Relevant bibliographies by topics / N-aryl piperazines

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'N-aryl piperazines'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "N-aryl piperazines"

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Mishra, Vaibhav, Anju Arya, and Tejpal Singh Chundawat. "High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines." Current Organocatalysis 7, no. 1 (2019): 23–33. http://dx.doi.org/10.2174/2213337206666190515091945.

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Background: The N-aryl piperazines are an important component of many drug products used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig amination is the latest and well-known reaction for Pd catalyzed direct synthesis of N-aryl piperazine from aryl halides. Although several Pd-ligand systems have already been discovered for this conversion, Pd nanoparticles are recently being used for this useful coupling reaction due to their recyclability and durability. Metal nanoparticles show enhanced catalytic activity compared to their bulk counterparts due to
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Hafeez, Freeha, Ameer Fawad Zahoor, Azhar Rasul, et al. "Ultrasound-Assisted Synthesis and In Silico Modeling of Methanesulfonyl-Piperazine-Based Dithiocarbamates as Potential Anticancer, Thrombolytic, and Hemolytic Structural Motifs." Molecules 27, no. 15 (2022): 4776. http://dx.doi.org/10.3390/molecules27154776.

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Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological activities. Under ultrasound conditions, the corresponding piperazine-1-carbodithioates 5a–5j were synthesized from monosubstituted piperazine 2 and N-phenylacetamides 4a–4j in the presence of sodium acetate and carbon disulfide in methanol. The structures of the newly synthesized piperazines were confirmed, and their anti-lung carcinoma effects were
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Liu, Kevin G., and Albert J. Robichaud. "A general and convenient synthesis of N-aryl piperazines." Tetrahedron Letters 46, no. 46 (2005): 7921–22. http://dx.doi.org/10.1016/j.tetlet.2005.09.092.

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Yavari, Issa, Mohammad J. Bayat, and Majid Ghazanfarpour-Darjani. "Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C–N bond formation." Tetrahedron Letters 55, no. 41 (2014): 5595–96. http://dx.doi.org/10.1016/j.tetlet.2014.08.045.

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Michalik, Dirk, Kamal Kumar, Alexander Zapf, et al. "A short and efficient synthesis of N-aryl- and N-heteroaryl-N′-(arylalkyl)piperazines." Tetrahedron Letters 45, no. 10 (2004): 2057–61. http://dx.doi.org/10.1016/j.tetlet.2004.01.066.

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Glowka, Marek, Malgorzata Szczesio, and Andrzej Olczak. "Crystallographic approach to determination of active conformations of LCAPs." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1697. http://dx.doi.org/10.1107/s2053273314083028.

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Long-Chain Aryl-Piperazines (LCAPs) are well known serotonin receptor ligands used in several marketed antidepressant drugs. LCAPs consist of three structural units: a terminal group, an arylpiperazine at one N atom and an aliphatic chain (spacer) at the other N atom joining the two former units. Both the arylpiperazine and the terminal groups have rather rigid structures and thus their conformational freedom is limited. The opposite is true for the aliphatic spacer, which allows practically any orientation of the terminal group. The resulting diversity of conformations observed in the crystal
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Yavari, Issa, Mohammad J. Bayat, and Majid Ghazanfarpour-Darjani. "ChemInform Abstract: Synthesis of N-Alkyl-N′-aryl-piperazines via Copper-Catalyzed C-N Bond Formation." ChemInform 46, no. 11 (2015): no. http://dx.doi.org/10.1002/chin.201511245.

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Fan, Chenguang, and Keith Vaughan. "Synthesis and Characterization of a Series of 1-Aryl-4-[aryldiazenyl]- piperazines. Part I. Isomers of N-(2,3-Dimethylphenyl)-N’-(Aryldiazenyl)- Piperazines." Open Chemistry Journal 2, no. 1 (2015): 20–35. http://dx.doi.org/10.2174/1874842201502010020.

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This paper describes the synthesis of several new series of 1-(2-aryldiazen-1-yl-) 4-arylpiperazines and 1-(2- aryldiazen-1-yl-)4-arylalkylpiperazines by using diazonium coupling between arenediazonium ions with the appropriate 1-arylpiperazine or the 1-arylalkylpiperazine. The new compounds have a common thread in that they are isomers of the series of N-(2,3-dimethylphenyl)- N’-(aryldiazenyl)-piperazines. The new triazenes have been characterized by IR and NMR spectroscopy and mass spectrometry.
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Silvio Caccia. "N-Dealkylation of Arylpiperazine Derivatives: Disposition and Metabolism of the 1-Aryl-Piperazines Formed." Current Drug Metabolism 8, no. 6 (2007): 612–22. http://dx.doi.org/10.2174/138920007781368908.

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Zhou, Ya, Jason T. Manka, Alice L. Rodriguez, et al. "Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility." ACS Medicinal Chemistry Letters 1, no. 8 (2010): 433–38. http://dx.doi.org/10.1021/ml100181a.

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Dissertations / Theses on the topic "N-aryl piperazines"

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Zajdel, Pawel. "Novel Aryl-alkyl-piperazines with N-acylated amino acids as serotoninergic receptors ligands." Montpellier 1, 2006. http://www.theses.fr/2006MON13511.

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Ce travail présente des nouveaux composés ciblant les récepteurs sérotoninergiques. La première partie traite de la synthèse supposée d'une chimiothèque d'arylpiperazines. Plusieurs composés montrent une haute affinité pour 5-HT1A(K1=3-52nM). Des tests pharmacologiques pré-cliniques ont révélé des comportements de type agoniste complet ou partiel de 5-HT1A ou antagoniste 5-HT1A/5-HT2A. La synthèse supportée de 64 dérivés sulfonamide de la proline carboxamide est décrite, visant l'obtention d'antagonistes de 5-HT7. La dernière partie traite de la synthèse supportée sur lanternes BAL de dérivés
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Conference papers on the topic "N-aryl piperazines"

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Andrić, Deana B., Slađana Dukić-Stefanovic, Jelena Z. Penjišević, et al. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL N- {4-[2-(4-ARYL-PIPERAZIN-1-YL)-ETHYL]-PHENYL}-ARYLAMIDES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.355a.

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5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disorders, such as schizophrenia and depression. As a part of ongoing research, we designed series of new compounds that share arylpiperazine common structural motif with the 5HT1A receptor ligand aripiprazole. Receptor-ligand interactions were determined by the molecular docking simulations, revealing the positive impact of the phenyl substitution in the arylpiperazine part of the molecules. Nine selected compounds were synthesized in four reaction steps in high overall yields (59-73%). In vitro pharm
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Recabarren-Gajardo, G., C. Espinosa-Bustos, D. Hebel, et al. "Design and Synthesis of 3-[1-oxo-(4-aryl-1-piperazinyl)alkyl]-N- (arylsulfonyl)-indoles as Potential Antagonists Agents on 5- HT6 Receptors." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0169-2.

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Journal articles
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