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Catelotti, Franco, Silvina Trossero, Roxana Alicia Marcos, Daniel Romero, María Silvina Lo Presti, and Gladys Barboza. "Goniometría del movimiento de flexo-extensión de tobillo: análisis comparativo entre método de referencias óseas y método 0 neutral." Revista de la Facultad de Ciencias Médicas de Córdoba 77, no. 4 (2020): 276–80. http://dx.doi.org/10.31053/1853.0605.v77.n4.27655.
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Introducción: En la goniometría de tobillo se utilizan dos métodos diferentes, el método cero neutral (M0N) y el método de referencias óseas (MRO). Además, el M0N tiene un subtipo (M0I), con una técnica diferente. Objetivo: Determinar el promedio de la amplitud de flexo-extensión de tobillo, medida en diferentes posiciones corporales, utilizando M0N, M0I y MRO, en adultos jóvenes de ambos sexos, con el objetivo de aportar evidencia para que la goniometría de tobillo sea más fiable. Material y métodos: Se estudiaron 190 alumnos de la Escuela de Kinesiología y Fisioterapia, utilizando los tres métodos de medición articular en 4 posiciones corporales diferentes; se evaluó la amplitud de flexo-extensión en un tobillo por alumno. Resultados: En la mayoría de las posiciones, las mediciones fueron diferentes en los tres métodos comparados (P<0,05). Los métodos M0 y M0I arrojaron resultados similares en algunas comparaciones puntuales. La posición del paciente también influye significativamente en el resultado obtenido. La flexión dorsal de tobillo fue similar entre hombres y mujeres en la mayoría de los métodos y posiciones del paciente, no así la flexión plantar que fue mayor en las mujeres en todos los casos (P<0,0001). El valor completo de flexo-extensión, en la mayoría de los casos fue mayor en las mujeres que en los varones (P<0,001). Conclusiones: Tanto el método como la posición del paciente influyen significativamente en los resultados de la medición goniométrica. El género influye en la amplitud articular de la flexión plantar de tobillo, independientemente del método de medición utilizado.
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JULIEN, Christine, Dana Kumprechtová, Björn Tönepöhl, Filip Jančík, and Petr Homolka. "PSXI-33 Milk replacer formulation for dairy calves: substitution of some dairy protein by yeast-protein." Journal of Animal Science 97, Supplement_3 (2019): 409–10. http://dx.doi.org/10.1093/jas/skz258.812.
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Abstract Eighty dairy calves from birth (d1) to weaning (d64) were reared in individual pens. One feeding program was tested with 4 different milk replacers (MR), 3 included some yeast products (Table 1). The content of crude protein (22 %), crude fat (18 %) and concentration (140 g MR per liter milk feed) was similar for all MR. Calves were divided into 4 groups at 5-d of age: (i) Control, (ii) MR1, (iii) MR2 and (iv) MR3 milk replacers. Volume distributed per calf and per meal varied with age but did not differ between groups. All calves received water and a starter concentrate (19.0% CP) ad libitum. Diarrhea scoring per calf (0 to 4), individual MR and starter intake were recorded daily whereas BW was determined every two weeks. Data were evaluated by the MIXED procedure of SAS with group, breed and sex used as fixed effects. Quality (% brix) and intake of colostrum over d1 did not differ between groups. Growth performances are altered by treatment (P = 0.05): ADG over all the experimental period was significantly lower for MR2 (0.59 kg/d) whereas it resulted similar between the 3 other groups (0.67 kg/d on average). Starter feed intake over 64d did not differ significantly between groups: 526, 501, 475 and 555 g/d on average for Control, MR1, MR2 and MR3, respectively. The MR intake over 64d was lower for MR2 (5.48 L/d) compared to Control, MR1 and MR3 (5.64 L/d, on average). There was no difference regarding diarrhea score (0.26 on average) between groups. Globally, both MR1 and MR3 led to performances similar to control MR used as reference whereas MR2 resulted more challenging for calves. Therefore, using yeast product as part of protein source for MR formulation is achievable without compromising growth performances but type of product needs to be considered.
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Franke, Georg-Nikolaus, Jacqueline Maier, Kathrin Wildenberger, et al. "Quantification of BCR-ABL with Digital PCR Results in a Significantly Lower Rate of Deep Molecular Responses When Compared to RT-qPCR in CML Patients Treated in the ENEST1st Trial." Blood 126, no. 23 (2015): 135. http://dx.doi.org/10.1182/blood.v126.23.135.135.
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Abstract Digital PCR (dPCR) generates an absolute read out that is largely tolerant to variations in PCR efficiency, reducing the requirement for standardisation like the conversion of the BCR-ABL/ABL ratio to international scale (IS). The aim of this study was to compare the results of dPCR to qPCR in blinded samples from two independent laboratories with respect to the observed rates of molecular response (MR) in CML patients (pts) having undergone 18 months of nilotinib treatment in the ENEST1st trial. A total of 230 cDNA samples from CML pts treated within the ENEST1st trial with e13 or e14/a2 BCR-ABL fusion genes were analysed in Leipzig (L, n=75) or Mannheim (M, n=155) with qPCR between 2012 and 2013. BCR-ABL levels were determined relative to those of ABL and standardization was achieved using plasmid DNA. Both labs are accredited by the European Treatment Outcome Study (EUTOS) collaboration. The cDNA samples were blinded for the qPCR results and re-analysed in L with a duplex dPCR using a QX200 Droplet Digital PCR System (BIO-RAD). In line with the manufacturer's recommendations, samples yielding a minimum of 3 positive droplets in duplicates from the 12-19.000 routinely analysed were scored as positive (+). Depth of MR was scored using the EUTOS definitions used in the ENEST1st trial. For the whole cohort, the median copy number (CN) of BCR-ABL and ABL was 12 and 59350 by dPCR and 10 and 53537 by qPCR, respectively. Both methods detected similar numbers of BCR- ABL+ samples (dPCR 186, qPCR 189) with a median % BCR-ABL 0.022 by dPCR compared 0.013 by qPCR after conversion to IS. 90% of the BCR-ABL+ samples with dPCR were within an deviation of 4.06 -fold (median 1.22 fold) from qPCR for BCR-ABL, 1.77 fold (median 1.06 fold) for ABL and 6.43 fold (median 1.72 fold) for %BCR-ABLIS. Samples from L showed median CN with dPCR and qPCR for BCR-ABL (9 and 10) and ABL (29670 and 30734) with a correlation R2 = 0.95 and 0.84. The median % BCR-ABL was 0.02% by dPCR and 0.03% before and 0.01% after conversion to IS with qPCR. 90% of the BCR-ABL+ samples by dPCR were within a range of 2.9 -fold deviation (median 0.66 fold) from qPCR for BCR-ABL, 1.9 fold (median 0.91 fold) for ABL, 2.6 fold (median 0.74 fold) for %BCR-ABL and 7.5 fold (median 1.96 fold) for %BCR-ABLIS. Samples from M had higher median CN for BCR-ABL and ABL (16 and 80000) by dPCR compared to qPCR (10 and 66570). Correlation was better for BCR-ABL compared to ABL with R2=0.95 and R2 = 0.74. The median % BCR-ABL was 0.022 by dPCR compared to 0.017 and 0.015 with qPCR after conversion to IS. 90% of the BCR-ABL positive samples with dPCR were within a deviation of 4.7 -fold (median 1.6 fold) from qPCR for BCR-ABL, 1.7 fold (median 1.1 fold) for ABL, 4.9 fold (median 1.5 fold) for %BCR-ABL and 5.6 fold (median 1.4 fold) for %BCR-ABLIS. The cumulative rates of MR3, MR4 and MR4.5 or better @ 18 months of treatment in the ENEST1st trial were 83, 43 and 29% with qPCR. The distribution in MR classes was significantly different between dPCR and qPCR (p<0.001). MR scoring by dPCR resulted in decreased cumulative rates of MR3 (-6%), MR4 (-10%) and MR4.5 or better (-11%). Significantly fewer pts achieved >=MR4 when analysed by dPCR compared to qPCR (n=77 vs. 100, p<0.05). Of the 91, 33, 44 and 23 samples scored MR3, MR4, MR4.5 or MR5 with qPCR, 71 (37%) were one (n=49), two (n=21) or three (n=1) MR classes higher with dPCR. In contrast, only 13% were scored one (n=20) or more (n=5) MR classes deeper, most likely as a result of the cut-off of 3 positive droplets. 51% of the samples were concordant (Table 1). Comparison of samples for which MR was deeper by dPCR against those for which MR was worse by dPCR than by qPCR showed no difference in ABL levels (p=0.6). Conclusions: dPCR tends to read out higher levels of BCR-ABL/ABL than standard qPCR, resulting in the placement of pts in worse MR classes. This effect does not appear to be associated with the amount or quality of material and was observed in two independent pt cohorts. Therefore, dPCR should not be used without careful evaluation and comparison to RT-qPCR. Table 1. Depth of MR according to method of quantification and lab dPCR (n) qPCR >MR3 (M/L) MR3 (M/L) MR4 (M/L) MR4.5 (M/L) MR5 (M/L) n (M/L) >MR3 37 (26/11) 1 (0/1) 1 (1/0) 0 0 39 (27/12) MR3 16 (7/9) 68 (48/20) 6 (4/2) 0 1 (1/0) 91 (60/31) qPCR (n) MR4 0 15 (10/5) 10 (6/4) 5 (3/2) 3 (3/0) 33 (22/11) MR4.5 0 15 (7/8) 12 (7/5) 9 (4/5) 8 (7/1) 44 (25/19) MR5 0 1 (1/0) 6 (5/1) 6 (6/0) 10 (9/1) 23 (21/2) dPCR n (M/L) 53 (33/20) 100 (66/34) 35 (23/12) 20 (13/7) 22 (20/2) 230 Disclosures Franke: Novartis: Other: Travel Costs; BMS: Honoraria; MSD: Other: Travel Costs. Frank:Novartis: Employment. Giles:Novartis: Consultancy, Honoraria, Research Funding. Hochhaus:ARIAD: Honoraria, Research Funding; Pfizer: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Bristol-Myers Squibb: Honoraria, Research Funding. Müller:Novartis: Honoraria, Other: CONSULTING OR ADVISORY ROLE, Research Funding; BMS: Honoraria, Other: Consulting or Advisory Role, Research Funding; ARIAD Pharmaceuticals Inc.: Honoraria, Other: Consulting & Advisory Role, Research Funding. Niederwieser:Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Lange:Novartis: Research Funding.
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Alikian, Mary, Rebecca Ellwood, Olga Tatarinova, et al. "DNA-Based Digital PCR for the Quantification of Residual Disease in CML — Sensitivity or Specificity?" Blood 132, Supplement 1 (2018): 1738. http://dx.doi.org/10.1182/blood-2018-99-117616.
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Abstract Background We have previously shown that DNA based digital PCR (dPCR) is a more sensitive approach for monitoring patients with CML in deep molecular remission compared to the 3 alternatives: qPCR, RT-qPCR and RT-dPCR. In this study we compared dPCR and RT-qPCR for their ability to predict molecular relapse in the context of national study of de-escalation of TKI dose followed by cessation of therapy (DESTINY). Methods The DESTINY study recruited 174 patients in major (or deeper) molecular remission, stratified according to whether their molecular remission status at study entry was MR3 or ≥MR4. The standard dose of TKI (imatinib, dasatinib and nilotinib) was halved at study entry and stopped 12 months later provided the patient remained in ≥ MR3. Material from diagnosis, required to clone the patient specific breakpoint for dPCR, was available only in a limited subset of patients. We cloned the breakpoints in 30 patients who reflected the range of outcomes of the study: 4 relapsed within the first 12 months of de-escalation, 12 relapsed 12-24 months from study entry (0-12 months from stopping TKI) and one relapsed 26 months from study entry (14 months from stopping therapy). All 30 patients were in ≥MR4 at study entry, of whom 7, 13 and 10 patients were in MR4, MR4.5 and MR5, respectively. Relapse was defined as loss of MR3. Fusion specific assays were designed and validated for all patients and dPCR was performed using the RainDrop platform (BioRad®). Multiple negative samples were used to establish the true positive quantification threshold per assay, including a pooled DNA samples from healthy controls and from other CML patients. Approximately 80,000 cells were included per reaction. RT-qPCR was performed according to standard protocols and all results expressed on the international scale (IS). Samples were collected at a minimum of 3 specified intervals, study entry, time of stopping TKI (month 12), month 24 and/or at the time of relapse. The log rank test was used to predict the risk of relapse and the Spearman correlation coefficient to compare the sensitivity of the two methods. Results At trial entry, patients were in MR4, MR4.5 or MR5 as defined by RT-qPCR: the depth of remission was not associated with the risk of relapse (log rank test p = 0.18 and 0.07, 0.19, 0.59 for MR4 vs MR4.5, MR4 vs MR5 and MR4.5 vs MR5, respectively). However, dPCR was positive in only 5 of the 30 patients of whom 3/5 (60%) relapsed compared to 14/25 (56%) who were dPCR negative (p=0.03). At 12 months neither the depth of remission by RT-qPCR nor the detection of malignant cells by dPCR, predicted subsequent relapse. In order to account for the fact that both methods were detecting different types of target molecules, the results were treated as a binary outcome (target detected/target not detected). 54 samples (49%) were positive by both methods, 6 (5%) were negative by both, 47 (42%) were positive only by RT-qPCR and 4 (4%) were positive only by dPCR. There was no difference in the predictive value of relapse when both methods were positive or negative. The majority of target molecules were not detected by dPCR when RT-qPCR showed transcript numbers ≤ 7 suggesting the possibility of false positivity and that dPCR is more specific in detecting true positive residual disease. Target molecules were detected by dPCR in all samples defined as > MR3 by RT-qPCR: absolute numbers of target molecules were understandably lower by dPCR (detecting cells) than by RT-qPCR (detecting transcripts). Conclusion Both methods can detect truly negative samples, however, dPCR is more specific in excluding false positivity. Neither dPCR nor RT-qPCR was capable of predicting relapse at the time of study entry. The ability of dPCR to predict loss of MR3 while off-therapy however requires the monitoring of serial time points leading to relapse before a final conclusion could be made. The question that remains posed here is the clinical validity of early residual disease detection given that, in the case of relapse (defined by ≥MR3 by RT-qPCR), all patients regain molecular remission after the TKI is reintroduced as it has been shown by all the STOP clinical trials. Disclosures Milojkovic: Incyte: Honoraria, Speakers Bureau; Novartis: Honoraria, Speakers Bureau; Pfizer: Honoraria, Speakers Bureau; BMS: Honoraria, Speakers Bureau. Clark:Pfizer: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Bristol Myers Squibb: Consultancy, Research Funding; Ariad/Incyte: Consultancy. Apperley:Novartis: Honoraria, Research Funding, Speakers Bureau; BMS: Honoraria, Speakers Bureau; Incyte: Honoraria, Speakers Bureau; Pfizer: Honoraria, Speakers Bureau.
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KISA, Ayşenur Eslem, and Oktay DEMİRCAN. "Fabrication and electrochemical performance of La 0 : 595 V 0 : 005 Sr 0 : 4 MnO 3." TURKISH JOURNAL OF CHEMISTRY 42, no. 6 (2018): 1479–98. http://dx.doi.org/10.3906/kim-1803-18.
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Poulopoulos, P., P. Isberg, W. Platow, et al. "Magnetic anisotropy and exchange coupling in FenVm(0 0 1) superlattices on MgO(0 0 1)." Journal of Magnetism and Magnetic Materials 170, no. 1-2 (1997): 57–66. http://dx.doi.org/10.1016/s0304-8853(97)00016-4.
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Shlyakhtina, A. V., S. N. Savvin, N. V. Lyskov та ін. "Polymorphism in the family of Ln6−xMoO12−δ (Ln = La, Gd–Lu; x = 0, 0.5) oxygen ion- and proton-conducting materials". Journal of Materials Chemistry A 5, № 16 (2017): 7618–30. http://dx.doi.org/10.1039/c6ta09963g.
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Arrhenius plots of the total conductivity in (1 and 3) dry and (2 and 4) wet air of two Yb<sub>6</sub>MoO<sub>12</sub> polymorphs: (1 and 2) bixbyite (Ia3̄(206)) Yb<sub>6</sub>MoO<sub>12</sub> and (3 and 4) rhombohedral (R3̄) Yb<sub>6</sub>MoO<sub>12</sub>; Yb<sub>6</sub>MoO<sub>12</sub> rhombohedral (R3̄) → Yb<sub>6</sub>MoO<sub>12</sub> bixbyite (Ia3̄(206)) at T ∼ 1600 °C.
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Fang, C. M., and Z. Fan. "Prenucleation at the Interface Between MgO and Liquid Magnesium: An Ab Initio Molecular Dynamics Study." Metallurgical and Materials Transactions A 51, no. 2 (2019): 788–97. http://dx.doi.org/10.1007/s11661-019-05495-4.
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AbstractMagnesia (MgO) particles inevitably exist in liquid Mg and may be used as potential sites for heterogeneous nucleation to achieve effective grain refinement. Understanding of the atomic configurations on MgO surfaces and in the liquid Mg adjacent to the liquid Mg/MgO interfaces is therefore of both scientific and practical interests. We investigate the surface structures of MgO in liquid Mg and the atomic arrangements of liquid Mg adjacent to liquid/substrate interfaces, using an ab initio molecular dynamics (MD) simulation technique. We find that an atomically rough terminating Mg layer forms on the {1 1 1} terminated MgO substrate (octahedral MgO) in liquid Mg. The simulations also reveal that on the structurally flat {0 0 1} terminated MgO substrate (cubic MgO) a rough Mg layer forms due to the unique chemical interactions between the ions on the substrate and the liquid metals. The surface roughness together with the large lattice misfits with solid Mg makes both octahedral and cubic MgO substrates impotent for heterogeneous nucleation of α-Mg. The present results may shed new light on grain refinement of Mg-alloys.
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Luciano, Luigia, Mario Annunziata, Maria Rosaria Esposito, et al. "Efficacy and Safety of Nilotinib in First Line Therapy in a Real Life Cohort of Chronic Myeloid Leukemia Patients." Blood 124, no. 21 (2014): 5531. http://dx.doi.org/10.1182/blood.v124.21.5531.5531.
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Abstract Introduction Consistent data show that the real goal in CML therapy is to obtain a very rapid and deep response because the cinetic of molecular response (MR) is important for quickly reducing the tumor burden by reducing the BCR/ABL level. The second generation TKIs Nilotinib was designed to have enhanced selectivity and potency toward BCR-ABL compared with imatinib and was able to obtain very rapid and deeper response as shown by many clinical trials. Nilotinib has been approved in multiple countries for use in first line therapy in CML-CP Pts. In order to verify the efficacy and safety of Nilotinib used in first line treatment, we collected the results of a real life cohort of Pts treated in some italian hematological Institutions. Patients and Methods 68 Pts affected by CML-CP were treated in 9 hematologic units with Nilotinib as first line therapy from 2010 to 2014. The median age was 47.7y with equal distribution by sex. Cytogenetic analysis at diagnosis showed in 66/68 Pts the presence of the typical Ph1 chromosome, 1 pt showed a Ph1 in a complex translocation and 1 pt showed the typical Ph1 chromosome plus der(17). The molecular analysis confirmed the presence of a BCR/ABL hybrid gene (55/68: b3a2 transcript; 12/68 b2a2 transcript; 1/68 both transcripts). The Sokal risk was: Low 24 Pts (35.3%), Intermediate 33 Pts (48.5%), High 11 Pts (16.2%); the Hasford risk was: Low 35 Pts (51.5%), Intermediate 27 Pts (39.7%), High 6 Pts (8.8%); the EUTOS risk was: Low 61 Pts (89.7%) and High 7 Pts (10.3%). All Pts have an ECOG 0/1 out of 1 with an ECOG 2. 45/68 pts received a cytoreduction by HU. All Pts received the Nilotinib standard dose of 600 mg/die except 1 pt who received 300 mg/die. At diagnosis some Pts showed comorbidities (21/68: hypertension; 6/68: diabetes; 5/68: dyslipidemia; 2/68: previous myocardial infarction; 1/68 was in treatment for HIV infection) Results 66/68 Pts received at least 3 months of treatment and were considered for analysis. At 3 months, all Pts obtained hematological response; cytogenetic response was complete for 65/68 and partial in 3/68. At 6, 12 and 18 months cytogenetic response was complete in all Pts except for 1 that showed a partial response (pt not compliant); at 24 mo the cytogenetic response was complete for all 25 evaluable Pts. The molecular results at the different time points are summarized in table 1. 6/68 Pts showed G1/G2 cutaneous side effects (pruritus, erithema, alopecia) , 6/68 a G1 increase of amylase and/or lipase, but only 1 developed clinical pancreatitis (at diagnosis: hypertension, hypercolesterolemia and cardiac disfunction). One pt underwent to leg amputation for PAOD (at diagnosis: hypertension and hypertriglyceridemia). He discontinued treatment in optimal response at 12mo. One pt had ischemic cerebral event (at diagnosis had hypertension and a previous heart attack). One pt discontinued treatment for pancitopenia in failure of response at 3mo and one pt died at 12mo in failure of response for IMF diagnosed during treatment. No pts developed mutations of BCR/ABL during treatment. In 24 months of observation no Pts lost the response. Conclusion The response to Nilotinib treatment at 3 months according to ELN revealed that all evaluable Pts were in optimal response; at 6 mo 51/55 (92,7 %) Pts were in optimal response, while at 12 mo 38/45 (86,7%) Pts were in optimal response. At 18 mo 94,1% reached at least MMR with a very deep response (MR>= 4) in 55,9% of Pts. This kind of response was mantained at 24 mo (92% of Pts had at least an MR3 and 15/25 had an MR 4). Notabily starting from 12 months, at least 40 % of pts showed a very deep response (MR >= 4) and the number increased at the subsequent time points. The side effects were few and of low grade. Only 3 Pts discontinued the treatment because side effects. Only a severe side effect (PAOD) was reported in a pt who already had a vascular risk because affected from hypertension and hypertriglyceridemia. It is recommended to check at diagnosis and carefully follow during the treatment for all comorbidities to prevent toxicity. These data collected in a real life treatment with Nilotinib in first line in CML -CP patients, confirmed the results of the clinical trials. The rapid and deep response with a tolerable toxicity profile allow to consider Nilotinib as a good choice for first line treatment also in consideration of a stop therapy in a future. Table 1 Time Pts MR1 MR2 MR3 MR4 MR4.5 MR5 (mo) (N) 3 60 10 31 13 4 2 - 6 55 4 16 20 4 11 - 12 45 1 6 20 4 13 1 18 34 0 2 13 6 12 1 24 25 0 2 8 6 8 1 Disclosures No relevant conflicts of interest to declare.
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Jimeno, María-Luisa, Ibon Alkorta, José Elguero, and Janet E. Del Bene. "Computed coupling constants in X(CH3)nH(4–n) moieties whereX =13C and15N+, andn = 0–4: comparisons with experimental data." Magnetic Resonance in Chemistry 44, no. 7 (2006): 698–707. http://dx.doi.org/10.1002/mrc.1840.
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Atkins, P. W. "M. Munowitz. Coherence and NMR. Wiley, Chichester, 1988, ISBN 0 471 61523 4, £27.10." Magnetic Resonance in Chemistry 27, no. 7 (1989): 710. http://dx.doi.org/10.1002/mrc.1260270723.
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Binotto, Gianni, Fausto Castagnetti, Gabriele Gugliotta, et al. "One Size Does Not Fit to All: Intolerant or Resistant CML Patients Could Benefit from Different Ponatinib Starting Dose Strategies. Multicenter Italian Experience." Blood 132, Supplement 1 (2018): 1732. http://dx.doi.org/10.1182/blood-2018-99-116825.
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Abstract Background: Ponatinib is effective as salvage treatment for chronic phase (CP) Ph+ chronic myeloid leukemia (CML) patients resistant or intolerant to prior TKIs. Based on the concern for an unfavourable cardiovascular toxicity profile, a dose reduction to 15 mg daily is currently recommended in CP patients after the achievement of treatment milestones. As more flexible approaches with TKIs dosage are increasingly adopted in clinical practice, identifying specific profiles of patients eligible for different treatment strategies, in order to improve the benefit/risk ratio, would be of particular interest. Aims: To update previous observations in an extended cohort of CML patients, resistant or intolerant to prior TKIs, describing the efficacy and toxicity of two different ponatinib schedules (de-escalated vs 15 mg starting dose). Secondly, to investigate whether specific subsets of CML patients were managed more successfully with one strategy. Methods: A retrospective analysis of CML-CP patients treated with ponatinib 15 mg, as starting or de-escalated dose has been performed. No pre-specified criteria to switch to ponatinib, to reduce or to start therapy with a lower dose were indicated. Cytogenetic and molecular responses were evaluated according to the ELN2013 recommendations. Toxicities under ponatinib treatment leading to transient or definitive discontinuation were recorded. Results: 68 patients were included in this analysis. Median age at ponatinib start was 57 years (range: 28-87). The median time from CML diagnosis to ponatinib treatment was 4.6 years (range: 0.4-19). Most patients (70.6%) were treated with imatinib as frontline treatment. 30/68 patients (44%) received ponatinib as 4th or subsequent line of therapy. ABL1 mutations were detected in 18 (26.5%) patients (being 44% of them positive for the T315I mutation). 50/68 (73.5%) of cases had less than MR2 at the time of ponatinib initiation, with one third exhibiting primary refractoriness to all prior treatments. Resistance to prior TKIs was the reason for switch in 85% of patients treated with higher doses of ponatinib, while 13/26 patients starting with 15 mg were purely intolerant or intolerant and resistant (p= 0.001). No other significant differences between the two groups were identified. MR2, MR3 and MR4/MR4.5 rates were 78.6%, 59.6% and 28.6% in 42 patients treated with the "de-escalated" approach, respectively. First step of dose reduction was decided after a median time of 3.1 months, with a subsequent decrease to 15 mg after a median of 10 months. Dose modifications were guided mostly by adverse events (73%) and, less frequently, to prevent toxicity and/or following response attainment (27%). Median duration of treatment was 27 months (range: 2-81), with 5/42 patients discontinuing ponatinib (1 cerebrovascular accident, 2 severe hematologic toxicities, two cases of resistance/progression). 4 deaths were registered, three after blast crisis and one for a fatal cardiovascular event. 26 patients started ponatinib 15 mg daily, with a median duration of treatment was 15 months (range: 2-58). MR2 was obtained in 77%, MR3 in 69.3% and MR4 in 46.2% of cases, respectively. MR3 or deeper responses were maintained in 80% of patients; 7/26 lost their best acquired response, with subsequent dose escalation to higher than 15 mg in 5/26 patients. Treatment discontinuation was necessary in 3 cases (1 coronary vasospasm-induced acute coronary syndrome, 2 muscle skeletal pain). Of note, patients with ABL mutations gained benefit only from the "de-escalated" approach, with response improvements in 10/14 of cases vs 0/4 in the "low dose" group. Similarly, a higher rate of at least a MR2 was obtained in primary refractory patients treated ab initio with higher doses of ponatinib (57.1 % vs 14.3 %). However, focusing only on pure intolerant patients, 15 mg starting dose was very effective, with all patients achieving at least a MR3 or deeper response. Summary/Conclusion: With the limits of the retrospective nature and small sample size, these data suggest that different dose strategies could be applied to specific subsets of CP-CML patients. While mutations or refractoriness to previous treatments should address towards a "debulking approach" with 45 or 30 mg ponatinib dose, intolerant or "low level resistance" cases could benefit from lower starting dose. Further investigation in larger prospective trials is warranted. Disclosures Castagnetti: Incyte: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Bristol Meyers Squibb: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Gugliotta:Bristol-Myers Squibb: Honoraria; Incyte: Honoraria; Novartis: Honoraria; Pfizer: Honoraria. Abruzzese:Ariad: Consultancy; BMS: Consultancy; Novartis: Consultancy; Pfizer: Consultancy. Breccia:Pfizer: Honoraria; BMS: Honoraria; Novartis: Honoraria; Incyte: Honoraria. Levato:Novartis: Other: Advisory board. Pane:AMGEN: Speakers Bureau; BMS: Speakers Bureau; Novartis: Research Funding, Speakers Bureau.
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Lu, X. Y., D. Yi, and H. Chen. "Effect of MgO and Ag2O Mix-Additions on the Formation and Superconducting Properties of Bi-2223 Phase." Advanced Materials Research 1096 (April 2015): 251–55. http://dx.doi.org/10.4028/www.scientific.net/amr.1096.251.
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The bulk samples with the composition Bi1.8Pb0.4Sr1.9Ca2.1Cu3.5Oy + x wt% MgO + (5-x) wt% Ag2O (x = 0, 1, 2, 3, 4 and 5) were prepared by sintering at 840°C for 240 h after partialmelting at 870°C for 1 h. The sample with individual Ag2O addition shows the lowest melting temperature and the lowest proportion of the Bi-2223 phase, whereas the sample with individual MgO addition shows the highest melting temperature. The highest proportion of the Bi-2223 phase appears in the sample with 1wt% MgO and 4 wt%Ag2O mix-additions. With increasing MgO content, the width of hysteresis loop ΔM of the bulk samples at 77 K increases (0≦x≦2), and then decreases (2≦x≦5). The largest ΔM appears in the sample with 2 wt% MgO and 3 wt% Ag2O mix-additions.
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Zhou, Di, Jing Li, Li-Xia Pang, Da-Wei Wang, and Ian M. Reaney. "Novel water insoluble (NaxAg2−x)MoO4 (0 ≤ x ≤ 2) microwave dielectric ceramics with spinel structure sintered at 410 degrees." Journal of Materials Chemistry C 5, no. 24 (2017): 6086–91. http://dx.doi.org/10.1039/c7tc01718a.
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A novel series of spinel structured ultra-low temperature co-fired microwave dielectric (Na,Ag)MoO<sub>4</sub> ceramics were studied in detail. The (Na<sub>1.2</sub>Ag<sub>0.8</sub>)MoO<sub>4</sub> ceramic can be well sintered at 410 °C with a permittivity ∼8.1, a quality factor (Qf) ∼44 800 GHz and grain size 1–5 μm.
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Friedl, Stefan, and Stefano Vidussi. "Symplectic ${\bf 4}$–manifolds with $K = 0$ and the Lubotzky alternative." Mathematical Research Letters 18, no. 3 (2011): 513–19. http://dx.doi.org/10.4310/mrl.2011.v18.n3.a11.
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Hanf, Schirin, Toni Grell, Jessica E. Waters, Raúl García-Rodríguez, Evamarie Hey-Hawkins, and Dominic S. Wright. "Facile synthesis of a nickel(0) phosphine complex at ambient temperature." Chemical Communications 56, no. 57 (2020): 7893–96. http://dx.doi.org/10.1039/d0cc02142c.
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The reaction of the bis(methoxy)-2-pyridyl-phosphine (MeO)<sub>2</sub>P(2-py) with [Ni(MeCN)<sub>6</sub>](BF<sub>4</sub>)<sub>2</sub> leads to the unexpected, single-step reduction of Ni<sup>II</sup> and the formation of a tetrahedral nickel(0) complex.
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Shijie, Zhu, Junji Moriya, Jun’ichi Yamakawa та ін. "Mao-to Prolongs the Survival of and Reduces TNF-α Expression in Mice with Viral Myocarditis". Evidence-Based Complementary and Alternative Medicine 7, № 3 (2010): 341–49. http://dx.doi.org/10.1093/ecam/nen010.
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Goal of this study was to evaluate effects of Mao-to on development of myocarditis induced by encephalomyocarditis (EMC) virus in mice. Mice were randomly divided into five groups. Group N included uninfected controls (n= 18), while group A, B and C underwent intraperitoneal injection of EMC virus. Group A was administered oral saline from day 0 to day 4. Group B was administered oral Mao-to (500 mg−1kg−1day−1) from day 0 to day 4. Group C was administered Mao-to from day 2 to day 6. Group D was administered Mao-to from day 5 to day 10. Treated mice were followed for survival rates during 2 weeks after infection. Body weight (BW) and organ weights including heart (HW), lungs, thymus and spleen were examined on days 4, 6 and 14. Survival rate of group C (36.4%) was significantly improved compared with group A, B or D (0% of each,P< 0.05). HW and HW/BW ratio in group C was significantly (P< 0.05) lower than those in group A, B or D. Viral titers of hearts were significantly different among groups A, B and C. Cardiac expression in tumor necrosis factor-α (TNF-α) was significantly reduced in group C in comparison with group A, B or D on day 6 by immunohistochemical study. Administration of Mao-to starting on day 2 improves mortality resulting from viral myocarditis in mice with reduced expression of cardiac TNF-α. These findings suggest that timing of Mao-to is crucial for preventing cardiac damage in mice with viral myocarditis.
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Wang, Jian Sheng, Zhi Fa Wang, Jing Long Bu, and Jun Xing Chen. "Effect of Ferric Oxide Addition on the Performance of MgO-Al2O3 System Materials." Advanced Materials Research 399-401 (November 2011): 805–8. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.805.
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The MgO-Al2O3 system materials were prepared at 1600°C for 3h with magnesia powder and alumina powder as raw materials and with ferric oxide powder as additive. The effect of the ferric oxide additive on the sintering and thermal shock resistance of the composite materials was studied. The results showed that increasing the ferric oxide dosage could improve the densification of the MgO-Al2O3 system materials. In sample MAF-0, crystal phases all are spinel phase. With the ferric oxide dosage increased from 2% to 6% in MAF-2, MAF-4 and MAF-6, the MgAl2O4 (spinel) became the primary crystal phases, and less amount of sosoloid 20MgO•19Al2O3•Fe2O3. In comparison with samples MAF-0, MAF-2, MAF-6, sample MAF-4 has better structure compactness and thermal shock resistance, the optimum ferric oxide dosage was added in MgO-Al2O3 system material is equal to 4%. The MgO-Al2O3 system material is acceptable for application in cement rotary kiln linings and high temperature gas filter support.
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Zhukovskii, Yuri F., Eugene A. Kotomin, David Fuks, Simon Dorfman, and Alex Gordon. "Hartree–Fock study of adhesion and charge redistribution on the Ag/MgO(0 0 1) interface." Surface Science 482-485 (June 2001): 66–72. http://dx.doi.org/10.1016/s0039-6028(00)01010-4.
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Klose, G., F. Volke, G. Peinel, and G. Knobloch. "199Hg NMR of aqueous solutions of inorganic mercury salts. Chemical shifts of HgCl2 −n withn = 0-4." Magnetic Resonance in Chemistry 31, no. 6 (1993): 548–51. http://dx.doi.org/10.1002/mrc.1260310606.
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Khan, M. A., D. J. Harris, and S. C. Parker. "Atomistic simulation of the effect of impurities on vacancy migration at the {4 1 0}/[0 0 1] tilt grain boundary of MgO." Physics and Chemistry of Minerals 27, no. 2 (1999): 133–37. http://dx.doi.org/10.1007/s002690050249.
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ARDELEAN, I., IOANA TODOR, P. PĂŞCUŢĂA, and I. BRATU. "IR STRUCTURAL INVESTIGATION OF Bi2O3 · GeO2 GLASSES CONTAINING MANGANESE IONS." Modern Physics Letters B 17, no. 08 (2003): 311–15. http://dx.doi.org/10.1142/s0217984903005342.
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Glasses from the x MnO · (100-x)[ Bi2O3 · GeO2 ] system, with 0≤ x ≤ 50 mol%, have been obtained and characterized by IR spectroscopy in order to obtain information about the influence of MnO on the local structure of the Bi 2 O 3 · GeO 2 glass matrix. The presence and the dependence of the structural units BiO 3, BiO 6 and GeO 4 on the MnO content was analyzed.
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CURRIE, A., L. MACDOUGALL, J. ARAMINI, C. GAULIN, R. AHMED, and S. ISAACS. "Frozen chicken nuggets and strips and eggs are leading risk factors for Salmonella Heidelberg infections in Canada." Epidemiology and Infection 133, no. 5 (2005): 809–16. http://dx.doi.org/10.1017/s0950268805004383.
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A case-control study was conducted from 1 January to 31 May 2003 to identify risk factors for S. Heidelberg infection in Canada. Controls were pair-matched by age group and telephone exchange to 95 cases. Exposures in the 7 days before illness/interview were assessed using multivariate conditional logistic regression. Consumption of home-prepared chicken nuggets and/or strips [matched odds ratio (mOR) 4·0, 95% confidence interval (CI) 1·4–13·8], and undercooked eggs (mOR 7·5, 95% CI 1·5–75·5) increased the risk of illness. Exposure to a farm setting lowered the risk (mOR 0·22, 95% CI 0·03–1·00). The population-attributable fraction associated with chicken nuggets/strips was 34% and with undercooked eggs was 16%. One-third of study participants did not perceive, handle or prepare chicken nuggets and strips as high-risk products, although the majority of the products on the Canadian market are raw. These findings have prompted changes in product-labelling policy and consumer education.
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Qin, Dan, and Wanjun Tang. "Energy transfer and multicolor emission in single-phase Na5Ln(WO4)4−z(MoO4)z:Tb3+,Eu3+ (Ln = La, Y, Gd) phosphors." RSC Advances 6, no. 51 (2016): 45376–85. http://dx.doi.org/10.1039/c6ra10763j.
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A series of Tb<sup>3+</sup> and/or Eu<sup>3+</sup>-doped Na<sub>5</sub>Ln(WO<sub>4</sub>)<sub>4−z</sub>(MoO<sub>4</sub>)<sub>z</sub> (0 ≤ z ≤ 4, Ln = La, Y, Gd) phosphors have been prepared via a simple Pechini method.
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Morozov, Vladimir A., Svetlana M. Posokhova, Dina V. Deyneko, et al. "Influence of annealing conditions on the structure and luminescence properties of KGd1−xEux(MoO4)2 (0 ≤ x ≤ 1)." CrystEngComm 21, no. 42 (2019): 6460–71. http://dx.doi.org/10.1039/c9ce01244c.
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Prager, M., M. Havighorst, G. Coddens, and H. Büttner. "Rotational tunnelling and structural phase transitions of NH3 adsorbed as a submonolayer on MgO{1 0 0} surfaces." Physica B: Condensed Matter 234-236 (June 1997): 170–72. http://dx.doi.org/10.1016/s0921-4526(96)00940-4.
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Senthilkumaran, B., and K. P. Joy. "Effects of ovariectomy and oestradiol replacement on hypothalamic serotonergic and monoamine oxidase activity in the catfish, Heteropneustes fossilis: a study correlating plasma oestradiol and gonadotrophin levels." Journal of Endocrinology 142, no. 2 (1994): 193–203. http://dx.doi.org/10.1677/joe.0.1420193.
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Abstract Hypothalamic serotonin (5-HT; content and turnover) and monoamine oxidase (MAO) activity were measured in female catfish, Heteropneustes fossilis, after ovariectomy and supplementation with oestradiol-17β (OE2) in the recrudescent and quiescent phases. These factors were correlated with changes in plasma levels of OE2 and gonadotrophin. In the quiescent phase (December), neither ovariectomy nor OE2 supplementation had any significant effect on 5-HT content and MAO activity. Plasma levels of OE2 and gonadotrophin were undetectable in both control and treated fish, indicating that there was no feedback effect. In the recrudescent phase (prespawning, May), ovariectomy caused biphasic responses of MAO activity and 5-HT content. The enzyme activity decreased significantly after 2, 3, 4 and 5 weeks but increased significantly 6 weeks after ovariectomy. The 5-HT content varied in a biphasic manner with a significant increase at 2, 3 or 4 weeks and a significant decrease in week 6; there being no effect in week 5. 5-HT turnover was inhibited significantly only in week 4 after ovariectomy and did not show a biphasic pattern. In the ovariectomized groups, the OE2 level decreased significantly in a progressive manner with a maximum reduction in week 6. The plasma level of gonadotrophin showed a significant bimodal pattern of increase with the peak in week 4 after ovariectomy, indicating a strong negative feedback effect of OE2. The bimodal pattern of pituitary gonadotrophin release could be correlated with a similar pattern of increase in 5-HT content. OE2 treatment of fish which had been ovariectomized 3 weeks previously had dose-dependent effects on the enzyme; the low dose (0·1 μg/g body weight) was stimulatory and the higher doses (0·5, 1·0 and 5·0 μg/g body weight) were inhibitory. The reverse was true for 5-HT content. Serotonergic turnover increased significantly only in the groups given high doses (1·0 and 5·0 μg/g body weight). The low dose of OE2 (0·1 μg/g body weight) restored the gonadotrophin and OE2 levels to those of the sham-ovariectomized vehicle-treated control group, whereas the high doses (0·5, 1·0 and 5·0 μg/g body weight) decreased the release of gonadotrophin in a dose-dependent manner. Our results suggest that OE2 modulates MAO activity to alter hypothalamic 5-HT in a seasonally dependent manner. The ovariectomy-induced changes in plasma levels of gonadotrophin appear to be mediated, at least partly, by the feedback action of OE2 on 5-HT metabolism. Journal of Endocrinology (1994) 142, 193–203
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Mohammed, Gh, та S. El-Gamal. "The role of MgO nanoparticles addition, and γ-irradiation on the microstructural, and tensile properties of Al-1100 alloy". Journal of Composite Materials 55, № 16 (2021): 2135–49. http://dx.doi.org/10.1177/0021998320983411.
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Aluminum matrix composites (AMCs) are innovative engineering materials in which a tough reinforcement is included in the aluminum matrix to improve its properties. In the study, MgO (0–4 wt.%) was loaded to Al-1100. The XRD reveals that MgO has a cubic crystal structure, purity of 100 %, and the average crystallite size is 17.4 nm, from Scherer's formula. HR-TEM reflected that MgO displays nanoparticle-like morphology. The microstructural properties of AMCs manifested the intermetallic compounds’ absence, grain refinement, good MgO distribution, and the presence of few porosities. The density measurement confirmed the decrease in the experimental density with increasing MgO while the theoretical density increased. The maximum porosity found is 1.4 % which is accepted in the fabrication of AMCs. The tensile properties revealed that as the strain rate ([Formula: see text]), γ-irradiation dose, and MgO content increases, the fracture stress ([Formula: see text]) increases while the ductility (εΤ) decreases. These three parameters could control the tensile properties of AMCs reinforced with MgO as well. An improvement by 140 % in σf was achieved for AMC with 4 wt.% MgO (at [Formula: see text] = 1.2 × 10−3 s−1, 2 MGy) compared to plain Al-1100 alloy (at [Formula: see text] = 5.4 × 10−5 s−1, 0 Gy). It was suggested that the load transfer from matrix to reinforcement was efficient which directly improves the load-carrying ability of these synthesized AMCs. Several mechanisms such as Orowan strengthening, and dislocation strengthening, were suggested to interpret the tensile properties.
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WU, M. S., H. C. I. KAO, H. S. SHEU, et al. "STRUCTURE AND PROPERTIES OF (La2-xSrx)MnO4 COMPOUNDS." International Journal of Modern Physics B 19, no. 01n03 (2005): 541–48. http://dx.doi.org/10.1142/s0217979205029006.
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Polycrystalline single phase ( La 2-x Sr x) MnO 4 (1.10≤ x ≤1.40) samples were prepared by a citrate precursor method. They have tetragonal K 2 NiF 4 structure with a space group of 14/mmm, increasing x, unit-cell a-axis increases and c-axis decreases, which is a result of decreasing of the Jahn-Teller effect due to the increase of the Mn ( IV ) ion. Spin glass state exists at low temperature and a hump observed from the susceptibility (χ) measurement is probably caused by the interactions of several magnetic phases. Among them, ( La 0.6 Sr 1.4) MnO 4 has the largest magnetoresistance ratio ([ρ(H)-ρ(0)]/ρ(0)), which reaches to 78.4% at 48 K. It is not possible to obtain single phase materials with 0.60≤ x ≤1.00 in the heat treatment temperature range of 1000-1600°C. Impurities were easily observed under SEM and X-ray diffraction patterns. Increasing the heating period and decreasing the temperature, the amount of ABO3 perovskite phase increases. In order to extend the solubility range, of the SrO in the ( La 2-x Sr x) MnO 4, it probably needs a higher temperature (>1600°C) and a shorter heat treatment period (<1 h).
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Aratani, Yasuaki, Fumiaki Kura, Haruo Watanabe, et al. "Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans." Journal of Medical Microbiology 55, no. 9 (2006): 1291–99. http://dx.doi.org/10.1099/jmm.0.46620-0.
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The in vivo contribution of reactive oxygen species produced by neutrophils against Cryptococcus infection is not widely recognized. Myeloperoxidase (MPO) is a neutrophil-specific enzyme that catalyses the production of hypohalous acids such as HOCl from H2O2. This study investigated the role of MPO in immunological defence against Cryptococcus neoformans in an MPO-deficient (MPO−/−) mouse model. The survival of MPO−/− mice infected either intranasally or intravenously with C. neoformans was lower than that of identically challenged wild-type mice. The MPO−/− mice that received intranasal injection of C. neoformans had significantly larger lung fungal burdens than wild-type mice. On day 7, MPO−/− mice had a significantly higher lung concentration of interleukin (IL)-4 and lower concentrations of IL-2, IL-12p70 and interferon (IFN)-γ than wild-type mice, suggesting a weak Th1 response in the MPO−/− mice to C. neoformans. Pathologically, the MPO−/− mice with intranasal infection showed more severe pneumonia than wild-type mice, which was associated with an increase in the levels of IL-1α/β in the lungs. In addition, in MPO−/− mice, the pulmonary infection disseminated to the brain with occasional meningitis. The keratinocyte-derived cytokine (KC) level in the brain of infected MPO−/− mice was higher than that of control mice. Both intranasal and intravenous infections resulted in a higher number of fungi in the spleen of MPO−/− mice compared to wild-type, suggesting decreased resistance to C. neoformans not only in the lungs but also in the spleen in the absence of MPO. Taken together, these data suggest a major role of MPO in the response to cryptococcal infection.
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Awad, Abbas Y., Mohammed N. Ibrahim, and Mohamed K. Hussein. "Effects of Rice Husk Ash–Magnesium Oxide Addition on Wear Behavior of Aluminum Alloy Matrix Hybrid Composites." Tikrit Journal of Engineering Sciences 25, no. 4 (2018): 15–22. http://dx.doi.org/10.25130/tjes.25.4.04.
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A336.0 aluminum alloy used to fabricate hybrid composites using rice husk ash (RHA) and MgO particles as reinforcement. The influence of the particles on the wear behavior of A336.0 aluminum alloy as a matrix that reinforced with MgO and RHA was investigated. Firstly, the rice husk burned at 700°C and then heat treated at 1100°C for 2 hrs. The ash characterized by X-ray florescence and X-ray diffraction. Less than 53 and 125 micron are the particle sizes of MgO and RHA respectively. The hybrid composites manufactured using stir casting method in two steps. A336.0 aluminum alloy reinforced with 4:0, 3:1, 2:2, 1:3 and 0:4 of RHA: MgO with 10 wt% total reinforcement phase. Optical microscope and X-ray diffraction were used to characterize the prepared hybrid composites. Dry sliding wear, hardness, apparent density, percentage of porosity and coefficient of friction were examined. Results indicated that porosity, apparent density and hardness enhanced with increasing MgO, while increasing wt% of RHA decreased the apparent density. Results indicated that with inceasing the applied load the wear rate of the composites was enhanced. Coefficient of friction varies inversely with applied load and wt% of RHA. Hardness increased with increasing RHA while the friction coefficient and the wear rate decreased. The minimum wear rates were at 10% RHA and Al-alloy-(RHA-MgO) [3:1] composites, while the minimum friction coefficients were at 10% RHA composites.
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WINTER, C. H., S. O. BROCKMANN, I. PIECHOTOWSKI, et al. "Survey and case-control study during epidemics of Puumala virus infection." Epidemiology and Infection 137, no. 10 (2009): 1479–85. http://dx.doi.org/10.1017/s0950268809002271.
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SUMMARYIn Baden-Wuerttemberg, a federal state in south-west Germany, a large outbreak of 1089 laboratory-confirmed human Puumala virus (PUUV) infections occurred in 2007. We conducted a survey to describe the disease burden and a case-control study to identify risk factors for acquiring PUUV. Case-patients were interviewed about clinical outcome and both case-patients and randomly recruited controls were interviewed about exposure. We calculated matched odds ratios (mOR) using a conditional logistic regression model. Multivariable analysis of 191 matched case-control pairs showed that case-patients were more likely than controls to have seen small rodents/their droppings (mOR 1·9, 95% CI 1·2–3·0), cleaned utility rooms (mOR 1·8, 95% CI 1·0–3·4) and visited forest shelters (mOR 3·9, 95% CI 1·1–14·3). Two thirds of case-patients required hospitalization. During PUUV epidemics rodent control measures and use of protective equipment should be considered in utility rooms and shelters.
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MANSOUR, A. M., H. EL MOHAMMADY, M. EL SHABRAWI, et al. "Modifiable diarrhoea risk factors in Egyptian children aged <5 years." Epidemiology and Infection 141, no. 12 (2013): 2547–59. http://dx.doi.org/10.1017/s0950268813000319.
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SUMMARYBy conducting a case-control study in two university hospitals, we explored the association between modifiable risk behaviours and diarrhoea. Children aged <5 years attending outpatient clinics for diarrhoea were matched by age and sex with controls. Data were collected on family demographics, socioeconomic indicators, and risk behaviour practices. Two rectal swabs and a stool specimen were collected from cases and controls. Samples were cultured for bacterial pathogens using standard techniques and tested by ELISA to detect rotavirus andCryptosporidiumspp. Four hundred cases and controls were enrolled between 2007 and 2009. The strongest independent risk factors for diarrhoea were: presence of another household member with diarrhoea [matched odds ratio (mOR) 4·9, 95% CI 2·8–8·4] in the week preceding the survey, introduction to a new kind of food (mOR 3, 95% CI 1·7–5·4), and the child being cared for outside home (mOR 2·6, 95% CI 1·3–5·2). While these risk factors are not identifiable, in some age groups more easily modifiable risk factors were identified including: having no soap for handwashing (mOR 6·3, 95% CI 1·2–33·9) for children aged 7–12 months, and pacifier use (mOR 1·9, 95% CI 1·0–3·5) in children aged 0–6 months. In total, the findings of this study suggest that community-based interventions to improve practices related to sanitation and hygiene, handwashing and food could be utilized to reduce the burden of diarrhoea in Egyptian children aged <5 years.
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Guo, Jing, Di Zhou, Yong Li, et al. "Structure–property relationships of novel microwave dielectric ceramics with low sintering temperatures: (Na0.5xBi0.5xCa1−x)MoO4." Dalton Trans. 43, no. 31 (2014): 11888–96. http://dx.doi.org/10.1039/c4dt00838c.
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A series of low firing microwave dielectric ceramics (Na<sub>0.5x</sub>Bi<sub>0.5x</sub>Ca<sub>1−x</sub>)MoO<sub>4</sub> (0 ≤ x ≤ 0.6) was synthesized and their structure–property relationships were investigated.
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Rauser, P., P. Janalik, M. Markova, and T. Fichtel. "Early analgesia after periodontal treatment in dogs: a comparison of three analgesic protocols." Veterinární Medicína 58, No. 6 (2013): 312–17. http://dx.doi.org/10.17221/6867-vetmed.
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The analgesic effects of carprofen, morphine and bupivacaine on early oral pain after periodontal treatment in dogs have been poorly investigated. Forty-five client-owned dogs (8.5 &plusmn; 6.4 kg and 7.8 &plusmn; 3.2 years) scheduled for periodontal treatment were allocated to carprofen, morphine and bupivacaine groups (n = 15 each). The study was designed as a prospective, randomised, double &ldquo;blinded&rdquo; clinical study. Carprofen (CAR, 4 mg/kg, subcutaneously) or morphine (MOR, 0.3 mg/kg, intramuscularly) was given thirty minutes before the dogs were placed under anesthesia. Bilateral maxillary and mandibular nerve blocks were performed with bupivacaine (BUP, 1 mg/kg), after the induction of anesthesia. Dogs were anaesthetised with medetomidine-propofol-isoflurane and reversal was carried out using atipamezole. Periodontal painful sub-gingival scaling was performed in all dogs. Periodontal treatment lasted for up to one hour. A modified University of Melbourne Pain Score (UMPS, 0&ndash;28&nbsp;points), Visual Analog pain Scale (VAS, 0&ndash;100 mm), plasma glucose (Glu) and serum cortisol (Cor) levels were assessed before administration of analgesics (MOR-0, CAR-0, BUP-0) and two hours thereafter, that is thirty minutes after atipamezole administration (MOR-2, CAR-2, BUP-2). Analgesia rescue with tramadol (2 mg/kg intramuscularly) was provided for animals with modified UMPS over 14 or VAS over 50 points. Differences in Glu and Cor values were analysed with analysis of variance (ANOVA) for repeated measures, in UMPS and VAS over time for each group with the Friedman test and pre- and postoperatively using the Mann-Whitney U-test. Differences were considered significant at P &lt; 0.05. Analgesia rescue was provided to one patient of the CAR group and one patient of the MOR group. No differences in UMPS values between groups were detected. A significant increase in VAS values after treatment was detected in all groups. Plasma glucose levels significantly increased in MOR-2 compared to MOR-0 and CAR-2. Serum cortisol levels significantly increased in MOR-2 compared to MOR-0, CAR-2 and BUP-2. The results of this study indicate that bupivacaine nerve blocks could be superior to carprofen, which in turn could be superior to morphine, for early analgesia (up to two hours) following sub-gingival scaling for periodontal treatment in dogs. &nbsp;
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Li, Zhenhua, Yanping Li, Barrie Bonsal, Alan H. Manson, and Lucia Scaff. "Combined impacts of ENSO and MJO on the 2015 growing season drought on the Canadian Prairies." Hydrology and Earth System Sciences 22, no. 10 (2018): 5057–67. http://dx.doi.org/10.5194/hess-22-5057-2018.
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Abstract. Warm-season precipitation on the Canadian Prairies plays a crucial role in agricultural production. This research investigates how the early summer 2015 drought across the Canadian Prairies is related to the tropical Pacific forcing. The significant deficit of precipitation in May and June 2015 coincided with a warm phase of the El Niño–Southern Oscillation (ENSO) and a negative phase of Madden–Julian Oscillation (MJO)-4 index, which favour a positive geopotential height (GPH) anomaly in western Canada. Our further investigation during the instrumental record (1979–2016) shows that warm-season precipitation in the Canadian Prairies and the corresponding atmospheric circulation anomalies over western Canada teleconnected with the lower boundary conditions in the tropical western Pacific. Our results indicate that MJO can play a crucial role in determining the summer precipitation anomaly in the western Canadian Prairies when the equatorial central Pacific is warmer than normal (NINO4 > 0) and MJO is more active. This teleconnection is due to the propagation of a stationary Rossby wave that is generated in the MJO-4 index region. When the tropical convection around MJO-4 index region (western tropical Pacific, centred over 140∘ E) is more active than normal (NINO4 > 0), Rossby wave trains originate from the western Pacific with wavenumbers determined by the background mean wind and meridional absolute vorticity gradient. Under warm NINO4 conditions waves are generated with smaller wavenumbers compared to cold NINO4 conditions. These waves under warm NINO4 can propagate into the mid-latitudes over North America, causing a persistent anomalous ridge in the upper level over western Canada, which favours dry conditions over the region.
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Sulistiardi, Herdyka, Dani Gustaman Syarif, and Endi Suhendi. "PENGARUH WAKTU POSTSINTERING HEAT TREATMENT (PHT) PADA KONDUKTIVITAS IONIK ELEKTROLIT PADAT CALCIA STABILIZED ZIRCONIA (CSZ) YANG MENGANDUNG SILICA (SiO2) DAN MAGNESIA (MgO)." Jurnal Sains dan Teknologi Nuklir Indonesia 17, no. 1 (2016): 11. http://dx.doi.org/10.17146/jstni.2016.17.1.2275.
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PENGARUH WAKTU POSTSINTERING HEAT TREATMENT (PHT) PADA KONDUKTIVITAS IONIK ELEKTROLIT PADAT CALCIA STABILIZED ZIRCONIA (CSZ) YANG MENGANDUNG SILICA (SiO2) DAN MAGNESIA (MgO). Pengaruh waktu Postsintering Heat Treatment (PHT) pada konduktivitas ionik elektrolit padat CSZ yang mengandung SiO2 dan MgO telah diteliti. PHT dilakukan dengan tujuan untuk meningkatkan konduktivitas ionik elektrolit padat CSZ yang mengandung SiO2 dan MgO. Elektrolit padat CSZ yang mengandung SiO2 dan MgO dibuat menggunakan metode pressing dengan komposisi CSZ, SiO2, dan MgO berturut-turut 99 %berat, 0,5 %berat, dan 0,5 %berat. Pelet kemudian disinter pada suhu 1450ᵒC selama 4 jam dan PHT pada suhu 1350ᵒC dengan variasi waktu 0 jam, 4 jam, dan 8 jam. Analisis struktur kristal menunjukkan bahwa pelet yang telah dibuat membentuk kristal kubik dan tidak terpengaruh PHT. Analisis densitas menunjukkan bahwa terjadi peningkatan densitas seiring peningkatan waktu PHT tetapi peningkatan tersebut tidak begitu signifikan. Analisis struktur mikro menunjukkan bahwa tidak terdapat perbedaan ukuran butir yang signifikan seiring peningkatan waktu PHT, namun terjadi perubahan distribusi pori. Berdasarkan penelitian yang telah dilakukan diketahui bahwa seiring peningkatan waktu PHT terjadi pula peningkatan konduktivitas ionik elektrolit padat CSZ yang mengandung SiO2 dan MgO.
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Venkatram, Mamtha, Hebbale Narayana Rao Narasimha Murthy, Anand Gaikwad, Sham Aan Mankunipoyil, Sridhar Ramakrishna, and Phani Ayalasomayajula Ratna. "Antibacterial and Flame Retardant Properties of Ag-MgO/Nylon 6 Electrospun Nanofibers for Protective Applications." Clothing and Textiles Research Journal 36, no. 4 (2018): 296–309. http://dx.doi.org/10.1177/0887302x18783071.
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Electrospun nanofibers are researched for protective applications. Ag nanoparticles promote antibacterial properties and MgO enhances fire retardancy. The main objective of this research was to develop Ag/MgO/Nylon 6 electrospun nanofibers that are scarcely reported. Nanofibers were synthesized using formic acid and acetic acid solvents and collected on cotton fabric. Nylon 6 in 20 wt% along with MgO in 3–5 wt% and AgNO3 in 0.25–0.75 wt% was used for electrospinning. Nanofibers of diameter 35–55 nm with no beads were obtained for MgO (5%)–AgNO3 (0.5%)/Nylon 6. Bacterial reduction of 88% for MgO (3%)–AgNO3(0.25%)/Nylon 6 against Staphylococcus aureus bacteria and 54% against Escherichia coli was achieved. Nanofibers of MgO (3%)–AgNO3 (0.25%)/Nylon 6 and MgO (4%)–AgNO3 (0.5%)/Nylon 6 were rated V-0 in vertical burning test. Least burning rate of 1.56 mm/s corresponded to nanofibers of MgO (3%)–AgNO3 (0.25%)/Nylon 6 in horizontal burning test. Energy Dispersive X ray (EDX) confirmed the presence of Mg, O, and Ag. Fourier Transfer Infrared Spectroscopy (FTIR), the stretching of O–H and CH2.
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David Edison Tarigan, Eneng Hasanah, Dani Gustman Syarif,. "PENGARUH DOPING MgO TERHADAP KONDUKTIVITAS IONIK KERAMIK CSZ UNTUK ELEKTROLIT PADAT SOFC." GANENDRA Majalah IPTEK Nuklir 18, no. 2 (2015): 69. http://dx.doi.org/10.17146/gnd.2015.18.2.2653.
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ABSTRAK PENGARUH DOPING MgO TERHADAP KONDUKTIVITAS IONIK KERAMIK CSZ UNTUK ELEKTROLIT PADAT SOFC. Telah dilakukan pembuatan elektrolit padat untuk Solid Oxide Fuel Cell (SOFC). Elektrolit padat SOFC dibuat dari bahan Calcia Stabilized Zirconia (CSZ) yang didoping denganMagnesium Oxide. Konsentrasi dopingMagnesium Oxide dalam % berat adalah 0%; 0,1%, dan 0,3%. Setelah serbuk CSZ dan MgO dicampur dan digerus hingga homogen, serbuk campuran ditekan,yang diikuti dengan penyinteran pada suhu 14500C selama 4 jam. Impedansi keramik hasil sinter diukur dengan menggunakan LCRmeter untuk mengetahui konduktivitas ioniknya. Struktur kristal dianalisis dengan menggunakan X-Ray diffractometer (XRD) dan struktur mikro dianalisis dengan menggunakan Scanning Electron Microscope (SEM). Hasil analisis XRD menunjukkan bahwa elektrolit padat CSZ dan CSZ yang didoping MgO mempunyai struktur kubik. Hasil analisis SEM menunjukkan bahwa semakin besar konsentrasi MgO, semakin besar pula ukuran butir.Doping MgO dengan konsentrasi 0,3 % dapat meningkatkan konduktivitas ionik elektrolit padat CSZ dari 0,017 mS/cm menjadi 0,089 mS/cm.
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Anderson, Weston, Ángel G. Muñoz, Lisa Goddard, Walter Baethgen, and Xandre Chourio. "MJO teleconnections to crop growing seasons." Climate Dynamics 54, no. 3-4 (2020): 2203–19. http://dx.doi.org/10.1007/s00382-019-05109-0.
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AbstractWhile many Madden–Julian Oscillation (MJO) teleconnections are well documented, the significance of these teleconnections to agriculture is not well understood. Here we analyze how the MJO affects the climate during crop flowering seasons, when crops are particularly vulnerable to abiotic stress. Because the MJO is located in the tropics of the summer hemisphere and maize is a tropical, summer-grown crop, the MJO teleconnections to maize flowering seasons are stronger and more coherent than those to wheat, which tends to be grown in midlatitudes and flowers during the spring. The MJO significantly affects not only daily average precipitation and soil moisture, but also the probability of extreme precipitation, soil moisture and maximum temperatures during crop flowering seasons. The average influence on the probability of extreme daily precipitation, soil moisture, and maximum temperature events is roughly equal. On average the MJO modifies the probability of a 5th or 95th, 10th or 90th, and 25th or 75th percentile event by $$\sim $$∼ 2.5%, $$\sim $$∼ 4% and $$\sim $$∼ 7%, respectively. This means that an exceptionally dry (10th percentile) soil moisture value, for example, would become $$\sim $$∼ 40% more common (happening 14% of the time) during certain MJO phases. That the MJO can simultaneously dry soils and raise maximum air temperatures may be particularly damaging to crops because without available soil water during times of heat stress, plants are unable to transpire to cool leaf-level temperatures as a means of avoiding long-term damage. As a result, even though teleconnections from the MJO last only a few days to a week, they likely affect crop growth.
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XIA, H., W. XIAO, M. O. LAI, and L. LU. "IMPROVED CAPACITIVE BEHAVIOR OF MnO2 THIN FILMS PREPARED BY ELECTRODEPOSITION ON THE PT SUBSTRATE WITH A MnOx BUFFER LAYER." Functional Materials Letters 02, no. 01 (2009): 13–18. http://dx.doi.org/10.1142/s1793604709000478.
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Nanostructured MnO 2 thin films were prepared on two types of substrates, Pt / Ti / SiO 2/ Si (PT) and MnO x/ Pt / Ti / SiO 2/ Si ( MnO x/ PT ), by the technique of cyclic-voltammetric electrodeposition. The MnO x buffer layer was deposited on the PT substrate by pulsed laser deposition (PLD). The as-deposited MnO 2 thin films were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS). The electrochemical properties of the thin film MnO 2 electrodes were investigated using cyclic voltammetry (CV) in 1 M Na 2 SO 4 electrolyte. It was found that the adhesion between the MnO 2 film and the Pt substrate was poor, resulting in cracks and peeling of the MnO 2 film after deposition. However, the adhesion of the MnO 2 film with the MnO x buffer layer was greatly improved, resulting in superior pseudocapacitive performance of the thin film electrodes. A specific capacitance of about 364 F/g of MnO 2 thin films deposited on the MnO x buffer layer can be obtained at a scan rate of 10 mV/s in the voltage window between 0 and 0.9 V versus the Ag / AgCl reference electrode. The MnO 2 thin film deposited on the MnO x/ PT substrate exhibits good rate capability and excellent cycle performance, which makes it promising for supercapacitor application.
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Tomita, Kentaro, and Félix Arrúa Mancuello. "Rendimiento y absorción de macro nutrientes en el cultivo de zanahoria dancus carota. Var nantes, y lombricomposto en un suelo Entisol." Revista Alfa 2, no. 5 (2018): 90–100. http://dx.doi.org/10.33996/revistaalfa.v2i5.41.
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El cultivo de la zanahoria es uno de los rubros que potencialmente, ofrece alternativas y ventajas para ser producidas en fincas de pequeños productores. En el Departamento de Ñeembucú, la producción de esta hortaliza no alcanza a satisfacer las demandas locales. El objetivo de este estudio es determinar el manejo de la fertilidad del suelo Entisol cultivado con esta hortaliza para establecer un sistema sostenible de producción con bajos insumos. Se evaluaron 4 niveles del N (0, 50, 100 y 200kgN/ha) por 2 niveles del lombricomposto como M.O. (0 y 20t/ha) en el cultivo de zanahoria. La variedad utilizada fue Nantes. Al aplicar 20t/ha del lombricomposto (M.O.), se aplicaron 194kgN/ha, 228kgP2O5/ha, 50kgK2O/ha, 29kgCa/ha y 7.6kgMg/ha, respectivamente. Especialmente, se aplicó alto contenido del P2O5 en la superficie. No se observó diferencia estadísticamente significativa para materia orgánica del suelo en la mitad del ciclo del cultivo de zanahoria entre los tratamientos sin y con M.O. Los resultados de análisis de varianza, demuestra que hubo diferencia significativa al 1% para N y al 5% para M.O. en el rendimiento del tubérculo. En el tratamiento sin M.O., se observó alto rendimiento con 100kgN/ha, mientras que para el tratamiento con M.O. el de 50kgN/ha arrojo el más alto rendimiento. Sobre análisis de tejido vegetal, los resultados de análisis de varianza, demuestran que hubo diferencia significativa al 1% no sólo para N sino también para M.O. en la absorción del N, P y Mg en el tubérculo. Pero, se considera que hubo efecto diluido para la absorción del P en el tubérculo, teniendo en cuenta alto rendimiento observado en los tratamientos con M.O.
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Zhao, Yan, Yan Yan Wei, Dan Qin, et al. "Hydrothermal Synthesis and Photoluminescence Properties of Ca(MoO4)x(WO4)(1-X) Microcrystallines." Advanced Materials Research 652-654 (January 2013): 599–606. http://dx.doi.org/10.4028/www.scientific.net/amr.652-654.599.
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Ca(MoO4)x(WO4)(1-x)solid solution microcrystallines were synthesized by hydrothermal method at 120 °C; the crystal structure, surface morphology and room temperature photoluminescence properties of the as-synthesized microcrystallines were investigated by through X-ray diffraction (XRD), scanning electron micrograph (SEM), Fourier transform infrared spectroscopy (FT-IR) and fluorescence analysis (FA), respectively. Our results show that the obtained Ca(MoO4)x(WO4)(1-x)microcrystallines are single-phase scheelite structure with tetragonal symmetry. The grain size of the Ca(MoO4)x(WO4)(1-x) microcrystallines gradually increases with the increasing x (except x=0) and their agglomeration also becomes serious with x increasing. Under excited by 245 nm or 280 nm ultraviolet light (UV-light) at room temperature, the emission spectra of the Ca(MoO4)x(WO4)(1-x) microcrystallines vary slightly from 410nm to 490nm with increasing x. Whereas the emission intensity of Ca(MoO4)x(WO4)(1-x) microcrystallines changed markedly, and it increases with the increasing x (x＞0).
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Cooper, M. A., and F. C. Hawthorne. "The crystal structure of kraisslite,[4]Zn3(Mn, Mg)25(Fe3+,Al)(As3+O3)2[(Si,As5+)O4]10(OH)16, from the Sterling Hill mine, Ogdensburg, Sussex County, New Jersey, USA." Mineralogical Magazine 76, no. 7 (2012): 2819–36. http://dx.doi.org/10.1180/minmag.2012.076.7.13.
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AbstractThe crystal structure of kraisslite, orthorhombic (pseudo-hexagonal),a= 8.1821(1),b= 14.1946(3),c= 43.9103(8) Å,V= 5099.8(2) Å3,Z= 4 anddcalc= 4.083 g cm–3, has been solved by direct methods and refined in the space groupC2221to anR1index of 1.68% for 7432 observed (|Fo| > 4σ|F|) reflections. Electron-microprobe analysis gave the following chemical composition: As2O510.86, As2O36.18, SiO213.39, Al2O30.25, Fe2O32.06, MnO 51.14, ZnO 7.39, MgO 2.13, CaO 0.05, H2Ocalc= 4.50, sum 97.95 wt.%; and empirical formula: Zn2.91(Mn23.07Mg1.69Ca0.03)Σ=24.79(Fe0.833+Al0.16)Σ=0.99(As3+O3)2[(Si0.71As0.305+)O4]10(OH)16calculated on the basis of 62 anions with (OH) = 16 and As3+/(As3++ As5+) taken from the refined crystal structure. The general formula, [4]Zn3(Mn,Mg)25(Fe3+,Al)(As3+O3)2[(Si,As5+)O4]10(OH)16, differs from those given previously.There is one As3+site with a <As–O> distance of 1.780 Å and a stereochemistry typical of a stereoactive lone-pair of electrons. There are five tetrahedrally coordinated T sites with <T–O> distances from 1.635 to 1.692 Å; the T(1) site is fully occupied by As5+, and the T(2)–T(5) sites are occupied by both Si and As5+. There are two tetrahedrally coordinated Zn sites with <T–O> distances of ∼1.996 Å, both of which are occupied by dominant Zn and minor Mn2+. There are thirteen octahedrally coordinated M sites, twelve of which are occupied by dominant Mn2+with lesser Mg and minor Zn; <M–O> distances are in the range 2.197–2.284 Å. The <M(13)–O> distance is 2.083 Å and its lower site scattering indicates occupancy by Fe3+, Mn2+, Mg and Al. The structure consists of five crystallographically distinct layers of polyhedra, labelled m = 0 – 4. Layer m = 0 consists of corner-sharing Zn and (Si, As5+) tetrahedra, and layers m = 1–4 each consist of trimers of Mn2+octahedra linked by (Si, As5+) tetrahedra and intrasheet hydrogen bonds (m = 1, 3) or (Si, As5+) tetrahedra and (Fe3+,Al) octahedra (m = 2) or (As5+) tetrahedra and (As3+O3) triangular pyramids and intrasheet hydrogen bonds (m = 4). The layers stack along [001] with reversals of the sequence m = 1, 2, 3, 4 at z = 0, ¼, ½ and ¾. Kraisslite is a member of the mcgovernite family.
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Alajmi, Zafer, Tao Fu, Yan Tao Zhao, Shui Yun Yang, and Jia Mao Sun. "Ag-Enhanced Antibacterial Property of MgO Film." Materials Science Forum 859 (May 2016): 90–95. http://dx.doi.org/10.4028/www.scientific.net/msf.859.90.
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MgO and silver-containing MgO (AgMgO, 3.3, 9.1 at% Ag) films were sol-gel coated on titanium to improve its antibacterial property. Thermal analyses of MgAc2·4H2O powder revealed that MgO was crystallized at 400 °C. X-ray diffraction analysis showed that MgO was converted to Mg(OH)2 or Mg5(CO3)4(OH)2·4H2O during the ageing in air. Silver nanoparticles at the surface of AgMgO films were identified by scanning electron microscopy and x-ray photoelectron spectroscopy. The MgO film was about 1.5 um thick. The potentiodynamic polarization test in the Ca-free Hank’s balanced salt solution showed that the coated titanium samples had better corrosion resistance than the polished one. The dissolution of silver nanoparticles resulted in a current peak in the polarization plots. In the antibacterial test against E. Coli, the inhibition zone width was 0.3, 1.6, 2.0 mm for the films with 0, 3.3, 9.1 at% Ag, respectively. The bactericidal mechanisms of the MgO and AgMgO films were discussed. The present work would provide a facile method for antibacterial surface modification of titanium based osteo-implants.
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Kim-Ngan, N.-T. H., M. Krupska, A. G. Balogh, P. Malinsky, and A. Mackova. "High surface stability of magnetite on bi-layer Fe 3 O 4 /Fe/MgO(0 0 1) films under 1 MeV Kr + ion irradiation." Advances in Natural Sciences: Nanoscience and Nanotechnology 8, no. 4 (2017): 045005. http://dx.doi.org/10.1088/2043-6254/aa84e2.
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Nugroho, Estu, Rustadi Rustadi, Dwijo Priyanto, et al. "PENURUNAN KERAGAMAN GENETIK PADA F-4 IKAN NILA MERAH “CANGKRINGAN” HASIL PEMULIAAN DIDETEKSI DENGAN MARKER GENETIK." Jurnal Riset Akuakultur 9, no. 1 (2014): 25. http://dx.doi.org/10.15578/jra.9.1.2014.25-30.
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Variasi genetik ikan nila merah “Cangkringan” hasil pemuliaan dimonitor denganmenggunakan marker d-Loop DNA untuk mengetahui pembawa keragaman genetik yang dihasilkan karena kegiatan seleksi. DNA diekstraksi dari sirip ikan nila generasi 1 (F-0) hingga generasi ke-5 (F-4) dan diamplifikasi daerah d-Loop pada mitokondria menggunakan primer LH 1509 dan FH 1202. Secara statistik tidak terdapat perbedaan genotipe yang nyata antara ke-5 generasi ikan nila yang diuji. Terdapat penurunan variasi genetik dan kehilangan haplotipe sebesar 25% dari generasi pertama ke generasi 5 akibat seleksi berdasarkan komposite haplotipe dengan empat enzim restriksi Mbo-I, Hae-III, Rsa-I, dan Alu-I.
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Wang, Wei, Hang Zhou, Jian Li, et al. "Influence of Carbonization Process on the Mechanical Properties of Nano-MgO Modified Cement Soil." Sustainability 13, no. 6 (2021): 3558. http://dx.doi.org/10.3390/su13063558.
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In order to explore the modification effect of carbonization time on nano-MgO-modified cement soil, unconfined compressive strength tests of nano-MgO-modified cement soil with carbonization times of 0 h, 6 h, 1 d, 2 d and 4 d were carried out. A method for normalizing the stress–strain curve was proposed, and the influence of nano-MgO content and carbonization time was investigated from the three aspects of compressive strength, peak strain and energy dissipation. The test results show the following: (1) The compressive strength of the modified cement soil can be significantly improved by adding 1.0% nano-MgO and after 1 d carbonization. (2) Under the same nano-MgO content, the peak strain of the modified cement soil after 2 d carbonization reaches the maximum, which can significantly increase its ductility. However, the nano-MgO content has little influence on the peak strain of the modified cement soil. (3) Under the same nano-MgO content, the energy dissipation rate of the modified cement soil after 1 d carbonization reaches the maximum, which can better resist the damage of external load.
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Anzai, Akihito, Fumiya Takata, Toshiki Gushi, Kaoru Toko, and Takashi Suemasu. "Epitaxial growth and magnetic properties of Fe 4− x Mn x N thin films grown on MgO(0 0 1) substrates by molecular beam epitaxy." Journal of Crystal Growth 489 (May 2018): 20–23. http://dx.doi.org/10.1016/j.jcrysgro.2018.02.037.
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Braun, Julian. "Die Zulässigkeit von ärztlichen Fernbehandlungsleistungen nach der Änderung des §7 Abs. 4 MBO-Ä." Medizinrecht 36, no. 8 (2018): 563–68. http://dx.doi.org/10.1007/s00350-018-5010-0.
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