Relevant bibliographies by topics / Modèle BCRE

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Modèle BCRE'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Modèle BCRE"

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Zhao, Xingwang, Hengyi Xie, Meng Zhao, et al. "Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function." Science Advances 5, no. 7 (2019): eaaw0315. http://dx.doi.org/10.1126/sciadv.aaw0315.

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B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence of FcRL1 cross-linking, suggesting that FcRL1 may intrinsically regulate B cell activation and function. BCR cross-linking alone led to the phosphorylation of the intracellular Y281ENV motif of FcRL1 to provide a docking site for c-Abl, an SH2 domain-containing kinase. The FcRL1 an
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Chen, SJ, Z. Chen, CJ Larsen, and R. Berger. "Leucémies aiguës à chromosome Philadelphie : Un nouveau bcr et un modèle de recombinaison." médecine/sciences 5, no. 5 (1989): 282. http://dx.doi.org/10.4267/10608/3967.

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Wan, Haifeng, Lei Gao, Manman Su, Qirun Sun, and Lei Huang. "Attention-Based Convolutional Neural Network for Pavement Crack Detection." Advances in Materials Science and Engineering 2021 (April 7, 2021): 1–13. http://dx.doi.org/10.1155/2021/5520515.

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Achieving high detection accuracy of pavement cracks with complex textures under different lighting conditions is still challenging. In this context, an encoder-decoder network-based architecture named CrackResAttentionNet was proposed in this study, and the position attention module and channel attention module were connected after each encoder to summarize remote contextual information. The experiment results demonstrated that, compared with other popular models (ENet, ExFuse, FCN, LinkNet, SegNet, and UNet), for the public dataset, CrackResAttentionNet with BCE loss function and PRelu activ
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Kansy, Benjamin, Christian Wallwiener, Adam Kasperkowiak, et al. "Das klinische Breast Cancer Recruitment Module (BCRM) – Online-Screening-Instrument zur Unterstützung von Tumorkonferenzen." Senologie - Zeitschrift für Mammadiagnostik und -therapie 9, no. 03 (2012): 155–57. http://dx.doi.org/10.1055/s-0032-1318915.

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Carofiglio, Francesca, Daniela Trisciuzzi, Nicola Gambacorta, Francesco Leonetti, Angela Stefanachi, and Orazio Nicolotti. "Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to." Molecules 25, no. 18 (2020): 4210. http://dx.doi.org/10.3390/molecules25184210.

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The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition regulatory module observed in the progenitor kinase c-Abl is lost in the aberrant Bcr-Abl, because of the lack of the N-myristoylated cap able to bind the myristoyl binding pocket also conserved in the Bcr-Abl kinase domain. A way to overcome the occurrence of resistance phenomena frequently observed for Bcr-Abl orthosteric drugs is the rational design of allosteric ligands approaching the so-called myristoyl binding pocket. The discovery
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Mclaurin, Justin D., and Orion D. Weiner. "Multiple sources of signal amplification within the B-cell Ras/MAPK pathway." Molecular Biology of the Cell 30, no. 13 (2019): 1610–20. http://dx.doi.org/10.1091/mbc.e18-09-0560.

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The Ras-Map kinase (MAPK) cascade underlies functional decisions in a wide range of cell types and organisms. In B-cells, positive feedback-driven Ras activation is the proposed source of the digital (all or none) MAPK responses following antigen stimulation. However, an inability to measure endogenous Ras activity in living cells has hampered our ability to test this model directly. Here we leverage biosensors of endogenous Ras and ERK activity to revisit this question. We find that B-cell receptor (BCR) ligation drives switch-like Ras activation and that lower BCR signaling output is require
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Reth, Michael, and Michael R. Gold. "What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling." European Journal of Immunology 46, no. 11 (2016): 2507–11. http://dx.doi.org/10.1002/eji.201646705.

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Ansari, Shahab U., Kamran Javed, Saeed Mian Qaisar, Rashad Jillani, and Usman Haider. "Multiple Sclerosis Lesion Segmentation in Brain MRI Using Inception Modules Embedded in a Convolutional Neural Network." Journal of Healthcare Engineering 2021 (August 4, 2021): 1–10. http://dx.doi.org/10.1155/2021/4138137.

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Multiple sclerosis (MS) is a chronic and autoimmune disease that forms lesions in the central nervous system. Quantitative analysis of these lesions has proved to be very useful in clinical trials for therapies and assessing disease prognosis. However, the efficacy of these quantitative analyses greatly depends on how accurately the MS lesions have been identified and segmented in brain MRI. This is usually carried out by radiologists who label 3D MR images slice by slice using commonly available segmentation tools. However, such manual practices are time consuming and error prone. To circumve
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Papakonstantinou, Nikos, Jana Gutwein, Ole Ammerpohl, et al. "CLL Subsets with Distinct Stereotyped B Cell Receptors Have Distinct Epigenetic Make-up, Even Beyond IGHV Gene Mutational Status: DNA Methylation Profiling of IGHV-Unmutated CLL Stereotyped Subsets #6 and #8." Blood 120, no. 21 (2012): 3869. http://dx.doi.org/10.1182/blood.v120.21.3869.3869.

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Abstract Abstract 3869 In CLL, subsets of patients with stereotyped B cell receptors (BcRs) account for one-third of the cohort. Increasing evidence suggests that cases assigned to the same subset can share similar biological and clinical features independently of IGHV gene mutational status, at least for selected major subsets. Consequently, the study of BcR stereotypy has important implications for refining patient stratification with the ultimate aim of implementing targeted therapy and, eventually, improving outcome. CLL stereotyped subsets #6 (IGHV1–69/IGKV3–20) and #8 (IGHV4–39/IGKV1(D)-
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Jin, Yuwei, Wenbo Xu, Zhongwen Hu, Haitao Jia, Xin Luo, and Donghang Shao. "GSCA-UNet: Towards Automatic Shadow Detection in Urban Aerial Imagery with Global-Spatial-Context Attention Module." Remote Sensing 12, no. 17 (2020): 2864. http://dx.doi.org/10.3390/rs12172864.

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As an inevitable phenomenon in most optical remote-sensing images, the effect of shadows is prominent in urban scenes. Shadow detection is critical for exploiting shadows and recovering the distorted information. Unfortunately, in general, automatic shadow detection methods for urban aerial images cannot achieve satisfactory performance due to the limitation of feature patterns and the lack of consideration of non-local contextual information. To address this challenging problem, the global-spatial-context-attention (GSCA) module was developed to self-adaptively aggregate all global contextual
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Dissertations / Theses on the topic "Modèle BCRE"

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ARADIAN, Achod André. "Quelques problèmes de dynamique d'interfaces molles." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2001. http://tel.archives-ouvertes.fr/tel-00001386.

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Ce travail de thèse, de nature théorique, présente quatre axes de recherche portant sur la dynamique d'interfaces molles. (1) Gouttes et films de liquide sur substrats poreux : Nous avons étudié la déformation d'une goutte soumise simultanément à une aspiration de liquide et à un ancrage de sa ligne de contact avec le substrat. Nous nous sommes aussi intéressés au problème de l'entraînement d'un film de liquide sur une surface poreuse tirée hors d'un bain : le film a une hauteur finie, que nous avons calculée, et présente une structure non-triviale à l'approche de la ligne de contact. (2) Réti
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Fonte, Coralie. "Effets de différents modèles de stress sur le développement lymphocytaire." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0185/document.

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Les vols spatiaux sont source de nombreux stress conduisant à un affaiblissement du système immunitaire. L’efficacité de ce système repose notamment sur la diversité des répertoires de récepteurs aux antigènes présents à la surface des lymphocytes B (BCR) et T (TCR) permettant de reconnaitre un grand nombre d’antigènes différents. Au cours de cette thèse, j’ai étudié la diversité des récepteurs à l’antigène dans trois modèles animaux différents : l’amphibien Pleurodeles waltl, le modèle murin de suspension anti‐orthostatique (micropesanteur simulée) et le modèle murin CUMS (pour « Chronic Unpr
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Dauphin, Véronique. "Hétérogénéité clonale des cellules leucémiques Bcr-Abl+ résistantes à la lyse NK : établissement d'un modèle in vitro." Lille 2, 2010. http://www.theses.fr/2010LIL2S061.

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Le phénomène de "dormance tumorale" désigne la situation où un petit nombre de cellules tumorales persisitent en équilibre avec l'hôte pendant une période prolongée, sans que la tumeur ne croisse. Ce phénomène peut exister au décours d'un traitement cytotoxique sous forme d'une maladie résiduelle et est objectivé par des rechutes survenant parfois plusieurs décennies après le diagnostic initial. Après avoir transfecté bcr-abl humain à une lignée myéloïde, le laboratoire a développé un modèle de dormande tumorale qui a démontré que ces cellules (i) sont partiellement résistantes à l'imatinib, (
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Coppo, Paul. "Mise au point d'un modèle de cellules souches transformées par l'oncogène BCR-ABL : conséquences sur la différenciation et l''autorenouvellement." Paris 7, 2006. http://www.theses.fr/2006PA077224.

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La leucémie myéloïde chronique (LMC) est une affection maligne clonale de la cellule souche hématopoïétique caractérisée par la présence du chromosome Philadelphie (ou Phi), issu de la translocation entre les chromosomes 9 et 22. Celui-ci génère l'oncoprotéine BCR-ABL ayant une activité tyrosine kinase constitutive. Actuellement, les mécanismes précis de l'expansion myéloïde, de l'autorenouvellement du clone leucémique, et du blocage de la différenciation lors de la crise blastique observés dans la LMC restent inconnus. Afin d'étudier les mécanismes par lesquels BCR-ABL pourrait orienter la de
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Atack, Carol Wendy. "Debating kingship : models of monarchy in fifth- and fourth-century BCE Greek political thought." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708051.

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DUGRAY, AYMERIC. "Controle de l'hematopoiese maligne a l'aide de retrovirus a promoteurs inductibles : modele de leucemogenese par bcr-abl." Paris 7, 2001. http://www.theses.fr/2001PA077133.

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Les phenomenes moleculaires qui sont responsables de la progression du clone leucemique ph1 vers la phase blastique au cours de la leucemie myeloide chronique sont indetermines. Ce travail a consiste a modeliser un des aspects phenotypiques de cette progression qui consiste en l'augmentation de l'expression de bcr-abl. Dans ce but, nous avons genere un modele de leucemogenese a l'aide d'un systeme retroviral a promoteur inductible gouvernant l'expression du gene bcr-abl. Ce retrovirus inductible a permis la transduction de la lignee hematopoietique ba/f3 avec obtention de clones uniques dans l
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Rousseau, Emilie. "Identification des gènes impliqués dans la coopération oncogénique avec BCR-ABL1 dans la Leucémie Myéloïde Chronique." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0281.

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La leucémie myéloïde chronique (LMC) a été le premier cancer humain associé à une anomalie chromosomique : le chromosome de Philadelphie. Le gène de fusion BCR-ABL1 résultant code pour une tyrosine kinase ayant une activité dérégulée. Les inhibiteurs de tyrosine kinase (ITKs), qui inactivent la protéine BCR-ABL1, représentent la thérapie ciblée la plus efficace pour la LMC en phase chronique. Cependant, la LMC en phase avancée ne répond pas bien au traitement par les ITKs. Les mécanismes sous-jacents à la progression de la LMC ne sont pas bien compris. Par conséquent, la découverte de gènes qu
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Daubon, Thomas. "Mobilité cellulaire induite par les chimères Bcr-Abl : un nouveau modèle pour l'exploration des voies effectrices des petites protéines G de la famille Rho." Poitiers, 2008. http://theses.edel.univ-poitiers.fr/theses/2008/Daubon-Thomas/2008-Daubon-Thomas-These.pdf.

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Les chimères Bcr-Abl sont dues à une translocation réciproque entre les chromosomes 9 et 22, entrainant la fusion des gènes bcr et abl. La seule différence structurale entre p190bcr﷓abl, associé avec la Leucémie Aigue Lymphoblastique, et p210bcr-abl, responsable de la Leucémie Myéloïde Chronique, réside dans le domaine DH/PH présent uniquement dans p210bcr-abl. Nous avons montré précédemment que Rac1 était activée dans les cellules exprimant p190bcr-abl et p210bcr-abl alors que RhoA n’est activé que dans les cellules exprimant p210bcr-abl (Harnois et al. , Oncogene, 2003). Les cellules Ba/F3 p
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Zdiri, Mustapha. "Etude de formulation et de comportement mécanique des Bétons Compactés au Rouleau (BCR) : Applications routières - Cas des matériaux de gisements locaux." Artois, 2008. http://www.theses.fr/2008ARTO0202.

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Le présent travail de recherche comporte une étude sur le Béton Compacté au Rouleau (BCR) en vue d'une application en technique routière et en utilisant des matériaux de gisements locaux avec la spécificité d’un faible dosage en ciment. L'étude a traité le problème de formulation à travers les méthodes graphiques, semi-empiriques et le Modèle d'Empilement Compressible MEC. On a introduit aussi dans ce travail, l’utilisation des granulats spéciaux du type Sidérite et l'addition des adjuvants dans la formulation du BCR. La rhéologie du BCR frais et la sensibilité de ce mélange au phénomène de
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Geay, Jean-François. "Rôle d’un oncogène dans la circulation des cellules malignes : influence de Bcr-Abl sur la fonction et l’expression du récepteur chimiokine CXCR4 dans le modèle de la leucémie myéloïde chronique." Paris 7, 2005. http://www.theses.fr/2005PA077222.

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La leucémie myéloïde chronique (LMC) est un syndrome myéloprolifératif qui se manifeste par la présence de la protéine cytoplasmique Bcr-AbI, responsable de la malignisation des cellulles. En particulier, la maladie se caractérise par la circulation anormale dans le sang des progéniteurs hématopoïétiques malins qui quittent prématurément la moelle osseuse, donnant lieu à une myélémie. Les bases moléculaires de ce phénomène sont encore peu connues. La chimiokine SDF-1 et son récepteur CXCR4 sont des éléments clés dans la régulation de la circulation des cellules hématopoïétiques normales. Ils j
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Books on the topic "Modèle BCRE"

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Eppihimer, Melissa. Exemplars of Kingship. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190903015.001.0001.

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The Akkadian kings (ca. 2334–2154 BCE) created the first territorial state in the ancient Near East and were remembered as model kings for more than two millennia thereafter. Exemplars of Kingship: Art, Tradition, and the Legacy of the Akkadians evaluates how later rulers engaged with Akkadian visual models and memories of Akkadian kingship in their own images. Through analyses of post-Akkadian victory monuments, votive statues, cylinder seals, and other works of art, the book explores the intersection of visual traditions and cultural memory in ancient Mesopotamia. Exemplars of Kingship also
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Tilly, Charles. States, State Transformation, and War. Edited by Jerry H. Bentley. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780199235810.013.0011.

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This article employs a stripped-down model of a state: a ruler, an apparatus of rule, a subject population, and external interactions of various sorts, from trade, diplomacy, and mass migration to war. It aims to identify common properties and systematic variations among states, including their involvement in war. First, using the example, of Tiglath-pileser I (ruler of Assyria, 1114–1076 bce), it places Middle Eastern empires in a much wider range of states across the entire world from the state's first emergence toward 3000 bce to the present. The rest of the discussion proceeds through four
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Whitmarsh, Tim. The Romance of Zarinaea and Stryangaeus. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199742653.003.0006.

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Another ‘romance’ that was clearly influential on later Greek novels was the story of Zarinaea and Stryangaeus, first recounted (in Greek) in Ctesias’s Persica (early fourth century BCE). A fragment of a heavily novelistic version by Nicolaus of Damascus survives from the time of Augustus. This shows that erotic romance existed, and pre-existed, in forms different from the Hellenocentric mode adopted by Chariton and his immediate successors.
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Frangipane, Marcella. Arslantepe-Malatya: A Prehistoric and Early Historic Center in Eastern Anatolia. Edited by Gregory McMahon and Sharon Steadman. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376142.013.0045.

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This article discusses findings from excavations at Arslantepe–Malatya. Arslantepe is a tell about 4.5 hectares in extension and 30 meters high, at the heart of the fertile Malatya Plain, some 12 kilometers from the right bank of the Euphrates, and surrounded by mountains, which, in the past, were covered by forests. In the earliest phases of its history, in the Chalcolithic period, it had close links with the Syro-Mesopotamian world, with which it shared many cultural features, structural models, and development trajectories. But in the early centuries of the third millennium BCE, far-reachin
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Bernard, Seth. A Cost Analysis of the Republican Circuit Walls. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190878788.003.0004.

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This chapter analyzes the social and economic effects of the single largest construction project of pre-Imperial Rome, the circuit of walls built in the first half of the fourth century BCE. I employ an “energetics” approach (Abrams 1994), quantifying the labor-cost of the walls’ construction by means of comparative data and close study of the monument’s remains. The resulting model provides a better idea not only of the walls’ total cost, but of the workforce’s composition, the balance of skilled and unskilled labor, and the schedule of construction. The costs are then input into a general mo
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Lewis, Sian. Tyrants, Letters, and Legitimacy. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198804208.003.0004.

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The chapter explores the part played by letters in how tyrants in the world of fifth- and fourth-century BCE Greece exercised power, with a specific emphasis on processes of decision-making and the role of state institutions that embedded the ruler within the wider political community. The focus is on the place and function of letters in the traditions surrounding the rulers of Syracuse (Dionysius I and II, Timoleon, and, moving into the Hellenistic period, Agathocles). A nuanced picture emerges: whereas the classical tyrants did not attempt to impose a model of rule through written communicat
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Wallace, Shane. Alexander the Great and Democracy in the Hellenistic World. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198748472.003.0003.

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This chapter looks at how Alexander the Great was remembered by democratic regimes in both Athens and Asia Minor in the early Hellenistic period. It argues that while Alexander’s reputation as a patron of democracy remained remarkably consistent in Asia Minor—his example was invoked as late as the first century BCE—he could be remembered in Athens as both a threat to, and a guarantor of, democracy. The reasons are twofold. First, Alexander supported tyrannies/oligarchies in Greece and democracies in Asia Minor. Second, his memory was employed in different ways by both kings and cities dependin
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Osborne, James F. The Syro-Anatolian City-States. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780199315833.001.0001.

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This book presents a new model for the kingdoms that clustered around the northeast corner of the Mediterranean Sea during the Iron Age, ca. 1200–600 BCE. Rather than presenting them as an ancient version of the modern nation-state, characterized by homogenous ethnolinguistic communities like “the Aramaeans” or “the Luwians” living in neatly bounded territories, this book presents these polities as being fundamentally diverse and variable, distinguished by demographic fluidity and cultural mobility. This conclusion is reached via an examination of a host of evidentiary sources, including site
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McGovern, Nathan. The Snake and the Mongoose. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190640798.001.0001.

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This book turns the commonly accepted model of the origins of the early Indian religions on its head. Since the beginning of modern Indology in the 19th century, the relationship between the major early Indian religions of Buddhism, Jainism, and Hinduism has been based on an assumed dichotomy between two metahistorical identities: “the Brahmans” and the newer “non-Brahmanical” śramaṇa movements. Textbook and scholarly accounts typically purport an “opposition” between these two groups by citing the 2nd century BCE Sanskrit grammarian Patañjali, often stating erroneously that he compared their
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Frampton, Stephanie Ann. Empire of Letters. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190915407.001.0001.

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Empire of Letters studies representations of texts and media in Roman authors from Lucretius to Ovid (c. 55 BCE–15 CE) in order to demonstrate how ancient writers conceived of the world, their work, and their own identities through material forms of writing. Drawing together methods of interpretation from a wide variety of fields (including Greek and Latin philology, epigraphy, papyrology, manuscript studies, literary criticism, media theory, and book history) and uniting close readings of major authors with the careful analysis of the physical forms inhabited by ancient texts (papyrus bookrol
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Book chapters on the topic "Modèle BCRE"

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Janes, Matthew R., and David A. Fruman. "The In Vivo Evaluation of Active-Site TOR Inhibitors in Models of BCR-ABL+ Leukemia." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-430-8_15.

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Williams, Richard T., and Charles J. Sherr. "The Arf Tumor Suppressor in Acute Leukemias: Insights from Mouse Models of Bcr–Abl-Induced Acute Lymphoblastic Leukemia." In Advances In Experimental Medicine And Biology. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-69116-9_9.

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Gupta, Pranav, Yunali V. Ashar, Charles R. Ashby, Lusheng Lin, and Zhe-Sheng Chen. "The Oncogenic Protein, Breakpoint Cluster (BCR)-Abelson Kinase (ABL) and Chronic Myelocytic Leukemia (CML): Insight Into the Drug Resistance Mechanisms and Approaches for Targeting BCR-ABL in CML." In Reference Module in Biomedical Sciences. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-820472-6.00047-5.

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Naglak, Matthew C., and Nicola Terrenato. "Central Italian Elite Groups as Aristocratic Houses in the Ninth to Sixth Centuries BCE." In Roman Law before the Twelve Tables. Edinburgh University Press, 2020. http://dx.doi.org/10.3366/edinburgh/9781474443968.003.0003.

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This chapter demonstrates the applicability of C. Lévi-Strauss’s “House Society” model for considering the role of kinship in the early moments of state formation and urbanization in Iron Age Latium and Etruria. After a brief theoretical overview of the model, the discussion focuses on two main axioms which are often overlooked in the model’s application to the ancient world: (1) a physical house does not make a social House, and (2) a single House does not make a Society. This is followed by an overview of how material evidence from sites ranging from Vetulonia to Osteria dell’Osa and textual evidence from the Twelves Tables can be interpreted through the lens of a “House Society” to create new models for the development of complex social systems in central Italy.
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Parkinson, R. B. "Libraries in Ancient Egypt, c.2600–1600 BCE." In Libraries before Alexandria. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780199655359.003.0003.

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This chapter surveys the textual and archaeological evidence for libraries in ancient Egypt c.2600–1600 BCE, discussing surviving administrative ‘archives’ as models for how literary texts could have been circulated and stored. The implications of the material form of surviving manuscripts for issues of manufacture and storage are discussed. Possible evidence for extensively centralized systems of circulation and storage is reviewed, together with specific case studies of private archives form the town of el-Lahun and examples of Middle Kingdom tomb-libraries—collections of manuscripts deposited in private individual’s burial chambers as displays of culture and prestige.
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Ochoa, Guillermo Acosta. "Early Agricultural Modes of Production in Mesoamerica." In Modes of Production and Archaeology. University Press of Florida, 2017. http://dx.doi.org/10.5744/florida/9780813054308.003.0004.

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The revolution in food production has been a recurring topic in archaeology. This chapter discusses some of the processes preceding the origins of food production and presents new findings from the State of Chiapas and the Basin of Mexico. The domestication of plants can be traced back to the early Holocene (ca. 10,000–8,000 BCE), but it is only in the period between 6,000 and 5,000 BCE when a radical change in the human modification of the environment, the emergence of the first sedentary societies in the Basin of Mexico, and the appearance of an extensive agricultural system in the lowlands of Middle America took place. These changes cannot be explained exclusively from the analysis of the mode of production. The mode of reproduction and the ecological history of the first agricultural communities should also be taken into account.
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Nail, Thomas. "Centripetal Motion." In Being and Motion. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190908904.003.0016.

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This chapter argues that being is in motion, but that motion appears first and foremost historically as space. During the period of time roughly defined as the Neolithic (10,000 BCE–5000 BCE), movement begins to take on a certain dominant mode of distribution or circulation, defined by an inward trajectory from the periphery toward a center. This centripetal motion is the condition for the dominant description of being’s motion as fundamentally spatial. This chapter describes the defining features of centripetal motion, which is an entirely real and kinetic condition, not a metaphysical concept. The centripetal motion of being is the condition for the ontological description of being as space, and its inscription through speech.
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Jillions, John A. "Roman Corinth." In Divine Guidance. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190055738.003.0002.

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This chapter gives the historical background of Corinth, its destruction by Roman forces in 146 BCE, and its establishment as a model Roman colony in 44 BCE. When Paul was there in the mid-first century it was a bustling crossroads of commerce and ideas. Archeology shows that Corinthian culture was still feeling the effects of the Roman Revolution under Augustus, which brought a distinctly Roman emphasis to all aspects of religion and society. Augustus himself had been very conscious of divine signs surrounding his elevation and rule. This had a marked effect on attitudes toward divine guidance in public worship and in household piety. In settings both public and private close observance of the religious traditions of Rome (whether or not one believed in them) was viewed as essential to Roman unity and prosperity. This piety was self-consciously Roman, emphasizing simplicity, virtue, and service to the community and state.
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Robinson, Elizabeth C. "Conclusion." In Urban Transformation in Ancient Molise. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190641436.003.0007.

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This chapter emphasizes the elements of continuity that have emerged from the consideration of multiple types of evidence. It answers the three questions posed in the introduction, and refers back to the three theoretical models adopted in the analysis. It discusses the ways that the results of this site biography differ from previously published studies while at the same time providing a synthesis of Larinum’s history from 400 bce to 100 ce. It then examines the ways in which Larinum is representative or anomalous when compared to other Italian towns. It also compares this local-level case study of Larinum to the conclusions of other local-level studies, especially ones that focus on the site of Taranto. It concludes by making the case for the creation of more local-level site biographies, using the study of Larinum as a model. It pushes the field of Roman conquest studies toward a new paradigm of social change that is contingent on highly specific, local issues, rather than global movements.
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Moore, Christopher. "Fifth-Century Philosophoi." In Calling Philosophers Names. Princeton University Press, 2019. http://dx.doi.org/10.23943/princeton/9780691195056.003.0005.

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This chapter draws on the fifth-century BCE uses of philosophos and cognates for two purposes: as corroboration for the coinage meaning set out in Chapter 3 and the connection to Pythagoreans set out in Chapter 4, and as description of the drift in meaning the term underwent across several generations of use. It focuses on six authors, each of whom use the term once: Herodotus, Thucydides, the Hippocratic author of On Ancient Medicine, Gorgias, Aristophanes, and Lysias. Burkert already referred to these authors in his observation that philosophos did not first mean “lacking wisdom” or “spectating the universe.” Treated, however, in their respective literary and rhetorical contexts, they provide significant information about the fifth-century BCE career of the idea of being philosophos. It appears that at the end of that century, the term sometimes loses its wry implication and names a quite specific mode of dialectic exchange about matters of abstract or broad significance.
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Conference papers on the topic "Modèle BCRE"

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Fruth, Florian, Damian M. Vogt, and Torsten H. Fransson. "Influence of the Blade Count Ratio on Aerodynamic Forcing: Part II—High Pressure Transonic Turbine." In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-46071.

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The influence of the Blade Count Ratio (BCR) on the aerodynamic forcing of a transonic high pressure turbine has been investigated numerically. Main focus here was put on the change in unsteady aerodynamics, modal properties and the mode excitation. Using a scaling technique, six different transonic turbine stages with different numbers of scaled blades but maintained steady aerodynamics were generated and further analyzed. In the analysis a non-linear, time marching CFD solver was used and the unsteady, harmonic forces projected onto the mode shapes. For this transonic turbine the unsteady pr
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Li, Jing, and Robert E. Kielb. "Effects of Blade Count Ratio on Aerodynamic Forcing and Mode Excitability." In ASME Turbo Expo 2015: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/gt2015-43304.

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The effects of blade count ratio (BCR) on both the steady and unsteady blade loading and the sensitivity of generalized force to a change in mode shape (mode excitability) are studied numerically on two 2D configurations: a subsonic research compressor stage and a turbine stage with supersonic exit. Using the Harmonic Balance method, only a single passage is modeled to represent the actual blade count in a row at a high level of computational efficiency. BCR variation is achieved by scaling the downstream airfoils with a fixed chord-to-pitch ratio, thus preserving the steady-state aerodynamics
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Karayaka, Metin, Atle Steen, Roy Shilling, and Rod Edwards. "Characterization of the Dynamic Loads Between Spar Top-Tensioned Riser Buoyancy Cans and Hull: Horn Mountain Field Data Measurements and Predictions." In ASME 2004 23rd International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/omae2004-51198.

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The Buoyancy Can Riser Tensioner (BCRT) systems are designed to provide tension to Top-Tensioned Risers (TTRs). BCRT systems do not transfer the riser weight to the floater and they minimize the interaction between the floating platform and the riser system. For deepwater field developments, this attractive feature allows efficient design of the floaters as well as the riser systems. Although, the vertical riser load is not transferred to the hull, the BCRT system makes lateral contact with the hull at several locations. During the past 3 years, analytical models have been developed to charact
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Li, Yousun, Heedo Yun, Jane Q. Zhang, Shankar Bhat Aramanadka, and Heping Zhang. "Dynamic and Frictional Interaction Between Buoyancy Can Riser Tensioner System and SPAR Hull." In ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67143.

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Buoyancy Can Riser Tensioner (BCRT) systems provide tension to the Top Tensioned Riser (TTR) systems. The main benefit of employing BCRT is that it can minimize the interaction between the floating platform and riser system. The possible lateral impact and dynamic loads which may occur between the SPAR hull and BCRT are minimized by placing the so-called Compliant Guides (CGs) at the sliding interfaces. The CGs are designed to allow relatively free sliding of the BCRT in the riser axial direction, while preventing/minimizing lateral impact loads by providing lateral compliance. CGs are made of
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Fruth, Florian, Damian M. Vogt, Hans Ma˚rtensson, Mari´a A. Mayorca, and Torsten H. Fransson. "Influence of the Blade Count Ratio on Aerodynamic Forcing: Part I—Highly Loaded Transonic Compressor." In ASME Turbo Expo 2010: Power for Land, Sea, and Air. ASMEDC, 2010. http://dx.doi.org/10.1115/gt2010-22756.

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The influence of the Blade Count Ratio (BCR) on the aerodynamic forcing of a highly transonic compressor has been investigated. The focus has been put on the unsteady aerodynamics as well as mode excitability and thus High Cycle Fatigue (HCF) risk. A number of compressor stages were investigated that differed in blade count of the stator blade row. Time-resolved aerodynamic forcing results were acquired using a non-linear CFD approach. The results were decomposed into frequency content and combined with modal properties of the various components. It is found that the BCR is a key parameter to
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Tanaka, Masaaki, and Satoshi Murakami. "Development of Numerical Estimation Method Using Spatial Connection Methodology for Thermal Striping in Upper Plenum of Reactor Vessel of an Advanced Loop-Type Sodium-Cooled Fast Reactor in Japan." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-67876.

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Thermal striping on the core instrumentation plate (CIP) at the bottom of the upper internal structure (UIS) of an advanced loop-type sodium-cooled fast reactor in Japan (Advanced-SFR) has been numerically investigated. At the top of the core below the CIP, the sodium at high temperature flows out from the fuel subassemblies (FSs) and the sodium at low temperature flows out from the primary control rod (PCR) and backup control rod (BCR) channels, and also the radial blanket fuel subassemblies (RBFSs) at the outer side of the core. In order to predict the thermal striping on the CIP caused by m
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Balsas, Patricia, Jocabed Roldan, Laura Jimenez, et al. "Abstract 5317: Preclinical evaluation of IQS019, a novel BCR kinase inhibitor, in in vitro and in vivo models of non-Hodgkin lymphoma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5317.

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