Academic literature on the topic 'Mosapride'

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Journal articles on the topic "Mosapride"

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&NA;. "Mosapride." Reactions Weekly &NA;, no. 1414 (2012): 38. http://dx.doi.org/10.2165/00128415-201214140-00128.

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Curran, Monique P., and Dean M. Robinson. "Mosapride." Drugs 68, no. 7 (2008): 981–91. http://dx.doi.org/10.2165/00003495-200868070-00007.

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Wu, Xiao, Cuihong Zheng, Xiaohu Xu, et al. "Electroacupuncture for Functional Constipation: A Multicenter, Randomized, Control Trial." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/1428943.

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Background and Aim. To investigate the efficacy and safety of electroacupuncture (EA) with different current intensities for functional constipation (FC) and to assess whether the effects of EA with different current intensities are superior to the mosapride.Methods. Patients with FC were randomly divided into low current intensity group (LCI), high current intensity group (HCI), and mosapride group (MC). The primary outcome was three or more spontaneous bowel movements (SBMs) per week and an increase of one or more SBMs from baseline during at least 3 of the 4 weeks.Results. The primary outco
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Yoshida, N., S. Kato, and T. Ito. "Mosapride citrate." Drugs of the Future 18, no. 6 (1993): 513. http://dx.doi.org/10.1358/dof.1993.018.06.209477.

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Choi, Hyun Seok, Eui Joong Kim, Min Seob Kim, et al. "Effect of Combination Therapy of Oral Famotidine with Mosapride on Intragastric pH and Gastric Emptying in Rats." Korean Journal of Helicobacter and Upper Gastrointestinal Research 21, no. 3 (2021): 220–25. http://dx.doi.org/10.7704/kjhugr.2021.0013.

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Background/Aims: Studies in healthy humans have reported that the addition of mosapride to acid suppressants resulted in higher intragastric pH than acid suppressant administration alone. We investigated the effect of the addition of mosapride to famotidine on the intragastric pH and gastric emptying rate (GER) in rats.Materials and Methods: Sixty male Wistar rats were used in this study. Experimental groups were divided into control, famotidine-only, mosapride-only, and famotidine with mosapride (combination). The first experiment was performed in non-stressed rats. Mosapride was administered
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Nishizawa, Toshihiro, Kiyoto Mori, Shuntaro Yoshida, Hirotoshi Ebinuma, Osamu Toyoshima, and Hidekazu Suzuki. "Additional Mosapride to Proton Pump Inhibitor for Gastroesophageal Reflux Disease: A Meta-Analysis." Journal of Clinical Medicine 9, no. 9 (2020): 2705. http://dx.doi.org/10.3390/jcm9092705.

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Background and Aim: In gastroesophageal reflux disease (GERD), the additive effect of mosapride to a proton pump inhibitor (PPI) is still controversial. This meta-analysis integrated randomized controlled trials (RCTs) in which mosapride combined with a PPI was compared with a PPI alone in GERD treatment. Methods: RCTs were systematically searched with the PubMed, Cochrane library, Web of Science, and the Igaku-Chuo-Zasshi database. We combined the data from the RCTs with a random effects model, calculated the standardized mean difference (SMD) and pooled the risk difference (RD) with 95% conf
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Wu, Tong, Guanhua Wang, Caihong Shi, et al. "Development and evaluation of orally disintegrating tablets containing the mosapride resin complex." Acta Pharmaceutica 68, no. 2 (2018): 159–70. http://dx.doi.org/10.2478/acph-2018-0017.

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Abstract The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compressio
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Kawahara, Isao, Hiroki Kuniyasu, Hiroko Matsuyoshi, et al. "Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 6 (2012): G588—G597. http://dx.doi.org/10.1152/ajpgi.00284.2011.

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It was recently reported that activation of enteric neural 5-HT4 receptors (SR4) promotes reconstruction of enteric neural circuit injury in distal gut of guinea pigs and that this reconstruction involves neural stem cells. We aimed to explore a novel approach using a selective serotonin reuptake inhibitor (SSRI), which increases endogenous 5-HT, to repair enteric nerve fiber injury in the rat distal gut. Enteric nerve fiber injury was performed by rectal transection and subsequent end-to-end one-layer anastomosis. The SSRI fluvoxamine maleate (100 μmol/l) was applied locally at the anastomoti
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Lian, Xiaofang, Yiran Li, Limin Zuo, et al. "Comparison and Determination of the Content of Mosapride Citrate by Different qNMR Methods." International Journal of Molecular Sciences 25, no. 19 (2024): 10442. http://dx.doi.org/10.3390/ijms251910442.

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As a salt-type compound, mosapride citrate’s metabolism and side effects are correlated with its salt-forming ratio. Several techniques were developed in this work to compare various quantitative nuclear magnetic resonance (qNMR) methodologies and to quantitatively examine the content of raw materials. Among the qNMR techniques, methods for 1H NMR and 19F NMR were developed. Appropriate solvents were chosen, and temperature, number of scans, acquisition time, and relaxation delay parameter settings were optimized. Maleic acid was chosen as the internal standard in 1H NMR, and the respective ch
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Zhang, Yu-Jing, and Shen-Ping Wu. "Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery." World Journal of Clinical Cases 12, no. 13 (2024): 2194–200. http://dx.doi.org/10.12998/wjcc.v12.i13.2194.

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BACKGROUND Gastroesophageal reflux disease (GERD) is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic leakage. Wendan Decoction (WDD) is a traditional Chinese herbal formula used to treat various gastrointestinal disorders, such as gastritis, functional dyspepsia, and irritable bowel syndrome. Mosapride, a prokinetic agent, functions as a selective 5-hydroxytryptamine 4 agonist, enhancing gastrointestinal motility. AIM To evaluate the therapeutic effects of WDD combined with mosapride on GERD after
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Dissertations / Theses on the topic "Mosapride"

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Wen-HanChen and 陳玟翰. "Mosapride as a hepatic CYP3A probe in rats: application to rilpivirine pharmacokinetics." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/9vt35v.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>101<br>Introduction: Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type-1 (HIV-1). It can be used in the treatment of naïve HIV-1 infected patients. The elimination of rilpivirine in man is mainly by metabolism. The major enzymes responsible for the metabolism of rilpivirine are CYP3A isozymes, thus drugs that induce or inhibit the CYP3A would change the clearance of rilpivirine. CYP3A is one of the most important CYP450 subfamilies expressed in the liver and small intestine with great variation. The use
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Chien-LungTu and 杜建龍. "Mosapride as a hepatic CYP3A probe in rats: application to rivaroxaban pharmacokinetics." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/v86m9j.

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碩士<br>國立成功大學<br>藥理學研究所<br>101<br>Introduction Rivaroxaban, an oral, direct, specific inhibitor of factor Xa, is indicated for the prophylaxis of deep vein thrombosis. About two-thirds of the administered dose of rivaroxaban undergoes metabolic degradation. CYP3A isozymes, one of the most important and abundant CYP450 subfamilies in the liver, are the major enzymes that responsible for the metabolism of rivaroxaban, thus drugs that induce or inhibit the CYP3A would change the clearance of rivaroxaban. The use of selected drugs as in vivio CYP3A probes in drug therapy is of great importance.
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Yin-YinTung and 董茵茵. "Assessing Aging-Effect on CYP3A Activity in Rats with Probe Substrate Mosapride." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/ad33z7.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>104<br>Age of subjects can play a key role in variability in pharmacokinetics and thus efficacy and safety of drugs. CYP3A is one of the most important CYP450 subfamilies with great variation. The use of CYP3A phenotyping probes in drug therapy is of great importance. In this study, the age-related changes in the pharmacokinetics of a putative CYP3A phenotyping probe mosapride and a CYP3A substrate rilpivirine in rats were investigated. The disposition kinetics of mosapride and rilpivirine in rats displayed two-compartmental characteristics. Aging significantly
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Li-ChiYang and 楊禮綺. "Feasibility of Mosapride to predict enzyme-based drug-drug interactions in rats." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/42512722099225907650.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>100<br>Introduction CYP3A is one of the most important and most abundant subfamily expressed in the liver and small intestine. The use of selected drugs as “probes” to assess in vivo CYP activity has been the subject of intense interest for over a decade. Among many CYP3A probes, midazolam is the most accepted CYP3A probe used in human, but it’s use is limited. Mosapride, a new prokinetic agent, undergoes N-dealkylation metabolism to form des-4-fluoro-benzyl metabolite (M-1) mediated by CYP3A enzymes.After intravenous and oral administration of mosapride, the he
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Pei-HsuanJen and 任沛瑄. "Mosapride as a hepatic CYP3A probe in rats:compared with the reference probe midazolam." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/58093888886482002363.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>98<br>Introduction Cytochrome P450 3A is one of the most important CYP450 subfamilies because of its large number of xenobiotics and endogenous substrates. Considerable interindividual variability in the expression and activity of CYP3A was proved to be responsible for variability in drug response. The use of selected drugs as “probes” to assess in vivo CYP activity has been the subject of intense interest for over a decade.This approach is suggested by numerous organizations, including the US Food and Drug Administration, European Federation of Pharmaceutical Scienc
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Chang, Ya-Wen, and 張雅雯. "Feasibility of mosapride as an in vivo probe of CYP3A activity in rats." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/01350560592501498026.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>96<br>Introduction Cytochrome P450 3A is one of the most important CYP450 subfamilies because of its large number of xenobiotics and endogeneous substrates. Interindividual variability in the expression and activity of CYP3A is considerable, and may be responsible for variability in drug response. By administration of probe drug, it can permit measurement of real-time enzyme activity and provides more clinically relevant information. Mosapride, a new prokinetic agent, undergoes N-dealkylation metabolism to form des-4-fluoro-benzyl metabolite (M-1). According to the r
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Wei, Ching-yun, and 魏敬云. "Limited sampling strategy to predict AUC of CYP3A phenotyping probe mosapride in rats." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/21124511543327888281.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>97<br>Introduction Cytochrome P450 3A (CYP3A) is an important subfamily of drug- metabolizing enzymes. In humans, it is responsible for metabolizing numerous drugs across several therapeutic classes. Interindividual variability in the expression and activity of CYP3A is considerable, and may be responsible for variability in drug response. The use of probe substrates is a widely accepted method for evaluating the activity of cytochrome P450 (CYP) enzymes in individuals. Mosapride, a new prokinetic agent, was evaluated as an in vivo probe for measuring hepatic CYP3A a
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Book chapters on the topic "Mosapride"

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Ferrão, Bianca Magalhães, and Ethel Zimberg Chehter. "The importance of serotonin in the treatment of functional dyspepsia." In CIÊNCIAS DA SAÚDE E SUAS DESCOBERTAS CIENTÍFICAS. Seven Editora, 2023. http://dx.doi.org/10.56238/ciesaudesv1-006.

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Introduction: Functional dyspepsia (FD) is a gastrointestinal disorder of multifactorial etiology. Although present in about 20% of the world population, there is no satisfactory pharmacological treatment for these patients yet. Considering the fundamental role of serotonin in the pathogenesis of functional gastrointestinal disorders, the objective of this study was to review the literature related to the use of serotonergic drugs in the treatment of FD and assess their effectiveness. Method: We conducted a horizontal review in the PubMed® database on the treatment of FD and serotonin. Article
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Conference papers on the topic "Mosapride"

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Guo, Wanwei. "IDDF2023-ABS-0142 Observation of the clinical therapeutic effect of mosapride citrate dispersible tablets in combination with flupentixol and melitracen tablets in the treatment of functional dyspepsia in the elderly." In Abstracts of the International Digestive Disease Forum (IDDF), Hong Kong, 10–11 June 2023. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2023. http://dx.doi.org/10.1136/gutjnl-2023-iddf.81.

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Reports on the topic "Mosapride"

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Zheng, You-you, Ning Liang, Long-kun Liu, et al. Effectiveness and Safety of Chinese Patent Medicine for Functional Constipation: A Systematic Review and Network-Meta Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0049.

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Review question / Objective: To evaluate the effectiveness and safety of Chinese patent medicine in treatment of functional constipation by using the Network Meta-Analysis. 1. Types of participants: participants diagnosed as functional constipation according to Rome III, Rome IV or other published criteria or guidelines. No limitation on types of FC, age, sex, and nation. Children and pregnant women were excluded. Participants who had other constipation-related diseases including irritable bowel syndrome, functional defecation disorders and opioid-induced constipation were excluded. 2 Types of
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Lu, Ai Yang Zi, Hui Gao, Lei Hao, Xi Wang, Cheng Shi, and Yixin Zhang. Systematic evaluation and Meta-analysis of Three Seeds Decoction in the treatment of functional dyspepsia compared with cisapride and mosapride. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.6.0084.

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