Relevant bibliographies by topics / Lead(n) derivatives

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Lead(n) derivatives'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Lead(n) derivatives"

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Sanjay, Mathur, and Singh Anirudh. "Investigations on homo- and hetero-leptic isopropoxometallates of lead(II)." Journal of Indian Chemical Society Vol. 88, Nov 2011 (2011): 1673–78. https://doi.org/10.5281/zenodo.5791624.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>Manuscript received 19 July 2010, revised 11 April 2011, accepted 20 April 2011</em> Novel homo- and hetero-leptic isopropoxometallates of lead(ll) of the types [{{Zr<sub>2</sub>(OPr1)<sub>9</sub>}Pb(&micro;-F))}<sub>2</sub>] (la), [{{Nb(OPr<sup>i</sup>)<sub>6</sub>}Pb(&micro;-F)}<sub>2</sub>] (lb), [{{AI(OPr<sup>i</sup>)<sub>4</sub>}Pb(&micro;-F)}<sub>2</sub>] (lc), [{{Sn<sub>2</sub>(OPr<sup>i</sup>)<sub>9</sub>}Pb(&micro;-F)}<sub>2</sub>] (1d), [Pb{Zr<sub>2</sub>(OPr<sup>i</sup>)<sub>9</sub>}<sub>2</sub>]
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Khan, Momin, Ghulam Ahad, Ajmal Khan, et al. "Antiglycation Activity of N, N-Diethylthiobarbiturates Derivatives." Letters in Drug Design & Discovery 17, no. 4 (2020): 411–17. http://dx.doi.org/10.2174/1570180816666190516111516.

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Background: Previous identification of N,N-diethylthiobarbiturates as potential α-glucosidase inhibitory potential prompted us to investigate the antiglycation activity of these synthetic compounds (1-25) in order to identify the lead candidates for their possible antidiabetic potential. Methods: Synthetic compounds (1-25) were evaluated for their antiglycation activity using Bovine Serum Albumin assay (BSA). Results: Compounds exhibited varying degree of inhibition in the range of IC50 = 61.16 ± 2.3 - 656.71 ± 2.5 µM as compared to the standard rutin (IC50 = 294.5 ± 1.50 µM). Among the twenty
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Pyanylo, Yaroslav, and Galyna Pyanylo. "Analysis of approaches to mass-transfer modeling n non-stationary mode." Physico-mathematical modelling and informational technologies, no. 28, 29 (December 27, 2019): 55–64. http://dx.doi.org/10.15407/fmmit2020.28.055.

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A significant number of natural and physical processes are described by differential equations in partial derivatives or systems of differential equations in partial derivatives. Numerical methods have been found to find their solutions. Partial derivatives systems are solved mainly by reducing the order of the system of equations or reducing it to one differential equation. This procedure leads to an increase in the order of the differential equation. There are various restrictions and errors that can lead to additional solutions, boundary conditions for intermediate derivatives, and so on. T
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Balakina, Anastasia, Svyatoslav Gadomsky, Tatyana Kokovina, Tatyana Sashenkova, Denis Mishchenko, and Alexei Terentiev. "New Derivatives of N-Hydroxybutanamide: Preparation, MMP Inhibition, Cytotoxicity, and Antitumor Activity." International Journal of Molecular Sciences 24, no. 22 (2023): 16360. http://dx.doi.org/10.3390/ijms242216360.

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Using a novel method of N-substituted succinimide ring opening, new N-hydroxybutanamide derivatives were synthesized. These compounds were evaluated for their ability to inhibit matrix metalloproteinases (MMPs) and their cytotoxicity. The iodoaniline derivative of N1-hydroxy-N4-phenylbutanediamide showed the inhibition of MMP-2, MMP-9, and MMP-14 with an IC50 of 1–1.5 μM. All the compounds exhibited low toxicity towards carcinoma cell lines HeLa and HepG2. The iodoaniline derivative was also slightly toxic to glioma cell lines A-172 and U-251 MG. Non-cancerous FetMSC and Vero cells were found
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Heuger, Gerold, and Richard Göttlich. "Intermolecular addition reactions of N-alkyl-N-chlorosulfonamides to unsaturated compounds." Beilstein Journal of Organic Chemistry 11 (July 21, 2015): 1226–34. http://dx.doi.org/10.3762/bjoc.11.136.

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N-Alkyl-N-chlorosulfonamides add to alkenes under copper(I) catalysis. In reactions of styrene derivatives with terminal double bonds the addition products were obtained in excellent yield and high regioselectivity. Lower yields are obtained in addition reactions to non-aromatic alkenes. The reaction most likely proceeds via a redox catalysis and amidyl radicals, a concerted mechanism has been ruled out and a polar mechanism via chloronium ions would lead to the opposite regiochemistry.
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Wang, Jianing, Huinan Yu, Tianchen Fu, et al. "Wide band gap pyromellitic diimides for photo stable n-channel thin film transistors." Journal of Materials Chemistry C 8, no. 22 (2020): 7344–49. http://dx.doi.org/10.1039/d0tc00862a.

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Derkatch, Irina L., Michael E. Bradley, Ping Zhou, Yury O. Chernoff, and Susan W. Liebman. "Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI + ] Prion in Saccharomyces cerevisiae." Genetics 147, no. 2 (1997): 507–19. http://dx.doi.org/10.1093/genetics/147.2.507.

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It has previously been shown that yeast prion [PSI + ] is cured by GuHCl, although reports on reversibility of curing were contradictory. Here we show that GuHCl treatment of both [PSI + ] and [psi – ] yeast strains results in two classes of [psi – ] derivatives: Pin+, in which [PSI + ] can be reinduced by Sup35p overproduction, and Pin–, in which overexpression of the complete SUP35 gene does not lead to the [PSI + ] appearance. However, in both Pin+ and Pin– derivatives [PSI + ] is reinduced by overproduction of a short Sup35p N-terminal fragment, thus, in principle, [PSI + ] curing remains
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Zabula, Alexander V., Andrey Yu Rogachev, and Robert West. "Self-Assembly of N-Heterocyclic Derivatives of Divalent Germanium, Tin, and Lead." Chemistry - A European Journal 20, no. 50 (2014): 16652–56. http://dx.doi.org/10.1002/chem.201405062.

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Hassenrück, Jessica, and Valentin Wittmann. "Cyclopropene derivatives of aminosugars for metabolic glycoengineering." Beilstein Journal of Organic Chemistry 15 (March 4, 2019): 584–601. http://dx.doi.org/10.3762/bjoc.15.54.

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Cyclopropenes have been proven valuable chemical reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels–Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reaction, allowing their visualization in biological systems. Here, we present a comparative study of six cyclopropene-modified hexosamine derivatives and their suitability for MGE. Three mannosamine derivatives in which the cyclopropene moiety is attached to the sugar by either an amide or a carbamate linkage and that differ by the presence or absence of
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Bautista-Aguilera, Óscar M., José M. Alonso, Marco Catto, et al. "N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases." Molecules 27, no. 21 (2022): 7437. http://dx.doi.org/10.3390/molecules27217437.

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Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular level. Given the limited therapeutic success of approved drugs, it is imperative to explore rationally supported therapeutic approaches to combat this disease. The search for novel scaffolds that bind to different receptors and inhibit AD disease-related enzymes could lead to new therapeutic solutions.
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Dissertations / Theses on the topic "Lead(n) derivatives"

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Huang, Shi-Zong, and 黃仕宗. "Preparation of Various Quinone Derivatives with the Assistance of Silver Carbonate via C-H Functionalization and Leads to the Formations of C-N and C-P Bonds." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/b9xdm5.

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碩士<br>國立中興大學<br>化學系所<br>104<br>In this work, the synthesis and characterization of several quinone derivatives with specific configurations were described. Stoichiometric amount of silver carbonate was employed and the C-H activation on the quinone was observed. Crystal structures of several newly-made quinone derivatives were determined by X-ray diffraction methods. These novel quinone derivatives having both phosphine group(s) and amine functional group(s) might act as P,N-bidentate ligands toward transition metals and form metal-containing pre-catalysts. The potential of these pre-catalysts
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Books on the topic "Lead(n) derivatives"

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Sherwood, Dennis, and Paul Dalby. Thermodynamics and mathematics. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198782957.003.0004.

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Most school mathematics is about how one variable, y, varies with respect to one other variable, x, according to an equation such as y = 3x2. Equations like this underpin the student’s knowledge of algebra, and differential and integral calculus. Thermodynamics, however, is necessarily about how a variable, such as the pressure P, varies with respect not to one but to three variables simultaneously – for example, the mole number n, the volume V, and the temperature T. This makes the algebra of thermodynamics more complex, and also implies that mutual changes between pairs of variables is descr
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Book chapters on the topic "Lead(n) derivatives"

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Jays, Judy, P. Parasuram, and J. Saravanan. "Screening of Some Novel Isoxazoles Against C. Albicans for their Potential Use as antifungals: A Computational Approach." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00103.

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Antifungal resistance represents a major challenge for treating invasive fungal infections due to the limited arsenal of systemic antifungal agents. Azole resistance among Candida and Aspergillus species and the spread of such species is alarming. Isoxazoles play a significant role in the field of medicinal chemistry. The great interest associated with this class of compounds is their versatility as synthetic intermediates. Isoxazole derivatives were found to possess anti-bacterial, anti-fungal, anti-inflammatory, pesticidal and herbicidal activities. This study focuses on screening some novel
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Farr, Christine J. "Chromosome fragmentation in vertebrate cell lines." In Chromosome Structural Analysis. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199636990.003.0010.

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Abstract Experimental approaches to understanding chromosome structure and function fall into two main categories: the first involves assembling candidate DNA elements in vitro to construct an artificial chromosome. This approach was used to create yeast artificial chromosomes in both Saccharomyces cerevisiae and Schizosaccharomyces pombe. More recently a related approach has lead to the generation of mammalian minichromosomes in the human somatic cell line HT1080, although the precise DNA organization and requirements of these mammalian minichromosomes has yet to be fully elucidated (1). The
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Barrett, Graham c. "Mono- and di-alkylation of the amino group." In Amino Acid Derivatives. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780198558538.003.0004.

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Abstract The prolonged reaction of an amino acid in solution with an alkyl halide leads to mixtures of secondary and tertiary amines. Continued alkylation ultimately generates the corresponding quaternary ammonium salt of the amino acid ester. This is an inefficient process in terms of organic synthesis, and reliable routes to N-alkylamino acids call for a more painstaking, less direct, approach. Reaction of an amino acid with an aldehyde, followed by reduction of the resulting alkylol or Schiff base, has been found to be reliable, although it is not often used. Weinreb and co-workers showed t
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"Alkyl chain-dependent modulation of blood-brain barrier permeability in N-aryl-tetrahydroisoquinolines." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.21.1.

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Alzheimer disease (AD) is an irreversible progressive neurodegenerative disease that causes failure of cerebral neurons and disability of the affected person to practice normal daily life activities. Despite extensive research efforts, no effective drug capable of significantly slowing or halting neurodegenerative processes has been developed. One of the main challenges in AD drug development is ensuring that therapeutic compounds can efficiently cross the blood-brain barrier (BBB) and reach adequate concentrations in the central nervous system (CNS). This ability is largely influenced by a mo
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Tiwari, Bindu, Mittali Maheshwari, Altaf Hussain, Ram Pratap Pandey, and Nazar Hussain. "Introduction to Glycals." In Glycals and their Derivatives. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815322798125010004.

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Glycals are 1,2-unsaturated sugars having a C=C bond between C-1 and C-2 of the pyranose or furanose moieties of the carbohydrate scaffold. The presence of a C=C bond leads to enhanced reactivity. They are used as chiral building blocks in the synthesis of various natural products and medicinally significant molecules. There are numerous methods for the synthesis of exo-glycals and endo-glycals, such as glycosidations, reagent-based methods, and electrochemical methods. Glycals have shown their versatility and applicability in chemical synthesis in many ways e.g., epoxidation, cycloaddition, a
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Thangaraj, Parimelazhagan, Pezzuto M. John, Tamara P. Kondratyuk, Eun-Jung Park, Murugan Rajan, and Simeon O. Kotchoni. "Inhibition of Nitric Oxide and Free Radical Production by Leaf and Stem Extracts of Psychotria nilgiriensis." In Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238549124010008.

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Psychotria nilgiriensis was used in traditional medicine as to cure chronic inflammatory diseases. Therefore, the evaluation of different combination of solventbased fractions from stem and leaves of P. nilgiriensis for free radical scavenging activity, inhibitory potential against nitric oxide radicals, and tentative identification of active metabolites were carried out. The antioxidant activity of solvent extracts was determined by DPPH· scavenging, TAC, and ORAC assays using spectrophotometer analysis. Further, nitric oxide production inhibition was studied in lipopolysaccharide (LPS)-activ
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Rahman, Q. I., and G. Schmeisser. "Derivative estimates on the unit disc." In Analytic Theory of Polynomials. Oxford University PressOxford, 2002. http://dx.doi.org/10.1093/oso/9780198534938.003.0014.

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Abstract Let there be given a polynomial of degree at most n and some meaningful information about the kind of values it takes on a prescribed subset ε of the complex plane. What can we say about the size of its derivative? It will soon become clear that this question is closely related to the one considered in the two preceding chapters. The special case of the problem where ε is the unit circle is particularly interesting, and has received a good deal of attention. This is partly because it leads us in a natural way to the consideration of a similar question about trigonometric polynomials a
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Sergeevna Ageeva, Liliya, Nikolai Alekseevich Borsch, and Nikolay Vladimirovich Kuvardin. "2(4)-Aminopyridines as Ligands in the Coordination and Extraction Chemistry of Platinum Metals." In Exploring Chemistry with Pyridine Derivatives. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.106376.

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The specific behavior of aromatic amines in the coordination and extraction processes of isolation and separation of platinum and other metals is discussed using the example of 2(4)-aminopyridines (2(4)-AP). As intrasphere ligands, 2(4)-AP have a high electron-donor capacity due to the pumping of an easily polarizable π-electron density. The chemistry of the extraction of platinum metals, iridium in particular, is considered: depending on the conditions, ion associates, coordination-solvated compounds or compounds containing an amine in the inner and outer coordination sphere of the metal are
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Schweitzer, George K., and Lester L. Pesterfield. "The Carbon Group." In The Aqueous Chemistry of the Elements. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195393354.003.0010.

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The elements which constitute the Carbon Group of the Periodic Table are carbon C, silicon Si, germanium Ge, tin Sn, and lead Pb. All five of the elements have atoms characterized by an outer electron structure of ns2np2 with n representing the principal quantum number. This electron arrangement signals the possibility of oxidation states of IV and II. Such is the case with the II oxidation state becoming more stable from C to Pb. As one descends the group, there is a marked change from non-metallic (C) to metallic character (Pb). Reflecting very high ionization energies, C, Si, and Ge do not
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Bolduc, T. G., B. Thomson, and G. M. Sammis. "2.8 Selective Radical Fluorinations." In Free Radicals: Fundamentals and Applications in Organic Synthesis 2. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/sos-sd-233-00149.

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AbstractFluorine atoms are found in numerous industrially relevant materials, including pharmaceuticals, agrochemicals, and plastics. In the pharmaceutical industry alone, more than 20% of all therapeutics and a majority of the top-grossing drugs contain fluorine. The ubiquity of fluorinated compounds in industry has necessitated the development of new methods for selective fluorination. Historically, selective fluorination has relied upon electrophilic or nucleophilic processes. Recent breakthroughs in the discovery of mild radical fluorine-transfer reagents have led to a renaissance in selec
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Conference papers on the topic "Lead(n) derivatives"

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Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

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Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM
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Carlucci, Elisa, and Leonardo Tognarelli. "Preventive Maintenance and Spare Parts Management Optimization in Natural Gas Pipelines Operating Under Variable Conditions Across the Year." In ASME 2015 Power Conference collocated with the ASME 2015 9th International Conference on Energy Sustainability, the ASME 2015 13th International Conference on Fuel Cell Science, Engineering and Technology, and the ASME 2015 Nuclear Forum. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/power2015-49326.

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Pipeline architecture consists in several stations in series configuration; hence the unavailability of one station impacts the availability of the whole pipeline. This lead to the need of optimizing the availability of each station in terms of configuration and number of units required in order to be able of satisfying the demand at any time. The loss of production cost in gas supply application is very high. Aero-derivatives gas Turbines are typically used as drivers in pipeline applications since they maximize train efficiency, minimizing gas consumption. PGT25+ aero-derivative Gas Turbines
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Agrawal, Om Prakash. "Lagrangian and Lagrange Equation of Motion for Fractionally Damped Systems." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0524.

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Abstract Damping properties of various materials have recently been used as active and passive control parameters in smart structures. In these applications, the damping force is considered as proportional to velocity. In recent years, many investigators have demonstrated that the damping characteristics of a material can be modeled more accurately using a fractional derivative. Traditionally, Newton’s law is used to model such nonconservative systems, and when a Lagrangian, Hamiltonian, variational or other energy based approach is used, it is modified so that the resulting equations match wi
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Azzam, R. M. A., and Abdalla M. Alnajjar. "Bare and thin film-coated substrates with maximally flat reflectance vs angle of incidence curve for incident unpolarized light." In OSA Annual Meeting. Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.tur5.

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For any optically isotropic bare or coated substrate the power reflectance R v (ϕ) is an even function, R v (–ϕ) = R v (ϕ), of the angle of incidence ϕ, hence all the odd-numbered derivatives R v ( n ) = d n R v / d ϕ n are identically 0 at ϕ = 0, independent of the incident polarization v. For a bare substrate and incident unpolarized light (v = u), the second derivative R u ( 2 ) also, so that the flatness of the R u vs ϕ curve, from ϕ = 0 up to a large angle (&gt;45°) is determined by the fourth derivative R u ( 4 ) . The condition that R u ( 4 ) = 0 gives the maximally flat response (MFR)
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Ciocarlan, Alexandru, Lidia Lungu, Svetlana Blaja, Kaleria Kuchkova, and Aculina Aricu. "Photochemical transformation of some (+)-Larixol derivatives." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab02.

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n terms of synthetic potential, (+)-larixol 1 outperform other labdanic diterpenoids due to the hydroxyl group at the C6 position. Over the years, various chemical transformations have been performed on the basis of this compound, selectively or on both hydroxyl groups, or by modifying of the side chain [1-4]. Unlike the syntheses mentioned above, only a few are known with the preservation of the side chain or its rearrangement and functionalization in cycle B [5,6]. Herein, the syntheses of (+)-larixol 1 derivatives with an advanced degree of functionalization of the B cycle and preservation
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Shekhar Jha, Himanshu, and W. John Lee. "Does the Chow Pressure Group Analysis Provide Any New Information in the RTA of Unconventional Reservoirs?" In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210481-ms.

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Abstract This study presents a thorough mathematical analysis of Chow Pressure Group (CPG) for unconventional reservoirs exhibiting characteristic power-law behavior and demonstrates that the CPG analysis yields the same results that traditional rate transient analysis (RTA) provides using the log-log plot between rate-normalized pressure (RNP) vs. material balance time (MBT) and Cartesian plot between RNP and timen, where n is the flow exponent. CPG analysis was proposed for flow regime identification, power-law decline-curve analysis, predicting long-term well performance from choked-back we
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Garci´a-Masia´, Carlos. "Determination of the Polynomial Transmission Function: Application to the Transmission of Gears." In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49466.

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The simulation of the operating conditions of transmission gear is strongly influenced by the inevitable presence of various types of errors and/or tolerances, manufacturing processes and assembly, in the kinematic simulation. As a result, the path of contact moves from the theoretical position and appear transmission errors, increasing overload dynamics and the level of noise and vibration. The presence of errors produced that the position angle of the gear with respect to pinion differs from the theoretical transmission ratio, in general there is a delay in the gear, which generates: 1) loss
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Van de Water, A., R. Xhonneux, and F. De Clerck. "ANTI-THROMBOTIC EFFECT IN CANINE CORONARY ARTERIES OF A COMBINED TXA2 synthetase/TXA2-prostaglandin ENDOPEROXIDE RECEPTOR INHIBITOR (R 68070)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643463.

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The effects of R 68070 an oxime-alkane carboxylic acid derivative combining specific thromboxane A2 (TXA2) synthetase inhibition with TXA2/prostaglandin endoperoxide receptor blockade in one molecule, on thrombus formation in a coronary artery following electrically-induced endothelial injury and on its myocardial repercussions were examined in dogs. In an open-chest model in anaesthetized dogs, a stainless steel electrode was inserted into the left anterior descending coronary artery (LAD) distally (+ 1 cm) from an electromagnetic flow probe. ECG and heart rate were derived from limb leads. S
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Hamdi, Hamidreza, Christopher R. Clarkson, and Amin Ghanizadeh. "RTA-Assisted Numerical History-Matching and Co-Optimization of CO2 Storage and HnP Performance for a Near Critical Gas Condensate Shale Well." In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210224-ms.

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Abstract Due to strong non-linearities in the diffusivity equation, numerically-assisted rate-transient analysis (RTA) techniques have been suggested for analysis of multi-phase production data from multi-fractured horizontal wells (MFHWs). However, these methods are based on some limiting assumptions that cannot be generalized for three-phase flow or when relative permeability is unknown. In this study, a new RTA-assisted history-matching technique is proposed to simultaneously match production data and diagnostic plots during the calibration process. In the proposed method, the objective fun
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