Academic literature on the topic 'N-acylethanolamine (Anandamide)'

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Journal articles on the topic "N-acylethanolamine (Anandamide)"

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Fonseca, B. M., G. Correia-da-Silva, A. H. Taylor, et al. "N-Acylethanolamine Levels and Expression of Their Metabolizing Enzymes during Pregnancy." Endocrinology 151, no. 8 (2010): 3965–74. http://dx.doi.org/10.1210/en.2009-1424.

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Decidualization is essential for a successful pregnancy and is a tightly regulated process influenced by the local microenvironment. Lipid-based mediators, such as the endocannabinoid anandamide, and other compounds that have cannabimimetic actions may act on the decidua during early pregnancy. In this study, the levels of N-arachidonoylethanolamine (anandamide) and two other N-acylethanolamines, N-oleoylethanolamine and N-palmitoylethanolamine, were measured in rat plasma and maternal tissues between d 8 and 19 of pregnancy by ultraperformance liquid chromatography tandem mass spectrometry. T
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BERDYSHEV, Evgueni V., Patricia C. SCHMID, Zigang DONG, and Harald H. O. SCHMID. "Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells." Biochemical Journal 346, no. 2 (2000): 369–74. http://dx.doi.org/10.1042/bj3460369.

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It has long been known that N-acylethanolamine phospholipids [N-acylphosphatidylethanolamine (N-acyl PE)] and N-acylethanolamines (NAEs) accumulate in mammalian tissues undergoing degenerative membrane changes associated with necrosis. Here we studied the effects of stress factors (UVB irradiation and serum deprivation) on the endogenous levels of N-acyl PE and NAE in mouse epidermal JB6 P+ cells. We found that 16:0, 18:0, 18:1,n-9 and 18:1,n-7 are the predominant amide-linked fatty acids in both N-acyl PE and NAE in these cells. UVB irradiation and serum deprivation resulted in significantly
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Guo, Yiman, Toru Uyama, S. M. Khaledur Rahman та ін. "Involvement of the γ Isoform of cPLA2 in the Biosynthesis of Bioactive N-Acylethanolamines". Molecules 26, № 17 (2021): 5213. http://dx.doi.org/10.3390/molecules26175213.

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Arachidonylethanolamide (anandamide) acts as an endogenous ligand of cannabinoid receptors, while other N-acylethanolamines (NAEs), such as palmitylethanolamide and oleylethanolamide, show analgesic, anti-inflammatory, and appetite-suppressing effects through other receptors. In mammalian tissues, NAEs, including anandamide, are produced from glycerophospholipid via N-acyl-phosphatidylethanolamine (NAPE). The ɛ isoform of cytosolic phospholipase A2 (cPLA2) functions as an N-acyltransferase to form NAPE. Since the cPLA2 family consists of six isoforms (α, β, γ, δ, ɛ, and ζ), the present study i
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Sun, Yong-Xin, Kazuhito Tsuboi, Li-Ying Zhao, Yasuo Okamoto, Didier M. Lambert, and Natsuo Ueda. "Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1736, no. 3 (2005): 211–20. http://dx.doi.org/10.1016/j.bbalip.2005.08.010.

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Schmid, Harald H. O. "Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively?" Chemistry and Physics of Lipids 108, no. 1-2 (2000): 71–87. http://dx.doi.org/10.1016/s0009-3084(00)00188-2.

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Pai, Alex Y., Cachet Wenziger, Elani Streja, et al. "Impact of Circulating N-Acylethanolamine Levels with Clinical and Laboratory End Points in Hemodialysis Patients." American Journal of Nephrology 52, no. 1 (2021): 59–68. http://dx.doi.org/10.1159/000513381.

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Background: Patients with ESRD on maintenance hemodialysis (MHD) are particularly susceptible to dysregulation of energy metabolism, which may manifest as protein energy wasting and cachexia. In recent years, the endocannabinoid system has been shown to play an important role in energy metabolism with potential relevance in ESRD. N-acylethanolamines are a class of fatty acid amides which include the major endocannabinoid ligand, anandamide, and the endogenous peroxisome proliferator-activated receptor-α agonists, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). Methods: Serum concentr
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Hansen, Henrik H., Chrysanthy Ikonomidou, Petra Bittigau, Steen Honoré Hansen, and Harald S. Hansen. "Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death." Journal of Neurochemistry 76, no. 1 (2008): 39–46. http://dx.doi.org/10.1046/j.1471-4159.2001.00006.x.

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Hansen, Henrik H., Steen Honoré Hansen, Arne Schousboe, and Harald S. Hansen. "Determination of the Phospholipid Precursor of Anandamide and Other N-Acylethanolamine Phospholipids Before and After Sodium Azide-Induced Toxicity in Cultured Neocortical Neurons." Journal of Neurochemistry 75, no. 2 (2002): 861–71. http://dx.doi.org/10.1046/j.1471-4159.2000.0750861.x.

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Hansen, Harald S., and Thi Ai Diep. "N-acylethanolamines, anandamide and food intake." Biochemical Pharmacology 78, no. 6 (2009): 553–60. http://dx.doi.org/10.1016/j.bcp.2009.04.024.

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BERDYSHEV, Evgueni V., Patricia C. SCHMID, Randy J. KREBSBACH, et al. "Cannabinoid-receptor-independent cell signalling by N-acylethanolamines." Biochemical Journal 360, no. 1 (2001): 67–75. http://dx.doi.org/10.1042/bj3600067.

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Anandamide and other polyunsaturated N-acylethanolamines (NAEs) exert biological activity by binding to cannabinoid receptors. These receptors are linked to Gi/o proteins and their activation leads to extracellular-signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAP kinase) activation, inhibition of cAMP-dependent signalling and complex changes in the expression of various genes. Saturated and monounsaturated NAEs cannot bind to cannabinoid receptors and may thus mediate cell signalling through other targets. Here we report that both sa
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Dissertations / Theses on the topic "N-acylethanolamine (Anandamide)"

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Haq, Imdadul, Suhas Shinde, and Aruna Kilaru. "Elucidating the Role of N-Acylethanolamine/Anandamide Metabolism in the Moss Physcomitrella Patens." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/4827.

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In plants, saturated and unsaturated N-Acylethanolamines (NAEs) with acyl chains 12C to 18C are reported for their differential levels in various tissues and species. While NAEs were shown to play a vital role in mammalian neurological and physiological functions, its metabolism and functional implications in plants however, remains incomplete. Recently, anandamide (NAE 20:4), an essential fatty acid neurotransmitter in mammalian system, was identified in moss Physcomitrella patens, in addition to other types of NAEs. Bryophytes display high tolerance to abiotic stress and thus presence of ana
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Swati, Swati. "Cloning of N-acylethanolamine Metabolic Pathway Genes from Physcomitrella patens." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3178.

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N-acylethanolamines (NAEs) including anandamide are lipid derivative molecules, which play vital roles in physiological and developmental processes in plants and animals and mediate stress responses. In mammals, NAEs are synthesized from hydrolysis of their precursor molecule N-acylphosphatidylethanolamine (NAPE) by NAPE-specific phospholipaseD (NAPE-PLD). All NAEs including anandamide (NAE20:4) are hydrolyzed by fatty acid amide hydrolase (FAAH) into free fatty acid and ethanolamine. To date, different NAEs including anandamide have been identified in Physcomitrella patens but its metabolic p
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Chilufya, Jedaidah Y. "Anandamide-Mediated Growth Changes in Physcomitrella patens." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3162.

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Anandamide (NAE 20:4) or arachidonlyethanolamine (AEA) is the most widely studied N-acylethanolamine (NAE) because it mediates several physiological functions in mammals. In vascular plants, 12-18C NAEs inhibit growth in an abscisic acid (ABA)-dependent and -independent manner. Anandamide, which is unique to bryophyte Physcomitrella patens, inhibited gametophyte growth and reduced chlorophyll content when applied exogenously. It is hypothesized that anandamide mediates its responses through morphological and cellular changes. Following growth inhibition by short-term anandamide-treatment, micr
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Dey, Rafik. "Étude comparée de la prolifération de Legionella pneumophila dans différents hôtes amibiens et de leurs inter - relations : implication potentielle de phospholipides aminés." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00650228.

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Il est aujourd'hui bien établi que les amibes libres jouent le rôle de vecteurs à la bactérie pathogène Legionella pneumophila favorisant ainsi son développement et sa propagation dans l'environnement. Ainsi, et jusqu'à maintenant, toutes les espèces d'amibes libres étudiées ont démontré une capacité à soutenir et favoriser la croissance de la bactérie responsable des légionelloses. Toutefois, l'ensemble des études a porté sur un nombre restreint d'espèces amibiennes, et leurs capacités relatives à soutenir la croissance bactérienne n'ont que très peu été abordées. Nous avons comparé la capaci
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Chilufya, Jedaidah Y., Shivakumar P. Devaiah, Richard R. Sante, and Aruna Kilaru. "Endocannabinoid-Like Lipids in Plants." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/4747.

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Classically, endogenous fatty acid ethanolamides and their derivatives that bind to the cannabinoid receptors and trigger a signalling pathway are referred to as endocannabinoids. Although derivatives of arachidonic acid, including arachidonylethanolamine or anandamide, are the known endogenous ligands for cannabinoid receptors, other fatty acid ethanolamides or N-acylethanolamines (NAE) that vary in carbon chain length and saturation occur ubiquitously in eukaryotic organisms and play an important role in their physiology and development. The metabolic pathway for NAEs is highly conserved amo
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Shinde, Suhas, Ruth Welti, and Aruna Kilaru. "NOVEL POLYUNSATURATED N-ACYLETHANOLAMINES AND THEIR IMPLICATIONS IN PHYSCOMITRELLA PATENS." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/111.

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N-Acylethanolamines (NAEs), although are ubiquitous in plants and animals the occurrence of endocannabinoid ligands and the corresponding cannabinoid receptors was limited to mammals. Interestingly, bryophytes, unlike seed plants possess arachidonic acid (AA, 20:4) and eicosapentaenoic acid (EPA, 20:5), which are fatty acid precursors for endocannabinoid ligands. Here, we show that the moss Physcomitrella patens contains ~24 and 7 % of AA and EPA, respectively. Using selective lipidomic profiling, we identified polyunsaturated NAEs, including N-arachidonoyl ethanolamide (anandamide/AEA/NAE 20:
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Almaedani, Abdalla. "Omega-3 polyunsaturated fatty acids and their impact upon the biosynthesis of endocannabinoids and N-acylethanolamines in human skin cells in the presence and absence of ultraviolet radiation." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/omega3-polyunsaturated-fatty-acids-and-their-impact-upon-the-biosynthesis-of-endocannabinoids-and-nacylethanolamines-in-human-skin-cells-in-the-presence-and-absence-of-ultraviolet-radiation(98694ccf-d7c4-4d5b-81fa-0691e06e5a4b).html.

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Endocannabinoids are endogenous lipid mediators involved in various biological processes, and have immunomodulatory and anti-inflammatory activities. Anandamide (arachidonoyl ethanolamine, AEA) and 2-arachidonoyl glycerol (2-AG) are the main representatives of this group. The endocannabinoid receptors CB1 and CB2 with AEA have been found in human HaCaT keratinocytes and fibroblasts, but the metabolic pathway leading to endocannabinoid production in the skin has not been fully elucidated. This study aimed to investigate the profile of endocannabinoids and their main metabolizing enzymes in huma
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Book chapters on the topic "N-acylethanolamine (Anandamide)"

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Hansen, H. S., B. Moesgaard, H. H. Hansen, and G. Petersen. "When and Where Are N-Acylethanolamine Phospholipids and Anandamide Formed?" In Fatty Acids and Lipids - New Findings. KARGER, 2000. http://dx.doi.org/10.1159/000059758.

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Ueda, N., K. Yamanaka, K. Katayama, S. K. Goparaju, H. Suzuki, and S. Yamamoto. "Alkaline and Acid Amidases Hydrolyzing Anandamide and Other N-Acylethanolamines." In Fatty Acids and Lipids - New Findings. KARGER, 2000. http://dx.doi.org/10.1159/000059754.

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