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Journal articles on the topic 'Methyl compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Osarumwense, P. O., M. O. Edema, and C. O. Usifoh. "Synthesis And Anagesic activities of Quinazolin-4(3H)-One, 2-Methyl-4(3H)-Quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 87–91. http://dx.doi.org/10.22270/jddt.v10i4-s.4209.

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Background: Objective: The current study is aimed at the synthesis of these quinazolinone derivatives quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one and evaluate them for their analgesic activity. Method: The condensation of 2-amino-methyl-4-methoxybenzoate with acetic anhydride yielded the cyclic compound 2-methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which further produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate The quinazolinone derivatives quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Ph

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Malo, Edi A., Verónica Gutiérrez-Escobar, Federico Castrejón-Ayala, and Julio C. Rojas. "The Aggregation Pheromone of Metamasius spinolae (Coleoptera: Dryophthoridae) Revisited: Less is More." Environmental Entomology 49, no. 4 (2020): 803–9. http://dx.doi.org/10.1093/ee/nvaa054.

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Abstract The weevil Metamasius spinolae (Gyllenhal) is the most important insect pest of cultivated prickly pear in Mexico. A previous work reported that the pheromone of this weevil species was composed by three components. In this study, we reinvestigated the aggregation pheromone of M. spinolae using gas chromatography-electroantennography and gas chromatography–mass spectrometry to locate and identify new potential pheromonal compounds. The behavioral activity of identified compounds was evaluated in laboratory and field trials. Metamasius spinolae males released four compounds: 2-methyl-4

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AL-ALAAF, Hiba Ameen, and Mohammed A. AL-IRAQI. "Synthesis of Some New Hydrazones from Quinazolinone Moiety." Eurasia Proceedings of Science Technology Engineering and Mathematics 16 (December 31, 2021): 52–56. http://dx.doi.org/10.55549/epstem.1068546.

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Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (4) is one of the important heterocyclic compounds. It isused as a precursor to synthesis new derivatives of quinazolin-4-one moiety. The compound (4) was synthesized via a series of steps from anthranilic acid. The anthranilic acid was converted to its methyl ester (1) by esterification with methanol under acidic condition. The ester (1) was reacted with chloroacetyl chloride to produce methyl α-chloroacetamido benzoate (2). The chloro compound (2) was converted to the corresponding thiocyanato compound (3) by its reaction with ammonium thiocyanate

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Muharni, Muharni, Fitrya Fitrya, Milanti Okta Ruliza, Dwi Anjar Susanti, and Elfita Elfita. "Di-(2-ethylhexyl)phthalate and Pyranon Derivated from Endophytic fungi Penicillium sp the Leave of Kunyit Putih (Curcuma zedoaria)." Indonesian Journal of Chemistry 14, no. 3 (2014): 290–96. http://dx.doi.org/10.22146/ijc.21241.

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Two compounds from cultivation of the endophytic fungi Penicillium sp of leaves of kunyit putih (Curcuma zedoaria have been isolated. The endophytic fungus was cultivated on 5 L of Potatos Dextrose Broth (PDB) medium at room temperature (no shaking) for 3 weeks. The cultures were extracted with ethyl acetate to afford 3.0 g of residue after removal of the solvent under reduced pressure. The extract was separated and purified by silica gel column chromatography (CC) and afforded two pure compounds as colorless oily liquid (compound 1) and yellow crystal (compound 2). The structure of these comp

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Peter Osarodion Osarumwense, Mary Olire Edema, and Cyril Odianosen Usifoh. "Synthesis and antibacterial activities of quinazolin-4(3h)-one, 2-methyl-4(3h)-quinazolinone and 2–phenyl-4(3h)-quinazolinone." International Journal of Biological and Pharmaceutical Sciences Archive 1, no. 2 (2021): 077–84. http://dx.doi.org/10.30574/ijbpsa.2021.1.2.0027.

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Background: Quinazoline and quinazolinone scaffolds represent an important class of biologically active nitrogen heterocyclic compounds. Many marketed drugs are based on these moieties. A diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit broad spectrum of biological activities Objective: This study is aimed at the synthesis of these quinazolinone derivatives, quinazolin-4(3H)-One, 2-Methyl-4(3H)-quinazolinone and 2–Phenyl-4(3H)-quinazolin-4(3H)–one and evaluate them for their antibacterial activities. Method: The consolidation of 2-amino-methyl-4-

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Astakala, Rishi Vachaspathy, Gagan Preet, Rainer Ebel, and Marcel Jaspars. "Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate." Molbank 2023, no. 3 (2023): M1697. http://dx.doi.org/10.3390/m1697.

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Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains asso

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Raja, R., M. Suresh, R. Raghunathan, and A. SubbiahPandi. "Crystal structures of methyl 3-(4-isopropylphenyl)-1-methyl-1,2,3,3a,4,9b-hexahydrothiochromeno[4,3-b]pyrrole-3a-carboxylate, methyl 1-methyl-3-(o-tolyl)-1,2,3,3a,4,9b-hexahydrothiochromeno[4,3-b]pyrrole-3a-carboxylate and methyl 1-methyl-3-(o-tolyl)-3,3a,4,9b-tetrahydro-1H-thiochromeno[4,3-c]isoxazole-3a-carboxylate." Acta Crystallographica Section E Crystallographic Communications 71, no. 6 (2015): 574–77. http://dx.doi.org/10.1107/s2056989015008063.

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In the title compounds, C23H27NO2S, (I), and C21H23NO2S, (II), the pyrrole rings have envelope conformations with the C atom substituted by the benzene ring as the flap. In the third title compound, C20H21NO3S, (III), the isoxazole ring has a twisted conformation on the C—C bond substituted by the benzene ring and the carboxylate group. In all three compounds, the thiopyran ring has a half-chair conformation. The mean plane of the pyrrole ring is inclined to the mean plane of the thiopyran ring by 57.07 (9), 58.98 (9) and 60.34 (12)° in (I), (II) and (III), respectively. The benzene rings are

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Jarallah, Aziz Latif, Khalid Fahad Ali, Raied Mustafa Shakir, and Shaimaa Abed Saoud. "Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol)." Ibn AL- Haitham Journal For Pure and Applied Science 32, no. 1 (2019): 56. http://dx.doi.org/10.30526/32.1.1966.

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The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the OH group to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds ( 2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a,b, 4a,b and 5a,b respectively. In the another step the click reacti

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Klinchan, Chayada, Rattiya Namngam, Anek Sitsongkham, and Pitak Chuawong. "Synthesis and Study of Naphthoquinones Derivatives." Applied Mechanics and Materials 855 (October 2016): 26–30. http://dx.doi.org/10.4028/www.scientific.net/amm.855.26.

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In this research, we reported the study and synthesis of naphthoquinones intermediate compounds lead to the target naphthoquinones derivatives product. Naphthoquinones derivatives have long been known to display anticancer and antimalarial activity in addition to a wide variety of other bioactivities. Moreover, it has been reported to possess antimalarial disease against Plasmodium falciparum. The naphthoquinones derivatives product (5) were synthesized by coupling with 2-(3-bromo-2,2-dimethylpropyl)-1-methoxynaphthalene (4) and methyl ketone fatty acid (3). The 2-(3-bromo-2,2-dimethylpropyl)-

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Astiti, Ni Putu Adriani, and Yan Ramona. "GC-MS Analysis of Active and Applicable Compounds in Methanol Extract of Sweet Star Fruit (Averrhoa carambola L.) Leaves." HAYATI Journal of Biosciences 28, no. 1 (2021): 12. http://dx.doi.org/10.4308/hjb.28.1.12.

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The leaves of star fruit plants (Averrhoa carambola) have been traditionally used to cure many diseases, such as hypertension and fever. Besides, the leaves of this plant have also widely been used as the main raw material in lawar (a Balinese traditional food) making. In this research, the methanol extract of this plant leaves was analyzed and identified for active compound contents. The main objective of this research was to investigate types of possible active and applicable compounds contained in such leaves, previously extracted/macerated in methanol solution. Analysis was conducted by ap

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F. H. Ferdosi, Malik, Iqra Haider Khan, Arshad Javaid, Hafiz M. Saeed, Ifrayeem Butt, and Ayesha Munir. "GC-MS ANALYSIS PROFILE AND BIOACTIVE COMPONENTS OF FLOWERS OF Bergenia ciliata, A WEED OF ROCK CREVICES." JOURNAL OF WEED SCIENCE RESEARCH 27, no. 4 (2021): 527–35. http://dx.doi.org/10.28941/pjwsr.v27i4.1012.

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Bergenia ciliata is a weed of hilly areas of Pakistan that generally grows in rock crevices. In the present study, flowers of this weeds were collected from Murree. The dried flowers were extracted in methanol and subjected to GC-MS analysis that showed 7 compounds in it. The predominant compound was hexanedioic acid, bis(2-ethylhexyl) ester (48.88%) followed by γ-sitosterol (22.56%). Moderately occurring compound was cyclohexane, 1,3,5-triphenyl- (12.87%). The remaining compounds namely n-hexadecanoic acid (4.97%), pentadecanoic acid, 14-methyl-, methyl ester (3.77%), 9,12-octadecadienoic aci

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Aggarwal, Navidha, and Sandeep Jain. "A Synthetic Approach, Characterization and Biological Evaluation of Novel 5-(Arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one Derivatives." Asian Journal of Chemistry 33, no. 7 (2021): 1530–36. http://dx.doi.org/10.14233/ajchem.2021.23203.

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The extensive biological potential of thiazolidin-4-one and 1,3,4-thiadiazole moieties, the novel string of 5-(arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one has been synthesized and characterized. The synthesized derivatives were screened for antimicrobial potential using serial tube dilution method. The results showed that all the synthesized compounds have significant biological activity against the microorganisms being tested. The antimicrobial activity of the compounds TA2, TA3, TA4, TA9, TA10 and TA20 against the tested microbial strains was promising. Compound TA4 (

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Ibrahem, Raghad Abdalrazaq, and Shetha F. N. Al Zobady. "SYNTHESIS AND CHARACTERIZATION OF NEW HETEROCYCLIC DERIVATIVES FROM 7- HYDROXY -4- METHYL COUMARIN AND STUDY ANTIOXIDANT ACTIVITY FOR SOME SYNTHETIC COMPOUNDS." Iraqi Journal of Market Research and Consumer Protection 15, no. 1 (2023): 120–31. http://dx.doi.org/10.28936/jmracpc15.1.2023.(11).

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ABSTRACT 7-Hydroxy-4-methyl coumarin(H1) compound have been synthesized by resorcinol and ethyl acetoacetate reaction. 4-methyl-2-oxo-2H-chromen-7-yl 2-chloroacetate(H2) is highly reactive compounds. It has been used as intermediate in some reactions. It has been synthesized and reacted with hydrazine hydrate to produce4-methyl-2-oxo-2H-chromen-7-yl 2-hydrazinylacetate (H3).Schiff Bases Compound (H4) is synthesized by reacting the compound (H3) with P-hydroxy benzaldehyde, then reacted(H4) with sodium azide, mercaptoacetic acid, chloroacetyl chloride and anhydrides such as (3- nitro phathalic

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Fathy, Hoda M., Mohamed I. Aboushoer, Fathallah M. Harraz, Abdallah A. Omar, Gilles Goetz, and Rafael Tabacchi. "Dolabellane Diterpenes from Cleome Droserifolia." Natural Product Communications 3, no. 9 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300915.

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Three diterpenoid dolabellane esters were isolated from Cleome droserifolia. The chemical structures of the isolated compounds were determined by spectral as well as chemical methods. These dolabellanes (I, II and III) are ester derivatives of 3-hydroxy-3-methyl glutaric acid (3-HMGA). Compounds I and II have the second (3HMGA) carboxyl function free, while compound III is the methyl ester of compound I. This is the first report of the isolation of this class of compounds from the genus Cleome and is the first report of the isolation of compound III from a natural source. In addition, eight fl

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Aghakhaninejad, Sarah, Rahmatollah Rahimi, and Solmaz Zargari. "Application of BiVO4 Nanocomposite for Photodegradation of Methyl Orange." Proceedings 9, no. 1 (2018): 52. http://dx.doi.org/10.3390/ecsoc-22-05666.

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In this work, BiVO4–graphene photocatalyst was prepared by a facile one-step hydrothermal method and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The photocatalytic activity of this compound was investigated by destruction of methyl orange (MO) under visible light irradiation. The photodegradation results show that the prepared BVG compound has higher photocatalytic activity than the pure BiVO4 compound. This compound can degrade 98% of MO under visible light irradiation. This work indicates that BiVO4 compoun

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Sanuddin, Mukhlis, Indri Meirista, and Ranny Adia Kinanti. "ACUTE TOXICITY TEST LD50 COMPLEX Fe(II)N-BENZYLMETHYL DITHIOCARBAMATE IN WHITE MICE (Mus muscle)." International Journal of Pharmaceutical Sciences and Medicine 8, no. 5 (2023): 34–40. http://dx.doi.org/10.47760/ijpsm.2023.v08i05.005.

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A toxicity test is a test carried out to estimate the degree of damage caused by a compound to biological or non-biological materials. One of the compounds known to have anticancer, antibacterial, and antifungal effects is Fe(II) N-benzyl methyl dithiocarbamate. This compound has cytotoxic activity on liver cells. The purpose of this study was to determine the LD50 value of Fe (II) N-benzyl methyl Dithiocarbamate and to determine the acute toxicity category of Fe (II) N-benzyl methyl Dithiocarbamate. From the results of research that have been carried out the synthesis of compounds capable of

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Napiórkowska, Mariola, Emilia Grosicka-Maciąg, Piotr Podsadni, and Dagmara Otto-Ślusarczyk. "Anticancer Potential of Halogen Derivatives of Methyl 6-Acetyl-5-Hydroxy-2-Methyl-1-Benzofuran-3-Carboxylate." International Journal of Molecular Sciences 26, no. 12 (2025): 5493. https://doi.org/10.3390/ijms26125493.

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The presented results are a continuation of our research on the synthesis and biological properties of halogen benzofuran derivatives, particularly their anticancer potential. We examined the cytotoxicity of two derivatives, methyl 4-chloro-6-(dichloroacetyl)-5-hydroxy-2-methyl-1-benzofuran-3-carboxylate (7) and methyl 6-(dibromoacetyl)-5-methoxy-2-methyl-1-benzofuran-3-carboxylate (8), in the following human cancer cell lines: SW480, SW620, HCT116, HepG2, PC3, A549, and MDA. The MTT assay results showed that compound 7 exhibited the most promising activity against A549 cells, while compound 8

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Shishkina, Svitlana, Igor Ukrainets, Ganna Hamza та Lina Grinevich. "Molecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate". Acta Crystallographica Section E Crystallographic Communications 74, № 9 (2018): 1299–301. http://dx.doi.org/10.1107/s2056989018011362.

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The title compound, C11H11NO4S, possesses weak analgesic properties and is a source compound for the synthesis of highly active analgesic and anti-inflammatory compounds. The benzothiazine ring adopts a conformation intermediate between twist-boat and sofa. The ester substituent is turned towards the endocyclic double bond because of steric repulsion. In the crystal, the molecules form columns along the [001] direction, bound by N—H...O hydrogen bonds and stacking interactions.

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Juswardi, Rina Yuliana, Nina Tanzerina, Harmida, Hanifa Marisa, and Mustafa Kamal. "Metabolite profiling of butterfly pea flower (Clitoria ternatea L.) in the flowering development phase." Open Access Research Journal of Biology and Pharmacy 11, no. 1 (2024): 049–57. http://dx.doi.org/10.53022/oarjbp.2024.11.1.0022.

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The butter pea flower (Clitoria ternatea L.) has long been known as a medicinal plant because it contains various metabolite compounds, the content of metabolite compounds that are influenced by plant development. So it is necessary to conduct metabolomics profiling research to determine the metabolite compounds found in butterfly pea flowers in the flower bud, blooming, and wilting phases. Metabolite profiling from ethanol extract in the development phase of butterfly pea flowers in the bud, blooming, and wilting phases using GC-MS analysis identified 20 metabolite compounds each with butterf

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Osarumwense, Peter Osarodion. "Synthesis and antibacterial activity of newly synthesized 7-chloro–2–methyl-4h–benzo[d] [1, 3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3h)–one." GSC Biological and Pharmaceutical Sciences 11, no. 1 (2020): 212–20. https://doi.org/10.5281/zenodo.4277223.

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The current study is aimed at the synthesis of these quinazolinone derivatives 7-Chloro-2-Methyl-4H-benzo[d]-[1,3]-Oxazin-4-one and 3-Amino-7-Chloro-2—Methyl-3H-Quinazolin-4-One and evaluate them for their antibacterial activity.The condensation of 2-amino-methyl-4-methoxybenzoate with acetic anhydride yielded the cyclic compound 2-methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which further produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-me

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Al-Ibrahemi, Nibras, Ayat Shanshol Al-Yasssiry, Zainab Naser Al-Laith, and Balqees Hadi Al-Musawi. "Phytochemical Study of Volatile Oils for the Ocimum basilicum L. and Mentha spicata By Gas Chromatography Technique." IOP Conference Series: Earth and Environmental Science 1158, no. 6 (2023): 062004. http://dx.doi.org/10.1088/1755-1315/1158/6/062004.

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Abstract This study emphasized on the identification and detection the secondary metabolism compounds different of volatile oils by Gas Chromatography Technique of Ocimum basilicum L. and Mentha spicata L plant from Labiate (Lamiaceae) family cultivated in Iraq by suxhlet apparatus. the medicinal importment acquired this study and to know the active compound in the volatile oil was identified in plant extract of aerial parts by Gas Chromatography Mass, The result showed that of (80g) of O.basilicum and M. spicata has produced volatile oil ( 2.5% and 3. 75%) respectively, The study has shown th

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Ahmadu, AA, A. Agunu, and EM Abdurrahman. "Anti-Inflammatory Constituents of Alchornea cordifolia Leaves." Nigerian Journal of Natural Products and Medicine 19 (August 28, 2015): 60–64. http://dx.doi.org/10.4314/njnpm.v19i0.5.

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Alchornea cordifolia (Schum and Thonn) Muell. Arg. (Euphorbiaceae) is a traditional medicinal plant widely distributed in West Africa including Nigeria.The plant has been used for ethnomedicinal purposes against wounds, ulcers, and sores. The decoction of the leaves has been reported to provide remedies for bronchial problems, rheumatic pain and cough. From the dichloromethane and ethyl acetate soluble parts of the Methanol leaf extract, two compounds namely Lup-20(29)-en-3c-ol (lupenol) and Methyl 3, 4,5-trihydroxy benzoate (Methyl gallate) were isolated and their structures elucidated. Anti-

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Bús, Csaba, Norbert Kúsz, Gusztáv Jakab, et al. "Phenanthrenes from Juncus Compressus Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities." Molecules 23, no. 8 (2018): 2085. http://dx.doi.org/10.3390/molecules23082085.

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Juncaceae species are rich sources of phenanthrenes. The present study has focused on the isolation and structure determination of biologically active components from Juncus compressus. Eleven compounds (nine phenanthrenes and two flavonoids) have been isolated from the plant by the combination of different chromatographic methods. Two compounds (compressins A (Compound 1) and B (Compound 2)) are novel natural products, while seven phenanthrenes (effusol (Compound 3), effususol (Compound 4), juncusol (Compound 5), 2-hydroxy-1-methyl-4-oxymethylene-5-vinyl-9,10-dihydrophenanthrene (Compound 6),

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M., B. Deshmukh, S. Patil S., and R. Mulik A. "Synthesis of some new tricyclic 1,4-benzothiazinones." Journal of Indian Chemical Society Vol. 79, May 2002 (2002): 472–74. https://doi.org/10.5281/zenodo.5843264.

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Department of Chemistry, Shivaji University, Kolhapur-416 004, India <em>E-mail </em>: Mdeshmukh 1 @ rediffmail.com <em>Manuscript received 31 January 2001, revised 17 August 2001, accepted 16 October 2001</em> 2-Aminothiophenol on reaction with dimethyl oxalate and methyl 2-chloropropionate gives 1,4-benzothiazinone (la, lb) which when reacted with ethyl chloroacetate give <em>N</em>-ethoxycarbonylmethyl-1,4-benzothiazine-2,3-dione (2a<sub>1</sub>). Compound 2 on reaction with hydrazine hydrate affords N-hydrazidomethy1-1,4-benzothiazine-2,3-dione (3). Compound 3 is cyclized in pres

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Prasetiyo, Himawan, Sri Purwaningsih, Iriani Setyaningsih, Mala Nurilmala, Uju Uju, and Kustiyariah Tarman. "Off-odour Identification from Volatile Organic Compounds (VOCs) of Spirulina." BIO Web of Conferences 92 (2024): 02006. http://dx.doi.org/10.1051/bioconf/20249202006.

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Spirulina platensis is a common cyanobacteria microalga with high nutrition and bioactive compound sources. The addition of spirulina in foods and beverages improves nutrition and bioactive compound content. However, certain species of cyanobacteria are known to produce various compounds causing off-odour. This study investigates the chemical profile and volatile organic compounds (VOCs) in spirulina biomass and determine off-odour potency. The spirulina extract was analysed phytochemical qualitatively and GC-MS (Gas Chromatography-Mass Spectrometry). The Spectra mass was compared to the mass

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Hafez, Hend N., and Abdel-Rhman B. A. El-Gazzar. "Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives." Acta Pharmaceutica 67, no. 4 (2017): 527–42. http://dx.doi.org/10.1515/acph-2017-0039.

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Abstract 3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3

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Mohammed, Mohammed Hassan, Monther Faisal Mahdi, and Fadhil Mohsin Hamed. "Synthesis of 2, 3-Dihydro-1,4-naphthaquinone Derivatives for Targeting the Altered Cancer Cells Metabolism." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 7 (2013): 472–81. http://dx.doi.org/10.24297/jac.v12i7.2804.

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A new four derivatives of 2,3-Dihydro-1,4-naphthaquinonewere synthesizedas possible bioreductiveprodrugs for5-fluorouracil (5-Fu),Mercaptopurine (6-MP), N-acetyl cysteine (NAC)and 3-bromopyrovic acid (3-BPA) to selectively deliver the drugs into the cancer cells and these are:2-((5-fluoro-1,2-dihydropyrimidin-4-yloxy)methyl)-3-hydroxy naphthalene-1,4dione(compound A),2-((9H-purin-6-ylthio)-3-hydroxyl naphthalene-1,4dione(compound B)acetmido-3-((3-methyl-1,4-dihydronaphthalen-2-yl)methylthio)propanoicacid (compound C)and hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl3-bromo-2-oxopropanoate

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Mohammed, Mohammed Hassan, Monther Faisal Mahdi, and Fadhil Mohsin Hamed. "Synthesis of 2, 3-Dihydro-1,4-naphthaquinone Derivatives for Targeting the Altered Cancer Cells Metabolism." JOURNAL OF ADVANCES IN CHEMISTRY 4, no. 2 (2008): 472–81. http://dx.doi.org/10.24297/jac.v4i2.2708.

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A new four derivatives of 2,3-Dihydro-1,4-naphthaquinonewere synthesizedas possible bioreductiveprodrugs for5-fluorouracil (5-Fu),Mercaptopurine (6-MP), N-acetyl cysteine (NAC)and 3-bromopyrovic acid (3-BPA) to selectively deliver the drugs into the cancer cells and these are:2-((5-fluoro-1,2-dihydropyrimidin-4-yloxy)methyl)-3-hydroxy naphthalene-1,4dione(compound A),2-((9H-purin-6-ylthio)-3-hydroxyl naphthalene-1,4dione(compound B)acetmido-3-((3-methyl-1,4-dihydronaphthalen-2-yl)methylthio)propanoicacid (compound C)and hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl3-bromo-2-oxopropanoate

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29

Hu, Yuan-bin, Jun-ying Sun, Tang-yun Yu, et al. "Proliferative Constituents from the Leaves of Micromelum integerrimum." Natural Product Communications 10, no. 10 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001020.

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wo new compounds, 5- O-methyl-4-desmethyl-myricanol (1) and 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (2), were isolated from the leaves of Micromelum integerrimum. Their structures were determined by spectroscopic methods. Additionally, compound 1 could stimulate the growth of NIH3T3 cells and promote cell migration. Compound 1 might exert its effects through increasing the protein expression of connective tissue growth factor.

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Laxminarayana, E., P. Bhasker, D. Ramesh, Md Rafeeq, and B. Srinivasa Reddy. "Green Synthesis, Molecular Docking Studies and Anticancer Effects of 3-Methyl-2-(((1-Methyl-1H-Benzo[d]imidazol-2-yl) thio) Methyl) Quinazolin-4(3H)-One." Research Journal of Chemistry and Environment 25, no. 7 (2021): 138–46. http://dx.doi.org/10.25303/257rjce13821.

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compound 2-((1H-benzo[d]imidazol-2-yl)thio)acetic acid (1) with o-aminobenzamide (2) gave compound (2-[1-(1H-benzimidazol-2-yl)-ethylsulfanyl]-3H-quinazolin-4-one (3). 3 could also be syntehsized by an alternative two routes scheme 2 and scheme 3. It appears from scheme 3 that it is giving good yields under green and eco-friendly conditions using PEG-600 (polyethylent glycol). Compound 10 was synthesized in two routes scheme4 and scheme 5. It appears from Route B (Scheme 4) that it is giving good yields: alkylation followed by oxidation in route A followed by alkylation in PEG-600 used as a gr

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31

Khan, Ayad Kareem. "Facile Synthesis, Characterization of New Quinazolinones with Different Azo Compounds, 1,2,3-Triazole Moieties and Evaluation Their Anti-bacterial Activity." Al-Mustansiriyah Journal of Science 28, no. 3 (2018): 122. http://dx.doi.org/10.23851/mjs.v28i3.180.

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In the present research, a series of some azo compounds (5-9) and 1,2,3-triazoles derived from 2-methyl quinazolin-4(3H)-one were synthesized successfully by stepwise routes includes the following: 3-amino-2-methylquinazolin-4(3H)-one (3) prepared firstly by conversion of 2-aminobenzoic acid into methyl 2-aminobenzoate (1) followed by reaction with acetic anhydride to form methyl -2-acetamidobenzoate (2). The amide then allowed reacting with hydrazine hydrate to give compound (3). Diazotization reaction with sodium nitrite in the presence of hydrochloric acid yield the 3-(chlorodiazenyl)-2-met

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32

Végh, Daniel, Michal Uher, Oľga Rajniaková, Miloslava Dandárová, and Milan Kováč. "Preparation of vic-Mercaptoisopentanols." Collection of Czechoslovak Chemical Communications 58, no. 2 (1993): 404–8. http://dx.doi.org/10.1135/cccc19930404.

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This paper describes the preparation of some mercaptoisopentanols: 2-mercapto-3-methyl-1-butanol (I), 1-mercapto-3-methyl-2-butanol (II), 3-mercapto-3-methyl-2-butanol (III) and the unsaturated analogue of compound I - 2-mercapto-3-methyl-2-buten-1-ol (IV). These compounds belong to the flavonoid group present in food responsible for deterioration of their gustatory properties.

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33

Saragih, Magdalena, Trizelia Trizelia, Nurbailis Nurbailis, and Yusniwati Yusniwati. "Profil GCMS Senyawa Kimia Ekstrak Metanol Isolat Cendawan Entomopatogen Beauveria Bassiana Dan Akar Cabai Sebagai Pemacu Pertumbuhan Cabai." Agrotekma: Jurnal Agroteknologi dan Ilmu Pertanian 4, no. 2 (2020): 106–18. http://dx.doi.org/10.31289/agr.v4i2.3840.

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The aim of this study was to identify the chemical compound methanol extract of entomopathogenic fungus Beauveria bassiana from insect walang sangit and the chemical compound roots of red chili plants that were able to stimulate the growth of chilli plants after being applied with entomopathogenic fungus B. bassiana through seed immersion inoculation using GCMS method. The chemical compound identified as a growth booster in B. bassiana fungus isolates from the insect walang sangit is an Acetic acid Ethanoic acid Ethylic acid Glacial acetic acid CH3COOH, Hexadecanoic acid, methyl ester (CAS) Me

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34

Nasr, Fahd A., Nasir Ali Siddiqui, Ali A. ElGamal, et al. "Cytotoxic activity of guaiane-type sesquiterpene lactone (deoxycynaropicrin) isolated from the leaves of Centaurothamnus maximus." Open Chemistry 20, no. 1 (2022): 410–16. http://dx.doi.org/10.1515/chem-2022-0163.

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Abstract Guaianolide is a type of naturally occurring sesquiterpene lactone compounds that have attracted attention due to their diverse biological properties. In this work, a guaiane-type sesquiterpene lactone identified as deoxycynaropicrin (compound 1) was isolated and reported for the first time from the leaves of Centaurothamnus maximus with two known flavonoid derivatives namely luteolin 6-O-methyl ether (compound 2) and quercetin 3-methyl ether 5-O-glucopyranoside (compound 3). The cytotoxic activity of all the three compounds was evaluated against the THP-1 human leukemia cell lines. M

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35

Do, Thanh-Hung, Thuc-Huy Duong, Huy Truong Nguyen, et al. "Biological Activities of Lichen-Derived Monoaromatic Compounds." Molecules 27, no. 9 (2022): 2871. http://dx.doi.org/10.3390/molecules27092871.

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Lichen-derived monoaromatic compounds are bioactive compounds, associated with various pharmacological properties: antioxidant, antifungal, antiviral, cytotoxicity, and enzyme inhibition. However, little is known about data regarding alpha-glucosidase inhibition and antimicrobial activity. Very few compounds were reported to have these activities. In this paper, a series of monoaromatic compounds from a lichen source were isolated and structurally elucidated. They are 3,5-dihydroxybenzoic acid (1), 3,5-dihydroxybenzoate methyl (2), 3,5-dihydroxy-4-methylbenzoic acid (3), 3,5-dihydroxy-4-methox

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36

Jin, Bo, Jia-yi Chen, Zun-lai Sheng, Meng-qing Sun, and Hong-liang Yang. "Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives." Molecules 27, no. 3 (2022): 1103. http://dx.doi.org/10.3390/molecules27031103.

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In this study, a series of 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives was synthesized and characterized by 1H NMR, 13C NMR, and LC-MS. The conducted screening antibacterial studies of the new 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives established that the methyl sulfonic acid esters have broad activity spectrum towards Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis and Staphylococcus epidermidis. Among them, compound 12e has the most potent activity, with an MIC of 16 μg/mL against B.subtilis, and could reduce the instantaneous growth rate of bacteria. F

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37

Sen, Rupam, Abhishek Banerjee, Paula Brandão, and Zhi Lin. "Observation of Structural Diversity Based on the Cationic Influence in a Series of Zn/Cd Pyridine Carboxylate Coordination Compounds." Crystals 13, no. 2 (2023): 186. http://dx.doi.org/10.3390/cryst13020186.

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In this study, we used a 6-methyl-2,3-pyridine dicarboxylate ligand to develop the frameworks. Two novel compounds, [Zn2(L)2(H2O)4] (1) and [Cd(L)(H2O)] (2) (where L = 6-methyl-pyridine-2,3-dicarboxylate) were produced. The compounds were characterized by elemental analysis, powder X-ray diffraction, Fourier-transform infrared spectroscopy and single crystal X-ray crystallography. We successfully tuned the framework dimensionality by varying the size of the metal ions from small Zn to large Cd ions. Single crystal X-ray investigations of compound 1 show a good dimeric motif, while compound 2 s

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38

Rahayu, D. U. C., R. S. Al-Laily, D. A. Khalwani, et al. "MICROWAVE-ASSISTED SYNTHESIS OF 4-METHYL COUMARINS, THEIR ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES." RASAYAN Journal of Chemistry 15, no. 02 (2022): 1053–62. http://dx.doi.org/10.31788/rjc.2022.1526780.

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Coumarins are heterocyclic compounds naturally found in plants. Coumarin-derived compounds have been commonly synthesized and some have exhibited a wide range of bioactivities. In searching for coumarins-based antioxidants and antibacterial, in this study, various 4-methyl coumarins have been synthesized by reacting ethyl acetoacetate with several phenol compounds, e.g. resorcinol, catechol, hydroquinone, α-naphthol, and β-naphthol, catalyzed by multiple Lewis acids, e.g. SnCl2, SnCl2.2H2O, ZnCl2, and AlCl3, using microwave irradiation via the Pechmann condensation. The antioxidant activities

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39

S Dharmaraj Santhosam, P Selvam, and Abhinandan Danodia. "Isolation and characterization of three isolates of Abrus precatorius seeds by LC-MS, 1HNMR, And 13CNMR." International Journal of Science and Research Archive 8, no. 1 (2023): 404–20. http://dx.doi.org/10.30574/ijsra.2023.8.1.0056.

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The three isolates were isolated from the methanolic extract of Abrus precatorius seeds by column chromatography using silica gel 60-120 mesh as the adsorbent and methanol as the mobile phase. The isolated compounds are further purified by TLC. The compounds that have the same RF value are combined. The crude extract was named CMME. The isolated compounds named CMME I, CMME II, and CMME III are first-eluted, second, eluted, and third-eluted compounds respectively. The isolated compounds were characterized by LC-MS, 1H NMR, and 13C NMR. The compound I was found to be (4,6-O-Benzylidene) methyl-

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40

Boyé, O., A. Brossi, H. J. C. Yeh, E. Hamel, B. Wegrzynski, and V. Toome. "Natural products. Antitubulin effect of congeners of N-acetylcolchinyl methyl ether: synthesis of optically active 5-acetamidodeaminocolchinyl methyl ether and of demethoxy analogues of deaminocolchinyl methyl ether." Canadian Journal of Chemistry 70, no. 5 (1992): 1237–49. http://dx.doi.org/10.1139/v92-160.

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Trimethoxy-substituted dihydrodibenzocycloheptenes 4–7, required for a structure–activity study measuring the inhibition of tubulin polymerization in vitro, were synthesized by four different routes: (1) Synthesis of 4 was achieved from 2,3-dimethoxybenzaldehyde via biphenyl aldehyde 17, chain lengthening to propionic acid 20, acid-catalyzed cyclization toward ketone 21, and removal of the carbonyl group. (2) Compound 5 was obtained by eliminating the sterically most hindered methoxy group in 25 or 26 by metal reduction in alcohol. (3) Compound 6 was prepared from biphenyl aldehyde 34 obtained

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41

Chaudhary, Sakshi. "SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NEWER BENZOTHIAZINYL / BENZOXAZINYL INDOLES." Indian Drugs 60, no. 04 (2023): 17–23. http://dx.doi.org/10.53879/id.60.04.13415.

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3-Acetyl-2-methyl-indole (1) was synthesized by acetylation of 2-methyl indole with acetyl chloride. Facile condensation of compound (1) with various aromatic aldehydes yielded 1-(2’ -methylindolyl) arylidenyl chalcones (2-7), which on treating with 2-aminothiophenol and 2-aminophenol afforded 2-substitutedphenyl-2,3-dihydro-4-(2’ -methylindolyl)-1,5-benzthiazepines (8-13) and 2-substitutedphenyl-2,3-dihydro-4-(2’ -methylindolyl)-1,5-benzoxazepines (14-19), respectively. The structures of all the compounds were delineated by elemental analysis, IR and proton magnetic resonance. The newly synth

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42

Black, DS, N. Chaichit, BM Gatehouse, and GI Moss. "Unusual Formation of New Indole-Containing Heterocyclic Ring Systems." Australian Journal of Chemistry 40, no. 12 (1987): 1965. http://dx.doi.org/10.1071/ch9871965.

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The oxazinoindoletrione (3) underwent reaction with aqueous ammonia in methanol or ethanol to yield the polycyclic methyl or ethyl esters (4) and (5) respectively. Reaction of trione (3) with gaseous ammonia in dry ethanol gave the aminobenzodiazepinone (7). This compound lost ammonia on heating in toluene to give compound (11) and in the presence of methanol or ethanol gave the methyl or ethyl esters (9) and (10) respectively. The structures of compounds (4), (7) and (10) were all established by X-ray crystallography.

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43

Emmie de, Abreu, S. K. Chandavarkar, B. S. Biradar, Bobde S. S., S. P. Naik, and S. N. Mamledesai. "DESIGN, SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF QUINOLIN-2-ONE DERIVATIVES." INDIAN DRUGS 56, no. 08 (2019): 21–26. http://dx.doi.org/10.53879/id.56.08.11925.

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Starting material 4-hydroxy-1-phenyl/methyl-quinolin-2-(1H)-one was treated with phosphorous oxychloride and then subjected to Mannich reaction to yield title 4-chloro-1-phenyl/methyl-3-[3- (substituted) propanoyl] quinolin-2(1H)-one derivatives compounds IIa (1-7)/ IIb (1-7). Molecular docking studies of the compounds were carried out using Molegro Virtual Docker. All the synthesized compounds were characterized by IR, 1H-NMR and Mass Spectral data and were tested for their antidepressant activity. Amongst the synthesized compounds, compound 4-chloro-1-phenyl-3-[3-(morpholinopropanoyl] quinol

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44

Nori-Shargh, Davood, Neda Hassanzadeh, Meisam Kosari, Parvin Rabieikarahroudi, Hooriye Yahyaei, and Sasan Sharifi. "Stereoelectronic interaction effects on the conformational properties of 5-methyl-5-aza-1,3-dithiacyclohexane and its analogous containing N, P, O, and Se atoms — A hybrid density functional theory (DFT), ab initio study, and natural bond orbital (NBO) analysis." Canadian Journal of Chemistry 88, no. 7 (2010): 579–87. http://dx.doi.org/10.1139/v10-022.

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Natural bond orbital (NBO) analysis, hybrid density functional theory (hybrid DFT: B3LYP/6-311+G**//B3LYP/6-311+G**), and ab initio molecular orbital (MO: MP2/6-311+G**//B3LYP/6-311+G**) based methods were used to study the electronic delocalization energy (DE), dipole–dipole interactions, and steric repulsions on the conformational properties of 5-methyl-5-aza-1,3-dioxacyclohexane (1) (-phospha- (2), -arsena- (3)), 5-methyl-5-aza-1,3-dithiacyclohexane (4) (-phospha- (5), -arsena- (6)), and 5-methyl-5-aza-1,3-diselenacyclohexane (7) (-phospha- (8), -arsena- (9)). The MP2/6-311+G**//B3LYP/6-311

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45

Golubenkova, Alexandra S., Nikita E. Golantsov, and Leonid G. Voskressensky. "Methyl (2E)-3-[3-Benzyl-2-(3-methoxy-3-oxoprop-1-yn-1-yl)-2-(1-naphthyl)imidazolidin-1-yl]acrylate." Molbank 2021, no. 1 (2020): M1176. http://dx.doi.org/10.3390/m1176.

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Compounds with propargylamine moiety are useful synthetic precursors of several important classes of nitrogen-containing heterocycles. The title compound, methyl (2E)-3-[3-benzyl-2-(3-methoxy-3-oxoprop-1-yn-1-yl)-2-(1-naphthyl)imidazolidine-1-yl]acrylate, has been prepared by domino-reaction, employing easily available 1-benzyl-2-(1-naphthyl)-4,5-dihydro-1H-imidazole and methyl propiolate in a high 92% yield. The structure of title compound was determined using 1H-NMR, 13C-NMR, UV, FT-IR and HRMS (High-Resolution Mass Spectrometry).

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46

Padmaja, V., M. Sumakanth, and P. Shashikala. "Synthesis, Characterization and Molecular Docking Studies of Novel Mannich Bases of Indole Analogs as Potent Antibacterial and Anticancer Agents." Asian Journal of Chemistry 35, no. 1 (2022): 217–33. http://dx.doi.org/10.14233/ajchem.2023.24004.

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A series of a novel indole analogs (5-substituted-1-methyl/ethyl-3-((5-methyl-1-(morpholino/ piperazinmethyl)-1H-pyrazol-3-yl)-imino)indolin-2-one (5a-l) were synthesized via Schiff base and Mannich base mechanism. The structures of synthesized compounds were confirmed by IR, 1H NMR and mass spectral data. The antibacterial activity by was measured by agar diffusion method. Some of the analogs (5b, 5c, 5h, 5i and 5j) showed excellent antibacterial recreation against Staphylococcus aureus, Bacillus subtilis and Escherichia coli, Salmonella paratyphi, Pseudomonas and compounds 5f, 5g, 5i showed

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47

Osarumwense, Osarodion Peter. "Synthesis and antibacterial activity of 3-amino-6-iodo-2-methyl quinazolin 4-(3H)-one and 6-iodo-2-methyl-4H-benzo [D] [1, 3] oxazin-4-one." World Journal of Advanced Research and Reviews 2, no. 3 (2019): 014–20. https://doi.org/10.5281/zenodo.4309464.

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Quinazolines and its derivatives represent one of the most active classes of compounds, which possess wide range of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory, anticancer, and anti-hypertensive ,antifungal, anti-HIV, antioxidant, analgesic, anticonvulsant, antimalarial, antitumor, anti-tubercular activities. The objective of the present study was to synthesize these quinazolinone derivatives 6-iodo-2-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-amino-6-iodo-2—methyl-3H-quinazolin-4-one and evaluate them for their antibacterial activity. 6-lodo-

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48

Luo, Xiaowei, Xuefeng Zhou, and Yonghong Liu. "Nitrogenous Compounds Produced by the Deep Sea Derived Fungus Leptosphaeria sp. SCSIO 41005." Natural Product Communications 13, no. 6 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300606.

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Four nitrogenous compounds, including two new compounds methyl-4-((1-hydroxy-3-methylpentan-2-yl)amino)–3-methyl-4-oxobutanoate (1), 4-((1-acetoxy-3-methylpentan-2-yl)amino)–3-methyl-4-oxobutanoic acid (2), and two amino acid derivatives (3, 4), were isolated from the deep sea derived fungus Leptosphaeria sp. SCSIO 41005, together with a cyclohexanone derivative (5) as new natural compound and other three known compounds (6–8). Their structures were elucidated by means of comprehensive 1D, 2D NMR and HR-ESI-MS spectroscopic methods. All the compounds were evaluated for their cytotoxic and anti

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49

Ibrahim, A. A., O. M. Yahya, and M. A. Ibrahim. "Theoretical Prediction of Possible Drug Treatment of COVID-19 using Coumarins Containing Chloroquine Moeity." Asian Journal of Chemistry 32, no. 12 (2020): 3120–26. http://dx.doi.org/10.14233/ajchem.2020.22914.

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Chloroquine was theoretically reacted with the coumarin compound. Two compounds viz. [N-(7-chloroquinolin-4-yl)-N-(5-(diethylamino)-pentan-2-yl)-4-methyl-2-oxo-2H-chromene-7- sulfonamide] (3) and [N-(7-chloroquinolin-4-yl)-N-(5-(diethylamino)pentan-2-yl)-4-methyl-2-oxo- 2H-chromene-6-sulfonamide] (4) were suggested. The results showed that compound 4 may influence the COVID-19 treatment. The physico-chemical parameters were determined through theoretical calculations by using Hartree-Fock at different basis sets (6-31G), (STO/3G) and the semi-empirical (AM1) method. The calculations demonstrat

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50

RAVI KUMAR, Gollapudi, Chandra Rao DASIREDDY, Ravi VARALA, Vijay KOTRA, and Hari Babu BOLLIKOLLA. "An efficient approach for the synthesis of novel methyl sulfones in acetic acid medium and evaluation of antimicrobial activity." TURKISH JOURNAL OF CHEMISTRY 44, no. 5 (2020): 1386–94. http://dx.doi.org/10.3906/kim-2003-10.

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A series of nine methyl sulphones (3a–3i) starting from the aldehydes (1a–1i) were synthesized in two consecutive steps. In the first step, preparation of allyl alcohols (2a–2i) from their corresponding aldehydes by the reaction of sodium borohydride in methanol at room temperature is reported. Finally, methyl sulphones are synthesized by condensing sodium methyl sulfinates with allyl alcohols in the presence of BF3.Et2O in acetic acid medium at room temperature for about 2–3 h. The reaction conditions are simple, yields are high (85%–95%), and the products were obtained with good purity. All

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