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Journal articles on the topic 'Multicomponent Reaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Zhu, Shizheng, Yong Xu, and Guifang Jin. "A novel synthesis of N-fluoroalkanesulfonylamidines using a three-component reaction." Canadian Journal of Chemistry 81, no. 4 (2003): 265–68. http://dx.doi.org/10.1139/v03-032.

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A novel, general, and efficient multicomponent reaction of fluoroalkanesulfonyl azides, secondary amines, and carbonyl compounds for the synthesis of N-fluoroalkanesulfonylamidines is presented. This reaction gave a good yield of products under very mild reaction conditions.Key words: multicomponent reactions, synthetic methods, N-fluoroalkanesulfonyl azide, N-fluoroalkanesulfonylamidine.

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2

Jørgensen, K., A. Carlone, S. Cabrera, and M. Marigo. "Multicomponent Domino Reaction." Synfacts 2007, no. 3 (2007): 0321. http://dx.doi.org/10.1055/s-2007-968238.

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3

Boltjes, André. "Ugi Multicomponent Reaction." Organic Syntheses 94 (2017): 54–65. http://dx.doi.org/10.15227/orgsyn.094.0054.

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4

Shaabani, Ahmad, Hassan Farhid, Mohammad Mahdi Rostami, and Behrouz Notash. "Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions." SynOpen 05, no. 03 (2021): 167–72. http://dx.doi.org/10.1055/a-1533-3823.

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AbstractAn efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions. 3-Carboxamido-isobutyric acids bearing an amide bond were obtained via Bargellini multicomponent reaction from isocyanides, acetone, and chloroform in the presence of sodium hydroxide. Next, via a Passerini multicomponent-reaction strategy, a new class of depsipeptides was synthesized using the Bargellini reaction products, isocyanides, and aldehydes. The depsipeptides thus prepared h

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5

Méndez, Yanira, Vidal Aldrin Vasco, Galway Ivey, et al. "Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process." Angewandte Chemie International Edition 62 (September 8, 2023): e202311186. https://doi.org/10.1002/anie.202311186.

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Abstract: Multicomponent reactions are of utmost importance at generating a unique, wide, and complexchemical space. Herein we describe a novel multicomponent approach based on the combination of theisonitrile-tetrazine (4+1) cycloaddition and the Ugi four-component reaction to generate pyrazole amidederivatives. The scope of the reaction as well as mechanistic insights governing the 4H-pyrazol-4-iminetautomerization are provided. This multicomponent process provides access to a new chemical space ofpyrazole amide derivatives and offers a tool for peptide modification and stapling.

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Thirumeni, Subramanian, Choumini Balasanthiran, and Grigoriy Sereda. "The Catalytic Activity of TiO2 Toward a Multicomponent Reaction Depends on its Morphology, Mechanoactivation and Presence of Visible Light." Journal of Photocatalysis 1, no. 1 (2020): 37–42. http://dx.doi.org/10.2174/2665976x01666200128150101.

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Aims: Test the hypothesis that the catalytic activity of TiO2 nanoparticles towards a liquidphase or mechanoactivated multicomponent reaction can be tuned by visible light and the shape of nanoparticles. Background: Catalytic multicomponent reactions have been proven to be excellent synthetic approaches to a series of biologically relevant compounds including 2-amino-4H-benzo[b]pyrans. However, the potential photocatalytic activity and structural diversity of nanostructured catalysts remained underutilized in the design of new catalytic systems. Objective: Harness the photocatalytic potential

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7

Huang, Yijun, and Alexander Dömling. "The Gewald multicomponent reaction." Molecular Diversity 15, no. 1 (2010): 3–33. http://dx.doi.org/10.1007/s11030-010-9229-6.

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8

Mardjan, Muhammad Idham Darussalam, Jean Luc Parrain та Laurent Commeiras. "Copper-Catalyzed-Multicomponent Reaction towards the Synthesis of γ-Hydroxybutyrolactams". Materials Science Forum 1061 (26 травня 2022): 151–56. http://dx.doi.org/10.4028/p-yux0t7.

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Copper-catalyzed-multicomponent reaction has been applied to prepare several examples γ-hydroxybutyrolactams. The synthesis of γ-hydroxybutyrolactams occurred via cascade sequence comprising Sonogashira coupling, heterocyclization and nucleophilic addition reactions. The reaction involved the starting materials of (Z)-3-iodobutenoic acid, terminal alkynes and butylamine. The results showed that electronic effect of terminal alkynes played important role in synthesis of γ-hydroxybutyrolactams. The multicomponent reaction allowed us to obtain the desired products and to create multiple bonds in

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9

Fan, Xia, Rongshun Chen, Jie Han, and Zhengjie He. "Convergent Synthesis of Polysubstituted Furans via Catalytic Phosphine Mediated Multicomponent Reactions." Molecules 24, no. 24 (2019): 4595. http://dx.doi.org/10.3390/molecules24244595.

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Tri- or tetrasubstituted furans have been prepared from terminal activated olefins and acyl chlorides or anhydrides by a multicomponental convergent synthesis mode. Instead of stoichiometric nBu3P, only catalytic nBu3P or nBu3P=O is needed to furnish the furans in modest to excellent yields with a good functional group tolerance under the aid of reducing agent silane. This synthetic method features a silane-driven catalytic intramolecular Wittig reaction as a key annulation step and represents the first successful application of catalytic Wittig reaction in multicomponent cascade reaction.

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10

Kasar, Sandeep B., and Shankar R. Thopate. "Ultrasonically Assisted Efficient and Green Protocol for the Synthesis of 4H-isoxazol-5-ones using Itaconic Acid as a Homogeneous and Reusable Organocatalyst." Current Organocatalysis 6, no. 3 (2019): 231–37. http://dx.doi.org/10.2174/2213337206666190411115402.

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Background: Multicomponent reactions involve the simultaneous reaction of three or more components which deliver the product that incorporates the elements of all starting materials. A combination of multicomponent reaction and green solvents like water and the use of nonconventional energy sources like microwave or ultrasonication are important features of ideal green synthesis. Therefore, the design of a new multicomponent reaction and improvement of an already known multicomponent reaction with a green procedure has attracted the attention of the scientific community. Isoxazole derivatives

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11

Boukis, Andreas C., Baptiste Monney, and Michael A. R. Meier. "Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions." Beilstein Journal of Organic Chemistry 13 (January 9, 2017): 54–62. http://dx.doi.org/10.3762/bjoc.13.7.

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The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized dihydropyrimidone–α-acyloxycarboxamide compounds were obtained in good to excellent yields. In a first reaction step, different 3,4-dihydropyrimidin-2(1H)-one acids were synthesized, isolated and fully characterized. These products were subsequently used in a Passerini reaction utilizing a dichloromethane/dimethyl sulfoxide solvent mixture. By variation

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12

Fu, Qiang, Jie Tian, Yongfei Liu, Zhilin Qi, Hongmei Jiao, and Shenyao Yang. "Comparison of the Reaction Characteristics of Different Fuels in the Supercritical Multicomponent Thermal Fluid Generation Process." Energies 17, no. 21 (2024): 5376. http://dx.doi.org/10.3390/en17215376.

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Supercritical multicomponent thermal fluid technology is a new technology with obvious advantages in offshore heavy oil recovery. However, there is currently insufficient understanding of the generation characteristics of the supercritical multicomponent thermal fluid, which is not conducive to the promotion and application of this technology. In order to improve the economic benefits and applicability of the supercritical multicomponent thermal fluid thermal recovery technology, this article reports on indoor supercritical multicomponent thermal fluid generation experiments and compares the r

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13

Patel, Dhaval B., Jagruti A. Parmar, Siddharth S. Patel, Unnati J. Naik, and Hitesh D. Patel. "Recent Advances in Ester Synthesis by Multi-Component Reactions (MCRs): A Review." Current Organic Chemistry 25, no. 5 (2021): 539–53. http://dx.doi.org/10.2174/1385272825666210111111805.

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The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is one of the preferable processes in synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological applications in the pharmaceutical field. Therefore, many methods have been developed for the synthesis of these types of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields, longer reaction times, low selectivities, and byproducts. Thus, the development of new synthetic methods for ester s

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14

Maeda, Satoshi, Shinsuke Komagawa, Masanobu Uchiyama, and Keiji Morokuma. "Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four-Component Reaction." Angewandte Chemie International Edition 50, no. 3 (2010): 644–49. http://dx.doi.org/10.1002/anie.201005336.

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15

Maeda, Satoshi, Shinsuke Komagawa, Masanobu Uchiyama, and Keiji Morokuma. "Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four-Component Reaction." Angewandte Chemie 123, no. 3 (2010): 670–75. http://dx.doi.org/10.1002/ange.201005336.

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16

Attorresi, Cecilia I., Javier A. Ramírez, and Bernhard Westermann. "Formaldehyde surrogates in multicomponent reactions." Beilstein Journal of Organic Chemistry 21 (March 13, 2025): 564–95. https://doi.org/10.3762/bjoc.21.45.

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Formaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity. One notable issue is the challenge of controlling the formation of undesired byproducts during its reactions. This review explores alternative C1-building blocks that serve as surrogates for formaldehyde, aiming to mitigate some of the challenges associated with its use in multicomponent reactions. By identifying these alternatives, toxicity concerns and impro

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17

Zhu, Siyu, Xiaofei Chen, Wei Chen та ін. "Multicomponent synthesis of novel β-carboline-fused imidazolium derivatives via the Mannich reaction: cytotoxicity, molecular docking, and mechanistic studies as angiogenesis inhibitors". New Journal of Chemistry 46, № 9 (2022): 4427–35. http://dx.doi.org/10.1039/d1nj05471f.

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18

Sakhno, Yana, Maksym Mykhailenko, Maksim Kolosov, et al. "Condition-based switching the multicomponent reactions of 5-amino-3-(methylthio)-1,2,4-triazole, aromatic aldehydes, and pyruvic acid." Ukr. Bioorg. Acta 2020, Vol. 15, N2 15, no. 2 (2020): 22–26. http://dx.doi.org/10.15407/bioorganica2020.02.022.

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The multicomponent reactions of 5-amino-3-methylthio-1,2,4-triazole with aromatic aldehydes and pyruvic acid were studied using conventional thermal heating and ultrasonic activation at room temperature. Under conventional heating, dihydrotriazolopyrimidine derivatives were formed in both two- and three-component treatments. In the case of ultrasonic activation, the multicomponent reaction led to the formation of 7-hydroxytetrahydrotriazolopyrimidines.

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19

Serafini, Marta, Ilaria Murgia, Mariateresa Giustiniano, Tracey Pirali, and Gian Cesare Tron. "The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications." Molecules 26, no. 3 (2021): 558. http://dx.doi.org/10.3390/molecules26030558.

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Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929–1966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharin

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20

Gao, Shuang, Tobias Stopka, and Meike Niggemann. "Calcium-Catalyzed Dynamic Multicomponent Reaction." Organic Letters 17, no. 20 (2015): 5080–83. http://dx.doi.org/10.1021/acs.orglett.5b02593.

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21

P, Rahul, Joice Thomas, Wim Dehaen, and Jubi John. "Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach." Molecules 28, no. 1 (2022): 308. http://dx.doi.org/10.3390/molecules28010308.

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The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)—intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each me

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22

Rajiv, Karmakar, and Mukhopadhyay Chhanda. "Microwave irradiation in organic synthesis towards the construction of biologically active N-heterocycles." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1409–41. https://doi.org/10.5281/zenodo.5652956.

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Department of Chemistry, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India Department of Chemistry, Dum Dum Motijheel College (West Bengal State University), Kolkata-700 074, India E-mail: cmukhop@yahoo.co.in, rajivkarmakar84@gmail.com <em>Manuscript received on line 07 October 2018, accepted 01 November 2018</em> In the past few years, using microwave energy to heat and drive chemical reactions has become progressively more popular theme in the scientific community. Microwave-assisted organic synthesis is proving to be instrumental in the rapid synthesis of com

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23

Imtiaz, Shah, Jahangir Ahmad war, Syqa Banoo та Sarfaraz khan. "α-Aminoazoles/azines: key reaction partners for multicomponent reactions". RSC Advances 11, № 19 (2021): 11083–165. http://dx.doi.org/10.1039/d1ra00392e.

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24

Sahoo, Biswa Mohan, B. V. V. Ravi Kumar, Jnyanaranjan Panda, and S. C. Dinda. "Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation." Journal of Nanoparticles 2013 (April 8, 2013): 1–6. http://dx.doi.org/10.1155/2013/780786.

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A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional dr

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25

Vavsari, Vaezeh Fathi, Pegah Shakeri, and Saeed Balalaie. "Application of Chiral Isocyanides in Multicomponent Reactions." Current Organic Chemistry 24, no. 2 (2020): 162–83. http://dx.doi.org/10.2174/1385272824666200110095120.

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As one of the most important building blocks in organic synthesis, isocyanides come in for a wide range of transformations owing mostly to their unusual terminal carbon center adsorbed electrophiles, reacted with nucleophiles, get involved in radical reactions and coordinated with metal centers. The distinctive feature of isocyanide is its ready willingness to participate in multicomponent reactions (MCRs). MCRs represent a great tool in organic synthesis for the construction of new lead structures in a single procedure introducing both structural diversity and molecular complexity in only one

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26

Rosamilia, Anthony E., Christopher R. Strauss, and Janet L. Scott. "Distillable ionic liquids for a new multicomponent reaction." Pure and Applied Chemistry 79, no. 11 (2007): 1869–77. http://dx.doi.org/10.1351/pac200779111869.

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Adducts of dimethylamine and carbon dioxide form a "distillable ionic liquid" (DIMCARB) that may used as both a reaction medium and catalyst in the direct, atom-economical synthesis of useful synthetic building blocks, such as mono-condensed α,β-unsaturated ketones. The utilization of such building blocks in the synthesis of two new classes of versatile macrocycles, by a sequence of condensation reactions (H2O by-product), is described. Investigation into the mechanism of action of DIMCARB catalysis and observation of an aniline impurity arising from a competing reaction sequence led to develo

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27

Pooja Rani. "Multicomponent synthesis of heterocyclic compounds." International Journal for Research Publication and Seminar 11, no. 3 (2020): 223–33. http://dx.doi.org/10.36676/jrps.v11.i3.1184.

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Rapid and efficient, multicomponent domino reactions (MDRs) are a useful tool for the one-pot synthesis of flexible heterocycles with diverse and complicated structures. Reduced chemical waste, lower starting-material prices, and lower energy and labour requirements are all possible thanks to these reactions. Additionally, the time required for a response may be greatly reduced. The most up-to-date research on multicomponent domino reactions for constructing heterocyclic skeletons with five, six, or seven members, as well as their multicyclic derivatives, is discussed in this Review. In recent

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28

Nath, Ashutosh, John Mark Awad, and Wei Zhang. "A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones." Beilstein Journal of Organic Chemistry 21 (June 13, 2025): 1161–69. https://doi.org/10.3762/bjoc.21.92.

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A new synthetic route initiated with Groebke–Blackburn–Bienaymé (GBB) followed by N-acylation, intramolecular Diels–Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the substitution groups for the IMDA reaction is performed to understand the reaction mechanism.

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29

Bosica, Giovanna, and Roderick Abdilla. "Combination of aza-Friedel Crafts MCR with Other MCRs Under Heterogeneous Conditions." Catalysts 15, no. 7 (2025): 657. https://doi.org/10.3390/catal15070657.

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Multicomponent reactions (MCRs) enable the efficient assembly of complex small molecules via multiple bond-forming events in a single step. However, individual MCRs typically yield products with similar core structures, limiting access to larger, more intricate scaffolds. Strategic selection of reactants allows the combination of distinct MCRs, thus facilitating the synthesis of advanced molecular architectures with potential biological significance. Using our previously reported method for performing the aza-Friedel Crafts multicomponent reaction under green heterogeneous conditions, we have

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30

Cankařová, Naděžda, and Viktor Krchňák. "Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application." International Journal of Molecular Sciences 21, no. 23 (2020): 9160. http://dx.doi.org/10.3390/ijms21239160.

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Drug discovery efforts largely depend on access to structural diversity. Multicomponent reactions allow for time-efficient chemical transformations and provide advanced intermediates with three or four points of diversification for further expansion to a structural variety of organic molecules. This review is aimed at solid-phase syntheses of small molecules involving isocyanide-based multicomponent reactions. The majority of all reported syntheses employ the Ugi four-component reaction. The review also covers the Passerini and Groebke-Blackburn-Bienaymé reactions. To date, the main advantages

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31

Bosica, Giovanna, and Roderick Abdilla. "Novel Biopolymer-Based Catalyst for the Multicomponent Synthesis of N-aryl-4-aryl-Substituted Dihydropyridines Derived from Simple and Complex Anilines." Molecules 29, no. 8 (2024): 1884. http://dx.doi.org/10.3390/molecules29081884.

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Although Hantzsch synthesis has been an established multicomponent reaction method for more than a decade, its derivative, whereby an aniline replaces ammonium acetate as the nitrogen source, has not been explored at great length. Recent studies have shown that the products of such a reaction, N-aryl-4-aryldihydropyridines (DHPs), have significant anticancer activity. In this study, we successfully managed to synthesize a wide range of DHPs (18 examples, 8 of which were novel) using a metal-free, mild, inexpensive, recoverable, and biopolymer-based heterogeneous catalyst, known as piperazine,

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32

Murlykina, Maryna V., Oleksandr V. Kolomiets, Maryna M. Kornet, et al. "Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction." Beilstein Journal of Organic Chemistry 15 (June 12, 2019): 1281–88. http://dx.doi.org/10.3762/bjoc.15.126.

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Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and s

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33

Zavarise, Clara, Jean-Christophe Cintrat, Eugénie Romero, and Antoine Sallustrau. "Isocyanate-based multicomponent reactions." RSC Advances 14, no. 53 (2024): 39253–67. https://doi.org/10.1039/d4ra04152f.

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de la Torre, Alexander F., Gabriel S. Scatena, Oscar Valdés, Daniel G. Rivera, and Márcio W. Paixão. "Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis." Beilstein Journal of Organic Chemistry 15 (June 4, 2019): 1210–16. http://dx.doi.org/10.3762/bjoc.15.118.

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The multicomponent synthesis of prolyl pseudo-peptide catalysts using the Ugi reaction with furfurylamines or isocyanides is described. The incorporation of such a polymerizable furan handle enabled the subsequent polymerization of the peptide catalyst with furfuryl alcohol, thus rendering polyfurfuryl alcohol-supported catalysts for applications in heterogeneous enamine catalysis. The utilization of the polymer-supported catalysts in both batch and continuous-flow organocatalytic procedures proved moderate catalytic efficacy and enantioselectivity, but excellent diastereoselectivity in the as

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35

Onwukamike, Kelechukwu Nnabuike, Stéphane Grelier, Etienne Grau, Henri Cramail, and Michael A. R. Meier. "On the direct use of CO2in multicomponent reactions: introducing the Passerini four component reaction." RSC Advances 8, no. 55 (2018): 31490–95. http://dx.doi.org/10.1039/c8ra07150k.

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We introduce a novel isocyanide-based multicomponent reaction, the Passerini four component reaction (P-4CR), by replacing the carboxylic acid component of a conventional Passerini three component reaction (P-3CR) with an alcohol and CO<sub>2</sub>.

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36

Fang, Yi, Can Liu, Fei Wang, Rao Ding, Shun-Yi Wang, and Shun-Jun Ji. "A radical-chain reaction of isocyanides with selenosulfonates and water: facile synthesis of selenocarbamates under metal-free conditions." Organic Chemistry Frontiers 6, no. 5 (2019): 660–63. http://dx.doi.org/10.1039/c8qo01364k.

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A facile synthesis of secondary selenocarbamates through metal-free multicomponent reactions of isocyanides, selenosulfonates and water is reported here. The reaction is easy to handle and proceeds smoothly under mild conditions.

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37

Zhang, Ze, Zi-Bin Tan, Chun-Yan Hong, De-Cheng Wu, and Ye-Zi You. "One-pot sequential multicomponent reaction and a multicomponent polymerization method for the synthesis of topologically different polymers." Polymer Chemistry 7, no. 7 (2016): 1468–74. http://dx.doi.org/10.1039/c5py01758k.

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38

Saha, Argha, Asim Jana, and Lokman H. Choudhury. "Lemon juice mediated multicomponent reactions for the synthesis of fused imidazoles." New Journal of Chemistry 42, no. 22 (2018): 17909–22. http://dx.doi.org/10.1039/c8nj03480j.

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A green approach for the synthesis of diverse medicinally important tricyclic fused imidazoles has been described using one-pot multicomponent reactions in lemon juice as a biocatalyst as well as the reaction medium.

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39

da Silva-Filho, Luiz, Bruno da Silva, and Lucas Martins. "Niobium Pentachloride Catalyzed Multicomponent Povarov Reaction." Synlett 23, no. 13 (2012): 1973–77. http://dx.doi.org/10.1055/s-0032-1316587.

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40

Grimaud, Laurence, Laurent El Kaim, and Aurélie Schiltz. "Isocyanide-Based Multicomponent Reaction ‘without’ Isocyanides." Synlett 2009, no. 09 (2009): 1401–4. http://dx.doi.org/10.1055/s-0029-1217184.

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41

Byk, G., and E. Kabha. "A Solid-Supported Stereoselective Multicomponent Reaction." Synfacts 2006, no. 7 (2006): 0739. http://dx.doi.org/10.1055/s-2006-941902.

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42

Keshtegar, Zahra, Reza Heydari, and Alireza Samzadeh-Kermani. "N-Methylpiperidine assisted catalytic multicomponent reaction." Monatshefte für Chemie - Chemical Monthly 151, no. 2 (2020): 213–22. http://dx.doi.org/10.1007/s00706-019-02544-x.

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Kriis, Kadri, Kerti Ausmees, Tõnis Pehk, Margus Lopp, and Tõnis Kanger. "A Novel Diastereoselective Multicomponent Cascade Reaction." Organic Letters 12, no. 10 (2010): 2230–33. http://dx.doi.org/10.1021/ol1005714.

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44

Konstantinidou, Markella, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuscik, and Alexander Dömling. "Glutarimide Alkaloids Through Multicomponent Reaction Chemistry." European Journal of Organic Chemistry 2018, no. 47 (2018): 6714–19. http://dx.doi.org/10.1002/ejoc.201801276.

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Huang, Yijun, and Alexander Doemling. "ChemInform Abstract: The Gewald Multicomponent Reaction." ChemInform 42, no. 34 (2011): no. http://dx.doi.org/10.1002/chin.201134257.

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Guida, Vincenzo, Raffaella Ocone, and Gianni Astarita. "Diffusion-convection-reaction in multicomponent mixtures." AIChE Journal 40, no. 10 (1994): 1665–68. http://dx.doi.org/10.1002/aic.690401008.

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Elders, Niels, Eelco Ruijter, Frans J J. de Kanter, et al. "A Multicomponent Reaction TowardsN-(Cyanomethyl)amides." Chemistry - A European Journal 15, no. 25 (2009): 6096–99. http://dx.doi.org/10.1002/chem.200900785.

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Seifert, H. J. "Reaction Path Simulations in Multicomponent Materials." International Journal of Materials Research 90, no. 12 (1999): 1016–24. http://dx.doi.org/10.1515/ijmr-1999-901210.

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Bálint, Erika, Nóra Popovics-Tóth, Ádám Tajti, Bettina Rávai, Kármen Emőke Szabó, and Franc Perdih. "Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates." Chemistry Proceedings 3, no. 1 (2020): 108. http://dx.doi.org/10.3390/ecsoc-24-08548.

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Abstract:

Organophosphorus compounds play an important role in the medicinal- or agricultural industry, and in the human body as well. Over the last years, heterocyclic phosphonates have received growing interest due to their potential biological activity. An efficient tool for the preparation of such derivatives is their synthesis via multicomponent reactions. These transformations possess several criteria of an “ideal synthesis”, such as high atom economy, fast and simple accomplishment, energy efficiency, and environmentally friendliness. A number of heterocyclic phosphonates were prepared by us util

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Jumbam, Ndze Denis, and Wayiza Masamba. "Bio-Catalysis in Multicomponent Reactions." Molecules 25, no. 24 (2020): 5935. http://dx.doi.org/10.3390/molecules25245935.

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Abstract:

Enzyme catalysis is a very active research area in organic chemistry, because biocatalysts are compatible with and can be adjusted to many reaction conditions, as well as substrates. Their integration in multicomponent reactions (MCRs) allows for simple protocols to be implemented in the diversity-oriented synthesis of complex molecules in chemo-, regio-, stereoselective or even specific modes without the need for the protection/deprotection of functional groups. The application of bio-catalysis in MCRs is therefore a welcome and logical development and is emerging as a unique tool in drug dev

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