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Dissertations / Theses on the topic 'Materia media, Vegetable – South Africa'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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1

Wilson, Gayle Pamela. "Optimisation of an in vitro model for anti-diabetic screening." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/428.

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The need for alternative strategies for the prevention and treatment of diabetes is growing rapidly as type II diabetes is reaching epidemic status in our society. This need was the basis for the creation of this study, as it was necessary to start looking towards medicinal plants as potential antidiabetic treatment and no comprehensive in vitro model existed. In creating a model for determining the effects of alternative traditional medicines as antidiabetic potentiates, it was necessary that two metabolic pathways, namely glucose uptake and insulin secretion, which play a significant role in
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2

Bosch, Janine. "Production of biologically active recombinant HIV-1 protease and intehrase for the purpose of screening medicianl plant extracts." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1056.

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Human immunodeficiency virus (HIV) and its gradual weakening of the immune system is an ever growing threat. Acquired immune deficiency syndrome (AIDS), the final stage of HIV, renders a person vulnerable to various opportunistic infections, which in the end lead to death. Apart from intensive vaccine studies, treatment research mainly focuses on preventing the individual HIV enzymes (reverse transcriptase, integrase and protease) from performing their functions. Entry inhibitors, however, block viral entry into the cell, while antisense drugs lock onto the viral genome to keep it from functio
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3

Harnett, Siobhán Margaret. "In vitro anti-HIV activities of Sutherlandia frutescens and Lobostemon trigonum extracts." Thesis, University of Port Elizabeth, 2004. http://hdl.handle.net/10948/347.

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Currently, the approved anti-HIV drugs on the market only target the three HIV enzymes: reverse transcriptase, protease and more recently, integrase. Due to the limited nature of the current therapy, it is possible that a multi-drug resistant virus can emerge. The main concerns in developing countries however, are the expense and availability of the drugs and because of this, it is essential to investigate all alternatives. Traditional medicine offers many advantages as compared to allopathic treatment in so far as being relatively cheaper, accessible and it is broadly accepted in the populati
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4

Kabatende, Joseph. "Pharmacological evaluation of some central nervous system effects of Cotyledon Orbiculata." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The use of traditional medicine through the use of medicinal plants in Africa and especially in South Africa has long been considered an important characteristic of people's daily lives and socio-cultural heritage. Cotyledon Orbiculata is among the medicinal plants that are used by South African traditional practitioners for the treatment of epilepsy and painful conditions such as corns, warts, toothache, earache, boils and various other ailments. However, the claim of therapeutic successes of medicinal plants by traditional medicine practitioners are hardly subjected to scientific scrutiny. T
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5

Mohlakoana, Keneuoe. "Antimicrobial activity of selected Eastern Cape medical plants." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1199.

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Bacterial resistance to antibiotics has been a great problem for many years. The degree of resistance and the speed with which resistance develops varies with different organisms and different drugs. Enzymes called β-lactamases are produced by bacteria and are one mechanism in which bacteria develop antimicrobial resistance. Gram-negative bacteria producing enzymes called ESBLs because of their wide substrate range are of a particular concern in nosocomial infections. In many countries people still use traditional medicine derived from plants as an alternative to the Western medicine due to in
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6

Muwanga, Catherine. "An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3303_1184589097.

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<p>In South Africa, the crude aqueous extract from Hypoxis hemerocallidea is used by AIDS patients to treat opportunistic infections, such as tuberculosis. The rapid emergence of multidrug-resistant tuberculosis, and extreme drug resistant tuberculosis, in recent years, is a major threat to human health. The treatment of TB, nosocomial bacterial infections, and fungal infections is now a clinical challenge, especially in the immuno-compromised individual. There is a dire need for novel antibiotic alternatives with phytotherapies and plant-derived compounds as potentially promising alternatives
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7

Mnonopi, Nandipha Olivia. "In vitro testing to investigate the anticoagulant/antithrombotic and antidiabetic biological activity of Leonotis Leonurus." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/693.

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The rising costs of prescription drugs in the maintenance of personal health and wellbeing have increased the interest in medicinal plants. The World Health Organization estimates that 65 percent-80 percent of the world’s population use traditional medicine as their primary form of health care. In this project the focus has been on the use of Leonotis leonurus extracts as a traditional medicine. The major chemical constituent of this plant is marrubiin, which is a diterpenoid labdane lactone formed from a precursor called premarrubiin. Aqueous and acetone extract (AL and OL extract, respective
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8

Williams, Samantha. "Socio-economic aspects of the sustainable harvesting of buchu (Agathosma Betulina) with particular emphasis on the Elandskloof community." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The aim of this thesis was to explore the socio-economic factors that impact on the sustainable harvesting of buchu in the Western Cape of South Africa. Some of the factors that were explored include poverty, natural resource tenure, legislation, and local practices with regard to the harvesting of buchu.
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9

Mnonopi, Nandipha. "Leonotis leonurus: the anticoagulant and antidiabetic activity of Leonotis leonurus." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1194.

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Commercial marrubiin, aqueous and organic extracts of Leonotis leonurus were tested in vitro for their anticoagulant and antiplatelet activities. The aqueous extract inhibited platelet aggregation by 69.5 percent (100 μg/mL), while the organic extract (100 μg/mL) and marrubiin (5 μg/mL) showed 92.5 percent and 91.6 percent inhibition, respectively, by inhibiting the binding of fibrinogen to glycoprotein IIb/IIIa receptor in a concentration dependent manner. The extracts significantly prolonged activated partial thromboplastin time compared to untreated plasma controls. Fibrin and D-Dimer forma
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10

Van, Gend Tania Anli. "Effect of a South African medicinal plant on antiretroviral drug induced abnormalities in rats." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/1080.

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The worldwide AIDS epidemic is known to have had a profoundly negative social, economic and personal impact and has taken a heavy toll on existing health care systems, particularly in developing countries. South Africa is experiencing an HIV epidemic with enormous social and economic consequences. Lopinavir/ritonavir antiretroviral treatment has been accredited with having a significantly positive effect and is a key advance in controlling HIV morbidity and mortality. An indigenous South African medicinal plant, Sutherlandia frutescens, known for its anti-diabetic properties and immune-boostin
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11

Fang, Yuan Yuan. "In vitro drug-herb interaction potential of African medicinal plant products used by Type II diabetics." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1341.

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In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and
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12

Chinyama, Robert Fred. "Biological activities of medicinal plants traditionally used to treat Septicaemia in the Eastern Cape, South Africa." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1274.

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Over the past 25 years, there has been a resurgence of worldwide scientific research in the fields of ethnopharmacology. The Western world has acknowledged the continued use of traditional medicines by the majority of third world countries, and the need for novel drug development. Hence, much of the pharmaceutical research in recent years has focused on the ethnobotanical approach to drug discovery (Light et al., 2005). In South Africa, as in most developing parts of the world, traditional herbal medicine still forms the backbone of rural healthcare. The government health services in South Afr
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13

Monakisi, Charlotte M. "Knowledge and use of traditional medicinal plants by the Setswana-speaking community of Kimberley, Northern Cape of South Africa." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/18589.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: The majority of South Africans still depend on the use of traditional remedies, as these are sometimes the only types of health care systems available, especially within rural communities. South Africa comprises approximately 400 000 traditional healers and an estimated 60 to 80% of individuals consulting such traditional healers. As a result, the over-harvesting of many traditional medicinal plants has become a threat to the country’s species diversity and has resulted in the scarcity of certain medicinal plant species.
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14

Mbandezelo, Mongikazi. "Bioactive compounds in a Manayi traditional medicinal product from East London." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2450.

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Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2016.<br>In Africa, herbal medicines are often used as primary treatments for a variety of ailments and diseases including HIV/AIDS and for HIV-related problems. In general, traditional medicines are not well researched scientifically in controlled studies, and are poorly regulated. Since the pharmacological effectiveness of natural products is affected by several native and foreign factors, studies on the variations of chemical composition and biological activity of these medicines are necessary. The processes of investigat
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15

Weideman, Liezel. "An investigation into the antibacterial activities of medicinial plants traditionally used in the Eastern Cape to treat secondary skin infections associated with burn wounds." Thesis, Nelson Mandela Metropolitan University, 2005. http://hdl.handle.net/10948/172.

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Traditional medicine has a long history of being used for treating various ailments ranging in severity. Although traditional medicine has typically been the health care for the poorest levels of society, there is a worldwide growth in popularity. The growing popularity of traditional medicine, termed the green boom, may be ascribed to people taking a more holistic approach to maintain their health. Traditional medicine is widely used on a regular basis by 70% of South Africans. Various indigenous medicinal plants are used for the preparation of traditional herbal medicine. These plants are mo
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16

Dilika, Fikile. "The medicinal value of Amaryllidaceae and Asteraceae species used in male circumcision." Thesis, Connect to this title online, 2002. http://upetd.up.ac.za/thesis/available/etd-04112007-153554/.

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17

Polori, Ketlareng Liza. "The medicinal properties of ipomoea oblongata E.Mey. ex Choisy." Thesis, Bloemfontein: Central University of Technology, Free State, 2014. http://hdl.handle.net/11462/671.

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Thesis (M. Tech. (Biomedical Technology)) -- Central University of Technology, Free State, 2014.<br>Traditional medicine has been known by mankind since ancient times as a healthcare system. All cultures have used herbs throughout history and it was an integral part of the development of modern civilization. Primitive man observed and appreciated the great diversity of plants available to him. Plants provided food, clothes, shelter and medicine and still play a vital role in rural villages of South Africa. The medicinal uses of plants and animals have been developed through trial and error. He
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18

Nortje, Janneke Margaretha. "Medicinal ethnobotany of the Kamiesberg, Namaqualand, Northern Cape Province, South Africa." Thesis, 2012. http://hdl.handle.net/10210/6278.

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M.Sc.<br>Scientific relevance: Qualitative and quantitative data is presented that give a new perspective on the traditional medicinal plants of the Khoisan (Khoe-San), one of the most ancient of human cultures. The data is not only of considerable historical and cultural value, but allows for fascinating comparative studies relating to new species records, novel use records and the spatial distribution of traditional medicinal plant use knowledge within the Cape Floristic Region. Aim of the study: A detailed documentation and quantitative analysis of medicinal plants of the Kamiesberg area (a
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19

Muhizi, Thèoneste. "The extraction, purification and evaluation of compounds from the leaves of Leonotis Leonorus for anticonvulsant activity." Thesis, 2002. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The aim of this study is to isolate and evaluate the anticonvulsant components from the leaves of Leonotis leonorus (L) R.aR. and to see if there is any change in activity with the origin of the plant material and I or the season in which plant material is collected. Therefore, in this study, two sites were chosen for collection of plant material and the collection was made in summer and in winter. Chemical, physical and pharmacological methods were used to isolate, identify and to evaluate compounds isolated from the leaves of Leonotis leonorus for anticonvulsant activity.
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20

McGaw, Lyndy Joy. "Evaluation of anthelmintic, antiamoebic and antibacterial activity in traditional South African medicinal plants." Thesis, 2001. http://hdl.handle.net/10413/10201.

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Traditional medicine in southern Africa draws upon a vast selection of plants to treat gastrointestinal disorders such as diarrhoea and intestinal parasites. The evaluation of these plants for biological activity is necessary, both to substantiate the use of these plants by healers, and also a possible lead for new drugs or herbal preparations. After a survey of the existing ethnobotanical literature, plants used to treat stomach ailments such as diarrhoea, dysentery or intestinal worm infestations were selected and submitted to bioassays according to their traditional uses. Extracts of the ch
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21

Tshikalange, T. E. (Thilivhali Emmanuel). "The traditional use of medicinal plants to treat sexually transmitted diseases." Diss., 2003. http://hdl.handle.net/2263/25889.

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All six plants studied (Senna petersiana, Terminalia sericea, Cassine transvaalensis, Elephantorrhiza burkei, Rauvolfia caffra and Anredera cordifolia) proved to have considerable antibacterial activity. The water extracts of five of the six plants tested, showed activity against Bacillus pumilis, B. subtilis and Staphylococcus aureus respectively. Water extracts from S. petersiana showed a significant antibacterial activity by inhibiting all Gram-positive and two Gram-negative bacteria. A cytotoxicity assay of three plants (S. petersiana, T. sericea and A. cordifolia) on primary vervet monkey
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22

Van, der Kooy Frank. "Characterisation, synthesis and antimycobacterial activity of naphthoquinones isolated from Euclea natalensis." Diss., 2004. http://hdl.handle.net/2263/24614.

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TB is still one of the world's biggest killers. Immunosuppresion induced by AIDS caused a rise in the incidence of TB during the past decade. The search for new drugs to effectively treat TB remains one of the big challenges facing the scientific community. Drugs from plants have been used for centuries to treat various human diseases with varying degrees of success. South Africa with its big resource of plants and ethnobotanical knowledge is an ideal place to screen for anti- TB compounds. The Zulu tribe of South Africa used the root bark of Euclea nata/ensis A.DC. to treat TB related symptom
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23

Anokwuru, Chinedu Prosper. "Phytochemical, biological and toxicity studies of terminalia sericea burch. (Combretaceae)." Thesis, 2018. http://hdl.handle.net/11602/1110.

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PhD (Chemistry)<br>Department of Chemistry<br>Terminalia sericea Burch. ex. DC (Combretaceae) is one of the 50 most popular medicinal plants in Africa. The fruit, leaves, stems and roots are commonly used for the treatment of cough, skin infections, diabetes, diarrhoea, venereal diseases and tuberculosis. However, the roots are most commonly used in the preparation of traditional medicines. Pharmacological studies have revealed that the crude root extracts display antibacterial activity against several Gram-positive and Gram-negative bacteria. Anolignan b, termilignan b and arjunic acid are re
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24

Long, Helen Selma. "The ethnobotany and pharmacognosy of selected Cape herbal medicines." Thesis, 2014. http://hdl.handle.net/10210/11342.

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M.Sc. (Botany)<br>A few poorly studied Cape herbal medicinal plants of historic and potential commercial interest which form part of the traditional medicine system of the Cape Region have been selected for this study. These are Centella glabrata L., Olea europaea L. subsp. africana (Mill.), Rafnia amplexicaulis (L.) Thunb. and Tulbaghia alliacea L.f. Centella C. asiatica is mainly used to treat skin conditions and wounds, tuberculosis and coughs and cooked and eaten as a vegetable in South Africa. The treatment of heartburn in the Wild Coast is a recent record. Decoctions of the leaves and st
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25

Vermaak, Ilze. "Hoodia gordonii: quality control and biopharmaceutical aspects." 2011. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000474.

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D. Tech. Pharmaceutical Sciences.<br>Aims of the research project was to develop and optimise rapid quality control methods for H. gordonii raw material and products. The second aim was to determine whether the perceived active component of H. gordonii (P57) is transported across porcine intestinal and buccal mucosa.
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26

Tarirai, Clemence. "Effect of commonly consumed botanicals on drug efflux across intestinal epithelial cells and excised tissues." 2011. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000750.

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27

Pillay, Candice Claudia Natasha. "Anti-inflammatory and anti-bacterial activity of South African Erythrina species." Thesis, 2000. http://hdl.handle.net/10413/10248.

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An investigation was undertaken to determine whether Erythrina species indigenous to South Africa contained the same type of compounds as Erythrina species not found in South Africa and to determine whether they displayed any anti-inflammatory and antibacterial activity. Phytochemical analysis was conducted using thin layer chromatography. A great similarity was found in the leaf profiles of the species being studied. The leaf and bark extracts of E. caffra and E. lysistemon appear to have similar profiles when viewed under normal light and ultraviolet light, (254 and 366 nm). These two specie
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