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Journal articles on the topic 'Integrin-assisted imaging and theranostics'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kossatz, Susanne, Ambros Johannes Beer та Johannes Notni. "It’s Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals". Cancers 13, № 23 (2021): 5958. http://dx.doi.org/10.3390/cancers13235958.

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For almost the entire period of the last two decades, translational research in the area of integrin-targeting radiopharmaceuticals was strongly focused on the subtype αvβ3, owing to its expression on endothelial cells and its well-established role as a biomarker for, and promoter of, angiogenesis. Despite a large number of translated tracers and clinical studies, a clinical value of αvβ3-integrin imaging could not be defined yet. The focus of research has, thus, been moving slowly but steadily towards other integrin subtypes which are involved in a large variety of tumorigenic pathways. Pepti

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Fan, Linxin, Doudou Huang, Yichuan Wang, et al. "Cryo-assisted exfoliation of atomically thin 2D Sb2Se3 nanosheets for photo-induced theranostics." Chemical Communications 55, no. 19 (2019): 2805–8. http://dx.doi.org/10.1039/c9cc00576e.

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Sha, Shuang, Fei Yang, Anle Wang, Honglin Jin, Zhihong Zhang, and Qiaoya Lin. "Fluorescent and quantitative mitochondrial redox imaging of tumor targeted by Octa-RGD probe." Journal of Innovative Optical Health Sciences 09, no. 04 (2016): 1642002. http://dx.doi.org/10.1142/s1793545816420025.

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Integrins, over-expressed in a broad range of cancer diseases, are widely utilized as a tumor biomarker. Metabolism investigation also plays important roles in tumor theranostics. Developing simple integrin-targetting probe and monitoring tumor metabolism will give opportunities to find ways for cancer treatment, however, the investigation of tumor metabolism with integrin receptor based probes has been rarely reported so far. Here, we developed an octavalent fluorescent probe Octa-RGD by convenient genetic method, based on one tetrameric far-red fluorescent protein (fRFP) linked with RGD pept

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Lin, Bi, Yanxing Wang, Kun Zhao, et al. "Exosome-based rare earth nanoparticles for targeted in situ and metastatic tumor imaging with chemo-assisted immunotherapy." Biomaterials Science 10, no. 3 (2022): 744–52. http://dx.doi.org/10.1039/d1bm01809d.

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In this research, a tumor exosome system DOX/2DG@E-RENPs with good biocompatibility, low immunogenicity, and a high targeting effect was proposed for theranostics with high chemo-/starvation/immunotherapy efficiency.

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Gauthé, Mathieu, Paul Sargos, Eric Barret, et al. "Potential Targets Other Than PSMA for Prostate Cancer Theranostics: A Systematic Review." Journal of Clinical Medicine 10, no. 21 (2021): 4909. http://dx.doi.org/10.3390/jcm10214909.

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Background: Prostate-specific membrane antigen (PSMA) is not sufficiently overexpressed in a small proportion of prostate cancer (PCa) patients, who require other strategies for imaging and/or treatment. We reviewed potential targets other than PSMA for PCa theranostics in nuclear medicine that have already been tested in humans. Methods: We performed a systematic web search in the PubMed and Cochrane databases, with no time restrictions by pooling terms (“prostate cancer”, “prostatic neoplasms”) and (“radioligand”, “radiotracer”). Included articles were clinical studies. The results were synt

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Li, Yang, Jichuan Kong, Huan Zhao, and Yao Liu. "Synthesis of Multi-Stimuli Responsive Fe3O4 Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy." Molecules 28, no. 4 (2023): 1784. http://dx.doi.org/10.3390/molecules28041784.

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Nanodiamonds with magnetic resonance imaging (MRI) and targeted drug delivery to exert combined effects for biomedical applications have been considered to be an urgent challenge. Herein, a novel bio-nanoarchitectonics (Fe3O4@NDs) with simultaneous imaging and therapeutic capacities was fabricated by covalently conjugating nanodiamonds (NDs) with Fe3O4. Fe3O4@NDs exhibited better biocompatibility and excellent photothermal stability with superb photothermal conversion performance (37.2%). Fe3O4@NDs has high doxorubicin (DOX) loading capacity (193 mg/g) with pH and NIR-responsive release charac

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Huang, Jianpan, Zilin Chen, Se-Weon Park, Joseph H. C. Lai, and Kannie W. Y. Chan. "Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges." Pharmaceutics 14, no. 2 (2022): 451. http://dx.doi.org/10.3390/pharmaceutics14020451.

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Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) detects molecules in their natural forms in a sensitive and non-invasive manner. This makes it a robust approach to assess brain tumors and related molecular alterations using endogenous molecules, such as proteins/peptides, and drugs approved for clinical use. In this review, we will discuss the promises of CEST MRI in the identification of tumors, tumor grading, detecting molecular alterations related to isocitrate dehydrogenase (IDH) and O-6-methylguanine-DNA methyltransferase (MGMT), assessment of treatment effec

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Wang, Lin, Syu-Ming Lai, Cun-Zhao Li, Hsiu-Ping Yu, Parthiban Venkatesan, and Ping-Shan Lai. "D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments." Pharmaceutics 14, no. 5 (2022): 1000. http://dx.doi.org/10.3390/pharmaceutics14051000.

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Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study, water-soluble amphiphilic vitamin E (TPGS, d-alpha-tocopheryl poly(ethylene glycol 1000) succinate) formulated MZF nanoparticles were synthesized to serve as both a magnetic resonance imaging (MRI) contrast agent and a vehicle for creating magnetically induced hyperthermia against cancer. The MZF nanoparticles were synthesized from a metallic acetylacetonate in an

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Christou, Evangelia, John R. Pearson, Ana M. Beltrán, et al. "Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy." Pharmaceutics 14, no. 3 (2022): 636. http://dx.doi.org/10.3390/pharmaceutics14030636.

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The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flowe

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Perdigon-Lagunes, Pedro, Octavio Estevez, Cristina Zorrilla Cangas, and Raul Herrera-Becerra. "Gd – Gd2O3 multimodal nanoparticles as labeling agents." MRS Advances 3, no. 14 (2018): 761–66. http://dx.doi.org/10.1557/adv.2018.244.

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ABSTRACTLanthanide nanoparticles had the possibility to couple many imaging techniques into a sole labeling agent has awaken high expectations on personalized medicine or <<Theranostics>>. This is possible due to their intrinsic physic – chemical properties. Combining different imaging techniques physicians may provide a better treatment and perform surgical procedures that might increase the survival rate of patients. Hence, there is an enormous opportunity area for the development of lanthanide multimodal nanoparticles. For this study, we synthesized Gd – Gd2O3 nanoparticles at r

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Jiang, Xiaokun, Shamma Khan, Adam Dykes, Eugen Stulz, and Xunli Zhang. "Biogenic Synthesis of Silver Nanoparticles and Their Diverse Biomedical Applications." Molecules 30, no. 15 (2025): 3104. https://doi.org/10.3390/molecules30153104.

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Nanoparticles (NPs) synthesised through biogenic routes have emerged as a sustainable and innovative platform for biomedical applications such as antibacterial, anticancer, antiviral, anti-inflammatory, drug delivery, wound healing, and imaging diagnostics. Among these, silver nanoparticles (AgNPs) have attracted significant attention due to their unique physicochemical properties and therapeutic potential. This review examines the biogenic synthesis of AgNPs, focusing on microbial, plant-based, and biomolecule-assisted approaches. It highlights how reaction conditions, such as pH, temperature

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Thakur, Mukeshchand, Sunil Pandey, Ashmi Mewada, et al. "Antibiotic Conjugated Fluorescent Carbon Dots as a Theranostic Agent for Controlled Drug Release, Bioimaging, and Enhanced Antimicrobial Activity." Journal of Drug Delivery 2014 (March 18, 2014): 1–9. http://dx.doi.org/10.1155/2014/282193.

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A novel report on microwave assisted synthesis of bright carbon dots (C-dots) using gum arabic (GA) and its use as molecular vehicle to ferry ciprofloxacin hydrochloride, a broad spectrum antibiotic, is reported in the present work. Density gradient centrifugation (DGC) was used to separate different types of C-dots. After careful analysis of the fractions obtained after centrifugation, ciprofloxacin was attached to synthesize ciprofloxacin conjugated with C-dots (Cipro@C-dots conjugate). Release of ciprofloxacin was found to be extremely regulated under physiological conditions. Cipro@C-dots

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Vakili, Sanaz, Iman Beheshti, Amir Barzegar Behrooz, Marek J. Łos, Rui Vitorino, and Saeid Ghavami. "Transforming Prostate Cancer Care: Innovations in Diagnosis, Treatment, and Future Directions." International Journal of Molecular Sciences 26, no. 11 (2025): 5386. https://doi.org/10.3390/ijms26115386.

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Prostate cancer remains a major global health challenge, ranking as the second most common malignancy in men worldwide. Advances in diagnostic and therapeutic strategies have transformed its management, enhancing patient outcomes and quality of life. This review highlights recent breakthroughs in imaging, including multiparametric MRI and PSMA-PET, which have improved cancer detection and staging. Biomarker-based diagnostics, such as PHI and 4K Score, offer precise risk stratification, reducing unnecessary biopsies. Innovations in treatment, including robotic-assisted surgery, novel hormone th

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Liu, Renna, Fanli Xu, Lu Wang, et al. "Polydopamine-Coated Laponite Nanoplatforms for Photoacoustic Imaging-Guided Chemo-Phototherapy of Breast Cancer." Nanomaterials 11, no. 2 (2021): 394. http://dx.doi.org/10.3390/nano11020394.

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Theranostic nanoplatforms combining photosensitizers and anticancer drugs have aroused wide interest due to the real-time photoacoustic (PA) imaging capability and improved therapeutic efficacy by the synergistic effect of chemotherapy and phototherapy. In this study, polydopamine (PDA) coated laponite (LAP) nanoplatforms were synthesized to efficiently load indocyanine green (ICG) and doxorubicin (DOX), and modified with polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) for PA imaging-guided chemo-phototherapy of cancer cells overexpressing αvβ3 integrin. The formed ICG/LAP-PDA-PEG

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Dai, Wenhao, Haifeng Dong, and Xueji Zhang. "A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency." Materials 11, no. 9 (2018): 1776. http://dx.doi.org/10.3390/ma11091776.

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Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo2C QDs) with a diameter of approximately 6 nm and a topographic height of about 1.5 nm were synthesized using a facile sonication-assisted liquid-phase exfoliation appr

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Pretze, Marc, Valeska von Kiedrowski, Roswitha Runge та ін. "αvβ3-Specific Gold Nanoparticles for Fluorescence Imaging of Tumor Angiogenesis". Nanomaterials 11, № 1 (2021): 138. http://dx.doi.org/10.3390/nano11010138.

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This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αvβ3-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were evaluated in an optical imaging setting in vitro and in vivo exhibiting favorable diagnostic properties with regards

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Pretze, Marc, Valeska von Kiedrowski, Roswitha Runge та ін. "αvβ3-Specific Gold Nanoparticles for Fluorescence Imaging of Tumor Angiogenesis". Nanomaterials 11, № 1 (2021): 138. http://dx.doi.org/10.3390/nano11010138.

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This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αvβ3-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were evaluated in an optical imaging setting in vitro and in vivo exhibiting favorable diagnostic properties with regards

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18

Basirinia, Ghazal, Muhammad Ali, Albert Comelli, et al. "Theranostic Approaches for Gastric Cancer: An Overview of In Vitro and In Vivo Investigations." Cancers 16, no. 19 (2024): 3323. http://dx.doi.org/10.3390/cancers16193323.

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Gastric cancer (GC) is the second most common cause of cancer-related death worldwide and a serious public health concern. This high death rate is mostly caused by late-stage diagnoses, which lead to poor treatment outcomes. Radiation immunotherapy and targeted therapies are becoming increasingly popular in GC treatment, in addition to surgery and systemic chemotherapy. In this review, we have focused on both in vitro and in vivo research, which presents a summary of recent developments in targeted therapies for gastric cancer. We explore targeted therapy approaches, including integrin recepto

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Mulens-Arias, Vladimir, Alba Nicolás-Boluda, Alexandre Gehanno, Alice Balfourier, Florent Carn, and Florence Gazeau. "Polyethyleneimine-assisted one-pot synthesis of quasi-fractal plasmonic gold nanocomposites as a photothermal theranostic agent." Nanoscale 11, no. 7 (2019): 3344–59. http://dx.doi.org/10.1039/c8nr09849b.

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Pirooznia, Nazanin, Khosrou Abdi, Davood Beiki та ін. "Radiosynthesis, Biological Evaluation, and Preclinical Study of a 68Ga-Labeled Cyclic RGD Peptide as an Early Diagnostic Agent for Overexpressed αvβ3 Integrin Receptors in Non-Small-Cell Lung Cancer". Contrast Media & Molecular Imaging 2020 (31 березня 2020): 1–11. http://dx.doi.org/10.1155/2020/8421657.

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The αvβ3 integrin receptors have high expression on proliferating growing tumor cells of different origins including non-small-cell lung cancer. RGD-containing peptides target the extracellular domain of integrin receptors. This specific targeting makes these short sequences a suitable nominee for theranostic application. DOTA-E(cRGDfK)2 was radiolabeled with 68Ga efficiently. The in vivo and in vitro stability was examined in different buffer systems. Metabolic stability was assessed in mice urine. In vitro specific binding, cellular uptake, and internalization were determined. The tumor-targ

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Ataei, Marzieh, Hsiu-Ping Yi, Aida Zahra Taravatfard, Ken Young Lin, and Abraham Phillip Lee. "Enhancing Structural Stability of Oil-Shell Microbubbles via Incorporation of a Gold Nanoparticle Protective Shell for Theranostic Applications." Colloids and Interfaces 7, no. 2 (2023): 34. http://dx.doi.org/10.3390/colloids7020034.

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Phospholipid-stabilized microbubbles are utilized as contrast agents in medical ultrasound imaging, and researchers are currently investigating their potential as theranostic agents. Due to the inadequate water solubility and poor stability of numerous new therapeutics, the development of stable microbubbles with the capacity to encapsulate hydrophobic therapeutics is necessary. Herein, we proposed a flow-focusing microfluidic device to generate highly monodispersed, phospholipid-stabilized dual-layer microbubbles for theranostic applications. The stability and microstructural evolution of the

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Lo, Wei-Lin, Shih-Wei Lo, Su-Jung Chen, et al. "Molecular Imaging and Preclinical Studies of Radiolabeled Long-Term RGD Peptides in U-87 MG Tumor-Bearing Mice." International Journal of Molecular Sciences 22, no. 11 (2021): 5459. http://dx.doi.org/10.3390/ijms22115459.

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The Arg–Gly–Asp (RGD) peptide shows a high affinity for αvβ3 integrin, which is overexpressed in new tumor blood vessels and many types of tumor cells. The radiolabeled RGD peptide has been studied for cancer imaging and radionuclide therapy. We have developed a long-term tumor-targeting peptide DOTA-EB-cRGDfK, which combines a DOTA chelator, a truncated Evans blue dye (EB), a modified linker, and cRGDfK peptide. The aim of this study was to evaluate the potential of indium-111(111In) radiolabeled DOTA-EB-cRGDfK in αvβ3 integrin-expressing tumors. The human glioblastoma cell line U-87 MG was u

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Jin, Zhao-Hui, Atsushi B. Tsuji, Mélissa Degardin, Pascal Dumy, Didier Boturyn, and Tatsuya Higashi. "Multiplexed Imaging Reveals the Spatial Relationship of the Extracellular Acidity-Targeting pHLIP with Necrosis, Hypoxia, and the Integrin-Targeting cRGD Peptide." Cells 11, no. 21 (2022): 3499. http://dx.doi.org/10.3390/cells11213499.

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pH (low) insertion peptides (pHLIPs) have been developed for cancer imaging and therapy targeting the acidic extracellular microenvironment. However, the characteristics of intratumoral distribution (ITD) of pHLIPs are not yet fully understood. This study aimed to reveal the details of the ITD of pHLIPs and their spatial relationship with other tumor features of concern. The fluorescent dye-labeled pHLIPs were intravenously administered to subcutaneous xenograft mouse models of U87MG and IGR-OV1 expressing αVβ3 integrins (using large necrotic tumors). The αVβ3 integrin-targeting Cy5.5-RAFT-c(-

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Song, Fan-Xin, Xiaojian Xu, Hengze Ding, et al. "Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer." Biosensors 13, no. 1 (2023): 106. http://dx.doi.org/10.3390/bios13010106.

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Bladder cancer (BCa) is one of the most expensive and common malignancies in the urinary system due to its high progression and recurrence rate. Although there are various methods, including cystoscopy, biopsy, and cytology, that have become the standard diagnosis methods for BCa, their intrinsic invasive and inaccurate properties need to be overcome. The novel urine cancer biomarkers are assisted by nanomaterials-based biosensors, such as field-effect transistors (FETs) with high sensitivity and specificity, which may provide solutions to these problems. In addition, nanomaterials can be appl

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Zhu, Lijun, Ting Yan, Gulinigaer Alimu, et al. "Liposome-Loaded Targeted Theranostic Fluorescent Nano-Probes for Diagnosis and Treatment of Cervix Carcinoma." Journal of Biomedical Nanotechnology 18, no. 5 (2022): 1289–301. http://dx.doi.org/10.1166/jbn.2022.3332.

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Near-infrared fluorescence imaging, with its high sensitivity, non-invasiveness, and superior real-time feedback properties, has become a powerful skill for accurate diagnosis in the clinic. Nanoparticle-assisted chemotherapy is an effective cure for cancer. Specifically, the combination of near-infrared fluorescence imaging with chemotherapy represents a promising method for precise diagnosis and treatment of cervical cancer. To realize this approach, it is necessary to design and synthesize therapeutic nano-probes with detection abilities. In this work, an organic NIRF emissive heptamethine

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Irmania, Novi, Khalilalrahman Dehvari, and Jia-Yaw Chang. "Multifunctional MnCuInSe/ZnS quantum dots for bioimaging and photodynamic therapy." Journal of Biomaterials Applications 36, no. 9 (2022): 1617–28. http://dx.doi.org/10.1177/08853282211068959.

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In this work, manganese (Mn)-doped CuInSe quantum dots (QDs) with a ZnS passivation layer (MnCuInSe/ZnS) have been synthesized via a one-pot microwave-assisted hydrothermal reaction using glutathione (GSH) as a stabilizer. The MnCuInSe/ZnS core-shell QDs combine magnetic resonance imaging (MRI), excitation-dependent red emission, and reactive oxygen radical generation functions, in which regulation of Mn2+ incorporation leads to synergistic imaging and therapeutic modalities. The MnCuInSe/ZnS QDs exhibit high colloidal and photochemical stability in simulated media and at different pH values.

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Onega, Mayca, Christine A. Parker, Christopher Coello та ін. "Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung". European Journal of Nuclear Medicine and Molecular Imaging 47, № 4 (2020): 958–66. http://dx.doi.org/10.1007/s00259-019-04653-5.

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Abstract Purpose Integrin αvβ6 belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of cancer and pulmonary fibrosis. This paper describes the GMP radiolabelling of the synthetic 20 amino acid peptide A20FMDV2 (NAVPNLRGDLQVLAQKVART), derived from the foot-and-mouth disease virus, and characterises the use of [18F]FB-A20FMDV2 as a high affinity, specific and selective PET radioligand for the quantitation and visualisation of αvβ6 in rodent lung to support human translational studies. Methods The synthesis of [18F]FB-A2

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Littrup, Peter J., Mohammad Mehrmohammadi, and Nebojsa Duric. "Breast Tomographic Ultrasound: The Spectrum from Current Dense Breast Cancer Screenings to Future Theranostic Treatments." Tomography 10, no. 4 (2024): 554–73. http://dx.doi.org/10.3390/tomography10040044.

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This review provides unique insights to the scientific scope and clinical visions of the inventors and pioneers of the SoftVue breast tomographic ultrasound (BTUS). Their >20-year collaboration produced extensive basic research and technology developments, culminating in SoftVue, which recently received the Food and Drug Administration’s approval as an adjunct to breast cancer screening in women with dense breasts. SoftVue’s multi-center trial confirmed the diagnostic goals of the tissue characterization and localization of quantitative acoustic tissue differences in 2D and 3D coronal image

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Carrese, Barbara, Chiara Cavallini, Paolo Armanetti, et al. "Hybrid Nanoparticle-Assisted Chemo-Photothermal Therapy and Photoacoustic Imaging in a Three-Dimensional Breast Cancer Cell Model." International Journal of Molecular Sciences 24, no. 24 (2023): 17374. http://dx.doi.org/10.3390/ijms242417374.

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Bioinspired nanoparticles have recently been gaining attention as promising multifunctional nanoplatforms for therapeutic applications in cancer, including breast cancer. Here, the efficiency of the chemo-photothermal and photoacoustic properties of hybrid albumin-modified nanoparticles (HSA-NPs) loaded with doxorubicin was evaluated in a three-dimensional breast cancer cell model. The HSA-NPs showed a higher uptake and deeper penetration into breast cancer spheroids than healthy breast cell 3D cultures. Confocal microscopy revealed that, in tumour spheroids incubated with doxorubicin-loaded N

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Theodoropoulos, Athanasios S., Ioannis Gkiozos, Georgios Kontopyrgias, et al. "Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review." SAGE Open Medicine 8 (January 2020): 205031212096159. http://dx.doi.org/10.1177/2050312120961594.

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Introduction: In this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography. Methods: We conducted review of the current literature at PubMed/MEDLINE until February 2020. The search language was English. Results: The most widely used radiopharmaceuticals are the following: Experimental/pre-clinical approaches: (18)F-Misonidazole (18F-MISO) under clinical development, D(18)F-Fluoro-Methyl-Tyrosine (18F-FMT), 18F-FAMT (L-[3-18F] (18)F-Fluorothymidine (18F-FLT)), (18)F-Fluoro-Azomycin-

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Rakesh, Sharma. "Breast Cancer: Innovations, Clinical Course, Nanomedicine, Relapse and Optimal Management of Breast Cancer Using Sodium MRI-PET Imaging, Artificial Intelligence and Virtual Reality Methods." Recent Trends in Information Technology and its Application 8, no. 1 (2025): 44–93. https://doi.org/10.5281/zenodo.14666799.

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<em>Advanced breast cancer poses a life threat. It represents lumps, mammary cell carcinoma, mammary gland nodules and metastasis with direct clinical course. Such metastases may pose resistance to chemo/immunotherapy with only option left of careful theranostic multiparametric tumor monitoring, tumor killing and surgery. The paper focuses on n</em><em>ano-radiotracer assisted sodium MRI-PET apoptosis evaluation, accumulated intracellular sodium based breast tumor classification, use of nanomedicine in theranosis of human breast tumor, deep learning by reduced noise and minimal artifacts with

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Okada, Tomoko, та Toshihiko Ogura. "Nanoscale imaging of the adhesion core including integrin β1 on intact living cells using scanning electron-assisted dielectric-impedance microscopy". PLOS ONE 13, № 9 (2018): e0204133. http://dx.doi.org/10.1371/journal.pone.0204133.

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Weersink, Robert A., Theo Husby, Ivan Kosik, et al. "Abstract 2523: Porphyrin-lipid nanoparticle-based multifunctional cancer: from cell to patient." Cancer Research 85, no. 8_Supplement_1 (2025): 2523. https://doi.org/10.1158/1538-7445.am2025-2523.

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Abstract Background: Porphysomes (PS) are first-in-class organic porphyrin-lipid nanoparticles with unprecedented intrinsic multifunctionality that enables a range of complementary imaging, image-guided interventions and therapies. Examples are presented in a range of preclinical tumor models, including head & neck, lung and gynecological cancers, demonstrating progress towards first-in-human trials. Methods & Results: High-density packing of the porphyrin-lipid monomers in the nanoparticle bilayer enables efficient light absorption and conversion to heat for enhanced photoacoustic ima

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Ma, Jinyuan, Yang Li, Guihua Liu, et al. "Novel theranostic zinc phthalocyanine–phospholipid complex self-assembled nanoparticles for imaging-guided targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake." Colloids and Surfaces B: Biointerfaces 162 (February 2018): 76–89. http://dx.doi.org/10.1016/j.colsurfb.2017.10.061.

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Yang, Ying, Shuxin Wang, Chen Wang, Chen Tian, Yuhua Shen, and Manzhou Zhu. "Engineered Targeted Hyaluronic Acid–Glutathione‐Stabilized Gold Nanoclusters/Graphene Oxide–5‐Fluorouracil as a Smart Theranostic Platform for Stimulus‐Controlled Fluorescence Imaging‐Assisted Synergetic Chemo/Phototherapy." Chemistry – An Asian Journal 14, no. 9 (2019): 1418–23. http://dx.doi.org/10.1002/asia.201900153.

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Alfano, Massimo, Elisa Alchera, Angelina Sacchi, et al. "Abstract 2381: Gold nanorods functionalized with an alpha5beta1 ligand: a simple and robust nanosystem for early bladder cancer detection." Cancer Research 83, no. 7_Supplement (2023): 2381. http://dx.doi.org/10.1158/1538-7445.am2023-2381.

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Abstract Early detection and removal of bladder cancer (BC) is crucial to prevent tumor recurrence and progression. Various imaging modalities have been used to diagnose BC, including computed tomography urography, intravenous urography, ultrasound echography, multiparametric magnetic resonance imaging, cystoscopy, and cystoscopy in conjunction with intravesical instillation of hexaminolaevulinic acid, a photodynamic diagnostic agent. However, all these imaging techniques show a very poor detection rate of small (&lt;5mm) and flattened cancer lesions. Because of this limitation, patients w

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Nieberler, M., U. Reuning, H. Kessler, F. Reichart, G. Weirich та K. D. Wolff. "Fluorescence imaging of invasive head and neck carcinoma cells with integrin αvβ6-targeting RGD-peptides: an approach to a fluorescence-assisted intraoperative cytological assessment of bony resection margins". British Journal of Oral and Maxillofacial Surgery 56, № 10 (2018): 972–78. http://dx.doi.org/10.1016/j.bjoms.2018.11.003.

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CSCI, _. "CSCI Young Investigators Forum Abstracts." Clinical & Investigative Medicine 32, no. 4 (2009): 1. http://dx.doi.org/10.25011/cim.v32i4.6623.

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ASSESSMENT OF PARALLEL SIGNALING PATHWAYS IN UTERINE MYOCYTES STIMULATED WITH VARIOUS SMOOTH MUSCLE AGONISTS H.N. Aguilar, B.F. Mitchell 1 TRACTOGRAPHY: A NOVEL TECHNIQUE TO IMAGE FIBER TRACTS OF THE SPINAL CORD Fahad Alkherayf, Eve Tsai, Arturo Cardenas-Blanco, Alain Berthiaume, Brien Benoit, John Sinclair 1 MODULATION OF OSTEOCLASTOGENESIS IN INFLAMMATORY JOINT DISEASES H. Allard-Chamard, M. Durant, A.J. de Brum-Fernandes, G. Boire, S.V. Komarova, S.J. Dixon, S.M. Sims, R. Harison, M.F. Manolson 2 “THE RIGHT THING TO DO? A CRITICAL ANALYSIS OF PUBLIC HEALTH ETHICS, RIGHTS DISCOURSE, AND THE

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Duro-Castaño, Aroa, Elena Gallon, Caitlin Decker, and María J. Vicent. "Modulating Angiogenesis with Integrin-Targeted Nanomedicines." Advanced Drug Delivery Reviews, May 12, 2017. https://doi.org/10.1016/j.addr.2017.05.008.

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Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, has become an attractive strategy for the development of efficient guided nanomedicines. In this respect, integrins are cell-adhesion molecules involved in angiogenesis signaling pathways and are overexpressed in many angiogenic processes. Therefore, they represent specific biomarkers not only to monitor disease progression but also to rationally design targeted nanomedicines. Arginine-glycine-aspartic (RGD) containing peptides that bind to specific integrins have been widely utilized to provide l

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Steiger, Katja, Neil Gerard Quigley, Tanja Groll та ін. "There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography". EJNMMI Research 11, № 1 (2021). http://dx.doi.org/10.1186/s13550-021-00842-2.

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Abstract Background In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there are no less than 24 known integrins, and peptides without the RGD sequence as well as non-peptidic ligands play an equally important role as selective integrin ligands. On the other hand, multimerization is a well-established method to increase the avidity of binding structures, but multimeric radiopharmaceuticals have not made their way into clinics yet. In this review

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Liu, Yaqi, Huachun Xu, Shihao Bai, et al. "Nanomaterial-Assisted Pancreatic Cancer Theranostics." Regenerative Biomaterials, June 11, 2025. https://doi.org/10.1093/rb/rbaf054.

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Abstract Pancreatic cancer is one of the most lethal malignancies, largely due to the limitations of current imaging technologies and treatment strategies, which hinder early diagnosis and effective disease management. Achieving precise theranostics for pancreatic cancer has become a priority, and recent advances have focused on the development of novel nanomaterials with enhanced imaging capabilities and therapeutic functionalities. These nanomaterials, through surface modifications, can significantly improve the targeting and precision of both diagnostic and therapeutic applications. Recent

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Yousefnia, Hassan, Fateme Badipa, and Behrouz Alirezaour. "An overview of radiolabeled RGD peptides for theranostic applications." Current Radiopharmaceuticals 16 (December 7, 2022). http://dx.doi.org/10.2174/1874471016666221207122731.

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Abstract: Angiogenesis phenomenon, as a highly affecting factor on the growth and spread of cancer cells, depends on specific molecular interactions between components of the extracellular matrix and vascular cells. αv integrin acts as a cell adhesive molecule involved in tumor invasion and angiogenesis. Among the various combinations of integrin subunits expressed on the surface of cells, αvβ3 integrin has a particularly interesting expression pattern during angiogenesis. The αvβ3 integrin is a vital receptor affecting tumor growth, tumor invasiveness, metastasis, and angiogenesis overexpress

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Armanetti, Paolo, Irene Locatelli, Chiara Venegoni, et al. "Gold nanorod–assisted theranostic solution for nonvisible residual disease in bladder cancer." Proceedings of the National Academy of Sciences 121, no. 37 (2024). http://dx.doi.org/10.1073/pnas.2411583121.

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Residual nonvisible bladder cancer after proper treatment caused by technological and therapeutic limitations is responsible for tumor relapse and progression. This study aimed to demonstrate the feasibility of a solution for simultaneous detection and treatment of bladder cancer lesions smaller than one millimeter. The α5β1 integrin was identified as a specific marker in 81% of human high-grade nonmuscle invasive bladder cancers and used as a target for the delivery of targeted gold nanorods (GNRs). In a preclinical model of orthotopic bladder cancer expressing the α5β1 integrin, the photoaco

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Jin, Fangzhou, Zhiyuan Xu, Wei Wang, et al. "Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe." Small Science, October 31, 2024. http://dx.doi.org/10.1002/smsc.202400450.

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Efficient delivery of photons to visceral organs is critical for the treatment of deep‐seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, an integrated fiber‐optic theranostic (iFOT) probe is developed that merges tumor microenviro

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Khan, Amreen, Faith Dias, Suditi Neekhra, Barkha Singh, and Rohit Srivastava. "Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics." Frontiers in Chemistry 8 (January 29, 2021). http://dx.doi.org/10.3389/fchem.2020.631351.

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Cancer has been widely investigated yet limited in its manifestation. Cancer treatment holds innovative and futuristic strategies considering high disease heterogeneity. Chemotherapy, radiotherapy and surgery are the most explored pillars; however optimal therapeutic window and patient compliance recruit constraints. Recently evolved immunotherapy demonstrates a vital role of the host immune system to prevent metastasis recurrence, still undesirable clinical response and autoimmune adverse effects remain unresolved. Overcoming these challenges, tunable biomaterials could effectively control th

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Wei, Qiaolin, Jian He, Shuaifei Wang, et al. "Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy." Journal of Nanobiotechnology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12951-021-00875-8.

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Abstract Background Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery and bulk accumulation of NPs in tumors are still the decisive factors in improving therapeutic effect. It is urgent to seek other methods to alters tumor microenvironment (like vascular permeability and density) for enhancing the efficiency of nanoparticles delivery and accumulation at the tumor site. Methods Herein, we developed a Raman-tagged hollow gold nanoparticle (termed as HAuNP@D

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Zhao, Shuai, Shan Sun, Kai Jiang, et al. "In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery." Nano-Micro Letters 11, no. 1 (2019). http://dx.doi.org/10.1007/s40820-019-0263-3.

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Abstract Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment. In this work, a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed. Carbon dots (CDs), from folic acid as the raw material, were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles (MSNs–NH2) via a microwave-assisted solvothermal reaction. The as-prepared nanohybrid (designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of M

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Chen, Haoran, Shengnan Liu, Wang Wang, et al. "Synergistic Comprehensive Activation Methods for Dual‐Modality PDT and Hypoxia‐Triggered Chemotherapy Guided by NIR‐II Imaging beyond 1700 nm in Deep Tumors." Small, April 8, 2025. https://doi.org/10.1002/smll.202500553.

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AbstractAlthough photodynamic therapy (PDT) holds great promise for applications in cancer treatment, it has limited effectiveness against deep hypoxic tumors. Moreover, the lack of visualization guidance for precision theranostics poses additional challenges, hindering its broader clinical adoption. By combining NIR‐IIc (1800 nm) imaging guidance with internally and externally activatable dual‐modality PDT and hypoxia‐triggered chemotherapy, this study proposes a conceptual framework to overcome these limitations. This approach involves the use of photoswitchable lanthanide‐doped nanoparticle

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Shi, Yupeng, Yaning Xia, Mengyang Zhou, et al. "Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy." Journal of Nanobiotechnology 22, no. 1 (2024). http://dx.doi.org/10.1186/s12951-024-02360-4.

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AbstractFunctional metal doping endows fluorescent carbon dots with richer physical and chemical properties, greatly expanding their potential in the biomedical field. Nonetheless, fabricating carbon dots with integrated functionality for diagnostic and therapeutic modalities remains challenging. Herein, we develop a simple strategy to prepare Gd/Ru bimetallic doped fluorescent carbon dots (Gd/Ru-CDs) via a one-step microwave-assisted method with Ru(dcbpy)3Cl2, citric acid, polyethyleneimine, and GdCl3 as precursors. Multiple techniques were employed to characterize the morphology and properti

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Gondhane, Abhay, Priyanka Verma, Ashok Chandak, and Sandip Basu. "Prospective evaluation of 68Ga-NODAGA-RGD PET-CT in patients of carcinoma thyroid with thyroglobulin elevated negative radioiodine scintigraphy (TENIS) with a head-to-head comparison with FDG-PET/CT." Nuclear Medicine Communications, March 6, 2024. http://dx.doi.org/10.1097/mnm.0000000000001828.

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Background and aim This study aimed to examine the expression of RGD binding integrins in patients of elevated serum thyroglobulin (Tg) level with negative radioiodine scintigraphy (TENIS) employing 68Ga-NODAGA-RGD PET-CT. Material and methods This was a prospective study involving 30 proven cases of TENIS with histopathological diagnosis of differentiated thyroid carcinoma post-surgery. In addition to observing the lesional concentration on 68Ga-NODAGA-RGD PET-CT, a 4-point visual grading system (grade I–IV), was undertaken to estimate the degree of radiotracer avidity, for potential of thera

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