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Journal articles on the topic 'Madge Kinsey Players'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Hatzimanouil, Dimitris, Jose M. Saavedra, Nikos Stavropoulos, Vasilis Skandalis, and Konstantinos Gkagkanas. "ATTACK TACTICS IN ELITE BEACH HANDBALL TEAMS." Kinesiologia Slovenica 26, no. 1 (2020): 46–56. http://dx.doi.org/10.52165/kinsi.26.1.46-56.

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Beach handball is a highly popular sport, but research information and data about it is limited. The aim of this study was to determine the most effective tactics for the shots made to be more successful. Overall, 1074 attacks from the 2017 European Beach Handball Championship were analysed. The variables analysed were shots at goal and their efficiency (video-analysis). The chi-squared test was used to compare the differences between formations (initial vs final attack formation). A Wilcoxon test was used to compare differences between the final attack formations with respect to goals, misses

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Dana, Dibyendu, Tuhin Das, Athena Choi, et al. "Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development." Molecules 27, no. 2 (2022): 347. http://dx.doi.org/10.3390/molecules27020347.

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Cell cycle kinases represent an important component of the cell machinery that controls signal transduction involved in cell proliferation, growth, and differentiation. Nek2 is a mitotic Ser/Thr kinase that localizes predominantly to centrosomes and kinetochores and orchestrates centrosome disjunction and faithful chromosomal segregation. Its activity is tightly regulated during the cell cycle with the help of other kinases and phosphatases and via proteasomal degradation. Increased levels of Nek2 kinase can promote centrosome amplification (CA), mitotic defects, chromosome instability (CIN),

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3

Erčulj, Frane, Marko Marković, Bojan Leskošek, and Matej Supej. "INTER-RATER RELIABILITY OF CERTAIN PARAMETERS OF BASKETBALL JUMP SHOT." Kinesiologia Slovenica 27, no. 3 (2021): 5–20. http://dx.doi.org/10.52165/kinsi.27.3.5-20.

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in sport training practice. The aim of this study was to establish whether basketball coaches are capable of uniformly (congruently) evaluating the release time, release angle, ball rotation and overall correctness of a jump shot by observing it with the naked eye. The study included a sample of 13 coaches (six with more and seven with less experience) whose task was to evaluate basketball jump shots made by young basketball players aged 15.1 (± 0.75) years on average from a distance of 4.5 m. The values of Pearson’s correlation coefficients and multiple correlation coefficients (generally abo

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4

Ji, Guangchen, and Volker Neugebauer. "Pro- and Anti-Nociceptive Effects of Corticotropin-Releasing Factor (CRF) in Central Amygdala Neurons Are Mediated Through Different Receptors." Journal of Neurophysiology 99, no. 3 (2008): 1201–12. http://dx.doi.org/10.1152/jn.01148.2007.

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Corticotropin-releasing factor (CRF) is not only a stress hormone but also acts as a neuromodulator outside the hypothalamic-pituitary-adrenocortical axis, playing an important role in anxiety, depression, and pain modulation. The underlying mechanisms remain to be determined. A major site of extra-hypothalamic expression of CRF and its receptors is the amygdala, a key player in affect-related disorders such as anxiety. The latero-capsular division of the central nucleus of the amygdala (CeLC) is also important for pain modulation and pain affect. This study analyzed the effects of CRF on noci

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Dhiman, Pratibha, and Priyanka Saxena. "JAK2V617F: Is It Sufficient as a Single Player in Splanchnic Venous Thrombosis?" Case Reports in Hematology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/373490.

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Splanchnic venous thrombosis (SVT) includes thrombosis of the hepatic, portal, and mesenteric venous system. Myeloproliferative neoplasms (MPNs) are important factors of SVT in adults. Addition of JAK2V617F mutation in WHO criteria for diagnosis of MPNs has made this test a useful tool for diagnosis. JAK2 is an intracytoplasmic tyrosine kinase that plays a critical role in signal transduction from multiple hematopoietic factor receptors. The mutation is found frequently in patients with SVT; many such patients have no other manifestations of an MPN. Although the correlation of JAK2V617F mutati

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DESSAUGE, F., R. LIZUNDIA, and G. LANGSLEY. "Constitutively activated CK2 potentially plays a pivotal role in Theileria-induced lymphocyte transformation." Parasitology 130, S1 (2005): S37—S44. http://dx.doi.org/10.1017/s0031182005008140.

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Activation of casein kinase II (CK2) was one of the first observations made on how Theileria parasites manipulate host cell signal transduction pathways and we argue that CK2 induction may in fact contribute to many of the different activation events that have been described since 1993 for Theileria-infected lymphocytes such as sustained activation of transcription factors c-Myc and NF-κB. CK2 also contributes to infected lymphocyte survival by inhibiting caspase activation and is probably behind constitutive PI3-K activation by phosphorylating PTEN. Finally, we also discuss how CK2A may act n

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García-García, Raquel, Laura Martín-Herrero, Laura Blanca-Pariente, Jesús Pérez-Cabello, and Cintia Roodveldt. "Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)." International Journal of Molecular Sciences 22, no. 24 (2021): 13280. http://dx.doi.org/10.3390/ijms222413280.

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Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median survival of 3–5 years after appearance of symptoms, and with no curative treatment currently available. Frontotemporal dementia (FTD) is also an adult-onset neurodegenerative disease, displaying not only clinical overlap with ALS, but also significant similarities at genetic and pathologic levels. Apart from the progressive loss of neurons and the accumulation of protein inclusions in certain cells and tissues, both disorders are characterized by chronic inflammation medi

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Su, Han, Xiaohu Jiang, Yanfen Liu, et al. "Advances in ERECTA Family Regulation of Female Gametophyte Development in Arabidopsis thaliana." Plants 14, no. 13 (2025): 1900. https://doi.org/10.3390/plants14131900.

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The female gametophyte is central to the reproductive success of flowering plants, with its development being tightly controlled by an intricate network of genes and signaling pathways. A deeper understanding of these regulatory mechanisms is essential for uncovering the complexities of plant growth and development. Recent studies have shed light on various aspects of female gametophyte development, highlighting the role of specific gene and signaling networks. Among these, the ERECTA family of leucine-rich repeat receptor-like kinase (RLK) in Arabidopsis thaliana has emerged as a key player,

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Sin, Alex T. W., and Rene E. Harrison. "Growth of the Mammalian Golgi Apparatus during Interphase." Molecular and Cellular Biology 36, no. 18 (2016): 2344–59. http://dx.doi.org/10.1128/mcb.00046-16.

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During the cell cycle, genetic materials and organelles are duplicated to ensure that there is sufficient cellular content for daughter cells. While Golgi growth in interphase has been observed in lower eukaryotes, the elaborate ribbon structure of the mammalian Golgi apparatus has made it challenging to monitor. Here we demonstrate the growth of the mammalian Golgi apparatus in its protein content and volume during interphase. Through ultrastructural analyses, physical growth of the Golgi apparatus was revealed to occur by cisternal elongation of the individual Golgi stacks. By examining the

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Baumgart, Simon J., Ekaterina Nevedomskaya, and Bernard Haendler. "Dysregulated Transcriptional Control in Prostate Cancer." International Journal of Molecular Sciences 20, no. 12 (2019): 2883. http://dx.doi.org/10.3390/ijms20122883.

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Recent advances in whole-genome and transcriptome sequencing of prostate cancer at different stages indicate that a large number of mutations found in tumors are present in non-protein coding regions of the genome and lead to dysregulated gene expression. Single nucleotide variations and small mutations affecting the recruitment of transcription factor complexes to DNA regulatory elements are observed in an increasing number of cases. Genomic rearrangements may position coding regions under the novel control of regulatory elements, as exemplified by the TMPRSS2-ERG fusion and the amplified enh

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Wengner, Antje M., Arne Scholz, and Bernard Haendler. "Targeting DNA Damage Response in Prostate and Breast Cancer." International Journal of Molecular Sciences 21, no. 21 (2020): 8273. http://dx.doi.org/10.3390/ijms21218273.

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Steroid hormone signaling induces vast gene expression programs which necessitate the local formation of transcription factories at regulatory regions and large-scale alterations of the genome architecture to allow communication among distantly related cis-acting regions. This involves major stress at the genomic DNA level. Transcriptionally active regions are generally instable and prone to breakage due to the torsional stress and local depletion of nucleosomes that make DNA more accessible to damaging agents. A dedicated DNA damage response (DDR) is therefore essential to maintain genome int

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Mexis, Dimitrios, Tzortzis Nomikos, and Nikolaos Kostopoulos. "Effect of Three Pre-Season Training Protocols with Different Training Frequencies on Biochemical and Performance Markers in Professional Female Basketball Players." Applied Sciences 15, no. 4 (2025): 1833. https://doi.org/10.3390/app15041833.

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This study examined the impact of three pre-season fitness training protocols with different training frequencies (heavy, moderate and light) on the physical abilities and the biochemical indicators of muscle damage and oxidative stress in female basketball athletes as expressed through physiological and biochemical assessments. Also, a comparison and a search for correlations were made between the physiological and biochemical changes that were caused by each protocol. The sample consisted of 28 professional female basketball athletes, who competed in three different teams, and each training

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Kordowitzki, Pawel. "Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging." Cells 13, no. 18 (2024): 1592. http://dx.doi.org/10.3390/cells13181592.

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The field of reproductive biology has made significant progress in recent years, identifying specific molecular players that influence oocyte development and function. Among them, sirtuin 3 (SIRT3) has attracted particular attention for its central role in mediating mitochondrial function and cellular stress responses in oocytes. So far, studies have demonstrated that the knockdown of SIRT3 leads to a decrease in blastocyst formation and an increase in oxidative stress within an embryo, underscoring the importance of SIRT3 in maintaining the cellular redox balance critical for embryonic surviv

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Wang, J. Y. J., and S. W. Ki. "Choosing between growth arrest and apoptosis through the retinoblastoma tumour suppressor protein, Abl and p73." Biochemical Society Transactions 29, no. 6 (2001): 666–73. http://dx.doi.org/10.1042/bst0290666.

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The choice between growth arrest and apoptosis is made during differentiation, leading to survival with permanent arrest (e.g. neurons), or to death (e.g. epithelium). Genotoxic stress can also cause growth arrest or apoptosis, in addition to the activation of cell cycle checkpoint pathways. The p53 tumour suppressor can simulate growth arrest and apoptosis in response to DNA damage. Thus, p53 alone is not sufficient to specify these two mutually exclusive fates in damaged cells. The retinoblastoma tumour suppressor protein (RB) is a necessary downstream effector in p53-mediated growth arrest.

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15

Rojas-Valverde, Daniel, Ismael Martínez-Guardado, Braulio Sánchez-Ureña, et al. "Outpatient Assessment of Mechanical Load, Heat Strain and Dehydration as Causes of Transitional Acute Kidney Injury in Endurance Trail Runners." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 10217. http://dx.doi.org/10.3390/ijerph181910217.

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Background: This study aimed to globally assess heat strain, dehydration, and mechanical load as acute kidney injury (AKI) indicators in amateur endurance trail athletes during a 35.3 km run. Methods: Thirty amateur experienced trail runners completed an endurance trail run (total positive ascend 1815 m). The following assessments were performed at four measurement time points (pre-, during, immediately post [-post0h], and after 24 h of the finish of the run [-post24h]): serum test (creatinine, blood ureic nitrogen, albumin, creatine kinase, blood ureic nitrogen: creatinine ratio, creatinine c

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Sauter, Reinhard Joerg, Manuela Sauter, Edimara S. Reis, et al. "Anaphylatoxin receptor C3aR on platelets participates in platelet function and links innate immunity with thrombosis." Journal of Immunology 202, no. 1_Supplement (2019): 126.25. http://dx.doi.org/10.4049/jimmunol.202.supp.126.25.

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Abstract Background Beyond the superficial function of blood coagulation, platelets play an important role in the genesis of vascular inflammatory processes. Interestingly, platelets express the complement receptor C3aR. Here, we examine the role of the complement receptor C3aR on platelets for platelet function and in diseases. Methods We detected the expression of C3aR on murine and human platelets using western blot and flow cytometry. We examined proteins, that are in close connection to the C3aR receptor on platelets by mass spectrometry to elucidate the intracellular signaling. We examin

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Poggio, Teresa, Linda Graessel, Stefanie Kreutmair, et al. "Examining the Role of CD30 in an Anaplastic Large Cell Lymphoma Mouse Model." Blood 134, Supplement_1 (2019): 2542. http://dx.doi.org/10.1182/blood-2019-125589.

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Anaplastic large cell lymphoma (ALCL) represents a heterogeneous group of T-cell non-Hodgkin lymphoma (NHL) mainly affecting children and young adults. About 70% of systemic ALCLs are associated with a characteristic chromosomal translocation, t(2;5)(p23;35) which fuses the anaplastic lymphoma kinase (ALK) gene on chromosome 2 with the nucleophosmin (NPM) gene on chromosome 5, resulting in the NPM-ALK fusion gene, its over-expression and constitutive kinase activity. Immunophenotypic characterization of human ALCL revealed highly CD30-positive cells of T- or Null-Cell-origin and resulted in pr

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18

Frier, Bruce C., Deon B. Williams, and David C. Wright. "The effects of apelin treatment on skeletal muscle mitochondrial content." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, no. 6 (2009): R1761—R1768. http://dx.doi.org/10.1152/ajpregu.00422.2009.

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Adipose tissue is recognized as a key player in the regulation of whole body metabolism. Apelin, is a recently identified adipokine that when given to mice results in increases in skeletal muscle uncoupling protein 3 (UCP3) content. Similarly, acute apelin treatment has been shown to increase the activity of 5′-AMP-activated protein kinase (AMPK), a reputed mediator of skeletal muscle mitochondrial biogenesis. Given these findings, we sought to determine the effects of apelin on skeletal muscle mitochondrial content. Male Wistar rats were given daily intraperitoneal injections of apelin-13 (10

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Oyelami, Felix F., Andrew T. Shinkle, Chrispus M. Ngule, et al. "Abstract 1615: Targeting PGK1 to enhance ferroptosis in breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 1615. https://doi.org/10.1158/1538-7445.am2025-1615.

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Abstract A key feature common to triple-negative breast cancer is metabolic reprogramming that contributes to the malignant phenotype. Dysregulation of phosphoglycerate kinase 1 (PGK1), an essential player in glycolysis, is involved in several oncogenic pathways. In the current study, we aimed to determine whether PGK1-mediated glucose metabolism impacts the induction of ferroptosis in breast cancer. We found that expression of PGK1 varies in TNBC cell lines, with MDA-MB-231, MDA-MB-458 and MDAMB-453 lines showing significantly higher PGK1 expression than BT-549 and HCC70, and than the luminal

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Vaughn-Beaucaire, Philippa C., Sean Lawler, Anke Bruning-Richardson, William Hawkins, Jorge Jimenez-Macias, and Praveen Srinivasan. "Abstract A011: Stopping brain tumors in their tracks: the role of RhoGTPase activating proteins (ARHGAPs) in glioma cell migration and invasion." Cancer Research 84, no. 5_Supplement_1 (2024): A011. http://dx.doi.org/10.1158/1538-7445.brain23-a011.

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Abstract Despite efforts to improve outcomes, patients diagnosed with glioblastoma (GBM) have a median survival of only 12-15 months. Tumors are characterized by rapid growth and invasion. We previously have shown that the broadly selective kinase inhibitor (2'Z,3'E)-6-Bromoindirubin-3'-oxime (BIO) has potent anti-migratory properties in GBM cells. To investigate the mechanisms involved we performed transcriptomic analysis which showed a wide range of alterations in GBM cell lines associated with BIO treatment. This included multiple members of the RhoGTPase activating protein (ARHGAP) family.

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Jedema, Inge, Linda van Dreunen, Renate S. Hagedoorn, and J. H. Frederik Falkenburg. "Multi-Dimensional Resistance Phenotype Allows Subpopulation of Quiescent Chronic Myeloid Leukemia Stem Cells to Universally Escape From Therapeutic Attack." Blood 116, no. 21 (2010): 203. http://dx.doi.org/10.1182/blood.v116.21.203.203.

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Abstract Abstract 203 Chronic myeloid leukemia (CML) is well responsive to various therapeutic strategies, including conventional chemotherapy, tyrosine kinase inhibitors (TKI), but also allogeneic stem cell transplantation combined with donor lymphocyte infusions (DLI). Although initial complete responses are frequently achieved, recurrence of the disease is a common phenomenon occurring sometimes years after the therapeutic intervention(s). Although acquired resistance is sometimes observed, the majority of relapses can be controlled with re-introduction of therapeutic pressure. This indicat

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Pechanska, Paulina, Joachim Kunz, Tobias Rausch, et al. "Gene Panel Sequencing of Primary and Relapsed Pediatric T-ALL Shows That Relapse-Specific Mutations Are Diverse and Mostly Non-Recurrent." Blood 126, no. 23 (2015): 1428. http://dx.doi.org/10.1182/blood.v126.23.1428.1428.

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Abstract Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains one of the major challenges of pediatric oncology, because relapses are frequently refractory to treatment and fatal. We aimed at identifying relapse specific genetic alterations by analyzing a cohort of 147 primary T-ALL patients and of 70 relapsed T-ALL patients with targeted gene panel sequencing. In addition to the analysis of single nucleotide variants (SNVs) and small insertions and deletions (InDels), we made use of the available coverage data to characterize aberrant copy number alterations (CNA). DNA from bone marr

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Saadat, Somayeh, Mahdi Noureddini, Maryam Mahjoubin-Tehran та ін. "Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players". Frontiers in Cardiovascular Medicine 7 (25 січня 2021). http://dx.doi.org/10.3389/fcvm.2020.588347.

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Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle. Transforming growth factor β (TGF-β) as a pivotal cytokine/growth factor stimulates fibroblasts and hastens ECM production in injured tissues. The TGF-β receptor is a heterodimeric receptor complex on the plasma membrane, made up from TGF-β type I, as well as type II receptors, giving rise to Smad2 and Smad3 transcription factors phosphorylation upon canonical signaling. Phosphorylated Smad2, Smad3, an

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He, Shuo, Yan Liang, Yiyi Tan, et al. "Positioning determines function: Wandering PKM2 performs different roles in tumor cells." Cell Biology International, November 17, 2023. http://dx.doi.org/10.1002/cbin.12103.

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AbstractShort for pyruvate kinase M2 subtype, PKM2 can be said of all‐round player that is notoriously known for its metabolic involvement in glycolysis. Holding a dural role as a metabolic or non‐metabolic (kinase) enzyme, PKM2 has drawn extensive attention over its biological roles implicated in tumor cells, including proliferation, migration, invasion, metabolism, and so on. wandering PKM2 can be transboundary both intracellularly and extracellularly. Specifically, PKM2 can be nuclear, cytoplasmic, mitochondrial, exosomal, or even circulate within the body. Importantly, PKM2 can function as

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Shah, Kamal, Krishan Gopal, Shivendra Kumar, and Sunam Saha. "Emerging AXL Inhibitors in Oncology: Chemical and Biological Advances in Targeted Cancer Therapy." Anti-Cancer Agents in Medicinal Chemistry 25 (December 13, 2024). https://doi.org/10.2174/0118715206351185241209053053.

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Abstract: AXL, a receptor tyrosine kinase, has emerged as a critical player in tumorigenesis, metastasis, and resistance to conventional therapies. Its aberrant activation drives cell proliferation, survival, and angiogenesis, making it an attractive target for cancer treatment. In recent years, significant progress has been made in the development of AXL inhibitors. Chemical approaches have led to the discovery of small molecules that selectively bind to and inhibit AXL, disrupting its downstream signaling pathways. These inhibitors exhibit diverse structural features, including ATP-competiti

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Chen, Qiumin, Shuang Zhou, Mengqi Qu, et al. "Cucumber (Cucumis sativus L.) translationally controlled tumor protein interacts with CsRab11A and promotes activation of target of rapamycin in response to Podosphaera xanthii." Plant Journal, May 3, 2024. http://dx.doi.org/10.1111/tpj.16766.

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SUMMARYThe target of rapamycin (TOR) kinase serves as a central regulator that integrates nutrient and energy signals to orchestrate cellular and organismal physiology in both animals and plants. Despite significant advancements having been made in understanding the molecular and cellular functions of plant TOR kinases, the upstream regulators that modulate TOR activity are not yet fully elucidated. In animals, the translationally controlled tumor protein (TCTP) is recognized as a key player in TOR signaling. This study reveals that two TCTP isoforms from Cucumis sativus, when introduced into

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Desbois, Muriel, and Brock Grill. "Molecular regulation of axon termination in mechanosensory neurons." Development 151, no. 17 (2024). http://dx.doi.org/10.1242/dev.202945.

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ABSTRACT Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation or gentle touch have proven exceptionally valuable for studying axon termination over the past 40 years. In this Review, we discuss progress made in deciphering the molecular and genetic mechanisms that govern axon termination in touch receptor neurons. Findings across model organisms, including Caenorhabditis elegans, Drosophila, zebrafis

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Tsai, Pei-Jane, Yi-Hsin Lai, Rajesh Kumar Manne, Yau-Sheng Tsai, Dos Sarbassov, and Hui-Kuan Lin. "Akt: a key transducer in cancer." Journal of Biomedical Science 29, no. 1 (2022). http://dx.doi.org/10.1186/s12929-022-00860-9.

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AbstractGrowth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player transmitting extracellular clues to various cellular compartments, in turn executing these biological processes. Since the discovery of Akt three decades ago, the tremendous progress towards identifying its upstream regulators and downstream effectors and its roles in cancer has been made, offering novel paradigms and therapeutic strategies for targeting huma

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Tessarollo, Lino, and Sudhirkumar Yanpallewar. "TrkB Truncated Isoform Receptors as Transducers and Determinants of BDNF Functions." Frontiers in Neuroscience 16 (March 7, 2022). http://dx.doi.org/10.3389/fnins.2022.847572.

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Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted growth factors and binds with high affinity to the TrkB tyrosine kinase receptors. BDNF is a critical player in the development of the central (CNS) and peripheral (PNS) nervous system of vertebrates and its strong pro-survival function on neurons has attracted great interest as a potential therapeutic target for the management of neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS), Huntington, Parkinson’s and Alzheimer’s disease. The TrkB gene, in addition to the full-length receptor, e

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Bortolami, Alessandro, Wei Yu, Elena Forzisi, et al. "Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy." Cell Death & Differentiation, October 7, 2022. http://dx.doi.org/10.1038/s41418-022-01072-2.

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AbstractPotassium (K+) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K+ channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of glutamatergic neurons was impaired in the neocortices of KCNB1 null mice. Migratory defects persisted into the adult brains, along with disrupted morphology and synaptic connectivity. Mice developed seizure phenotype, anxiety, and compulsive behavior. To determine whether defective KCNB1 can g

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Fasouli, Eirini Sofia, and Eleni Katsantoni. "Age‐associated myeloid malignancies – the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia." FEBS Letters, July 24, 2024. http://dx.doi.org/10.1002/1873-3468.14985.

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In the last few decades, the increasing human life expectancy has led to the inflation of the elderly population and consequently the escalation of age‐related disorders. Biological aging has been associated with the accumulation of somatic mutations in the Hematopoietic Stem Cell (HSC) compartment, providing a fitness advantage to the HSCs leading to clonal hematopoiesis, that includes non‐malignant and malignant conditions (i.e. Clonal Hematopoiesis of Indeterminate Potential, Myelodysplastic Syndrome and Acute Myeloid Leukemia). The Janus Kinase‐Signal Transducer and Activator of Transcript

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Hernandez, Rebecca, та Changcheng Zhou. "Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases". Frontiers in Cardiovascular Medicine 8 (8 грудня 2021). http://dx.doi.org/10.3389/fcvm.2021.752337.

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Cardiometabolic diseases, including cardiovascular disease, obesity, and diabetes, are the leading cause of mortality and morbidity worldwide. Cardiometabolic diseases are associated with many overlapping metabolic syndromes such as hypertension, hyperlipidemia, insulin resistance, and central adiposity. However, the underlying causes of cardiometabolic diseases and associated syndromes remain poorly understood. Within the past couple of decades, considerable progresses have been made to understand the role of inflammatory signaling in the pathogenesis of cardiometabolic diseases. The transcri

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Su, You-Qiang, Yaoxue Yin, Jing Guo, Xuhong Gong, Yufeng Tian, and Lanying Shi. "MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in mice." Biology of Reproduction, May 12, 2022. http://dx.doi.org/10.1093/biolre/ioac099.

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Abstract Coordinated development of the germline and the somatic compartments within a follicle is an essential prerequisite for creating a functionally normal oocyte. Bi-directional communication between the oocyte and the granulosa cells enables the frequent interchange of metabolites and signals that support the development and functions of both compartments. Mechanistic target of Rapamycin (MTOR), a conserved serine/threonine kinase and a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation, is emerging as a major player that

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Mlynek, Arne, Margarete Lukosz, Karl Köhrer, et al. "Abstract 543: The Janus-Faced Transcription Factor Sister-of-Mammalian Grainyhead: 2 Isoforms with Opposing Effects in Endothelial Cells and in Vivo." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a543.

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Maintenance of apoptosis protection and migratory capacity are absolutely required for proper endothelial function. Several pathways are described, which are necessary for these processes including activation of the protein kinase B (Akt) and the endothelial nitric oxide synthase (eNOS). Recently, we identified a new player, the transcription factor sister-of-mammalian grainyhead (SOM)/Grainyhead-like 3, which demonstrated anti-apoptotic and pro-migratory properties in endothelial cells (EC). In humans, three isoforms of SOM are expressed, two of which, SOM1 and SOM3, are derived from an alter

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Parmar, Nitika. "Effects of TCTP Over‐expression in Bacteria." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1131.3.

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TCTP (Tumor protein, translationally‐controlled 1) has been implicated in many cellular functions that are related to growth. TCTP has been shown to interact with the G‐protein Rheb, a key player of the PI3 Kinase/mTOR signal transduction pathway and thought to function as its GEF (Guanine Nucleotide Exchange Factor). This study was designed to understand the effects and role of TCTP in prokaryotic physiology. Although no homologs of TCTP have been found in prokaryotes, the expression of wild type and a mutant version of mammalian TCTP on bacterial metabolism under stress conditions was invest

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Borroto‐Escuela, Dasiel O., Alexander O. Tarakanov, and Kjell Fuxé. "FGFR1–5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression." Trends in Neurosciences 39, no. 1 (2016). https://doi.org/10.5281/zenodo.13860084.

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5-HT1A receptor is a 5-HT receptor subtype, which binds the endogenous transmitter 5-hydroxytryptamine. In the brain it participates in mediating antidepressant effects of classical antidepressant drugs and of serotonin selective reuptake inhibitors. FGFR1 is a receptor tyrosine kinase, the ligands of which are specific members of the fibroblast growth factor family. One of its ligands, FGF2, is shown to produce antidepressant-like effects. FGFR1–5-HT1A heteroreceptor complexes were recently discovered in the brain. In these heterocomplexes, agonist coactivation markedly enhanced FGFR1 signali

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Connor, Will. "Positively Monstrous!" M/C Journal 24, no. 5 (2021). http://dx.doi.org/10.5204/mcj.2822.

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Bones are one of the oldest materials used to create musical instruments. Currently, the world’s oldest known instruments are flutes made out of bones (Turk, Turk, and Otte 11). In fact, bones have been used to create or enhance musical instruments in a variety of settings throughout history and in modern day instrument making. Bone bull roarers, jaw bone percussion, clappers, trumpets, drum shells, lyres, or construction parts, such as frets, plectrums, pipes and pipe fittings, embouchure adjustments, or percussive strikes are just a few of the more common uses of bones in musical instrument

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Abjamilova, Jazgul, Abhinav Kumar Sharma, Kartikay Dhillon, Deepak, and Avtar Singh. "Jazgul Abjamilova's Article - Thyroid Hormonal Responses to Biological Treatments Understanding Their Role in Rheumatoid Arthritis." May 10, 2025. https://doi.org/10.5281/zenodo.15380542.

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    Thyroid Hormonal Responses to Biological Treatments Understanding Their Role in Rheumatoid Arthritis   Article By Kartikay Dhillon Avtar Singh Deepak Abhinav Kumar Sharma Email : abhinavosh13@gmail.com   Under the Guidance of Jazgul Abjamilova Deptt of Pediatrics ORCID - https://orcid.org/0000-0001-8028-3343   Abstract Living with rheumatoid arthritis (RA) means navigating a world of joint pain, fatigue, and the constant push to find treatments that restore balance to an overactive immune system. Biological therapies, like TNF inhibitors and IL-6 blockers, have bee

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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