Academic literature on the topic 'Linkage (genetics) Chromosome mapping'

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Journal articles on the topic "Linkage (genetics) Chromosome mapping"

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Allen, Sally Lyman, Dawn Zeilinger, and Eduardo Orias. "Mapping Three Classical Isozyme Loci in Tetrahymena: Meiotic Linkage of EstA to the ChxA Linkage Group." Genetics 144, no. 4 (1996): 1489–96. http://dx.doi.org/10.1093/genetics/144.4.1489.

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We demonstrate a reliable method for mapping conventional loci and obtaining meiotic linkage data for the ciliated protozoan Tetrahymena thermophila. By coupling nullisomic deletion mapping with meiotic linkage mapping, loci known to be located on a particular chromosome or chromosome arm can be tested for recombination. This approach has been used to map three isozyme loci, EstA (Esterase A), EstB (Esterase B), and AcpA (Acid Phosphatase A), with respect to the ChxA locus (cycloheximide resistance) and 11 RAPDs (randomly amplified polymorphic DNAs). To assign isozyme loci to chromosomes, clones of inbred strains C3 or C2 were crossed to inbred strain B nullisomics. EstA, EstB and AcpA were mapped to chromosomes 1R, 3L and 3R, respectively. To test EstA and AcpA for linkage to known RAPD loci on their respective chromosomes, a panel of Round II (genomic exclusion) segregants from a B/C3 heterozygote was used. Using the MAPMAKER program, EstA was assigned to the ChxA linkage group on chromosome IR, and a detailed map was constructed that includes 10 RAPDs. AcpA (on 3R), while unlinked to all the RAPDs assigned to chromosome 3 by nullisomic mapping, does show linkage to a RAPD not yet assignable to chromosomes by nullisomic mapping.
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Nelson, J. C., M. E. Sorrells, A. E. Van Deynze, et al. "Molecular mapping of wheat: major genes and rearrangements in homoeologous groups 4, 5, and 7." Genetics 141, no. 2 (1995): 721–31. http://dx.doi.org/10.1093/genetics/141.2.721.

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Abstract A molecular-marker linkage map of hexaploid wheat (Triticum aestivum L. em. Thell) provides a framework for integration with teh classical genetic map and a record of the chromosomal rearrangements involved in the evolution of this crop species. We have constructed restriction fragment length polymorphism (RFLP) maps of the A-, B-, and D-genome chromosomes of homoeologous groups 4, 5, and 7 of wheat using 114 F7 lines from a synthetic X cultivated wheat cross and clones from 10 DNA libraries. Chromosomal breakpoints for known ancestral reciprocal translocations involving these chromosomes and for a known pericentric inversion on chromosome 4A were localized by linkage and aneuploid analysis. Known genes mapped include the major vernalization genes Vrn1 and Vrn3 on chromosome arms 5AL and 5DL, the red-coleoptile gene Rc1 on 7AS, and presumptively the leaf-rust (Puccinia recondita f.sp. tritici) resistance gene Lr34 on 7DS and the kernel-hardness gene Ha on 5DS. RFLP markers previously obtained for powdery-mildew (Blumeria graminis f.sp. tritici) resistance genes Pm2 and Pm1 were localized on chromosome arms 5DS and 7AL.
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Zwick, Michael S., M. Nurul Islam-Faridi, Don G. Czeschin, et al. "Physical Mapping of the liguleless Linkage Group in Sorghum bicolor Using Rice RFLP-Selected Sorghum BACs." Genetics 148, no. 4 (1998): 1983–92. http://dx.doi.org/10.1093/genetics/148.4.1983.

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Abstract Physical mapping of BACs by fluorescent in situ hybridization (FISH) was used to analyze the liguleless (lg-1) linkage group in sorghum and compare it to the conserved region in rice and maize. Six liguleless-associated rice restriction fragment length polymorphism (RFLP) markers were used to select 16 homeologous sorghum BACs, which were in turn used to physically map the liguleless linkage group in sorghum. Results show a basic conservation of the liguleless region in sorghum relative to the linkage map of rice. One marker which is distal in rice is more medial in sorghum, and another marker which is found within the linkage group in rice is on a different chromosome in sorghum. BACs associated with linkage group I hybridize to chromosome It, which was identified by using FISH in a sorghum cytogenetic stock trisomic for chromosome I (denoted It), and a BAC associated with linkage group E hybridized to an unidentified chromosome. Selected BACs, representing RFLP loci, were end-cloned for RFLP mapping, and the relative linkage order of these clones was in full agreement with the physical data. Similarities in locus order and the association of RFLP-selected BAC markers with two different chromosomes were found to exist between the linkage map of the liguleless region in maize and the physical map of the liguleless region in sorghum.
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Farman, M. L., and S. A. Leong. "Genetic and physical mapping of telomeres in the rice blast fungus, Magnaporthe grisea." Genetics 140, no. 2 (1995): 479–92. http://dx.doi.org/10.1093/genetics/140.2.479.

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Abstract Telomeric restriction fragments were genetically mapped to a previously described linkage map of Magnaporthe grisea, using RFLPs identified by a synthetic probe. (TTAGGG)3. Frequent rearrangement of telomeric sequences was observed in progeny isolates creating a potential for misinterpretation of data. Therefore a consensus segregation data set used to minimize mapping errors. TWelve of the 14 telomeres were found to be genetically linked to existing RFLP markers. Second-dimensional electrophoresis of restricted chromosomes confirmed these linkage assignments and revealed the chromosomal location of the two unlinked telomeres. We were thus able to assign all 14 M. grisea telomeres to their respective chromosome ends. The Achilles' cleavage (AC) technique was employed to determine that chromosome 1 markers 11 and CH5-120H were approximately 1.8 Mb and 1.28 Mb, respectively, from their nearest telomeres. RecA-AC was also used to determine that unlinked telomere 6 was approximately 530 kb from marker CH5-176H in strain 2539 and 580 kb in Guy11. These experiments indicated that large portions of some chromosome ends are unrepresented by genetic markers and provided estimates of the relationship of genetic to physical distance in these regions of the genome.
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Meuwissen, Theo H. E., Astrid Karlsen, Sigbjørn Lien, Ingrid Olsaker, and Mike E. Goddard. "Fine Mapping of a Quantitative Trait Locus for Twinning Rate Using Combined Linkage and Linkage Disequilibrium Mapping." Genetics 161, no. 1 (2002): 373–79. http://dx.doi.org/10.1093/genetics/161.1.373.

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Abstract A novel and robust method for the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is proposed. Linkage information refers to recombinations within the marker-genotyped generations and linkage disequilibrium to historical recombinations before genotyping started. The identity-by-descent (IBD) probabilities at the quantitative trait locus (QTL) between first generation haplotypes were obtained from the similarity of the marker alleles surrounding the QTL, whereas IBD probabilities at the QTL between later generation haplotypes were obtained by using the markers to trace the inheritance of the QTL. The variance explained by the QTL is estimated by residual maximum likelihood using the correlation structure defined by the IBD probabilities. Unlinked background genes were accounted for by fitting a polygenic variance component. The method was used to fine map a QTL for twinning rate in cattle, previously mapped on chromosome 5 by linkage analysis. The data consisted of large half-sib families, but the method could also handle more complex pedigrees. The likelihood of the putative QTL was very small along most of the chromosome, except for a sharp likelihood peak in the ninth marker bracket, which positioned the QTL within a region <1 cM in the middle part of bovine chromosome 5. The method was expected to be robust against multiple genes affecting the trait, multiple mutations at the QTL, and relatively low marker density.
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Cheng, Zhukuan, Gernot G. Presting, C. Robin Buell, Rod A. Wing, and Jiming Jiang. "High-Resolution Pachytene Chromosome Mapping of Bacterial Artificial Chromosomes Anchored by Genetic Markers Reveals the Centromere Location and the Distribution of Genetic Recombination Along Chromosome 10 of Rice." Genetics 157, no. 4 (2001): 1749–57. http://dx.doi.org/10.1093/genetics/157.4.1749.

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AbstractLarge-scale physical mapping has been a major challenge for plant geneticists due to the lack of techniques that are widely affordable and can be applied to different species. Here we present a physical map of rice chromosome 10 developed by fluorescence in situ hybridization (FISH) mapping of bacterial artificial chromosome (BAC) clones on meiotic pachytene chromosomes. This physical map is fully integrated with a genetic linkage map of rice chromosome 10 because each BAC clone is anchored by a genetically mapped restriction fragment length polymorphism marker. The pachytene chromosome-based FISH mapping shows a superior resolving power compared to the somatic metaphase chromosome-based methods. The telomere-centromere orientation of DNA clones separated by 40 kb can be resolved on early pachytene chromosomes. Genetic recombination is generally evenly distributed along rice chromosome 10. However, the highly heterochromatic short arm shows a lower recombination frequency than the largely euchromatic long arm. Suppression of recombination was found in the centromeric region, but the affected region is far smaller than those reported in wheat and barley. Our FISH mapping effort also revealed the precise genetic position of the centromere on chromosome 10.
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Tanksley, S. D., M. W. Ganal, J. P. Prince, et al. "High density molecular linkage maps of the tomato and potato genomes." Genetics 132, no. 4 (1992): 1141–60. http://dx.doi.org/10.1093/genetics/132.4.1141.

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Abstract High density molecular linkage maps, comprised of more than 1000 markers with an average spacing between markers of approximately 1.2 cM (ca. 900 kb), have been constructed for the tomato and potato genomes. As the two maps are based on a common set of probes, it was possible to determine, with a high degree of precision, the breakpoints corresponding to 5 chromosomal inversions that differentiate the tomato and potato genomes. All of the inversions appear to have resulted from single breakpoints at or near the centromeres of the affected chromosomes, the result being the inversion of entire chromosome arms. While the crossing over rate among chromosomes appears to be uniformly distributed with respect to chromosome size, there is tremendous heterogeneity of crossing over within chromosomes. Regions of the map corresponding to centromeres and centromeric heterochromatin, and in some instances telomeres, experience up to 10-fold less recombination than other areas of the genome. Overall, 28% of the mapped loci reside in areas of putatively suppressed recombination. This includes loci corresponding to both random, single copy genomic clones and transcribed genes (detected with cDNA probes). The extreme heterogeneity of crossing over within chromosomes has both practical and evolutionary implications. Currently tomato and potato are among the most thoroughly mapped eukaryotic species and the availability of high density molecular linkage maps should facilitate chromosome walking, quantitative trait mapping, marker-assisted breeding and evolutionary studies in these two important and well studied crop species.
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Hanic-Joyce, Pamela J. "MAPPING CDC MUTATIONS IN THE YEAST S. Cerevisiae BY RAD52-MEDIATED CHROMOSOME LOSS." Genetics 110, no. 4 (1985): 591–607. http://dx.doi.org/10.1093/genetics/110.4.591.

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ABSTRACT Using the chromosome loss-mapping method of Schild and Mortimer, I have mapped several new temperature-sensitive mutations that define five CDC genes. Modified procedures were used to facilitate mapping temperature-sensitive mutations in general, and these modifications are discussed. The mutations were assigned to specific chromosomes by chromosome loss procedures, and linkage relationships were determined subsequently by standard tetrad analysis. Four of the mutations define new loci. The fifth mutation, cdc63-1, is shown to be allelic to previously known mutations in the PRT1 gene.
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Sibley, L. D., A. J. LeBlanc, E. R. Pfefferkorn, and J. C. Boothroyd. "Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii." Genetics 132, no. 4 (1992): 1003–15. http://dx.doi.org/10.1093/genetics/132.4.1003.

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Abstract We have constructed a genetic linkage map for the parasitic protozoan, Toxoplasma gondii, using randomly selected low copy number DNA markers that define restriction fragment length polymorphisms (RFLPs). The inheritance patterns of 64 RFLP markers and two phenotypic markers were analyzed among 19 recombinant haploid progeny selected from two parallel genetic crosses between PLK and CEP strains. In these first successful interstrain crosses, these RFLP markers segregated into 11 distinct genetic linkage groups that showed close correlation with physical linkage groups previously defined by molecular karyotype. Separate linkage maps, constructed for each of the 11 chromosomes, indicated recombination frequencies range from approximately 100 to 300 kb per centimorgan. Preliminary linkage assignments were made for the loci regulating sinefungin resistance (snf-1) on chromosome IX and adenine arabinoside (ara-1) on chromosome V by linkage to RFLP markers. Despite random segregation of separate chromosomes, the majority of chromosomes failed to demonstrate internal recombination events and in 3/19 recombinant progeny no intramolecular recombination events were detected. The relatively low rate of intrachromosomal recombination predicts that tight linkage for unknown genes can be established with a relatively small set of markers. This genetic linkage map should prove useful in mapping genes that regulate drug resistance and other biological phenotypes in this important opportunistic pathogen.
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Grivet, Laurent, Angelique D'Hont, Daniele Roques, Philippe Feldmann, Claire Lanaud, and Jean Christophe Glaszmann. "RFLP Mapping in Cultivated Sugarcane (Saccharum spp.): Genome Organization in a Highly Polyploid and Aneuploid Interspecific Hybrid." Genetics 142, no. 3 (1996): 987–1000. http://dx.doi.org/10.1093/genetics/142.3.987.

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Abstract Sugarcane cultivars are polyploid, aneuploid, interspecific hybrids between the domesticated species Saccharum officinarum and the wild relative S. spontaneum. Cultivar chromosome numbers range from 100 to 130 with ~10% contributed by S. spontaneum. We have undertaken a mapping study on the progeny of a selfed cultivar, R570, to analyze this complex genome structure. A set of 128 restriction fragment length polymorphism probes and one isozyme was used. Four hundred and eight markers were placed onto 96 cosegregation groups, based on linkages in coupling only. These groups could tentatively be assembled into 10 basic linkage groups on the basis of common probes. Origin of markers was investigated for 61 probes and the isozyme, leading to the identification of 80 S. officinarum and 66 S. spontaneum derived markers, respectively. Their distribution in cosegregation groups showed better map coverage for the S. spontaneum than for the S. officinnrum genome fraction and occasional recombination between the two genomes. The study of repulsions between markers suggested the prevalence of random pairing between chromosomes, typical of autopolyploids. However, cases of preferential pairing between S. spontaneum chromosomes were also detected. A tentative Saccharum map was constructed by pooling linkage information for each linkage group.
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Dissertations / Theses on the topic "Linkage (genetics) Chromosome mapping"

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Stephens, Sarah H. "Fine mapping of the chromosome 15q13-14 schizophrenia linkage region /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 112-128). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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Fratini, Antonio. "Fragile sites on human chromosome 16 : a linkage analysis study /." Title page, table of contents and summary only, 1988. http://web4.library.adelaide.edu.au/theses/09PH/09phf844.pdf.

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Apostolou, Sinoula. "Physical mapping of human chromosome 16." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09pha645.pdf.

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Wahlberg, Per. "Chicken Genomics - Linkage and QTL mapping." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9502.

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Åkesson, Eva. "Genetic mapping and association analysis in multiple sclerosis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-174-1/.

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Mulley, John Charles. "Genetic marker studies in humans /." Title page, contents and summary only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phm958.pdf.

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Tell, Désirée von. "Welander distal myopathy : gene mapping and analysis of candidate genes /." Stockholm, 2004. http://diss.kib.ki.se/2003/91-7349-764-9.

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Modin, Helena. "Multiple sclerosis : linkage analysis and DNA variation in a complex trait /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-792-4/.

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Djureinovic, Tatjana. "Investigation of genetic factors involved in colorectal cancer predisposition /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-864-9/.

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Li, Fang-Yuan. "Genetic study of autosomal dominant progressive external ophthalmoplegia and familial myasthenia gravis : linkage analysis, candidate gene cloning and mutation detection /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4695-7/.

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Books on the topic "Linkage (genetics) Chromosome mapping"

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Neale, Benjamin M. Statistical genetics: Gene mapping through linkage and association. Taylor & Francis Group, 2008.

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J, Balding D., Bishop M, and Cannings C. 1942-, eds. Handbook of statistical genetics. 2nd ed. John Wiley & Sons, 2003.

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J, Balding D., Bishop M, and Cannings C. 1942-, eds. Handbook of statistical genetics. Wiley, 2001.

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Helsinki), International Workshop on Human Gene Mapping (8th 1985 University of. Human gene mapping 8. Karger, 1985.

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Miller, James R. X-linked traits: A catalog of loci in nonhuman mammals. Cambridge University Press, 1990.

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A, McKusick Victor. The morbid anatomy of the human genome: A review of gene mapping in clinical medicine. Howard Hughes Medical Institute (6701 Rockledge Dr., Bethesda 20817), 1988.

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Postel-Vinay, Olivier. La revanche du chromosome X: Enquête sur les origines et le devenir du féminin. JC Lattès, 2007.

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Jean, Frézal, Klinger Harold P. 1929-, and March of Dimes Birth Defects Foundation., eds. Human gene mapping, 9: Paris Conference (1987), Ninth International Workshop on Human Gene Mapping at the University of Paris, Faculté de Médecine, France, September 6-11, 1987. Karger, 1987.

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National Research Council (U.S.). Committee on Mapping and Sequencing the Human Genome. Mapping and sequencing the human genome: Committee on Mapping and Sequencing the Human Genome, Board on Basic Biology, Commission on Life Sciences, National Research Council. National Academy Press, 1988.

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RNA mapping: Methods and protocols. Humana Press, 2014.

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Book chapters on the topic "Linkage (genetics) Chromosome mapping"

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Blank, R. D., G. R. Campbell, M. Pollak, and P. D’Eustachio. "Bayesian Multilocus Linkage Mapping." In Genetics of Immunological Diseases. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-50059-6_4.

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Kowles, Richard. "Linkage, Recombination, and Mapping." In Solving Problems in Genetics. Springer New York, 2001. http://dx.doi.org/10.1007/978-1-4613-0205-6_4.

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Kulwal, Pawan L. "Trait Mapping Approaches Through Linkage Mapping in Plants." In Plant Genetics and Molecular Biology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/10_2017_49.

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Ott, J., C. Aston, M. Baur, et al. "Detection and Estimation of Linkage, Especially Multipoint Mapping." In Human Genetics. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71635-5_20.

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Lalouel, Jean-Marc. "Linkage analysis in human genetics." In Plant Genomes: Methods for Genetic and Physical Mapping. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2442-3_8.

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Wahlström, Jan, Rolf Axelsson, and Tonnie Johannesson. "Chromosome Aberrations as Tools for Gene Mapping." In Genetics of Neuropsychiatric Diseases. Macmillan Education UK, 1989. http://dx.doi.org/10.1007/978-1-349-10729-2_6.

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Sorrells, Mark E., and Jianming Yu. "Linkage Disequilibrium and Association Mapping in the Triticeae." In Genetics and Genomics of the Triticeae. Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-77489-3_22.

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Van Broeckhoven, C., W. Van Hul, H. Backhovens, et al. "Genetic Linkage Analysis in Two Large Belgian Alzheimer Families with Chromosome 21 DNA Markers." In Genetics and Alzheimer’s Disease. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73647-6_12.

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Sarma, R. N., B. S. Gill, T. Sasaki, et al. "Comparative Mapping of the Wheat Chromosome 5a Vrn-A1 Region with Rice and its Relationship to QTL for Flowering Time." In Stadler Genetics Symposia Series. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4235-3_22.

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"Linkage and chromosome mapping." In Genetics and Evolution of the Domestic Fowl. Cambridge University Press, 1991. http://dx.doi.org/10.1017/cbo9780511525780.006.

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Conference papers on the topic "Linkage (genetics) Chromosome mapping"

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Giannelli, B. F. "MOLECULAR GENETICS OF HAEMOPHILIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643981.

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Haemophilia B, an X-linked recessive disease with an incidence of 1/30,000 newborn males, is due to defects in the gene for coagulation factor IX, which is on the long am of the X chromosome at band Xq27.1. This gene consists of approximately 34 Kb and contains 8 exons which specify a mRtfc of 2803 residues coding for a protein of 415 aa preceded by a prepro signal peptide of 46 aa. Coripanson of the functional domains of the factor IX protein with the exon structure of the gene supports the exon/protein domain hypothesis of gene evolution. The factor IX gene seems to be formed by a number of functionally and evolutionally independent modules. The signal peptide and the gla (γcarboxy-glutamic) region encoded in the first three exons are homologous to those of factor X, protein C and prothrombin. Thevfourth and fifth exons which code for the connecting peptide are homologous to one another and to the epidermal growth factor, a module that has been used in the construction of a great variety of proteins including different members of the coagulation and fibrinolytic pathways. The sixth exon encodes the activation peptide region, while the catalytic region of factor IX is coded by the seventh and eighth exon. This is at variance with other serine protease genes that have different exons for the segments containing the cardinal ami no-acids of the active centre (histidine, aspartic acid and serine).Natural selection acts against detrimental mutations of the factor IX gene and at each generation a proportion of haemophilia B genes is eliminated, as a significant number of patients does not reproduce. There appears to be no selective advantage to the heterozygote and therefore haemophilia B is maintained in the population by new mutations. Consequently, a significant proportion of patients should be born to non-carrier mothers, and unrelated patients should carry different gene defects, as recently verified by detailed analysis of individual haemophilia B genes.The defects of factor IX described so far comprise both point mutations and gene deletions. The latter affect either part or the whole of the gene and are often associated with the development of antibodies against therapeutically adninistered factor IX (the inhibitor complication). Since gene deletions may result in the complete absenceof factor IX synthesis or in the production of an extremely abnormal product, it has been suggested that mutationspreventing the synthesis of a factor IX gene product capable of inducing immune tolerance to normal factor IX is important in predisposing to the inhibitor complication.Among the point mutations described so far, those affecting the signal peptide are of particular interest. Substitutions of the arginine at positions -4 and -1 cause failure of propeptide cleavage. Thus they indicate that the propeptide consists of 18 aa an(lthat lts excision is necessary for factor IX function. It appears also that the propeptide contains a signal for γcarboxylation which has been conserved during the evolution of different γcarboxylated proteins.In spite of coagulant treatment, haemophilia B is a serious disease and one for which genetic counselling is required. Paramount for this is the detection of carriers and the diagnosis ofaffected male fetuses. DNA probes derived from the cloned factor IX gene have been used for this purpose. Carrier and first or second trimester prenatal diagnoses have been done using factors IX gene markers to follow the transmission of haemophilia B genes. Six sequence variations causing restriction fragment length polymorphisms (RFLP) in the factor IX gene have been detected and used as markers for such indirect diagnoses The efficiency of the above markers is reduced by linkage disequilibrium but, nevertheless, they offer definite carrier and nremtal diagnoses in 75-80% of the relatives of familial cases of haemophilia B.The indirect detection of gene defects is of modest help in the counselling of individuals from the families of isolated patients, but new methods for the direct detection of gene mutations promise better results in such families and also the attainment of % diagnostic success in relatives of familial cases.Finally the successful expression of recombinant factor IX genes in tissue culture and transgenic mammals raises hopes of therapeutic advances.
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Reports on the topic "Linkage (genetics) Chromosome mapping"

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Antonarakis, S. E. Human chromosome 21: Linkage mapping and cloning in yeast artificial chromosomes. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/6278130.

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Foulkes, William D. Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populationin Quebec and Switzerland. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada426100.

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Foulkee, William D. Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443199.

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Foulkes, William D. Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada405914.

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Foulkes, William D. Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada415657.

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