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Journal articles on the topic 'Lipid-based formulation'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Santosh, Payghan, Vaishali Kate, Sanjeevani Desai, Bhise Sandesh, Pradip Deshmukh, and Atul Deshmukh. "Composition of Lipid Based Nanoemulsion for Oral Delivery of Orlistat." Middle East Research Journal of Pharmaceutical Sciences 3, no. 06 (2023): 70–81. http://dx.doi.org/10.36348/merjps.2023.v03i06.001.

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Aim: The present work focused on to formulate, evaluate and optimize lipid based nanoemulsion of orlistat to enhance drug release. Materials and Methods: Nanoemulsion was prepared using Olive oil, Tween 80, and Distilled water as components. Lipid based nanoemulsion was evaluated for its pH, Rheology study, zeta potential, conductivity, particle size analysis, transmission electron microscopy (TEM) and stability. Central composite design was utilized for the optimization purpose. Formulation variables such as the concentration of Oil (ml) (X1) and Water (ml) (X2) were investigated for their ef

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Kotta, Sabna, Navneet Sharma, Prateek Raturi, Mohd Aleem, and Rakesh Kumar Sharma. "Exploring Novel Strategies for Lipid-Based Drug Delivery." Journal of Nanotoxicology and Nanomedicine 3, no. 1 (2018): 1–22. http://dx.doi.org/10.4018/jnn.2018010101.

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Currently, the concept of lipid-based drug delivery systems has gained much interest because of their capability to deliver drugs which dissolve sparingly in water or insoluble in nature. Several methods of lipid-based drug delivery exist, and each method has its own advantages as well as limitations. The primary objective of the formulation development is to improve the bioavailability of the drug. The nano-sized lipid-based drug delivery systems have enough potential to do so. This article addresses the various barriers to the transportation of drugs through certain routes and also the commo

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Efendy Goon, Danial, Siti Hamimah Sheikh Abdul Kadir, Normala Ab Latip, Sharaniza Ab. Rahim, and Musalmah Mazlan. "Palm Oil in Lipid-Based Formulations and Drug Delivery Systems." Biomolecules 9, no. 2 (2019): 64. http://dx.doi.org/10.3390/biom9020064.

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Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. Palm oil and palm kernel oil contain long-chain and medium-chain triglycerides, respectively, including phytonutrients such as tocotrienol, tocopherol and carotenes. The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. The utilisation of palm oil as part of the drug delivery system seemed to improve the bioavailability a

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Shrestha, Hina, Rajni Bala, and Sandeep Arora. "Lipid-Based Drug Delivery Systems." Journal of Pharmaceutics 2014 (May 19, 2014): 1–10. http://dx.doi.org/10.1155/2014/801820.

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The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations

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Boyd, Ben J., and Andrew J. Clulow. "The influence of lipid digestion on the fate of orally administered drug delivery vehicles." Biochemical Society Transactions 49, no. 4 (2021): 1749–61. http://dx.doi.org/10.1042/bst20210168.

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This review will focus on orally administered lipid-based drug delivery vehicles and specifically the influence of lipid digestion on the structure of the carrier lipids and their entrained drug cargoes. Digestion of the formulation lipids, which are typically apolar triglycerides, generates amphiphilic monoglycerides and fatty acids that can self-assemble into a diverse array of liquid crystalline structures. Tracking the dynamic changes in self-assembly of the lipid digestion products during digestion has recently been made possible using synchrotron-based small angle X-ray scattering. The i

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Nicolai, Marisa, Vanessa Amaral, Cátia Antunes, Duangratana Shuwisitkul, and Joana Portugal Mota. "Lipid-Based Implants: Impact of Formulation Parameters." Advanced Materials Research 1060 (December 2014): 87–90. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.87.

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Lipid implants have been attracting attention in recent years. However, to better understand these systems, more fundamental studies are required. The objective of this work was to evaluate the effect of some formulation parameters, namely lipid and drug type, implant shape/surface area and lipid blend ratio, on drug release rate. The developed implants were cylindrical or spherical in shape with an even surface. Caffeine release from glycerol-trimyristate implant was very fast when compared with glycerol-tristerate matrix. The latter allowed a 4 month controlled release in contrast with glyce

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Porter, Christopher J. H., Hywel D. Williams, and Natalie L. Trevaskis. "Recent Advances in Lipid-Based Formulation Technology." Pharmaceutical Research 30, no. 12 (2013): 2971–75. http://dx.doi.org/10.1007/s11095-013-1229-7.

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8

Chintamani Panda, Sachinkumar Prabhubhai Chauhan, and Krishnan Balamurugan. "Formulation and In Vitro Characterization of Raloxifene Nanostructured Lipid Carriers For Oral Delivery With Full Factorial Design-Based Studies Using Quality By Design (QbD) Approach." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6417–27. http://dx.doi.org/10.26452/ijrps.v11i4.3434.

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The main aim of the present study is to improve the dissolution rate of Raloxifene Hydrochloride by formulating nanostructured lipid carriers (NLC) using Quality by Design (QbD) approach. The formulations of NLC-RH were prepared by the ultrasonication method using stearic acid as solid lipid, medium-chain triglyceride as the liquid lipid and polysorbate 80 as the surface-active agent. Two most critical quality attributes (CQAs) for NLC-RH were particle size and entrapment efficiency. The other attributes of medium influence identified includes dissolution rate, zeta potential and particle size

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Song, Jae Geun, Hye-Mi Noh, Sang Hoon Lee, and Hyo-Kyung Han. "Lipid/Clay-Based Solid Dispersion Formulation for Improving the Oral Bioavailability of Curcumin." Pharmaceutics 14, no. 11 (2022): 2269. http://dx.doi.org/10.3390/pharmaceutics14112269.

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This study was conducted to develop a lipid/clay-based solid dispersion (LSD) formulation to enhance the dissolution and oral bioavailability of poorly soluble curcumin. Krill oil and aminoclay were used as a lipid and a stabilizer, respectively, and LSD formulations of curcumin were prepared by an antisolvent precipitation method combined with freeze-drying process. Based on the dissolution profiles, the optimal composition of LSD was determined at the weight ratio of curcumin: krill oil: aminoclay of 1:5:5 in the presence of 0.5% of D-α-tocopherol polyethylene glycol succinate. The structura

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10

AGBO, CHINAZOM PRECIOUS, MARIA IFEYINWA NGWU, UGOMMA ANYAJI, et al. "PREPARATION OF LIPID-BASED FORMULATIONS USING LOCAL BEESWAX SOURCED FROM HONEYCOMBS." African Journal of Pharmaceutical Research and Development 16, no. 2 (2024): 76–87. http://dx.doi.org/10.59493/ajopred/2024.2.8.

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Solid lipids used in formulation of novel drug delivery systems in most developing countries are sourced from abroad and are quite expensive. Wax from honeycombs is readily available, and is even disposed as waste, but can be utilized as a solid lipid for the formulation of different lipid-based drug delivery systems. This study aims to formulate and compare the features of the solid lipid nanoparticle (SLNs) and nanostructured lipid carrier (NLCs) delivery systems of quinine hydrochloride made with local beeswax (that is beeswax from locally sources honeycomb waste) and other solid lipids sou

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Kim, Min-Hwan, Yae-Eun Jeon, Soobeen Kang, et al. "Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol." Pharmaceutics 12, no. 9 (2020): 845. http://dx.doi.org/10.3390/pharmaceutics12090845.

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Orobol is one of the major soy isoflavones, and has been reported to have various pharmacological activities, including an anti-skin-aging effect. However, since it has low solubility in water and physicochemical instability, the formulation of orobol for delivery into the dermal layer of the skin could be challenging. The objective of this study was to prepare lipid nanoparticles formulations of orobol to enhance its stability as well as its deposition into the skin. Formulations of orobol-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were characterized in t

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12

Chavda, Vivek P., Hetvi K. Solanki, Dixa A. Vaghela, Karishma Prajapati, and Lalitkumar K. Vora. "Nanotechnology-Based Face Masks: Transforming the Cosmetics Landscape." Micro 5, no. 1 (2025): 11. https://doi.org/10.3390/micro5010011.

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The cosmetic market is constantly evolving and ever-changing, particularly with the introduction and incorporation of nanotechnology-based processes into cosmetics for the production of unique formulations with both aesthetic and therapeutic benefits. There is no doubt that nanotechnology is an emerging technology for cosmetic formulations. Among the numerous cosmetic items, incorporating nanomaterials has provided a greater scope and is commonly utilized in facial masks, hair products, antiaging creams, sunscreen creams, and lipsticks. In cosmetics, nanosized materials, including lipid crysta

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13

NARENDER, BOGGULA, BAKSHI VASUDHA, and PEDDAPALLI HIMABINDU. "An overview of lipid based vesicular systems: stability and regulatory considerations." GSC Biological and Pharmaceutical Sciences 21, no. 3 (2022): 053–61. https://doi.org/10.5281/zenodo.7653074.

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Lipid based drug delivery systems are used to encapsulate the active substance within or interior space of the lipid bilayer. The lipid-based drug products are designed to improve the stability in-vivo and pharmacokinetics behavior of active substances. However, understanding of the factors that affect the stability is critical for rationale development of lipid based drug delivery systems with desired pharmacokinetics and bio-distribution. Lyophilization is one primary approach to improve the stability of lipid based systems. The article presents an overview of the characteristics of the lipi

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14

Thomas, Nicky, René Holm, Thomas Rades, and Anette Müllertz. "Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development." AAPS Journal 14, no. 4 (2012): 860–71. http://dx.doi.org/10.1208/s12248-012-9398-6.

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15

Tay, Erin, Tri-Hung Nguyen, Leigh Ford, et al. "Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure." Pharmaceutics 12, no. 1 (2019): 17. http://dx.doi.org/10.3390/pharmaceutics12010017.

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Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as low melting, lipophilic salts or ionic liquids (ILs) provides one means to enhance drug solubility in LBFs. However, whether different ILs benefit from formulation in different LBFs is largely unknown. In the current studies, lumefantrine was isolated as a number of different lipophilic salt/ionic liquid forms and performance was assessed after form

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Pamornpathomkul, Boonnada, Worranan Rangsimawong, Theerasak Rojanarata, Praneet Opanasopit, Chuleerath Chaiyodsilp, and Tanasait Ngawhirunpat. "Lipid-based nanocarriers to enhance skin permeation and antioxidant activity of Centella asiatica extract." MATEC Web of Conferences 192 (2018): 01016. http://dx.doi.org/10.1051/matecconf/201819201016.

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The purpose of this study was to evaluate the use of different formulations, including solution, gel, liposome and niosome for in vitro skin permeation and antioxidant activity of Centella asiatica (CA) extract. The liposomes and niosomes loaded with CA were characterized to observe the physicochemical properties i.e., particle size, zeta potential, percentage of entrapment efficiency (%EE) and percentage of loading efficiency (%LE). In vitro skin permeation studies revealed that liposome formulations had a superior enhancing effect on skin permeation compared to niosome, gel and solution form

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17

Mounika, Nandru* Madhu Gudipati S.S. Manikiran and Ramarao Nadendla. "LIPID BASED DRUG DELIVERY SYSTEM – A REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 5834–44. https://doi.org/10.5281/zenodo.2598606.

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<em>Lipid-based drug delivery systems (LBDDS) have gained significant attention in recent times, owing to their ability to overcome the challenges limiting the oral delivery of poorly water-soluble drugs. Despite the successful commercialization of several LBDDS products over the years, a large discrepancy exists between the number of poorly water-soluble drugs displaying optimal in-vivo performances and the application of LBDDS to mitigate their various delivery challenges. The formation of drugs carried out with the principle objective of enhancing their bioavailability. Poorly water-soluble

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18

Haranath, Chinthaginjala. "Recent advances in lipid based nanovesicles for transdermal drug delivery." Journal of medical pharmaceutical and allied sciences 11, no. 6 (2022): 5375–81. http://dx.doi.org/10.55522/jmpas.v11i6.4273.

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Lipid based nanovesicles are the formulations which are used for the delivery of hydrophilic, hydrophobic and amphiphilic drugs or compounds. They are very helpful for the drugs which are hydrophilic and irritant drugs that can be encapsulated and delivered to the target site. They are very advantageous over conventional formulations. Lipid based nanovesicular systems will efficaciously help the drugs addressing the issues of solubility and penetration thereby promotes bioavailability. Now a days lipid based nanovesicles for transdermal delivery of drug has become very useful especially for hy

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19

Bahadori, Fatemeh, Gülaçtı Topçu, Mehmet S. Eroğlu, and Hayat Önyüksel. "A New Lipid-Based Nano Formulation of Vinorelbine." AAPS PharmSciTech 15, no. 5 (2014): 1138–48. http://dx.doi.org/10.1208/s12249-014-0146-3.

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20

Patel, Vivek, Rohan Lalani, Denish Bardoliwala, Saikat Ghosh, and Ambikanandan Misra. "Lipid-Based Oral Formulation Strategies for Lipophilic Drugs." AAPS PharmSciTech 19, no. 8 (2018): 3609–30. http://dx.doi.org/10.1208/s12249-018-1188-8.

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21

Amin Mir M, Muhammad Waqar Ashraf, and Maythem Mahmud. "Formulation Design and Evaluation of Solid Lipid Micro-particles of Curcumin for the Treatment of Alzheimer’s disease." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6739–47. http://dx.doi.org/10.26452/ijrps.v11i4.3610.

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Solid lipid microparticles reach the site of its action in a controlled rate and do show controlled release for a better therapeutic result. A good drug carrying and release system involve a controlled drug delivery that improves bioavailability, to enrich stability and to minimise the toxic effects followed with a targeted drug at the site of its action. The solid lipid microparticles of curcumin were prepared in a view to achieving high permeability of curcumin in the brain through blood-brain-barrier. The lipid microsphere solids were prepared by hot melts microencapsulation technique to fo

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Rajshri.R.Dusane, Yogeeta.S.Agrawal Sonia.M.Goyal Kalyani.A.Chaudhari. "A REVIEW ARTICLE ON NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR DRUG DELIVERY AND TARGETING SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9568–77. https://doi.org/10.5281/zenodo.2819849.

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<em>During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles’ formulation and increased knowledge of the underlying mechanisms of transport of NLC via different routes of administration. This review article aims to give an overview on the current state of the art of nanostructured lipid carriers as controlled drug delivery systems for future clinics through novel NLC appl

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Saraswat, Aishwarya, Alireza Nomani, Lin-Kin Yong, et al. "A Polysorbate-Based Lipid Nanoparticle Vaccine Formulation Induces In Vivo Immune Response Against SARS-CoV-2." Pharmaceutics 17, no. 4 (2025): 441. https://doi.org/10.3390/pharmaceutics17040441.

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Background: Lipid nanoparticles (LNPs) have proven effective in delivering RNA-based modalities. Rapid approval of the COVID-19 vaccines highlights the promise of LNPs as a delivery platform for nucleic acid-based therapies and vaccines. Nevertheless, improved LNP designs are needed to advance next-generation vaccines and other gene therapies toward greater clinical success. Lipid components and LNP formulation excipients play a central role in biodistribution, immunogenicity, and stability. Therefore, it is important to understand, identify, and assess the appropriate lipid components for dev

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S., Divakar* K. Shanthini. "Formulation and Evaluation of Trigonella foenum-graecum l. loaded Nanostructured Lipid Carrier based Buccal Patch by using Natural oil." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 706–24. https://doi.org/10.5281/zenodo.12730715.

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Nano structured lipid carrier(NLC) are the 2nd generation lipid Nanoparticle formulated using <em>Trigonella foenum-graecum l.</em> loaded into NLC as Buccal patch as a dosage form to enhance the efficiency of the drug for the treatment of Hyperglycemia. Using Stearic acid and Soybean oil as lipid phase and Span 60 with water as aqueous phase mixed together completely using magnetic stirrer to form a emulsion. Formed NLC emulsion loaded into the buccal patch as a dosage form. Among the formulations N1 to N8, formulation N4 consider as the best with the drug release of 97%. Formulation N4 incor

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Rahnfeld, Lisa, and Paola Luciani. "Injectable Lipid-Based Depot Formulations: Where Do We Stand?" Pharmaceutics 12, no. 6 (2020): 567. http://dx.doi.org/10.3390/pharmaceutics12060567.

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The remarkable number of new molecular entities approved per year as parenteral drugs, such as biologics and complex active pharmaceutical ingredients, calls for innovative and tunable drug delivery systems. Besides making these classes of drugs available in the body, injectable depot formulations offer the unique advantage in the parenteral world of reducing the number of required injections, thus increasing effectiveness as well as patient compliance. To date, a plethora of excipients has been proposed to formulate depot systems, and among those, lipids stand out due to their unique biocompa

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Irfan, Muhammad, Mir Azam Khan, Aziz Ur Rehman, and Faiza Naureen. "Optimization of Lipid-Based Ketoconazole Nanoformulations Through Stirring Techniques and Ingredient Quantity Adjustments." Pharmaceutical Communications 3, no. 01 (2024): 35–44. https://doi.org/10.55627/pharma.003.001.0886.

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The Biopharmaceutical Classification System (BCS) classifies drugs on the basis of solubility and permeability. Ketoconazole belongs to class II drugs of the Biopharmaceutical Classification System (BCS) which are characterized by high permeability but low solubility issues. The current research work aimed to formulate optimized nano-formulation for ketoconazole by altering stirring time, speed, and ingredient ratios. In this study, a stirring speed minimum of 600 rpm and a maximum of 1200 rpm was used. The minimum stirring time of 7 minutes and a maximum of 30 minutes was noted. Olive oil was

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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have b

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Wurms, Kirstin, and Annette Ah Chee. "Product formulation is crucial to the success of lipid-based bio-fungicides." New Zealand Plant Protection 71 (July 29, 2018): 272–84. http://dx.doi.org/10.30843/nzpp.2018.71.124.

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Powdery mildew is a major cause of damage to squash plants. Anhydrous milk fat (AMF) or soybean oil (SBO) may be effective at treating this disease but these active ingredients must be mixed with an emulsifier to enable even distribution and suspension of fat globules, and an antioxidant to prevent rancidity. The overall formulation may affect disease control efficacy, leaf health and product stability. The effect of different emulsifiers and antioxidants on emulsion stability, odour and shelf-life of AMF and SBO bio-fungicides was tested in laboratory assays, and on powdery mildew disease con

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Parks, Colby L., William Tucker, Corey A. Amlong, Sandro Mecozzi, and Robert A. Pearce. "Lipid-free Fluoropolymer-based Propofol Emulsions and Lipid Reversal of Propofol Anesthesia in Rats." Anesthesiology 124, no. 6 (2016): 1328–37. http://dx.doi.org/10.1097/aln.0000000000001080.

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Abstract Background Propofol, as a lipid-based emulsion, is effective at inducing anesthesia. It does, however, suffer from several drawbacks, including microbial growth, hyperlipidemia, and pain on injection. In this study, the authors examined the ability of four lipid-free propofol nanoemulsions to induce anesthesia in rats and tested whether a subsequent lipid bolus would accelerate emergence from anesthesia. Methods The authors administered five formulations of propofol intravenously to six rats, delivering five different doses five times each, in a repeated-measures randomized crossover

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NARENDER BOGGULA, VASUDHA BAKSHI, and HIMABINDU PEDDAPALLI. "An overview of lipid based vesicular systems: stability and regulatory considerations." GSC Biological and Pharmaceutical Sciences 21, no. 3 (2022): 053–61. http://dx.doi.org/10.30574/gscbps.2022.21.3.0458.

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Lipid based drug delivery systems are used to encapsulate the active substance within or interior space of the lipid bilayer. The lipid-based drug products are designed to improve the stability in-vivo and pharmacokinetics behavior of active substances. However, understanding of the factors that affect the stability is critical for rationale development of lipid based drug delivery systems with desired pharmacokinetics and bio-distribution. Lyophilization is one primary approach to improve the stability of lipid based systems. The article presents an overview of the characteristics of the lipi

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Lokhande, Karan K., Pranali P. Malusare, Dhanashree P. Sanap, and Kisan R. Jadhav. "FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE." INDIAN DRUGS 61, no. 07 (2024): 49–58. http://dx.doi.org/10.53879/id.61.07.14547.

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The objective of this investigation was to formulate an ideal nanostructured lipid carrier (NLC) for glibenclamide in oral capsules. Employing factorial design, the NLC formulation was achieved through high-pressure homogenization using Design-Expert® software, optimized using a 32 -factor experimental design and response surface analysis. Comprehensive analyses were conducted to characterize NLCs and determine the optimal formulation. Rigorous evaluations, including drug content, in vitro diffusion and stability studies, were performed. Safety assessments, efficacy studies and optimization le

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Bala, Tripura Sundari I., and C. V. S. Subramanyam. "Formulation and Evaluation of Lipid Based Nanoparticles of Etravirine." Journal of Drug Delivery and Therapeutics 14, no. 1 (2024): 79–90. http://dx.doi.org/10.22270/jddt.v14i1.6373.

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Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases like HIV/AIDS. Etravirine is one of the key components of highly active antiretroviral therapy used for the treatment of HIV-1 infections. The aim of the present study was to formulate and evaluate nanostructured lipid carriers of etravirine, intended for targeted delivery to macrophages, using solvent emulsification - evaporation technique. Estimates of drug solubility were employed for selection of solid lipids, liquid lipids and stabilizers for the preparation of NLCs. Design of experim

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Ah Chee, Annette, Maureen George, Maryam Alavi, and Kirstin Wurms. "Lipid-based bio-fungicides for control of powdery mildew in cucurbits." New Zealand Plant Protection 71 (July 29, 2018): 262–71. http://dx.doi.org/10.30843/nzpp.2018.71.123.

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Powdery mildew (PM) infection of cucurbits is a major problem facing commercial New Zealand growers. Resistance to demethylation inhibitor fungicides is widespread so, there is a demand for new-generation bio-fungicides that can provide durable control alternatives in both conventional and organic systems. A wide range of milk products, plant and animal fats/oils, and natural plant elicitors were tested for their ability to control PM on squash and zucchini plants in a series of four glasshouse trials. The most promising product tested was anhydrous milk fat (AMF), in formulation with an emuls

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Noor, Norhayati Mohamed, Sana Umar, Azila Abdul-Aziz, Khalid Sheikh, and Satyanarayana Somavarapu. "Engineered Dutasteride-Lipid Based Nanoparticle (DST-LNP) System Using Oleic and Stearic Acid for Topical Delivery." Bioengineering 9, no. 1 (2022): 11. http://dx.doi.org/10.3390/bioengineering9010011.

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Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations. A lipid-based nanoparticle system composed of stearic and oleic acid (solid and liquid lipid) was used to deliver dutasteride (DST) for topical application. Two compositions, with oleic acid (Formulation A) and without (Formulation B), were compared to analyse the role of oleic acid as a potential active ingredient in addition to DS

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Kirmizitaş, Fatma Ceren, Hanife Sevgi Varli, Murat Demirbilek, and Nelisa Türkoğlu. "Effect of Surfactant on controlling the Size of Octadecylamine-based Solid Lipid Nanoparticles and Toxicity." Research Journal of Biotechnology 18, no. 7 (2023): 131–41. http://dx.doi.org/10.25303/1807rjbt1310141.

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Surfactants play a major role in solid lipid nanoparticles’ (SLNs) composition and properties, especially in terms of particle size and zeta potential. Not only the type of the surfactants but also their amounts and chemical compatibility with the lipid core within the formulation cause good changes. In this study, our goal was to determine the effect of tween 80 (a non-ionic surfactant) on octadecylamine (cationic lipid)-based SLN formulation and its influence on SLNs properties. Also, we examined the effect of sonication and filtration as mechanical forces on the particle size, zeta potentia

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Madhuri, Desavathu* Azad Bharti Princee Verma. "Lipid Based Drug Delivery System : The Best Way For Better Absorption." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 208–29. https://doi.org/10.5281/zenodo.11482174.

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Above half of the new chemical entities are lipophilic in nature. The major problem in the oral formulation of BCS Class ΙΙ and ΙV drugs is lower and inconsistent bioavailability, which is primarily resulted from poor water solubility and slow dissolution rate. It may lead to high intra and inter-subject variability and therapeutic failure. Lipid based formulations has gained more popularity with oils and the possess greater bioavailability because of their ability to  bypass the passage into hepatic portal vein and evade hepatic degradation. Self-emulsifying drug delivery

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Holmbäck, Jan, Vibhu Rinwa, Tobias Halthur, Puneet Rinwa, Anders Carlsson, and Bengt Herslöf. "AKVANO®: A Novel Lipid Formulation System for Topical Drug Delivery—In Vitro Studies." Pharmaceutics 14, no. 4 (2022): 794. http://dx.doi.org/10.3390/pharmaceutics14040794.

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A novel formulation technology called AKVANO® has been developed with the aim to provide a tuneable and versatile drug delivery system for topical administration. The vehicle is based on a water-free lipid formulation where selected lipids, mainly phospholipids rich in phosphatidylcholine, are dissolved in a volatile solvent, such as ethanol. With the aim of describing the basic properties of the system, the following physicochemical methods were used: viscometry, dynamic light scattering, NMR diffusometry, and atomic force microscopy. AKVANO formulations are non-viscous, with virtually no or

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Raj, Rakesh, Pooja Mongia Raj, and Alpana Ram. "Lipid based noninvasive vesicular formulation of cytarabine: Nanodeformable liposomes." European Journal of Pharmaceutical Sciences 88 (June 2016): 83–90. http://dx.doi.org/10.1016/j.ejps.2016.04.002.

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Kakkar, Shilpa, Sankunny Mohan Karuppayil, Jayant S. Raut, et al. "Lipid-polyethylene glycol based nano-ocular formulation of ketoconazole." International Journal of Pharmaceutics 495, no. 1 (2015): 276–89. http://dx.doi.org/10.1016/j.ijpharm.2015.08.088.

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Sinhal, Amit, and Rajendra Wagh. "Formulation and Assessment of Lipid-based Nanoformulation of Luliconazole." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 429–41. http://dx.doi.org/10.25258/ijddt.14.1.62.

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The luliconazole preformulation study aimed to determine the best way to administer medicine using SNEDDS. The plain white powder, luciconazole, showed a number of different crystal structures and was very soluble in isopropyl myristate and oleic acid, as confirmed through partition coefficients in n-octanol. With a robust linear standard curve at 295 nm, UV spectroscopy verified its dependability for analysis. Luliconazole and the necessary excipients for SNEDDS formulation were found to be compatible according to fourier-transform infrared spectroscopy (FTIR) spectra. Using a 32-factorial de

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Sinhal, Amit, and Rajendra Wagh. "Formulation and Evaluation of Lipid-based Nanoformulation of Itraconazole." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 417–28. http://dx.doi.org/10.25258/ijddt.14.1.61.

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The powdered form of itraconazole is white, flavorless, and stable, but it dissolves slowly in water. In comparison to palmitic acid, stearic acid has a stronger affinity (2.57), as shown by the partition coefficient test. UV-visible spectra analysis reveals critical compound insights. Fourier-transform infrared (FTIR) identifies significant peaks in itraconazole and related compounds. tween 80 is selected for solid lipid nanoparticles (SLN) based on their appearance. Optimization using 0.5% w/v tween 80 yielded better particle capture. Thermal analyses display distinctive characteristics of i

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Martin, Alexander J., David M. Shackleford, Susan A. Charman, Kylie M. Wagstaff, Christopher J. H. Porter, and David A. Jans. "Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus." Pharmaceutics 15, no. 7 (2023): 1974. http://dx.doi.org/10.3390/pharmaceutics15071974.

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N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established safety record, but there are challenges to its clinical use. This study evaluated the in vivo exposure profile of a 4-HPR dosage regime previously shown to be effective in a mouse model of severe dengue virus (DENV) infection, comparing it to an existing formulation for human clinical use for other indications and developed/characterised self-emulsifying lipid-based formulations of 4-HPR to enhance 4-HPR in vivo exposure. Pharmacokineti

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Tarsitano, Martine, Maria Chiara Cristiano, Antonia Mancuso, Antonella Barone, Daniele Torella, and Donatella Paolino. "Lipid-Based Formulations Containing Labrafil M2125-CS: A Deep Investigation on Nanosystem Stability." Nanomanufacturing 2, no. 1 (2022): 41–52. http://dx.doi.org/10.3390/nanomanufacturing2010003.

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Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth the stability of lipid-based nanosystems when exposed at several experimental conditions, such as temperature- and pH-variations, and during a specific storage process—lyophilization. Dynamic light scattering was the main analysis carried out during this research work for investigating eventual physico-chemical variations of nanosystem properties after differe

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Hasan Zadeh Navroodi, Maryam, Morteza Marashi, Faezeh Talaei, et al. "Basics of Solid Lipid Nanoparticles Formulation." Biomedical Research Bulletin 2, no. 3 (2024): 133–39. https://doi.org/10.34172/biomedrb.2024.20.

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Lipid nanoparticles (LNPs) have captured significant attention in the past few years and are widely used. Nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) are two lipid-based NPs with potential applications in research, drug delivery, cosmetics, and other fields. By modifying the size range, they can be used through different routes. Physically stable and targeted SLNs with good release profiles have been designed to overcome the limitations of emulsions and liposomes. NLCs are modified SLNs that enhance loading capacity and stability. Regardless of the preparation met

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Chen, Jie, Leila Dehabadi, Yuan-Chun Ma, and Lee D. Wilson. "Development of Novel Lipid-Based Formulations for Water-Soluble Vitamin C versus Fat-Soluble Vitamin D3." Bioengineering 9, no. 12 (2022): 819. http://dx.doi.org/10.3390/bioengineering9120819.

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The aim of this study was to develop a facile and novel lipid-based formulation of vitamin C and vitamin D3. Liposomes loaded with vitamin C and D3 were characterized using transmission electron microscopy (TEM) and zeta potential measurements for evaluating morphology, particle size and physical stability. HPLC was employed to quantify the content of vitamin C and vitamin D3 in their liposomal forms. The UHPLC analysis of the lipid-based vitamin formulation is an easy and rapid method for the characterization as well as the quantification of all components. In addition, encapsulation efficien

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Okada, Akie, Rina Niki, Yutaka Inoue, et al. "Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate." Pharmaceutics 14, no. 4 (2022): 785. http://dx.doi.org/10.3390/pharmaceutics14040785.

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In recent years, the development of self-injectable formulations has attracted much attention, and the development of formulations to control pharmacokinetics, as well as drug release and migration in the skin, has become an active research area. In the present study, the development of a lipid-based depot formulation containing leuprorelin acetate (LA) as an easily metabolizable drug in the skin was prepared with a novel non-lamellar liquid-crystal-forming lipid of mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE). Small-angle X-ray scattering, cryo-transmission electron microscop

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Bova, Stefania, Serena Faggiano, Omar De Bei, et al. "Labeled Bovine Serum Albumin as a Fluorescent Biosensor to Monitor the Stability of Lipid-Based Formulations." Biosensors 15, no. 7 (2025): 425. https://doi.org/10.3390/bios15070425.

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In the pharmaceutical field, lipid-based nanoparticles are extensively used for drug or vaccine delivery, particularly for treating respiratory disorders. However, their physico-chemical instability, particularly associated with lipid degradation through hydrolysis or oxidation, can affect their encapsulation properties. To monitor the stability of lipid-based formulations over time, we prepared acrylodan-labeled bovine serum albumin (here called albuminodan), and showed it is a fluorescent biosensor capable of concomitantly detect phospholipids as well as their degradation products, i.e., fat

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Pham, Anna, Paul D. Gavin, Roksan Libinaki, Gisela Ramirez, Jamal T. Khan, and Ben J. Boyd. "Differential Effects of TPM, A Phosphorylated Tocopherol Mixture, and Other Tocopherol Derivatives as Excipients for Enhancing the Solubilization of Co-Enzyme Q10 as a Lipophilic Drug During Digestion of Lipid- Based Formulations." Current Drug Delivery 16, no. 7 (2019): 628–36. http://dx.doi.org/10.2174/1567201816666190806114022.

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Background: The tocopherol-based excipient, TPM, when incorporated into a medium-chain triglyceride (MCT)-based lipid formulation, has been previously shown to improve the solubilization of Coenzyme Q10 (CoQ10) during in vitro digestion which is strongly correlated with enhanced exposure in vivo. Methods: The current study aimed to gain further understanding of the MCT + TPM co-formulation, by assessing the formulation performance under fasted and fed in vitro digestion conditions, with different drug and excipient loading levels. Natural and synthetic-derived TPM were equivalent, and with d-α

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Ankita, S. Dhopate, A. Katekar Vinayak, and T. Hemke Atul. "Exploring lipids: A comprehensive review on their utilization in the formulation of liposomes, phytosomes, and ethosomes for advanced drug delivery systems"." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 099–115. https://doi.org/10.5281/zenodo.14676333.

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This comprehensive review explores the diverse applications of lipids in the formulation of advanced drug delivery systems, specifically focusing on liposomes, phytosomes, and ethosomes. Lipids, crucial components in these formulations, play a pivotal role in enhancing drug solubility, stability, and bioavailability. The review systematically examines the latest advancements in lipid-based delivery systems, shedding light on their unique characteristics and applications. In the realm of liposomes, the study delves into various lipid compositions, highlighting their influence on liposomal struc

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Tomou, Ekaterina-Michaela, Paraskevi Papakyriakopoulou, Elmina-Marina Saitani, Georgia Valsami, Natassa Pippa, and Helen Skaltsa. "Recent Advances in Nanoformulations for Quercetin Delivery." Pharmaceutics 15, no. 6 (2023): 1656. http://dx.doi.org/10.3390/pharmaceutics15061656.

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Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE’s low solubility and extended first-pass metabolism limit its oral administration. This review aims to present the potential of various nanoformulations in the development of QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used for more efficient encapsulation, targeting, and controlled release of QUE. An overview of the primary nanosystem categories, formulation processes, and characteriza

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