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Marshall, Holly Elizabeth, Matthew Grainger, Niti Sukumal, and Tommaso Savini. "The threat of free-ranging domestic dog to native wildlife: implication for conservation in Southeast Asia." Raffles Bulletin of Zoology 70 (April 8, 2022): 275–88. https://doi.org/10.26107/RBZ-2022-0012.
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Marshall, Holly Elizabeth, Grainger, Matthew, Sukumal, Niti, Savini, Tommaso (2022): The threat of free-ranging domestic dog to native wildlife: implication for conservation in Southeast Asia. Raffles Bulletin of Zoology 70: 275-288, DOI: 10.26107/RBZ-2022-0012
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Rowlands, Jonathan. "Difficult texts: ‘A dog at the table’ in Matthew 15.21–28." Theology 122, no. 4 (2019): 285–88. http://dx.doi.org/10.1177/0040571x19843749.
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This article addresses the story of the Canaanite woman in Matthew 15.21–28 and Jesus’ likening of the woman to a ‘dog’ in verse 26. It provides an overview of the passage as a whole and deals in more detail with this imagery.
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Grant, Alec. "Living with a black dog Matthew Living with a black dog and AinsleyJohnstone Constable and Robinson£7.9980pp97818452974351845297431." Mental Health Practice 13, no. 5 (2010): 12. http://dx.doi.org/10.7748/mhp.13.5.12.s14.
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Barraclough, Peter. "Living with a Black Dog Matthew Living with a Black Dog and AinsleyJohnstone Constable & Robinson 80pp £7.99978 1 84529 743 51845297431." Nursing Standard 23, no. 34 (2009): 31. http://dx.doi.org/10.7748/ns.23.34.31.s37.
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Gwinn, Dana, Jimmy Lai, Alice Rico, et al. "Abstract 1733: XL495 is a potent, selective, and orally bioavailable inhibitor of PKMYT1." Cancer Research 85, no. 8_Supplement_1 (2025): 1733. https://doi.org/10.1158/1538-7445.am2025-1733.
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Background: Protein kinase, membrane-associated tyrosine/threonine-1 (PKMYT1) phosphorylates cyclin-dependent kinase 1 (CDK1) at threonine-14 (Thr14), inhibiting the catalytic activity of the CDK1/cyclin B kinase complex, which blocks cells in G2 from entering M phase. Disruption of this PKMYT1-mediated G2/M checkpoint in cancer cells allows mitotic events to occur while DNA synthesis is still ongoing, resulting in catastrophic levels of DNA damage and cell death. We report preclinical data for XL495, a potent and selective orally bioavailable small molecule inhibitor of PKMYT1. Methods: XL495 selectivity was assessed using a KinomeProfiler™ assay. Viability across hundreds of cancer lines was assessed using the PRISM screen. Viability of cell lines treated with a combination dose response matrix was measured using CellTiterGlo®. Antitumor activity of XL495 orally administered as a single agent was evaluated in a colorectal cancer and a breast cancer cell line-derived xenograft (CDX) model. Antitumor activity of XL495 in combination with irinotecan or gemcitabine was evaluated in a colorectal cancer CDX model. Phosphorylation of CDK1 at Thr14 and phosphorylation of KAP1 at Ser824 from tumors was measured by AlphaLISA™. Drug-like properties were assessed and pharmacokinetic (PK) parameters were determined following administration of XL495 in rat, dog, and monkey. Results: XL495 is a potent, selective inhibitor of PKMYT1 in biochemical and cellular assays. Cancer cell lines with CCNE1 amplification were more sensitive to XL495 than other models. XL495 demonstrated dose-dependent antitumor activity, inhibition of phosphorylation of CDK1 at Thr14, and induction of phosphorylation of KAP1 at Ser824 in CDX tumors. When XL495 was dosed in combination with gemcitabine or irinotecan in the CDX model, tumor regression was achieved. XL495 showed favorable drug-like properties including high solubility and moderate permeability in Caco-2 cells. XL495 exhibited low clearance (CL) in rat and monkey and moderate CL in dog. Bioavailability was high in rat and moderate in dog and monkey. Preliminary PK assessments predict low CL and a long half-life for XL495 in humans. Conclusions: XL495 is potentially a best-in-class PKMYT1 inhibitor. PK assessments in conjunction with preclinical antitumor activity suggest that once-daily oral administration of XL495 may achieve clinical activity alone or in combination with DNA-damaging agents. XL495 is currently under investigation in a phase 1 first-in-human study in patients with advanced solid tumors (NCT06630247). Citation Format: Dana Gwinn, Jimmy Lai, Alice Rico, Christopher Kochansky, Nina M. Muñoz, Ragadeepthi Tunduguru, Aditya Kumar, Pragalath Sundararajan, Akhil Choppa, Donna Fong, Mi Chen, Amy Hildebrand, Jeremy Murray, Christopher Szeto, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Wei Xu, Paul Gillespie, Paige Mahaney, Dana T. Aftab, Lisa D. Belmont, Jae H. Chang. XL495 is a potent, selective, and orally bioavailable inhibitor of PKMYT1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1733.
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Degner, Nicholas R., Ricardo Galvan-Castillo, Jose Alexander, et al. "1030. Chasing the Long Tail of Infectious Diseases: Detecting Capnocytophaga canimorsus and Pasteurella multocida Infections with A Plasma-based Microbial Cell-Free DNA Next Generation Sequencing Test." Open Forum Infectious Diseases 8, Supplement_1 (2021): S605—S606. http://dx.doi.org/10.1093/ofid/ofab466.1224.
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Abstract Background Capnocytophaga canimorsus (Cc) and Pasteurella multocida (Pm) are gram negative bacterial commensal pathogens typically from dogs or cats that can cause severe infection in humans when spread through licks, scratches or bites. The diagnosis of these infections can be limited by: (1) their fastidious nature and difficulty to culture; (2) the nonspecific manifestations of the infections; and (3) the unreliability of dog or cat exposure history. Open-ended microbial cell free DNA (mcfDNA) next-generation sequencing (NGS) offers a potential solution to overcome these limitations. Methods The Karius TestTM (KT) developed and validated in Karius’s CLIA certified/CAP accredited lab in Redwood City, CA detects mcfDNA in plasma. After mcfDNA is extracted and NGS performed, human reads are removed, and remaining sequences are aligned to a curated database of > 1500 organisms. McfDNA from organisms present above a statistical threshold are reported and quantified in molecules/µL (MPM). KT detections of Cc and Pm were reviewed from August 2017 - present; clinical information was obtained with test requisition or consultation upon result reporting. Results KT detected 5 cases of Cc (25,039 MPM +/- 41,062) and 8 cases of Pm (33,264 MPM +/- 69,301) (Table 1). All detections of Cc were in adults (60% male) and included 2 cases of culture-negative endocarditis (one with known liver disease) and one case of sepsis with diffuse rash. Pm detections occurred in 6 adults and 2 children (75% male) and included 2 cases of culture-negative endocarditis, and single cases each of endovascular graft infection, pneumonia, fever of unknown origin, and a cranial dog bite complicated by an abscess. Two patients had immunocompromising conditions including neuroblastoma and aplastic anemia. Conclusion Unbiased, plasma-based mcfDNA NGS provides a rapid, non-invasive test to diagnose diverse clinical infections by Cc and Pm. These cases highlight the potential of the KT to diagnose infections caused by fastidious/unculturable pathogens with non-specific clinical manifestations and broad differential diagnoses. Disclosures Nicholas R. Degner, MD, MPH, MS, Karius Inc. (Employee, Shareholder) Ricardo Galvan-Castillo, MD, Karius Inc. (Employee, Shareholder) Jose Alexander, MD, D(ABMM), FCCM, CIC, SM, MB(ASCP), BCMAS, Karius (Employee) Aparna Arun, MD, Karius (Employee) Ann Macintyre, DO, Karius, Inc. (Employee) Bradley Perkins, MD, Karius, Inc. (Employee) Asim A. Ahmed, MD, Karius, Inc. (Employee) Matthew Smollin, PharmD, Karius, Inc. (Employee)
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Atherton, Matthew J., Antonia Rotolo, and Nicola J. Mason. "Abstract 1363: Preclinical development of bispecific CAR-T cells for canine B cell malignancies." Cancer Research 82, no. 12_Supplement (2022): 1363. http://dx.doi.org/10.1158/1538-7445.am2022-1363.
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Abstract Chimeric antigen receptor (CAR)-T cells targeting CD19 have revolutionized the treatment of B cell malignancies in people. However, post-treatment loss of CD19 has emerged as an adaptive mechanism of resistance. Pet dogs that develop tumors spontaneously in an immune competent setting represent a compelling parallel population of patients to study next generation cancer immunotherapies. Comparative trials at the University of Pennsylvania are investigating the activity of canine CAR-T cells targeting either CD19 or CD20 in canine B cell lymphoma patients and have revealed a favorable safety profile with early signs of anti-tumor activity. Aligned with experiences in human trials, expansion of CD20-negative B cells has been observed in dogs treated with anti-CD20 CAR-T cells. Bispecific CAR-T cells that simultaneously target two antigens to mitigate antigen escape have encouraging efficacy profiles in human patients. Thus, we designed a dual-targeting CAR specific for canine B cell antigens. A second-generation canine CAR construct targeting both CD19 and CD20 with a 28z signaling domain was cloned into the MSGV1 backbone. Chimeric retrovirus encoding RD114 and VSV-G envelope proteins and the CAR construct was made using GP2-293 cells. Jurkat NFAT-GFP reporter cells and primary T cells from dogs diagnosed with high grade B cell lymphoma were retrovirally transduced with bispecific CARs. Antigen specific reactivity was assessed against cell lines with variable CD19 and CD20 expression patterns. The CD19-CD20 CAR was efficiently transduced, with stable expression in both Jurkat and primary canine T cells. Jurkat reporters revealed dual-specific CAR signaling after co-culture with CD19+ and/or CD20+ target cells. Primary canine CAR-T cells expanded in vitro and exhibited CAR-specific proliferation and cytotoxicity against CD19+ CD20+ target cells. Preclinical manufacture of functional, bispecific anti-CD19 anti-CD20 canine CAR-T cells is feasible. A clinical trial recruiting dogs diagnosed with B cell cancer will assess safety and efficacy of this approach in vivo, with the aim of establishing the dog as a compelling model to appraise the ability of bispecific CAR-T cells to overcome therapeutic failures secondary to antigen loss. Citation Format: Matthew J. Atherton, Antonia Rotolo, Nicola J. Mason. Preclinical development of bispecific CAR-T cells for canine B cell malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1363.
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Nadal, Francesc. "Edney, Matthew H. (2019). Cartography: The Ideal and Its History." Documents d'Anàlisi Geogràfica 69, no. 3 (2023): 647–49. http://dx.doi.org/10.5565/rev/dag.848.
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Rankin, Shelley C., and Stephen D. Cole. "An Outbreak of New Delhi Metallo--Lactamase-5 (blaNDM-5)–Producing Escherichia coli in Companion Animals in the United States." Infection Control & Hospital Epidemiology 41, S1 (2020): s21. http://dx.doi.org/10.1017/ice.2020.496.
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Background: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) in companion animals will be a game changer for infection prevention and control strategies in veterinary and human healthcare facilities. CRE have emerged as an important cause of human healthcare-associated infections and are a major clinical and public health problem. Although reports of CRE from animals are still very rare, they have been documented in China, Europe, and the United States. Methods: In April 2019, a passive veterinary surveillance system identified the blaNDM-5 gene in an E. coli isolated from a dog in Philadelphia in July 2018. CRE are reportable to the Philadelphia Department of Public Health (PDPH), and in May 2019, the Matthew J. Ryan Veterinary Hospital at the University of Pennsylvania (MJRVH) reported a cluster of carbapenem-resistant E. coli (CR-E. coli) isolated from 14 animals to the PDHP. This cluster of 17 isolates, that all contained a blaNDM-5 gene, was the first report of a CR-E. coli outbreak at a US veterinary facility. The first isolate, E. coli 24213-18, was sequenced on the Pacific Biosciences (PacBio) Sequel Sequencer and has been uploaded to GenBank. Whole genome sequencing was performed on all 17 isolates using the Illumina MiSeq platform. Antimicrobial resistance genes were identified from the National Center for Biotechnology Information Pathogen Detection Isolates Browser using AMRFinder. Results: PacBio sequencing confirmed E. coli ST167 and identified a circular IncFII plasmid of 139,547 bp that contained the blaNDM-5 gene, along with many additional resistance genes. In June 2019, a retrospective review of hospital records was completed and showed that, from July 2018, 17 CR- E. coli were isolated from 14 animals. Conclusions: Control of CRE infections in human healthcare settings is challenging because the organisms colonize the gastrointestinal tract and can go undetected. The same issue is to be expected with companion animals. Healthcare-associated spread of CRE E. coli in a veterinary facility emphasizes the importance of rapidly identifying and characterizing carbapenem-resistant isolates from animals. Methods to control the spread of CRE in veterinary medical settings have not yet been studied, and related investigations will be critically important to limit the transmission of these pathogens in animal populations. The risk of transmission of CRE from animals to people is currently poorly understood. CRE will be a major challenge across all health fields as these organisms become more prevalent in the community. It is likely that a ‘One Health’ approach to surveillance, infection prevention, and antimicrobial stewardship will be required to limit the spread and potential global dominance of CRE.Funding: NoneDisclosures: None
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Capriotti, Emidio, Ludovica Montanucci, Giuseppe Profiti, et al. "Fido-SNP: the first webserver for scoring the impact of single nucleotide variants in the dog genome." Nucleic Acids Research 47, W1 (2019): W136—W141. http://dx.doi.org/10.1093/nar/gkz420.
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Abstract As the amount of genomic variation data increases, tools that are able to score the functional impact of single nucleotide variants become more and more necessary. While there are several prediction servers available for interpreting the effects of variants in the human genome, only few have been developed for other species, and none were specifically designed for species of veterinary interest such as the dog. Here, we present Fido-SNP the first predictor able to discriminate between Pathogenic and Benign single-nucleotide variants in the dog genome. Fido-SNP is a binary classifier based on the Gradient Boosting algorithm. It is able to classify and score the impact of variants in both coding and non-coding regions based on sequence features within seconds. When validated on a previously unseen set of annotated variants from the OMIA database, Fido-SNP reaches 88% overall accuracy, 0.77 Matthews correlation coefficient and 0.91 Area Under the ROC Curve.
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Solana Solana, Miguel. "Desmond, Matthew (2017). Desahuciadas. Pobreza y lucro en la ciudad del siglo XXI." Documents d'Anàlisi Geogràfica 64, no. 2 (2018): 407. http://dx.doi.org/10.5565/rev/dag.463.
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Sembiring, Raharja, and Asigor Parongna Sitanggang. "Resolusi Konflik Berbasis Permohonan Kelima dalam Doa Bapa Kami dan Purpur Sage dalam Masyarakat Karo." DUNAMIS: Jurnal Teologi dan Pendidikan Kristiani 9, no. 1 (2024): 417–38. http://dx.doi.org/10.30648/dun.v9i1.1397.
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Abstract. The phrase of kαὶ ἄφες ἡμῖν τὰ ὀφειλήματα ἡμῶν … (and forgive us our debts) in Matthew 6:12 requires forgiveness of others' faults to obtain divine forgiveness. By using the word analysis approach and the Sermon on the Mount in The Gospel of Matthew as a framework, forgiveness in the fifth petition of the Lord's Prayer is a marker and moral ethic of the disciples' identity. The theology of forgiveness which requires forgiveness of others' sins, which is built on an analysis of purpur sage based cultural reconciliation in Karo society, can become an agreement to conflict resolution in the Karo-Christian community.Abstrak. Frasa kαὶ ἄφες ἡμῖν τὰ ὀφειλήματα ἡμῶν … (dan ampunilah kami akan kesalahan kami) dalam Matius 6:12 seolah mensyaratkan pengampunan atas kesalahan sesama untuk mendapatkan pengampunan illahi. Dengan menggunakan Khotbah di Bukit dalam Injil Matius sebagai bingkai kerja atau hermeneutical framework, pengampunan pada permohonan kelima (the fifth petition) dalam Doa Bapa Kami merupakan penanda kualitas dan identitas para murid. Teologi pengampunan yang mensyaratkan pengampunan atas dosa sesama yang dibangun dalam analisis rekonsiliasi berbasis kultural purpur sage dalam masyarakat Karo menjadi tawaran resolusi konflik dalam komunitas Karo-Kristen.
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Baggett, James L. "Doc: The Story of a Birmingham Jazz Man by Frank “Doc” Adams and Burgin Matthews." Alabama Review 67, no. 4 (2014): 416–18. http://dx.doi.org/10.1353/ala.2014.0039.
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Sisga Desriman Zebua, Mega Intan Tambunan, Windi Jore Lasenov Sinamo, Jeri Hezekiel Lumbantobing, Sofia Sri Soradinah Wau, and Yubilate Chriswell Zebua. "Memahami Makna Doa yang Benar dan Implikasinya dalam Kehidupan Sehari-hari Matius 7:7." Sinar Kasih: Jurnal Pendidikan Agama dan Filsafat 2, no. 1 (2023): 41–57. https://doi.org/10.55606/sinarkasih.v2i1.241.
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Many people think that prayer is a ritual carried out to ask the creator or someone they believe in. But many people also believe that prayer is not just about asking those they trust, but also that in prayer there is a form or form of giving thanks to those they trust. The writing method used is a qualitative approach. The author uses valid data sources from various books, journals, Bible Works, and the Bible. The purpose of this writing is for believers to understand prayer and live prayer in their daily lives correctly. What the author will discuss in this scientific work is how the theological study of prayer in Matthew 7:7, then how prayer is in the Greek world then how prayer is in the Old Testament, then what prayer is like in the Synagogue, then what prayer is like in the New Testament and what are the implications of true prayer in everyday life. Prayer is the breath of life for believers which must continue to be done by working and praying.
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Fan, Haitian, Wei Sun, Zhe Sun, Feng Gao, and Weimin Gong. "Expression, purification, crystallization and preliminary X-ray diffraction analysis of Deg5 fromArabidopsis thaliana." Acta Crystallographica Section F Structural Biology and Crystallization Communications 68, no. 7 (2012): 839–41. http://dx.doi.org/10.1107/s1744309112023603.
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Arabidopsis thalianaDeg5 is an ATP-independent serine protease which resides on the luminal side of the thylakoid in chloroplasts. Deg5 and another Deg/HtrA-family protease, Deg8, have a synergistic function in the turnover of the D1 protein of photosystem II (PSII), which is prone to damage arising from high light exposure. An inactive mutant of the protein, Deg5S266A, was overexpressed inEscherichia coli. After purification and crystallization, crystals that diffracted to 2.6 Å resolution were obtained. The crystals belonged to the monoclinic space groupC2, with unit-cell parametersa= 109.1,b= 126.0,c= 83.3 Å, β = 102.9°, and contained three molecules in the asymmetric unit. The calculated Matthews coefficient and solvent content were 3.0 Å3 Da−1and 59.0%, respectively.
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Butterfield, Hannah, Juliana Hofstatter Azambuja, Lisa Maurer, et al. "Abstract A002: MALT1 as a regulator of tumor progression in H3K27-altered diffuse midline glioma." Cancer Research 84, no. 5_Supplement_1 (2024): A002. http://dx.doi.org/10.1158/1538-7445.brain23-a002.
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Abstract Purpose: This study evaluates MALT1 as a potential therapeutic target in H3K27-altered diffuse midline glioma (DMG). Background: H3K27-altered DMG is a devastating pediatric brain tumor that affects 200-300 individuals in the US per year. Median survival is 9-11 months, and there are virtually no long-term survivors. Despite decades of clinical trials, radiation therapy remains standard of care, extending survival by 2-3 months. Development of effective therapies for H3K27-altered DMG is a critical unmet need. MALT1 is the effector molecule of the CARMA-BCL10-MALT1 (CBM) signalosome, a cytoplasmic protein complex that drives downstream signaling, including activation of the pro-survival NF-kB transcription factor. MALT1, which possesses distinct scaffolding and protease activities, has been best characterized as an oncogenic driver in multiple lymphomas. More recently, MALT1 has been shown to act in multiple solid tumor types (breast, lung, glioblastoma) to promote cell viability, proliferation, and migration/invasion. Based on these studies, we hypothesize that MALT1 promotes H3K27-altered DMG cancer cell proliferation and survival and that MALT1 inhibition will abrogate DMG tumor progression. Methods/Results: We screened a panel of patient-derived DMG cell lines by Western blot and found that the CBM signalosome components BCL10 and MALT1 are present in all cell lines tested. We next optimized a brain-penetrant lipid nanoparticle (LNP) delivery system to achieve efficient siRNA knockdown in non-adherent DMG cells and utilized this approach to knockdown MALT1 in DIPG07, BT245, and DIPG XIII FL cell lines. Preliminary findings indicate that loss of MALT1 leads to a reduction in DMG cell viability. To complement this RNAi-based approach, we utilized the blood brain barrier (BBB)-penetrant small molecule MALT1 inhibitor “M1i-124.” This compound, discovered in our laboratory, is a protein-protein interaction inhibitor that disrupts the binding of BCL10 and MALT1 and blocks both MALT1 scaffold and protease activities (manuscript in revision). M1i-124 treatment, at nanomolar-range doses, reduces the viability of both DIPG07 and BT245 DMG cell lines. Conclusions: We found that both siRNA-mediated MALT1 knockdown and the small molecule MALT1 inhibitor M1i-124 are toxic to DMG cells. These preliminary findings point to the potential for therapeutic targeting of MALT1 in H3K27-altered DMG. Future Directions: We will next evaluate the mechanism by which MALT1 knockdown or pharmacological inhibition impacts DMG cell survival using RNA-sequencing and proteomics approaches. We will also use H3K27-altered DMG xenograft models to evaluate the impact of MALT1 inhibition on H3K27-altered DMG tumor progression in vivo. Citation Format: Hannah Butterfield, Juliana Hofstatter Azambuja, Lisa Maurer, Saigopalakrishna S. Yerneni, Andrea Cruz, Matthew Halbert, Taylor Gatesman, Sameer Agnihotri, Peter C. Lucas, Linda M. McAllister-Lucas. MALT1 as a regulator of tumor progression in H3K27-altered diffuse midline glioma [abstract]. In: Proceedings of the AACR Special Conference on Brain Cancer; 2023 Oct 19-22; Minneapolis, Minnesota. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_1):Abstract nr A002.
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Michniewicz, Filip, Riccardo Cazzoli, Jessica Bell, et al. "Abstract 525: A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG)." Cancer Research 84, no. 6_Supplement (2024): 525. http://dx.doi.org/10.1158/1538-7445.am2024-525.
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Abstract Diffuse Midline Gliomas (DMG) are incurable pediatric brain tumors driven by histone mutation H3K27M, globally reducing H3K27 trimethylation altering the epigenome and deregulating gene expression. These mutations often partner with and are strongly integrated into kinase signaling and metabolic alterations, driving aggressive tumor growth with many mechanisms which can compensate for one another and therefore evade traditional single agent therapies. Copper over-accumulation has been linked to epigenetic, kinase and metabolic dysregulation in various cancers and neurological disorders. Copper chelators are clinically approved for use in pediatric Wilson’s Disease patients, improve neurological symptoms and are under clinical investigation for several cancers. We propose copper chelators may simultaneously target these mechanisms in DMG. We performed transcriptomic interrogation of patient datasets, in vitro investigations in a panel of DMG cell lines and an in vivo investigation using an orthotopic xenograft model of DIPG (SU-DIPGVI-Luc). Copper chelator tetraethylenepentamine-pentachloride (TEPA) was used to treat DMG cells. Transcriptomic (RNA-Seq), proteomic, phospho-proteomic and metabolomic (Mass Spectrometry) investigations, western blots and immunofluorescent microscopy determined efficacy and mechanism. In vivo investigation consisted of survival study with concurrent luminescence imaging, histology, and copper assay. We demonstrate copper chaperone transcript expression is increased in DMG patient samples compared to non-DMG samples. In vitro, apoptosis and growth assays demonstrated H3K27M DMG were more sensitive to TEPA than H3-WT DMG. In H3K27M DMG, TEPA downregulated ATP, GTP and SAM metabolism which corresponded with downregulated kinase signaling and altered H3K27 trimethylation and DNA methylation patterns around cell cycle genes. Affected genes included those regulating centrosome segregation and ATP synthesis. Further transcriptomic and proteomic investigations highlighted TEPA downregulated G2-M phase kinase pathways, with immunofluorescence demonstrating TEPA reduced expression of mitotic marker p-H3S10 and epigenetic methylators EZH2 and DNMT1. In vivo, TEPA reduced brain copper accumulation, eliminated tumors and increased survival in an orthotopic patient-derived xenograft DMG model. Collectively, our data indicates TEPA induced multi-modal targeting of M-phase cell cycle progression through epigenetic, kinase signaling and metabolic mechanisms. Efficacy was observed both in vitro and in vivo, providing a promising basis for future investigation of copper chelators in DMG. We propose copper-chelation is a viable therapeutic strategy for DMG patients warranting clinical investigation. Citation Format: Filip Michniewicz, Riccardo Cazzoli, Jessica Bell, Federica Saletta, Ensieh Poursani, Jourdin R. Rouaen, Tyler Shai-Hee, Vu Pham, Toni Rose Jue, Matthew Biery, Liesl Bramberger, Terry Lim, Aaminah Khan, Federico M. Giorgi, Daniele Mercatelli, Chelsea Mayoh, Giuseppe Cirillo, Alexander Macmillan, Renee Whan, Christopher T. Barlow, Maria Tsoli, Nicholas Vitanza, Scott Berry, Pouya Faridi, David Ziegler, Orazio Vittorio. A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 525.
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Przulj, N., and V. Momčilović. "Dry matter and nitrogen accumulation and use in spring barley." Plant, Soil and Environment 49, No. 1 (2011): 36–47. http://dx.doi.org/10.17221/4087-pse.
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During growth, kernel of cereals can be provided with carbohydrate and nitrogen (N) from the translocation of pre-anthesis accumulated reserves stored either in the vegetative plant parts or from current assimilation during kernel development. This study was conducted to assess the effects of nitrogen level and cultivars on dry matter and N accumulation and mobilization during pre-anthesis and post-anthesis. Twenty two-rowed spring barley (Hordeum vulgare L.) cultivars were grown on a non-calcareous chernozem soil in four growing seasons (1995–1998) atNovi Sad (45°20'N, 15°51'E,86 m a.s.l.) at two nitrogen levels. Dry matter accumulation before anthesis ranged from less than 50% in unfavorable to 90% in favorable growing conditions. Dry matter translocation occurred in favorable growing conditions only. Pre-anthesis accumulated N represented 57–92% and 54–129% of total N at maturity at the low and high N levels, respectively. Translocated N represented 41–85% and 37–153% of grain N at the low and high N level, respectively. N losses occurred in favorable growing conditions when anthesis N exceeded 150 kg/ha. N accumulation during grain filling was in negative correlation with dry matter and N accumulation before anthesis. The N harvest index was 0.57–0.63 and 0.71–0.74 in unfavorable and favorable growing conditions, respectively. Selection of genotypes with a higher ability of pre-anthesis reserve utilization or genotypes with longer leaf area duration after anthesis may be two possible solutions in spring barley breeding for Mediterranean growing conditions.
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Timpanaro, Andrea, Edward Song, Matthew C. Biery, et al. "Abstract 6400: Preclinical efficacy of combinatorial B7-H3 CAR T cell and ONC206 treatment in DIPG/DMG." Cancer Research 85, no. 8_Supplement_1 (2025): 6400. https://doi.org/10.1158/1538-7445.am2025-6400.
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B7-H3 CAR T cell treatment in combination with ONC206 aims to assess benefit and significant extension of survival in orthotopic DIPG mouse models. BACKGROUND. Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric tumor arising in the pons and affecting over 300 children each year in the United States. Chimeric antigen receptor (CAR) T cells, a targeted immunotherapy showing remarkable results in treating hematologic cancers, have recently been translated to children with DIPG. B7-H3 is a protein expressed in nearly all DIPG but present at only low levels in normal brain tissue. Seattle Children’s first-in-human phase 1 clinical trial of repeated intracranial anti-B7-H3 CAR T cells (BrainChild-03 trial, NCT04185038) found the highest planned dose (100 million CAR T cells) to be tolerable. We also demonstrated a survival of 20.1 months for treated patients, but while 3 patients are alive beyond 42 months, response to therapy was not universal. To uncover a beneficial combinatorial strategy, we tested B7-H3 CAR T cells with ONC206, a small molecule imipridone targeting ClpP and DRD2, being evaluated in the PNOC023 clinical trial (NCT04732065) for pediatric patients with CNS tumors. METHODS. The combinatorial strategy was performed against multiple DIPG models (i.e., PBT-22FH, PBT-24FH, PBT-27FH, PBT-29FH, and SU-DIPG-XIII) before being validated in orthotopic xenograft DIPG mouse models. B7-H3 CAR T cells (1 million) were intracranially delivered at day 7, whereas ONC206 (50 mg/kg) was administered twice a week via oral gavage. RESULTS. We initially assessed an ONC206 IC50 at approximately 250 nM and demonstrated a pro-apoptotic effect in various DIPG models. Next, we showed that ONC206 induces mitochondrial dysfunction, which limits tumor cell respiration and activates cell death pathways. After a 120h treatment with ONC206, we observed upregulation of Caspase-3, Caspase-7, ATF4, CHOP, ClpP, and DR5, whereas levels of B7-H3 and DRD2 remained constant.Given that B7-H3 CAR T cells are highly effective as single agents in preclinical settings, we used lower Effector:Tumor (E:T) ratios and low concentrations of ONC206, revealing a significant additive effect in the models studied (p-value < 0.003). Interestingly, the phenotype of CAR T cells was unaffected by ONC206, and multiplex cytokine assays not only showed unaltered levels of TNF-α and IFN-γ, but also detected increased levels of IL2, IL29, VEGFA, IP10, and Granzyme B post-treatment. Preclinical studies confirmed an additive benefit in the aggressive and metastatic SU-DIPG-XIII model, significantly extending the survival of mice up to 94 days (p-value < 0.005), compared to mice treated solely with B7-H3 CAR T cells (median survival = 25 days). CONCLUSIONS. B7-H3 CAR T cells and ONC206 may have a combinatorial benefit. Therefore, future studies will continue to validate these findings, optimize dosing strategies, and assess immunocompetent DIPG models. Citation Format: Andrea Timpanaro, Edward Song, Matthew C. Biery, Ryma Toumi, Davina Lau, Leo Elena-Sanchez, Michael Meechan, Ashmitha Rajendran, Jason Wendler, Joshua Gustafson, Lily Winter, Carl Koschmann, Myron Evans, Siobhan Pattwell, Shannon Oda, Jessica Foster, Matthew D. Dun, Michael C. Jensen, Nicholas A. Vitanza. Preclinical efficacy of combinatorial B7-H3 CAR T cell and ONC206 treatment in DIPG/DMG [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6440.
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Bakar, Burhan, and Ugur Tirnakli. "Return distributions in dog-flea model revisited." Physica A: Statistical Mechanics and its Applications 389, no. 17 (2010): 3382–86. http://dx.doi.org/10.1016/j.physa.2010.04.037.
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Tesler, Michael, and Mary McThomas. "The racialization of pit bulls: What dogs can teach us about racial politics." PLOS ONE 19, no. 6 (2024): e0305959. http://dx.doi.org/10.1371/journal.pone.0305959.
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Many have argued that discrimination against pit bulls is rooted in the breed’s association with Black owners and culture. We theoretically and empirically interrogate that argument in a variety of ways and uncover striking similarities between the racialization of pit bulls and other racialized issues (e.g., poverty and crime) in public opinion and policy implementation. After detailing the reasons to expect pit bulls to be racialized as Black despite dog ownership in the U.S. generally being raced as white, the article shows: (1) Most Americans associate pit bulls with Black people. (2) Anti-Black attitudes, in general, are significant, independent, predictors of both anti-pit views and of preferring other breeds over them; (3) stereotypes of Black men as violent, in particular, are significant, independent, predictors of both anti-pit views and of preferring other breeds over them. (4) Implicit racialization through a national survey experiment further eroded support for legalizing pits, with the treatment effect significantly conditioned by respondent’s race. And (5) state-level racial prejudice is a significant negative predictor of enacting legislation to preempt breed-specific bans. We conclude with our findings’ broader insights into the nature of U.S. racial politics. Michael Tesler, mtesler@uci.edu, corresponding author, is Professor of Political Science at UC Irvine; Mary McThomas, mary.mcthomas@uci.edu, is Associate Professor of Political Science at UC Irvine. An earlier version of this paper was presented at the American Political Science Association’s annual meeting. We thank Maneesh Arora, Rachel Bernhard, Nathan Chan, Louis Pickett, David Sears, DeSipio, Adam Duberstein, Jane Junn, Claire Kim, Jessica Manforti, J. Scott Matthews, Justin.
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Tang, Victoria, Kaichen Ouyang, Zhenbang Liu, and František Šťáhlavský. "Three new species of genus Scorpiops Peters, 1861 from Tibet, China (Scorpiones: Scorpiopidae), with implications for the diagnostic values of qualitative characters." Euscorpius 2024, no. 394 (2024): 1–40. https://doi.org/10.5281/zenodo.13356435.
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Three new species of genus<em> Scorpiops</em> Peters, 1861 are described from Tibet Autonomous Region, China. <em>S. deshpandei</em> <strong>sp. n</strong>. is described based on an adult male and an immature pair collected from Mêdog County, Nyingchi, with additional molecular evidence substantiating its validity against <em>S. longimanus</em> Pocock, 1893. <em>S. kovariki</em> <strong>sp. n.</strong> is featured by a single adult female from Zayü. This species is only weakly supported by its genetic distance from <em>S. jendeki</em> Kovařík, 1994, but empirical understanding of the morphological variation in <em>Scorpiops</em> species motivated us to consider them as distinct. <em>S. matthewi</em> <strong>sp. n.</strong> is based on three adult females, all collected from Xigazê. Its species delineation is based solely on morphological characteristics due to the lack of material of its morphological relative (<em>S. rufus</em> Lv & Di, 2023). New specimens of <em>S. margerisonae</em> Kovařík, 2000 are obtained from Nyêmo, Lhasa, and compared with <em>S. wrzecionkoi</em> Kovařík, 2020. A new term, “ocular islet”, is introduced to portray the periocular morphology of <em>Scorpiops</em> median ocelli, categorized into four preliminary types. Finally, a comparative matrix summarizing the quantitative and qualitative diagnostic characters of Tibetan <em>Scorpiops</em> species based on preceding publications is provided.
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Tseremoglou, Stavros, Christos Michail, Ioannis Valais, et al. "Optical Photon Propagation Characteristics and Thickness Optimization of LaCl3:Ce and LaBr3:Ce Crystal Scintillators for Nuclear Medicine Imaging." Crystals 14, no. 1 (2023): 24. http://dx.doi.org/10.3390/cryst14010024.
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The present study focuses on the determination of the optimal crystal thickness of LaCl3:Ce and LaBr3:Ce crystal scintillators for Nuclear Medicine Imaging applications. A theoretical model was applied for the estimation of the optical efficiency of the two single-crystal scintillators in terms of Detector Optical Gain (DOG). The theoretical model was validated against the experimental values of the Absolute Efficiency (AE) of the two crystals, obtained in the energy range 110 kVp–140 kVp. By fitting the theoretical model to these experimental data, the propagation probability per elementary thickness k was determined and DOG was theoretically calculated for crystal thicknesses from 0.005 cm to 2 cm, in the energy range of Nuclear Medicine Imaging. k values for LaCl3:Ce and LaBr3:Ce crystals were significantly higher compared to other single-crystal scintillators. The DOG values of the two crystals may serve as evidence that the LaBr3:Ce crystal exhibits significantly better performance compared to the LaCl3:Ce crystal. With an increase in energy, the optimum thickness increases for both crystals. Additionally, crystal efficiency generally demonstrates a decrease beyond a certain thickness. The aforementioned insights may provide valuable guidance for the design and optimization of crystal scintillators in Nuclear Medicine Imaging systems.
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Fernandez, Ester Calvo, Lorenzo Tomassoni, Xu Zhang, et al. "Abstract 5460: Discovery and validation of effective combination therapies targeting cell state-specific master regulator vulnerabilities by network-based protein activity inference in diffuse midline glioma." Cancer Research 84, no. 6_Supplement (2024): 5460. http://dx.doi.org/10.1158/1538-7445.am2024-5460.
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Abstract Diffuse Midline Glioma (DMG) are fatal pediatric brain tumors with no effective systemic therapies. We leveraged network-based methodologies to dissect tumor heterogeneity, discover Master Regulators (MR) representing pharmacologically accessible vulnerabilities of distinct DMG cell states, and validated candidate MR-reversing drugs predicted by the NYS CLIA-certified OncoTarget and OncoTreat algorithms (Cancer Discov 2023) in vivo. We first interrogated single cell DMG regulatory networks generated by ARACNe (Nat Genet 2005) with publicly available gene expression signatures from 3,039 tumor cells across 6 patients using VIPER (Nat Genet 2016) to infer single cell regulatory protein activity. Clustering of cells by protein activity defined 7 patient-independent cell states with distinct MR profiles reflecting known glial lineage markers (OPC-like-S1, OPC-like-S2, OC-like-S1, OC-like-S2, Cycling, AC-like, and AC/OPC-like). We then generated drug-induced differential protein activity from RNAseq profiles following perturbation with 372 oncology drugs in two DMG cell lines that together recapitulate the MR signatures of the cell states and used this to identify drugs that invert tumor MR activity profiles using OncoTreat. Candidate drugs predicted by OncoTarget (inhibitors of individual MRs) and OncoTreat were distinct across the cell states, and we selected five drugs targeting the OPC/cycling-like cells (Trametinib, Dinaciclib, Avapritinib, Mocetinostat, and Etoposide), and four drugs targeting the AC-like cells (Ruxolitinib, Venetoclax, Napabucasin, Larotrectonib) for further validation as these states comprised most tumor cells across patients. We generated single-cell RNAseq for 95,687 cells after 5 days of treatment with either vehicle control (n = 4) or candidate drug (n = 2-3/drug) in subcutaneous SU-DIPG-17 mouse models. We show this model recapitulates cell states seen in patients and confirm reduction in tumor growth and significant depletion of either OPC/cycling-like cells or AC-like cells in line with our drug predictions for 8/9 candidate drugs. We then treated a syngeneic (DIPG4423) orthotopic DMG model with each drug and demonstrate significant differences in survival with Avapritinib, Dinaciclib, and Trametinib. Notably, the combination of drugs targeting OPC/cycling-like and AC-like cells (i.e. Trametinib+Ruxolitinib and Avapritinib+Venetoclax) showed significantly lower tumor volumes after 2 weeks of treatment as compared to vehicles or each drug alone, and significant survival differences for some combinations. This work provides a precision medicine platform to nominate much-needed novel drug combinations addressing DMG tumor heterogeneity for further study to improve outcomes in this devastating disease. Citation Format: Ester Calvo Fernandez, Lorenzo Tomassoni, Xu Zhang, Aleksandar Obradovic, Pasquale Laise, Aaron T. Griffin, Lukas Vlahos, Junqiang Wang, Hanna E. Minns, Diana V. Morales, Christian Simmons, Matthew Gallito, Hong-Jian Wei, Zhiguo Zhang, Robyn Gartrell, Luca Szalontay, Stergios Zacharoulis, Cheng-Chia Wu, Andrea Califano, Jovana Pavisic. Discovery and validation of effective combination therapies targeting cell state-specific master regulator vulnerabilities by network-based protein activity inference in diffuse midline glioma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5460.
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Wennar and Yunita Sardo Manalu. "Doa yang Berkenan di Hadapan Allah: Studi Hermeneutik terhadap Matius 6:6-7 dalam Konteks Kehidupan Kristen Kontemporer." LAMPO: Jurnal Teologi dan Pendidikan Agama Kristen 1, no. 2 (2025): 96–115. https://doi.org/10.63832/lampo.v1i2.29.
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Abstract: Prayer is the core of Christian spirituality, yet its essence is often overshadowed by formalism, routine, or self-presentation. Matthew 6:6-7 contains Jesus' teaching on prayer, emphasizing intimacy and sincerity as the foundation for communication with God. This study employs hermeneutic and linguistic methods to analyze key terms like tameion (private space), battalogeo (vain repetition), and ethnikoi (Gentiles), exploring their historical, theological, and cultural context. Results reveal that Jesus challenges the performative religiosity of His time, calling for personal and relational prayer that prioritizes quality over quantity. Theologically, this teaching introduces a profound understanding of God as a loving Father who knows human needs before they are spoken. This study highlights the relevance of Jesus' principles in overcoming modern challenges like digital distractions and performative spirituality. It concludes that authentic prayer is an act of faith, dependence, and love, fostering an intimate relationship with God. Abstrak: Doa merupakan inti dari kerohanian Kristen, namun esensinya sering kali dibayangi oleh formalisme, rutinitas, atau presentasi diri. Matius 6:6-7 memuat ajaran Yesus tentang doa, yang menekankan keintiman dan ketulusan sebagai dasar komunikasi dengan Tuhan. Kajian ini menggunakan metode hermeneutik dan linguistik untuk menganalisis istilah-istilah kunci seperti tameion (ruang privat), battalogeo (pengulangan yang sia-sia), dan ethnikoi (bangsa-bangsa lain), dengan mengeksplorasi konteks historis, teologis, dan budayanya. Hasilnya mengungkapkan bahwa Yesus menantang religiositas performatif pada zaman-Nya, menyerukan doa pribadi dan relasional yang mengutamakan kualitas daripada kuantitas. Secara teologis, ajaran ini memperkenalkan pemahaman yang mendalam tentang Tuhan sebagai Bapa yang penuh kasih yang mengetahui kebutuhan manusia sebelum kebutuhan itu diucapkan. Kajian ini menyoroti relevansi prinsip-prinsip Yesus dalam mengatasi tantangan modern seperti gangguan digital dan kerohanian performatif. Kajian ini menyimpulkan bahwa doa yang autentik adalah tindakan iman, ketergantungan, dan kasih, yang membina hubungan yang intim dengan Tuhan.
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Neidel, A., T. Gädicke, and S. Riesenbeck. "Metallurgical Failure Investigation of Fractured Dog Bone Seal Retainer Ring Fillet Welds in the Turbine Exhaust Casing of a Heavy-duty Gas Turbine Engine." Practical Metallography 58, no. 11 (2021): 715–24. http://dx.doi.org/10.1515/pm-2021-0063.
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Abstract Short fillet welds used to fasten a large retainer ring to so-called dog bone seals failed in the turbine exhaust casing of a non-OEM heavy-duty gas turbine engine used for power generation. The subject fillet welds fractured due to high cycle fatigue loading. Neither weld imperfections nor any other material defects were found that could have contributed to the failure. It was concluded that an unfavorable design, specifying very short fillet welds for fastening the dog bone seal segments to the retainer ring, was the root cause of failure. In a purely static loading situation, this design would probably not have failed. However, in a dynamic loading scenario as is the case in any gas turbine engine exhaust, such a design is simply not sturdy enough.
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Wei, Q. Y., Z. H. Wu, F. A. Ponce, J. Hertkorn, and F. Scholz. "Polarization effects in 2-DEG and 2-DHG AlGaN/AlN/GaN multi-heterostructures measured by electron holography." physica status solidi (b) 247, no. 7 (2010): 1722–24. http://dx.doi.org/10.1002/pssb.201046198.
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Debnath, Sudip. "Curing social maladies: Reading Juvenal’s Tenth Satire." International Journal of Multidisciplinary Research and Growth Evaluation 5, no. 2 (2024): 793–95. http://dx.doi.org/10.54660/.ijmrge.2024.5.2.793-795.
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“Poetry is, at bottom, a criticism of life”, says Matthew Arnold. We know that literature is not only a faithful artistic representation of life but also a medicine which cures the maladies of society. The purpose of correcting the wrongs in society is taken by some litterateurs to be great responsibility. They cannot accept the wrong way life is going. That is why they try to amend the errors committed by people. This practice is seen mainly in satirical works. In all literatures of all ages, there are plenty of writers who satirises the unjust social life. Chaucer’s Canterbury Tales; Alexander Pope’s The Rape of the Lock, An Epistle to Dr. Arbuthnot; Dryden’s Absalom and Achitophel, The Medal, Mac Flecknoe; Jonathan Swift’s Gulliver’s Travels — these are all satires representing critical commentaries on the follies and vices of the mentioned writers’ respective times. However, this trend of writing satires is not a new. If we dig deep into literary history we shall discover that this practice had been there also in ancient literary jargon. The names of Juvenal, Horace and so on may be referred to in this connection. In fact the later satirists carry deep influences from these classical writers who flourished during the reign of Augustus Caesar, the nephew of Julius Caesar. Among the notable literary figures who enlightened the age of Augustus Caesar in Rome, the one whose contribution is unavoidable is Juvenal. In this paper, we are going to have an analytical study on Juvenal’s Tenth Satire.
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Mutlu, Hatice, and Leonie Barner. "Teaching an Old Dog New Tricks: Sustainable Polymers." Macromolecular Chemistry and Physics 223, no. 13 (2022): 2200172. http://dx.doi.org/10.1002/macp.202200172.
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Hayati, Hasti, David Eager, and Paul Walker. "The effects of surface compliance on greyhound galloping dynamics." Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics 233, no. 4 (2019): 1033–43. http://dx.doi.org/10.1177/1464419319858544.
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Greyhounds are the fastest breed of dog and can reach a speed up to 68 km/h. These racing animals sustain unique injuries seldom seen in other breeds of dog. The highest rate of life-threatening injuries in these dogs is hock fracture, mostly of the right hind-leg. One of the main injury contributing factors in this sport is the track surface. There are some studies into the ideal track surface composition for greyhound racing but almost no study has investigated the body–surface interaction. Accordingly, the purpose of this work is to study the effect of surface compliance on the galloping dynamics of greyhounds during the hind-leg single-support phase which is a critical phase in hock injuries. Thus, a three degrees-of-freedom model for the greyhound body and substrate surface is designed using spring-loaded inverted pendulum method. The results showed that forces acting on the hind-leg were substantially affected when the surface compliance altered from the relatively hard (natural grass) to a relatively soft surface (synthetic rubber). The main contribution of this work is designing a mathematical model to predict the dynamics of the hock and the hind-leg as the most vulnerable body parts in greyhounds. Furthermore, this model can be used to optimise the greyhound track surface composition and therefore improve the safety and welfare within the greyhound racing industry.
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Utami, Sari. "PERUBAHAN STATUS LIFESTYLE KOMSUMTIF PEREMPUAN DALAM MENGGUNAKAN ONLINE SHOP." AN-NISA 11, no. 2 (2019): 483–500. http://dx.doi.org/10.30863/annisa.v11i2.334.
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The lifestyle of the Indonesian people has experienced the development of becoming more modern which is more practical and wants ease in all its activities. This study aims to explain and analyze changes in women's consumptive lifestyles in using online shops. This study uses descriptive qualitative research method, namely research that seeks to describe the object being examined and also dig up as much information as possible about the problem that is the topic of research based on facts that exist in the field, using key informants and informants as data sources. The data presented uses primary data and secondary data through in-depth interviews, field observations, references relating to this research and internet data. Data analysis in this study refers to the interactive analysis model of Matthew B. Miles and A. Michael Huberman. The results of this study that it can be concluded, Women in using online shops that have been active become increasingly consumptive in terms of shopping online to meet needs based on the desire to maintain appearance as a form of self-identity. The women used to buy items such as clothes, hijab, bags, shoes, cosmetics and accessories on an online shop on the basis of supporting the appearance to look beautiful and attractive, fulfilling a more trendy and current lifestyle, then buying the product because of the appearance of judgment that good products or high-priced products will create high self-esteem. They say that products that are purchased online all this time are their main need to maintain their appearance. But in reality unwittingly tends to be excessive and is an elaboration of understanding the theory of consumptive behavior.
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Zhang, Xiaofei, Xin Gao, Gaopeng Feng, and Dazhuan Xu. "BLIND JOINT DOA AND DOD ESTIMATION AND IDENTIFIABILITY RESULTS FOR MIMO RADAR WITH DIFFERENT TRANSMIT / RECEIVE ARRAY MANIFOLDS." Progress In Electromagnetics Research B 18 (2009): 101–19. http://dx.doi.org/10.2528/pierb09050603.
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Desai, Umang, Kléber Nicolet, Sukanya Prabhudesai, et al. "Stress tolerance of lightweight glass-free PV modules for vehicle integration." EPJ Photovoltaics 15 (2024): 10. http://dx.doi.org/10.1051/epjpv/2024003.
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Electric vehicles (EVs) currently dominate the sales in the automotive market. A big leap in this market can be made by developing a photovoltaic product that can be integrated to an EV, as it can boost the driving range of the EV while reducing the charging frequency. Such vehicle-integrated photovoltaic (VIPV) products are already successfully demonstrated, but they are usually made with glass as a front sheet – making them bulky and limiting their use to the car roofs due to safety reasons. The contemporary focus of the research in the field of VIPV is on developing a product that is lightweight (LW) and easily integrable into the complex shapes of an EV. Therefore, in this work, we present our initial findings on a novel architecture for LW VIPV modules employing polycarbonate (PC) as a front sheet. The mechanical behaviour of the LW module under bending is successfully simulated using finite elements (FE) modelling to predict the fracture of the solar cells, which can then be used as a predictive tool to check the maximal load on the PV body of an EV before cracking the c-Si solar cells. We demonstrate that a change in the temperature of the PC-based LW modules can modify the interspacing between the cells and thus create stress on the connectors. The dog-bone connectors are found to allow almost unconstrained movement of the cells in the module when subjected to variation of temperature. The cell movements may result in mechanical fatigue of the interconnection, which can ultimately result in disconnection of the cells. Initial performance of the dog-bone connectors is investigated by applying mechanical fatigue experiments, which demonstrate that the special geometry of the dog-bone connector could endure a greater number of thermal cycles than a simple prismatic shape would.
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Casado Ariza, Manuel José. "La cerámica con decoración grabada de época tartésica: estado actual de la cuestión." SPAL. Revista de Prehistoria y Arqueología de la Universidad de Sevilla, no. 10 (2001): 283–93. http://dx.doi.org/10.12795/spal.2001.i10.19.
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Han, J. C., Y. M. Zhang, and C. P. Lee. "Augmented Heat Transfer in Square Channels With Parallel, Crossed, and V-Shaped Angled Ribs." Journal of Heat Transfer 113, no. 3 (1991): 590–96. http://dx.doi.org/10.1115/1.2910606.
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The effect of the rib angle orientation on the local heat transfer distributions and pressure drop in a square channel with two opposite in-line ribbed walls was investigated for Reynolds numbers from 15,000 to 90,000. The square channel composed of ten isolated copper sections has a length-to-hydraulic diameter ratio of 20; the rib height-to-hydraulic diameter ratio is 0.0625; the rib pitch-to-height ratio equals 10. Nine rib configurations were studied: 90 deg rib, 60 and 45 deg parallel ribs, 60 and 45 deg crossed ribs, 60 and 45 deg ∨-shaped ribs, and 60 and 45 deg ∧-shaped ribs. The results show that the 60 deg (or 45 deg) ∨-shaped rib performs better than the 60 deg (or 45 deg) parallel rib and, subsequently, better than the 60 deg (or 45 deg) crossed rib and the 90 deg rib. The ∨-shaped rib produces the highest heat transfer augmentation, while the ∧-shaped rib generates the greatest pressure drop. The crossed rib has the lowest heat transfer enhancement and the smallest pressure drop penalty.
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Zhang, Xijun, Clifton L. Dalgard, and Matthew D. Wilkerson. "Abstract 3168: DE-meta: Revealing tumor gene expression by meta-analysis of RNASeq and proteomics datasets." Cancer Research 83, no. 7_Supplement (2023): 3168. http://dx.doi.org/10.1158/1538-7445.am2023-3168.
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Abstract Detecting differentially expressed genes under different biological conditions is crucial to characterize mechanisms of cancer development and identifying determinants of patient outcome. High throughput technologies such as RNA sequencing and mass spectrometry-based proteomics have been widely used to identify differentially expressed genes (DEG), on a transcript and on a peptide basis, respectively. However, both transcription and translation of genes provide information about gene expression. Thus, leveraging both RNA and protein expression data could potentially produce more accurate results. Various statistical tools have been developed to tackle the differential expression problem for a single platform, such as edgeR, DESeq2, etc. However, a tool that integrates both transcriptome and proteomics data for differential expression analysis has not yet been developed. Meta-analysis can potentially increase statistical power and generate a more consensus conclusion by combining multiple datasets. Here we present DE-Meta, a new tool developed using R, which performs combined meta-analysis of RNA-seq and MS-based proteomics on matched tumor specimens. To characterize the performance of our method using real world data, we utilized a published lung cancer dataset and set a truth standard of DEG between known two expression subtypes: terminal respiratory unit (TRU) and proximal proliferative (PP). Briefly, we restricted to 7,458 common genes detected by RNA-seq and MS-based proteomics. We then, randomly selected tumors as the truth sample set, n=20 TRU and n=20 PP tumors. With this truth sample set, DEGs were calculated separately by RNA or by protein, using DESeq2 and regression models. The union of these DEGs defined the truth DEG set. Using independent tumors (n=10 TRU and n=10 PP), we applied DE-meta to detect DEGs by RNA, by protein or joint RNA and protein data. Through receiver operating characteristic curve analysis, we show that the DE-meta joint model performed better than the single platform models (joint AUC=0.651, RNA AUC=0.610, protein AUC=0.623). Focusing genes relevant to tumor biology, we found that the DE-meta joint model called an 169 cancer-relevant DEGs, such as MSH2, CD4, WDR3, PIK3R1, and RPS6KA3. which were not detected by the RNA or protein models, at the same false discovery rate threshold of 0.05 (Benjamini-Hochberg procedure). In summary, our new DE-meta tool, by joint analysis of RNA-seq and MS-based proteomics datasets, yields more accurate and biologically-relevant results. The views expressed in this abstract are solely of the authors and do not reflect the official policy of the Departments of Army/Navy/Air Force, Department of Defense, USUHS, HJF, or U.S. Government. Citation Format: Xijun Zhang, Clifton L. Dalgard, Matthew D. Wilkerson. DE-meta: Revealing tumor gene expression by meta-analysis of RNASeq and proteomics datasets [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3168.
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Nakae, Setsu, Maho Kitamura, Daisuke Fujiwara, et al. "Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation." Acta Crystallographica Section F Structural Biology Communications 77, no. 12 (2021): 459–64. http://dx.doi.org/10.1107/s2053230x21011687.
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Eukaryotic protein kinases contain an Asp-Phe-Gly (DFG) motif, the conformation of which is involved in controlling the catalytic activity, at the N-terminus of the activation segment. The motif can be switched between active-state (DFG-in) and inactive-state (DFG-out) conformations: however, the mechanism of conformational change is poorly understood, partly because there are few reports of the DFG-out conformation. Here, a novel crystal structure of nonphosphorylated human mitogen-activated protein kinase kinase 1 (MEK1; amino acids 38–381) complexed with ATP-γS is reported in which MEK1 adopts the DFG-out conformation. The crystal structure revealed that the structural elements (the αC helix and HRD motif) surrounding the active site are involved in the formation/stabilization of the DFG-out conformation. The ATP-γS molecule was bound to the canonical ATP-binding site in a different binding mode that has never been found in previously determined crystal structures of MEK1. This novel ATP-γS binding mode provides a starting point for the design of high-affinity inhibitors of nonphosphorylated inactive MEK1 that adopts the DFG-out conformation.
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Xin, Renlong, Yang Leng, and Ning Wang. "Ultrastructure study of hydroxyapatite precipitation on ceramic surfaces in dog model." Materials Science and Engineering: C 28, no. 8 (2008): 1255–59. http://dx.doi.org/10.1016/j.msec.2007.11.006.
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Şincai, Mariana, Diana Gângǎ, Doina Bica, and Ladislau Vékás. "The antitumor effect of locoregional magnetic cobalt ferrite in dog mammary adenocarcinoma." Journal of Magnetism and Magnetic Materials 225, no. 1-2 (2001): 235–40. http://dx.doi.org/10.1016/s0304-8853(00)01263-4.
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Liu, Yang, Kai Zhong, Aiqiang Wang, et al. "Optical Terahertz Sources Based on Difference Frequency Generation in Nonlinear Crystals." Crystals 12, no. 7 (2022): 936. http://dx.doi.org/10.3390/cryst12070936.
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Terahertz (THz) sources, ranging from 0.1 THz to 10 THz, between microwaves and infrared waves, have important applications in spectral detection, medical imaging, communication, etc. Difference frequency generation (DFG) is an effective method for generating terahertz with the characteristics of low cost, simple structure, widely tunable range, no threshold, and room-temperature operation. This paper reviews various optical terahertz sources of difference frequency generation based on nonlinear crystals, including DFG with inorganic crystals, DFG with organic crystals, DFG with quasi-phase-matching (QPM) crystals, DFG in waveguides, cavity-enhanced DFG, and cascaded DFG. Their recent advances, as well as their advantages and disadvantages, are fully present and discussed. This review is expected to provide a comprehensive reference for researchers in this field and a quick understanding of optical THz sources of difference frequency generation with nonlinear crystals.
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Sanchez-Covarrubias, Alex P., Ramlogan Sowamber, Leah Dodds, Andre Pinto, Sophia George, and Matthew Schlumbrecht. "Abstract C052: Endometrial cancer genomics varies by race." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): C052. http://dx.doi.org/10.1158/1538-7755.disp22-c052.
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Abstract Introduction Variability in endometrial cancer (EC) risk and outcomes exist, with Black women disproportionately negatively affected related to White women. The biologic etiologies of these observations are poorly understood. Our objective was to describe the somatic mutations of the tumor genome and compare them to RNA expression in self-identified Black and White women diagnosed with EC. Methods Women with newly diagnosed EC and undergoing hysterectomy were recruited prospectively. Fresh tumors obtained at the time of surgery were flash-frozen, underwent DNA and RNA extraction and were submitted for whole exome sequencing (WES) analysis (DNA) or bulk RNA sequencing analysis. Differentially expressed genes between racial groups and tumor grade were calculated using Deseq2. Genomic ancestry was determined using ADMIXTURE. Chi-square and Mann Whitney U tests were used for analyses, with a threshold for significance of p&lt;0.05. Results A total of 49 patients with EC were included. Thirty (61.2%) women were diagnosed with low-grade EC and 19 (38.8%) with high grade EC. Twenty (40.8%) women self-identified as Black, 27 (55.1%) as White and 2 (4.1%) as Asian/other. Admixture analysis showed that 36 (73.4%) had &gt;14% African ancestry. The remaining 13 (26.5%) patients had admixed European and Native American ancestry, with &lt;1% African ancestry. In the RNA-seq, we found significant DEGs by tumor grade; with 2132 DEG in High grade compared to Low grade tumors with a false discovery rate of &lt;0.05 and a fold change (FC) of ≤-1.5 or ≥1.5. Top 10 DEG included MT4, TAF15, SLFN5 and PLEKHS1 (upregulated) and MCRIP1, MAZ, MYOM3, PRPH, BCL7C, AC016700.5 (downregulated). In the WES analysis, 8 Black women had mutations in GON4L compared to 1 in the White woman (44.4% vs 3.7%, padj=0.04); and 7 Black women had a mutation in PRAMEF14 compared to 1 White woman (38.8% vs 3.7%, padj= 0.06). Conclusion GON4L, which is a transcription factor associated with decreased apoptosis and promotion of tumor growth through CD24 regulation, was significantly more mutated in the EC genome of Black women relative to White women. Somatic mutation and transcriptional changes are seen between tumor grade and self-identified race and require further exploration for its relationship to aggressive disease. Citation Format: Alex P. Sanchez-Covarrubias, Ramlogan Sowamber, Leah Dodds, Andre Pinto, Sophia George, Matthew Schlumbrecht. Endometrial cancer genomics varies by race [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C052.
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Nemirovskii, S. K. "Statistical Signature of Vortex Filaments in Classical Turbulence: Dog or Tail?" Journal of Engineering Thermophysics 29, no. 1 (2020): 14–25. http://dx.doi.org/10.1134/s1810232820010026.
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Scheunert, G., V. Hoffmann, R. Kullock, et al. "Utilizing Dog-Boning to Build up High-Aspect-Ratio Nanofences." Journal of The Electrochemical Society 161, no. 1 (2013): D26—D30. http://dx.doi.org/10.1149/2.024401jes.
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AL-Hadhrami, Luai, Todd Griffith, and Je-Chin Han. "Heat Transfer in Two-Pass Rotating Rectangular Channels (AR=2) With Five Different Orientations of 45 Deg V-Shaped Rib Turbulators." Journal of Heat Transfer 125, no. 2 (2003): 232–42. http://dx.doi.org/10.1115/1.1561455.
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An experimental study was made to obtain heat transfer data for a two-pass rectangular channel (aspect ratio=2:1) with smooth and ribbed surfaces for two channel orientations (90 deg and 135 deg with respect to the plane of rotation). The V-shaped ribs are placed on the leading and trailing surfaces. Five different arrangements of 45 deg V-shaped ribs are studied. The Reynolds number and rotation number ranges are 5000–40000, and 0.0–0.21, respectively. The rib height to hydraulic diameter ratio (e/D) is 0.094; the rib pitch-to-height ratio (P/e) is 10; and the inlet coolant-to-wall density ratio (Δρ/ρ) is maintained around 0.115 for every test. The results show that the rotation-induced secondary flow enhances the heat transfer of the first pass trailing surface and second pass leading surface. However, the first pass leading and the second pass trailing surfaces show a decrease in heat transfer with rotation. The results also show that parallel 45 deg V-shaped rib arrangements produce better heat transfer augmentation than inverted 45 deg V-shaped ribs and crossed 45 deg V-shaped ribs, and a 90 deg channel orientation produces greater rotating effect on heat transfer than a 135 deg orientation.
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Pun, Matthew, Drew Pratt, and Sriram Venneti. "Abstract 6049: Identifying shared features of low-H3K27me3 pediatric brain tumors." Cancer Research 82, no. 12_Supplement (2022): 6049. http://dx.doi.org/10.1158/1538-7445.am2022-6049.
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Abstract Brain tumors have the worse survival rates of all childhood malignancies, and a better understanding of their biology is needed for therapeutic development. Two especially devastating subtypes of pediatric brain tumors—diffuse midline gliomas, H3K27M-mutant (DMGs) and posterior fossa ependymomas, group A (PFAs) are both characterized by a hallmark of global reduction of histone 3 lysine 27 trimethylation, a mark associated with transcriptional repression. DMGs primarily harbor mutations of histone 3 (H3K27M) that inhibit the function of the H3 methyltransferase enhancer of zeste homolog 2 (EZH2)-containing polycomb repressive complex (PRC2). Most PFAs overexpress EZH inhibitory protein (EZHIP), resulting in a similar effect on PRC2 activity. Intriguingly, a small subset of DMGs found to be lacking H3K27M mutations express EZHIP, and a fraction of histological PFAs lacking EZHIP expression harbor H3K27M mutations. Given the highly similar putative driving alterations and epigenetic features in these two tumor types, we undertook a systematic evaluation of the clinical and molecular features of each tumor class to elucidate additional shared features and potential targetable vulnerabilities. We performed detailed analyses of genomic aberrations, gene expression, and epigenomic landscapes to identify key similarities and differences in tumor biology. From preliminary studies, our findings demonstrate similar H3K27me3 landscapes with convergence of residual tri-methylated loci between PFA and DMG tumors. We additionally found shared recurrent copy number gain of the long arm of chromosome 1 (1q) and identified several 1q genes whose expression correlated with survival differences in cohorts of both tumors. Together, these findings better define the commonalities and differences of these highly aggressive, low-H3K27me3 pediatric brain tumors and will provide a framework for understanding which therapeutic strategies may translate from one tumor to the other. Citation Format: Matthew Pun, Drew Pratt, Sriram Venneti. Identifying shared features of low-H3K27me3 pediatric brain tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6049.
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Soritau, Ilie. "A Debate Concerning the Biblical Mode of Baptism." DIALOGO 7, no. 2 (2021): 157–65. http://dx.doi.org/10.51917/dialogo.2021.7.2.13.
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"Baptism inaugurates a life that daily moves forward to a battle, confident that in each sorrow, there is a more vigorous expression of the presence of the risen Christ. Baptism warns the Christian that if he shares the same life, he must face the same struggle of life unto death so that life is eternally victorious. Recent events in the Romanian Orthodox Church regarding the baptism of infants by immersion have ignited a civil debate and much criticism. The issue of baptism and for that matter, the baptism itself is very important. For the believers especially this is important. However, no matter how important this is, one has to agree that it should never ever lead to division and hate. Unfortunately, it looks like nothing among believers can lead to disagreement more than such discussions about the role of baptism, the meaning of it, and of course, the methods used to perform the baptism. On the other hand, there should be an agreement that ignoring the problems raised by this issue will not solve it at all, but instead creating even more problems and further the gap among many Christians, ultimately. The fact that there is a possibility to discuss this important doctrine as part of a dialog among many denominations, among many religions it will prove the level of one’s maturity to “agree to disagree” with the main goal of learning always and know what to stand for and what is worth fighting for. When it comes to major doctrines special attention should be given to the text, making sure that there is a proper, correct, throughout exegesis as well as a very good lexical and syntactical study. The purpose of this research is to dig deep into the Bible and more specifically exegete the text found in The Gospel of Matthew chapter 3, from verses 13 to 17, then view its theological lessons followed by practical applications."
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Muley, A., R. M. Manglik, and H. M. Metwally. "Enhanced Heat Transfer Characteristics of Viscous Liquid Flows in a Chevron Plate Heat Exchanger." Journal of Heat Transfer 121, no. 4 (1999): 1011–17. http://dx.doi.org/10.1115/1.2826051.
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Steady-state heat transfer and pressure drop data for single-phase viscous fluid flows (2 ≤ Re ≤ 400) in a single-pass U-type counterflow plate heat exchanger (PHE) with chevron plates are presented. With vegetable oil as test fluid (130 < Pr < 290), three different plate arrangements are employed: two symmetric (β = 30 deg/30 deg and 60 deg/60 deg) and one mixed (β = 30 deg/60 deg). The effects of chevron angle β, corrugation aspect ratio γ, and flow conditions (Re, Pr, μ/μw on Nu and f characteristics of the PHE are delineated. The results show a rather complex influence of plate surface corrugations on the enhanced thermal-hydraulic behavior. Relative to the performance of equivalent flat-plate packs, chevron plates sustain up to 2.9 times higher heat transfer rates on a fixed geometry and constant pumping power basis, and require up to 48 percent less surface area for the fixed heat load and pressure drop constraint.
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Azuonwu, Obioma1* Ihua Nnenna1 and Ahiakwo Christian2. "Antibiogram Pattern of Potential Pathogenic Bacteria Associated with Domestic Dog Faecal Matter in Port Harcourt Metropolis." Journal of Biomedical Research & Environmental Sciences 1, no. 2 (2020): 039–47. https://doi.org/10.37871/jels1118.
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This study was aimed at investigating the Antibiogram pattern of Potential Pathogenic Bacteria that are associated with Domestic dog faecal matter in Port Harcourt Metropolis. Convenient sampling techniques were explored for sample collection. A total of fifty samples were collected from domestic dogs from different locations (Agip estates, Rumuokoro, GRA, Sandfill, Town, RSU lecturers’ quarters) within Port Harcourt metropolis, Rivers State, Nigeria. The bacteriological analysis was determined using standard microbiological procedures and identification techniques. Potential pathogens associated with domestic dog faecal matter that were isolated include; Escherichia coli, Klebsiella species, Pseudomonas species, Proteus species, Bacillus species, Staphylococcus aureus and Streptococcus species. However other species of Staphylococcus were also isolated respectively. The study showed that among the seven antibiotics used, tarivid was the most sensitive (96%), while peflacin was the most resistant (62%). The correlation analysis showed the relationship between isolates and bacterial count with antibiogram revealed that only Ciproflaxacin showed significant correlation with the isolates (r = 0.322, p = 0.02). This study strongly suggests that domestic dogs carry potential pathogenic organisms present in the faecal matter that can serve as sources of infection to the pet owners, especially the strains showing resistance to antibiotics. These pose a community health threat, thus putting the general public at risk of contracting infections. It is, therefore, important that these domestic dogs including the ones used as pets should be treated and possibly vaccinated frequently, even as faecal matter from domestic dogs should be well disposed to prevent possible zoonotic infections to man from the contaminated environmen
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Garcia-Pino, Abel, Minh-Hoa Dao-Thi, Ehud Gazit, Roy David Magnuson, Lode Wyns, and Remy Loris. "Crystallization of Doc and the Phd–Doc toxin–antitoxin complex." Acta Crystallographica Section F Structural Biology and Crystallization Communications 64, no. 11 (2008): 1034–38. http://dx.doi.org/10.1107/s1744309108031722.
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Hui, David, and I. H. Y. Du. "Initial Postbuckling Behavior of Imperfect, Antisymmetric Cross-Ply Cylindrical Shells Under Torsion." Journal of Applied Mechanics 54, no. 1 (1987): 174–80. http://dx.doi.org/10.1115/1.3172954.
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This paper deals with the initial postbuckling of antisymmetric cross-ply closed cylindrical shells under torsion. Under the assumptions employed in Koiter’s theory of elastic stability, the structure is imperfection-sensitive in certain intermediate ranges of the reduced-Batdorf parameter (approx. 4 ≤ ZH ≤ 20.0). Due to different material bending-stretching coupling behavior, the (0 deg inside, 90 deg outside) two-layer clamped cylinder is less imperfection sensitive than the (90 deg inside, 0 deg outside) configuration. The increase in torsional buckling load due to a higher value of Young’s moduli ratio is not necessarily accompanied by a higher degree of imperfection-sensitivity. The paper is the first to consider imperfection shape to be identical to the torsional buckling mode and presents concise parameter variations involving the reduced-Batdorf paramter and Young’s moduli ratio.