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Journal articles on the topic 'Multiphasic approach'

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Published: 4 June 2021

Last updated: 10 March 2023

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Lanka, Saraswathi, Luke B. Borst, Sheila K. Patterson, and Carol W. Maddox. "A Multiphasic Typing Approach to SubtypeStreptococcus EquiSubspeciesEqui." Journal of Veterinary Diagnostic Investigation 22, no. 6 (2010): 928–36. http://dx.doi.org/10.1177/104063871002200612.

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KOOPS, W. J., and M. GROSSMAN. "Characterization of Poultry Egg Production Using a Multiphasic Approach." Poultry Science 71, no. 3 (1992): 399–405. http://dx.doi.org/10.3382/ps.0710399.

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MATZKO, HELGA M. GENANNT, and Helga M. Gennant Matzko. "A Gestalt Therapy Treatment Approach for Addictions: "Multiphasic Transformation Process"." Gestalt Review 1, no. 1 (1997): 34–55. http://dx.doi.org/10.2307/44394010.

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Abstract Traditional treatments of addictions developed over the past 40 years have been based on various theoretical models of development. None of these address the complexities of addictions' impact on all facets of the functional self. This article presents a flexible "multiphasic transformation process" (MPTP) approach valuing Gestalt therapy principles and considers as its basis the "cycle of experience" as it relates to the progressive nature of growth and change in the process of transformation. The meaning of addiction and addict will be redefined from this new MPTP perspective. Case materials will illustrate the treatment process, and appropriate therapeutic tasks will be suggested for each phase.

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Klimenko, Olena, and Henrique Luis Román Salcedo. "Estudio sobre la personalidad en una muestra de artistas según el campo de desempeño. Personality study on an artist sample across distinct artistic domains." Psicoespacios 9, no. 15 (2015): 71. http://dx.doi.org/10.25057/21452776.354.

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Personality study on an artist sample across distinct artistic domainsResumenEl presente estudio es de enfoque cuantitativo transversal, descriptivo, teniendo como propósito principal: caracterizar el perfil de personalidad en una muestra de artistas de diferentes campos de desempeño creativo, los cuales residen en Colombia (23) y Argentina (3). Para lograr lo anterior, se realizó una medición de las características de personalidad de los participantes con el test MMPI versión abreviada (Minessota Multiphasic Personality Inventory). Los resultados obtenidos corroboran los resultados de estudios anteriores que establecen una relación entre la producción creativa y las perturbaciones psicopatológicas.Palabras clave: creatividad, perfil de personalidad, campo de desempeño artístico, Minnessota Multiphasic Personality Inventory.AbstractThe aim of this study is to characterize the personality profile of an artist sample, proficient in different artistic domains. The research methodology was transversal quantitative, with a descriptive approach. The personality traits of the sample, from Colombia (23) and Argentina (3), were measured by means of the Minnesota Multiphasic Personality Inventory. The results exhibit a strong occurrence of psychopathological markers, with significant differences in the personality profiling from subjects in different artistic domains.Keywords: personality, creativity, domains of artistic performance, Minnesota Multiphasic Personality Inventory.

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Kusumakar, V. "Bipolar disorder: A cyclical condition requiring a multiphasic approach to management." European Neuropsychopharmacology 10 (September 2000): 240–41. http://dx.doi.org/10.1016/s0924-977x(00)80186-8.

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El Hajj, Boutros, Bruno Castanier, Franck Schoefs, and Emilio Bastidas-Arteaga. "Stochastic Multiphasic Multivariate State-Based Degradation and Maintenance Meta-Models for RC Structures Subject to Chloride Ingress." Infrastructures 8, no. 2 (2023): 36. http://dx.doi.org/10.3390/infrastructures8020036.

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The objective of this paper is to propose tools for the lifecycle management of infrastructure by showing the slow degradation processes for which inspection data are accessible, especially the data obtained from non-destructive testing (NDT) and structural health monitoring (SHM). One major characteristic of these degradation processes is their multiphasic nature; consequently, they can be discretised into different phases with specific physical kinematics where specific maintenance actions and measurement techniques can be performed. Within this framework, we propose implementing a degradation meta-modelling approach fed with measurements (NDT, SHM). This approach is based on state-dependent stochastic processes for modelling the degradation and maintenance of reinforced concrete structures that are subjected to chloride-induced deterioration. The benefit of using multiphasic degradation meta-models in the lifecycle management of infrastructure is illustrated through numerical examples that include single and multi-action management policies.

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Lyons, Kathleen Doyle, Linda S. Kennedy, Ethan P. M. Larochelle, et al. "Feasibility of Brigade-Style, Multiphasic Cancer Screening in Rural Honduras." JCO Global Oncology, no. 6 (September 2020): 453–61. http://dx.doi.org/10.1200/jgo.19.00396.

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PURPOSE To evaluate the feasibility of brigade-style, multiphasic cancer screening in Honduras, exploring data from 3 screening events that each tested for multiple cancers on single occasions. METHODS This series of 3 studies each used a single-arm, post-test–only design to explore the feasibility of implementing multiphasic, community-based cancer screening at the same rural location in 2013, 2016, and 2017. The 2013 event for women screened for 2 cancers (breast and cervix), and the 2016 event for women screened for 3 cancers (breast, cervix, and thyroid). The 2017 event for men screened for 5 cancers (skin, prostate, colorectal, oropharynx, and testes). RESULTS Totals of 473 and 401 women participated in the 2013 and 2016 events, respectively, and 301 men participated in the 2017 event. Staffing for each event varied from 33 to 44 people and relied primarily on in-country medical students and local community members. High rates (mean, 88%) of compliance with referral for follow-up testing at clinics and primary care facilities were observed after the screening events. CONCLUSION The multiphasic, community-based approach proved feasible for both women and men and resulted in high rates of compliance with follow-up testing. This approach appears highly replicable: it was conducted multiple times across the years with different screening targets, which could be further scaled elsewhere using the same technique.

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Davis, William J., Kathryn T. Picard, Jonathan Antonetti, et al. "Inventory of chytrid diversity in two temporary forest ponds using a multiphasic approach." Mycologia 110, no. 5 (2018): 811–21. http://dx.doi.org/10.1080/00275514.2018.1510725.

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Grossman, M., and W. J. Koops. "Modeling Extended Lactation Curves of Dairy Cattle: A Biological Basis for the Multiphasic Approach." Journal of Dairy Science 86, no. 3 (2003): 988–98. http://dx.doi.org/10.3168/jds.s0022-0302(03)73682-0.

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Dadhich, Prabhash, Bodhisatwa Das, Pallabi Pal, et al. "A Simple Approach for an Eggshell-Based 3D-Printed Osteoinductive Multiphasic Calcium Phosphate Scaffold." ACS Applied Materials & Interfaces 8, no. 19 (2016): 11910–24. http://dx.doi.org/10.1021/acsami.5b11981.

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Moss, A. R., and D. I. Givens. "Improved differentiation of carbohydrate pools using a multiphasic model to describe gas production from cell wall and cell content fractions compared with that from the whole food." BSAP Occasional Publication 22 (1998): 221–23. http://dx.doi.org/10.1017/s0263967x00032675.

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Whilst it is recognized that most foods contain a number of different carbohydrate pools most applications of the gas production technique do not allow them to be differentiated despite their likely different nutritional attributes. Schofield and Pell (1995) reported that improved fermentation kinetics of the carbohydrate pools could be obtained by making gas production measurements on the whole food and on its neutral-detergent fibre (NDF) fraction, the data on the neutral-detergent solubles (NDS) being calculated by difference. More recently Doane et al. (1996) proposed an expansion of this to include incubation of the ethanol insoluble residue, to enable the NDS fraction of the food to be separated into a soluble carbohydrate and organic acids fraction and a starch and pectin fraction. Another approach is that of Groot et al. (1996) who used a multiphasic model of whole food gas production to show that the gas is produced from more than one food fraction. The objective of the present work was to combine these two approaches to examine the value of the multiphasic model applied to gas production from the isolated NDF and NDS fractions.

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JIANG, NING, XIN-LEI FAN, QIN YANG, ZHUO DU, and CHENG-MING TIAN. "Two novel species of Cryphonectria from Quercus in China." Phytotaxa 347, no. 3 (2018): 243. http://dx.doi.org/10.11646/phytotaxa.347.3.5.

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Cryphonectria species associated with canker disease are presently difficult to identify, because of lack of ex-type cultures with molecular data and few distinguishable characters. During our survey about chestnut blight in western China, Cryphonectria parasitica was confirmed as the most important canker pathogen based on ten morphologically atypical isolates. Two novel species with orange stromata are introduced based on multigene sequence (ITS, TUB1, TUB2) analyses. This is the first study that has established the Cryphonectria species associated with oak canker in China using a multiphasic approach.

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Cocolin, Luca, Rosalinda Urso, Kalliopi Rantsiou, Carlo Cantoni, and Giuseppe Comi. "Multiphasic Approach To Study the Bacterial Ecology of Fermented Sausages Inoculated with a Commercial Starter Culture." Applied and Environmental Microbiology 72, no. 1 (2006): 942–45. http://dx.doi.org/10.1128/aem.72.1.942-945.2006.

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ABSTRACT In this paper, the ability of a commercial starter culture to perform a sausage fermentation is evaluated. Molecular analysis revealed the presence of several strains of the same species contained in the starter culture with different behavior during the fermentation, and the contribution of Lactobacillus curvatus, which was only marginally isolated during the transformation.

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Becerra, Lino, Hans Breiter, R. Gilberto Gonzalez, and David Borsook. "A mean field theory (MFT) approach to fMRI analysis reveals multiphasic activation in response to pain." NeuroImage 11, no. 5 (2000): S655. http://dx.doi.org/10.1016/s1053-8119(00)91585-4.

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Pham, Van Nhat, Dimitri Radajewski, Isaac Rodríguez-Ruiz, and Sebastien Teychene. "Microfluidics: A Novel Approach for Dehydration Protein Droplets." Biosensors 11, no. 11 (2021): 460. http://dx.doi.org/10.3390/bios11110460.

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The equation of state of colloids plays an important role in the modelling and comprehension of industrial processes, defining the working conditions of processes such as drying, filtration, and mixing. The determination of the equation is based on the solvent equilibration, by dialysis, between the colloidal suspension and a reservoir with a known osmotic pressure. In this paper, we propose a novel microfluidic approach to determine the equation of state of a lysozyme solution. Monodispersed droplets of lysozyme were generated in the bulk of a continuous 1-decanol phase using a flow-focusing microfluidic geometry. In this multiphasic system and in the working operation conditions, the droplets can be considered to act as a permeable membrane system. A water mass transfer flow occurs by molecule continuous diffusion in the surrounding 1-decanol phase until a thermodynamic equilibrium is reached in a few seconds to minutes, in contrast with the standard osmotic pressure measurements. By changing the water saturation of the continuous phase, the equation of state of lysozyme in solution was determined through the relation of the osmotic pressure between protein molecules and the volume fraction of protein inside the droplets. The obtained equation shows good agreement with other standard approaches reported in the literature.

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Sapir, Tzuriel, Zaelig Averch, Brian Lerman, Abraham Bodzin, Yeshaya Fishman, and Radhashree Maitra. "COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19." International Journal of Molecular Sciences 23, no. 15 (2022): 8606. http://dx.doi.org/10.3390/ijms23158606.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when exacerbated, can have life-threatening consequences. COVID-19 has been linked to persistent symptoms, sequelae, and medical complications that can last months after the initial infection. This systematic review aims to elucidate the innate and adaptive immune mechanisms involved and identify potential characteristics of COVID-19 pathology that may increase symptom duration. We also describe he three different stages of COVID-19—viral replication, immune hyperactivation, and post-acute sequelae—as well as each phase’s corresponding immune response. Finally, we use this multiphasic approach to describe different treatment approaches for each of the three stages—antivirals, immunosuppressants and monoclonal antibodies, and continued immunosuppressants—to fully curate the treatment to the stage of disease.

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Nie, Xiaolei, Yon Jin Chuah, Pengfei He, and Dong-An Wang. "Engineering a multiphasic, integrated graft with a biologically developed cartilage–bone interface for osteochondral defect repair." Journal of Materials Chemistry B 7, no. 42 (2019): 6515–25. http://dx.doi.org/10.1039/c9tb00822e.

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Stiles, William B., Karen Maitland Schilling, Leonard G. Rorer, et al. "Pluralistic Professional Education: A Modular Curriculum in Clinical Psychology." Teaching of Psychology 19, no. 4 (1992): 211–16. http://dx.doi.org/10.1207/s15328023top1904_2.

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We describe a pluralistic curriculum for doctoral education in clinical psychology. Two successful curricular innovations are highlighted. First, the usual courses in psychopathology, psychological assessment, and intervention are offered as 5-week modules. Each module covers a subtopic within the broader area (e.g., introduction to the Minnesota Multiphasic Personality Inventory as an assessment module and depression as a psychopathology module). Second, students are introduced to alternative psychotherapeutic approaches in practicum courses that integrate didactic material with supervised practice in a particular approach. Students select the modules and practica that meet their career goals. All students acquire a core but not necessarily the same core.

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Trong, Emmanuel Le, Olivier Rozenbaum, Jean-Louis Rouet, and Ary Bruand. "A SIMPLE METHODOLOGY TO SEGMENT X-RAY TOMOGRAPHIC IMAGES OF A MULTIPHASIC BUILDING STONE." Image Analysis & Stereology 27, no. 3 (2011): 175. http://dx.doi.org/10.5566/ias.v27.p175-182.

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Assessment of the weathering of a particular limestone, the tuffeau, used in historical monuments requires an accurate description of its microstructure. An efficient tools to obtain such a description is X-ray microtomography. However the segmentation of the images of this multiphasic material is not trivial. As the identification of pertinent markers of the structural components to extract is difficult, a two steps filtering approach is chosen. Alternate sequential filters are shown to efficiently remove the noise but, as they destroy the structural components smaller than the structuring element used, they cannot be carried out far enough. Hence as a second step in the filtering process, a mosaic operator, relying on a pragmatic yet efficient marker determination, is implemented to simplify further the images.

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Kim, Sunhae, Hye-Kyung Lee, and Kounseok Lee. "Can the MMPI Predict Adult ADHD? An Approach Using Machine Learning Methods." Diagnostics 11, no. 6 (2021): 976. http://dx.doi.org/10.3390/diagnostics11060976.

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(1) Background: Adult attention-deficit/hyperactivity disorder (ADHD) symptoms cause various social difficulties due to attention deficit and impulsivity. In addition, in contrast to ADHD in childhood, ADHD in adulthood is difficult to diagnose due to mixed psychopathologies. This study aimed to determine whether it is possible to predict ADHD symptoms in adults using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) with machine learning (ML) techniques; (2) Methods: Data collected from 5726 college students were analyzed. The MMPI-2-Restructured Form (MMPI-2-RF) was used, and ADHD symptoms in adults were evaluated using the Attention-Deficit/Hyperactivity Disorder Self-Report Scale (ASRS). For statistical analysis, three ML algorithms were used, i.e., K-nearest neighbors (KNN), linear discriminant analysis (LDA), and random forest, with the ASRS evaluation result as the dependent variable and the 50 MMPI-2-RF scales as predictors; (3) Results: When the KNN, LDA, and random forest techniques were applied, the accuracy was 93.1%, 91.2%, and 93.6%, respectively, and the area under the curve (AUC) was 0.722, 0.806, and 0.790, respectively. The AUC of the LDA method was the largest, with an excellent level of diagnostic accuracy; (4) Conclusions: ML using the MMPI-2 in a large group could provide reliable accuracy in screening for adult ADHD.

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de Melo Pereira, Gilberto Vinícius, Karina Teixeira Magalhães, Emi Rainildes Lorenzetii, Thiago Pereira Souza, and Rosane Freitas Schwan. "A Multiphasic Approach for the Identification of Endophytic Bacterial in Strawberry Fruit and their Potential for Plant Growth Promotion." Microbial Ecology 63, no. 2 (2011): 405–17. http://dx.doi.org/10.1007/s00248-011-9919-3.

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Bas, Onur, Sara Lucarotti, Davide D. Angella, et al. "Rational design and fabrication of multiphasic soft network composites for tissue engineering articular cartilage: A numerical model-based approach." Chemical Engineering Journal 340 (May 2018): 15–23. http://dx.doi.org/10.1016/j.cej.2018.01.020.

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Kraková, Lucia, Katarína Chovanová, Samy A. Selim, et al. "A multiphasic approach for investigation of the microbial diversity and its biodegradative abilities in historical paper and parchment documents." International Biodeterioration & Biodegradation 70 (May 2012): 117–25. http://dx.doi.org/10.1016/j.ibiod.2012.01.011.

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Abraham, Deepak, Jinu Kurian Thomas, Philip Joseph, and MJ Paul. "Lateral Laparoscopic Approach to Pancreatic Tail Insulinomas." World Journal of Endocrine Surgery 4, no. 1 (2012): 3–7. http://dx.doi.org/10.5005/jp-journals-10002-1082.

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ABSTRACT Pancreatic endocrine tumors are relatively rare lesions and laparoscopic surgery is being increasingly used, especially for insulinomas because of their relatively small size and low incidence of malignancy. Laparoscopic approach to pancreatic tumors has been described in the supine position, transomentally via the lesser sac with anterior stomach retraction. We propose a simplified lateral laparoscopic approach to insulinomas localized preoperatively to the tail or distal body of pancreas. Four patients with pancreatic tail insulinomas underwent laparoscopic surgery between November 2006 and February 2008. Diagnosis was confirmed by fasting sugar, insulin and proinsulin assays. Lesions were localized by multiphasic CT scan/MRI scan and endoscopic ultrasound. All these cases had definitely identifiable enhancing lesions in the distal body/tail in relation to the splenic hilum that appeared accessible by a lateral approach. Except for the first case which was done through the traditional supine approach, the other cases were done by the lateral approach. The patients were positioned right lateral with a kidney bridge. Four subcostal ports were placed and the left colon and spleen with pancreatic tail were mobilised in the same fashion as for splenectomy or adrenalectomy. Tumors were easily identifiable corresponding to the imaging studies. Laparoscopic enucleation was successfully completed in all four patients with lesions in the tail of pancreas, one by the traditional approach and other three by the proposed lateral approach. One patient had associated splenectomy because of the proximity of the lesion to the splenic vessels. Two patients had minor pancreatic leak managed conservatively. The left lateral transperitoneal laparoscopic approach to insulinomas located in the tail of pancreas is feasible and safe. The procedure can be done with ease by surgeons who are familiar with adrenalectomy and splenectomy. How to cite this article Thomas JK, Abraham D, Joseph P, Paul MJ. Lateral Laparoscopic Approach to Pancreatic Tail Insulinomas. World J Endocr Surg 2012;4(1):3-7.

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Kjeldsen, Kasper Urup, Lone Tang, Maria Giltoft JÃ¸rgensen, and Kjeld Ingvorsen. "Enumeration and identification of dominant types of sulfate-reducing bacteria in pulp from a paper-recycling plant: a multiphasic approach." FEMS Microbiology Ecology 69, no. 3 (2009): 481–94. http://dx.doi.org/10.1111/j.1574-6941.2009.00715.x.

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Solieri, Lisa, Aldo Bianchi, and Paolo Giudici. "Inventory of non starter lactic acid bacteria from ripened Parmigiano Reggiano cheese as assessed by a culture dependent multiphasic approach." Systematic and Applied Microbiology 35, no. 4 (2012): 270–77. http://dx.doi.org/10.1016/j.syapm.2012.04.002.

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Malyshev, Konstantin Borisovich, Nikolay Gurgenovich Sobolev, Aleksey Modestovich Chirkov, Nina Nikolaevna Ershova, and Tatyana Vyacheslavovna Maltseva. "Study of personality accentuations based on a three-factor dichotomic typological approach." SHS Web of Conferences 121 (2021): 02004. http://dx.doi.org/10.1051/shsconf/202112102004.

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A significant problem for practical psychologists is development of own methods necessary for particular and special cases of character research. This requires technologies for creating psychological diagnostic tools that might help to extend, streamline and show a complete picture of the personality, as well as a reliable system for validating the designed instrumentation. Practical psychology needs set forth a social mandate for the development of a classification technology highlighting psychological characteristics of individuals. Purpose of the research: creation of a new methodology for obtaining and measuring information concerning personality accentuations. Methods: a three-factor integrated dichotomic basic approach is used in modelling personality accentuations types and varieties of temperament. The respondents were represented by 187 students of Vologda State University. The research was carried out using the MMPI (Minnesota Multiphasic Personality Inventory) test and Holland’s Professional Test Guide. The correlation analysis was used as well in data processing. The validation of the new methodology for measuring personality accentuations was made in terms of constructive validity. The research results extend the scientific concept defining the role and significance of the processes structuring the personality-specific psychological information, based on the use of a dichotomic three-factor basic approach which in turn will contribute to the development of theoretical psychologist’s creative thinking. In addition, the results are aimed at obtaining complete and ordered measurement information on personality accentuations based on the application of the integrated-dichotomic three-factor basic typological approach that is of particular importance for the formation of practical psychologist’s theoretical reasoning. The research results can be used for the purpose of extension of the psychodiagnostic training content.

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Hailegiorgis, A., Y. Ishida, M. Imamura, et al. "Understanding the multiphasic viral kinetics of cute HBV infection observed in humanized uPA/SCID mice using an agent-based modeling approach." Journal of Hepatology 68 (April 2018): S782—S783. http://dx.doi.org/10.1016/s0168-8278(18)31834-8.

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McGrath, Robert E., Ray Terranova, David L. Pogge, and Celina Kravic. "Development of a Short Form for the MMPI-2 Based on Scale Elevation Congruence." Assessment 10, no. 1 (2003): 13–28. http://dx.doi.org/10.1177/1073191102250333.

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The length of the Minnesota Multiphasic Personality Inventory (MMPI) is often considered a barrier to its use, leading to the development of short forms. Two methods of abbreviating the revised MMPI have now been developed. One agrees poorly with the long form in terms of which scales are elevated. The second ensures perfect congruence in which scales are elevated but requires computer administration. This article describes the development of a short form representing a compromise approach. The short form was derived using 800 psychiatric inpatients and cross-validated with samples of 658 inpatients and 266 outpatients. It is briefer than the computerized short form but does not achieve perfect congruence with the full inventory. It is longer than earlier noncomputerized short forms but demonstrates greater scale elevation congruence with the full inventory and allows estimates of more scales. The short form offers a reasonable alternative when the full inventory is impractical.

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Cho, Hwan-ho, Minsu Park, Hyunjin Park, et al. "The Tumor–Fat Interface Volume of Breast Cancer on Pretreatment MRI Is Associated with a Pathologic Response to Neoadjuvant Chemotherapy." Biology 9, no. 11 (2020): 391. http://dx.doi.org/10.3390/biology9110391.

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Adipocytes are active sources of numerous adipokines that work in both a paracrine and endocrine manner. It is not known that the direct contact between tumor and neighboring fat measured by pretreatment breast magnetic resonance imaging (MRI) affects treatment outcomes to neoadjuvant chemotherapy (NAC) in breast cancer patients. A biomarker quantifying the tumor–fat interface volume from pretreatment MRI was proposed and used to predict pathologic complete response (pCR) in breast cancer patients treated with NAC. The tumor–fat interface volume was computed with data-driven clustering using multiphasic MRI. Our approach was developed and validated in two cohorts consisting of 1140 patients. A high tumor–fat interface volume was significantly associated with a non-pCR in both the development and validation cohorts (p = 0.030 and p = 0.037, respectively). Quantitative measurement of the tumor–fat interface volume based on pretreatment MRI may be useful for precision medicine and subsequently influence the treatment strategy of patients.

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Maalcke, Wouter J., Andreas Dietl, Sophie J. Marritt, et al. "Structural Basis of Biological NO Generation by Octaheme Oxidoreductases." Journal of Biological Chemistry 289, no. 3 (2013): 1228–42. http://dx.doi.org/10.1074/jbc.m113.525147.

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Nitric oxide is an important molecule in all domains of life with significant biological functions in both pro- and eukaryotes. Anaerobic ammonium-oxidizing (anammox) bacteria that contribute substantially to the release of fixed nitrogen into the atmosphere use the oxidizing power of NO to activate inert ammonium into hydrazine (N2H4). Here, we describe an enzyme from the anammox bacterium Kuenenia stuttgartiensis that uses a novel pathway to make NO from hydroxylamine. This new enzyme is related to octaheme hydroxylamine oxidoreductase, a key protein in aerobic ammonium-oxidizing bacteria. By a multiphasic approach including the determination of the crystal structure of the K. stuttgartiensis enzyme at 1.8 Å resolution and refinement and reassessment of the hydroxylamine oxidoreductase structure from Nitrosomonas europaea, both in the presence and absence of their substrates, we propose a model for NO formation by the K. stuttgartiensis enzyme. Our results expand the understanding of the functions that the widespread family of octaheme proteins have.

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Torphy, Robert J., Zhen Wang, Aisha True-Yasaki, et al. "Stromal Content Is Correlated With Tissue Site, Contrast Retention, and Survival in Pancreatic Adenocarcinoma." JCO Precision Oncology, no. 2 (November 2018): 1–12. http://dx.doi.org/10.1200/po.17.00121.

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Purpose Desmoplastic stroma is a cardinal feature of primary pancreatic ductal adenocarcinoma (PDA), but its effects on the biology, prognosis, and therapeutic outcomes in the disease are not known. We developed an automated method to assess tumor stroma density (TSD) and investigated computed tomography (CT) correlates of stroma in PDA. Patients and Methods We collected PDA samples from rapid autopsy and resection series and digitally annotated samples to quantify TSD. A series of patients who had undergone resection also underwent preoperative multiphasic CT imaging. Results Automated and manual assessments of TSD were highly correlated (ρ = 0.65; P < .001). Solid organ metastases had a lower median TSD than primary tumors ( P < .001). Patients whose tumors had high TSD had prolonged recurrence-free survival (hazard ratio [HR] = 0.51; P = .003) and overall survival (HR = 0.57; P = .008). In another independent dataset, patients whose tumors had high TSD had decreased risk for recurrence (HR = 0.03; P = .003) and death (HR = 0.03; P = .003) at time of resection; however, the protective effect of high TSD diminished over time. Patients with a normalized portovenous phase CT tumor enhancement ratio ≥ 0.40 had a longer time to recurrence after resection ( P = .020). Normalized portovenous phase CT tumor enhancement ratio was significantly correlated with TSD ( P = .003). Conclusion Objective quantitative assessment of stroma in PDA revealed several clinically relevant observations. Stroma was less abundant in metastatic PDA, the primary cause of mortality associated with PDA. High stromal content correlated with favorable outcome in patients with resected tumors, implying a protective effect of stroma and suggesting careful consideration of active stromal depletion therapies. Standard, multiphase CT imaging correlated with stroma content and clinical outcome, indicating that noninvasive assessment of stroma is a feasible sensitivity enrichment approach in PDA.

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Rizzi, Angela, Alessia Di Rienzo, Alessandro Buonomo, et al. "Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome." International Journal of Immunopathology and Pharmacology 34 (January 2020): 205873842093462. http://dx.doi.org/10.1177/2058738420934629.

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Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to assess changes of HRQoL after 1 year of NiOHT; (c) to evaluate psychological status of patients. SNAS patients completed the Short-Form 36-Item Health Survey and Psychological General Well-Being Index before and 1 week after the end of NiOHT. Moreover, psychological state was assessed with the Minnesota Multiphasic Personality Inventory (MMPI-2). A total of 52 patients self-reported pre- and post-treatment questionnaires. HRQoL was poor at baseline. After 1 year of NiOHT, all outcome measure scores improved by about 20% with respect to baseline data ( P < 0.01 for all indices, except depressed mood). Finally, 33 patients performed the MMPI-2. High rates for hypochondriasis and depression were noted. Furthermore, most of the patients had high scores for anxiety, depression, and health concerns. This is the first study showing that NiOHT improves HRQoL of SNAS patients, which can be considered a “personalized medicine” approach.

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Rust, Ruslan, Lisa Grönnert, Christina Gantner, et al. "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke." Proceedings of the National Academy of Sciences 116, no. 28 (2019): 14270–79. http://dx.doi.org/10.1073/pnas.1905309116.

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Stroke is a major cause of serious disability due to the brain’s limited capacity to regenerate damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and inflammatory response is coupled with severely restricted vascular and neuronal repair, resulting in permanent functional deficits. Although clinical evidence indicates that revascularization of the ischemic brain regions is crucial for functional recovery, no therapeutics that promote angiogenesis after cerebral stroke are currently available. Besides vascular growth factors, guidance molecules have been identified to regulate aspects of angiogenesis in the central nervous system (CNS) and may provide targets for therapeutic angiogenesis. In this study, we demonstrate that genetic deletion of the neurite outgrowth inhibitor Nogo-A or one of its corresponding receptors, S1PR2, improves vascular sprouting and repair and reduces neurological deficits after cerebral ischemia in mice. These findings were reproduced in a therapeutic approach using intrathecal anti–Nogo-A antibodies; such a therapy is currently in clinical testing for spinal cord injury. These results provide a basis for a therapeutic blockage of inhibitory guidance molecules to improve vascular and neural repair after ischemic CNS injuries.

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Chhun, Ponleu, Laurie Buffo-Lacarriere, and Alain Sellier. "Material and Geometric Heterogeneity Consideration for Cracking Risk Prediction of Young Age Behavior of Experimental Massive Reinforced Concrete Structure." Key Engineering Materials 711 (September 2016): 900–907. http://dx.doi.org/10.4028/www.scientific.net/kem.711.900.

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This article presents the application of a thermo-hydro-chemo-mechanical (THCM) model to a real complex structure of reactor confinement (mock-up VERCORS from EDF) by taking into account the specificities of the construction (construction consequences), the distributed reinforcements and the material heterogeneity of massive structure. The experimental campaigns were conducted during and after the construction of VERCORS. The early-age behavior of concrete is first modelled based on a multiphasic hydration model to ensure the thermal evolution. Then a 3D mechanical model is used to predict the consequences of hydration, temperature and water variations on mechanical behavior. An alternative approach to consider the structural effect of distributed reinforcement without explicit meshing of reinforcements is implemented and is able to reproduce the influence of reinforcement on the crack patterns. Moreover, the “Weakest link localization” method is also adapted to deal with a probabilistic scale effect due to the material heterogeneity of massive structure. It permits to assess directly the most likely tensile strength which can treat the first crack in softening part of the loaded volume of structures.

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Sertić-Milić, Helga, Nikolina Jurjević, Thomas Ferenc, Jelena Svetec-Dvorski, Mirta Zekan-Vučetić, and Vinko Vidjak. "Locoregional treatment approaches for hepatocellular carcinoma – a case report." Libri Oncologici Croatian Journal of Oncology 50, no. 2-3 (2022): 142–45. http://dx.doi.org/10.20471/lo.2022.50.02-03.22.

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A hepatocellular carcinoma (HCC) is a primary liver malignancy, often arising in the setting of chronic liver disease. Incidence of this carcinoma is increasing at a great rate. Disease often manifests asymptomatically and to make the final diagnosis is often challenging. Screening of patients at risk is based on ultrasound (US) examinations, which in the setting of suspicion lesion findings often converts to multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) procedures for advanced disease evaluation. The selection of treatment modality depends on tumor size and location, extrahepatic spread and subsequent liver disease. For years the first line of treatment was liver resection and transplantation. Locoregional therapy is a novel approach to diverse stages of HCC with good response and higher overall survival rates, especially in early stages. Transarterial chemoembolization (TACE) is the method of choice in patients with multifocal HCC and maintained liver function, unsuitable for surgical treatment. We present a patient with HCC in the setting of hepatitis C virus (HCV) infection, treated with combined methods of locoregional therapy.

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Koca, Nizameddin, Soner Cander, Ozen Oz Gul, and Nesrin Uğraş. "Insulinoma Case Admitted with Reactive Hypoglycemia Symptoms." Current Diabetes Reviews 16, no. 7 (2020): 790–96. http://dx.doi.org/10.2174/1573399815666190712200716.

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Aim:: To present an insulinoma case with post-prandial hypoglycemic symptoms associated with glucose inducible endogenous hyperinsulinemia. Case:: A 52-year-old female patient was evaluated for hypoglycemic symptoms especially those occuring within 3 hours after consuming sugary foods. These symptoms were persistent for a year and a half. She was diagnosed with reactive (post-prandial) syndrome and followed a recommended diet and was given acarbose but there was no improvement. The results suggested post-prandial endogenous hyperinsulinemia related hypoglycemia. Multiphasic computerized tomography revealed an 11x15x12 mm size mass lesion, anteriorly in the head and uncinate process of the pancreas and then the patients were treated surgically with pancreatic enucleation and cured. Conclusion:: Distinguishing post-prandial syndrome by careful history and clinical evaluation in patients with postprandial symptoms is of great importance in terms of cost-effectivity. However, it should not be forgotten that although organic pathologies are mostly presented with fasting hypoglycemia, they may also cause post-prandial symptoms. Severity and progression of the symptoms that point to neuroglycopenia is important, and in this condition the most convenient clinical approach to the patient should be performed with careful and appropriate assessment steps.

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Thorne, Alastair, Alisdair I. MacDonald, and Joseph L. Thorley. "The abundance of large, piscivorous Ferox Trout (Salmo trutta) in Loch Rannoch, Scotland." PeerJ 4 (November 1, 2016): e2646. http://dx.doi.org/10.7717/peerj.2646.

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Background Ferox Trout are large, long-lived piscivorous Brown Trout (Salmo trutta). Due to their exceptionally large size, Ferox Trout are highly sought after by anglers while their life-history strategy, which includes delayed maturation, multiphasic growth and extended longevity, is of interest to ecological and evolutionary modelers. However, despite their recreational and theoretical importance, little is known about the typical abundance of Ferox Trout. Methods To rectify this situation a 16 year angling-based mark-recapture study was conducted on Loch Rannoch, which at 19 km2 is one of the largest lakes in the United Kingdom. Results A hierarchical Bayesian Jolly-Seber analysis of the data suggest that if individual differences in catchability are negligible the population of Ferox Trout in Loch Rannoch in 2009 was approximately 71 fish. The results also suggest that a single, often unaccompanied, highly-experienced angler was able to catch roughly 8% of the available fish on an annual basis. Discussion It is recommended that anglers adopt a precautionary approach and release all trout with a fork length ≥400 mm caught by trolling in Loch Rannoch. There is an urgent need to assess the status of Ferox Trout in other lakes.

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De Carli, Angelo, Ferdinando Pulcinelli, Giacomo Rose, Dario Pitino, and Andrea Ferretti. "Calcific tendinitis of the shoulder." Joints 02, no. 03 (2014): 130–36. http://dx.doi.org/10.11138/jts/2014.2.3.130.

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Calcific tendinitis is a common disease that predominantly affects individuals aged between 40 and 60 years. Women seem to be more affected than men. Various factors have been suggested to play a role in this condition, such as abnormal activity of the thyroid gland, metabolic diseases (e.g. diabetes), and genetic predisposition. Various etiological hypotheses have been advanced: the degenerative and multiphasic theories are the two most accredited ones. Clinically, calcific tendinitis is characterized by severe, disabling pain which occurs spontaneously, usually in the morning. There can be concomitant stiffness, giving rise to a frozen shoulder-like clinical picture. Conventional radiography of the shoulder is the most appropriate imaging approach. Most cases resolve spontaneously. Many conservative treatments have been reported in the literature, showing varying levels of evidence of efficacy. Arthroscopic surgery is the orthopedic specialist’s last option. It is to be noted that post-surgical pain can persist for many weeks after the operation. Finally, it is important not to forget the variant characterized by osteolytic involvement of the greater tuberosity, which has been associated with a worse clinical outcome, both after conservative treatment and after surgery.

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Camu, Nicholas, Ángel González, Tom De Winter, et al. "Influence of Turning and Environmental Contamination on the Dynamics of Populations of Lactic Acid and Acetic Acid Bacteria Involved in Spontaneous Cocoa Bean Heap Fermentation in Ghana." Applied and Environmental Microbiology 74, no. 1 (2007): 86–98. http://dx.doi.org/10.1128/aem.01512-07.

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ABSTRACT The influence of turning and environmental contamination on six spontaneous cocoa bean heap fermentations performed in Ghana was studied through a multiphasic approach, encompassing both microbiological (culture-dependent and culture-independent techniques) and metabolite target analyses. A sensory analysis of chocolate made from the fermented, dried beans was performed as well. Only four clusters were found among the isolates of acetic acid bacteria (AAB) identified: Acetobacter pasteurianus, Acetobacter ghanensis, Acetobacter senegalensis, and a potential new Acetobacter lovaniensis-like species. Two main clusters were identified among the lactic acid bacteria (LAB) isolated, namely, Lactobacillus plantarum and Lactobacillus fermentum. No differences in biodiversity of LAB and AAB were seen for fermentations carried out at the farm and factory sites, indicating the cocoa pod surfaces and not the general environment as the main inoculum for spontaneous cocoa bean heap fermentation. Turning of the heaps enhanced aeration and increased the relative population size of AAB and the production of acetic acid. This in turn gave a more sour taste to chocolate made from these beans. Bitterness was reduced through losses of polyphenols and alkaloids upon fermentation and cocoa bean processing.

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Cooksey, Robert C., Michael A. Jhung, Mitchell A. Yakrus, et al. "Multiphasic Approach Reveals Genetic Diversity of Environmental and Patient Isolates of Mycobacterium mucogenicum and Mycobacterium phocaicum Associated with an Outbreak of Bacteremias at a Texas Hospital." Applied and Environmental Microbiology 74, no. 8 (2008): 2480–87. http://dx.doi.org/10.1128/aem.02476-07.

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ABSTRACT Between March and May 2006, a Texas hospital identified five Mycobacterium mucogenicum bloodstream infections among hospitalized oncology patients using fluorescence high-performance liquid chromatography analysis of mycolic acids. Isolates from blood cultures were compared to 16 isolates from environmental sites or water associated with this ward. These isolates were further characterized by hsp65, 16S rRNA, and rpoB gene sequencing, hsp65 PCR restriction analysis, and molecular typing methods, including repetitive element PCR, random amplified polymorphic DNA PCR, and pulsed-field gel electrophoresis (PFGE) of large restriction fragments. Three of five patient isolates were confirmed as M. mucogenicum and were in a single cluster as determined by all identification and typing methods. The remaining two patient isolates were identified as different strains of Mycobacterium phocaicum by rpoB sequence analysis. One of these matched an environmental isolate from a swab of a hand shower in the patient's room, while none of the clinical isolates of M. mucogenicum matched environmental strains. Among the other 15 environmental isolates, 11 were identified as M. mucogenicum and 4 as M. phocaicum strains, all of which were unrelated by typing methods. Although the 16S rRNA gene sequences matched for all 14 M. mucogenicum isolates, there were two each of the hsp65 and rpoB sequevars, seven PCR typing patterns, and 12 PFGE patterns. Among the seven M. phocaicum isolates were three 16S rRNA sequevars, two hsp65 sequevars, two rpoB sequevars, six PCR typing patterns, and six PFGE patterns. This outbreak represents the first case of catheter-associated bacteremia caused by M. phocaicum and the first report of clinical isolates from a U.S. hospital. The investigation highlights important differences in the available typing methods for mycobacteria and demonstrates the genetic diversity of these organisms even within narrow confines of time and space.

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Precenzano, Francesco, Daniela Smirni, Luigi Vetri, et al. "Childhood Obesity and Maternal Personality Traits: A New Point of View on Obesity Behavioural Aspects." Pediatric Reports 13, no. 3 (2021): 538–45. http://dx.doi.org/10.3390/pediatric13030063.

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The epidemic spread of childhood obesity in Western society has interested many researchers, who agree in defining it as a multifactorial disease in which not only eating habits and sedentary lifestyle play a role, but also genetic predisposition. The aim of this study was to analyze the personality profile of a group of mothers of children with obesity and to compare this profile to that of a group of mothers of children without obesity. A total of 258 mothers participated in the study (126 mothers of children with obesity and 132 mothers of children without obesity). Weight and height were measured and the body mass index was calculated. The Minnesota Multiphasic Personality Inventory second edition (MMPI-2), evaluating personality and psychological disorders, was used to evaluate the personality profile. The results suggested that mothers of children with obesity score higher than the mothers of children without obesity in all MMPI-2 subscales. In most of these subscales, the differences between the two groups of mothers were statistically significant and with a medium to high effect size. These data suggest a new perspective on childhood obesity, identifying it as a multifactorial pathology that requires a multimodal and multidisciplinary approach that also takes care of caregivers to ensure optimal therapeutic efficacy.

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Tran, Thi Le Quyen, Hussein Anani, Ho Tinh Trinh, et al. "Chitinophaga vietnamensis sp. nov., a multi-drug resistant bacterium infecting humans." International Journal of Systematic and Evolutionary Microbiology 70, no. 3 (2020): 1758–68. http://dx.doi.org/10.1099/ijsem.0.003968.

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We describe a new multidrug resistant Chitinophaga species that was isolated from patients with type 2 diabetes in Vietnam. Strain BD 01T was cultivated in 2017 from a blood sample of a patient suffering from bacteremia. Strain VP 7442 was isolated in 2018 from a pleural fluid sample of a patient who had presented with lung abscess and pleural effusion. Both strains are aerobic, Gram-negative, non-motile and non-spore-forming. The 16S rRNA gene sequences of both strains are 100 % similar and share a highest 16S sequence identity with Chitinophaga polysaccharea MRP-15T of 97.42 %. Their predominant fatty acid is iso-C15 : 0 (73.8 % for strain BD 01T and 79.8 % for strain VP 7442). The draft genome sizes of strains BD 01T and VP 7442 are 6 308 408 and 6 308 579 bp, respectively. They are resistant to beta-lactams, aminoglycosides, fluoroquinolones, metronidazole, fosfomycin, vancomycin and macrolides, and exhibit 20 and 18 antimicrobial resistance-related genes, respectively. Using the multiphasic taxonogenomic approach, we propose that strains BD 01T (=CSUR P9622=VTCC 70981) and VP 7442 (=CSUR P9623=VTCC 70982) represent a new species, for which we propose the name Chitinophaga vietnamensis sp. nov. Strain BD 01T was chosen as type strain of C. vietnamensis sp. nov.

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Sessitsch, Angela, Birgit Reiter, and Gabriele Berg. "Endophytic bacterial communities of field-grown potato plants and their plant-growth-promoting and antagonistic abilities." Canadian Journal of Microbiology 50, no. 4 (2004): 239–49. http://dx.doi.org/10.1139/w03-118.

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To study the effect of plant growth on potato-associated bacteria, the composition and properties of bacteria colonizing the endosphere of field-grown potato were analyzed by a multiphasic approach. The occurrence and diversity of potato-associated bacteria were monitored by a cultivation-independent approach, using terminal restriction fragment length polymorphism analysis of 16S rDNA. The patterns obtained revealed a high heterogeneity of community composition and suggested the existence of plant-specific communities. However, endophytic populations correlated to a certain extent with plant growth performance. Endophytes were also isolated from plants that grew well or grew poorly and were identified by partial sequencing of the 16S rRNA genes. A broad phylogenetic spectrum was found among isolates and differently growing plants hosted different bacterial populations. In an approach to investigate the plant-growth-promoting potential of potato-associated bacteria, a total of 35 bacteria were screened by dual testing for in vitro antagonism towards (i) the fungal pathogens Verticillium dahliae, Rhizoctonia solani, Sclerotinia sclerotiorum, and Phytophthora cactorum and (ii) the bacterial pathogens Erwinia carotovora, Streptomyces scabies, and Xanthomonas campestris. The proportion of isolates with antagonistic activity was highest against Streptomyces sp. (43%) followed by those against Xanthomonas sp. (29%). As all plants showed more or less severe disease symptoms of scab disease caused by Streptomyces scabies, we assume that the presence of the pathogen induced the colonization of antagonists. The antifungal activity of the isolates was generally low. The biotechnological potential of endophytic isolates assessed by their antagonistic activity and by in vitro production of enzymes, antibiotics, siderophores, and the plant growth hormone indole-1,3-acetic acid was generally high. Overall, seven endophytes were found to antagonize fungal as well as bacterial pathogens and showed a high production of active compounds and were therefore considered promising biological control agents.Key words: T-RFLP, 16S rRNA, siderophores, IAA, biocontrol.

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Henrich, Sören. "Gender identity assessment with trans individuals – findings of a systematic literature review of assessment instruments and ethical considerations." Journal of Criminological Research, Policy and Practice 6, no. 3 (2020): 203–16. http://dx.doi.org/10.1108/jcrpp-01-2020-0014.

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Purpose In several Western legislations, trans individuals must frequently undergo some form of gender identity assessment, for example, to receive legal recognition of their gender or to access therapeutic interventions. Thus, a standardised and empirically supported assessment approach becomes necessary. The purpose of this paper is to critically reflect on the current international guidelines for assessments by the World Professional Association for Transgender Health, which will be compared to standards in secure forensic settings, illustrated by British prison policies. Design/methodology/approach Findings of a systematic literature review following preferred reporting items for systematic reviews and meta-analysis standards are presented, summarising the current state of research pertaining to gender identity assessment instruments. Studies were included, when they presented empirical details pertaining to assessment approaches and passed the quality appraisal, but were excluded when they did not use a trans sample or presented clinical assessments not linked to gender identity. Findings A total of 21 included English articles, which mostly have been published in the USA in the past 20 years, propose ten different assessment approaches. Most of the studies support the use of the Minnesota Multiphasic Personality Inventory-2, the Bem Sex-Role Inventory, Body Image Scale for Transsexuals and the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults. The instruments are briefly summarised. Practical implications It becomes apparent that this field is severely understudied and that there is no consensus regarding the best assessment approach. Hence, any recommendations are only preliminary and are contextualised with further ethical considerations and suggestions for future research. Originality/value To the best of the author’s knowledge, this is the first systematic literature review pertaining to the (semi-)structured assessment of gender identity.

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Camu, Nicholas, Tom De Winter, Kristof Verbrugghe, et al. "Dynamics and Biodiversity of Populations of Lactic Acid Bacteria and Acetic Acid Bacteria Involved in Spontaneous Heap Fermentation of Cocoa Beans in Ghana." Applied and Environmental Microbiology 73, no. 6 (2007): 1809–24. http://dx.doi.org/10.1128/aem.02189-06.

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ABSTRACT The Ghanaian cocoa bean heap fermentation process was studied through a multiphasic approach, encompassing both microbiological and metabolite target analyses. A culture-dependent (plating and incubation, followed by repetitive-sequence-based PCR analyses of picked-up colonies) and culture-independent (denaturing gradient gel electrophoresis [DGGE] of 16S rRNA gene amplicons, PCR-DGGE) approach revealed a limited biodiversity and targeted population dynamics of both lactic acid bacteria (LAB) and acetic acid bacteria (AAB) during fermentation. Four main clusters were identified among the LAB isolated: Lactobacillus plantarum, Lactobacillus fermentum, Leuconostoc pseudomesenteroides, and Enterococcus casseliflavus. Other taxa encompassed, for instance, Weissella. Only four clusters were found among the AAB identified: Acetobacter pasteurianus, Acetobacter syzygii-like bacteria, and two small clusters of Acetobacter tropicalis-like bacteria. Particular strains of L. plantarum, L. fermentum, and A. pasteurianus, originating from the environment, were well adapted to the environmental conditions prevailing during Ghanaian cocoa bean heap fermentation and apparently played a significant role in the cocoa bean fermentation process. Yeasts produced ethanol from sugars, and LAB produced lactic acid, acetic acid, ethanol, and mannitol from sugars and/or citrate. Whereas L. plantarum strains were abundant in the beginning of the fermentation, L. fermentum strains converted fructose into mannitol upon prolonged fermentation. A. pasteurianus grew on ethanol, mannitol, and lactate and converted ethanol into acetic acid. A newly proposed Weissella sp., referred to as “Weissella ghanaensis,” was detected through PCR-DGGE analysis in some of the fermentations and was only occasionally picked up through culture-based isolation. Two new species of Acetobacter were found as well, namely, the species tentatively named“ Acetobacter senegalensis” (A. tropicalis-like) and “Acetobacter ghanaensis” (A. syzygii-like).

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Fadeev, Filip, Anton Eremeev, Farid Bashirov, et al. "Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs." Brain Sciences 10, no. 10 (2020): 744. http://dx.doi.org/10.3390/brainsci10100744.

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This study evaluates the effect of combined epidural electrical stimulation (EES) applied above (C5) and below (L2) the spinal cord injury (SCI) at T8–9 combined with motor training on the restoration of sensorimotor function in mini pigs. The motor evoked potentials (MEP) induced by EES applied at C5 and L2 levels were recorded in soleus muscles before and two weeks after SCI. EES treatment started two weeks after SCI and continued for 6 weeks led to improvement in multiple metrics, including behavioral, electrophysiological, and joint kinematics outcomes. In control animals after SCI a multiphasic M-response was observed during M/H-response testing, while animals received EES-enable training demonstrated the restoration of the M-response and H-reflex, although at a lower amplitude. The joint kinematic and assessment with Porcine Thoracic Injury Behavior scale (PTIBS) motor recovery scale demonstrated improvement in animals that received EES-enable training compared to animals with no treatment. The positive effect of two-level (cervical and lumbar) epidural electrical stimulation on functional restoration in mini pigs following spinal cord contusion injury in mini pigs could be related with facilitation of spinal circuitry at both levels and activation of multisegmental coordination. This approach can be taken as a basis for the future development of neuromodulation and neurorehabilitation therapy for patients with spinal cord injury.

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Carvalho, Lucas de Francisco, Giselle Pianowski, and Ana Maria Reis. "Development and Diagnostic Accuracy of the Screening of the Dimensional Clinical Personality Inventory." Psicologia: Ciência e Profissão 37, no. 4 (2017): 1011–24. http://dx.doi.org/10.1590/1982-3703003082016.

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Abstract: The assessment of personality disorders assumes unquestioned clinical relevance when considering the prevalence rates in the general population. Tests assessing the typical pathological traits of these disorders has been adapted to and developed in Brazil. However, there is a gap in the country of screening tools for personality disorders. Screening tools are designed to allow a fast and informative application on the likelihood of a positive diagnosis, where the consequence should be conveyed to a diagnostic assessment. Using as a base the Dimensional Clinical Personality Inventory (IDCP), developed at the national level, the objective of this research was to develop a screening tool for personality disorders, as well as investigate its diagnostic accuracy. The study included 1,196 people, aging between 18 and 73 years (M = 26.32, SD = 8.69), and 64.1% female. The sample was divided into clinical and non-clinical group. We used an empirical approach based on criteria for selection of items similar to those adopted in the development of Minnesota Multiphasic Personality Inventory was used (MMPI). The logistic regression analysis and also the calculation of Cohen's d indicated the items that best discriminate against people with personality disorders and those without this diagnosis. We achieved a final set of 15 items with satisfactory sensitivity and specificity for screening test. We discusses the strengths and limitations of screening version of the IDCP and guidelines for further study.

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Winkel, David J., Hanns-Christian Breit, Thomas J. Weikert, and Bram Stieltjes. "Building Large-Scale Quantitative Imaging Databases with Multi-Scale Deep Reinforcement Learning: Initial Experience with Whole-Body Organ Volumetric Analyses." Journal of Digital Imaging 34, no. 1 (2021): 124–33. http://dx.doi.org/10.1007/s10278-020-00398-y.

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AbstractTo explore the feasibility of a fully automated workflow for whole-body volumetric analyses based on deep reinforcement learning (DRL) and to investigate the influence of contrast-phase (CP) and slice thickness (ST) on the calculated organ volume. This retrospective study included 431 multiphasic CT datasets—including three CP and two ST reconstructions for abdominal organs—totaling 10,508 organ volumes (10,344 abdominal organ volumes: liver, spleen, and kidneys, 164 lung volumes). Whole-body organ volumes were determined using multi-scale DRL for 3D anatomical landmark detection and 3D organ segmentation. Total processing time for all volumes and mean calculation time per case were recorded. Repeated measures analyses of variance (ANOVA) were conducted to test for robustness considering CP and ST. The algorithm calculated organ volumes for the liver, spleen, and right and left kidney (mean volumes in milliliter (interquartile range), portal venous CP, 5 mm ST: 1868.6 (1426.9, 2157.8), 350.19 (45.46, 395.26), 186.30 (147.05, 214.99) and 181.91 (143.22, 210.35), respectively), and for the right and left lung (2363.1 (1746.3, 2851.3) and 1950.9 (1335.2, 2414.2)). We found no statistically significant effects of the variable contrast phase or the variable slice thickness on the organ volumes. Mean computational time per case was 10 seconds. The evaluated approach, using state-of-the art DRL, enables a fast processing of substantial amounts irrespective of CP and ST, allowing building up organ-specific volumetric databases. The thus derived volumes may serve as reference for quantitative imaging follow-up.

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Gjoreski, Aleksandar, Ivona Jovanoska, Gjorgi Dungevski, Nikola Lazovski, and Menka Lazareska. "Urgent Endovascular Treatment of Iliac Artery Pseudoaneurysm in Patient with Ehlers-Danlos Syndrome: A Case Report." Open Access Macedonian Journal of Medical Sciences 8, no. C (2020): 156–60. http://dx.doi.org/10.3889/oamjms.2020.5348.

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BACKGROUND: Ehlers-Danlos syndrome (EDS) type IV is a heritable disorder of connective tissue that is mainly associated with vascular maladies such as aneurysms, pseudoaneurysms, and dissections with or without spontaneous rupture. Historically, vascular complications in EDS IV have been treated conservatively whenever possible, due to the high morbidity and mortality after vascular interventions, whether open or endovascular. We present a case of a ruptured pseudoaneurysm of the right common iliac artery in a 18-year-old male, who was successfully treated by endovascular approach and later diagnosed with EDS type IV. CASE PRESENTATION: A 18-year-old male patient was admitted in ER with sharp pain in the right hypogastrium, hypotensive and with reduced blood parameters. Multiphasic modern computed tomography (MDCT) scan of abdomen and pelvis revealed massive ride sided pelvic and retroperitoneal hematoma. The presence of pseudoaneurysms on both common iliac arteries (CIA) was detected, with small ulcer on the right side and a focal dissection on the left side. An urgent endovascular repair of the ruptured pseudoaneurysm on the right CIA with covered stent was performed. Patient’s laboratory parameters and clinical status improved significantly within the next few days. CONCLUSIONS: Vascular repair in EDS-IV patients carries significant risk and should be indicated very carefully. Endovascular treatment for these patients is feasible and should be considered as an alternative to open surgery in some challenging cases as this one.

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