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Dissertations / Theses on the topic 'Metabolic Complications'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Valk, Marc van der. "Metabolic complications of antiretroviral therapy." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/69542.

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Rodie, Vanessa Angela. "Metabolic complications of pregnancy and cardiovascular disease risk." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421118.

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3

Lam, Chung-mei Jamie. "Obstructive sleep apnea and cardiometabolic complications." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085854.

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4

Bailey, Swneke. "Genetic insights into obesity and its associated metabolic complications: a multiethnic perspective." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104623.

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Obesity has become one of the biggest threats to global health, as it frequently co-occurs with a constellation of type 2 diabetes (T2D) and cardiovascular disease (CVD) risk factors and is associated with increased mortality. Genetic factors account for a substantial portion of the phenotypic variance in obesity and each of the correlated vascular disease risk factors. In this thesis, I describe the identification of several common genetic variants that predispose carriers to the complications associated with obesity. First, I report the identification of common variation within the gene of a

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5

Das, Amitava. "Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458.

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6

Lo, Che Sam, and mikewood@deakin edu au. "Relationship of nutritional and metabolic factors to non-invasive, indices of macrovascular disease in diabetes." Deakin University. School of Sciences, 1986. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051208.122550.

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Factors which may account for the high frequency of macrovascular disease in diabetics are age, sex, cigarette smoking, hypertension, obesity, lack of exercise, diet, hyperglycaemia, hyperinsulinaeroia, hypercholesterolaemia, hypertriglyceridaemia, low HDL-cholesterol concentration, elevated free fatty acid concentration and enhanced platelet aggregation. Twenty seven (13 men and 14 women) non-insulin-dependent diabetics and thirty eight age, height and weight matched healthy subjects (10 men and 28 women) were studied. None of the subjects were smokers, or hypertensive. No subject had any cli

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Abrahams, Zulfa. "Metabolic complications resulting from the use of antiretroviral therapy in HIV-infected patients." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22947.

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While antiretroviral therapy (ART) has extended the life expectancy of those infected with HIV, it is also associated with a number of metabolic complications, such as dysglycaemia, insulin resistance and lipodystrophy. Lipodystrophy is characterised by an increase in trunk fat (lipohypertrophy) and/or a decrease in limb fat (lipoatrophy). This thesis investigates the metabolic complications associated with ART, and develops simple anthropometric cut-points for identifying those with lipodystrophy. Data for this thesis comes from three datasets (a cross sectional study and two longitudinal stu

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8

Haro, Barceló Júlia. "Genetic and metabolic alterations in maternal and paternal one carbon metabolism and development of pregnancy complications of placental origin." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670244.

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Les complicacions durant l’embaràs derivades de problemes en la placenta, incloent hipertensió gestacional (HG) i retard del creixement intrauterí (CIR), posen la salut de la mare i del nadó en risc. Un mal estat del metabolisme monocarbonat de la mare i un estil de vida poc saludable poden derivar en complicacions de l’embaràs. Els polimorfismes comuns MTHFR 677C>T i SLC19A1 80G>A estan associats amb un estat pobre en folats i nivells alts d’homocisteïna plasmàtica (tHcy). Factors paterns poden contribuir a una mala placentació, arrel d’una invasió insuficient del trofoblast i una remodelació

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Lam, Chung-mei Jamie, and 林頌眉. "Obstructive sleep apnea and cardiometabolic complications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085854.

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10

Ross, Ian Louis. "The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10862.

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Includes abstract.<br>Includes bibliographical references.<br>This thesis aimed to address a number of unanswered research questions in Addison's Disease: investigate whether autoimmunity is the predominant cause of Addison's disease in South Africa and if a human leukocyte (HLA) DQ antigen association exists; the extent to which lipids, lipoproteins and biochemical markers of cardiovascular disease are abnormal; the degree to which replacement doses of hydrocortisone are supra-physiological; the impact of glucocorticoid receptor (GCR) polymorphisms on risk factors, markers of card

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Sahu, Soumyadip. "Cross-talk of Leptin and Thrombospondin-1 in Atherosclerotic Complications." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1492525184445034.

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12

Fritz, Kathleen Gary. "Development of a urinary metabolic ratio that reflects systemic theophylline elimination during pregnancy." Scholarly Commons, 1993. https://scholarlycommons.pacific.edu/uop_etds/2245.

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A number of studies have investigated the natural history of asthma in pregnancy. Most of the data suggests that the course of asthma for a given patient is unpredictable. Turner, et al.7 summarize the data from all of the English-language literature of studies on the effect of pregnancy on astha. Of 1054 cases examined, 49% of the asthma conditions remained unchanged, 22% got worst and 29% became better.7 Theophylline has been used safely during pregnancy. A review of the literature by O'Brien, showed that no teratogenic effects were associated with the use of theophylline in 117 cases and am

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13

Axelsson, Jonas. "Fat tissue, adipokines and clinical complications of chronic kidney disease /." Stockholm : Department of Clinical Science, Intervention and Technology, Divisions of Renal Medicine and Baxter Novum, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-653-0/.

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14

Sinxadi, Phumla Z. "Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20329.

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BACKGROUND: Antiretroviral therapy (ART), notably efavirenz and lopinavir, have been associated with metabolic abnormalities known to increase cardiovascular risk. Efavirenz and lopinavir pharmacokinetics demonstrate considerable interindividual variability, which in part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of antiretroviral drugs, and their associations with metabolic complications, are incompletely understood. We explored asso

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15

Hayes, Philip Michael. "Ethnic-specific associations between abdominal and gluteal fat distribution and the metabolic complications of obesity : implications for the use of liposuction." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/12235.

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Includes bibliographical references.<br>More than three-quarters (77%) of the 40.5 million people living in South Africa are black African, of which more than 40% are urbanised. Black African women living in urban areas have a significantly higher prevalence (62%) of overweight than urban black males (28%) or white females (53%). It was previously thought that obesity in black South African women was not associated with deleterious metabolic sequelae and was termed "healthy" obesity...

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McHarg, Winsome Joy. "A study of the interrelationship between grip strength, muscle mass, metabolic utilisation of fat and surgical outcome in patients undergoing stomach and bowel surgery." Thesis, Queensland University of Technology, 1994. https://eprints.qut.edu.au/37192/1/37192_McHarg_1994.pdf.

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Numerous investigators have demonstrated a relationship between pre and postoperative hyperketonaemia and nitrogen sparing. Grip strength has recently been found to be a sensitive indicator of post-operative complications. The aims of this study were: 1) To determine whether a relationship exists between perioperative ketone status and nitrogen status and post-operative grip strength; 2) to investigate the relationship between perioperative ketone status and other factors including cancer and surgery; 3) to determine which parameters used in this study are associated with increased length of

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17

Rajaobelina, Kalina. "Autofluorescence cutanée des produits de glycation avancée (AGE), mémoire métabolique et complications du diabète." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0256/document.

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Dans un contexte de vieillissement de la population et d’accroissement des maladies chroniques liées à l’âge comme le diabète, de nouveaux biomarqueurs de l’état de santé à long terme doivent être étudiés. Les produits de glycation avancée (AGE) sont des molécules témoins de la charge métabolique accumulée au cours du temps, dénommée "mémoire métabolique". Les AGE jouent un rôle important dans les lésions à long terme dans le diabète et dans le déclin du métabolisme global lié au vieillissement. L’accumulation cutanée des AGE peut être mesurée par autofluorescence (AF) de manière instantanée e

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18

Lee, Angela. "Type 1 Diabetes with Metabolic Syndrome Features: Exploring this Modern-Day Phenotype and the Effects of High-Intensity Interval Training." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/24555.

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Introduction Type 1 diabetes is characterised by insulin deficiency, however the ‘double diabetes’ phenotype of type 1 diabetes with insulin resistance and/or metabolic syndrome is becoming increasingly recognised, especially given rising global obesity rates. The effects of exercise on metabolic health have not been adequately studied in people with type 1 diabetes, and exercise-related hypoglycaemia is a major barrier. Aims This thesis aimed to examine the prevalence of metabolic syndrome in adults with type 1 diabetes, and its association with diabetes complications. The safety and be

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Ingberg, Claes-Mårten. "Type 1 diabetes mellitus: Aspects of long-term complications and body composition." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3287.

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<p>Studies concerning social consequences, gastrointestinal and urinary tract symptoms were conducted in a population-based cohort comprising patients with long-standing type 1 diabetes and matched control persons. Three different questionnaires were sent by mail to diabetic patients and control persons. After a mean duration of 28.7±2.6 years, compared to the controls the diabetic patients showed an almost 10 times higher mortality, a lower employment rate and greater need for welfare benefits. These differences were mainly due to diabetic late complications. Education, housing conditions, li

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Macchini, Luisa. "the effects of GLP-1 on SIRT1 and on the related metabolic pathways in vascular endothelial cells: potential effects on vascular injury in diabetic patients." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3421971.

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Background: Incretin therapy may have a potential protective role in the treatment of diabetes associated with the cardiovascular comorbidities. GLP-1 may have beneficial effects in the endothelium and in the cardiac tissue although the molecular mechanisms by which GLP-1 exerts these actions are still unknown. Recently, it has been demonstrated that SIRT1, a NAD’+ deacetylase protein, has a protective role on vascular damage in diabetes by reducing oxidative stress. In several cells and in animal models of diabetes SIRT1 gene expression is reduced. Therefore, SIRT1 may represent a new therape

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21

Zimmerman, Angela D. "Nursing interventions in the care of patients undergoing induced hypothermia." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/531.

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Use of induced hypothermia for the purpose of lowering intracranial pressure and preserving neuronal function has increased as research data reveals a trend of positive outcomes in patients treated with this therapy. Recently induced hypothermia following cardiac arrest due to ventricular fibrillation has been deemed successful. Current research has expanded to evaluate the effectiveness of induced hypothermia as a treatment modality for severe stroke and head trauma. In spite of its efficacy, complications exist with this treatment modality. The purpose of this literature review is to examine

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22

Dertkigil, Sergio San Juan 1975. "Avaliação por imagem da distribuição da gordura corporal em obesos e suas correlações metabolicas." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311218.

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Orientador: Mario Jose Abdalla Saad<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T14:59:49Z (GMT). No. of bitstreams: 1 Dertkigil_SergioSanJuan_M.pdf: 2116703 bytes, checksum: 70e0c18a251483a0c4be5861dc3adee8 (MD5) Previous issue date: 2006<br>Resumo: Introdução A obesidade tem sido considerada uma das mais importantes doenças da atualidade, tanto pela sua crescente prevalência quanto pela sua alta relevância de morbi-mortalidade. A segmentação da gordura em seus diferentes compartimentos vem ganhando im

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23

Santos, Guilherme Spadini dos. "Estudo prospectivo da evolução de parâmetros relacionados à síndrome metabólica em pacientes ambulatoriais com transtorno de pânico tratados com clomipramina, fluoxetina ou placebo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-17022009-104821/.

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O desenvolvimento de síndrome metabólica como decorrência do uso de psicofármacos vem recebendo grande atenção da literatura nos últimos anos. O uso de antipsicóticos atípicos foi fortemente associado a ganho de peso, desenvolvimento de diabetes tipo 2 e aumento da mortalidade em pacientes esquizofrênicos. Já o uso de antidepressivos, embora associado a alterações de peso, não foi suficientemente estudado quanto ao risco de desenvolvimento de síndrome metabólica. Este estudo objetivou investigar alterações do peso corporal e de parâmetros relacionados à síndrome metabólica em pacientes com tra

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24

Milbank, Edward. "Extracellular vesicles as a therapeutic strategy to prevent or reverse obesity and its metabolic complications in the field of nanomedicine Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity Microparticles from apoptotic RAW 264.7 macrophage cells carry tumour necrosis factor-a functionally active on cardiomyocytes from adult mice." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0074.

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A ce jour, les thérapies anti-obésité restent limitées. De récente études ont fourni des résultats prometteurs en démontrant une diminution du poids de la souris via une injection stéréotaxique d’une forme dominante négative de l’AMPK (AMPK DN) directement dans le noyau ventromédial hypothalamique (VMH). Cependant, le potentiel thérapeutique de cette thérapie génique se voit entravé par une libération non spécifique de l’AMPK suite à une injection intraveineuse, plus adaptée à une approche clinique. Nous avons donc développé une approche de « nanobiomédecine » en utilisant des exosomes - nanov

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25

Käräjämäki, A. (Aki). "Non-alcoholic fatty liver disease (NAFLD):perspectives to etiology, complications and lipid metabolism." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526217376.

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Abstract Obesity, insulin resistance, type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) form a dangerous quartet which threatens human health all over the world. About 25% of adults around the world have NAFLD, which poses risks for cardiovascular and metabolic well-being and may develop into liver cirrhosis and hepatocellular carcinoma. Apart from lifestyle modification, treatment options for NAFLD are scarce. This thesis presents atrial fibrillation (AF) as a new complication of NAFLD among general population of 958 individuals aged 40-60 years participating in the OPERA st

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Xiang, Hong. "Alpha₁-adrenoceptor-mediated phosphoinositide breakdown and inotropic responses in right ventricles of streptozotocin-diabetic rats." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31036.

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The morbidity of and the mortality from cardiac disease are higher in diabetic patients. Clinical and experimental evidence suggests that diabetes-induced changes at the level of myocardium can, at least partially, contribute to these cardiac problems. The mechanism(s) involved in this diabetic cardiomyopathy is still unclear, but one defect appears to occur in the alpha₁-adrenoceptor system. Altered myocardial sensitivity and responsiveness to alpha₁-adrenoceptor agonists have been reported in experimental diabetes mellitus. Stimulation of alpha₁-adrenoceptors is known to produce a positive i

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Sotillo, Rodríguez Fernando. "Pathophysiology of immune-related complications in Lysinuric Protein Intolerance." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/463008.

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Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino acids, which drives a deficit in the functioning of the urea cycle due to the reduction levels of arginine and ornithine in plasma. Nevertheless LPI patients also develop immune and hematologic complications such as anemia, pulmonary alveolar proteinosis or hemophagocytic lymphohistiocytosis. However the molecular mechanism(s) and/or the initiation events that trigger the development of LPI immune

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28

Sun, Jihan. "Hepatocellular carcinoma complicating MASLD : metabolomic, lipidomic and gene expression analyses of tumorous and non-tumorous liver." Electronic Thesis or Diss., Besançon, Université Marie et Louis Pasteur, 2025. http://www.theses.fr/2025PAST3001.

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Le carcinome hépatocellulaire (CHC) peut compliquer une hépatopathie chronique d'origine virale, alcoolique ou une stéatopathie métabolique (MASLD), une affection qui touche 25 % de la population mondiale et dont l'incidence augmente. Bien que le CHC se développe habituellement en cas de cirrhose, 25 à 30 % des patients atteints de CHC sur MASLD (CHC-MASLD) ne présentent aucune fibrose ou une fibrose légère, ce qui suggère que différents mécanismes de cancérogénèse sont impliqués dans le CHC-MASLD. Notre étude s'est concentrée sur les analyses de lipidomiques et d'expression génique entre les

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Manning, Katherine L. "The influence of hormone suppression therapy and related factors on bone mineral density in cancer patients." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1399326.

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Cancer-treatment-induced bone loss (CTBL) is a well-recognized co-morbidity that affects many cancer patients. Commonly used to treat breast and prostate cancer patients, hormone suppression therapy (HST) may accelerate bone loss, resulting in osteopenia or osteoporosis. Because of their broad clinical utility, lifestyle and dietary modifications, such as regular participation in bone-stressing exercise and calcium supplementation, are starting to play a much larger role in the prevention and treatment of CTBL. However, only limited information is available on the effects that these factors ma

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Cheng, Wing-tim, and 鄭永添. "Polyol pathway contributes to hyperglycemia-induced cardiac dysfunction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508622.

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31

InesTagliapietra, Joelma. "Efeito da Sitagliptina nos potenciais evocados (somato-sensitivo e visual) e no controle metabÃlico do diabetes mellitus tipo 2." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4937.

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nÃo hÃ<br>Diabetes mellitus (DM) Ã uma sÃndrome associada a secreÃÃo de insulina deficiente, resistÃncia Ã aÃÃo da insulina ou uma associaÃÃo de ambas. Caracteriza-se por hiperglicemia crÃnica que a longo prazo poderÃ causar retinopatia, nefropatia, neuropatia perifÃrica e autonÃmica. Este estudo do tipo intervencionista, prospectivo e aberto teve como objetivo avaliar a eficÃcia terapÃutica da sitagliptina no controle metabÃlico do diabetes mellitus do tipo 2 recentemente diagnosticado (menos de seis meses) e nas vias de conduÃÃo nervosa somato-sensitiva e visual. Antes de iniciar o tratament

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Carr, Timothy Perry. "Copper deficiency-induced hypercholesterolemia: In vivo catabolism of high density lipoprotein cholesteryl ester and protein moities in the rat." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184690.

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Two studies were conducted to determine how HDL cholesteryl ester and apoprotein catabolism might contribute to the observed hypercholesterolemia of copper-deficient rats. Weanling male Sprague-Dawley rats were divided into two dietary treatments; copper-adequate (control, 5-7 mg Cu/kg diet) and copper-deficient (0.6-0.8 mg Cu/kg diet). Deionized water and diet were provided ad libitum. Dietary copper deficiency resulted in enlarged intravascular pools of HDL cholesteryl esters and total protein. HDL were isolated from rats of both treatment groups, radiolabeled, and injected into animals of t

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Vánky, Farkas. "Surgery for aortic stenosis : with special reference to myocardial metabolism, postoperative heart failure and long-term outcome /." Linköping : Linköpings universitet, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7471.

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Fonseca, Sonya G. "Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/414.

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The endoplasmic reticulum (ER) is a multi-functional cellular compartment that functions in protein folding, lipid biosynthesis, and calcium homeostasis. Perturbations to ER function lead to the dysregulation of ER homeostasis, causing the accumulation of unfolded and misfolded proteins in the cell. This is a state of ER stress. ER stress elicits a cytoprotective, adaptive signaling cascade to mitigate stress, the Unfolded Protein Response (UPR). As long as the UPR can moderate stress, cells can produce the proper amount of proteins and maintain a state of homeostasis. If the UPR, however, is

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Decoin, Raphaël. "Impact de la stéatohépatite non alcoolique sur le remodelage myocardique et sur les complications cardiovasculaires." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2023/2023ULILS066.pdf.

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Le remodelage cardiaque est un phénomène physiopathologique au cours duquel le muscle cardiaque est altéré au niveau structurel, i.e. tissulaire et cellulaire, et fonctionnel. Les implications cliniques sont diverses, notamment avec le développement de fibrillation atriale ou d'insuffisance cardiaque. Parmi les nombreux facteurs de risque identifiés, les Non-Alcoholic Fatty Liver Diseases (NAFLD) ont un rôle émergeant. Ces maladies hépatiques, caractérisée par une stéatose, une inflammation et une fibrose, est associée au développement de pathologies du myocarde.Dans ce travail, nous posons l’

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Rojas-Rodriguez, Raziel. "Adaptations of Adipose Tissue Expandability in Gestation are Associated with Maternal Glucose Metabolism." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1048.

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Pregnancy induces maternal metabolic adaptations including mild glucose intolerance and weight gain in order to support fetal development and lactation. Adipose tissue (AT) function in gestation is featured by reduced insulin sensitivity and fat mass accrual which partly accounts for the weight gain in pregnant women and adaptation of glucose metabolism. A common metabolic pregnancy complication is gestational diabetes mellitus (GDM), a disease characterized by impaired glucose tolerance with onset in gestation. However, the relationship between AT expandability and glucose metabolism in gesta

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Bubliauskaitė, Modesta. "Cukrinis diabetas ir asmens fizinis aktyvumas." Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130910_132617-21074.

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Tyrimo objektas: Cukriniu diabetu sergančių asmenų fizinio aktyvumo ir jo metabolizmo (medžiagų apykaitos) ekvivalento kategorija. Problema: Esant gana prieštaringiems tyrimų duomenims ir rekomendacijoms dėl fizinių pratimų, treniruočių, mankštos intensyvumo ir apimties sergantiems I ir II tipo cukriniu diabetu, ir egzistuojant nuostatai, jog diabetas yra viena iš 10-ties svarbiausių nedarbo priežasčių pasaulyje, iškyla probleminiai klausimai: 1) ar tikrai visada diabetas ir/ar jo tipas riboja sergančiųjų fizinės veiklos aktyvumą bei jo metu suaktyvinta medžiagų apykaitą kasdieniniame gyvenime

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Eira, Margareth da. "\"Alterações na função renal em pacientes HIV/AIDS tratados com esquemas terapêuticos incluindo indinavir\"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-10052005-150439/.

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Complicações renais e urológicas incluindo nefrolitíase, cristalúria, cólica renal e lombalgia, são eventos adversos bem conhecidos do indinavir (IDV), um inibidor de protease (IP) largamente utilizado no tratamento de pacientes infectados com o vírus da imunodeficiência humana (HIV). Prévios estudos em ratos demonstraram que o IDV, um potente IP capaz de provocar uma sustentada supressão da carga viral do HIV, induz vasoconstricção renal, diminui a filtração glomerular (RFG) e reduz a excreção urinária de nitrito (NO2-), sugerindo que a vasoconstricção causada pelo IDV deve ser mediada pelo ó

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Tholance, Yannick. "Suivi du métabolisme énergétique cérébral chez les patients victimes d'hémorragies sous-arachnoïdiennes graves : intérêt pour le pronostic individuel et le diagnostic des complications ischémiques." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10232/document.

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L'intérêt du suivi du métabolisme énergétique cérébral dans la prise en charge des patients victimes d'hémorragie sous-arachnoïdienne anévrismale (aSAH) grave reste actuellement controversé en raison de l'absence de valeurs seuils décisionnelles applicables en pratique. Ce travail avait pour objectif de réévaluer l'intérêt des paramètres biochimiques de trois techniques, la microdialyse intracérébrale (cMD), la mesure de la pression tissulaire cérébrale en oxygène (PbtO2) et le cathéter rétrograde jugulaire, pour prédire l’issue fonctionnelle de ces patients et diagnostiquer la survenue d'un i

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Knock, Erin Heather 1981. "Long-term dietary folate deficiency and intestinal tumor development in mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115689.

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Epidemiological evidence linking dietary folate deficiency and risk for colorectal cancer is conflicting. Studies using animal models indicate that timing, dose and presence of pre-malignant lesions will influence whether folate deficiency prevents or promotes tumor formation. In this thesis a new model of spontaneous tumor formation due to long-term dietary folate deficiency alone, in non-transgenic mice and without carcinogen induction, is developed. The mechanisms by which folate deficiency might influence cancer risk are also examined.<br>BALB/c mice, with or without a null allele in a key

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Hortencio, Taís Daiene Russo 1982. "Nutrição parenteral = complicações metabólicas em pacientes pediátricos e mudanças na prática clínica em pacientes domiciliares no Canadá = Parenteral nutrition: metabolic complication in pediatric patients hospitalized patients and changes in clinical practice in home patients in Canada." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308376.

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Orientadores: Antonio Fernando Ribeiro, José Roberto Negrão Nogueira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-28T09:12:18Z (GMT). No. of bitstreams: 1 Hortencio_TaisDaieneRusso_D.pdf: 2122387 bytes, checksum: 6b337a8713273a2fcc11dbc17230038f (MD5) Previous issue date: 2015<br>Resumo: Introdução O desenvolvimento da nutrição parenteral (NP) na década de 1960 e sua subsequente utilização na prática clínica tem tido um enorme impacto sobre os pacientes com numerosas doenças para as quais a nutrição foi impossív

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Tran, Hoang V. "Ventricular Arrhythmias Complicating Coronary Artery Disease: Recent Trends, Risk Associated with Serum Glucose Levels, and Psychological Impact." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/980.

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Introduction: Ventricular arrhythmias (VAs) are common after an acute coronary syndrome (ACS) and are associated with worse clinical outcomes. However, little is known about recent trends in their occurrence, their association with serum glucose levels, and their psychological impact in ACS setting. Methods: We examined 25-year (1986-2011) trends in the incidence rates (IRs) and hospital case-fatality rates (CFRs) of VAs, and the association between serum glucose levels and VAs in patients with an acute myocardial infarction (AMI) in the Worcester Heart Attack Study. Lastly, we examined the re

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Nigro, Julie. "The role of PPAR-α ligands (fibrates) in the regulation of vascular smooth muscle proteoglycan synthesis and structure as a contributor to reduced lipoprotein binding and the development of atherosclerosis". Monash University, Dept. of Medicine, 2004. http://arrow.monash.edu.au/hdl/1959.1/5464.

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Tijani, Omolara Khadijat. "Glucocorticoids and Intracrine Cortisol Metabolism in human Islets : Impact on Glucose Stimulated Insulin secretion." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS061.

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Une exposition excessive aux glucocorticoïdes (GC), comme observée chez les patients recevant une corticothérapie, peut entraîner un dysfonctionnement des cellules β et un diabète chez jusqu'à 40% des patients. Dans l'obésité, une surexposition locale au cortisol secondaire à une altération du métabolisme du cortisol contribue à l'apparition du diabète. Des doses élevées de GC comme la dexaméthasone (DEX) inhibent la sécrétion d'insuline stimulée par le glucose (SISG), mais les effets de doses plus faibles et des autres GC, tels que l'hydrocortisone (HC) et la prednisone (PRED), restent peu ét

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Singh, Dhruvaraj Kailashnath. "Clinical studies in diabetic vasculopathy to assess interactions between blood, bone and kidney." Thesis, University of Hertfordshire, 2010. http://hdl.handle.net/2299/4186.

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Diabetic vasculopathy (DV) is the most important consequence of chronic hyperglycemia in patients with diabetes mellitus (DM). This thesis explores the interaction of blood, bone and kidney in the pathogenesis of DV by i) reviewing the current understanding of pathogenesis of macrovascular and microvascular diseases in DM to identify gaps in literature and generate hypotheses relating to various facets of DV ii) undertaking a series of prospective studies to examine these hypotheses iii) analysing the findings and integrating any new information obtained from the clinical studies into the curr

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Junior, José Ricci. "Polimorfismo do exon 20 do gene da elastina em indivíduos portadores de doença diverticular dos cólons." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-13102014-100043/.

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A doença diverticular dos cólons (DDC) é relacionada à civilização, industrialização e à dieta. Estudos fisiológicos demonstraram que uma pressão intraluminal elevada, bem como alterações estruturais adquiridas da parede intestinal parecem ser fator decisivo, que se intensificam com o envelhecimento. Estas alterações podem ser causadas por alterações no tecido muscular e tecido conjuntivo relacionados ao metabolismo do colágeno e elastina, que presumivelmente pode ser geneticamente determinada. Sabe-se que pacientes com desordens genéticas do gene da elastina (ELN), como a estenose aórtica sup

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Legouis, David. "Altération de la néoglucogenèse rénale lors de l’insuffisance rénale aiguë." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS055.

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L’insuffisance rénale aiguë (IRA), quelle qu’en soit sa cause, est fortement associée à la mortalité. Le rein contribue jusqu’à 40 % de la production endogène de glucose à travers la néoglucogenèse, particulièrement pendant les conditions de jeûne de stress. Jusqu’alors, aucune étude ne s’était intéressée au comportement de cette fonction métabolique au cours d’un épisode d’IRA. Cette étude montre que la synthèse de glucose et l’utilisation du lactate sont altérées à la fois chez l’homme, en recourant au cathétérisme artérioveineux rénal chez des patients bénéficiant d’une intervention de chir

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Júnior, Carlos Kiyoshi Furuya. "Efeitos da cirurgia de Fobi-Capella na doença hepática gordurosa não alcoólica (DHGNA): estudo prospectivo de dois anos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-31102006-142922/.

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Introdução: A incidência de obesidade é crescente e alarmante, principalmente no mundo ocidental. De acordo com o National Center for Health Statistics, cerca de 61% da população adulta nos Estados Unidos está acima do peso e 30% é obesa, sendo que 5 a 6% está classificada na faixa de obesidade Grau III. No Brasil, o Ministério da Saúde aponta que 32,9% dos brasileiros estão fora da faixa de peso ideal, e 4,8% dos homens e 11,7% das mulheres encaixam-se na faixa de obesidade Grau III. Devido a alta prevalência da Doença Hepática Gordurosa Não Alcoólica (DHGNA) em pacientes portadores de obesid

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Filho, Filadelfo Rodrigues. "Nova técnica para pesquisa de viabilidade miocárdica com 18F-fluoro-desoxi-glicose utilizando dieta restrita em carboidratos: estudo comparativo com o clamp hiperinsulínico euglicêmico." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-16122008-104419/.

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INTRODUÇÃO: Em pacientes com infarto do miocárdio (IM) e disfunção cardíaca, a evidência de viabilidade miocárdica é primordial, e o exame tomográfico por emissão de pósitrons com 18F-fluoro-desoxi-glicose (18FDG-PET) é o padrão-ouro para essa identificação. Existe preferência, na literatura, pela realização do clamp hiperínsulínico euglicêmico (CLAMP) antes da injeção de 18FDG para estimular todo o miocárdio a consumir glicose (GLI), garantindo assim a sua captação pelas áreas de miocárdio hibernado (MH). No entanto, essa técnica é trabalhosa, além do risco de hipoglicemia durante a realizaçã

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Liao, Ming-Hui, and 廖敏惠. "Highly active-retroviral therapy related metabolic complications." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/83177925910077861648.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>91<br>Part 1. Highly active-retroviral therapy related metabolic complications Background Treatment of human immunodeficiency virus (HIV) infection has evolved dramatically during the past 5 years. Standard care with potent multidrug regimens has resulted in reduced morbidity and mortality among persons with HIV infection. Such advances, however, have been tempered by a body of reports of adverse events associated with highly active antiretroviral therapy (HAART). Of particular concern is the emergence of morphologic and metabolic abnormalities, often referred

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