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Journal articles on the topic 'Isoquinolines, pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

J. LaVoie, Edmond, and Qun Sun. "Synthesis of Benzimidazo[2,1-a]isoquinolines and 5,6-Dihydrobenzimidazo[2,1-a]isoquinolines." HETEROCYCLES 43, no. 4 (1996): 737. http://dx.doi.org/10.3987/com-95-7338.

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2

Dupas, Georges, Jean-François Brière, Guy Quéguiner, and Jean Bourguignon. "Synthesis of Fused Systems in the Isoquinoline Series: Oxazolo- and Pyrrolo[3,2-c]isoquinolines." HETEROCYCLES 52, no. 3 (2000): 1371. http://dx.doi.org/10.3987/com-99-s120.

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3

M. Hassaneen, Hamdi, Mohamed A. M. Teleb, Hyam A. Abdelhadi, Yara N. Laboud, and Fatma M. Saleh. "Synthesis, Antimicrobial and Antitumor Study of New Pyrido[2,1-a]isoquinolines via Isoquinoline-1-acetonitrile." HETEROCYCLES 102, no. 9 (2021): 1729. http://dx.doi.org/10.3987/com-21-14494.

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4

Campagna, Francesco, Angelo Carotti, and Giovanni Casini. "Chemical and Catalytic Reductive Isomerization of [1,3]Oxazino[2,3-a]isoquinolines to [1,3]Oxazino[3,2-b]isoquinolines." HETEROCYCLES 27, no. 1 (1988): 245. http://dx.doi.org/10.3987/com-87-4358.

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5

Tantawy, Mohamed A., Farid M. Sroor, Magda F. Mohamed, et al. "Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer." Anti-Cancer Agents in Medicinal Chemistry 20, no. 1 (2020): 70–83. http://dx.doi.org/10.2174/1871520619666191024121116.

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Background: Chalcones are naturally occurring compounds found in various plant species which are widely used for the traditional popular treatments. Chalcones are distinguished secondary metabolites that are reported to display diverse biological activities such as antiviral, antiplatelet, anti-inflammatory, anticancer, antibacterial and antioxidant agents. The presence of a,ß-unsaturated carbonyl group in chalcones is assumed to be responsible for their bioactivity. In addition, heterocyclic compounds having nitrogen such as isoquinolines are of considerable interest as they constitute the co

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6

Dormidontov, M. Yu, B. Ya Syropyatov, R. Z. Dautova, et al. "Synthesis, antiaggregational and hypotensive activity of some isoquinolines." Pharmaceutical Chemistry Journal 24, no. 12 (1990): 882–85. http://dx.doi.org/10.1007/bf00766580.

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7

Tang, E., Deshou Mao, Qi Sun, Minghong Liao, Yunxia Li та Shanshan Liu. "One-Pot Synthesis of Pyrrolo[2,1-α]isoquinolines via Tandem Reactions of Vinylselenonium Salt, 2-Bromoethanones, and Isoquinoline". HETEROCYCLES 98, № 11 (2019): 1563. http://dx.doi.org/10.3987/com-19-14162.

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8

Tsotinis, A., S. Zouroudis, D. Moreau, and C. Roussakis. "C4-Substituted Isoquinolines: Synthesis and Cytotoxic Action." Open Medicinal Chemistry Journal 1, no. 1 (2007): 1–3. http://dx.doi.org/10.2174/1874104500701010001.

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9

Tsotinis, A., S. Zouroudis, D. Moreau, and C. Roussakis. "C4-Substituted Isoquinolines: Synthesis and Cytotoxic Action." Open Medicinal Chemistry Journal 1, no. 1 (2007): 1–3. http://dx.doi.org/10.2174/187410450701011054.

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10

Hodge Markgraf, J., Thomas Mueller, and Christopher R. Myers. "Strained Heterocycles Systems. 17. Basicities of Selected Isoquinolines." HETEROCYCLES 29, no. 12 (1989): 2399. http://dx.doi.org/10.3987/com-89-5241.

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11

Anikina, L. V., Yu B. Vikharev, Yu S. Rozhkova, and Yu V. Shklyaev. "Synthesis and Biological Activity of 3-Spiro[adamantane-2,3′-isoquinolines]." Pharmaceutical Chemistry Journal 46, no. 12 (2013): 707–10. http://dx.doi.org/10.1007/s11094-013-0874-9.

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12

Mortier, Jérémie, Raphaël Frederick, Corinne Ganeff та ін. "Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation". Biochemical Pharmacology 79, № 10 (2010): 1462–72. http://dx.doi.org/10.1016/j.bcp.2010.01.007.

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13

Yuan, Hai-Lian, Yun-Li Zhao, Xu-Jie Qin, Ya-Ping Liu, Xing-Wei Yang, and Xiao-Dong Luo. "Diverse isoquinolines with anti-inflammatory and analgesic bioactivities from Hypecoum erectum." Journal of Ethnopharmacology 270 (April 2021): 113811. http://dx.doi.org/10.1016/j.jep.2021.113811.

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14

Yamada, Koichiro, and Harumichi Kohno. "A Novel Synthesis of Isoquinolines Containing an Electron Withdrawing Substituent." HETEROCYCLES 51, no. 1 (1999): 103. http://dx.doi.org/10.3987/com-98-8362.

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15

Fukumoto, Keiichiro, Kozo Shishido, Kou Hiroya, and Tetsuji Kametani. "A Convenient Access to 3,4-Disubstituted Isoquinolines from Benzocyclobutenyl Ketoximes." HETEROCYCLES 28, no. 1 (1989): 39. http://dx.doi.org/10.3987/com-88-s15.

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16

A. Joule, John, David A. Peters, Nicholas D. Yates, and David I. C. Scopes. "Synthesis of 5,7,8,9,10,11-Hexahydro-7-oxo-8,11-iminoazepino[1,2-b]isoquinolines." HETEROCYCLES 40, no. 2 (1995): 983. http://dx.doi.org/10.3987/com-94-s99.

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17

Chen, Chien-Kuang, Su-Chang Chen, Chung-Hsiung Chen, and Shoei-Sheng Lee. "Isoquinoline Alkaloids from the Leaves of Dehaasia Hainanensis." Natural Product Communications 2, no. 1 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200115.

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This study was aimed at investigating the alkaloids present in the leaves of Dehaasia hainanensis. Thirteen isoquinolines were isolated and characterized. Of these, four aporphines [(+)-laurolitsine, (+)-corydine, (+)-laurotetanine and (+)-lindcarpine], two morphinans [(-)-sinoacutine and (-)-ocobotrine], four benzylisoquinolines [(+)-reticuline, (+)-roefractine, (+)-reticuline N-oxide, and O-methylarmepavine], and one bisbenzylisoquinoline [(-)-N,N'-dimethyllindoldhamine] are reported for the first time from Dehaasia species. The structures were elucidated by spectral analysis.

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18

Airapetyan, G. K., Zh S. Arustamyan, R. E. Markaryan, et al. "Isoquinolines. XXVIII. Synthesis and biological activity of N-substituted 6,7-dimethoxy-4-spiroisoquinolines." Pharmaceutical Chemistry Journal 24, no. 5 (1990): 355–58. http://dx.doi.org/10.1007/bf00766253.

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19

R殀er, Wolfgang, and Elmar Konz. "Synthesis and Reactions of Isoquinolines IV. Reactions of 3-Chloroisoquinoline-4-carbaldehydes." HETEROCYCLES 29, no. 4 (1989): 691. http://dx.doi.org/10.3987/com-89-4821.

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20

Rigo, Benoît, Rufine Akué-Gédu, Anne Bourry, et al. "Allylic Dehydration, Retro-Pinacol, Pinacol-like and Enamide Reactions: Synthesis of New Isoquinolines." HETEROCYCLES 63, no. 8 (2004): 1855. http://dx.doi.org/10.3987/com-04-10134.

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21

Párraga, Javier, Abraham Galán, Maria Jesús Sanz, Nuria Cabedo, and Diego Cortes. "Synthesis of hexahydrocyclopenta[ij]isoquinolines as a new class of dopaminergic agents." European Journal of Medicinal Chemistry 90 (January 2015): 101–6. http://dx.doi.org/10.1016/j.ejmech.2014.11.009.

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22

Azzena, Ugo, Luisa Pisano, and Mario Pittalis. "Alkali Metal-mediated Synthesis of 1- and 4-Substituted N-Alkyl-1,2,3,4-tetrahydro- isoquinolines." HETEROCYCLES 63, no. 2 (2004): 401. http://dx.doi.org/10.3987/com-03-9936.

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23

Maiti, Subhadip, Puja Saha, Tania Das, Irene Bessi, Harald Schwalbe, and Jyotirmayee Dash. "Human Telomeric G-Quadruplex Selective Fluoro-Isoquinolines Induce Apoptosis in Cancer Cells." Bioconjugate Chemistry 29, no. 4 (2018): 1141–54. http://dx.doi.org/10.1021/acs.bioconjchem.7b00781.

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24

Humphreys, Benjamin D., Caterina Virginio, Annmarie Surprenant, Janet Rice, and George R. Dubyak. "Isoquinolines as Antagonists of the P2X7Nucleotide Receptor: High Selectivity for the Human versus Rat Receptor Homologues." Molecular Pharmacology 54, no. 1 (1998): 22–32. http://dx.doi.org/10.1124/mol.54.1.22.

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25

José Alves, M., Nuno G. Azoia, and A. Gil Fortes. "Synthesis of 1,3,8,8a-Tetrahydro-3,8-epoxyazirino[1,2-b]isoquinolines and Their Reactions with Oxygen Nucleophiles." HETEROCYCLES 65, no. 6 (2005): 1329. http://dx.doi.org/10.3987/com-05-10365.

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26

Honda, Toshio, and Hiroki Shigehisa. "Unexpected Unique Behavior of Spiro-Isoquinolines with a Cyclohexadienone System in Attempted Dienone-Phenol Rearrangement." HETEROCYCLES 75, no. 5 (2008): 1233. http://dx.doi.org/10.3987/com-07-11308.

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27

Myers, R. D. "Isoquinolines, beta-carbolines and alcohol drinking: Involvement of opioid and dopaminergic mechanisms." Experientia 45, no. 5 (1989): 436–43. http://dx.doi.org/10.1007/bf01952025.

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28

J. Estévez, Ramón, Jacobo Cruces, Juan C. Estévez, and Luis Castedo. "New Synthetic Applications of Phenylacetylphenylacetic Acids: A Divergent Synthesis of Benzo[a]carbazoles and Indolo[2,1-a]isoquinolines." HETEROCYCLES 53, no. 5 (2000): 1041. http://dx.doi.org/10.3987/com-99-8838.

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29

Yamamoto, Yutaka, Yasuo Morita, and Osamu Ohmukai. "A Versatile New Method for Synthesis of Isoquinolines; 6,8-Dihydroxyisoquinoline Derivatives from 6-Methyl-1,3-oxazin-4-ones." HETEROCYCLES 33, no. 2 (1992): 515. http://dx.doi.org/10.3987/com-91-s75.

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30

Barbolla, Iratxe, Leidi Hernández-Suárez, Viviana Quevedo-Tumailli, et al. "Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents." European Journal of Medicinal Chemistry 220 (August 2021): 113458. http://dx.doi.org/10.1016/j.ejmech.2021.113458.

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31

Yan, Yumei, Xing Li, Chunhong Zhang, Lijuan Lv, Bing Gao, and Minhui Li. "Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review." Antibiotics 10, no. 3 (2021): 318. http://dx.doi.org/10.3390/antibiotics10030318.

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Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants. They represent one of the most important types of natural products because of their large number and structural diversity and complexity. Based on their chemical core structures, alkaloids are classified as isoquinolines, quinolines, indoles, piperidine alkaloids, etc. In-depth analyses of alkaloids have revealed their antibacterial activities. To date, due to the widespread use of antibiotics, the problem of drug-resistant bacterial infections has been gradually increasing, which severely affects the clin

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32

Liu, Cheng-Mei, Fei-Hua Yao, Xin-Hua Lu, et al. "Isoquinoline Alkaloids as Protein Tyrosine Phosphatase Inhibitors from a Deep-Sea-Derived Fungus Aspergillus puniceus." Marine Drugs 20, no. 1 (2022): 78. http://dx.doi.org/10.3390/md20010078.

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Puniceusines A–N (1–14), 14 new isoquinoline alkaloids, were isolated from the extracts of a deep-sea-derived fungus, Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses. The absolute configuration of 9 was determined by ECD calculations, and the structures of 6 and 12 were further confirmed by a single-crystal X-ray diffraction analysis. Compounds 3–5 and 8–13 unprecedentedly contained an isoquinolinyl, a polysubstituted benzyl or a pyronyl at position C-7 of isoquinoline nucleus. Compounds 3 and 4 showed selective inhibitory activity against protein ty

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33

J. Schmiesing, Richard, and James R. Matz. "New Atypical Antidepressants: An Efficient Process for Preparing cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-aryl-2H-pyrazino[2,1-a]isoquinolines." HETEROCYCLES 29, no. 2 (1989): 359. http://dx.doi.org/10.3987/com-89-4777.

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34

Jin, Tian-Yun, Shao-Qiang Li, Cui-Rong Jin та ін. "Catecholic Isoquinolines from Portulaca oleracea and Their Anti-inflammatory and β2-Adrenergic Receptor Agonist Activity". Journal of Natural Products 81, № 4 (2018): 768–77. http://dx.doi.org/10.1021/acs.jnatprod.7b00762.

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35

Nagasaka, Tatsuo, Yuji Koseki, Hidefumi Ozawa, et al. "Synthesis of Optically Active Tetrahydro-3-benzazepine-2-carboxylic Acid Derivatives via the Ring Expansion Reaction of Isoquinolines and Enzymatic Resolution." HETEROCYCLES 63, no. 1 (2004): 17. http://dx.doi.org/10.3987/com-03-9928.

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36

Lehmann, Jochen, Robert Otto, and Christoph Enzensperger. "Synthesis and Biological Activity of Novel Heterocyclic Ring Systems: Imidazo[4’,5’:3,4]pyrido[2,1-a]isoquinolines and Imidazo[4,5-f][3]benzazecines." HETEROCYCLES 87, no. 3 (2013): 551. http://dx.doi.org/10.3987/com-12-12574.

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37

R. Burke, Jr., Terrence, Pamela L. Russ, and Victor E. Marquez. "A New Synthetic Method for the Synthesis of Hydroxylated Isoquinolines: Preparation of Methyl 6,7- and 7,8-Dihydroxyisoquinoline-3-carboxylates, Potential Protein-Tyrosine Kinase Inhibitors." HETEROCYCLES 34, no. 4 (1992): 757. http://dx.doi.org/10.3987/com-91-5958.

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38

Paronikyan, E. G., Sh Sh Dashyan, A. S. Noravyan, et al. "Synthesis and Neurotropic Activity of Amino Derivatives of Cyclopenta[4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d ]pyrimidines and Pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines." Pharmaceutical Chemistry Journal 50, no. 5 (2016): 301–5. http://dx.doi.org/10.1007/s11094-016-1440-z.

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39

Ali, Farak, Shahnaz Alom, and Md Kamaruz Zaman. "Berberine: A Comprehensive Review on its Isolation, Biosynthesis, Chemistry and Pharmacology." Asian Journal of Chemistry 33, no. 11 (2021): 2548–60. http://dx.doi.org/10.14233/ajchem.2021.23365.

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The isoquinoline compounds from alkaloidal class have been excellent source of important phytoconstituents having wide range of pharmacological activities. Berberine is a protoberberine alkaloidal compound obtained from Berberis genus plants which belongs to family Barberidaceae. Due to its unique structural properties, berberine and its derivatives has been exploited extensively for its potential uses in various pharmacological targets such as cancer, inflammation, diabetes, gastrointestinal disorder, viral and microbial infections, neurological disorder like Alzheimer, anxiety, schizophrenia

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40

R. Biehl, Edward, and U. Narasimha Rao. "Convenient Synthesis of 3H-Pyrrolo[2,3-c]isoquinolines and 3H-Pyrrolo[2,3-c][1,7]-, 3,4-Benzo[c][1,7]-, and Dihydropyrido[4,3-c][1,8]naphthyridines via Palladium-assisted Nucleophilic Amination." HETEROCYCLES 56, no. 1-2 (2002): 443. http://dx.doi.org/10.3987/com-01-s(k)68.

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41

Hidaka, Hiroyoshi, and Masatoshi Hagiwara. "Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors." Trends in Pharmacological Sciences 8, no. 5 (1987): 162–64. http://dx.doi.org/10.1016/0165-6147(87)90155-6.

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42

M. Al-Matar, Hamad, Khaled D. Khalil, and Mohamed H. Elnagdi. "Alkylheteroaromatic-carbonitriles as Building Blocks in Heterocyclic Synthesis: Synthesis of Ethyl 1-Substituted 5-Cyano-4-methyl-6-oxopyridine-3-carboxylates; Versatile Precursors for Polyfunctionally Substituted Isoquinolines and Pyrido[3,4-c]pyridine." HETEROCYCLES 78, no. 8 (2009): 2067. http://dx.doi.org/10.3987/com-09-11685.

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43

Magarian, R. A., L. B. Overacre, S. Singh, and K. L. Meyert. "The Medicinal Chemistry of Nonsteroidal Antiestrogens: A Review." Current Medicinal Chemistry 1, no. 1 (1994): 61–104. http://dx.doi.org/10.2174/0929867301666220210212635.

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Abstract: The inhibition of estrogen is a particularly useful strategy for the treatment of hormone-dependent breast tumors in postmenopausal females and possibly in premenopausal women and as a chemosuppressive in women at high risk of developing breast cancer. Nonsteroidal antiestrogens which exhibit potent antitumor effects represent a major advance in the management of breast cancer. Considerable effort by many research groups has been devoted to the search for novel pure nonsteroidal antiestrogens with the hope of finding antitumor agents that would be useful in estrogen receptor (ER) pos

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44

Yang, Yang, Tingyu Ding, Gang Xiao та ін. "Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1–CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice". Biomedicines 11, № 2 (2023): 464. http://dx.doi.org/10.3390/biomedicines11020464.

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Allocryptopine (ALL) is an isoquinoline alkaloid extracted from Macleaya cordata (Willd). R. Br., which has been claimed to have anti-inflammatory and neuroprotection properties. However, the mechanism by which ALL ameliorates inflammatory bowel disease (IBD) remains unclear. Here, we used network pharmacology and quantitative proteomic approaches to investigate the effect of ALL on IBD pathogenesis. Network pharmacology predicted potential targets and signaling pathways of ALL’s anti-IBD effects. As predicted by network pharmacology, gene ontology (GO) analysis, in terms of the proteomic resu

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45

Zhang, Yangyang, Yun Kang, Hui Xie, Yaqin Wang, Yaoting Li, and Jianming Huang. "Comparative Transcriptome Analysis Reveals Candidate Genes Involved in Isoquinoline Alkaloid Biosynthesis in Stephania tetrandra." Planta Medica 86, no. 17 (2020): 1258–68. http://dx.doi.org/10.1055/a-1209-3407.

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AbstractThe roots of Stephania tetrandra are used as a traditional Chinese medicine. Isoquinoline alkaloids are considered to be the most important and effective components in this herb, but little is known about the molecular mechanism underlying their biosynthesis. In this context, this study aimed to reveal candidate genes related to isoquinoline alkaloid biosynthesis in S. tetrandra. Determination of tetrandrine and fangchinoline in the roots and leaves of S. tetrandra by HPLC showed that the roots had much higher contents of the two isoquinoline alkaloids than the leaves. Thus, a comparat

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46

Zhou, Shengbin, Yanan Duan, Jiang Wang, et al. "Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes." European Journal of Medicinal Chemistry 140 (November 2017): 448–64. http://dx.doi.org/10.1016/j.ejmech.2017.09.012.

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47

Cordell, Geoffrey A. "The Simple Plant Isoquinolines By Alexander T. Shulgin and Wendy E. Perry. Transform Press, Berkeley, CA. 2002. xxxv + 624 pp. 16 × 23.5 cm. $40.00. ISBN 0-9630096-2-1." Journal of Natural Products 66, no. 6 (2003): 902. http://dx.doi.org/10.1021/np0307035.

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48

FOREMAN, M. I., M. TAYLOR, C. CLARK, et al. "Pharmacology and Treatment Isoquinoline is a possible anti-psoriatic agent in coal tar." British Journal of Dermatology 112, no. 3 (1985): 323–28. http://dx.doi.org/10.1111/j.1365-2133.1985.tb04860.x.

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49

Raza, Adnan. "A Review of the Phytochemistry, Pharmacology, and Traditional Applications of Cissampelos Pareira." International Journal for Research in Applied Science and Engineering Technology 12, no. 12 (2024): 10–17. https://doi.org/10.22214/ijraset.2024.65481.

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In Indian traditional medicine, Cissampelos pareira, is a perennial climbing herb that is a member of the Menispermaceae family and is referred to as Ambastha or Laghu Patha. A review of the literature shows that C. pareira's phytochemistry and pharmacology have advanced significantly, indicating the plant's enormous therapeutic potential. Numerous pharmacological effects, including antipyretic, anti-inflammatory, antiarthritic, antiulcer, antidiabetic, anticancer, antifertility, antibacterial, antioxidant, antivenom, antimalarial, and immunomodulatory properties, have been demonstrated by the

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50

Qing, Zhi-Xing, Jia-Lu Huang, Xue-Yi Yang, et al. "Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship." Current Medicinal Chemistry 25, no. 38 (2019): 5088–114. http://dx.doi.org/10.2174/0929867324666170920125135.

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The severe anticancer situation as well as the emergence of multidrug-resistant (MDR) cancer cells has created an urgent need for the development of novel anticancer drugs with different mechanisms of action. A large number of natural alkaloids, such as paclitaxel, vinblastine and camptothecin have already been successfully developed into chemotherapy agents. Following the success of these natural products, in this review, twenty-six types of isoquinoline alkaloids (a total of 379 alkaloids), including benzyltetrahydroisoquinoline, aporphine, oxoaporphine, isooxoaporphine, dimeric aporphine, b

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