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Journal articles on the topic 'Modèle BCRE'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Zhao, Xingwang, Hengyi Xie, Meng Zhao, et al. "Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function." Science Advances 5, no. 7 (2019): eaaw0315. http://dx.doi.org/10.1126/sciadv.aaw0315.

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B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence of FcRL1 cross-linking, suggesting that FcRL1 may intrinsically regulate B cell activation and function. BCR cross-linking alone led to the phosphorylation of the intracellular Y281ENV motif of FcRL1 to provide a docking site for c-Abl, an SH2 domain-containing kinase. The FcRL1 an

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Chen, SJ, Z. Chen, CJ Larsen, and R. Berger. "Leucémies aiguës à chromosome Philadelphie : Un nouveau bcr et un modèle de recombinaison." médecine/sciences 5, no. 5 (1989): 282. http://dx.doi.org/10.4267/10608/3967.

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Wan, Haifeng, Lei Gao, Manman Su, Qirun Sun, and Lei Huang. "Attention-Based Convolutional Neural Network for Pavement Crack Detection." Advances in Materials Science and Engineering 2021 (April 7, 2021): 1–13. http://dx.doi.org/10.1155/2021/5520515.

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Achieving high detection accuracy of pavement cracks with complex textures under different lighting conditions is still challenging. In this context, an encoder-decoder network-based architecture named CrackResAttentionNet was proposed in this study, and the position attention module and channel attention module were connected after each encoder to summarize remote contextual information. The experiment results demonstrated that, compared with other popular models (ENet, ExFuse, FCN, LinkNet, SegNet, and UNet), for the public dataset, CrackResAttentionNet with BCE loss function and PRelu activ

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Kansy, Benjamin, Christian Wallwiener, Adam Kasperkowiak, et al. "Das klinische Breast Cancer Recruitment Module (BCRM) – Online-Screening-Instrument zur Unterstützung von Tumorkonferenzen." Senologie - Zeitschrift für Mammadiagnostik und -therapie 9, no. 03 (2012): 155–57. http://dx.doi.org/10.1055/s-0032-1318915.

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Carofiglio, Francesca, Daniela Trisciuzzi, Nicola Gambacorta, Francesco Leonetti, Angela Stefanachi, and Orazio Nicolotti. "Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to." Molecules 25, no. 18 (2020): 4210. http://dx.doi.org/10.3390/molecules25184210.

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The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition regulatory module observed in the progenitor kinase c-Abl is lost in the aberrant Bcr-Abl, because of the lack of the N-myristoylated cap able to bind the myristoyl binding pocket also conserved in the Bcr-Abl kinase domain. A way to overcome the occurrence of resistance phenomena frequently observed for Bcr-Abl orthosteric drugs is the rational design of allosteric ligands approaching the so-called myristoyl binding pocket. The discovery

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Mclaurin, Justin D., and Orion D. Weiner. "Multiple sources of signal amplification within the B-cell Ras/MAPK pathway." Molecular Biology of the Cell 30, no. 13 (2019): 1610–20. http://dx.doi.org/10.1091/mbc.e18-09-0560.

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The Ras-Map kinase (MAPK) cascade underlies functional decisions in a wide range of cell types and organisms. In B-cells, positive feedback-driven Ras activation is the proposed source of the digital (all or none) MAPK responses following antigen stimulation. However, an inability to measure endogenous Ras activity in living cells has hampered our ability to test this model directly. Here we leverage biosensors of endogenous Ras and ERK activity to revisit this question. We find that B-cell receptor (BCR) ligation drives switch-like Ras activation and that lower BCR signaling output is require

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Reth, Michael, and Michael R. Gold. "What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling." European Journal of Immunology 46, no. 11 (2016): 2507–11. http://dx.doi.org/10.1002/eji.201646705.

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Ansari, Shahab U., Kamran Javed, Saeed Mian Qaisar, Rashad Jillani, and Usman Haider. "Multiple Sclerosis Lesion Segmentation in Brain MRI Using Inception Modules Embedded in a Convolutional Neural Network." Journal of Healthcare Engineering 2021 (August 4, 2021): 1–10. http://dx.doi.org/10.1155/2021/4138137.

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Multiple sclerosis (MS) is a chronic and autoimmune disease that forms lesions in the central nervous system. Quantitative analysis of these lesions has proved to be very useful in clinical trials for therapies and assessing disease prognosis. However, the efficacy of these quantitative analyses greatly depends on how accurately the MS lesions have been identified and segmented in brain MRI. This is usually carried out by radiologists who label 3D MR images slice by slice using commonly available segmentation tools. However, such manual practices are time consuming and error prone. To circumve

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Papakonstantinou, Nikos, Jana Gutwein, Ole Ammerpohl, et al. "CLL Subsets with Distinct Stereotyped B Cell Receptors Have Distinct Epigenetic Make-up, Even Beyond IGHV Gene Mutational Status: DNA Methylation Profiling of IGHV-Unmutated CLL Stereotyped Subsets #6 and #8." Blood 120, no. 21 (2012): 3869. http://dx.doi.org/10.1182/blood.v120.21.3869.3869.

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Abstract Abstract 3869 In CLL, subsets of patients with stereotyped B cell receptors (BcRs) account for one-third of the cohort. Increasing evidence suggests that cases assigned to the same subset can share similar biological and clinical features independently of IGHV gene mutational status, at least for selected major subsets. Consequently, the study of BcR stereotypy has important implications for refining patient stratification with the ultimate aim of implementing targeted therapy and, eventually, improving outcome. CLL stereotyped subsets #6 (IGHV1–69/IGKV3–20) and #8 (IGHV4–39/IGKV1(D)-

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Jin, Yuwei, Wenbo Xu, Zhongwen Hu, Haitao Jia, Xin Luo, and Donghang Shao. "GSCA-UNet: Towards Automatic Shadow Detection in Urban Aerial Imagery with Global-Spatial-Context Attention Module." Remote Sensing 12, no. 17 (2020): 2864. http://dx.doi.org/10.3390/rs12172864.

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As an inevitable phenomenon in most optical remote-sensing images, the effect of shadows is prominent in urban scenes. Shadow detection is critical for exploiting shadows and recovering the distorted information. Unfortunately, in general, automatic shadow detection methods for urban aerial images cannot achieve satisfactory performance due to the limitation of feature patterns and the lack of consideration of non-local contextual information. To address this challenging problem, the global-spatial-context-attention (GSCA) module was developed to self-adaptively aggregate all global contextual

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Manno, Birgit, Thomas Oellerich, Tim Schnyder, et al. "The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner." European Journal of Immunology 46, no. 11 (2016): 2520–30. http://dx.doi.org/10.1002/eji.201646431.

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12

Scotti, Adalgisa, Stefano Milia, Vanesa Silvani, et al. "Sustainable Recovery of Secondary and Critical Raw Materials from Classified Mining Residues Using Mycorrhizal-Assisted Phytoextraction." Metals 11, no. 8 (2021): 1163. http://dx.doi.org/10.3390/met11081163.

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In this work, mycorrhizal-assisted phytoextraction (MAP, Helianthus annuus–arbuscular mycorrhizal fungus Rhizophagus intraradices–Zn-volcanic ashes) was applied for the recovery of secondary and critical raw materials (SRMs and CRMs, respectively) from Joda West (Odisha, India) mine residues, within a novel multidisciplinary management strategy. Mine residues were preliminarily characterized by using advanced analytical techniques, and subsequently mapped, classified and selected using multispectral satellite Sentinel-2A images and cluster analysis. Selected mine residues were treated by MAP a

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Yu, Chunfang, Jizhe Zhou, and Qin Li. "Multi-Supervised Encoder-Decoder for Image Forgery Localization." Electronics 10, no. 18 (2021): 2255. http://dx.doi.org/10.3390/electronics10182255.

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Image manipulation localization is one of the most challenging tasks because it pays more attention to tampering artifacts than to image content, which suggests that richer features need to be learned. Unlike many existing solutions, we employ a semantic segmentation network, named Multi-Supervised Encoder–Decoder (MSED), for the detection and localization of forgery images with arbitrary sizes and multiple types of manipulations without extra pre-training. In the basic encoder–decoder framework, the former encodes multi-scale contextual information by atrous convolution at multiple rates, whi

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Fontan, Lorena, Rebecca Goldstein, Gabriella Casalena, et al. "RNA Interference Screen Implicates TNFAIP3 and FOXO1 in MALT1 Inhibition Resistance." Blood 128, no. 22 (2016): 837. http://dx.doi.org/10.1182/blood.v128.22.837.837.

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Abstract Recent studies have identified small molecule inhibitors of the paracaspase activity of MALT1, a protease and scaffolding protein involved in the B-cell receptor (BCR) signaling pathway, that are effective killing lymphomas in vitro and in vivo in xenograft models of Activated B-cell like Diffuse Large B-cell Lymphoma (ABC-DLBCL). ABC-DLBCL is characterized by constitutive NF-κB activity. This activation has been attributed to mutations in various protein components of the B-cell receptor (BCR) as well as Toll-like receptor (TLR) pathways. However, not all ABC-DLBCL cell lines and pri

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15

Ramirez, Cody, Felix Frenkel, Olga Plotnikova, et al. "Identification of predicted neoantigen vaccine candidates in follicular lymphoma patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): 8054. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8054.

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8054 Background: Follicular lymphoma (FL) is incurable with conventional therapies and poorly responsive to immune checkpoint blockade. There is a need for new therapies without long-term complications of chemotherapy and with curative potential. We hypothesize that FL contains tumor-specific mutant antigens (TSMAs) that can be targeted by the immune system by vaccination. Recent reports have highlighted the potential for unique immunoglobulin peptides to elicit immune response in lymphomas. We utilized whole exome sequencing (WES) and RNA sequencing (RNA-Seq) of FL patient samples to infer HL

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16

Wolf, Diana, Patricia Domínguez-Cuevas, Richard A. Daniel, and Thorsten Mascher. "Cell Envelope Stress Response in Cell Wall-Deficient L-Forms of Bacillus subtilis." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5907–15. http://dx.doi.org/10.1128/aac.00770-12.

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ABSTRACTL-forms are cell wall-deficient bacteria that can grow and proliferate in osmotically stabilizing media. Recently, a strain of the Gram-positive model bacteriumBacillus subtiliswas constructed that allowed controlled switching between rod-shaped wild-type cells and corresponding L-forms. Both states can be stably maintained under suitable culture conditions. Because of the absence of a cell wall, L-forms are known to be insensitive to β-lactam antibiotics, but reports on the susceptibility of L-forms to other antibiotics that interfere with membrane-anchored steps of cell wall biosynth

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17

Khorashad, Jamshid Sorouri, Clinton C. Mason, Ira L. Kraft, et al. "An Unbiased shRNA Library Screen Identifies Nucleocytoplasmic Transport As a Potential Target For Treatment Of Chronic Myeloid Leukemia." Blood 122, no. 21 (2013): 2707. http://dx.doi.org/10.1182/blood.v122.21.2707.2707.

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Abstract Introduction BCR-ABL1 kinase domain mutations are detected in 30-60% of patients who develop resistance to tyrosine kinase inhibitors (TKIs) such as imatinib. However, the underlying mechanism(s) of resistance in the remaining patients are not known. To identify BCR-ABL1-independent mechanisms of resistance to TKIs, we used K562 cells that were adapted for long-term growth in 1 µM imatinib (K562-R). These cells lack BCR-ABL1 kinase domain mutations and survive despite continued suppression of BCR-ABL1 kinase activity. To screen for novel genes associated with BCR-ABL1-independent resi

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18

Ruminy, Philippe, Nimrod Buchbinder, Thomas Larson, et al. "Highly Multiplexed Targeted Sequencing of Recurrent Fusion Genes in Acute Leukemia." Blood 124, no. 21 (2014): 2335. http://dx.doi.org/10.1182/blood.v124.21.2335.2335.

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Abstract In acute leukemia, recurrent chromosomal translocations which result in the fusion of two genes are frequent. Some of these markers have a well established prognostic and therapeutic impact and are routinely screened at diagnosis by cytogenetics and RT-PCR. Yet, due to the limitations of these methods, only a few among the dozens of known rearrangements are systematically tested. Many abnormalities which could provide important clinical information thus remain ignored, mainly due to the impossibility of performing a cost effective multi-targeted screening. To overcome this obstacle, w

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19

Pillay, Nalishia, Martin Horan, Sze Yee Chai, Tony Badrick, Susan Branford, and Bruce Bennetts. "Developing a quantitative external quality assurance (EQA) module to monitor BCR-ABL1 levels in chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL) using the international scale (IS) to determine a patient's molecular response." Pathology 50 (February 2018): S100—S101. http://dx.doi.org/10.1016/j.pathol.2017.12.281.

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20

Enciso, Jennifer, Luis Mendoza, Elena R. Álvarez-Buylla, and Rosana Pelayo. "Dynamical modeling predicts an inflammation-inducible CXCR7+ B cell precursor with potential implications in lymphoid blockage pathologies." PeerJ 8 (September 29, 2020): e9902. http://dx.doi.org/10.7717/peerj.9902.

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Background The blockage at the early B lymphoid cell development pathway within the bone marrow is tightly associated with hematopoietic and immune diseases, where the disruption of basal regulatory networks prevents the continuous replenishment of functional B cells. Dynamic computational models may be instrumental for the comprehensive understanding of mechanisms underlying complex differentiation processes and provide novel prediction/intervention platforms to reinvigorate the system. Methods By reconstructing a three-module regulatory network including genetic transcription, intracellular

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Vensko, Steven, Benjamin Vincent, and Dante Bortone. "485 RAFT: A framework to support rapid and reproducible immuno-oncology analyses." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A521. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0485.

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BackgroundAnalysis reproducibility and transparency are pillars of robust and trustworthy scientific results. The dependability of these results is crucial in clinical settings where they may guide high-impact decisions affecting patient health. Independent reproduction of computational results has been problematic and can be a burden on the individuals attempting to reproduce the results. Reproduction complications may arise from: 1) insufficiently described parameters, 2) vague methods, or 3) secret scripts required to generate final outputs, among others. Here we introduce RAFT (Reproducibl

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22

Cochrane, Tara, Tatiana Chagorova, Tadeusz Robak, et al. "Venetoclax Improves Quality of Life for Patients with Elapsed/Refractory Chronic Lymphocytic Leukemia." Blood 132, Supplement 1 (2018): 4858. http://dx.doi.org/10.1182/blood-2018-99-117127.

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Abstract INTRODUCTION: Patients with chronic lymphocytic leukemia (CLL) have significantly decreased health related quality of life (HRQoL), particularly related to severe and progressive fatigue. Side effects of chemotherapies and the emotional burden of living with an often poor prognosis disease also negatively impact patient HRQoL. Venetoclax, an oral agent that targets the anti-apoptotic protein BCL2, has demonstrated high rates of deep and durable response in patients with relapsed/refractory (R/R) CLL, including those with 17p deletions, and has been shown to facilitate clinically relev

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Shojaee, Seyedmehdi, Maike Buchner, Srividya Swaminathan, et al. "Negative Feedback Signaling Enables Leukemic Transformation by Oncogenic Tyrosine Kinases." Blood 120, no. 21 (2012): 1352. http://dx.doi.org/10.1182/blood.v120.21.1352.1352.

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Abstract Abstract 1352 Background: Oncogenic tyrosine kinases drive malignant transformation in large subsets of hematological malignancies (e.g. BCR-ABL1, FLT3ITD) and are often associated with poor clinical outcome. Current efforts to improve therapeutic options for the treatment of tyrosine kinase-driven (TKD-) leukemia are almost entirely focused on the development of more potent tyrosine kinase inhibitors (TKI) with the goal to reduce oncogenic signaling below a minimum threshold that is required for the survival of TKD-tumor cells. Here we report the surprising finding that hyperactivati

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Milella, Michele, Maria Rosaria Ricciardi, Chiara Gregorj, et al. "Molecular and Functional Effects of the Novel MEK Inhibitor PD0325901 in Preclinical Models of Human Leukemias." Blood 108, no. 11 (2006): 254. http://dx.doi.org/10.1182/blood.v108.11.254.254.

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Abstract The Raf/MEK/ERK signaling module plays a pivotal role in the regulation of cell proliferation, survival, and differentiation. Our group, among others, has recently demonstrated that this pathway is frequently dysregulated in hematological malignancies and may constitute an attractive therapeutic target, particularly in AML. Here we investigated the effects of PD0325901, a novel MEK inhibitor, on phospho-protein expression, gene expression profiles, cell proliferation, and apoptosis in cell line models of AML, ALL, multiple myeloma (MM), ex vivo-cultured primary AML blasts, and oncogen

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Hjorth-Hansen, Henrik, Satu Mustjoki, Ulla Olsson-Strömberg, et al. "Health-Related Quality of Life Outcomes in Newly Diagnosed Chronic Myeloid Leukemia Patients Treated with Dasatinib and Low Dose Pegylated Interferon." Blood 132, Supplement 1 (2018): 4260. http://dx.doi.org/10.1182/blood-2018-99-111714.

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Abstract Background: Tyrosine kinase inhibitors (TKI) have revolutionized CML treatment but only a minority of patients are candidates to discontinue their TKI treatment, i.e. achieve treatment-free remission (TFR). Therefore, for the majority of patients TKI treatments are lifelong and it becomes critical to understand impact of therapy on patients' health-related quality of life (HRQoL).To obtain a maximal response for TFR, second generation TKIs like Dasatinib (DAS) induce deeper and faster responses than imatinib,and combination with pegylated forms of interferon-α2 have shown promising ef

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Tornatore, Laura, Gary Acton, Nigel Adams та ін. "Cancer-Selective Targeting of the NF-κB Survival Pathway in Multiple Myeloma with the GADD45β/MKK7 Inhibitor, DTP3". Blood 126, № 23 (2015): 868. http://dx.doi.org/10.1182/blood.v126.23.868.868.

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Abstract The NF-κB transcription factor pathway is aberrantly activated in multiple myeloma (MM) and many other cancers, where it promotes malignancy by upregulating survival genes, thus providing a compelling rationale for therapeutically targeting this pathway in MM. However, despite aggressive efforts to develop a specific NF-κB or IκB kinase (IKK)β inhibitor, no such inhibitor has been approved, due to the preclusive toxicities associated with the general suppression of NF-κB. As a key pathogenetic activity of NF-κB in MM is to block apoptosis through the induction of target genes, an attr

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Revilla-Guarinos, Ainhoa, Qian Zhang, Christoph Loderer, et al. "ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins." Applied and Environmental Microbiology 86, no. 14 (2020). http://dx.doi.org/10.1128/aem.00818-20.

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ABSTRACT Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an “orphan” ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was tested for sensitivity against a collection of peptides derived from bacteria, fungi, insects, and humans. Our results show that the transporter specifically conferred resistance against insect-derived cysteine-stabilized αβ defensins, and it was therefore renamed DerAB for defensin re

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Sun, Kexin, Yuelan Xin, Yide Ma, Meng Lou, Yunliang Qi, and Jie Zhu. "ASU-Net: U-shape adaptive scale network for mass segmentation in mammograms." Journal of Intelligent & Fuzzy Systems, July 15, 2021, 1–16. http://dx.doi.org/10.3233/jifs-210393.

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U-Net is a commonly used deep learning model for mammogram segmentation. Despite outstanding overall performance in segmenting, U-Net still faces from two aspects of challenges: (1) the skip-connections in U-Net have limitations, which may not be able to effectively extract multi-scale features for breast masses with diverse shapes and sizes. (2) U-Net only merges low-level spatial information and high-level semantic information through concatenating, which neglects interdependencies between channels. To address these two problems, we propose the U-shape adaptive scale network (ASU-Net), which

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Engels, Niklas, Lars M. König, Wiebke Schulze, et al. "The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module." Nature Communications 5, no. 1 (2014). http://dx.doi.org/10.1038/ncomms6456.

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Campelo, Ana Belén, María Jesús López-González, Susana Escobedo, et al. "Mutations Selected After Exposure to Bacteriocin Lcn972 Activate a Bce-Like Bacitracin Resistance Module in Lactococcus lactis." Frontiers in Microbiology 11 (August 13, 2020). http://dx.doi.org/10.3389/fmicb.2020.01805.

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31

Zouhir, Samira, Wiem Abidi, Meryem Caleechurn, and Petya Violinova Krasteva. "Structure and Multitasking of the c-di-GMP-Sensing Cellulose Secretion Regulator BcsE." mBio 11, no. 4 (2020). http://dx.doi.org/10.1128/mbio.01303-20.

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ABSTRACT Most bacteria respond to surfaces by biogenesis of intracellular c-di-GMP, which inhibits motility and induces secretion of biofilm-promoting adherence factors. Bacterial cellulose is a widespread biofilm component whose secretion in Gram-negative species requires an inner membrane, c-di-GMP-dependent synthase tandem (BcsAB), an outer membrane porin (BcsC), and various accessory subunits that regulate synthase assembly and function as well as the exopolysaccharide’s chemical composition and mechanical properties. We recently showed that in Escherichia coli, most Bcs proteins form a me

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