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Relevant bibliographies by topics / Mammalian genomics / Dissertations / Theses

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Dissertations / Theses on the topic 'Mammalian genomics'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Mikkelsen, Tarjei Sigurd 1978. "Mammalian comparative genomics and epigenomics." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/52808.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>The human genome sequence can be thought of as an instruction manual for our species, written and rewritten over more than a billion of years of evolution. Taking a complete inventory of our genome, dissecting its genes and their functional components, and elucidating

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2

Kiritsy, Michael C. "Functional Genomics of Mammalian Innate Immunity." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1102.

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The breadth of genetic diversity in the mammalian immune response stands out amongst the ubiquity of variation seen in the genome, evidence that microbial infections have been a major driver of evolution. As technology has facilitated an understanding of the etiology of immunological diversity, so too has it enabled the assessment of its varied functions. Functional genomics, with its ability to assess both cause and effect, has revolutionized our understanding of fundamental biological phenomena and recalibrated our hypotheses. We build upon the model of host immunity established by rare gene

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3

Villanueva, Cañas José Luis 1984. "Insights into mammalian adaptive evolution through genomics data." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/397756.

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Although the genome sequencing revolution is still in its infancy, we must acknowledge it as the major driver of biology since the beginning of the 21st century. The availability of a large collection of complete mammalian genomes due to high-throughput sequencing technologies allows us to begin the exploration of how the evolutionary diversification of gene content reflects the ecological adaptations of different taxa. Novelty arises in evolution through the transformation or combination of existing systems and, as shown recently, also from scratch. This thesis is centered around these differ

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4

Cheung, Hiu Tung (Tom). "Understanding mammalian transcriptional regulation using comparative and functional genomics." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3207751.

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5

Jordan, Gregory. "Analysis of alignment error and sitewise constraint in mammalian comparative genomics." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610693.

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6

Ratcliffe, Sarah. "Identification of a silicon-responsive gene in the mammalian genome." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610011.

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7

Siepel, Adam C. "Comparative mammalian genomics : models of evolution and detection of functional elements /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.

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8

Hsiao, Albert. "Comparative functional genomics of energy metabolism and insulin resistance in mammalian systems." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3165076.

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Thesis (Ph.D.)--University of California, San Diego, 2005.<br>Title from p. 1 of PDF file (viewed October 21, 2005) Vita. Includes bibliographical references (p. 170-175 ). Available online via UMI ProQuest Digital Dissertations.

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9

Saini, Harleen. "Intron and Small RNA Localization in Mammalian Neurons." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1044.

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RNA molecules are diverse in form and function. They include messenger RNAs (mRNAs) that are templates for proteins, splice products such as introns that can generate functional noncoding RNAs, and a slew of smaller RNAs such as transfer RNAs (tRNAs) that help decode mRNAs into proteins. RNAs can show distinct patterns of subcellular localization that play an important role in protein localization. However, RNA distribution in cells is incompletely understood, with prior studies focusing primarily on RNAs that are long (>200 nucleotides), fully processed, and polyadenylated. We examined the di

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10

Endo, Yoshinori. "Comparative study of mammalian evolution by genomic analyses and pluripotent stem cell technology." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263514.

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11

Chaisson, Mark. "Combinatorial methods in computational genomics mammalian phylogenetics using microinversions and fragment assembly with short reads /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3337222.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed February 6, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 151-161).

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12

Rands, Chris M. D. "Analyses of functional sequence in mammalian and avian genomes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:27e0ac20-eb27-423c-9493-a8a1c6cc57b8.

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The first draft sequence of the human genome was published over a decade ago, yet interpreting the functional importance of nucleotides in genomes is still an ongoing challenge. I took a comparative genomic approach to identify functional sequence using signatures of natural selection in DNA sequences. Mutations that are purged or propagated by selection mark sequences of significance for biological fitness. I developed and refined methods for estimating the quantity of sequence constrained with respect to insertions and deletions (indels) between two genome sequences, a quantity I termed α<su

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13

Broderick, Jennifer A. "Cooperativity in Mammalian RNA Silencing: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/548.

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Argonaute proteins are the core component of an RNA silencing complex. The human genome encodes four Argonaute paralogs –Ago1, Ago2, Ago3 and Ago4– proteins that are guided to target mRNAs by microRNAs. More than 500 miRNAs are conserved between mammals, and each microRNA can repress hundreds of genes, regulating almost every cellular process. We still do not fully understand the molecular mechanisms by which miRNAs regulate gene expression. Although we understand many aspects of microRNA biogenesis and formation of the RNA-induced silencing complex, much less is known about the subsequent ste

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14

Palace, Samantha G. "Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/836.

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Yersinia pestis, the causative agent of plague, specializes in causing dense bacteremia following intradermal deposition of a small number of bacteria by the bite of an infected flea. This robust invasiveness requires the ability to evade containment by the innate immune system. Of the various mechanisms employed by Y. pestis to subvert the innate immune response and to proliferate rapidly in mammalian tissue, only a few are well-characterized. Here, I present two complementary genetic analyses of Y. pestis adaptations to the mammalian environment. In the first, genome-wide fitness profiling f

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15

Yau, Christopher. "Statistical methodologies for the identification of copy number variation in mammalian genomes from high-throughput genomic datasets." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504339.

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16

Laurie, Steven 1973. "Mutation, duplication, and selection in mammalian genomes." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/120514.

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This thesis comprises comparative genomics analyses primarily focussing on the evolution of mammalian proteins. We concentrate on three species of direct relevance as model organisms, for which high quality genome sequences are available, and human. Having previously investigated protein evolution in terms of substitution rates, here we explored less well studied insertions and deletions (indels). We show that indel and substitution frequencies are correlated at the level of protein sequence, and that indels, and in particular insertions, are elevated in regions of low-complexity and repetitiv

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17

Castillo, Morales Atahualpa. "Genomic signatures of neurodegeneration and the evolution of mammalian brain." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675727.

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Due to the complex adaptive costs and benefits of large brains and large neocortical volume, mammalian species exhibit huge variation in brain size. However, the precise nature of the genomic changes accounting for these variations remains poorly understood. Using genome-wide comparative analysis of gene family size of more than 39 fully sequenced mammalian species, I studied whether changes in the number of copies of genes involved in distinct cellular and developmental functions has contributed to shaping the morphological, physiological and metabolic machinery supporting brain evolution in

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18

Prakash, Ashwin. "Evolution and Function of Compositional Patterns in Mammalian Genomes." THE UNIVERSITY OF TOLEDO, 2012. http://pqdtopen.proquest.com/#viewpdf?dispub=3490731.

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19

Ward, Michelle Claire. "The regulatory potential of repetitive elements in mammalian genomes." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648276.

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20

Lin, Michael F. (Michael Fong-Jay). "Comparative gene identification in mammalian, fly, and fungal genomes." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36807.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.<br>Includes bibliographical references (leaves 55-56).<br>An important step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that have been conserved by natural selection over millions of years of evolution. I develop general computational methods that combine statistical analysis of genome sequence alignments with classification al

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21

Prakash, Ashwin. "Evolution and Function of Compositional Patterns in Mammalian Genomes." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1321301839.

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22

Aitken, Sarah Jane. "The pathological and genomic impact of CTCF depletion in mammalian model systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284403.

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CCCTC-binding factor (CTCF) binds DNA, thereby helping to partition the mammalian genome into discrete structural and regulatory domains. In doing so, it insulates chromatin and fine-tunes gene activation, repression, and silencing. Complete removal of CTCF from mammalian cells causes catastrophic genomic dysregulation, most likely due to widespread collapse of 3D chromatin looping within the nucleus. In contrast, Ctcf hemizygous mice with lifelong reduction in CTCF expression are viable but have an increased incidence of spontaneous multi-lineage malignancies. In addition, CTCF is mutated in

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23

Clément, Yves [Verfasser]. "The evolution of base composition in mammalian genomes / Yves Clément." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1030488088/34.

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24

Vamathevan, J. J. "Evolutionary analysis of mammalian genomes and associations to human disease." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/14733/.

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Statistical models of DNA sequence evolution for analysing protein-coding genes can be used to estimate rates of molecular evolution and to detect signals of natural selection. Genes that have undergone positive selection during evolution are indicative of functional adaptations that drive species differences. Genes that underwent positive selection during the evolution of humans and four mammals used to model human diseases (mouse, rat, chimpanzee and dog) were identified, using maximum likelihood methods. I show that genes under positive selection during human evolution are implicated in dis

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25

Raj, Towfique. "Molecular signatures of natural and artificial selection in mammalian genomes." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609021.

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26

Hodges, Emily Carol. "High resolution genomic tools for the discovery of protein function in mammalian cells /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-775-8/.

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27

Holtom, Benjamin J. "A Paralogy Based Strategy for Identifying Regulatory Elements in Mammalian Genomes." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487255.

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The massive advancements in genomics over recent years has not only provided scope to examine what is shared between the genomes of multiple species but also a unique opportunity to investigate that which is responsible for the differences between species of interest. By comparing the proteomes of two species, certain genes can be' clustered and defined as 'inparalogs' - duplicated genes which are respectively unique to each of the species in question having arisen at a time-point subsequent to the speciation event that separated the two lineages in question. Here I report on several analyses

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28

Down, T. "Computational localization of promoters and transcription start sites in mammalian genomes." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598623.

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Here, I investigate the question of identifying and annotating promoters, one of the most important regulatory signals in the genome, which mark the points where transcription is initiated, and regulate the transcription of genes. I present a new computational method, EponineTSS, which can predict transcription start sites in bulk genomic sequence data with excellent sensitivity and specificity. Unlike the existing methods, it gives an indication of the actual location of the transcription start site. Comparisons with available experimental data suggest that the positional accuracy of these pr

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29

Sanna, Chaitanya Ramesh. "Patterns of Two Types of Overlapping Genes in Five Mammalian Genomes." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/43601.

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Increasing evidence suggests that overlapping genes is a common phenomenon in eukaryotic genomes too and are not restricted to prokaryotes alone. Here we determined overlapping genes in a set of orthologous genes in the genomes of human, chimp, mouse, rat, and dog and contrasted the patterns of overlapping between two principal types of overlapping genes, the same-strand-overlapping genes and different-strand-overlapping genes. The two types of overlapping genes are compared with respect to their frequencies, overlap lengths, region of overlap, and conservation of overlap in five species. Our

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30

Xu, Xiufeng. "Studies of mammalian mitochondrial genomes with special emphasis on the perissodactyla." Lund : Lund University, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38161173.html.

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31

Krämer, Dorothee Charlotte Agathe. "Investigation of Mammalian Chromatin Folding at Different Genomic Length Scales using High Resolution Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19929.

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Chromatin ist ein Makromolekül, dessen Genregulation innerhalb des räumlich eingeschränkten Zellkerns organisiert werden muss. Die Genomorganisation ist eng mit Genaktivierung und Genrepression verknüpft. In den vergangenen Jahren wurde gezeigt, dass die DNA hierarchisch organisiert ist. Die Faltung läuft in aufeinander folgenden Schritten ab, wobei jede Organisationsebene sowohl zur räumlichen Komprimierung, als auch zur Genregulation beiträgt. In dieser Dissertation wurden mit Hilfe von hochauflösender Mikroskopie verschiedene Ebenen der 3D Chromatinorganisation auf Einzelzell-Basis untersuc

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32

Lee, Adam. "The in silico identification and analysis of ancient and recent endogenous retroviruses in mammalian genomes." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/39972.

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Recent advances in DNA sequencing technologies have led to a vast plethora of vertebrate genomes being made available for bioinformatic analysis and investigation. This has presented retrovirologists with many new opportunities to study endogenous retroviruses (ERVs) - selfish genetic element (SGEs) endogenised within the genomic DNA of their hosts. Many of these ERVs exist as molecular fossils of past germline infections by their exogenous counterparts, representing approximately 8-10% of mammalian genomes. While the majority are thought to be inactive today, one particular retroviral group -

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33

Pelletier, Richard. "Functional genomic mapping of a centromeric mammalian origin of DNA replication and identification of its minimal functional sequence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0021/NQ44551.pdf.

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34

Pelletier, Richard. "Functional genomic mapping of a centromeric mammalian origin of DNA replication and identification of its minimal functional sequence." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35043.

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The nature of origins of DNA replication in mammalians has yet to be elucidated. The localization of the initiation sites and the identification of the corresponding sequences and/or structures is important to understand the process of initiation at the molecular level. The objective of the research in this thesis is to localize the initiation site of DNA synthesis at a specific locus on the chromosomes of mammalian cells, and to characterize the minimal sequence requirements for the function of this origin of DNA replication in vivo. A genomic clone was isolated using ors12, a mammalian auton

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35

Tsurkan, Sarah [Verfasser], A. Francis [Gutachter] Stewart, and Yixin [Gutachter] Zhang. "Designer Nuclease-Assisted Targeting to Engineer Mammalian Genomes / Sarah Tsurkan ; Gutachter: A. Francis Stewart, Yixin Zhang." Dresden : Technische Universität Dresden, 2018. http://d-nb.info/1226895824/34.

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36

Caddy, Joanne. "The non-genomic effects of the PPAR-γ ligand rosiglitazone on intracellular calcium concentrations in mammalian monocytic and smooth muscle cells". Thesis, Cardiff Metropolitan University, 2010. http://hdl.handle.net/10369/921.

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Thiazolidinediones such as rosiglitazone are used in the treatment of Type-2 Diabetes, and are ligands for peroxisome proliferator-activated receptor-gamma (PPARγ), a ligand-activated transcription factor that regulates expression of genes involved in glucose and lipid metabolism. However, rosiglitazone is known to exert PPARγ-independent effects alongside its classical receptor-dependent effects. This study investigated the PPARγ-independent effects of rosiglitazone on intracellular calcium (Ca2+i) signalling in cultured monocytic and vascular smooth muscle cells Rosiglitazone rapidly (5-30mi

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37

Mahmood, M. "The physiological actions and cellular signaling pathways mediating the acute non-genomic effects of DHT in isolated intact mammalian skeletal muscle fibre bundles." Thesis, University of East Anglia, 2011. https://ueaeprints.uea.ac.uk/34306/.

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38

Soh, Ying Qi Shirleen. "The genomic and genetic basis of mammalian sexual reproduction : sequence of the mouse Y chromosome, and a gene regulatory program for meiotic prophase." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98632.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Mammalian sexual reproduction requires sexual determination, sexual differentiation, and the production of haploid gametes. In this thesis, I examined the genomic evolution of the mouse Y chromosome, which instructs sexual determination, and genetic regulation of a program of gene expression for meiosis, a specialized cell cycle which gives rise to haploid gametes. Chapter 2 describes the study of the mouse Y chromosome. Contrar

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39

Krämer, Dorothee Charlotte Agathe [Verfasser], Ana [Gutachter] Pombo, Petra [Gutachter] Knaus, and Markus [Gutachter] Landthaler. "Investigation of Mammalian Chromatin Folding at Different Genomic Length Scales using High Resolution Imaging / Dorothee Charlotte Agathe Krämer ; Gutachter: Ana Pombo, Petra Knaus, Markus Landthaler." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1189145944/34.

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40

Krämer, Dorothee [Verfasser], Ana [Gutachter] Pombo, Petra [Gutachter] Knaus, and Markus [Gutachter] Landthaler. "Investigation of Mammalian Chromatin Folding at Different Genomic Length Scales using High Resolution Imaging / Dorothee Charlotte Agathe Krämer ; Gutachter: Ana Pombo, Petra Knaus, Markus Landthaler." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1189145944/34.

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41

Rein, Katrin 1983. "The MRE11 complex and EX01 collaborate to support mammalian development and the cellular responses to DNA damage." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/384236.

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The maintenance of genome stability is crucial for homeostasis, development and suppression of diverse pathologies that include developmental disorders, premature aging and cancer. The DNA damage response coordinates the appropriate cellular responses following the detection of lesions to prevent genomic instability. The MRE11 complex is a sensor of DNA double strand breaks and plays key roles in multiple aspects of the DNA damage signaling, including the initiation of DNA end resection that is critical for the accurate break repair and the replication fork maintenance. Many studies have impli

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42

Goulas, Jordane. "Regulation of the DNA polymerase zeta in response to genotoxic stress in mammalian cells." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASL003.

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Lors de la réplication, la présence de lésions sur l'ADN représente un obstacle pour les polymérases réplicatives. Cela peut conduire à des cassures doubles brin et à une instabilité génomique. Pour éviter de telles conséquences, les cellules ont développé des voies de tolérance aux dommages. Parmi elles, la synthèse translésionnelle (TLS) fait appel à des polymérases spécialisées très peu fidèles capables de franchir ces dommages, permettant ainsi de poursuivre la réplication et de favoriser la survie cellulaire, au prix d'une augmentation des mutations dans le génome. La TLS contribue donc a

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Xu, Meng. "Specialised transcription factories." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:a41d3243-c233-491a-916b-4e329cace434.

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The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to be answered in order to fit all the pieces of the jigsaw together. The underlying mechanisms, precisely

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Buckley, Reuben Mackenzie. "Evolution of mammalian genome architecture through retrotransposition." Thesis, 2017. http://hdl.handle.net/2440/119371.

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Retrotransposons, mobile DNA elements that replicate via a copy and paste mechanism, are a major component of mammalian genome architecture. They account for at least one-third of the human genome and are major drivers of lineage-specific gain and loss of DNA. While there are many examples of how specific retrotransposons have impacted evolution, their interaction with large-scale genome architecture remains poorly characterised. Throughout my thesis I investigated two fundamental questions regarding genome evolution and retrotransposons. Firstly, how does genome architecture shape retrotransp

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Munger, Steven Carmen. "A systems-level view of mammalian sex determination." Diss., 2010. http://hdl.handle.net/10161/3006.

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<p>Pathologies of sexual development are common in humans and reflect the precarious processes of sex determination and sexual differentiation. The gonad forms as a bipotential organ, and recent results from the Capel lab revealed that it is initially balanced between testis and ovarian fates by opposing and antagonistic signaling networks. In XY embryos, this balance is disrupted by the transient expression of the Y-linked gene, Sry, which activates genes that promote the testis pathway and oppose the ovarian pathway. While the roles of a few genes have been defined by mutation, current evide

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"Life History Affects Cancer Gene Copy Numbers in Mammalian Genomes." Master's thesis, 2019. http://hdl.handle.net/2286/R.I.55516.

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abstract: Cancer is a disease which can affect all animals across the tree of life. Certain species have undergone natural selection to reduce or prevent cancer. Mechanisms to block cancer may include, among others, a species possessing additional paralogues of tumor suppressor genes, or decreasing the number of oncogenes within their genome. To understand cancer prevention patterns across species, I developed a bioinformatic pipeline to identify copies of 545 known tumor suppressor genes and oncogenes across 63 species of mammals. I used phylogenetic regressions to test for associations betwe

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Natarajan, Anirudh. "Uncovering the Transcription Factor Network Underlying Mammalian Sex Determination." Diss., 2014. http://hdl.handle.net/10161/8746.

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<p>Understanding transcriptional regulation in development and disease is one of the central questions in modern biology. The current working model is that Transcription Factors (TFs) combinatorially bind to specific regions of the genome and drive the expression of groups of genes in a cell-type specific fashion. In organisms with large genomes, particularly mammals, TFs bind to enhancer regions that are often several kilobases away from the genes they regulate, which makes identifying the regulators of gene expression difficult. In order to overcome these obstacles and uncover transcriptiona

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48

El-Mogharbel, Nisrine Abdul Karim. "Evolution of mammalian XY sex chromosomes from a bird-like ZW system." Phd thesis, 2008. http://hdl.handle.net/1885/150481.

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Badve, Abhijit. "Discovery and evolutionary dynamics of RBPs and circular RNAs in mammalian transcriptomes." Thesis, 2015. http://hdl.handle.net/1805/7820.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>RNA-binding proteins (RBPs) are vital post-transcriptional regulatory molecules in transcriptome of mammalian species. It necessitates studying their expression dynamics to extract how post-transcriptional networks work in various mammalian tissues. RNA binding proteins (RBPs) play important roles in controlling the post-transcriptional fate of RNA molecules, yet their evolutionary dynamics remains largely unknown. As expression profiles of genes encoding for RBPs can yield insights about their evolutionary trajectories on the post-t

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Mwangi, Sarah Wambui. "An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host." Thesis, 2009. http://hdl.handle.net/11394/3407.

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>Magister Scientiae - MSc<br>Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk in sub-Saharan Africa and up to 50,000 deaths per year caused by trypanosomiasis. Current management of human African trypanosomiasis relies on active surveillance and chemotherapy of infected patients. Efforts to develop a vaccine to immunize the human host have been hampered by antigenic variation of the parasites cell coat. The advent of the

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