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Journal articles on the topic 'Malonic acid derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Xavier, Tania, Sylvie Condon, Christophe Pichon, Erwan Le Gall, and Marc Presset. "Preparation of mono-substituted malonic acid half oxyesters (SMAHOs)." Beilstein Journal of Organic Chemistry 17 (August 18, 2021): 2085–94. http://dx.doi.org/10.3762/bjoc.17.135.

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The use of mono-substituted malonic acid half oxyesters (SMAHOs) has been hampered by the sporadic references describing their preparation. An evaluation of different approaches has been achieved, allowing to define the best strategies to introduce diversity on both the malonic position and the ester function. A classical alkylation step of a malonate by an alkyl halide followed by a monosaponification gave access to reagents bearing different substituents at the malonic position, including functionalized derivatives. On the other hand, the development of a monoesterification step of a substit

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2

Berhow, Mark A., Raymond D. Bennett, Katherine Kanes, Stephen M. Poling, and Carl E. Vandercook. "A malonic acid ester derivative of naringin in grapefruit." Phytochemistry 30, no. 12 (1991): 4198–200. http://dx.doi.org/10.1016/0031-9422(91)83505-f.

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3

Grishina, A. Yu, D. Yu Ivkin, S. M. Napalkova, and O. V. Buyuklinskaya. "Quality Assurance System when Studying the Pharmacological Safety of Etmaben." Journal Biomed 20, no. 3 (2024): 71–74. http://dx.doi.org/10.33647/2074-5982-20-3-71-74.

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Quality assurance plays a key role in preclinical research, where every detail must be strictly controlled and verified. Standard operating procedures are essential part of any quality assurance system, defining precisely the steps and methods of implementing certain tasks or processes in a laboratory. In this article, the main components of a quality assurance system are discussed using the example of studying the pharmacological safety of a malonic acid derivative.

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4

Ivkin, D. Yu, M. V. Krasnova, E. D. Semivelichenko, A. A. Karpov, V. E. Kovanskov, and S. V. Okovitiy. "Comparative Efficacy of Etmaben and Empagliflozin in Mono- and Combined Therapy of Experimental Chronic Heart Failure." Journal Biomed 20, no. 3E (2024): 187–90. http://dx.doi.org/10.33647/2713-0428-20-3e-187-190.

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The cardiotropic activity of etmaben, a malonic acid derivative, has been confirmed by a number of studies. The possibility of using empagliflozin in chronic heart failure has been proven in a number of preclinical and clinical studies. In this study, the efficacy of the drugs in monotherapy and combined use regimens is compared using a model of experimental chronic heart failure in rats. The most effective treatment regimen was found to be etmaben; its combination with empagliflozin led to a decrease in effectiveness, regardless of which of these drugs was the starting drug.

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5

Yang, Xinlin, Lin Chen, Xinge Qiao, and Cuihong Fan. "Photo-Induced Damages of Cytoplasmic and Mitochondrial Membranes by a [C60]Fullerene Malonic Acid Derivative." International Journal of Toxicology 26, no. 3 (2007): 197–201. http://dx.doi.org/10.1080/10915810701352606.

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The biological activities of fullerene derivatives have attracted much attention in the last decade. In this paper, effects of dimalonic acid C60 (DMA C60) on cytoplasmic membrane, intracellular calcium concentration ([Ca2+]i), and mitochondrial membrane in HeLa cells were studied by using laser scanning confocal microscopy together with fluorescent probes propidium iodide (PI), fluo-3 acetoxymethyl ester (fluo-3 AM), and tetramethyl rhodamine methyl ester (TMRM). The data showed that under laser irradiation produced by a Kr/Ar laser source with a low power less than 1 mW, DMA C60 might induce

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6

Tsao, Nina, Puthuparampil P. Kanakamma, Tien-Yau Luh, Chen-Kung Chou, and Huan-Yao Lei. "Inhibition of Escherichia coli-Induced Meningitis by Carboxyfullerence." Antimicrobial Agents and Chemotherapy 43, no. 9 (1999): 2273–77. http://dx.doi.org/10.1128/aac.43.9.2273.

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ABSTRACT The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose-dependent manner. C60 administered intraperitoneally as late as 9 h after E. coliinjection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1β production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli-induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltrat

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7

Diaz-Ballote, Luis, Luis Maldonado-Lopez, Liliana San-Pedro, Emanuel Hernández-Nuñez, and Juan Genesca. "Glycerol and malonic acid as corrosion inhibitors seen through the density functional theory perspective." Journal of the Serbian Chemical Society, no. 00 (2022): 12. http://dx.doi.org/10.2298/jsc211201012d.

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Glycerol (G) is the major co-product in the transesterification process of biodiesel. As clean energy demand increases, the production of G also increases and new ways of re-using it are needed. In the last decade, some experimental studies claimed that G and its derivative, malonic acid (MA), could be used as corrosion inhibitors. Yet, presently, there is little evidence of it and more studies are needed to confirm that G and MA could have a good performance in metal protection. The present work aims to study the reactivity of G and MA, since reactivity and inhibition are intimately linked. T

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8

Valenta, Vladimír, Zdeněk Vejdělek, Karel Šindelář, and Miroslav Protiva. "Potential anticonvulsants: Some derivatives and analogues of 2-propylpentanoic acid." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1067–76. http://dx.doi.org/10.1135/cccc19901067.

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Reaction of 2-(ethoxycarbonylamino)ethanol with 2-propylpentanoyl chloride gave the ester III. N-(4-Piperidinyl)-2-propylpentanamide (V) was prepared via the 1-benzyl-4-piperidinyl derivative IV and was acylated with ethanesulfonyl chloride and 2-propylpentanoyl chloride to give the amides VI and VII. Malonic ester syntheses afforded diethyl 2-ethyl- and 2-propyl-2-(2-(methylthio)ethyl)malonate VIII and XIII which were hydrolyzed and decarboxylated to the acids X and XV which, in turn, were transformed to the amides XII and XVII. 3-Thiapentanenitrile was alkylated with propyl bromide to the ni

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9

Miyazawa, Kun'ichi, Tadahiko Mashino, and Tadatomo Suga. "Structural characterization of the C60[C(COOC2H5)2] whiskers prepared by the liquid–liquid interfacial precipitation method." Journal of Materials Research 18, no. 11 (2003): 2730–35. http://dx.doi.org/10.1557/jmr.2003.0380.

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Fine whiskers of a C60 derivative, i.e., C60 monosubstituted by ethyl ester of malonic acid, C60[C(COOC2H5)2], were fabricated for the first time using a system of toluene with concentrated C60[C(COOC2H5)2] and isopropyl alcohol. The center-to-center distance of C60[C(COOC2H5)2] molecules along the close-packed direction of the C60[C(COOC2H5)2] whiskers was in the same range as that of the C60 nanowhiskers prepared by the same method. The C60[C(COOC2H5)2] whiskers were assumed to take body-centered tetragonal or hexagonal close-packed crystal structures. The C60[C(COOC2H5)2] whiskers showed a

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10

Werfeli, Ali, Jan Čejka, Ondřej Klecán, Bohumil Kratochvíl, and Josef Kuthan. "Preparation of New Optically Active Furanoids Containing Various Aza-Heterocyclic Moieties." Collection of Czechoslovak Chemical Communications 62, no. 6 (1997): 894–912. http://dx.doi.org/10.1135/cccc19970894.

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The aldehyde 2 prepared from [5-(2,3-O-isopropylidene-β-D-erythrofuranosyl)-2-methylfuran-3-yl]methanol (1) was converted to E,Z-oximes 3, 4 and imine derivative 5 by the reaction with hydroxylamine and pyridin-2-yl amine, respectively. The Knoevenagel reaction with malonic acid afforded exclusively the 3-substituted acrylic acid 6 while corresponding Hantzsch 1,4-dihydropyridines 7 and 8 were obtained by the reaction of aldehyde 2 with ethyl acetoacetate or acetylacetone and ammonia. 3,5-Dicyano-1,4-dihydropyridine derivative 9 was isolated only in forms of hydrates after the reaction of alde

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11

Guldi, Dirk M., Hartmut Hungerbuehler, and Klaus-Dieter Asmus. "Unusual redox behavior of a water soluble malonic acid derivative of C60: evidence for possible cluster formation." Journal of Physical Chemistry 99, no. 36 (1995): 13487–93. http://dx.doi.org/10.1021/j100036a026.

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12

Funakoshi-Tago, Megumi, Yurika Miyagawa, Fumihito Ueda та ін. "A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation". International Immunopharmacology 40 (листопад 2016): 254–64. http://dx.doi.org/10.1016/j.intimp.2016.08.031.

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13

Smirnova, O., I. Kalashnikova, and G. Kurbatov. "MDA PHOTOMETRY IN SOLUTIONS: COMPARISON OF METHODS OF DIRECT OPTICAL DENSITY DATA AND DERIVATIVE SPECTROSCOPY." Russian Journal of Biological Physics and Chemisrty 8, no. 4 (2024): 468–76. http://dx.doi.org/10.29039/rusjbpc.2023.0648.

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In this study, we analyzed the absorption spectra of the reaction products of aqueous extracts of mouse tissues with thiobarbituric acid, with the aim to determine the concentration of malonic dialdehyde (MDA) in them. The concentration of MDA is an important part of the analysis of the redox status of tissues, which is important in the study of inflammatory reactions, for example, after various stressful effects, as well as in the study of aging. In normal practice, they calculate the concentration of MDA in a solution by its optical density at 532 nm, then these data are related with similar

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14

Bollenbach, Alexander, Svetlana Baskal, Catharina Mels, Ruan Kruger, and Dimitrios Tsikas. "Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine." Molecules 27, no. 16 (2022): 5202. http://dx.doi.org/10.3390/molecules27165202.

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Methylmalonic acid (MMA) is a very short dicarboxylic acid (methylpropanedioic acid; CH3CH(COOH)2; pKa1, 3.07; pKa2, 5.76) associated with vitamin B12 deficiency and many other patho-physiological conditions. In this work, we investigated several carboxylic groups-specific derivatization reactions and tested their utility for the quantitative analysis of MMA in human urine and plasma by gas chromatography-mass spectrometry (GC-MS). The most useful derivatization procedure was the reaction of unlabeled MMA (d0-MMA) and trideutero-methyl malonic acid (d3-MMA) with 2,3,4,5,6-pentafluorobenzyl bro

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15

Xi, Jianzhong, Miyong Yun, Duckgue Lee, et al. "Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling." Cellular Physiology and Biochemistry 35, no. 5 (2015): 1821–30. http://dx.doi.org/10.1159/000373993.

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Background/Aims: Our group reported that cinnamaldehyde derivative, (E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid (CB-PIC) induced apoptosis in hypoxic SW620 colorectal cancer cells via activation of AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase (ERK). Herein, sensitizing effect of CB-PIC was investigated in resistant cancer cells such as paclitaxel (PT) resistant lung cancer cells (H460/PT), and Adriamycin (Adr) resistant breast cancer (MCF7/Adr) and colon cancer (HCT15/cos) cells. Methods: Various drug resistant cell lines were treated with

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16

Alekseeva, G. M., V. F. Apraksin, and Yu E. Generalova. "EXPLORING OF ACID-BASIC PROPERTIES, DEVELOPMENT AND VALIDATION OF THE METHOD OF QUANTITATIVE DETERMINATION OF ORIGINAL PHARMACEUTICAL SUBSTANCE." Drug development & registration 8, no. 1 (2019): 66–71. http://dx.doi.org/10.33380/2305-2066-2019-8-1-66-71.

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Introduction. The object of analysis was a newly synthesized organic substance, a derivative of 4-aminobenzoic acid and malonic ester – 4,4’-(propandiamido) sodium dibenzoate, which has an antisteatotic effect. For the quantitative determination of pharmaceutical substances, it is preferable to use titrimetric methods of analysis, since they are absolute and allow us to estimate the content of the active compound in the substance without using standard samples. Aim. The objective of this work was to develop and validate a quantitative determination method for 4.4’-(propandiamido) sodium dibenz

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17

Focke, Manfred, and Hartmut K. Lichtenthaler. "Notes: Inhibition of the Acetyl-CoA Carboxylase of Barley Chloroplasts by Cycloxydim and Sethoxydim." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1361–63. http://dx.doi.org/10.1515/znc-1987-11-1240.

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The effect of the three cyclohexane-1,3-dione derivatives cycloxydim, sethoxydim and clethodim on the incorporation of 14C-labelled acetate, malonate. acctyl-CoA or malonyl-CoA into fatty acids was studied in an enzyme preparation isolated from barley chloroplasts (Hordeum vulgare L. var. “Alexis”). The herbicides cycloxydim, clethodim and sethoxydim block the de novo fatty acid biosynthesis from [2-14C]acetatc and [1-14C]acetyl-CoA, whereas that of [2-14C]malonatc and [2-14C)malonyl-CoA is not affected. The data indicate that the mode of action of the cyclohexane-1,3-dione derivatives in the

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18

Blaschette, Armand, Karin Linoh, Dietrich Koch та Ludger Ernst. "Polysulfonylamine, XV [1] Synthese von N,N,N′,N′-Tetramesyl-dicarbonsäurediamiden. Cyclisierung von N,N,N′,N′-Tetramesyl-bernsteinsäurediamid zu γ-DimesyIamino-Δβγ-butenolid / Polysulfonylamines, XV [1]. Synthesis of N,N,N′,N′-Tetramesyl Dicarboxylic Diamides. Cyclization of N,N,N′,N′-Tetramesyl Succinic Diamide to γ-Dimesylamino-Δβγ-butenolide". Zeitschrift für Naturforschung B 44, № 4 (1989): 465–74. http://dx.doi.org/10.1515/znb-1989-0415.

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N, N, N′, N′ -Tetramesyl dicarboxylic diamides Ms2NC(O)-Q-C(O)NMs2 [Q = (CH2)n with n = 0 (2a), 2 (2b), 3 (2c), 4 (2d); Q = o-phenylene (2e)] were prepared by reacting AgNMs2 (1) with the appropriate dicarboxylic dichlorides in acetonitrile at room temperature (2a, 2 c-2e) or at 0 °C (2b), respectively. Under similar conditions, malonic dichloride undergoes an elimination, forming AgCl, HNMs2 and probably polymeric C3O2. At 20 °C in CH3CN, the succinic acid derivative 2b eliminates one mole of HNMs2 and, by ring closure, yields γ-dimesylamino-Δβγ- butenolide (4a), the first example of a stable

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19

SHISHKIN, E. V., O. V. ANISHCHENKO, M. A. SHEVCHENKO, and A. V. CHERIKOV. "STEPWISE SYNTHESIS OF ACYLATED N-PHOSPHORYLATED MALONODIIMIDATES." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 5(288) (May 2024): 45–48. http://dx.doi.org/10.35211/1990-5297-2024-5-288-45-48.

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A stepwise synthesis of acylated N-phosphorylated malonodiimidates is proposed. N-phosphorylated malonic acid imidates were used as starting compounds. At the first stage of synthesis, sodium derivatives of N-phosphorylated imidates were obtained, at the second stage, the corresponding acylated compounds were obtained by interaction of sodium derivatives with acyl chloride. For acylated derivatives of N-phosphorylated malonic acid imidates, inhibition of acetylesterase, esterase hydrolase, kutinase, and other enzymes is predicted with high probability.

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20

Flisyuk, E. V., Ju M. Kotsur, I. A. Narkevich, I. E. Smekhova, and D. Yu Ivkin. "Development of the "Dissolution" Test Method for Tablets of Sodium 4,4'-(propanediamido)dibenzoate with Sustained Release." Drug development & registration 10, no. 4 (2021): 146–54. http://dx.doi.org/10.33380/2305-2066-2021-10-4(1)-146-154.

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Introduction. Non-alcoholic fatty liver disease is one of the most common chronic diseases of this parenchymal organ among the adult population. The search and creation of supporting drugs is an urgent task of modern pharmacy. The malonic acid derivative, sodium 4,4'-(propanediamido) dibenzoate, synthesized by the employees of the Department of Organic Chemistry of the SPСPU, has antisteatous activity, is a potential agent for the treatment of liver diseases. Sustained release tablets were prepared based on sodium 4,4'-(propanediamido)dibenzoate. An integral part of the pharmaceutical developm

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21

Melnykov, Sergii V., Andrii S. Pataman, Yurii V. Dmytriv, Svitlana V. Shishkina, Mykhailo V. Vovk, and Volodymyr A. Sukach. "Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones." Beilstein Journal of Organic Chemistry 13 (December 7, 2017): 2617–25. http://dx.doi.org/10.3762/bjoc.13.259.

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Background: Due to the high reactivity towards various C-nucleophiles, trifluoromethylketimines are known to be useful reagents for the synthesis of α-trifluoromethylated amine derivatives. However, decarboxylative reactions with malonic acid and its mono(thio)esters have been poorly investigated so far despite the potential to become a convenient route to β-trifluoromethyl-β-amino acid derivatives and to their partially saturated heterocyclic analogues. Results: In this paper we show that 4-trifluoromethylpyrimidin-2(1H)-ones, unique heterocyclic ketimines, react with malonic acid under organ

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22

Uriel, Clara, Rebeca Sola-Llano, Jorge Bañuelos, Ana Gomez, and J. Lopez. "A Malonyl-Based Scaffold for Conjugatable Multivalent Carbohydrate-BODIPY Presentations." Molecules 24, no. 11 (2019): 2050. http://dx.doi.org/10.3390/molecules24112050.

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A concise synthetic route from methylmalonate to a tetravalent aliphatic scaffold has been developed. The ensuing tetra-tethered derivative is equipped with two hydroxyl groups, as well as orthogonal alkene and alkyne functionalities. The usefulness of the scaffold has been demonstrated with the preparation of two representative multivalent derivatives: (i) a tetravalent compound containing two D-mannose units, one fluorescent boron-dipyrromethene (BODIPY) dye and a suitably functionalized amino acid and (ii) by way of dimerization and saponification, a water-soluble tetramannan derivative con

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23

Helavi, V. B., S. B. Solabannavar, U. V. Desai, and R. B. Mane. "MicrowavE Assisted hydrolysis of Meldrum'S Acid Derivatives and decarboxylation of Derived Malonic Acids." Journal of Chemical Research 2003, no. 3 (2003): 174–75. http://dx.doi.org/10.3184/030823403103173390.

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24

Venkatesan, Perumal, Subbiah Thamotharan, Rajendran Ganesh Kumar, and Andivelu Ilangovan. "Invariant and variable intermolecular interactions in functionalized malonic acid half-esters: X-ray, Hirshfeld surface and PIXEL energy analyses." CrystEngComm 17, no. 4 (2015): 904–15. http://dx.doi.org/10.1039/c4ce02125h.

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A series of functionalized malonic acid half-ester derivatives have been synthesized and their crystal structures are determined. Invariant and variable intermolecular interactions in these derivatives are analysed using Hirshfeld surfaces and PIXEL energy calculations.

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25

Çalış, Ihsan, S. Serap Birincioǧlu, Hasan Kırmızıbekmez, Bernhard Pfeiffer, and Jörg Heilmann. "Secondary Metabolites from Asphodelus aestivus." Zeitschrift für Naturforschung B 61, no. 10 (2006): 1304–10. http://dx.doi.org/10.1515/znb-2006-1019.

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Together with ten well known compounds, the quinic acid derivative chlorogenic acid, the nucleoside adenosine, two amino acids, tryptophan and phenylalanine, the anthraquinone derivatives, aloemodin, aloemodin acetate and chyrosphanol 1-O-gentiobioside, the flavon C-glycosides, isovitexin, isoorientin and isoorientin 4’-O-β -glucopyranoside, as well as two new acylated isoorientin derivatives, 6”-O-(malonyl)-isoorientin and 6”-O-[(S)-3-hydroxy-3-methylglutaroyl]-isoorientin, were isolated from the water soluble part of the methanolic extract of the fresh leaves of Asphodelus aestivus. All comp

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26

Sokov, S. A., K. V. Gordon, S. S. Zlotskii, and A. A. Golovanov. "Thiophenols Addition Reactions to Siliconcontaining Enynes and Enynones." Žurnal organičeskoj himii 60, no. 1 (2024): 109–19. https://doi.org/10.31857/s0514749224010106.

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As well as the cross-conjugated enynones, propynylidene derivatives of malonic ester and Meldrum’s acid that contain Me3Si, Et3Si and t-BuMe2Si groups, attach stereoselectively 4-methyl-, 4-methoxy- and 4-chlorothiophenol under conditions of base catalysis. In the process, there are sulfanilic compounds containing buta-1,3-diene and penta-1,4-dien-3-one fragments formed in high yields. In the thiylation products of the enyne derivatives of malonic ester and Meldrum’s acid, Me3Si, Et3Si and t-BuMe2Si groups are retained; desilylation occurs during the thiylation of 5-trialkylsilyl-1-phenylpent-

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27

Klopries, Stephan, Uschi Sundermann, and Frank Schulz. "Quantification ofN-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis." Beilstein Journal of Organic Chemistry 9 (April 5, 2013): 664–74. http://dx.doi.org/10.3762/bjoc.9.75.

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Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes. Individual malonic acid derivatives are typically required to be activated as coenzyme A-thioesters prior to their enzyme-catalyzed transfer onto the polyketide synthase. Control over the selection of malonic acid building blocks promises great potential for the experimental alteration of polyketide structure and bioactivity. One requirement for this endeavor is the supplem

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28

Urones, J. G., I. S. Marcos, L. Cubillo, V. A. Monje, J. M. Hernández, and P. Basabe. "Derivatives of malonic acid in Parentucellia latifolia." Phytochemistry 28, no. 2 (1989): 651–53. http://dx.doi.org/10.1016/0031-9422(89)80077-9.

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29

Ghochikyan, T. V., A. I. Martiryan, G. A. Shahinyan, et al. "Synthesis and Physicochemical Properties of Hydrazides of Malonic Acid with Different Substitutes." Eurasian Chemico-Technological Journal 26, no. 4 (2024): 203–9. https://doi.org/10.18321/ectj1644.

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Shown that the rout of reaction of 2-ethoxycarbonyl-4,4-disubstituted-4-butanolide with hydrazine hydrate at soft conditions (45─50 ᵒC) strongly depends on the substituents on position 2 of butanolide cycle. The effect of substituents on the mechanism of above-mentioned reaction and yields of products has been investigated. Obvious that, dihydrazides of substituted malonic acid are produced when R3=H, whereas in the case of alkyl substituted butanolides intramolecular cyclization of intermediate occurs at the same conditions and as a result 4,4-disubstituted pyrazolidine-3,5-diones are produce

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30

Takemoto, Yoshiji, Taryn March, Akihiro Murata та Yusuke Kobayashi. "Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction". Synlett 28, № 11 (2017): 1295–99. http://dx.doi.org/10.1055/s-0036-1588141.

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The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the β-hydroxy-α-amino acid derivatives in moderate to high yields and with high enantioselectivities.

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31

Journal, Baghdad Science. "Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings." Baghdad Science Journal 5, no. 3 (2008): 440–45. http://dx.doi.org/10.21123/bsj.5.3.440-445.

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In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finall

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32

Salih, Nadia Adil, and Hanan Abd El-Latif Ibraheem. "Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings." Baghdad Science Journal 5, no. 3 (2008): 440–45. http://dx.doi.org/10.21123/bsj.2008.5.3.440-445.

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In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finall

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33

Rudyanto, Marcellino, and Lanny Hartanti. "SYNTHESIS OF SOME CINNAMIC ACID DERIVATIVES: EFFECT OF GROUPS ATTACHED ON AROMATIC RING TO THE REACTIVITY OF BENZALDEHYDE." Indonesian Journal of Chemistry 8, no. 2 (2010): 226–30. http://dx.doi.org/10.22146/ijc.21626.

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Synthesis of cinnamic acid and its six derivatives has been done by employing Knoevenagel reaction. Benzaldehyde, 4-butylbenzaldehyde, 4-t-butylbenzaldehyde, 4-butoxybenzaldehyde, 4-phenylbenzaldehyde, 5-bromo-2,4-dimethoxybenzaldehyde, and 5-bromo-2,3-dimethoxybenzaldehyde were reacted with malonic acid in pyridine – piperidine to give cinnamic acid (85,3%), 4-butylcinnamic acid (69,3%), 4-t-butylcinnamic acid (77,7%), 4-butoxycinnamic acid (64,5%), 4-phenylcinnamic acid (65,5%), 5-bromo-2,4-dimethoxycinnamic acid (53,2%) and 5-bromo-2,4-dimethoxycinnamic acid (57,2%), respectively. It was di

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34

Toepfer, Alexander, Gerhard Kretzschmar, Silke Schuth, and Michael Sonnentag. "MALONIC ACID DERIVATIVES AS SIALYL LEWIS X MIMETICS." Bioorganic & Medicinal Chemistry Letters 7, no. 10 (1997): 1317–22. http://dx.doi.org/10.1016/s0960-894x(97)00214-x.

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35

Shekhadeh, A., N. G. Didkovskii, A. V. Dogadina, and B. I. Ionin. "Reaction of Malonic Acid Derivatives with Acetylenic Diphosphonates." Russian Journal of General Chemistry 75, no. 1 (2005): 9–17. http://dx.doi.org/10.1007/s11176-005-0163-8.

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36

GENKINA, N. K., V. V. IPATKIN, and L. N. KURKOVSKAYA. "ChemInform Abstract: Malonic Acid Derivatives for Pyridazine Synthesis." ChemInform 23, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.199201193.

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37

Elinson, Michail N., Anatoly N. Vereshchagin, Yuliya E. Anisina, Stepan K. Krymov, Artem N. Fakhrutdinov, and Mikhail P. Egorov. "Multicomponent assembling of salicylaldehydes, kojic acid and malonic acid derivatives." Mendeleev Communications 29, no. 5 (2019): 581–83. http://dx.doi.org/10.1016/j.mencom.2019.09.035.

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38

Shaima Ibrahim Chyad Al-khazraji and Khalid M. Mohammed Al-janabi. "Synthesis and characterization heterocyclic of compounds derived fromamino pyridine substituted." Tikrit Journal of Pure Science 21, no. 2 (2023): 63–79. http://dx.doi.org/10.25130/tjps.v21i2.974.

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In this study, heterocyclic derivatives of imidazole, pyrimidine, benzodiazepine, indole and benzimidazole were synthesized. These new compounds were formed through the condensation reaction between 2-aminopyridinederivative with4-phenylphenacyl bromide, chloroacetic acid, malonic acid, phthalic acid, isatin and o-phenylenediamine respectively. All of these compounds synthesized produced of good yield percentage, The synthesized compounds structures were characterized by FTIR, 1H- and 13C-NMR spectroscopy

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39

Šafář, Peter, František Považanec, Pavel Čepec, and Naďa Prónayová. "Preparation of Derivatives of 2-Cyano-3-(5-N-arylamino- or 5-N-Alkyl-N-phenylamino-2-furyl)propenoic Acids." Collection of Czechoslovak Chemical Communications 62, no. 7 (1997): 1105–13. http://dx.doi.org/10.1135/cccc19971105.

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(5-Bromo-2-furyl)methylidenemalonodinitrile (1) reacted with substituted aromatic amines under formation of (5-N-arylamino-2-furyl)methylidenemalonodinitriles 2a-2h whereas no reaction was observed with N-alkyl-N-phenylamines. Derivatives of 2-cyano-3-(5-N-alkyl-N-phenylamino-2-furyl)- propenoic acid 5a-5o were prepared by reaction of the corresponding N-alkylanilines with 5-bromo-2-furancarbaldehyde, followed by hydrolysis of the obtained Eiji salts and reaction with malonic acid derivatives.

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40

Mohareb, Rafat M., Sherif M. Sherif, Adiba Habashi, Nadia I. Abdel-Sayed, and Samia S. Osman. "Reaction of Carbon Disulfide with Active Methylenes: Novel Synthesis of Thiophene, Thieno[2,3-b]thiophene, Thieno[3,2-c]pyrazole and Thieno[3,2-b]pyridine Derivatives." Collection of Czechoslovak Chemical Communications 60, no. 9 (1995): 1578–86. http://dx.doi.org/10.1135/cccc19951578.

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The active methylene compounds - derivatives of malonic or 4-oxobutanoic acid - reacted with carbon disulfide in dimethyl formamide containing potassium hydroxide to yield the non-isolable dipotassium disulfide intermediates. The latter were cyclized by α-haloketones to give thiophene, thieno[2,3-b]thiophene, thieno[3,2-c]pyrazole and thieno[3,2-b]pyridine derivatives. The reactivity of the products toward various reagents was studied.

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41

Finta, Zoltán, Zoltán Hell, Agnieszka Cwik, and László Tőke. "A Simple Synthesis of 1,1,2-tris-(Hydroxymethyl)-Cyclopropane and Its Dihalo Derivatives." Journal of Chemical Research 2002, no. 9 (2002): 459–60. http://dx.doi.org/10.3184/030823402103172653.

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The phase transfer catalytic cyclopropanation of the malonic ester of allylic alcohol or its 3,3-dibromo and 3,3-dichloro derivatives yields bicyclic cyclopropane carboxylic acid lactones; reduction of these lactones with LiAlH4 in boiling THF yields the appropriate 1,1,2-tris-(hydroxymethyl)cyclopropanes in satisfactory yield.

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42

Petrov, A. V., K. N. Semenov, and I. V. Murin. "Electronic Structure of Fullerene Derivatives with Malonic Acid Fragments." Russian Journal of General Chemistry 88, no. 3 (2018): 610–12. http://dx.doi.org/10.1134/s1070363218030374.

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43

Krumme, Dirk, and Harald Tschesche. "Synthesis and reduction of endothiodipeptides containing malonic acid derivatives." Tetrahedron 55, no. 10 (1999): 3007–18. http://dx.doi.org/10.1016/s0040-4020(99)00084-8.

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44

Koleda, Olesja, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, and Edgars Suna. "Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters." Beilstein Journal of Organic Chemistry 21 (March 19, 2025): 630–38. https://doi.org/10.3762/bjoc.21.50.

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The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides access to N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.

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Bauwens, Matthias, Marijke De Saint-Hubert, Jan Cleynhens, et al. "Radioiodinated Phenylalkyl Malonic Acid Derivatives as pH-Sensitive SPECT Tracers." PLoS ONE 7, no. 6 (2012): e38428. http://dx.doi.org/10.1371/journal.pone.0038428.

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46

Lafrance, Danny, Paul Bowles, Kyle Leeman, and Robert Rafka. "Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole." Organic Letters 13, no. 9 (2011): 2322–25. http://dx.doi.org/10.1021/ol200575c.

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47

TOEPFER, A., G. KRETZSCHMAR, S. SCHUTH, and M. SONNENTAG. "ChemInform Abstract: Malonic Acid Derivatives as Sialyl Lewis X Mimetics." ChemInform 28, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199739251.

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48

Ma, Chao-Mei, Xiu-Hong Wu, Masao Hattori, Xi-Jun Wang, and Yoshihiro Kano. "HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 3 (2009): 243. http://dx.doi.org/10.18433/j3dw2d.

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Purpose: To evaluate oleanolic acid derivatives on liver disease related bioactivities, 29 oleanolic acid derivatives of several series were tested for their inhibitory activity on hepatitis C viral protease and for their cytotoxic effects on Hep G2 cells. Results: The amino derivatives showed potent cytotoxicity, among which, the beta-amino isomer exhibited more distinct cytotoxicity than the alpha-isomer. The cytotoxicity of hemiesters and hemiamides varied as the chain lengths varied. The oxalic and malonic hemiesters showed weaker cytototoxicity than oleanolic acid, while those with longer

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49

Cheng, He-Li, Xian-Hui Xie, Jia-Zheng Chen, Zhen Wang, and Jian-Ping Chen. "An in situ masking strategy enables radical monodecarboxylative C–C bond coupling of malonic acid derivatives." Chemical Science 12, no. 35 (2021): 11786–92. http://dx.doi.org/10.1039/d1sc02642a.

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An in situ masking strategy has been developed based upon the unique properties of silver catalysts to successfully achieve a radical monodecarboxylative C–C bond coupling of malonic acids with ethynylbenziodoxolone reagents.

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50

Artis, Dean R., In-Seop Cho, and Joseph M. Muchowski. "Radical-based syntheses of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (ketorolac)." Canadian Journal of Chemistry 70, no. 6 (1992): 1838–42. http://dx.doi.org/10.1139/v92-228.

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Short, efficient, and convergent syntheses of ketorolac (1) based on the inter- or intramolecular oxidative addition of malonyl and substituted malonyl radicals to 2-benzoylpyrrole and derivatives thereof are described.

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