyperplasia of the nasal mucosa with dysregulation of apoptosis and cell differentiation. The review summarizes data on the molecular cellular mechanisms of CRSwNP and presents the concept of intercellular signaling during polyposis growth. Various factors that form a specific endotype are involved in the development of a polyp. Features of morphogenesis make it possible to distinguish edematous, eosinophilic and fibrous NP. In all cases, markers of neurogenic inflammation, impaired expression of proinflammatory cytokines, NO synthase, BMP-2 and other morphogenetic molecules arerecorded. The growing polyp and the inflammatory reaction damage the epithelium of the mucous membrane and bone wall of the nasal cavity. Interleukin-1β and BMP-2 are an integrative link in the pathogenesis of these events.

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Murry, Jean N., Mongshithung N. Murry, Anshul Gangwar, and Mhao P. Jungio. "Establishing Aesthetics by Purposeful Autoreimplantation in Inflammatory Fibrous Hyperplasia: A 12-Month Follow-up Case Report." International Journal of Clinical Pediatric Dentistry 17, no. 2 (2024): 216–20. http://dx.doi.org/10.5005/jp-journals-10005-2783.

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van Esch, E., H. C. Dreef-van der Meulen, and V. J. Feron. "Spontaneous hyperplastic and metaplastic duct epithelium in the sublingual salivary glands of Wistar rats." Laboratory Animals 20, no. 2 (1986): 127–31. http://dx.doi.org/10.1258/002367786780865052.

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Focal epithelial hyperplasia and metaplasia were observed in the intralobular ducts of the sublingual salivary glands of 302 out of 1142 Wistar rats. These rats (aged 16-145 weeks) served as controls in toxicological experiments. The ductal changes varied from small groups of irregular cylindrical cells with basophilic cytoplasm and vesicular nuclei, with often prominent nucleoli, to large areas of non-keratinized stratified squamous epithelium with marked mitotic activity and necrotic superficial cells being released in the lumen. Mononuclear inflammatory cells were often present in fibrous tissue surrounding altered ducts. Within certain limits the degree and incidence of the changes increased with increasing age; their aetiology is unknown.

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AGOP-FORNA, Doriana, Claudiu TOPOLICEANU, and Norina FORNA. "Laser Applications in Oral Surgery." Annals of the Academy of Romanian Scientists Series on Biological Sciences 10, no. 2 (2021): 48–55. http://dx.doi.org/10.56082/annalsarscibio.2021.2.48.

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Oral surgery can be assisted by surgical lasers: diode, erbium, CO2, Nd:YAG. The surgical lasers are used in various procedures on oral soft and bone tissues: aesthetic procedures (gingival recontouring, gingival depigmentation); operculectomy; pro-prosthetic surgical procedures (remodeling of mucosa on edentulous sites, dental crown lengthening, frenectomies, vestibuloplasty); excision of gingival or mucosa hyperplasia; peri-implantitis treatment; the removal of small exophytic lesions; the removal of oral benign lesions (ranula, mucocele, pyogenic granuloma, fibrous hyperplasia, epulis fissuratum, hemangioma). For optimum effects at the level of the target oral tissues, the laser energy parameters should be set in relation to the wavelength, the type of intervention, the nature of the inflammatory process (acutechronic), the tissue penetration depth, tissue pigmentation, and systemic status. The oral surgical procedures performed by surgical lasers are recommended in modern dentistry due to lower risk of soft and hard tissues necrosis, decreased rate of complications, higher patients’ compliance (decreased postoperative pain and discomfort) and the acceleration of the healing processes.

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Gera, Divya, Anshul Tanwar, Anant G. Nigam, Shradha Jain, and Vipul Sharma. "Pyogenic granuloma in a 6-year-old boy - a rare case report." International Journal of Contemporary Pediatrics 10, no. 4 (2023): 607–10. http://dx.doi.org/10.18203/2349-3291.ijcp20230749.

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The gingiva, also known as the gums, is the pink-coloured keratinized mucosa that surrounds and protects the teeth. Gingival enlargement or gingival overgrowth, a common trait of gingival disease, is characterized by an increase in the size of gingiva. Irritation fibroma is an exophytic soft tissue mass in the oral mucosa. Indeed, it is not a real neoplasm, but a focal hyperplasia of fibrous connective tissue induced by local trauma or chronic irritation. Pyogenic granuloma is one of the inflammatory hyperplasia seen in the oral cavity, majority are found on the marginal gingiva with only 15% of the tumours on the alveolar part. It predominantly occurs in the second decade of life in young females, male to female ratio is 1:99, and size of lesion varies in diameter from few millimetres to several centimetres. This article presents a case of pyogenic granuloma in an 6year old boy who presented with a gingival overgrowth in his mandibular left buccal surface region i.r.t 31 including marginal and attached gingiva. He had discomfort during mastication, interferes with occlusion there was episode of bleeding during brushing. The lesion was excised and histopathological report confirmed the diagnosis. Case was followed up for six months and no recurrence of the lesion. Etiological factors, clinical features, differential diagnosis and different treatment options are discussed based on the review of current literature available.

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Shet, RGK, Shobith R. Shetty, M. Kalavathi, M. Naveen Kumar, Rishi Dev Yadav, and S. Soumya. "A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients." Journal of Contemporary Dental Practice 14, no. 5 (2013): 904–10. http://dx.doi.org/10.5005/jp-journals-10024-1424.

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ABSTRACT Geriatric dentistry or gerodontics is the delivery of dental care to older adults involving the diagnosis, prevention and treatment of problems associated with normal aging and age-related diseases as part of an interdisciplinary team with other health care professionals. Aim To evaluate the oral mucosal status in the elderly population of different age group and find out the association of age, gender and denture with oral mucosal disorders. Materials and methods The study sample consisted of 570 geriatric persons concentrating mainly on the oral mucosal changes or lesions occurring in the geriatric population. Individuals those are aged above 60 years were selected, and all the examined geriatric persons were categorized into 3 age groups to find out the association of oral mucosal lesions in each group. Group I—60 to 65 years, Group II—66 to 70 years, Group III—71 and above years. Results The sample of 570 elderly patients included 279 (48.95%) men and 291 (51.05%) women in three age groups: 61 to 65 years (40.35%), 66 to 70 years (31.05%), and 71 years and older (28.60%). The sample included 254 (44.56%) dentate patients, 205 (35.96%) denture wearers (partial and complete denture wearers) and 111 (19.47%) edentulous persons who lacked dentures in both the jaws. Almost half of the patients examined (48%) had one or more oral mucosal lesions. The 48% of the patients who presented with oral mucosal lesions, twenty five different oral mucosal conditions were identified and the three most common findings were lingual varices (13.68%), denture induced inflammatory fibrous hyperplasia (4.21%), squamous cell carcinoma (4.21%). There was some differences in the distribution of oral mucosal condition among the sexes. Leukoplakia and dysplasia were significantly associated with men (p < 0.001) whereas the association of fibroma and lichen planus with women were significant (p < 0.001). Conclusion In our study it was found that patients in groups II and III had more prevalence of oral mucosal disorders. Lingual varices, oral squamous cell carcinoma, fibroma and denture induced inflammatory fibrous hyperplasia were more commonly associated with the geriatric patients. The oral lesions (fibroma and lichen planus) were strongly associated with women while leukoplakia was strongly associated with men. Ageing is an important factor that can influence the occurrence of mucosal lesions and with age the oral mucosa becomes more permeable to noxious substances and more vulnerable to external carcinogens. How to cite this article Shet RGK, Shetty SR, M Kalavathi, Kumar MN, Yadav RD, S Soumya. A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients. J Contemp Dent Pract 2013;14(5):904-910.

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K. Al-Malaak, Maha. "Histopathological changes on Splenomegaly induced in Experimental rats Wistar albino." AL-QADISIYAH MEDICAL JOURNAL 10, no. 18 (2017): 50–62. http://dx.doi.org/10.28922/qmj.2014.10.18.50-62.

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This study was aimed to evaluate histopathological changes in experimental rats with induced splenomegaly and liver fibrosis by administering thioacetamid (TAA). Liver fibrosis was clearly noticed in all experimental rats after intraperitoneally injected with a dose (200mg/kg) body weight for 8 weeks ,while control rats injected with buffered saline.The body , spleen and liver weight were recorded , also ratio of liver and spleen per body weight was estimated.Macroscopical changes including (colour, size, congested, signs of fibrosis, irregularity, nature of surface) regarded to liver and spleen were clarified. The livers showed coarse granulation surface, fibrous (white) spots, pale color and congested with large size, while spleen appeared enlarged, reddish, with fibrous regions, twister and fragil easy to destruct.Biochemical results revealed to statistical difference (p<0.05) in the rate of albumin and total protein concentration in splenomegaly rats compared to control. Inhibition of both (Gpt and Got) enzymes was estimated in rats with splenomegaly up compared to control rats.There was statistical difference in the mean concentration of total bilirubin in splenomegaly rats in comparison to control rats. The results of microscopic investigation of tissue sections related to rats liver with enlarged spleen showed dilation in portal veins with an increased in (PV) diameter in relation to control rats, also significant increased with splenic lymph nodules diameter in splenomegaly rats compared to control rats.Results on liver sections stained with (PAS) reagent indicated to dense, coarse and red glycogen granules were deposit on hepatocytes also fibrosis, hyperplasia, fibrous septa, large amount of collagen fibers and destruction of normal lobules were observed.The results referred to swollen hepatocytes, pyknotic nuclei, vacuoles with lipid accumulation and moderate steatosis was obvious in all sections of livers with cirrhosis .Hyperplasia, dilated bile ducts and infiltration of inflammatory cells. Spleen sections of splenomegaly rats showed congested red pulp, some lymph nodule s appeared active and more than one aggregated together, thickening in fibrous trabecullae and numerous macrophages with hemosidrin deposite.Hemorrhage with large numbers of erythrocytes and platelets deposit in large blood vessels, thickening in capsule with more fibrous tissue compared with control rats.

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Zhang, Hao, and Weimin He. "Two cases of IgG4-related ophthalmic disease (IgG4-ROD) involving only the sclera." Indian Journal of Ophthalmology - Case Reports 5, no. 2 (2025): 258–61. https://doi.org/10.4103/ijo.ijo_2373_24.

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We report two cases of IgG4-related ophthalmic disease (IgG4-ROD) that exclusively involve the sclera. Both patients presented with eye redness of varying severity, photophobia, tearing, and other associated symptoms. Pathological examination of the surgically removed tissues revealed fibrous hyperplasia, marked inflammatory infiltration, increased IgG4-positive cells, and elevated serum IgG4 levels—findings consistent with the diagnostic criteria for IgG4-ROD. After surgery, a systemic examination confirmed that the eye lesions were confined to the sclera and did not involve other common sites. Both of them were regularly reviewed in the ophthalmology department and received standardized postoperative care in the rheumatology and immunology department after surgery. The prognosis was good, and no recurrence or further progression was observed during follow-up.

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Tizro, Parastou, Taraneh Hashemi Zonouz, Fawaz Almutairi, and Donald Karcher. "A Rare Case of Kimura Disease in the Wrist." Blood 134, Supplement_1 (2019): 4881. http://dx.doi.org/10.1182/blood-2019-125984.

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Kimura disease is a rare benign chronic inflammatory disorder of unknown etiology that typically involves lymph nodes and soft tissues. This disease is most common in middle-aged Asian men. Although the disorder most frequently involves the head and neck region, it has also been reported to involve the extremities. Lesions typically show follicular lymphocytic hyperplasia with prominent interfollicular venules and a mixed inflammatory infiltrate, including numerous eosinophils. We describe a case of Kimura disease in a 29-year-old female presenting with a slowly enlarging, painless soft tissue mass in her left wrist for five months. The lesion was non-tender, mobile, and compressible. Lab results were significant for peripheral blood eosinophilia and elevated IgE. Microscopically, the mass was circumscribed, with apparent fibrous capsule or pseudocapsule, prominent high-endothelial venules, and inflammatory cells consisting of lymphocytes and eosinophils. There were prominent secondary B-lymphocytic follicles with germinal centers containing many penetrating small blood vessels, and some follicles exhibiting follicle lysis and a small amount of eosinophilic extracellular material. Polykaryocytes were noted in many germinal centers. Angiolymphoid hyperplasia with eosinophilia, a main differential diagnosis of Kimura disease, was considered; however, the combined clinical and morphologic findings appeared to be more consistent with Kimura disease, particularly in the context of eosinophilia and elevated IgE level. Kimura disease may present as a rare cause of a soft tissue mass and a diagnostic challenge for clinicians and pathologists, especially in less common sites such as the wrist. Disclosures No relevant conflicts of interest to declare.

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Kocaelli, H., and N. Keklikoglu. "Inducible Nitric Oxide Synthase Immunoreactivity in Denture Induced Fibrous Inflammatory Hyperplasia and Healthy Oral Mucosa: An Immunohistochemical Study." Biotechnology & Biotechnological Equipment 23, no. 3 (2009): 1378–82. http://dx.doi.org/10.1080/13102818.2009.10817674.

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de Jesus, Alessandro Oliveira, Michelle Danielle Porto Matias, José Alcides Almeida de Arruda, et al. "Diode laser surgery versus electrocautery in the treatment of inflammatory fibrous hyperplasia: a randomized double-blind clinical trial." Clinical Oral Investigations 24, no. 12 (2020): 4325–34. http://dx.doi.org/10.1007/s00784-020-03296-3.

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Pereira, Isadora Lima, Fabio Augusto Ito, Ademar Takahama Júnior, et al. "Health Promotion and Diagnosis of Oral Diseases in Institutionalized Elderly People: An Experience Report." International Journal of Environmental Research and Public Health 22, no. 7 (2025): 1097. https://doi.org/10.3390/ijerph22071097.

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This study presents the findings of an academic extension project focused on promoting oral health and diagnosing oral lesions in institutionalized elderly individuals. The project involved visits by students and faculty to two nursing homes in southern Brazil. Data collection included extraoral and intraoral clinical examinations and educational activities such as lectures and the distribution of printed materials on oral and denture hygiene. According to caregiving staff, oral hygiene, including denture cleaning, was generally performed once daily during morning showers. A total of 118 older adults (68 males and 50 females; mean age 76.1 ± 8.6 years) were examined. Forty-nine used dentures, of whom only 24 (49%) reported satisfaction with their prostheses. In total, 42 oral lesions were identified, mainly angular cheilitis (8), inflammatory fibrous hyperplasia (7), irritation fibroma (7), frictional hyperkeratosis (7), prosthetic stomatitis (5), actinic cheilitis (3), traumatic ulcers (3), and leukoplakia (2). Educational sessions also targeted caregivers, offering practical guidance for improving hygiene practices. The results underscore the need for better oral care and improved access to dental services for institutionalized elderly populations. Academic extension activities play a valuable role in health promotion and in training future professionals in elderly care.

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Çayan, Timuçin, Güzin Neda Hasanoğlu Erbaşar, Gülçin Akca, and Sevil Kahraman. "Comparative Evaluation of Diode Laser and Scalpel Surgery in the Treatment of Inflammatory Fibrous Hyperplasia: A Split-Mouth Study." Photobiomodulation, Photomedicine, and Laser Surgery 37, no. 2 (2019): 91–98. http://dx.doi.org/10.1089/photob.2018.4522.

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Makuszewska, Maria, Robert Bartoszewicz, and Kazimierz Niemczyk. "Pathogenesis of middle ear acquired cholesteatoma in the light of the research using high-throughput, “omics”, technologies of molecular biology." Polski Przegląd Otorynolaryngologiczny 8, no. 3 (2019): 1–5. http://dx.doi.org/10.5604/01.3001.0013.4885.

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Cholesteatoma is described as cystic lesion consisting of keratinizing squamous cell epithelium, filed with keratin debris, surrounded by inflammatory fibrous tissue, gradually expanding in the middle ear and causing destruction of neighboring bones. This paper presents brief review of existing hypotheses explaining its etiology in the light of the researches using high-throughput, “omics”, technologies of molecular biology. Classic theories of pathogenesis of acquired cholesteatoma as: immigration, squamous metaplasia, basal cell hyperplasia or invagination theory have not been able to explain fully all pathological processes observed in cholesteatoma tissue. This also concerns the newer concepts that cholesteatoma is a result of mucosal traction generated by interaction of migrating opposing surfaces, a natural attempt by the body to cure the underlying inflammation in the cavity or chronic wound healing process triggered by micro defects in the basement membrane of the epithelium in the retraction pocket. Introduction of high-throughput, “omics”, technologies of molecular biology to the studies under cholesteatoma pathogenesis allowed identification of cholesteatoma-related gene expression signatures using full-genome microarrays as well as proteomic analysis of cholesteatoma. This studies confirmed known pathological processes observed in cholesteatoma tissue such as: high proliferative activity, decreased signal transduction, active immunological response, alterations in the extracellular matrix, increased expression of proinflammatory cytokines, neovascularization and may others. This techniques allow precise and complete view of molecular mechanisms in those processes. However it is still unknown what is the cause that trigger epithelial hyperplasia, inhibited migration and inflammatory response in the preexisting retraction pocket.

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