Relevant bibliographies by topics / Mutation-tolerant

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Academic literature on the topic 'Mutation-tolerant'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Mutation-tolerant"

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Pevzner, Pavel A., Vlado Dančík, and Chris L. Tang. "Mutation-Tolerant Protein Identification by Mass Spectrometry." Journal of Computational Biology 7, no. 6 (December 2000): 777–87. http://dx.doi.org/10.1089/10665270050514927.

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S., Arivarasan. "A New Modified Mutation based Ant Colony Algorithm for Optimized Fault Tolerant Routing Protocol in MANET." Journal of Advanced Research in Dynamical and Control Systems 12, SP3 (February 28, 2020): 242–55. http://dx.doi.org/10.5373/jardcs/v12sp3/20201259.

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Yunita, Rossa, Nurul Khumaida, Didy Sopandie, and Ika Mariska. "SOMACLONAL PUTATIVE MUTANTS OF RICE TOLERANT TO SALINITY." Indonesian Journal of Agricultural Science 19, no. 2 (December 9, 2018): 67. http://dx.doi.org/10.21082/ijas.v19n2.2018.p67-74.

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<p class="abstrakinggris">Soil salinity could significantly reduce rice yield, therefore, varieties tolerant to salinity are urgent to be developed. Mutation induction could be used to create rice mutants tolerant to salinity. The study aimed to evaluate the tolerance of somaclonal mutants of rice to NaCl salinity in a greenhouse condition and characterize their tolerance mechanism. A total of 45 putative mutants were generated by a gamma ray mutation induction followed with <em>in vitro</em> selection in the growth media containing different NaCl concentrations in the greenhouse experiment. The study consisted of two-factor treatments, namely three levels of NaCl concentrations and 45 rice mutants suspected to be tolerant to salinity, arranged in a completely randomized design. Proline, cations (K, Na, Ca, and Mg) content, and stomata density were evaluated. The results showed that eight mutants were tolerant to 150 mM NaCl, namely CH30, CH-4-2, II-13-42, II-13-7, II-13-10, II-13-13, II-13- 2, and IA-3-21. These tolerant mutants had a higher Na content compared to the check parent. The tolerant mutants had a high proline content, lower Na, and stable K, Mg and Ca cations as well as had a greater number of stomata and higher stomata length-width ratio. Some of the identified tolerant mutants demonstrated the tolerant mechanism against salinity stress. Further studies are required to evaluate these tolerant mutants in the field conditions under salinity stress.</p>
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Tulmann Neto, Augusto, Marcelo Correa Alves, Carlos Eduardo de Oliveira Camargo, Jairo Lopes de Castro, and Wilson Penteado Ferreira Filho. "New wheat genotypes tolerant to aluminum toxicity obtained by mutation induction." Pesquisa Agropecuária Brasileira 36, no. 1 (January 2001): 61–70. http://dx.doi.org/10.1590/s0100-204x2001000100008.

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Seed from the sensitive wheat (Triticum aestivumL.) cultivar Anahuac was treated to gamma-ray irradiation and eleven Al3+ tolerant mutants selected. The objective was to compare these mutants to the original Anahuac and to the tolerant wheat cultivars IAC-24 and IAC-60 from 1994 to 1996 in acid (Capão Bonito) and limed (Monte Alegre do Sul) soil field trials, in the State of São Paulo, Brazil. Grain yield and agronomic characteristics were analyzed. All the mutant lines yielded higher than the sensitive Anahuac cultivar in the acid soils of Capão Bonito. Under limed soil conditions, 10 mutants had a similar yield to the original sensitive cultivar and one a lower yield. The majority of the mutants were similar in yield to the tolerant cultivars IAC-24 and IAC-60 under both conditions. Some of the mutants showed altered agronomic characteristics, but these alterations did not generally influence the grain yield. The results indicated that tolerant lines with good characteristics may be obtained from a susceptible cultivar by mutation induction, thus allowing cropping under conditions where Al3 + is a limiting factor.
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Çelik, Özge, Aybüke Ekşioğlu, and Enes Yağız Akdaş. "Transcript profiling of salt tolerant tobacco mutants generated via mutation breeding." Gene Expression Patterns 29 (September 2018): 59–64. http://dx.doi.org/10.1016/j.gep.2018.05.001.

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Li, Xian-Zhi, and Keith Poole. "Organic solvent-tolerant mutants of Pseudomonas aeruginosa display multiple antibiotic resistance." Canadian Journal of Microbiology 45, no. 1 (January 1, 1999): 18–22. http://dx.doi.org/10.1139/w98-127.

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Organic solvent-tolerant mutants of Pseudomonas aeruginosa selected in the presence of hexane exhibited increased resistance to a variety of structurally unrelated antimicrobial agents, including beta-lactams, fluoroquinolones, chloramphenicol, tetracycline, and novobiocin, a phenotype typical of nalB multidrug-resistant mutants. Western immunoblotting with antibodies specific to components of the three known multidrug efflux systems in P. aeruginosa demonstrated that the solvent-tolerant mutants displayed increased expression of the MexAB-OprM system and decreased expression of the MexEF-OprN system. Sequence analysis of mexR, the repressor gene of mexAB-oprM efflux operon, identified a nonsense mutation and a point mutation in the mexR genes of two solvent-tolerant mutants. These results emphasize the importance of the MexAB-OprM efflux system in organic solvent tolerance and the ability of environmental pollutants to select bacteria with a medically relevant antibiotic-resistant phenotype.Key words: Pseudomonas aeruginosa, organic solvent tolerance, multidrug resistance, MexAB-OprM efflux pump, mexR gene.
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Matsui, Ken, Shinya Teranishi, Shohei Kamon, Kouichi Kuroda, and Mitsuyoshi Ueda. "Discovery of a Modified Transcription Factor Endowing Yeasts with Organic-Solvent Tolerance and Reconstruction of an Organic-Solvent-Tolerant Saccharomyces cerevisiae Strain." Applied and Environmental Microbiology 74, no. 13 (May 9, 2008): 4222–25. http://dx.doi.org/10.1128/aem.02874-07.

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ABSTRACT Organic-solvent tolerance in Saccharomyces cerevisiae strain KK-211, which was first isolated as an organic-solvent-tolerant strain, depends on point mutation (R821S) of the transcription factor Pdr1p. The integration of the PDR1 R821S mutation into wild-type yeast results in organic-solvent tolerance, and the PDR1 R821S mutant can reduce carbonyl compounds in organic solvents.
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Castellanos-Rizaldos, E., Pingfang Liu, Coren A. Milbury, Minakshi Guha, Angela Brisci, Laura Cremonesi, Maurizio Ferrari, Harvey Mamon, and G. Mike Makrigiorgos. "Temperature-Tolerant COLD-PCR Reduces Temperature Stringency and Enables Robust Mutation Enrichment." Clinical Chemistry 58, no. 7 (July 1, 2012): 1130–38. http://dx.doi.org/10.1373/clinchem.2012.183095.

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Abstract BACKGROUND Low-level mutations in clinical tumor samples often reside below mutation detection limits, thus leading to false negatives that may impact clinical diagnosis and patient management. COLD-PCR (coamplification at lower denaturation temperature PCR) is a technology that magnifies unknown mutations during PCR, thus enabling downstream mutation detection. However, a practical difficulty in applying COLD-PCR has been the requirement for strict control of the denaturation temperature for a given sequence, to within ±0.3 °C. This requirement precludes simultaneous mutation enrichment in sequences of substantially different melting temperature (Tm) and limits the technique to a single sequence at a time. We present a temperature-tolerant (TT) approach (TT-COLD-PCR) that reduces this obstacle. METHODS We describe thermocycling programs featuring a gradual increase of the denaturation temperature during COLD-PCR. This approach enabled enrichment of mutations when the cycling achieves the appropriate critical denaturation temperature of each DNA amplicon that is being amplified. Validation was provided for KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) and TP53 (tumor protein p53) exons 6–9 by use of dilutions of mutated DNA, clinical cancer samples, and plasma-circulating DNA. RESULTS A single thermocycling program with a denaturation-temperature window of 2.5–3.0 °C enriches mutations in all DNA amplicons simultaneously, despite their different Tms. Mutation enrichments of 6–9-fold were obtained with TT-full-COLD-PCR. Higher mutation enrichments were obtained for the other 2 forms of COLD-PCR, fast-COLD-PCR, and ice-COLD-PCR. CONCLUSIONS Low-level mutations in diverse amplicons with different Tms can be mutation enriched via TT-COLD-PCR provided that their Tms fall within the denaturation-temperature window applied during amplification. This approach enables simultaneous enrichment of mutations in several amplicons and increases significantly the versatility of COLD-PCR.
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Schneiders, T., S. G. B. Amyes, and S. B. Levy. "Role of AcrR and RamA in Fluoroquinolone Resistance in Clinical Klebsiella pneumoniae Isolates from Singapore." Antimicrobial Agents and Chemotherapy 47, no. 9 (September 2003): 2831–37. http://dx.doi.org/10.1128/aac.47.9.2831-2837.2003.

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ABSTRACT The MICs of ciprofloxacin for 33 clinical isolates of K. pneumoniae resistant to extended-spectrum cephalosporins from three hospitals in Singapore ranged from 0.25 to >128 μg/ml. Nineteen of the isolates were fluoroquinolone resistant according to the NCCLS guidelines. Strains for which the ciprofloxacin MIC was ≥0.5 μg/ml harbored a mutation in DNA gyrase A (Ser83→Tyr, Leu, or IIe), and some had a secondary Asp87→Asn mutation. Isolates for which the MIC was 16 μg/ml possessed an additional alteration in ParC (Ser80→IIe, Trp, or Arg). Tolerance of the organic solvent cyclohexane was observed in 10 of the 19 fluoroquinolone-resistant strains; 3 of these were also pentane tolerant. Five of the 10 organic solvent-tolerant isolates overexpressed AcrA and also showed deletions within the acrR gene. Complementation of the mutated acrR gene with the wild-type gene decreased AcrA levels and produced a two- to fourfold reduction in the fluoroquinolone MICs. None of the organic solvent-tolerant clinical isolates overexpressed another efflux-related gene, acrE. While marA and soxS were not overexpressed, another marA homologue, ramA, was overexpressed in 3 of 10 organic solvent-tolerant isolates. These findings indicate that multiple target and nontarget gene changes contribute to fluoroquinolone resistance in K. pneumoniae. Besides AcrR mutations, ramA overexpression (but not marA or soxS overexpression) was related to increased AcrAB efflux pump expression in this collection of isolates.
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Liu, Rongxiang, Jing Zhao, Zhongrui Xu, and Zhiting Xiong. "Comparison and Characterization of a Cell Wall Invertase Promoter from Cu-Tolerant and Non-Tolerant Populations of Elsholtzia haichowensis." International Journal of Molecular Sciences 22, no. 10 (May 18, 2021): 5299. http://dx.doi.org/10.3390/ijms22105299.

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Cell wall invertase (CWIN) activity and the expression of the corresponding gene were previously observed to be significantly elevated in a Cu-tolerant population of Elsholtzia haichowensis relative to a non-tolerant population under copper stress. To understand the differences in CWIN gene regulation between the two populations, their CWIN promoter β-glucuronidase (GUS) reporter vectors were constructed. GUS activity was measured in transgenic Arabidopsis in response to copper, sugar, and phytohormone treatments. Under the copper treatment, only the activity of the CWIN promoter from the Cu-tolerant population was slightly increased. Glucose and fructose significantly induced the activity of CWIN promoters from both populations. Among the phytohormone treatments, only salicylic acid induced significantly higher (p < 0.05) activity of the Cu-tolerant CWIN promoter relative to the non-tolerant promoters. Analysis of 5′-deletion constructs revealed that a 270-bp promoter fragment was required for SA induction of the promoter from the Cu-tolerant population. Comparison of this region in the two CWIN promoters revealed that it had 10 mutation sites and contained CAAT-box and W-box cis-elements in the Cu-tolerant promoter only. This work provides insights into the regulatory role of SA in CWIN gene expression and offers an explanation for differences in CWIN expression between E. haichowensis populations.
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Dissertations / Theses on the topic "Mutation-tolerant"

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Wang, Yun. "Development of acetic-acid tolerant Zymomonas mobilis strains through adaptation." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29747.

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Thesis (M. S.)--Chemical Engineering, Georgia Institute of Technology, 2008.
Committee Chair: Dr. Rachel Chen; Committee Member: Dr. Athanassios Sambanis; Committee Member: Dr. Sankar Nair. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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"Engineering Mutation-Tolerant Genes." Master's thesis, 2019. http://hdl.handle.net/2286/R.I.53958.

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abstract: Ideas from coding theory are employed to theoretically demonstrate the engineering of mutation-tolerant genes, genes that can sustain up to some arbitrarily chosen number of mutations and still express the originally intended protein. Attention is restricted to tolerating substitution mutations. Future advances in genomic engineering will make possible the ability to synthesize entire genomes from scratch. This presents an opportunity to embed desirable capabilities like mutation-tolerance, which will be useful in preventing cell deaths in organisms intended for research or industrial applications in highly mutagenic environments. In the extreme case, mutation-tolerant genes (mutols) can make organisms resistant to retroviral infections. An algebraic representation of the nucleotide bases is developed. This algebraic representation makes it possible to convert nucleotide sequences into algebraic sequences, apply mathematical ideas and convert results back into nucleotide terms. Using the algebra developed, a mapping is found from the naturally-occurring codons to an alternative set of codons which makes genes constructed from them mutation-tolerant, provided no more than one substitution mutation occurs per codon. The ideas discussed naturally extend to finding codons that can tolerate t arbitrarily chosen number of mutations per codon. Finally, random substitution events are simulated in both a wild-type green fluorescent protein (GFP) gene and its mutol variant and the amino acid sequence expressed from each post-mutation is compared with the amino acid sequence pre-mutation. This work assumes the existence of synthetic protein-assembling entities that function like tRNAs but can read k nucleotides at a time, with k greater than or equal to 5. The realization of this assumption is presented as a challenge to the research community.
Dissertation/Thesis
Masters Thesis Biomedical Engineering 2019
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Wang, Szu-Ying, and 王思穎. "Evaluating the feasibility of H2 production in ammonium-rich medium with ammonium-tolerant Rhodospeudomonas palustris WP3-5 improved by NifA mutation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/bd32uu.

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碩士
國立中興大學
環境工程學系所
101
Hydrogen is a clean alternative energy. The advantage of hydrogen is only produce energy and water after burning, and it has high energy content (122kJ/g). Hydrogen can be produced by physical, chemical or biological process. Purple non-sulfur bacteria (PNSB) is the major microbial group to produce hydrogen. The mechanism of PNSB to produce hydrogen is mainly mediated through nitrogenase, evolved to catalyze nitrogen fixation. Nitrogenase expression is regulated by NifA, which is a nitrogenase activator. However, NifA activity is affected by ammonium concentration. The high ammonium concentration can inhibit NifA activity, therefore it can’t regulate the gene, which related nitrogenase, to transcription, and nitrogenase can not be expressed. In this study, a R. palustris NifAnQ 24 mutant with an in-frame deletion of the Q region of chromosomal nifA gene was constructed from R. palustris WP3-5 to overcome the inhibition of nitrogenase activity by ammonium. A series of ammonium-rich mediums with acetate or lactate as carbon sources and ammonium chloride or glutamate as nitrogen sources were used to compare the hydrogen production between the wild-type strain WP3-5 and the mutant strain NifAnQ 24. The result showed that, hydrogen production of NifAnQ 24 was not significantly different from WP3-5 in glutamate-contained medium, indicated that nitrogenase expression were not affected in NifAnQ 24. On the other hand, WP3-5 could produce hydrogen only when the ammonium chloride in medium was below 0.9 mM, while NifAnQ 24 could produce hydrogen in the medium when ammonium chloride concentration was 7.5, 18.7, and 28.0 mM with acetate or lactate as carbon source. In the medium with lactate as carbon source and rich in ammonium, the NifAnQ 24 SHPR was 97.36 mL-H2/g-biomass/day, and SCE is 27.8%. The result showed that NifAnQ 24 could successfully produce hydrogen by photo fermetation in ammonium rich medium. The possibility of increasing more carbon source distribution to hydrogen production than to growth by increasing initial cell concentration was also evaluated. The results indicated that, the hydrogen production of NifAnQ 24 couldn’t be improved by high initial cell concentration.
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Book chapters on the topic "Mutation-tolerant"

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Vanèetoviæ, J., M. Simiæ, and S. Božinoviæ. "10. The use of CTM (cycloxydim tolerant maize) mutation in maize weeds control." In Mutagenesis: exploring novel genes and pathways, 203–14. The Netherlands: Wageningen Academic Publishers, 2014. http://dx.doi.org/10.3920/978-90-8686-787-5_10.

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Das, P., M. Mishra, N. Lakra, S. L. Singla-Pareek, and A. Pareek. "1. Mutation breeding: a powerful approach for obtaining abiotic stress tolerant crops and upgrading food security for human nutrition." In Mutagenesis: exploring novel genes and pathways, 15–36. The Netherlands: Wageningen Academic Publishers, 2014. http://dx.doi.org/10.3920/978-90-8686-787-5_1.

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Conference papers on the topic "Mutation-tolerant"

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Pevzner, Pavel A., Vlado Dančík, and Chris L. Tang. "Mutation-tolerant protein identification by mass-spectrometry." In the fourth annual international conference. New York, New York, USA: ACM Press, 2000. http://dx.doi.org/10.1145/332306.332560.

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Reports on the topic "Mutation-tolerant"

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Ulukapi, Kamile, and Ayse Gul Nasircilar. Mutation Breeding Protocol for Development of Drought-tolerant Genotypes in Phaseolus vulgaris L. Using in-vitro Embryo Culture Techniques. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, November 2020. http://dx.doi.org/10.7546/crabs.2020.11.10.

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