Relevant bibliographies by topics / Multicomponent reactions (MCRs)

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Academic literature on the topic 'Multicomponent reactions (MCRs)'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Multicomponent reactions (MCRs)"

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Reguera, Leslie, Cecilia I. Attorresi, Javier A. Ramírez, and Daniel G. Rivera. "Steroid diversification by multicomponent reactions." Beilstein Journal of Organic Chemistry 15 (June 6, 2019): 1236–56. http://dx.doi.org/10.3762/bjoc.15.121.

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Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs, including the synthesis of steroidal heterocycles and macrocycles as well as the conjugation of steroids to amino acids, peptides and carbohydrates. We demonstrate that steroids are available with almost all types of MCR reactive functionalities, e.g., carbonyl, carboxylic acid, alkyne, amine, isocyanide, boronic acid, etc., and that steroids are suit
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Lee, Daesung, and Sourav Ghorai. "Aryne-Based Multicomponent Coupling Reactions." Synlett 31, no. 08 (2020): 750–71. http://dx.doi.org/10.1055/s-0039-1690824.

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Multicomponent reactions (MCRs) constitute a powerful synthetic tool to generate a large number of small molecules with high atom economy, which thus can efficiently expand the chemical space with molecular diversity and complexity. Aryne-based MCRs offer versatile possibilities to construct functionalized arenes and benzo-fused heterocycles. Because of their electrophilic nature, arynes couple with a broad range of nucleophiles. Thus, a variety of aryne-based MCRs have been developed, the representative of which are summarized in this account.1 Introduction2 Aryne-Based Multicomponent Reactio
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Ugi, Ivar. "Recent progress in the chemistry of multicomponent reactions." Pure and Applied Chemistry 73, no. 1 (2001): 187–91. http://dx.doi.org/10.1351/pac200173010187.

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The chemistry of multicomponent reactions (MCRs) and isocyanides belongs to three periods: In the century 1859­1958, isocyanide chemistry was moderately active and was separate from the classical name reactions of the MCRs. In the next period, isocyanides became well available, and MCRs of isocyanides became the most variable way of forming chemical compounds. The year 1993 began a new era of the formation and investigation of the products and the libraries of the Ugi reaction (U-4CR) and higher MCRs of the isocyanides. This chemistry is primarily accomplished in the industrial search and prep
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Bosica, Giovanna, and Roderick Abdilla. "Combination of aza-Friedel Crafts MCR with Other MCRs Under Heterogeneous Conditions." Catalysts 15, no. 7 (2025): 657. https://doi.org/10.3390/catal15070657.

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Multicomponent reactions (MCRs) enable the efficient assembly of complex small molecules via multiple bond-forming events in a single step. However, individual MCRs typically yield products with similar core structures, limiting access to larger, more intricate scaffolds. Strategic selection of reactants allows the combination of distinct MCRs, thus facilitating the synthesis of advanced molecular architectures with potential biological significance. Using our previously reported method for performing the aza-Friedel Crafts multicomponent reaction under green heterogeneous conditions, we have
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Koszytkowska-Stawińska, Mariola, and Włodzimierz Buchowicz. "Multicomponent reactions in nucleoside chemistry." Beilstein Journal of Organic Chemistry 10 (July 29, 2014): 1706–32. http://dx.doi.org/10.3762/bjoc.10.179.

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This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized types of the MCRs. Biochemical properties of the novel nucleoside analogs are also presented (if provided by the authors).
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Gulati, Shivani, Stephy Elza John, and Nagula Shankaraiah. "Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects." Beilstein Journal of Organic Chemistry 17 (April 19, 2021): 819–65. http://dx.doi.org/10.3762/bjoc.17.71.

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Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged as one of the useful tools in the synthesis of biologically relevant heterocycles. These reactions are strategically employed for the generation of a variety of heterocycles along with multiple point diversifications. Over the last few decades classical MCRs such as Ugi, Biginelli, etc. have witnessed enhanced yield and efficiency with microwave assistance. The highlights of MWA-MCRs are high yields, reduced reaction time, selectivity, atom economy and simpler purification techniques, such an approach can accele
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Jumbam, Ndze Denis, and Wayiza Masamba. "Bio-Catalysis in Multicomponent Reactions." Molecules 25, no. 24 (2020): 5935. http://dx.doi.org/10.3390/molecules25245935.

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Enzyme catalysis is a very active research area in organic chemistry, because biocatalysts are compatible with and can be adjusted to many reaction conditions, as well as substrates. Their integration in multicomponent reactions (MCRs) allows for simple protocols to be implemented in the diversity-oriented synthesis of complex molecules in chemo-, regio-, stereoselective or even specific modes without the need for the protection/deprotection of functional groups. The application of bio-catalysis in MCRs is therefore a welcome and logical development and is emerging as a unique tool in drug dev
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Zhi, Sanjun, Xiaoming Ma, and Wei Zhang. "Consecutive multicomponent reactions for the synthesis of complex molecules." Organic & Biomolecular Chemistry 17, no. 33 (2019): 7632–50. http://dx.doi.org/10.1039/c9ob00772e.

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Vavsari, Vaezeh Fathi, Pegah Shakeri, and Saeed Balalaie. "Application of Chiral Isocyanides in Multicomponent Reactions." Current Organic Chemistry 24, no. 2 (2020): 162–83. http://dx.doi.org/10.2174/1385272824666200110095120.

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As one of the most important building blocks in organic synthesis, isocyanides come in for a wide range of transformations owing mostly to their unusual terminal carbon center adsorbed electrophiles, reacted with nucleophiles, get involved in radical reactions and coordinated with metal centers. The distinctive feature of isocyanide is its ready willingness to participate in multicomponent reactions (MCRs). MCRs represent a great tool in organic synthesis for the construction of new lead structures in a single procedure introducing both structural diversity and molecular complexity in only one
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Saranya, Salim, K. R. Rohit, Sankaran Radhika, and Gopinathan Anilkumar. "Palladium-catalyzed multicomponent reactions: an overview." Organic & Biomolecular Chemistry 17, no. 35 (2019): 8048–61. http://dx.doi.org/10.1039/c9ob01538h.

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Dissertations / Theses on the topic "Multicomponent reactions (MCRs)"

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Vasconcelos, Stanley Nunes Siqueira. "Síntese de 5-organoteluro-1H-1,2,3-triazóis-1,4-dissubstituídos, funcionalização via reação de acoplamento cruzado de Sonogashira e síntese one-pot de derivados do indol-3-glioxila e indol-3-glioxil-1,2,3-triazóis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-16012014-141941/.

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No capítulo 1 apresentamos uma síntese eficiente de compostos 5-organoteluro-1H- 1,2,3-triazóis realizada via reação de cicloadição [3+2] entre azidas orgânicas e alquinos substituídos com organotelúrio. Além disso, os 5-organoteluro-1H-1,2,3-triazóis foram funcionalizados na posição 5 do anel triazólico por reação de acoplamento cruzado de Sonogashira. A regioquímica dos produtos de cicloadição foram descritas com base em experimentos de RMN, cálculos teóricos e cristalografia de raio-x. Apresentamos uma proposta mecanística para a cicloadição mediada por cobre, baseada em experimentos de esp
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Fan, Weigang. "Utilisation du HMF en réactions multicomposantes : Accès rapide vers de nouvelles cibles en chimie fine." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEI022/document.

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L’utilisation de matières premières renouvelables pour la production de produits chimiques est un enjeu majeur de l’industrie chimique. Elle vise à répondre aux contraintes environnementales et économiques de disponibilité des ressources fossiles et de limitation de l’empreinte carbone des produits chimiques. Il existe une famille de molécules fonctionnelles directement issues de la biomasse dénommées « molécules plateforme ». Parmi elles, le 5-hydroxyméthylfurfural (HMF), porteur d’une fonction aldéhyde, un motif furanique et un groupe CH2OH, est particulièrement intéressante. Cependant, sa s
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MERCALLI, VALENTINA. "Nitrile N-oxides and nitrile imines as electrophilic partners for the discovery of novel isocyanide multicomponent reactions: an innovative strategy for the synthesis of molecular scaffolds useful in medicinal chemistry." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/86920.

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Saxer, Samantha. "Synthèse de structures macromoléculaires aromatiques et hétérocycliques originales par voies non conventionnelles." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI038.

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Le travail réalisé dans cette thèse concerne la synthèse de nouvelles structures macromoléculaires aromatiques et hétérocycliques. La synthèse de ces polymères a été envisagée par des procédés de polycondensation non conventionnels. A la différence des réactions classiques utilisées en polycondensation, des réactions de condensation « multi-composants » faisant intervenir trois ou quatre fonctions réactives ont été considérées. Les réactions de Debus-Radziszewski, Hantzsch, et Chichibabin, permettant la formation directe de structures aromatiques et ou hétérocycliques ont été plus particulière
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Chuang, Meng-Jung, and 莊孟榕. "The Application of MCRs(Multicomponent Reactions)：The Synthesis of Chiral Base." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/m36sm3.

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碩士<br>國立成功大學<br>化學系碩博士班<br>90<br>Abstract According to the introduction of multicomponent reactions, we can know that the multicomponent reactions supply a new synthetic stratagem. Via variability of the systems having many reagents, variability of alterable substitutes and application of the difunction group, we can utilize these merits to plot many kinds of compounds which we want to get. The most important point is that the multicomponent reactions are one-pot reactions, which we can abridge many steps which we add reagents and handle in the reactive process. The focal point of my s
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Fu, Hung-Kai, and 傅虹愷. "The Application of MCRs（Multicomponent Reactions）：The Modified Chiral ligands for Catalytic Asymmetric Synthesis and Fluorescence Senses." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/08422769945197279991.

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碩士<br>國立成功大學<br>化學系碩博士班<br>93<br>The study used U-4CR as a blueprint to design highly stereoselective multicomponent reactions, which are simple, convenient and changeful, so as to produce some chiral compounds. 　The multicomponent reactions involve mixing an isocyanide, aldehyde and amino acid in methanol. The reactions give chiral products with high optical purity. 　　The reaction is sensitive to the structure of aldehyde and amino acid. Usually the more bulky the substituents are the higher optical purities the products have. The researcher could use the synthetic method to design many chira
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Chen, Fu-Lin, та 陳福琳. "The Application of MCRs(Multicomponent Reaction)：High diastereoselective chiral baseA Exception of Eschweiler-Clarke methylation：Cyclocondensation of α-amino amide with Formaldehyde and Formic acid". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/29648106699470969890.

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碩士<br>國立成功大學<br>化學系碩博士班<br>92<br>Several pairs of enantiomeric α,α'-iminodiacetic acid analogues were prepared separately by highly diastereoselective 3CR,which involves a reaction of an isocyanide, an aldehyde, and an enantiomerically pure amino acid in methanol. Synthesis of each of the enantiomers was controlled by the configuration of the amino acid；L-amino acid produces one enantiomer and D-amino acid generates the other. The diastereoselectivity of the 3CR is very sensitive to the substituent size of both aldehyde and enantiomerically pure amino acid. 　　An exception of Eschweiler-Clarke
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Book chapters on the topic "Multicomponent reactions (MCRs)"

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Banfi, Luca, Andrea Basso, Giuseppe Guanti, and Renata Riva. "Asymmetric Isocyanide-Based MCRs." In Multicomponent Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605118.ch1.

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Zhang, Wei, and Wen-Bin Yi. "Multicomponent Reactions (MCRs)." In SpringerBriefs in Molecular Science. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22596-4_4.

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Ruijter, Eelco, and Romano V. A. Orru. "Discovery of MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch02.

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Vicente-García, Esther, Nicola Kielland, and Rodolfo Lavilla. "Functionalization of Heterocycles by MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch06.

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Dömling, Alexander, and AlAnod D. AlQahtani. "General Introduction to MCRs: Past, Present, and Future." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch01.

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Xing, Dong, and Wenhao Hu. "Diazoacetate and Related Metal-Stabilized Carbene Species in MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch07.

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del Duque, Maria Mar Sanchez, Christophe Allais, Nicolas Isambert, Thierry Constantieux, and Jean Rodriguez. "β-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles." In Synthesis of Heterocycles via Multicomponent Reactions I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_26.

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Huang, Yijun, Kareem Khoury, and Alexander Dömling. "The Piperazine Space in Isocyanide-based MCR Chemistry." In Synthesis of Heterocycles via Multicomponent Reactions I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_27.

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Vasco, Aldrin V., Manuel G. Ricardo, Daniel G. Rivera, and Ludger A. Wessjohann. "Ligation, Macrocyclization, and Simultaneous Functionalization of Peptides by Multicomponent Reactions (MCR)." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1689-5_8.

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Robert, Alice Rinky, Ganja Himavathi, and Maddila Suresh. "Multicomponent Synthesis of Heterocycles by Microwave Irradiation." In Advances in Organic Synthesis. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040524122170003.

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The multicomponent reactions (MCRs) are vital for producing structurally varied molecular objects. Multicomponent reactions (MCRs) contain three or more synthetic stages and are carried out without isolation of any intermediate, thus requiring mild reaction conditions. They are eco-friendly and cost-effective, have a short reaction time, produce higher yields, and require raw materials. The use of microwave irradiation in green organic synthesis sustains some of the aims of “green and sustainable chemistry.” It offers several benefits over the conventional approach in reducing time, reaction r
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