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MALLADI, RAJESWARI. "APPLYING MULTIPLE QUERY OPTIMIZATION IN MOBILE DATABASES." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin996673274.
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Brondello, Jean-Marc. "Les map kinase phosphatases (mkp)-1, mkp-2 et mkp-3 : regulation et fonctions dans les fibroblastes." Nice, 1997. http://www.theses.fr/1997NICE5207.
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La principale caracteristique de la phosphorylation des proteines cellulaires est sa reversibilite. Dans la cellule, il existe une balance entre la phosphorylation (assuree par des kinases) et la dephosphorylation (assuree par des phosphatases) des proteines. Une modification de cette balance est a l'origine d'une grande partie des mecanismes permettant la transmission des signaux extracellulaires vers le noyau. Les phosphatases sont generalement divisees en trois grandes familles : les serine/threonine phosphatases, les tyrosine phosphatases et les phosphatases a double specificite. Map kinase phosphatase-1 (mkp-1), mkp-2 et mkp-3 sont tous trois membres de la nouvelle famille des phosphatases a double specificite (dsp) qui arborent la sequence consensus : (i/v)hcxagxxr(s/t)g. Ces mkp ont la propriete de dephosphoryler in vitro comme in vivo un substrat archetype, la p42/p44mapk. Afin de determiner l'impact de ces phosphatases sur la regulation des mapk ainsi que leur role dans la proliferation, nous avons entrepris leur etude dans le systeme bien defini des fibroblastes d'hamster chinois, les ccl39. Dans un premier temps, nous avons demontre (i) qu'une forme ectopique de mkp-1 (1-) se localise dans le noyau de cellules quiescentes ou stimulees. (ii) que cette forme surexprimee est capable de bloquer des activites nucleaires de la p42/p44mapk, la transcription de genes de la transition g1/s et enfin la replication de l'adn des cellules transfectees. Dans un second temps, nous avons entrepris la production d'anticorps polyclonaux diriges contre mkp-1 et mkp-2. Nous avons ainsi caracterise les voies de signalisation conduisant a l'expression de mkp-1 et de mkp-2 dans les cellules ccl39. La voie ras/mapk est suffisante pour
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Zhang, Jiaqi. "Accelerating and Predicting Map Projections with CUDA and MLP." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523394255002174.
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Sloss, Callum. "Control of subcellular distribution of the MAP kinase phosphatase, MKP-2." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288715.
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Lawan, Ahmed. "The role of map kinase phosphatase-2 (MKP-2) in cardiac function." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14506.
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Dupuy, Jonathan. "Photorealistic Surface Rendering with Microfacet Theory." Thèse, Lyon 1, 2015. http://hdl.handle.net/1866/13711.
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La synthèse d'images dites photoréalistes nécessite d'évaluer numériquement la manière dont la lumière et la matière interagissent physiquement, ce qui, malgré la puissance de calcul impressionnante dont nous bénéficions aujourd'hui et qui ne cesse d'augmenter, est encore bien loin de devenir une tâche triviale pour nos ordinateurs. Ceci est dû en majeure partie à la manière dont nous représentons les objets: afin de reproduire les interactions subtiles qui mènent à la perception du détail, il est nécessaire de modéliser des quantités phénoménales de géométries. Au moment du rendu, cette complexité conduit inexorablement à de lourdes requêtes d'entrées-sorties, qui, couplées à des évaluations d'opérateurs de filtrage complexes, rendent les temps de calcul nécessaires à produire des images sans défaut totalement déraisonnables. Afin de pallier ces limitations sous les contraintes actuelles, il est nécessaire de dériver une représentation multiéchelle de la matière.
Dans cette thèse, nous construisons une telle représentation pour la matière dont l'interface correspond à une surface perturbée, une configuration qui se construit généralement via des cartes d'élévations en infographie. Nous dérivons notre représentation dans le contexte de la théorie des microfacettes (conçue à l'origine pour modéliser la réflectance de surfaces rugueuses), que nous présentons d'abord, puis augmentons en deux temps. Dans un premier temps, nous rendons la théorie applicable à travers plusieurs échelles d'observation en la généralisant aux statistiques de microfacettes décentrées. Dans l'autre, nous dérivons une procédure d'inversion capable de reconstruire les statistiques de microfacettes à partir de réponses de réflexion d'un matériau arbitraire dans les configurations de rétroréflexion. Nous montrons comment cette théorie augmentée peut être exploitée afin de dériver un opérateur général et efficace de rééchantillonnage approximatif de cartes d'élévations qui (a) préserve l'anisotropie du transport de la lumière pour n'importe quelle résolution, (b) peut être appliqué en amont du rendu et stocké dans des MIP maps afin de diminuer drastiquement le nombre de requêtes d'entrées-sorties, et (c) simplifie de manière considérable les opérations de filtrage par pixel, le tout conduisant à des temps de rendu plus courts. Afin de valider et démontrer l'efficacité de notre opérateur, nous synthétisons des images photoréalistes anticrenelées et les comparons à des images de référence. De plus, nous fournissons une implantation C++ complète tout au long de la dissertation afin de faciliter la reproduction des résultats obtenus. Nous concluons avec une discussion portant sur les limitations de notre approche, ainsi que sur les verrous restant à lever afin de dériver une représentation multiéchelle de la matière encore plus générale.<br>Photorealistic rendering involves the numeric resolution of physically accurate light/matter interactions which, despite the tremendous and continuously increasing computational power that we now have at our disposal, is nowhere from becoming a quick and simple task for our computers. This is mainly due to the way that we represent objects: in order to reproduce the subtle interactions that create detail, tremendous amounts of geometry need to be queried. Hence, at render time, this complexity leads to heavy input/output operations which, combined with numerically complex filtering operators, require unreasonable amounts of computation times to guarantee artifact-free images. In order to alleviate such issues with today's constraints, a multiscale representation for matter must be derived.
In this thesis, we derive such a representation for matter whose interface can be modelled as a displaced surface, a configuration that is typically simulated with displacement texture mapping in computer graphics. Our representation is derived within the realm of microfacet theory (a framework originally designed to model reflection of rough surfaces), which we review and augment in two respects. First, we render the theory applicable across multiple scales by extending it to support noncentral microfacet statistics. Second, we derive an inversion procedure that retrieves microfacet statistics from backscattering reflection evaluations. We show how this augmented framework may be applied to derive a general and efficient (although approximate) down-sampling operator for displacement texture maps that (a) preserves the anisotropy exhibited by light transport for any resolution, (b) can be applied prior to rendering and stored into MIP texture maps to drastically reduce the number of input/output operations, and (c) considerably simplifies per-pixel filtering operations, resulting overall in shorter rendering times. In order to validate and demonstrate the effectiveness of our operator, we render antialiased photorealistic images against ground truth. In addition, we provide C++ implementations all along the dissertation to facilitate the reproduction of the presented results. We conclude with a discussion on limitations of our approach, and avenues for a more general multiscale representation for matter.
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Ritter, Linda Marie. "Promoter Studies of The Human MIP-1(alpha) Gene and Characterization of Two Novel trans-Acting Factors: MNP-1 and MNP-2 /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351058656.
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Penha, Tatiane Aranha da [UNESP]. "Expressão das quimiocinas MIP-1α e MCP-1 em relação à carga parasitária em cães com leishmaniose visceral". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/94617.
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penha_ta_me_jabo.pdf: 999907 bytes, checksum: 65a051d69be1b9f6360131e9bb8dadf6 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A Leishmaniose Visceral (LV) é uma zoonose de distribuição mundial. No Brasil foi descrita em várias regiões, mas na região sudeste vem ocorrendo de forma significativa desde 1998, na região de Araçatuba, SP. O cão é o principal reservatório doméstico do protozoário Leishmania chagasi e a principal fonte de contaminação para o homem. A resposta imune do hospedeiro canino frente ao parasito é variável e por este fato, os cães apresentam sinais clínicos acentuados ou ausência destes. Os animais que apresentam maior carga parasitária e sinais clínicos mais severos são considerados susceptíveis à infecção pelo parasito. Este padrão está associado ao perfil de citocinas produzidas, ou seja, na predominância de citocinas Th1 são resistentes ou Th2 susceptíveis. No entanto existem muitas variações neste padrão de resposta, ou seja, muitos animais apresentam a produção de citocinas Th1 e Th2, sugerindo um desequilíbrio na proporção de citocinas pró e antiinflamatórias, que favorecem a multiplicação e sobrevivência dos parasitos. Este desequilíbrio tem influência direta sobre a ativação de macrófagos e sobre sua capacidade microbicida e de apresentação antigênica, levando a uma anergia de linfócitos T e a manutenção e cronicidade da infecção. As quimiocinas são citocinas com potente atividade quimiotática sobre leucócitos. Na LV existem estudos no homem e em modelos experimentais, mas no cão apenas um estudo avalia o seu papel no baço. Existe muita controvérsia sobre o seu verdadeiro papel na LV, pois descreve-se tanto a sua ação próinflamatória quanto a sua ação deletéria, que favorece o parasito. Portanto, o objetivo deste estudo foi avaliar o papel das quimiocinas MIP-1a e MCP-1 no baço e fígado de 30 cães...<br>Visceral Leishmaniasis (VL) is a zoonosis of worldwide distribution. In Brazil has been described in several regions, but has been occurring in the Southeast significantly since 1998 in Araçatuba, SP. The dog is the main domestic reservoir of Leishmania chagasi and the main source of contamination for humans. The canine host immune response against the parasite is variable. Dogs have severe intensity or absence of clinical symptoms. Animals that have a higher parasite load and clinical signs are considered more susceptible to infection by the parasite. This pattern is associated with the profile of cytokines produced, in the predominance of Th1 they are resistant or in the predominance of Th2 they are susceptible. However there are many variations on this response pattern, many animals have the production of Th1 and Th2 cytokines, suggesting an imbalance in the proportion of pro and anti-inflammatory cytokines, which favor the multiplication and survival of parasites. This imbalance has a direct influence on the activation of macrophages and their microbicidal activity and antigen presentation, leading to anergy of T lymphocytes and the maintenance and chronicity of infection. Chemokines are cytokines with potent chemotactic activity on leukocytes. In the VL are studies in humans and experimental models, but the dog only one study assessing its role in the spleen. There is much controversy over its true role in VL, because it describes both its pro-inflammatory action and its deleterious effects, which favors the parasite. Therefore, the aim of this study was to evaluate the role of chemokines MIP-1α and MCP-1 in the spleen and liver of 30 dogs naturally infected with Leishmania spp. and compare the findings with the parasite load of each organ. For this purpose, samples of liver and spleen were analyzed... (Complete abstract click electronic access below)
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Penha, Tatiane Aranha da. "Expressão das quimiocinas MIP-1α e MCP-1 em relação à carga parasitária em cães com leishmaniose visceral /". Jaboticabal : [s.n.], 2011. http://hdl.handle.net/11449/94617.
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Orientador: Rosemeri de Oliveira Vasconcelos<br>Coorientador: Valéria Marçal Felix de Lima<br>Banca: Ana Lúcia Abreu Silva<br>Banca: Hélio José Montassier<br>Resumo: A Leishmaniose Visceral (LV) é uma zoonose de distribuição mundial. No Brasil foi descrita em várias regiões, mas na região sudeste vem ocorrendo de forma significativa desde 1998, na região de Araçatuba, SP. O cão é o principal reservatório doméstico do protozoário Leishmania chagasi e a principal fonte de contaminação para o homem. A resposta imune do hospedeiro canino frente ao parasito é variável e por este fato, os cães apresentam sinais clínicos acentuados ou ausência destes. Os animais que apresentam maior carga parasitária e sinais clínicos mais severos são considerados susceptíveis à infecção pelo parasito. Este padrão está associado ao perfil de citocinas produzidas, ou seja, na predominância de citocinas Th1 são resistentes ou Th2 susceptíveis. No entanto existem muitas variações neste padrão de resposta, ou seja, muitos animais apresentam a produção de citocinas Th1 e Th2, sugerindo um desequilíbrio na proporção de citocinas pró e antiinflamatórias, que favorecem a multiplicação e sobrevivência dos parasitos. Este desequilíbrio tem influência direta sobre a ativação de macrófagos e sobre sua capacidade microbicida e de apresentação antigênica, levando a uma anergia de linfócitos T e a manutenção e cronicidade da infecção. As quimiocinas são citocinas com potente atividade quimiotática sobre leucócitos. Na LV existem estudos no homem e em modelos experimentais, mas no cão apenas um estudo avalia o seu papel no baço. Existe muita controvérsia sobre o seu verdadeiro papel na LV, pois descreve-se tanto a sua ação próinflamatória quanto a sua ação deletéria, que favorece o parasito. Portanto, o objetivo deste estudo foi avaliar o papel das quimiocinas MIP-1a e MCP-1 no baço e fígado de 30 cães... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Visceral Leishmaniasis (VL) is a zoonosis of worldwide distribution. In Brazil has been described in several regions, but has been occurring in the Southeast significantly since 1998 in Araçatuba, SP. The dog is the main domestic reservoir of Leishmania chagasi and the main source of contamination for humans. The canine host immune response against the parasite is variable. Dogs have severe intensity or absence of clinical symptoms. Animals that have a higher parasite load and clinical signs are considered more susceptible to infection by the parasite. This pattern is associated with the profile of cytokines produced, in the predominance of Th1 they are resistant or in the predominance of Th2 they are susceptible. However there are many variations on this response pattern, many animals have the production of Th1 and Th2 cytokines, suggesting an imbalance in the proportion of pro and anti-inflammatory cytokines, which favor the multiplication and survival of parasites. This imbalance has a direct influence on the activation of macrophages and their microbicidal activity and antigen presentation, leading to anergy of T lymphocytes and the maintenance and chronicity of infection. Chemokines are cytokines with potent chemotactic activity on leukocytes. In the VL are studies in humans and experimental models, but the dog only one study assessing its role in the spleen. There is much controversy over its true role in VL, because it describes both its pro-inflammatory action and its deleterious effects, which favors the parasite. Therefore, the aim of this study was to evaluate the role of chemokines MIP-1α and MCP-1 in the spleen and liver of 30 dogs naturally infected with Leishmania spp. and compare the findings with the parasite load of each organ. For this purpose, samples of liver and spleen were analyzed... (Complete abstract click electronic access below)<br>Mestre
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Hellberg, Caroline, and Josefine Sundberg. "MQ - Big fan of varumärken : En fallstudie om användandet av celebriteter i MQs marknadsföring." Thesis, Jönköping University, School of Education and Communication, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-7649.
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<p>Kändisreklam har vuxit och blivit en effektiv marknadsföringsmetod över hela världen. Syftet med denna uppsats är att undersöka varför klädesföretaget MQ väljer att använda sig av celebriteter i sin marknadsföring och detta undersöker vi genom en fallstudie. Vi valde att göra kvalitativa forskningsintervjuer för att få samla information och tillsammans med teorier inom ämnesområdet har vi kunnat uppfylla syftet. Respondenterna för intervjuerna var två personer från MQs marknadsavdelning. Det vi ville få svar på var varför MQ väljer att använda sig av kändisreklam, hur de väljer vilken celebritet de ska använda, vad de vill kommunicera genom sin användning av celebriteter och vilka risker det finns i att använda sig av kändisreklam.</p><p>Fallstudien visar att MQ valt att använda sig av celebriteter i sin marknadsföring på grund av uppmärksamhetsvärdet och trovärdigheten som skapas med hjälp av kändisreklam. Den visar även att MQ går igenom en lång process innan de väljer en celebritet och att det är mycket som måste stämma med en celebritet för att den ska bli vald. Till sist fick vi också svar på att MQ vill kommunicera att de säljer kläder av god kvalité för svenskar mellan 20-40 år och att de försöker på bästa sätt undvika de risker som finns i användandet av kändisreklam. Vår studie visar att den befintliga forskningen och teorin stämmer bra överens med informationen vi fick ifrån våra intervjuer med MQ. Resultatet i vår studie stärker också de påstående om att det är viktigt att celebriteten är trovärdig och det grundas i celebritetens utseende och expertis. Valet av celebritet måste också överensstämma med företagets varumärke och budskap.</p><p> </p>
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Nishitani, Kohei. "PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes." Kyoto University, 2010. http://hdl.handle.net/2433/120599.
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Barbour, Mark J. "The role of map kinase phosphatase 2 (MKP-2) in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25821.
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Experimental Autoimmune Encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), causing a demyelinating central nervous system (CNS) inflammation which resembles the main pathological features of MS. Mitogen-activated protein kinases (MAPKs), which are key components in the molecular response leading to MS/EAE pathogenesis, are regulated by MAPK phosphatases (MKPs), enzymes which dephosphorylate phosphotyrosine and phosphothreonine residues. It has previously been shown that MKP-2 modulates the inflammatory response during both acute lung injury and sepsis. Therefore in the present study we investigated the role of MKP-2 in the development of the neurological autoimmune disease, MS, using a murine EAE model. We first observed significantly increased expression of MKP-2 mRNA in the spinal cord of EAE mice compared with PBS controls. Subsequently, to understand the function of MKP-2 in vivo, we utilised MKP-2 deficient mice, inducing EAE in MKP-2 KO and WT littermates. Our data show that MKP-2 KO mice displayed significantly reduced EAE susceptibility, associated with diminished CNS inflammation and cellular infiltration, decreased expression of key cytokines and chemokines (IL-17, IFNγ, IL-6, IL-2 and CCL2), reduced frequency of CD4⁺ T cells, CD8⁺ T cells and B cells in spleen and dLN tissue as well as downregulated nitric oxide (NO) production in MKP-2 KO EAE mice. We further analysed the role of MKP-2 in two key immune cells involved in EAE pathogenesis. Upon LPS stimulation, MKP-2 deficient bone marrow-derived dendritic cells expressed less MHC-II while producing more IL-6, TNF-α and IL-10, whereas MKP-2 KO bone marrow-derived macrophages displayed a unique M1 and M2 mixed phenotype, with reduced NO production (M1) and increased CD206 expression (M2) but increased IL-6 and TNF-α, which are more associated with M1 responses. Therefore this report suggests that MKP-2 is essential to the pathogenic response of EAE, and that inhibition of MKP-2 expression or function may be a viable strategy in the treatment of autoimmune inflammatory diseases such as MS.
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Eger, Glenda. "Regulation and Function of MAP Kinases in PDGF Signaling." Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301057.
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Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. Aberrant activation of these pathways is frequently detected in cancer. Hence, the study of these processes is essential for identifying potential drug targets or diagnostic markers. In paper I, we identified Receptor Subfamily 4 Group A Member 1 NR4A1 to be regulated by PDGF via MAP kinases, clarifying the role of Extracellular signal–regulated kinases (Erk) 1/2, Erk5 and Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) in its regulation. NR4A1 was found to be important for the tumorigenic potential, measured as anchorage-independent growth, of glioblastoma cells. Since the cellular responses elicited by PDGF result from the balance between phosphorylation and dephosphorylation events, we investigated the role of the dual specificity phosphatases DUSP4/MKP-2 and DUSP6/MKP-3. In paper II, we describe the crucial role of Erk1/2 and p53 in the expression of DUSP4/MKP2. Moreover, we observed that DUSP4/MKP-2 downregulation decreases Erk5 activation and accelerates PDGFRβ internalization and downregulation resulting in a specific inhibition of Signal transducers and activators of transcription (Stat) 3, Src and protein kinase C (PKC), and partially of p38, Stat1/5 and Phoshoplipase Cγ (PLCγ). In paper III, we report that DUSP6/MKP-3 creates a negative cross-talk between Erk1/2 and Erk5 and an auto-inhibitory feedback loop on the PI3-kinase/Akt pathway. In paper IV, we identify a new regulative mechanism of the PDGF pathway. PDGF induces Erk5 expression and activation that modulates the PDGFRβ activity. After Erk5 downregulation, the receptor undergoes to a faster and stronger activation that results in a faster internalization and degradation. In conclusion, we present a mechanism through which the PDGF/MAP kinases support tumor growth, and elucidate different regulatory pathways involved in PDGF signaling.
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Fendi, Ranya. "MÄTNING AV ANDNINGSMUSKELSTYRKA." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24122.
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Grüb, Birgit. "Gründung von Universitätsverlagen am Beispiel der Universität Mannheim." Mannheim Mannheim Univ. Press, 2006. http://madoc.bib.uni-mannheim.de/mup/frontdoor.php?sourceo̲pus=2.
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Mikulicz-Radecki, Johannes von. "Die Rolle von Fertigungsmitarbeitern im strategischen Human-Resource-Management." Mannheim Univ. Press, 2006. http://madoc.bib.uni-mannheim.de/mup/frontdoor.php?sourceo̲pus=7.
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Grüb, Birgit. "Gründung von Universitätsverlagen am Beispiel der Universität Mannheim." Mannheim Mannheim Univ. Press, 2004. http://madoc.bib.uni-mannheim.de/mup/frontdoor.php?source_opus=2.
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Glöckner, Andreas. "Die Anwendung internationaler Rechnungslegungsstandards (IPSAS/IFRS) auf ausgewählte Bilanzierungsprobleme der doppischen kommunalen Rechnungslegung." Mannheim : Mannheim Univ. Press, 2007. http://madoc.bib.uni-mannheim.de/mup/volltexte/2007/9/.
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Größler, Andreas. "Struktur und Dynamik strategischer Fähigkeiten in der Produktion." Mannheim : Mannheim Univ. Press, 2007. http://madoc.bib.uni-mannheim.de/mup/volltexte/2007/14/.
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Pintschovius, Lars. "Kooperativ verteiltes Data Warehouse ein Architekturansatz für eine ganzheitliche Datenhaltung in der Hochschulverwaltung /." Mannheim : Mannheim Univ. Press, 2006. http://madoc.bib.uni-mannheim.de/mup/volltexte/2006/3/.
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Al-Mutairi, Mashael S. M. "The role of mitogen-activated protein kinase phosphates-2(MKP-2)in regulation of MAP kinase-induced inflammation in endothelial cells and macrophages." Thesis, University of Strathclyde, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488525.
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Mitogen-actWated protein kinase phosphatases (MKPs) are a family of dualspecificity phosphatases known to regulate the activity of the mitogen-activated proteins kinases (MAP kinases). MKP-2 was one of the earliest MKPs to be identified and characterised as a nuclear MKP. It is abundantly expressed in most tissues and induced in response to different range of stimuli.
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Brunton, Adam North. "MCP optics." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/35847.
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This thesis is an account of research into a novel type of X-ray optic - the microchannel plate (MCP). Experiments to determine the point to point focusing properties of square pore MCPs manufactured by Galileo Electro-Optics and Philips Photonics are reported. These were performed both in a test chamber at Leicester with an electron-bombardment X-ray source and with a laser-plasma X-ray source at the Rutherford Appleton Laboratory. A resolution of 6 arcmin and an intensity gain of 20 were recorded using a Galileo focusing MCP. An invesigation into the focusing action of MCPs which have been curved to a spherical figure is detailed. Such curved MCPs may, in a manner reminiscent of a conventional refractive lens, be used to focus a parallel X-ray beam to a point forming the basis of an X-ray telescope, or conversely to convert the diverging beam from a point-like X-ray source to a quasi-parallel one. The curving experiments were performed by Philips Photonics on standard circular pore MCPs. Tests on these plates were performed at Leicester; the results appear favourable. The technique has been applied to MCPs of up to 4mm thickness, curving them to a radius of 1.4m (0.7m focal length). A comprehensive Monte Carlo ray-tracing model is presented. This was initially developed to facilitate an understanding of the geometry of MCP focusing and to produce idealised images corresponding to a given experimental set up. These perfect images may be compared with, or used to predict experimental results. Comparison with experimental results led to incorporation of MCP distortions into the code. These distortions have been found by a programme of metrology which is also described. The model has led to a clear insight into the causes of poor image quality and their relative importance.
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Galván, Oré Liliana. "Mind Map." Universidad Peruana de Ciencias Aplicadas - UPC, 2006. http://hdl.handle.net/10757/272396.
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Morgan, Thomas D. M. Eng Massachusetts Institute of Technology. "Map folding." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77030.
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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 55).<br>In 1997, Jack Edmonds posed as an open problem the computational complexity of deciding whether a given m x n map-rectangular paper with horizontal and vertical creases, each marked mountain or valley-has a flat folded state. This problem has remained open since then, even for the 2 x n case. This thesis presents several theoretical contributions to this problem. Most significantly, it presents an O(n⁹ ) time algorithm for deciding the flat foldability of a 2 x n map. To achieve this result, this thesis makes a sequence of reductions which ultimately lead to a new general hidden tree problem, where the goal is to construct a "valid" tree on a given polynomial set of candidate vertices, given oracles to navigate hypothetical partially constructed trees. To complete the algorithm, it is shown that the hidden tree problem can be solved in polynomial time using dynamic programming. Additionally, several faster algorithms are given for special cases of 2 x n map folding. This thesis goes on to extend this algorithm to optimization variants of the problem. In particular, by certain metrics it finds the simplest flat folded state achievable by a given 2 x n map in polynomial time. This thesis also provides results for the general m x n map folding problem. It presents a set of nontrivial necessary conditions for an m x n map to be flat foldable, that are checkable in polynomial. Additionally, this thesis presents a fixed parameter tractable algorithm for the m x n map folding problem, where the parameter is the entropy in the partial order induced by the mountain valley pattern on the cells of the map.<br>by Thomas D. Morgan.<br>M.Eng.
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Caycho, Rodríguez Juan Javier, Landeo Aleksandra Morales, Cruz Ambar Herlinda Valerio, and Alejos Kelly Yolanda Vila. "Bus Map." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/623987.
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El plan de negocio que desarrollamos en la presente tesis consta de la creación de una empresa orientada a brindar información en tiempo real a través de un aplicativo móvil que busca mejorar la experiencia del usuario de trasporte público.
La metodología de este plan de negocio consistió en realizar un estudio de mercado para definir el cliente objetivo y un modelo de negocio que sea interesante para ellos. Además, incluimos un plan de marketing, finanzas y organizacional.
El servicio a ofrecer consiste en un aplicativo móvil (app) que tomará la experiencia de los aplicativos de servicio de taxi y la tecnología GPS para rastrear las unidades de transporte público en tiempo real, de modo que se pueda conocer el momento exacto en el que llegarán las unidades a los paraderos más cercanos al usuario.
Nuestro segmento de clientes son los usuarios de transporte público de Lima Metropolitana que posean un dispositivo móvil y tengan la experiencia de interactuar con aplicativos móviles y forman parte de la Población Económicamente Activa (PEA) y sus edades oscilan entre los 24 y 44 años.
En base a esta oportunidad identificada se ha diseñado una serie de estrategias a nivel operacional, marketing, recursos humanos y finanzas, para llegar a cada uno de ellos con algunos atributos que lo diferencian de la competencia actual.
La compañia a crear tendrá la visión de ser una empresa líder global en información del transporte público en las grandes metrópolis, comprometidos con la excelencia en la calidad de la información, tecnología de punta e innovación.
A nivel operativo se traza una meta de generar rentabilidades superiores al 20%
Para cumplir con estos propósitos se requiere de una inversión inicial de S/2,539, 010 que se destinará a la adquisicón de activo fijo y gestión operativa de los primeros 5 meses de operación de la empresa.<br>The business plan that we develop in the present thesis consists in the creation of a company orientated to offering real time information with a mobile app to improve the experience of trasport users. The methodology of this business plan consists in realizing a market research to define the client´s objectives and a business´model interesting for them. In addition, we include a marketing, finance and organizational plan.
The service consists of a mobile app that will take the experience of taxi´s apps and the GPS technology to trace public transport units in real time, so that they could know the exact moment in which the units will come to the nearest transports´ terminal. Our clients' segment, the public transport´s of Lima Metropolitana who possess a mobile device and have the experience of interacting with mobiles apps and form a part of the Economically Active Population (PEA) and their ages range are between 24 and 44 years.
On the basis of this opportunity a series of strategies has been designed at operational, marketing, human resources and finance level, to come to each of them with some attributes that separate it from the current competition. The company will have the vision of being a leading global company in public transport information in big metropolis, compromised with the excellence in the quality of the information, top technology and innovation. At operative level, our goal is to generate superior profitabilities up to 20%, to acomplish that is required an initial investment of S/2,539,010 that will be destined to the adquisition of fixed assets and operative management for the first 5 months of company operations.<br>Tesis
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Quiroz, Sciaraffia Tamara Andrea. "MOP Valparaíso." Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/100172.
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El proyecto establece un proceso de modernización del MOP se desarrolla en dos líneas complementarias y convergentes: una es la llamada “Infraestructura 2020” que consiste en una proyección de ese año, para saber qué infraestructura necesitará Chile y, sobre esa base, qué organización se requiere para llevarla a cabo. La segunda es una “Reforma Integral” para fortalecer las áreas estratégicas del Ministerio como la planificación, gestión de contratos y de proyectos, estándares de servicio y fiscalización. Esta línea incluye la reforma organizacional a través de una nueva estructura legal y organizacional que definirá los nuevos roles y responsabilidades del MOP.
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Pereira, Márcia Regina de Sousa. "Iniciativa MAP." Florianópolis, SC, 2007. http://repositorio.ufsc.br/xmlui/handle/123456789/90305.
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Dissertação (mestraddo) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Programa de Pós-Graduação em Direito.<br>Made available in DSpace on 2012-10-23T08:21:12Z (GMT). No. of bitstreams: 1
247960.pdf: 622595 bytes, checksum: 2e2d4b1675ba5c3d7b9a0b5042a3d0d6 (MD5)<br>Desde o nascimento do capitalismo forças sociais emergem em busca de melhores condições de vida e acesso a direitos. São nesses momentos de efervescências decorrentes das relações sociais, culturais, políticas e econômicas que se formam os movimentos sociais como contraponto de reivindicação e afirmação. Nesse sentido, o presente trabalho analisa o movimento denominado iniciativa MAP # Madre de Dios (Peru), Acre (Brasil) e Pando (Bolívia), e sua gestão para o desenvolvimento sustentável em pleno curso na Amazônia Sul Ocidental, região de fronteira trinacional, nessa era de globalização. A globalização, em sua face econômica, promove um jogo assimétrico em que a ideologia neoliberal é imposta aos Estados-nação, enfraquecendo as economias nacionais e fazendo com que esses atores políticos se submetam a atrair todo e qualquer investimento que, no mais das vezes, não respeitam as regras de proteção ao meio ambiente. Na região fronteiriça MAP realiza-se a construção da Rodovia Interoceânica, que interligará os portos do Brasil a Lima, no Pacífico, concebida no âmbito da Iniciativa de Integración de la Infraestructura de Sudamérica (IIRSA) para promover a integração sul-americana, o desenvolvimento da região da Amazônia Sul Ocidental e, ainda, integrar o Brasil, o Peru e a Bolívia aos mercados da Ásia e Japão. O impacto da realização dessa obra no ecossistema amazônico e nos municípiosdistritos
fronteiriços, bem como em suas populações, impulsionou a articulação social denominada iniciativa MAP, fundada nos princípios do desenvolvimento sustentável e direitos humanos, que mobiliza há sete anos instituições, organizações não-governamentais, indígenas e campesinos, enfim, a sociedade fronteiriça, em um movimento de resistência ao desenvolvimento excludente e degradador impulsionado pelo processo da globalização, reivindicando o direito de participar das decisões sobre o desenvolvimento da região. O MAP no atual estágio pode ser considerado um emergente movimento social transfronteiriço de resistência ao modo imperativo pelo qual se constrói a estrada Interoceânica na Amazônia Sul Ocidental, promovendo ações dialéticas de um pensar-agir voltadas para a gestão do desenvolvimento sustentável.
Since the advent of Capitalism, social forces emerge in claim better conditions of living and access to their rights. It#s in these moments of agitation, consequences of social, cultural, political and economical relations, that the social movements in counterpoint to claim and affirmation. In this sense, the present paper analyzes the movement called MAP # Madre Dios (Peru), Acre (Brasil) and Pando (Bolívia), and it also aims to analyze the management over the sustainable development, in total course, in the South Occidental Amazon, the three-national-boundary region, in globalization times. Globalization, in its economical stage, promotes an asymmetrical game, in which, the neoliberal ideology is imposed upon the state-nations, as it weakens the national economies and makes these political actors being submitted to all and any kinds of investments that, in most times, don#t comply with the environmental regulations of protection. In the boundary region (MAO), an interoceanic highway has been built, and it will connect to harbors, one in Brazil and the other in Bolivia (Lima), in the Pacific, as the highway had been concepted in the Integración de la Infraestrutura of Sudamerica (IIRSA), in order to promote the South american integration, the development of the South Occidental Amazon, and yet, to integrate the countries: Brazil, Peru and Bolivia, with the market of Asia. The impact of the achievement of this work into the Amazon ecosystem has led to a social articulation called MAP initiative, based on the principles of sustainable development and on the human rights, that has moved institutions, nongovernmental organizations, Indian tribes, countrymen, for over seven years. It also has encouraged the formation of a movement of resistance to the degrading and excluding development driven by the globalization process, claiming the right to taking part on decisions over the development of the region. The MAP, in the recent stage, may be considered as a resistant emergent social movement that aims to protect the environment from the imperative way, in which, the Interoceanic highway has been built, as also a movement that promotes dialectical actions on a way of thinking and acting focused on the management of sustainable development.
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Holík, Tomáš. "MHP aplikace." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217253.
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This Master Thesis is engaged in designing an interactive application for online betting in the DVB-T environment. The application is determined to running at Multimedia Home Plattform MHP and it allowes digital television viewers to make a bet on a sport match broadcasted on the television. The whole application is written in the Java language. All the information about users and the match are stored in a MySQL database, which is accessible through a php script placed on the server with the database. The applicaton is running in a set-top box and communicates with the script through the set-top box return channel. The channel between the server and the script is unsecure, so the communication has to be encrypted. The encryption process uses a symmetric-key cipher AES, which uses a shared secret key for encryption and decryption. Each application generates its own pseuodorandom and crypthographicaly strong AES key and sends it to the server. To secure the secret key transsmision is used the public-key cipher RSA.
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Saheban, Reza. "Knowledge Map : Do Organizations Take Advantage of Knowledge Map+." Thesis, Jönköping University, JIBS, Business Informatics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-498.
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Ellis, Lucy C. J. "Human and rat multidrug resistance-associated proteins (MRP/Mrp)." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=128325.
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The multidrug resistance associated proteins (MRP(human)Mrp (rat) are ATP-dependent transporters responsible for the efflux of a wide range of substrates, including endogenous compounds e.g. bilirubin, drug metabolites e.g. paracetamol glucuronide and fluorescent dyes e.g. 5 (and 6)-carboxy-2’,7’-dichlorofluorescein (CDF). Mrp1-6 (<i>abccl-6)</i> are expressed in rat liver, with Mrp2 being expressed at the highest level. Isolation of hepatocytes by <i>in situ</i> collagenase perfusion causes bile canalicular disruption and internalisation of Mrp2. Cells cultured in a sandwich configuration of Matrigel or collagen (Type 1) showed bile canalicular reformation at different days in cell culture, depending on the extracellular matrix and time of overlay. We have developed a method for quantifying Mrp-mediated efflux in hepatocytes cultured in a sandwich configuration of collagen (Type 1). This method is unique in its ability to distinguish between sinusoidal efflux, canalicular efflux and diffusion in intact hepatocytes. Alternative <i>in vitro</i> models of Mrp2-mediated efflux include the vesicular (direct and indirect methods) and the ATPase assays. We have used these assays to identify atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin as substrates of human and rat MRP2/Mrp2. A close correlation was seen between the kinetic parameters of transport of the Mrp2 substrate; CDF determined in sandwich cultured rat hepatocytes using the method above (Km = 3.5 – 9.9 μM), vesicle preparations (Km = 37.9 μM) and membrane preparations (Km = 18.7 μM). We also present data to implicate the nuclear receptors, PXR, CAR and FXR in the regulation of <i>abcc2</i> and <i>abcc3</i> and PXR and CAR in <i>abcc1</i> gene regulation. <i>Abcc2 </i>and abcc5<i> </i>are also up-regulated in response to a toxic insult to the cell, probably via Nrf2 activation, suggesting a role in cell defence.
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Torkul, Orhan. "A comparison of MRP/GT and MRP/JS scheduling." Thesis, Cranfield University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333138.
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Jin, Z. "Depth-map-assisted texture and depth map super-resolution." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/3000968/.
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With the development of video technology, high definition video and 3D video applications are becoming increasingly accessible to customers. The interactive and vivid 3D video experience of realistic scenes relies greatly on the amount and quality of the texture and depth map data. However, due to the limitations of video capturing hardware and transmission bandwidth, transmitted video has to be compressed which degrades, in general, the received video quality. This means that it is hard to meet the users’ requirements of high definition and visual experience; it also limits development of future applications. Therefore, image/video super-resolution techniques have been proposed to address this issue. Image super-resolution aims to reconstruct a high resolution image from single or multiple low resolution images captured of the same scene under different conditions. Based on the image type that needs to be super-resolved, image super-resolution includes texture and depth image super-resolutions. If classified based on the implementation methods, there are three main categories: interpolation-based, reconstruction-based and learning-based super-resolution algorithms. This thesis focuses on exploiting depth data in interpolation-based super-resolution algorithms for texture video and depth maps. Two novel texture and one depth super-resolution algorithms are proposed as the main contributions of this thesis. The first texture super-resolution algorithm is carried out in the Mixed Resolution (MR) multiview video system where at least one of the views is captured at Low Resolution (LR), while the others are captured at Full Resolution (FR). In order to reduce visual uncomfortableness and adapt MR video format for free-viewpoint television, the low resolution views are super-resolved to the target full resolution by the proposed virtual view assisted super resolution algorithm. The inter-view similarity is used to determine whether to fill the missing pixels in the super-resolved frame by virtual view pixels or by spatial interpolated pixels. The decision mechanism is steered by the texture characteristics of the neighbors of each missing pixel. Thus, the proposed method can recover the details in regions with edges while maintaining good quality at smooth areas by properly exploiting the high quality virtual view pixels and the directional correlation of pixels. The second texture super-resolution algorithm is based on the Multiview Video plus Depth (MVD) system, which consists of textures and the associated per-pixel depth data. In order to further reduce the transmitted data and the quality degradation of received video, a systematical framework to downsample the original MVD data and later on to super-resolved the LR views is proposed. At the encoder side, the rows of the two adjacent views are downsampled following an interlacing and complementary fashion, whereas, at the decoder side, the discarded pixels are recovered by fusing the virtual view pixels with the directional interpolated pixels from the complementary downsampled views. Consequently, with the assistance of virtual views, the proposed approach can effectively achieve these two goals. From previous two works, we can observe that depth data has big potential to be used in 3D video enhancement. However, due to the low spatial resolution of Time-of-Flight (ToF) depth camera generated depth images, their applications have been limited. Hence, in the last contribution of this thesis, a planar-surface-based depth map super-resolution approach is presented, which interpolates depth images by exploiting the equation of each detected planar surface. Both quantitative and qualitative experimental results demonstrate the effectiveness and robustness of the proposed approach over benchmark methods.
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Vaughan, Owen. "The r-map, c-map and black hole solutions." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/8953/.
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We consider various geometrical and physical aspects of the r-map and c-map, which are two maps induced by the dimensional reduction of 5d and 4d, N = 2 supergravity coupled to vector multiplets respectively. We treat reduction over a spacelike or timelike dimension on an equal footing, and prove, for the first time, that the target manifold in the image of the timelike c-map is para-quaternion Kahler. In order to do this we provide a new formulation of projective special Kahler geometry based on real Darboux coordinates, which is useful both mathematically and physically in its own right. As an application we investigate how the r-map and c-map can be used to generate new stationary black hole solutions. In four dimensions we construct new extremal non-BPS solutions, and in both four and five dimensions we construct new non-extremal solutions. We also take the first steps towards constructing new rotating solutions, though at this stage we only recover known solutions. The systematic and geometrical nature of these constructions allows us to gain a deeper understanding of many familiar properties of black holes in supergravity, such as the attractor mechanism and the transformation of BPS into non-BPS black holes using a field rotation matrix. We also observe an interesting and novel feature relating to non-extremal black holes: in order for solutions to correspond to non-extremal black holes with finite scalar fields we find that the number of integration constants must reduce by half. This suggests that non-extremal black holes always satisfy first order equations similar to their extremal counterparts. For STU-like models all calculations are performed explicitly.
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Xie, Ming. "Rethinking Map Literacy and an Analysis of Quantitative Map Literacy." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7989.
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Maps are increasingly being used in traditional and virtual media, and civic discourse on political, social, and environmental issues, among others, is more and more becoming influenced by them. The often-used expression of a “picture tells a 1000 words” has never been so apt in our progressively more visual world. Despite this increased role and importance of maps, map literacy, as a field of research, remains rather underdeveloped. This is especially so for thematic maps, the very type of map that is finding increasing currency in discourse. As part of this under-developed nature of map literacy, the quantitative skills used in map reading and interpretation have not been systematically investigated, and previous commentary on the subject has been limited to listings of relatively low-level skills. As modern technologies, such as GIS, enable the more sophisticated production of maps, their interpretation can come to depend on more advanced quantitative literacy. The quantitative literacy required for map interpretation can also be expected to vary significantly with the type of map, and while map literacy studies generally recognize the broad distinction of reference and thematic maps, they do not provide a more nuanced framework for investigating how quantitative literacy may vary both within these broad categories and for maps which overlap these categories.
This dissertation represents a first attempt to address these issues, and at least provide conceptual frameworks for their investigation. For the first conceptual framework, the dissertation introduces a three-set Venn model to discuss the content and relationships of three “literacies”: map literacy, quantitative literacy, and background information. As part of this, the field of Quantitative Map Literacy (QMP) is introduced and defined as the knowledge (concepts, skills and facts) required to accurately read, use, interpret, and understand the quantitative information embedded in geographic backgrounds. It is conceptualized as the intersection of the Map Literacy and Quantitative Literacy “sets”. The dissertation also introduces the conceptual framework of a compositional triangle based on the ratio of reference to thematic map purpose and the level of generalization/distortion within maps. This framework allows for any type of map to be located within the triangle and then related to the type and level of quantitative literacy they demand. Finally, based on these two frameworks, the dissertation uses the pedagogical tool of “word problems” to explore the variability of map reading skills and knowledge, and does this for specific map examples.
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Rodgren, Staffan. "Android Map Application." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177260.
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Nowadays people use maps everyday in many situations. Maps are available and free. What was expensive and required the user to get a paper copy in a shop is now available on any Smartphone. Not only maps but location-related information visible on the maps is an obvious feature. This work is an application of opportunistic networking for the spreading of maps and location-related data in an ad-hoc, distributed fashion. The system can also add user-created information to the map in form of points of interest. The result is a best effort service for spreading of maps and points of interest. The exchange of local maps and location-related user data is done on the basis of the user position. In particular, each user receives the portion of the map containing his/her surroundings along with other information in form of points of interest.
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Jonsson, Erik, and Mikael Persson. "MDP for Symbian." Thesis, Linköping University, Department of Computer and Information Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14703.
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<p>The content of this report describes a bachelor thesis performed on commission by Cybercom Sweden West. The report describes techniques, methods and development tools used during the project. The purpose of this project is to demonstrate the usefulness with a new Bluetooth profile called Medical Device Profile (MDP) on the Medica trade fair 14-11-2007. The MDP profile that will be released in turn of the ear 07/08 is primarily intended to be used in medical devices.The demonstration is to be made by building a demonstrator consisting of an application running on a smartphone with Bluetooth abilities. The application will handle the Bluetooth connection between the smartphone and the oximeter, the data encryption and other functionalities and presenting the figures received form the oximeter in a Graphical User Interface (GUI).The final demonstrator consists of a smartphone application programmed in Symbian C++, which communicates with the oximeter using the Bluetooth Serial Port Profile (SPP). The application runs on UIQ 3.0 based smartphones and displays heart rate and %SpO2 (The percentage of oxygen saturation in blood), which the application receives from the oximeter.The original idea was to use the MDP profile by porting Cybercom's C version of the MDP to Symbian OS for the Bluetooth communication, depending on various factors described more in detail inside the report this was not done. The purpose of the project was still reached, even though another profile then MDP was used. This was done by replacing the considered oximeter for an older version which is using the SPP. By using SPP the same result will be demonstrated but with an older technique, and this will achieve the same result on Medica trade fair. The project was demonstrated on Medica with a successful result.</p>
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Iturriaga-Velazquez, Claudia C. "Map labeling problems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0002/NQ44766.pdf.
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Pungthong, Viriya. "Port-a-map /." Online version of thesis, 1988. http://hdl.handle.net/1850/11533.
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Lima, Mirian Késia Labs de. "Movimento social MAP." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/92102.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas, Programa de Pós-Graduação em Direito, Florianópolis, 2008.<br>Made available in DSpace on 2012-10-24T05:46:57Z (GMT). No. of bitstreams: 0<br>A história da humanidade revela uma participação marcante de atuação dos movimentos sociais na luta pela conquista e defesa de direitos. Ficando mais evidente estas ações a partir da afirmação do capitalismo, da Segunda Guerra Mundial e, atualmente a formação de uma sociedade globalizada. Com esta direção, o presente trabalho analisa a Iniciativa MAP Madre de Dios (Peru), Acre (Brasil) e Pando (Bolívia), e sua emergência como paradigma transfronteiriço de atuação nas relações transnacionais envolvendo os indivíduos, entidades e unidades estatais dos três países formadores da região MAP. A globalização e os avanços tecnológicos são fatores que impulsionaram a criação de novos movimentos sociais, novos paradigmas das relações internacionais e têm influenciado no enfraquecimento e fragilidade do Estado-nação. Esse enfraquecimento não está apenas ligado a soberania e atuação absoluta do Estado, mas como também, no enfraquecimento das economias. Fato que possibilita a busca por um desenvolvimento desenfreado e sem qualquer preocupação com o meio ambiente, com os indivíduos locais e sustentabilidade da vida. Na região MAP a preocupação latente versa exatamente no binômio desenvolvimento e sustentabilidade, baseado nos princípios éticos de participação e informação, buscando efetivar cooperação e integração local. O MAP consolidado como movimento social transfronteiriço está se pronunciando como emergente paradigma transfronteiriço complementar do paradigma transnacionalista, porque impulsionado pela formação de uma teia de distribuição e receptação de informações, reconhece as relações transnacionais como instrumento de expressão de justiça e dignidade.
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Pospíšil, Josef. "Digitalizace historických map." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2008. http://www.nusl.cz/ntk/nusl-235934.
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This work is about processing of historical maps, especially their digitizing and vectorization. The main focuses of this project are maps from the second historical military mapping and finding methods useful for removing texts from these maps.
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Shenker, Maura Ilan. "Vandalized love map." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1334336622.
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Hálková, Gabriela. "Bariéry internacionalizácie MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-16537.
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The thesis focuses on the barriers to the internationalization of SMEs. The theoretical part consists of four chapters outlining the basic theoretical resources necessary for the practical part. The first part explains the nature of internationalization and globalization, the second defines SMEs in the Czech Republic and the European Union, the third section presents the most important and most common barriers to the internationalization of SMEs, the last fourth part provides an overview of the institutions involved in export promotion in the Czech Republic. The practical part of the thesis consists of an analysis sample of four companies that led to the determination of the largest and most common barriers to the internationalization of Czech SMEs.
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Celbová, Monika. "Podnikatelský plán MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-18155.
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The study presents a business plan for a firm which offers fishing services. The study consist of a theoretical part and a practical part. In the theoretical section the small and medium enterprises are specified, especially the family business and there are characteristics of the form, structure and terms of the business plan. The practical section focuses on elaboration of the business plan for the particular firm. It includes description of all activities, market analysis, financial plan, SWOT analysis, break-even point analysis and potential risks. As a result the study provides an examination of a feasibility of the business plan.
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Přidálek, Michal. "Podnikatelský plán MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75583.
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The main aim of this graduation thesis is to create a business plan for an emerging business. The theoretical part briefly describes the concept of entrepreneurship. The basis of the theoretical part is representation of various chapters in the structure of the business plan The main part of the graduation thesis is the practical part, which contains a full version of a business plan for the company MaxiMini Ltd, which deals in shoes for people with special size requirements. The author first deals with basic information about the project and then goes on to describe the principles of a business opportunity, goals and business strategy. Then follow detailed product (and its need) characteristics, a description of services, location and potential suppliers. The marketing analysis examines competition, overall and target markets, prices and marketing. The financial part evaluates capital expenditure and operating costs, which together form the source for financial statements in three versions of possible future progress, followed by a recovery calculation of investment. In the conclusion the whole project is evaluated by means of SWOT and risk analysis.
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Oppolzerová, Eva. "Podnikatelský plán MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-76800.
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The diploma thesis focuses on developing a business plan to project Cinema-café. The goal is an overall assessment of the viability of the business plan, developing the financial plan, marketing strategy, SWOT analysis, evaluation of project risks and their elimination.
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Machová, Adéla. "Podnikatelský plán MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-85366.
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Master's thesis on the topic Business plan of SME introduces theoretical description of business plan, where it describes reasons of being of the business plans and entrepreneurship and then individual points of business plan. That includes setting up the targets of the company, description of business activities using different methods till financing. Practical part creates new business plan. This plan starts a restaurant as a first step for future franchise chain. The target of the thesis is development of business plan and verifying it's feasibility. Theoretical part will be straightly implemented to the development of the practical part.
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Beránková, Alena. "Podnikatelský plán MSP." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198459.
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The aim of this thesis is to create a business plan for a start-up enterprise acting in the hospitality industry with an emphasis on a healthy lifestyle. The thesis consists of two main parts, theoretical and practical. The theoretical part, based on the literature, provides the reader with methodological procedures, which are applied in the plan. At First there are described the basic concepts of business and general recommendations in connection with this issue, next parts are the structure of the business plan. The practical part is the real business plan. Equally important part of the work is the conclusion which summarizes the findings identified in the practical part, about the benefits and feasibility of the project.
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González, Islas Verónica. "M.P. Virtual 2.0." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/105324.
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Reis, Sabrina Thalita dos. "Análise da expressão de MMP-2, MMP-9, MT1-MMP (MMP-14), TIMP-1, TIMP-2, RECK, TGF-Beta e interleucina-8 em câncer de próstata." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-22092011-133255/.
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Introdução: O câncer de próstata (CaP) é o tumor mais freqüente do homem no Brasil tendo sido estimados mais de 52.350 novos casos em 2010, sendo a segunda causa de óbito por câncer em homens. O prognóstico depende fundamentalmente dos níveis séricos de Prostatic Specific Antigen (PSA) estádio tumoral (TNM) e grau de diferenciação histológica (Gleason). Porém esses têm sido insuficientes na definição do prognóstico da neoplasia. Por isso pesquisas têm sido direcionadas para a identificação de alterações moleculares que possam prever o potencial de agressividade do câncer de próstata. Metaloproteinases da matriz (MMP) são proteínas pertencentes a uma família de aproximadamente 30 enzimas proteolíticas ou endoproteinases que degradam vários componentes da matriz extracelular. A detecção de sua expressão tem sido estudada como marcador sensível e específico de vários tumores, principalmente as MMP pertencentes ao grupo das gelatinases MMP-2 e MMP-9. Objetivo: o objetivo deste nosso trabalho foi avaliarmos pela técnica de qRT-PCR e imuno-histoquímica os níveis de expressão dos genes das MMP pertencentes ao grupo das gelatinases, MMP-2 e MMP-9, bem como outros sabidamente envolvidos em suas vias de ativação (MMP-14, IL-8) e inibição (TIMP-1, TIMP-2, RECK e TGF-) no câncer localizado de próstata. Material e Métodos: O estudo consistiu na análise de espécimes de 79 pacientes com câncer da próstata submetidos a prostatectomia radical entre setembro de 1997 e fevereiro de 2000. Esses oito genes foram então testados quanto a seu valor prognóstico no câncer da próstata através da técnica de reação em cadeia da polimerase quantitativa com transcriptase reversa (qRT-PCR). Análise proteica foi feita a partir de 40 pacientes deste pool. O grupo controle foi composto de tecido de 11 pacientes com hiperplasia benigna da próstata (HPB) tratados cirurgicamente com prostatectomia retropúbica. Resultados: MMP-9 esteve superexpressa e MMP-2, TIMP-1, TIMP-2, MMP 14, IL-8, TGF- e RECK se mostraram subexpressos em tecido representativo de CaP quando comparado com HPB. A análise dos níveis de expressão dos genes com o escore de Gleason, mostrou que MMP-2 e TIMP-2 mesmo mantendo-se subexpressos, tiveram uma expressão maior entre os pacientes que apresentavam Gleason 7 (p=0,04 e p=0,02 respectivamente). De acordo com o valor de PSA préoperatório, encontramos diferenças na expressão de MMP-9. Pacientes que apresentavam um PSA pré-operatório 10 ng/mL possuíam uma mediana de expressão maior que aqueles cujo PSA pré-operatório <10 ng/mL com medianas de expressão de 5,62 e 2,76 respectivamente (p=0,033). Não encontramos diferenças estatísticas entre pacientes que apresentavam ou não recidiva bioquímica quanto a expressão dos 8 genes estudados. Porém o gene da MMP-9 apresentou uma diferença estatística marginal apresentando uma mediana de expressão de 6,29x nos pacientes que apresentaram recidiva bioquímica e de 3,25 nos pacientes que não apresentaram recidiva bioquímica (p=0,090). De acordo com a expressão proteica, encontramos uma maior positividade em MMP-9, MMP-2, TGF-, IL-8 e MMP-14. De acordo com os fatores prognósticos encontramos associação de TIMP-1 com recidiva bioquímica. Conclusão: Encontramos uma superexpressão de MMP-9 e uma subexpressão de MMP-2, TIMP-1, TIMP-2, MMP-14, RECK, IL-8 e TGF- no CaP. Considerando os fatores prognósticos encontramos que aumentados níveis de expressão do gene da MMP-9 associou-se a aumentados níveis de PSA, e mostrou uma tendência de associação com recidiva bioquímica. De acordo com a expressão proteica encontramos que a ausência de TIMP-1 pode ser um indicativo de recidiva bioquímica<br>Introduction: Currently, Prostate cancer (PCa) is the most common tumor in men in Brazil. It was estimated that more than 52,350 new cases were diagnosed in 2010, being the second cause of death by cancer in man. The prognosis depends mainly on Prostate Specific Antigen (PSA) serum levels, tumor stage (TNM) and histological grade (Gleason), but these parameters, even combined, are insufficient to define the correct prognosis of PCa. Therefore research has been directed towards the identification of molecular alterations that may predict potential aggressiveness of PCa. Matrix metalloproteinases (MMPs) are proteins that belong to a family of about 30 proteolytic enzymes that degrade various components of the extracellular matrix. The analysis of MMPs expression has been studied as a sensitive and specific marker of prognosis of several tumors, and special attention was focused in the group of gelatinases, MMP-2 and MMP-9.Objective: The aim of this study was to evaluate the expression levels of MMP-2 and MMP-9 genes and proteins by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry in localized PCa. We also evaluated the expression of genes that are involved in the control of MMP-2 and MMP as activators (MMP- 14, IL-8) or inhibitors (TIMP-1, TIMP-2, RECK and TGF-).Materials and Methods: The casuistic consisted of 79 surgical specimens from patients with localized PCa who underwent radical prostatectomy between September 1997 and February 2000. The control group was composed of specimens from 11 patients with benign prostatic hyperplasia (BPH) treated surgically with retropubic prostatectomy. The results of the 8 genes expression, through qRTPCR and immunohistochemistry, were correlated to the diagnosis and prognosis of PCa. The protein expression analysis was carried out in 40 patients of the casuistic. Results: The MMP-9 was overexpressed, while MMP-2, TIMP-1, TIMP-2, MMP-14, RECK, IL-8, and TGF- were underexpressed in malignant prostate tissue compared to BPH. Patients with Gleason7 had higher expression of MMP-2 and TIMP-2 (p=0.04, p=0.02 respectively). According to the preoperative PSA value, we found that patients with preoperative PSA10 ng/mL had a median of expression of 5.62 compared to 2.76 when PSA<10 ng/mL (p=0.033). There were no statistical differences between expression of the eight genes and biochemical recurrence during follow up. However, the higher MMP-9 expression was marginally associated with recurrence, the median was of 6.29 in recurrence patients compared to 3.25 in those without recurrence (p=0.090). Regarding the protein expression, we found a higher positivity of MMP-9, MMP-2, TGF-, IL-8 e MMP-14 expression in PCa, and a correlation between the lack of TIMP-1 and tumor recurrence. Conclusion: MMP-9 is overexpressed while MMP-2, TIMP-1, TIMP-2, MMP-14, RECK, TGF- and IL-8 are underexpressed in CaP. According to the prognostic factors, we observed that increased level of MMP-9 was associated with pre-surgical PSA10 ng/mL. Also there was a tendency of association between higher MMP- 9 expression and biochemical recurrence. Overexpression of MMP-9 can be explained by the underexpression of their major inhibitors TIMP-1 and RECK. According to protein expression we found that absence of TIMP-1 is correlated with biochemical recurrence in the PCa
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Brandel, Mikael C., and Mohammad H. Syarif. "Improving business to customer communication : Applying lean and information and communication technologies." Thesis, KTH, Industriell produktion, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50400.
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In this current economical environment business are looking to become more efficient to lower the costs and provide a better service. New technological advances are quickly being integrated to automate or more rapidly perform the task. Most of these technological advances are in the field of information and communication technology (ICT). Nevertheless, the introduction of technologies is not enough, as better management strategies and organization structures are needed to develop the business further. Duroc Machine Tools identified a problem within the sales and service approach, which does not employ ICT tools while communicating with the customer. Therefore, the cost per order is high and a direct one to one communication is the only approach. The project focuses on lowering the cost of each order, without decreasing the customer care and the overall quality of the service. This was firstly done by studying the possibilities of what ICT tools would be applied to enhance the communication processes. Data was collected from statistical sources to give an overall idea. Next case studies of companies within similar industries and region were performed to indicate in more detail the tools used and available. An educated guess was formulated of what ICT tools should be considered, the more infrequent or conflicting ICTs recommended were verified by interviewing employees with a demonstration of the tools application. The second stage was to analyze the organizational structure and applying lean tools to add value to the customer. A customer perspective is at the centre of this theory and several tools were used to improve the system. Finally the ICT tools were integrated with the new organizational structure to demonstrate the developments possibilities in the future vision. The study found that common ICT functions such as information upload have become essential for doing business today. Another trend that was established is that live information or user-generated approach which is a must have factor in the future ICT platform, this was mostly suggested by introducing micro-blogs. The infrequent and conflicting ICTs within the industry that were recommended were: e-commerce, order management and model driven process solving (MDP). The verification showed a strong consent within the company to apply such tools. To finish the project a strategy of implementation was formulated to guide the company towards its vision of a better system.