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Journal articles on the topic 'N-acyl derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kaválek, Jaromír, Josef Jirman, and Vojeslav Štěrba. "Kinetics and mechanism of rearrangement and methanolysis of acylphenylthioureas." Collection of Czechoslovak Chemical Communications 50, no. 3 (1985): 766–78. http://dx.doi.org/10.1135/cccc19850766.

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S-Acyl-1-phenylthioureas and their 3-methyl derivatives are rearranged to 1-acyl derivatives of thiourea in methanolic solution. The rearrangement of the 1-acyl-1-phenyl derivative to the thermodynamically more stable 3-acyl derivative is subject to specific base catalysis. The rearrangement of acetyl group is about 2 orders of magnitude slower than that of benzoyl group. 1-Acetyl-l-phenylthiourea undergoes base-catalyzed methanolysis (giving phenylthiourea and methyl acetate) instead of the rearrangement. The methanolysis rates of l-acyl-3-phenylthioureas and their N-methyl derivatives have b

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2

Romanov, V. E., E. E. Shul’ts, M. M. Shakirov, and G. A. Tolstikov. "New acyl derivatives of N-deacetyllappaconitine." Chemistry of Natural Compounds 44, no. 3 (2008): 346–51. http://dx.doi.org/10.1007/s10600-008-9058-3.

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3

Kutschy, Peter, Milan Dzurilla, Vlastimír Ficeri, and Dušan Koščík. "New Synthesis of N-Acylurea Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 3 (1993): 575–87. http://dx.doi.org/10.1135/cccc19930575.

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S-Allyl N-acylmonothiocarbamates react in boiling benzene with primary and secondary amines in the presence of catalytic amounts of triethylamine. In this reaction, the S-allyl group is replaced with the amino group under formation of N-acylurea derivatives in 45 - 90% yields. The wide applicability of the reaction is demonstrated by the synthesis of eighty four N-acyl-N'-substituted and N-acyl-N',N'-disubstituted ureas with various aliphatic, aromatic and heterocyclo substituents.

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4

Mangroo, Dev, and Gerhard E. Gerber. "Synthesis of acyl-CoA thioesters." Biochemistry and Cell Biology 68, no. 1 (1990): 308–12. http://dx.doi.org/10.1139/o90-042.

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An improved synthesis of fatty acyl coenzyme A has been developed that permits the synthesis of highly radioactive fatty acyl coenzyme A derivatives and thus can be used for the synthesis of high specific activity photoaffinity labels. Conditions were developed to solubilize the coenzyme A in anhydrous solvent for the acylation. The complete activation of fatty acid to the imidazolide is described and the acylation of the coenzyme A under anhydrous conditions was shown to result in the conversion of the fatty acid to the fatty acyl coenzyme A derivative. The synthetic product was shown by its

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5

Hirano, Shigehiro, Ken-ichiro Hayashi, and Keiji Hirochi. "Some N -acyl derivatives of O -carboxymethylchitosan." Carbohydrate Research 225, no. 1 (1992): 175–78. http://dx.doi.org/10.1016/0008-6215(92)80052-3.

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6

Isobaev, M. D., and E. Kh Pulatov. "N-Acyl andN-sulfonyl derivatives of thiazolidines." Russian Chemical Bulletin 45, no. 12 (1996): 2820–22. http://dx.doi.org/10.1007/bf01430651.

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7

Kochetkov, K. A., Zh S. Urmambetova, V. M. Belikov, and Z. B. Bakasova. "Higher N-acyl-L-amino acid derivatives." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 39, no. 11 (1990): 2311–16. http://dx.doi.org/10.1007/bf00958844.

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8

Zosimo-Landolfo, Guido, Jean M. J. Tronchet, and Ford Habashi. "N- and O-acyl derivatives of Deoxy-N-hydroxyaminosugars." Journal f�r Praktische Chemie/Chemiker-Zeitung 336, no. 3 (1994): 273–76. http://dx.doi.org/10.1002/prac.19943360318.

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9

Dang, Chi-Hien, Cong-Hao Nguyen, Thanh-Danh Nguyen, and Chan Im. "Synthesis and characterization of N-acyl-tetra-O-acyl glucosamine derivatives." RSC Advances 4, no. 12 (2014): 6239. http://dx.doi.org/10.1039/c3ra46007j.

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10

Sawada, S., T. Yokokura, and T. Miyasaka. "Synthesis and Antitumor Activity of A-Ring or E-Lactone Modified Water Soluble Prodrugs of 20(S)-Camptothecin, Including Development of Irinotecan Hydrochloride Trihydrate (CPT-11)." Current Pharmaceutical Design 1, no. 1 (1995): 113–32. http://dx.doi.org/10.2174/1381612801666220524193614.

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Camptothecin was converted into derivatives which have substituents on the A- and B rings . One potent and less toxic derivative , 7-ethyl-10-hydroxycamp-tothecin (SN-38), was selected and then converted into glycosides, sulfates, phosphates and carbamates at the 10-hydroxyl group. Among these water-soluble, E-lactone-intact derivatives , the hydrochloride trihydrate of 7-ethyl-10 - [(4-piperidinopiperidine )carbony loxy]camptothecin(irinotecan hydrochloride trihydrate , CPT-11) had a broad spectrum of antitumor activity and seems to be a promising anticancer agent with a new mode of action.

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11

Panea, I., Lucia Bodochi, Teodora Panea, Daniela Zinveliu, and Violeta Pascalau. "BIOLOGICAL ACTIVE ACYLHYDRAZIDE I. THE O-ACYL-DERIVATIVES NATURE OF MONOACYLATION PRODUCTS OF CYCLIC MALEIC- AND PHTHALIC-HYDRAZIDE." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 7, no. 8 (1999): 25–40. http://dx.doi.org/10.48141/sbjchem.v7.n8.1999.27_1999.pdf.

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We confirmed, on the basis of chemical and physicochemical (melting points, IR- and 1H-NMR-spectra) data, that the products isolated by monoacylation of cyclic maleic- and phthalic-hydrazides have only the O-acyl derivatives nature although owing to tautomerism. These hydrazides may give rise to N- or/and O-acyl derivatives in such reactions. Simultaneously, we showed that the claims for the obtainment of N-acyl derivatives of cyclic maleic- and phthalic-hydrazides were not valid. Also by reacting the cyclic maleic-, respectively phthalic-hydrazide, with 4-chlorobenzoylchloride two new O-monoa

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12

Abdelhamid, Abdou Osman, and A. S. Shawali. "Synthesis of Some New 2-Imino-2,3-dihydro-1,3,4-thiadiazole and Selenadiazole Derivatives." Zeitschrift für Naturforschung B 42, no. 5 (1987): 613–16. http://dx.doi.org/10.1515/znb-1987-0516.

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(2)Diazotized 3(5)amino-5(3)-phenylpyrazole reacts with phenacylthiocyanate (1) and phenacylselenocyanate (10) to give the corresponding 1,3,4-thiadiazoline derivative (5) and 1,3,4- selenadiazoline derivative (12), respectively. A mechanism is proposed and it is substantiated by an alternate synthesis of 5 and 12 from the corresponding hydrazidoyl bromide (6) with potassium thiocyanate and potassium selenocyanate, respectively. The thiadiazoline (5) and selenadiazoline (12) give the respective N-acyl derivatives (7a) and (12) with acetic anhydride. Nitrosation of 5 and 12 gives the correspond

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13

Kahns, Anne H., and Hans Bundgaard. "N-Acyl derivatives as prodrug forms for amides: Chemical stability and enzymatic hydrolysis of various N-acyl and N-alkoxycarbonyl amide derivatives." International Journal of Pharmaceutics 71, no. 1-2 (1991): 31–43. http://dx.doi.org/10.1016/0378-5173(91)90065-v.

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14

Rekatas, George V., Vassilis J. Demopoulos, and Panos N. Kourounakis. "Synthesis ofN-acyl-2-pyrrolidinones from the corresponding N-acyl-GABA derivatives." Journal of Heterocyclic Chemistry 33, no. 3 (1996): 989–90. http://dx.doi.org/10.1002/jhet.5570330372.

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15

Wallach, J., F. Peypoux, O. Lapr�vote, and M. Pagadoy. "N -Acyl derivatives of Asn, new bacterial N -acyl D -amino acids with surfactant activity." Amino Acids 26, no. 2 (2004): 209–14. http://dx.doi.org/10.1007/s00726-003-0056-2.

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16

REKATAS, G. V., V. J. DEMOPOULOS, and P. N. KOUROUNAKIS. "ChemInform Abstract: Synthesis of N-Acyl-2-pyrrolidinones from the Corresponding N-Acyl- GABA Derivatives." ChemInform 27, no. 50 (2010): no. http://dx.doi.org/10.1002/chin.199650102.

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17

Saadi, Lina, and Shaimaa Adnan. "Synthesis, Antibacterial and Antioxidant Evaluation of 2-Substituted-4-arylidene-5(4<i>H</i>)-oxazolone Derivatives." Indonesian Journal of Chemistry 23, no. 5 (2023): 1463. http://dx.doi.org/10.22146/ijc.83052.

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In this research, the synthesis of new substituted oxazolone derivatives is described via Erlenmeyer synthesis of N-acyl amino acid. Firstly, the azo derivative 1 was prepared by coupling the diazonium salt of 3-amino-4-methoxybenzoic acid with 4,5-dichloroimidazole in sodium hydroxide solution. Benzoyl chloride derivative 2, the key intermediate of the synthesis, was synthesized by the acylation of azo-carboxylic acid derivative 1 with thionyl chloride. The resulting acyl chloride derivative reacted with glycine in a basic catalyst to form a hippuric acid derivative 3. After that, oxazolone d

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18

ISOBAEV, M. D., and E. KH PULATOV. "ChemInform Abstract: N-Acyl and N-Sulfonyl Derivatives of Thiazolidine." ChemInform 28, no. 23 (2010): no. http://dx.doi.org/10.1002/chin.199723151.

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19

Cablewski, Teresa, Craig L. Francis, and Andris J. Liepa. "N, N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. V The Preparation of some Benzimidazo-Fused [1,2,4,6]Thiatriazine Dioxides." Australian Journal of Chemistry 61, no. 1 (2008): 59. http://dx.doi.org/10.1071/ch07336.

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N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 were treated with 2-aminobenzimidazoles 2 to give [1,2,4,6]thiatriazino[2,3-a]benzimidazole 1,1-dioxides 3 and [1,2,4,6]thiatriazino[4,3-a]benzimidazole 2,2-dioxides 4. Some N-alkyl-, N-acyl-, and N-sulfonyl-derivatives of 3 were prepared. These products are derivatives of rare heterocycles.

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20

Hashimoto, Kazuhiko, Hiroshi Sumitomo, and Atsuko Washio. "Aminolysis of N-Acyl Derivatives of Bicyclic Oxalactams." Polymer Journal 20, no. 8 (1988): 615–25. http://dx.doi.org/10.1295/polymj.20.615.

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21

Morley, J. A., and L. Elrod. "Determination of fluoroquinolone antibacterials as N-acyl derivatives." Chromatographia 37, no. 5-6 (1993): 295–99. http://dx.doi.org/10.1007/bf02278637.

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22

Persson, T., A. B. Hörnfeldt, S. Gronowitz та N. G. Johansson. "Synthesis of Mimics to 5-(2″-thienyl)-2′,3′-β-Dideoxyuridine Triphosphate". Antiviral Chemistry and Chemotherapy 7, № 2 (1996): 101–7. http://dx.doi.org/10.1177/095632029600700207.

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A series of 5′-amido derivatives of 5-(2″-thienyl)-2′,3′,5′-β-trideoxyuridine were prepared. The compounds were tested for their inhibition of cellular DNA polymerase α and α HIV-RT. The succinic fumaric and maleic acid derivatives of 5-(2″-thienyl)-2′,3′,5′-β-trideoxyuridine were investigated. None of the compounds inhibited HIV-RT. The fumaric acid derivative inhibited DNA pol α with IC50 33 μg ml−1. The succinic acid derivative was about half as active with IC50 76 μg ml−1. The 5′-N-acyl derivatives also were structurally compared to the monomethyl ester of the triphosphate using the Sybyl

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23

Bain, Alex D., Hao Chen, and Paul H. M. Harrison. "Studies of structure and dynamics in a nominally symmetric twisted amide by NMR and electronic structure calculations." Canadian Journal of Chemistry 84, no. 3 (2006): 421–28. http://dx.doi.org/10.1139/v06-016.

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Amides that are twisted around the C—N bond show unusual spectroscopy and reactivity when compared with planar amides. The diacyl derivatives of 3,4,7,8-tetramethyl-2,5-dithioglycoluril are intriguing examples of this class, since the crystal structures show that the two acyl groups are twisted by different amounts on either side of the molecule owing to a combination of steric and electronic effects. However, the 1H NMR spectra in solution at room temperature exhibit only one acyl resonance, so there must be fast interconversion among pairs of equivalent structures of each compound. We have p

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24

Sulaiman, Ahmed T., and Susan W. Sarsam. "Synthesis, Characterization and Antibacterial Activity Evaluation of New Indole-Based Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 207–2015. http://dx.doi.org/10.31351/vol29iss1pp207-2015.

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A new series of N-acyl hydrazones (4a-g) derived from indole-3-propionic acid (IPA) were synthesized. These N-acyl hydrazones were prepared by the reaction of 3-(1H-indol-3-yl) propane hydrazide and aldehyde in the existence of glacial acetic acid as a catalyst. 1HNMR and FT-IR analyses were used to identify the synthesized compounds and they were in vitro evaluated as antibacterial agents against six different types of microorganisms by using well diffusion method. All the tested N-acyl hydrazones (4a-g) displayed moderate activity against the Gram-negative E.coli, comparable to that of Amoxi

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25

Kodonidi, I. P., A. S. Chiriapkin, and D. E. Tworowski. "MOLECULAR DESIGN OF N-ACYL DERIVATIVES OF 2-(2-OXOPYROLIDIN-1-YL)-ACETAMIDE WITH GABA-ERGIC AND GLUTAMATERGIC ACTIVITIES." Pharmacy & Pharmacology 9, no. 1 (2021): 84–97. http://dx.doi.org/10.19163/2307-9266-2021-9-1-84-97.

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The first of the most successfully implemented nootropic drugs in medical practice is piracetam, which should be attributed to cyclic derivatives of gamma-aminobutyric acid. The production of new piracetam derivatives with high nootropic activity is a promising direction in the development of new neuroprotective drugs.The aim of the study is to predict GABA-ergic and glutamatergic activities of N-acyl derivatives of 2-(2-oxopyrolidin-1-yl)- acetamide by a molecular docking method through the energy analysis of interaction of modeled structures with GABAA and AMPA receptors with their subsequen

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26

Sejbal, Jan, Jiří Klinot, and Miloš Buděšínský. "Photolyses and pyrolyses of triterpenoid nitrites." Collection of Czechoslovak Chemical Communications 56, no. 8 (1991): 1732–43. http://dx.doi.org/10.1135/cccc19911732.

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Derivatives of 19β,28-epoxy-18α-oleanane and lupane with nitrosyloxy group in positions 1α, 2β, 3α, 3β and 28 (II, V, VIII, X and XXVII, respectively) were subjected to photolysis in solution and in the crystalline state, as well as to pyrolysis. In most cases the products identified were alcohols, ketones, olefins and seco derivatives. Photolysis of 2β-nitrile V in benzene afforded the known 24- and 25-oximino derivatives XV and XVII, photolysis of 1α-nitrite II in the crystalline state led to the little stable form XIX of N-hydroxylactam XXI which in solution was easily converted into the de

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27

Lissel, Manfred, and Achim Gau. "Reaktionen mit Kaliumsuperoxid 2 [1]. Spaltung von N-Acyl-glycinderivaten / Reactions with Potassium Superoxide 2 [1]. Cleavage of N-Acyl-glycine Derivatives." Zeitschrift für Naturforschung B 41, no. 3 (1986): 367–70. http://dx.doi.org/10.1515/znb-1986-0313.

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28

Kolasa, T. "Synthetic study on N-hydroxyaspartic acid." Canadian Journal of Chemistry 63, no. 8 (1985): 2139–42. http://dx.doi.org/10.1139/v85-352.

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29

Apostol, Theodora-Venera, Mariana Carmen Chifiriuc, George Mihai Nitulescu, et al. "In Silico and In Vitro Assessment of Antimicrobial and Antibiofilm Activity of Some 1,3-Oxazole-Based Compounds and Their Isosteric Analogues." Applied Sciences 12, no. 11 (2022): 5571. http://dx.doi.org/10.3390/app12115571.

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In this paper, we report on the antimicrobial activity assessment of 49 compounds previously synthesized as derivatives of alanine or phenylalanine that incorporate a 4-(4-X-phenylsulfonyl)phenyl fragment (X = H, Cl, or Br), namely 21 acyclic compounds (6 × N-acyl-α-amino acids, 1 × N-acyl-α-amino acid ester, and 14 × N-acyl-α-amino ketones) and 28 pentatomic heterocycles from the oxazole-based compound class (6 × 4H-1,3-oxazol-5-ones, 16 × 5-aryl-1,3-oxazoles, and 6 × ethyl 1,3-oxazol-5-yl carbonates). Both in silico and in vitro qualitative and quantitative assays were used to investigate th

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30

Kaválek, Jaromír, Josef Jirman, Vladimír Macháček, and Vojeslav Štěrba. "An anomalous effect of methyl group on acidity of acylthioureas." Collection of Czechoslovak Chemical Communications 52, no. 8 (1987): 1992–98. http://dx.doi.org/10.1135/cccc19871992.

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Dissociation constants and methanolysis rate constants have been measured of 1-acetyl- and 1-benzoylthioureas and their N-methyl derivatives. Replacement of hydrogen atom at N(1) (next to the acyl group) by methyl group increases the acidity of the benzoyl derivative by one order, that of the acetyl derivative by as much as two orders of magnitude. Replacement of both hydrogens at N(3) by methyl groups lowers the methanolysis rate constant by more than two orders, whereas the replacement of hydrogen atom at N(1) by methyl group increases the methanolysis rate by the factor of 30.

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31

Salkeeva, L. K., A. A. Muratbekova, E. V. Minayeva, et al. "Phosphorylation of glycoluryl derivatives with phosphorus pentachloride." Bulletin of the Karaganda University. "Chemistry" series 101, no. 1 (2021): 12–18. http://dx.doi.org/10.31489/2021ch1/12-18.

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The paperpresents the research results on the synthesis and study of new organophosphorus derivatives of glycoluril, obtained on the basis of pentavalent phosphorus. New organoelement phosphorus derivatives synthesized on the basis of N-acyl-substituted glycolurilhave been obtained.They are of considerable interest due to the presence of effective reaction centers. Tetraacetyl-substituted glycoluril —2,4,6,8-tetraacetyl-2,4,6,8-tetraazabicyclo[3,3,0]octane-3,7-dione was chosen as theinitial synthon. Theuse of unsubstituted glycoluril in the reaction of direct phosphorylation by the action of p

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32

SHISHKIN, E. V., O. V. ANISHCHENKO, M. A. SHEVCHENKO, and A. V. CHERIKOV. "STEPWISE SYNTHESIS OF ACYLATED N-PHOSPHORYLATED MALONODIIMIDATES." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 5(288) (May 2024): 45–48. http://dx.doi.org/10.35211/1990-5297-2024-5-288-45-48.

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A stepwise synthesis of acylated N-phosphorylated malonodiimidates is proposed. N-phosphorylated malonic acid imidates were used as starting compounds. At the first stage of synthesis, sodium derivatives of N-phosphorylated imidates were obtained, at the second stage, the corresponding acylated compounds were obtained by interaction of sodium derivatives with acyl chloride. For acylated derivatives of N-phosphorylated malonic acid imidates, inhibition of acetylesterase, esterase hydrolase, kutinase, and other enzymes is predicted with high probability.

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33

Zhang, Min, and Shigehiro Hirano. "Novel N-unsaturated fatty acyl and N-trimethylacetyl derivatives of chitosan." Carbohydrate Polymers 26, no. 3 (1995): 205–9. http://dx.doi.org/10.1016/0144-8617(95)00012-v.

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34

Paquet, A., and K. Rayman. "Some N-acyl-D-amino acid derivatives having antibotulinal properties." Canadian Journal of Microbiology 33, no. 7 (1987): 577–82. http://dx.doi.org/10.1139/m87-100.

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Several N-acyl derivatives of D-tryptophan, D-alanine, D-methionine, D-valine, and D-aspartic acid were synthesized in high yields using the succinimidyl ester method and examined for their antibotulinal properties. In conjunction with 60 ppm of sodium nitrite, sorbyl-D-tryptophan, sorbyl-D-alanine, myristoyl-D-aspartic acid, and glycyl-D-alanine were highly inhibitory. In the absence of sodium nitrite, the N-acyl derivatives of the D-amino acids were not inhibitory. On its own, 60 ppm of sodium nitrite was only slightly inhibitory. Sorbyl-L-tryptophan and sorbyl-L-alanine had no effect in the

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35

Chiriapkin, A. S., A. A. Glushko, and I. P. Kodonidi. "STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD." Juvenis Scientia, no. 3 (2019): 4–6. http://dx.doi.org/10.32415/jscientia.2019.03.01.

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The search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding site of NMDA receptor to search of new effective nootropic drugs. As objects of study, there are used the new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide, racetams, glutamate and a virtual model of NMDA receptor of organism Rattus norvegicus w

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36

ZOSIMO-LANDOLFO, G., J. M. J. TRONCHET, and F. HABASHI. "ChemInform Abstract: Hydroxyaminosugar Derivatives. Part 2. N- and O-Acyl Derivatives of Deoxy-N-hydroxyaminosugars." ChemInform 25, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199432213.

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37

Bertucci, Michael A., Stephen J. Lee, and Michel R. Gagné. "Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives." Org. Biomol. Chem. 12, no. 37 (2014): 7197–200. http://dx.doi.org/10.1039/c4ob01156b.

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38

Kim, Youngjae, Miyoung Yeom, Jinsung Tae, Hyewhon Rhim, and Hyunah Choo. "Novel N-acyl-carbazole derivatives as 5-HT7R antagonists." European Journal of Medicinal Chemistry 110 (March 2016): 302–10. http://dx.doi.org/10.1016/j.ejmech.2016.01.043.

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39

Barho, Marlene T., Sina Oppermann, Florian C. Schrader, et al. "N-Acyl Derivatives of 4-Phenoxyaniline as Neuroprotective Agents." ChemMedChem 9, no. 10 (2014): 2260–73. http://dx.doi.org/10.1002/cmdc.201402195.

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40

Du, Tianri, Xiangmu Wei, Honghong Xu, et al. "Chemoselective N-acylation of indoles using thioesters as acyl source." Beilstein Journal of Organic Chemistry 18 (January 10, 2022): 89–94. http://dx.doi.org/10.3762/bjoc.18.9.

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The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A series of indoleamides have been obtained with moderate to good yields. In addition, heterocycles, such as carbazole, can also be used as nucleophiles in this reaction.

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41

Zabaleta, Nagore, Uxue Uria, Efraim Reyes, Luisa Carrillo, and Jose L. Vicario. "Ion-pairing catalysis in the enantioselective addition of hydrazones to N-acyldihydropyrrole derivatives." Chemical Communications 54, no. 64 (2018): 8905–8. http://dx.doi.org/10.1039/c8cc05311a.

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42

Battista, Natalia, Monica Bari, and Tiziana Bisogno. "N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes." Biomolecules 9, no. 12 (2019): 822. http://dx.doi.org/10.3390/biom9120822.

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The lipid signal is becoming increasingly crowded as increasingly fatty acid amide derivatives are being identified and considered relevant therapeutic targets. The identification of N-arachidonoyl-ethanolamine as endogenous ligand of cannabinoid type-1 and type-2 receptors as well as the development of different–omics technologies have the merit to have led to the discovery of a huge number of naturally occurring N-acyl-amines. Among those mediators, N-acyl amino acids, chemically related to the endocannabinoids and belonging to the complex lipid signaling system now known as endocannabinoido

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43

Shi, Ting-Ting, Zheng Fang, Wen-Bo Zeng, Zhao Yang, Wei He та Kai Guo. "Design, synthesis and properties investigation of Nα-acylation lysine based derivatives". RSC Advances 9, № 13 (2019): 7587–93. http://dx.doi.org/10.1039/c9ra00213h.

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Chen, Pu, Huawen Huang, Qi Tan, Xiaochen Ji, and Feng Zhao. "Recent Advances in Molecule Synthesis Involving C-C Bond Cleavage of Ketoxime Esters." Molecules 28, no. 6 (2023): 2667. http://dx.doi.org/10.3390/molecules28062667.

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The synthetic strategies of oxime derivatives participating in radical-type reactions have been rapidly developed in the last few decades. Among them, the N–O bond cleavage of oxime esters leading to formation of nitrogen-centered radicals triggers adjacent C–C bond cleavage to produce carbon-centered free radicals, which has been virtually used in organic synthesis in recent years. Herein, we summarized the radical reactions involving oxime N–O bond and C–C bond cleavage through this special reaction form, including those from acyl oxime ester derivatives and cyclic ketoxime ester derivatives

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Cablewski, Teresa, Craig M. Forsyth, Craig L. Francis, Andris J. Liepa, and Victor Tran. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part VII 4-Dialkylamino[1,2,3,5]Benzoxathiadiazepine Dioxides and 4-Dialkylamino-[2,1,3,5]Benzothiatriazepine Dioxides." Australian Journal of Chemistry 61, no. 10 (2008): 785. http://dx.doi.org/10.1071/ch08250.

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N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 reacted with 2-aminophenols 2 to give 4-dialkylamino[1,2,3,5]benzoxathiadiazepine dioxides 3, which are examples of a new ring system. Reaction of 1 with 1,2-diaminobenzenes 7 afforded 4-dialkylamino[2,1,3,5]benzothiatriazepine dioxides 8 and 9, which are new derivatives of a rare ring system. Some N-alkyl and N-acyl derivatives of 3 and 8 were prepared to demonstrate the potential of these compounds as novel scaffolds for synthetic and medicinal chemistry.

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Nilesh, S. Pawar, and M. Zalte Sanjay. "STUDIES AN ANTIMICROBIAL ACTIVITY OF VARIOUS N-SUBSTITUTED PHTHALIMIDES DERIVATIVES." Biolife 2, no. 4 (2022): 1027–33. https://doi.org/10.5281/zenodo.7228920.

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<strong>ABSTRACT</strong> Structural modification of various <em>N</em>-substituted phthalimides compounds through such simple, rapid and environment-friendly approach polymer support method has been taken to study the bioassay and their structure-activity relationships (SAR). Derivatization of phthalimide and <em>N</em>-hydroxy phthalimide exhibits good antibacterial efficacy and very less antifungal potency even though parent phthalimide moiety oriented compounds are potent fungicides. <strong>Key words:</strong> <em>N</em>-alkyl, <em>N</em>-acyl, <em>N</em>-alkyloxy, <em>N</em>-acyloxy, pht

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Cruz, Alejandro, Itzia I. Padilla-Martínez, and Maria E. Bautista-Ramirez. "Ephedrines as Chiral Auxiliaries in Enantioselective Alkylation Reactions of Acyl Ephedrine Amides and Esters: A Review." Current Organic Synthesis 15, no. 1 (2018): 38–83. http://dx.doi.org/10.2174/1570179414666170830125915.

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Background: In modern chemistry, the asymmetric synthesis for the preparation of high purity chiral compounds to be used as pharmaceuticals or additives in foods have been of capital importance. Chiral auxiliary reagents are used to control the stereochemistry of the reaction in the generation of new chiral compounds, in this context, Ephedra compounds (ephedrines and pseudoephedrines) and some of their derivatives have been broadly used as chiral ligands in catalysis or chiral inductors in asymmetric synthesis. Objective: This review focuses on recent progress in the use of ephedra compounds

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Plattner, Jake J., Daniel Chu, Elena P. Mirchink та ін. "N′-(α-Aminoacyl)- and N′-α-(N-Alkylamino)acyl Derivatives of Vancomycin and Eremomycin". Journal of Antibiotics 60, № 4 (2007): 245–50. http://dx.doi.org/10.1038/ja.2007.29.

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Slobodianiuk, Oksana, Oleksandra Berezhnytska, Tetyana Kamens'ka, and Мария Русакова. "SYNTHESIS AND PROPERTIES OF NEW N-ACYL DERIVATIVES OF ANTHRANILIC ACID." Ukrainian Chemistry Journal 85, no. 4 (2019): 59–70. http://dx.doi.org/10.33609/0041-6045.85.4.2019.59-70.

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A series of N-acyl derivatives of anthranil (or o -aminobenzoic acid) was first synthesized, namely 2-(4-octylbenzamido)benzoic acid, 2-(4-(heptyloxy)- benzamido)benzoic acid, 2-(4-(heptylsulfanyl)benz-amido)benzoic acid. 2-(4-octylbenzamido)benzoic acid was synthesized in five stages of octylbenzene, by acylating chloride acid using a Friedie-Crafts reaction. 2-(4-(heptyloxy)benzamido)benzoic acid was prepared from the methyl ester of p-hydroxybenzoic acid which, at the first stage, was activated with 1-bromoheptane in acetonitrile with potassium carbonate and catalytic amount of sodium iodid

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Kodonidi, I. P., D. S. Anenko та D. I. Pozdnyakov. "Synthesis and Action of N-acylphenylacetamides and N-acyl-β-ketoamides on the Central Nervous System". Drug development & registration 11, № 1 (2022): 40–49. http://dx.doi.org/10.33380/2305-2066-2022-11-1-40-49.

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Introduction. One of the most promising directions in the search for biologically active compounds is the molecular design of biologically active compounds containing a known pharmacoform fragment. In this article, phenylacetic acid derivatives are considered as a scaffold for the search for biologically active compounds. However, the phenylacetamide derivative is of particular interest, its fragment is included in the structure of the atenolol drug. Optimization of methods for the synthesis of N-acylphenylacetamides and N-acyl-β-ketoamides will expand the boundaries of molecular design and ta

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