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Journal articles on the topic 'Methylthiazole'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Dong, Min, and Liang-Dong Sun. "4-Methylthiazole-5-carbaldehyde." Acta Crystallographica Section E Structure Reports Online 61, no. 8 (2005): o2712—o2713. http://dx.doi.org/10.1107/s1600536805023202.

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2

Nimbalkar, Seijas, Vazquez-Tato, and Nikalje. "Ultrasound-Assisted One Pot Synthesis of Novel 5-(1-(Substituted phenyl)-4,5-diphenyl-1H-imidazol-2-yl)-4-methylthiazole." Proceedings 9, no. 1 (2018): 63. http://dx.doi.org/10.3390/ecsoc-22-05795.

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This work reports synthesis of ten novel derivatives of 5-(1-(substituted phenyl)-4,5-diphenyl-1H-imidazol-2-yl)-4-methylthiazole 5(a–o). The reaction of benzil, primary aryl amines, 4-methylthiazole-5-carbaldehyde and ammonium acetate was carried out in one pot in the presence of eco-friendly catalyst Ceric ammonium nitrate in solvent ethanol to give final compounds. The structures of the synthesized compounds were confirmed by spectral characterization such as IR, 1H-NMR, 13C-NMR and mass spectral studies.

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3

Song, Qing Bao, Zhi Min Jin, Hai Bin Wang, and Biao Jiang. "N′-(Benzenesulfonyl)-4-methylthiazole-5-carbohydrazide." Acta Crystallographica Section E Structure Reports Online 60, no. 8 (2004): o1292—o1293. http://dx.doi.org/10.1107/s1600536804015806.

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4

Abel, M. D., A. D. Cameron, C. M. Ha, et al. "Novel Azolylalkyloxy Compounds with Antipicornaviral Activity." Antiviral Chemistry and Chemotherapy 6, no. 4 (1995): 245–54. http://dx.doi.org/10.1177/095632029500600407.

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A novel series of azolylalkyloxy compounds was designed, synthesized and evaluated for antipicornaviral activity. Several of the compounds exhibited in vitro activity comparable to that of Disoxarll. An investigation of qualitative structure-activity relationships indicated that the optimal length of the alkyI chain is six or seven carbon atoms, with seven being marginally superior. The effect of different azole moieties on activity was relatively small, with 3-methylisoxazole and 4-methylthiazole being most effective. The nature of the oxy substituent was found to be extremely important for a

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5

Antonov, E. A., A. A. Zhirov, A. T. Kirsanov, et al. "Synthesis of 5-(2-chloroethyl)-4-methylthiazole using the reaction of 5-(2-hydroxyethyl)-4-methylthiazole with phosphorus pentachloride." Pharmaceutical Chemistry Journal 33, no. 12 (1999): 658–60. http://dx.doi.org/10.1007/bf02974943.

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6

Hartung, Jens, Kristina Daniel, Ingrid Svoboda, and Hartmut Fuess. "5-(4-Methoxyphenyl)-4-methylthiazole-2(3H)-thione." Acta Crystallographica Section E Structure Reports Online 61, no. 6 (2005): o1744—o1746. http://dx.doi.org/10.1107/s1600536805013863.

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7

Gol'dfarb, Ya L., G. P. Gromova, and L. I. Belen'kii. "Course of bromination of thiazole and 2-methylthiazole." Chemistry of Heterocyclic Compounds 22, no. 6 (1986): 663–66. http://dx.doi.org/10.1007/bf00575251.

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8

Antonov, E. A., A. A. Zhirov, A. T. Kirsanov, et al. "ChemInform Abstract: Synthesis of 5-(2-Chloroethyl)-4-methylthiazole by Reaction of 5-(2-Hydroxyethyl)-4-methylthiazole with Phosphorus Pentachloride." ChemInform 31, no. 16 (2010): no. http://dx.doi.org/10.1002/chin.200016056.

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9

Jäger, W., and H. Mäder. "The Microwave Spectrum of 4-Methylthiazole: Methyl Internal Rotation, 14N Nuclear Quadrupole Coupling and Electric Dipole Moment." Zeitschrift für Naturforschung A 42, no. 12 (1987): 1405–9. http://dx.doi.org/10.1515/zna-1987-1208.

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The microwave spectrum of 4-methylthiazole has been investigated in the frequency region from 8 to 36 GHz, employing both Fourier transform and Stark spectroscopy. The results of 14N quadrupole hyperfine structure, methyl internal rotation and fourth order centrifugal distortion analyses are given. The dipole moment components could be determined from the Stark splittings of some rotational lines.

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10

Yunnikova, L. P., T. A. Akent'eva, and E. A. Yunnikova. "C- or N- functionalization of tropilia salt 2-amino-4-methylthiazole or 5-aminotetrazole." Журнал органической химии 59, no. 11 (2023): 1497–500. http://dx.doi.org/10.31857/s0514749223110125.

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The charges on the reaction centers of 2-amino-4-methylthiazole and 5-aminotetrazole, which predetermine their interaction with tropylium tetrafluoroborate, were determined by quantum chemical calculation (AM1) in accordance with the charge control of the process. New compounds 4-methyl-5-(cyclohepta-11,31,51-trienyl)-2-aminothiazole and 5-( N , N -dicyclohepta-11,31,51-trienyl)aminotetrazole were obtained.

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11

Svoboda, Ingrid, Hartmut Fuess, Uwe Bergstraesser, Sabine Altermann, and Jens Hartung. "Hindered rotation inN-(acyloxy)-4-methylthiazole-2(3H)-thiones." Acta Crystallographica Section A Foundations of Crystallography 65, a1 (2009): s270—s271. http://dx.doi.org/10.1107/s0108767309094288.

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12

Komarov, Igo V., Aleksandr V. Strizhak, Mikhail Yu Kornilov, Evgeniy Zarudnitskiy, and Andrey A. Tolmachev. "ChemInform Abstract: Direct Phosphorylation of Benzothiazoles and 4-Methylthiazole." ChemInform 31, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.200022057.

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13

Anuse, D. G., V. J. Desale, B. R. Thorat, et al. "Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes." Oriental Journal Of Chemistry 37, no. 1 (2021): 187–93. http://dx.doi.org/10.13005/ojc/370126.

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The substituted 2-Aminobenzothiazole and ethyl 2-(4-formyl-3-hydroxyphenyl)-4-methylthiazole-5-carboxylate in methanol mix together and heat the reaction mixture for overnight, It gives Schiff’s bases (derivatives of substituted aminobenzothiazole) 3. This compound 3 when treated with Zinc Chloride it gives Zinc metal complex of Schiff’s bases 4 and if compound 3 was treated with Lanthanum chloride gives Lanthanum metal complex of Schiff’s bases 5, which shows marked biological activities.

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14

Fong, Mei, Wit K. Janowski, Rolf H. Prager, and Max R. Taylor. "A Convenient Synthesis of 2-Substituted Thiazole-5-carboxylates." Australian Journal of Chemistry 57, no. 6 (2004): 599. http://dx.doi.org/10.1071/ch03252.

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The photolysis of ethyl 5-oxo-2-phenyl-2,5-dihydroisoxazole-4-carboxylate in acetonitrile containing 0.5% tri- fluoroacetic acid in the presence of thioamides gives moderate (40–60%) yields of thiazole-5-carboxylate esters. In the absence of trifluoroacetic acid, the intermediate vinyl thioesters can be isolated. That addition of the thioamide to the first formed carbene was, through sulfur, confirmed by X-ray crystal structures of 2-methylthiazole-5-carboxylic acid and a byproduct.

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15

Mori, Seiichiro, Takakazu Yamamoto, Naoki Asakawa, Koji Yazawa, and Yoshio Inoue. "The Dynamic Structure of Regioregulated Poly(4-methylthiazole-2,5-diyl)." Polymer Journal 40, no. 5 (2008): 475–78. http://dx.doi.org/10.1295/polymj.pj2007207.

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16

Hartung, Jens, Christine Schur, Irina Kempter, et al. "Hindered rotation in N-acyloxy-4-methylthiazole-2(3H)-thiones." Tetrahedron 65, no. 36 (2009): 7527–32. http://dx.doi.org/10.1016/j.tet.2009.06.124.

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17

Murai, Toshiaki, Kirara Yamaguchi, Teppei Hayano, et al. "Synthesis and Photophysical Properties of 5-N-Arylamino-4-methylthiazoles Obtained from Direct C–H Arylations and Buchwald–Hartwig Aminations of 4-Methylthiazole." Organometallics 36, no. 14 (2017): 2552–58. http://dx.doi.org/10.1021/acs.organomet.7b00128.

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18

de Mattos, Marcio, та Vitor de Andrade. "One-Pot Telescoped Synthesis of Thiazole Derivatives from β-Keto Esters and Thioureas Promoted by Tribromoisocyanuric Acid". Synthesis 50, № 24 (2018): 4867–74. http://dx.doi.org/10.1055/s-0037-1610243.

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A simple and efficient one-pot protocol has been developed for the synthesis of thiazole derivatives from readily available starting materials. Tribromoisocyanuric acid was successfully used for α-monohalogenation of β-keto esters in aqueous medium, which in the presence of thiourea and DABCO produced the corresponding 2-aminothiazoles in up to 87% yield. Extension of the reaction to thioacetamide and o-phenylenediamine led to 2-methylthiazole and quinoxalines, respectively. This approach enables telescoping of the two steps into a single process.

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19

Karthikeyan, V., V. Ramkumar, and R. Joel Karunakaran. "1′-Allyl-1-(3,4-dimethylbenzoyl)-2-(4-methyl-1,3-thiazol-5-yl)-1,2,5,6,7,7a-hexahydrospiro[pyrrolizine-3,3′-indolin]-2′-one." Acta Crystallographica Section E Structure Reports Online 70, no. 5 (2014): o541—o542. http://dx.doi.org/10.1107/s1600536814006990.

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In the title compound, C30H31N3O2S, the fused pyrrolidine ring bearing three substituents adopts an envelope conformation with the C atom bearing the benzoyl group as the flap. The other fused pyrrolidine ring adopts a twisted conformation about one of its C—C bonds. The dihedral angle between the isatin ring system and the methylthiazole ring is 25.95 (8)°. An intramolecular C—H...O interaction closes anS(8) ring. In the crystal, molecules are linked by C—H...O interactions, generatingC(11) chains propagating in [001].

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20

Xue, Rui Ting, Wei Song Sun, and Si Rong Yu. "Synthesis, Crystal Structure and Optical Properties of Silver Complex with 2-Amino-4-Methylthiazole." Advanced Materials Research 1096 (April 2015): 143–46. http://dx.doi.org/10.4028/www.scientific.net/amr.1096.143.

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The complex of 2-amino-4-methylthiazole with silver [Ag (C4H6N2S)2.(CH3)2CO] had been synthesized and characterized by elemental analysis, FT-IR and UV-vis spectra. Crystals of the complex were obtained through solvent diffusion method and the structure had been determined by single crystal X-ray diffraction. The nonlinear optical properties were investigated with the density functional theory method. The calculated results show that the complex has high hyperpolarizability of 316.8×10-30esu and the metal irons play an important role for the nonlinear optical properties.

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21

Wang, Qing Kai, Hong Jun Zang, Fang Yang, Bo Wen Cheng, Yuan Lin Ren, and Xian Lin Xu. "Syntheses and Investigation of Properties of New Ionic Liquids Thiazolium Halogenide." Advanced Materials Research 332-334 (September 2011): 2036–39. http://dx.doi.org/10.4028/www.scientific.net/amr.332-334.2036.

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A series of novel thiazolium halogenide ionic liquids were synthesized by using 4-methylthiazole or 4-methyl-5-thiazoleethanol and halohydrocarbons as materials. The compounds were characterized and analyzed by elemental analysis, 1H NMR and DSC.The solubilities of the ionic liquids in organic dissolvents were observed, meanwhile the conductivities and melting points were measured. The results show that these ionic liquids have high conductivity in water and have good solubility in traditional polar solvents, such as H2O, ethanol and acetonitrile. And the thiazolium halogenide are room tempera

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22

Demchenko, A. M., V. A. Chumakov, A. N. Krasovskii, V. V. Pirozhenko, and M. O. Lozinskii. "Imidazo[2,1-b]thiazolium salts based on 2-phenylamino-4-methylthiazole." Chemistry of Heterocyclic Compounds 33, no. 6 (1997): 728–31. http://dx.doi.org/10.1007/bf02291808.

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23

Manuilova, L. V., N. D. Parshukova, and T. S. Sukhareva. "Synthesis of 4-methylthiazole in the presence of acid-base catalysts." Reaction Kinetics & Catalysis Letters 58, no. 1 (1996): 155–60. http://dx.doi.org/10.1007/bf02071119.

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24

Hu, Hong, and Wei Song. "One-Step Fabrication of Methylthiazole-Functionalized Anion Exchange Membranes for Diffusion Dialysis." Open Journal of Physical Chemistry 08, no. 04 (2018): 100–109. http://dx.doi.org/10.4236/ojpc.2018.84007.

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25

Baddi, Sravan, Auphedeous Y. Dang-i, Tingting Huang, Chao Xing, Shuangjun Lin, and Chuan-Liang Feng. "Chirality-influenced antibacterial activity of methylthiazole- and thiadiazole-based supramolecular biocompatible hydrogels." Acta Biomaterialia 141 (March 2022): 59–69. http://dx.doi.org/10.1016/j.actbio.2022.01.033.

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26

Marsh, Wayne E., William E. Hatfield, and Derek J. Hodgson. "Structural characterization of dimeric and monomeric copper(II) complexes of 4-methylthiazole." Inorganic Chemistry 27, no. 10 (1988): 1819–22. http://dx.doi.org/10.1021/ic00283a028.

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27

Meng, Ge, Mei Wang, Aqun Zheng, Jianwei Dou, and Zengjun Guo. "Efficient one-pot synthesis of ethyl 2-substitued-4-methylthiazole-5-carboxylates." Green Chemistry Letters and Reviews 7, no. 1 (2014): 46–49. http://dx.doi.org/10.1080/17518253.2014.895858.

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28

Wu, Min, Xiu-Rong Hu, Jian-Ming Gu, and Gu-Ping Tang. "Crystal structure of febuxostat–acetic acid (1/1)." Acta Crystallographica Section E Crystallographic Communications 71, no. 5 (2015): o295—o296. http://dx.doi.org/10.1107/s2056989015005708.

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The asymmetric unit of the title compound [systematic name: 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid–acetic acid (1/1)], C16H16N2O3S·CH3COOH, contains a febuxostat molecule and an acetic acid molecule. In the febuxostat molecule, the thiazole ring is nearly coplanar with the benzene ring [dihedral angle = 3.24 (2)°]. In the crystal, the febuxostat and acetic acid molecules are linked by O—H...O, O—H...N hydrogen bonds and weak C—H...O hydrogen bonds, forming supramolecular chains propagating along theb-axis direction. π–π stacking is observed between nearly parallel t

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29

Dave, Medha D. "Dipole - Dipole Energy Transfer Reaction of 4-Methylthiazole and Benzophenone: Mechanism and Kinetics." IOSR Journal of Applied Chemistry 3, no. 1 (2012): 11–17. http://dx.doi.org/10.9790/5736-0311117.

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30

Kozisek, Jozef, Julia Koziskova, Lukáš Bučinský, Peter Herich, Jens Hartung, and Mike Müller. "Crystal and electronic structure of 3-(2′-tetrahydropyranyloxy)-4-methylthiazole-2(3H)-thione." Acta Crystallographica Section A Foundations and Advances 74, a2 (2018): e307-e307. http://dx.doi.org/10.1107/s2053273318090551.

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31

Chattopadhyay, Gautam, and Sikha Lahiri. "ChemInform Abstract: Synthesis of 2-(1,2-Disubstituted)hydrazino-4-methylthiazole-5-carboxylic Acids." ChemInform 30, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199945146.

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32

Hamada, Yasumasa, Osamu Hara, Taiju Nakamura, Fumihiko Sato, and Kazuishi Makino. "Palladium-catalyzed Cross-Coupling Reaction of 4-Methylthiazole and 2-Trimethylsilylthiazoles with Biaryl Triflates." HETEROCYCLES 68, no. 1 (2006): 1. http://dx.doi.org/10.3987/com-05-10570.

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33

Zhu, Xiong, Yue Wang, and Tao Lu. "2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid pyridine solvate." Acta Crystallographica Section E Structure Reports Online 65, no. 11 (2009): o2603. http://dx.doi.org/10.1107/s1600536809039002.

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34

Grabow, J. U., H. Hartwig, N. Heineking, et al. "The microwave spectrum of 2-methylthiazole: methyl internal rotation and 14N nuclear quadrupole coupling." Journal of Molecular Structure 612, no. 2-3 (2002): 349–56. http://dx.doi.org/10.1016/s0022-2860(02)00144-8.

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35

Hyengoyan, A. P., K. A. Eliazyan, V. A. Pivazyan, E. A. Khazaryan, and V. V. Dovlatyan. "Effect of Different Substituents on Amine-imine Tautomerism of 2-Amino-4-methylthiazole Derivatives." Chemistry of Heterocyclic Compounds 41, no. 8 (2005): 1062–65. http://dx.doi.org/10.1007/s10593-005-0280-7.

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36

Nguyen, Thuy, Vinh Van, Claudine Gutlé, et al. "The microwave spectrum of 2-methylthiazole: 14N nuclear quadrupole coupling and methyl internal rotation." Journal of Chemical Physics 152, no. 13 (2020): 134306. http://dx.doi.org/10.1063/1.5142857.

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37

Dovlatyan, V. V., K. A. Eliazyan, V. A. Pivazyan, E. A. Kazaryan, and A. P. Engoyan. "Thiazolecarboxylic Acid Derivatives. 1. N-Substituted 2-Amino-4-methylthiazole-5-carboxylic Acid Derivatives." Chemistry of Heterocyclic Compounds 40, no. 1 (2004): 84–89. http://dx.doi.org/10.1023/b:cohc.0000023773.23834.ba.

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38

Lee, Chi-Han, and Takakazu Yamamoto. "Synthesis of Liquid Crystals with Bent-Rod Structure: 4-Methylthiazole Derivatives with Nematic Phase." Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals 369, no. 1 (2001): 95–102. http://dx.doi.org/10.1080/10587250108030012.

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39

de Jongh, Leigh-Anne, Liliana Dobrzańska, Christoph E. Strasser, Helgard G. Raubenheimer, and Stephanie Cronje. "Imine-coordinated 2-Aminoazole Complexes of Au(I): Complicating Reactions and Verification of Products by Crystal Structure Determination." Zeitschrift für Naturforschung B 69, no. 11-12 (2014): 1073–87. http://dx.doi.org/10.5560/znb.2014-4187.

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Abstract When Au(I) is provided with endocyclic soft thioether or endocyclic hard amine, endocyclic borderline imine and exocyclic hard amine coordination sites, the softer borderline endocyclic imine coordination site is favored. This is demonstrated by the synthesis and structural characterization (IR, MS, 1H, 13C and 31P NMR experiments and single-crystal X-ray diffraction analysis) of 2-aminoazole (2-amino-4-methylthiazole, 2-aminobenzothiazole and 2- aminobenzimidazole) complexes of [AuPPh3]+ (1-3). An unusual ring opening is observed for the reaction of 2-aminothiazoline with [Au(NO3)PPh

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40

Krishna Reddy, Reddivari Chenna, Syed Rasheed, Devineni Subba Rao, Shaik Adam, Yellala Venkata Rami Reddy, and Chamarthi Naga Raju. "New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities." Scientific World Journal 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/682603.

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A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides8(a–e)/carbothioamides8(f–j)were accomplished for biological interest by the simple addition of active functionalized arylisocyanates7(a–e)/arylisothiocyanates7(f–j)with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile(4). Compound4was synthesized in high yields (94%) by the condensation reaction of febuxostat (1) with piperazine using a selective reagent such as propylphosphonic anhydride (T3P). Antiviral activity againstTobacco mosaic virus(TM

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41

Zavalishin, Maksim N., Alexey N. Kiselev, Alexandra K. Isagulieva, et al. "Shedding Light on Heavy Metal Contamination: Fluorescein-Based Chemosensor for Selective Detection of Hg2+ in Water." International Journal of Molecular Sciences 25, no. 6 (2024): 3186. http://dx.doi.org/10.3390/ijms25063186.

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This article discusses the design and analysis of a new chemical chemosensor for detecting mercury(II) ions. The chemosensor is a hydrazone made from 4-methylthiazole-5-carbaldehyde and fluorescein hydrazide. The structure of the chemosensor was confirmed using various methods, including nuclear magnetic resonance spectroscopy, infrared spectroscopy with Fourier transformation, mass spectroscopy, and quantum chemical calculations. The sensor’s ability in the highly selective and sensitive discovery of Hg2+ ions in water was demonstrated. The detection limit for mercury(II) ions was determined

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42

Pagacz-Kostrzewa, Magdalena, Daria Bumażnik, Stéphane Coussan, and Magdalena Sałdyka. "Structure, Spectra and Photochemistry of 2-Amino-4-Methylthiazole: FTIR Matrix Isolation and Theoretical Studies." Molecules 27, no. 12 (2022): 3897. http://dx.doi.org/10.3390/molecules27123897.

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The structure, tautomerization pathways, vibrational spectra, and photochemistry of 2-amino-4-methylthiazole (AMT) molecule were studied by matrix isolation FTIR spectroscopy and DFT calculations undertaken at the B3LYP/6-311++G(3df,3pd) level of theory. The most stable tautomer with the five-membered ring stabilized by two double C=C and C=N bonds, was detected in argon matrices after deposition. When the AMT/Ar matrices were exposed to 265 nm selective irradiation, three main photoproducts, N-(1-sulfanylprop-1-en-2-yl)carbodiimide (fp1), N-(1-thioxopropan-2-yl)carbodiimide (fp2) and N-(2-met

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43

Cho, Min Kyung, and Sang Geon Kim. "Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction with liver injury." Toxicology 146, no. 2-3 (2000): 111–22. http://dx.doi.org/10.1016/s0300-483x(00)00163-3.

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44

DEMCHENKO, A. M., V. A. CHUMAKOV, A. N. KRASOVSKII, V. V. PIROZHENKO, and M. O. LOZINSKII. "ChemInform Abstract: Imidazo[2,1-b]thiazolium Salts on the Basis of 2-Phenylamino-4-methylthiazole." ChemInform 29, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.199801138.

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45

Dighe, Rajendra Dnyandeo, Vinod A. Bairagi, Parag A. Pathade, and Yogesh T. Sonawane. "Virtual screening of synthesized thiazole derivatives for M. tuberculosis and dTDP-rhamnose inhibitors." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 207–10. http://dx.doi.org/10.22270/jddt.v9i1.2324.

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To determine antimycobacterium and dTDP rhamnose inhibitor activity of the synthesized azetidinone, thiazolidinone derivatives of thiazole, we studied different derivatives for the activity. One pot synthesis of 2-amino-4-methylthiazole-5-carboxylic acid ethyl ester has been carried out and synthesized different derivative compounds. Compounds were tested for antimicrobial activity against different strains of microorganism and antitubercular activity against M. tuberculosis H37Rv. Compounds 7c, 7d, 7i, 8d, 8e, 8g and 8h, were showed antimicrobial activity against Staphylococcus aureus, Escher

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46

Apryshko, G. N., O. S. Zhukova, L. V. Fetisova, N. K. Vlasenkova, R. B. Pugacheva, and O. V. Goryunova. "In silico and in vitro research of potential antineoplastic amino acid derivatives of indolocarbazol glycosides properties." Russian Journal of Biotherapy 16, no. 4 (2017): 46–54. http://dx.doi.org/10.17650/1726-9784-2017-16-4-46-54.

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Objective: to evaluate the prospects of the glycosides of indolocarbazole containing amino acid residues as potential antitumor compounds. Materials and methods. For 32 compounds by structural formulas using the methods of chemoinformatics, a number of molecular descriptors and the probability of manifestation of various types of biological activity were calculated, the cytotoxic activity was evaluated in vitro by methylthiazole tetrazolium (MTT) assay using five human tumor cell lines. Results. For the studied amino acid derivatives of glycosides of indolocarbazole, a high probability of anti

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47

Borde, Ramesh M., Satish B Jadhav, Rahul R Dhavse, and Achut S Munde. "DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL BIS-THIAZOLE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 4 (2018): 164. http://dx.doi.org/10.22159/ajpcr.2018.v11i4.23413.

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Abstract:

Objective: A series of substituted 5,2-bis-thiazoles derivatives were synthesized by Hantzsch reaction and evaluated in vitro for antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Methods: 2-(4-(benzyloxy)phenyl)-4-methylthiazole-5-carbothioamide were synthesized and allowed to react with various α-haloketones to give 5,2-bis-thiazoles, i.e., 2-(4-(benzyloxy)phenyl)-4-methyl-5-(4-substituted thiazol-2-yl)thiazole derivatives in excellent yield. The synthesized compounds were characterized by spectroscopic methods as well as e

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48

Hartung, Jens, Andreas Gross, and Uwe Bergsträsser. "5-(4-Chlorophenyl)-3-hydroxy-4-methylthiazole-2(3H)-thione: an instance of bifurcated hydrogen bonding." Acta Crystallographica Section E Structure Reports Online 63, no. 5 (2007): o2743—o2745. http://dx.doi.org/10.1107/s1600536807018016.

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Elchaninov, M. M., and A. A. Aleksandrov. "Synthesis and Reactivity of Fusion Product of 2-Methylthiazole Fragment to 2-(Furan-2-yl)benzimidazole." Russian Journal of Organic Chemistry 54, no. 8 (2018): 1200–1204. http://dx.doi.org/10.1134/s1070428018080134.

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Hartung, Jens, Christine Schur, Irina Kempter, and Thomas Gottwald. "Efficiency of alkoxyl radical product formation from 5-substituted 3-alkoxy-4-methylthiazole-2(3H)-thiones." Tetrahedron 66, no. 6 (2010): 1365–74. http://dx.doi.org/10.1016/j.tet.2009.11.113.

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