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Journal articles on the topic 'N-aryl piperazines'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Mishra, Vaibhav, Anju Arya, and Tejpal Singh Chundawat. "High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines." Current Organocatalysis 7, no. 1 (2019): 23–33. http://dx.doi.org/10.2174/2213337206666190515091945.

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Background: The N-aryl piperazines are an important component of many drug products used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig amination is the latest and well-known reaction for Pd catalyzed direct synthesis of N-aryl piperazine from aryl halides. Although several Pd-ligand systems have already been discovered for this conversion, Pd nanoparticles are recently being used for this useful coupling reaction due to their recyclability and durability. Metal nanoparticles show enhanced catalytic activity compared to their bulk counterparts due to

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2

Hafeez, Freeha, Ameer Fawad Zahoor, Azhar Rasul, et al. "Ultrasound-Assisted Synthesis and In Silico Modeling of Methanesulfonyl-Piperazine-Based Dithiocarbamates as Potential Anticancer, Thrombolytic, and Hemolytic Structural Motifs." Molecules 27, no. 15 (2022): 4776. http://dx.doi.org/10.3390/molecules27154776.

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Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological activities. Under ultrasound conditions, the corresponding piperazine-1-carbodithioates 5a–5j were synthesized from monosubstituted piperazine 2 and N-phenylacetamides 4a–4j in the presence of sodium acetate and carbon disulfide in methanol. The structures of the newly synthesized piperazines were confirmed, and their anti-lung carcinoma effects were

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3

Liu, Kevin G., and Albert J. Robichaud. "A general and convenient synthesis of N-aryl piperazines." Tetrahedron Letters 46, no. 46 (2005): 7921–22. http://dx.doi.org/10.1016/j.tetlet.2005.09.092.

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4

Yavari, Issa, Mohammad J. Bayat, and Majid Ghazanfarpour-Darjani. "Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C–N bond formation." Tetrahedron Letters 55, no. 41 (2014): 5595–96. http://dx.doi.org/10.1016/j.tetlet.2014.08.045.

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5

Michalik, Dirk, Kamal Kumar, Alexander Zapf, et al. "A short and efficient synthesis of N-aryl- and N-heteroaryl-N′-(arylalkyl)piperazines." Tetrahedron Letters 45, no. 10 (2004): 2057–61. http://dx.doi.org/10.1016/j.tetlet.2004.01.066.

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6

Glowka, Marek, Malgorzata Szczesio, and Andrzej Olczak. "Crystallographic approach to determination of active conformations of LCAPs." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1697. http://dx.doi.org/10.1107/s2053273314083028.

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Long-Chain Aryl-Piperazines (LCAPs) are well known serotonin receptor ligands used in several marketed antidepressant drugs. LCAPs consist of three structural units: a terminal group, an arylpiperazine at one N atom and an aliphatic chain (spacer) at the other N atom joining the two former units. Both the arylpiperazine and the terminal groups have rather rigid structures and thus their conformational freedom is limited. The opposite is true for the aliphatic spacer, which allows practically any orientation of the terminal group. The resulting diversity of conformations observed in the crystal

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7

Yavari, Issa, Mohammad J. Bayat, and Majid Ghazanfarpour-Darjani. "ChemInform Abstract: Synthesis of N-Alkyl-N′-aryl-piperazines via Copper-Catalyzed C-N Bond Formation." ChemInform 46, no. 11 (2015): no. http://dx.doi.org/10.1002/chin.201511245.

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8

Fan, Chenguang, and Keith Vaughan. "Synthesis and Characterization of a Series of 1-Aryl-4-[aryldiazenyl]- piperazines. Part I. Isomers of N-(2,3-Dimethylphenyl)-N’-(Aryldiazenyl)- Piperazines." Open Chemistry Journal 2, no. 1 (2015): 20–35. http://dx.doi.org/10.2174/1874842201502010020.

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This paper describes the synthesis of several new series of 1-(2-aryldiazen-1-yl-) 4-arylpiperazines and 1-(2- aryldiazen-1-yl-)4-arylalkylpiperazines by using diazonium coupling between arenediazonium ions with the appropriate 1-arylpiperazine or the 1-arylalkylpiperazine. The new compounds have a common thread in that they are isomers of the series of N-(2,3-dimethylphenyl)- N’-(aryldiazenyl)-piperazines. The new triazenes have been characterized by IR and NMR spectroscopy and mass spectrometry.

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9

Silvio Caccia. "N-Dealkylation of Arylpiperazine Derivatives: Disposition and Metabolism of the 1-Aryl-Piperazines Formed." Current Drug Metabolism 8, no. 6 (2007): 612–22. http://dx.doi.org/10.2174/138920007781368908.

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10

Zhou, Ya, Jason T. Manka, Alice L. Rodriguez, et al. "Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility." ACS Medicinal Chemistry Letters 1, no. 8 (2010): 433–38. http://dx.doi.org/10.1021/ml100181a.

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11

Zaręba, Przemysław, Paweł Śliwa, Grzegorz Satała, Paweł Zajdel, Gniewomir Latacz, and Jolanta Jaśkowska. "New N-aryl-N′-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT1A receptor." European Journal of Medicinal Chemistry 235 (May 2022): 114319. http://dx.doi.org/10.1016/j.ejmech.2022.114319.

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12

Carter, David S., Hai-Ying Cai, Eun Kyung Lee, et al. "2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression." Bioorganic & Medicinal Chemistry Letters 20, no. 13 (2010): 3941–45. http://dx.doi.org/10.1016/j.bmcl.2010.05.008.

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13

SAXENA, A. K., J. RAO, R. C. SRIMAL, E. AUDRY, and A. CARPY. "ChemInform Abstract: Synthesis and QSAR Studies on Hypotensive N-(3-Aryl(thio/sulfono) propyl)piperazines/piperidines." ChemInform 25, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199418162.

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14

Jevtic, Ivana, Jelena Penjisevic, Milovan Ivanovic, and Sladjana Kostic-Rajacic. "Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores." Journal of the Serbian Chemical Society 84, no. 7 (2019): 639–47. http://dx.doi.org/10.2298/jsc181002105j.

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A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group chain were synthesized in 33, 35 and 39 % overall yield after a four-step synthetic route starting from three commercially available N-aryl piperazines. The anilino piperidine precursor was easily prepared in three steps, as previously published, starting from 4- piperidone. The synthesis presented in this paper could be of interest for hetero

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15

Bugaenko, Dmitry I., Marina A. Yurovskaya, and Alexander V. Karchava. "N-Arylation of DABCO with Diaryliodonium Salts: General Synthesis ofN-Aryl-DABCO Salts as Precursors for 1,4-Disubstituted Piperazines." Organic Letters 20, no. 20 (2018): 6389–93. http://dx.doi.org/10.1021/acs.orglett.8b02676.

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16

Hulinská, Hana, Zdeněk Polívka, Jiří Jílek, et al. "Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1820–44. http://dx.doi.org/10.1135/cccc19881820.

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Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)-dibenz[b,f]azepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V-XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I). Contributions to the syntheses and characterization of mianserin (XIX),

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17

Qasid, Muhammad, Ayaz Ahmad, and Talal Ahmed. "REVIEW ANALYSIS ON SYNTHESIS, ENZYME INHIBITION AND HEMOLYTIC STUDY OF NOVEL ACETAMIDE DERIVATIVES." Journal of Technology & Innovation 4, no. 1 (2024): 01–10. https://doi.org/10.26480/jtin.01.2024.01.10.

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The synthesis of 2- (2,4-dichloro-6-{[4-(2-furoyl)-1-piperazine]sulfonyl}phenoxy)-N-(aryl) acetamides was carried out under the controlled conditions as mentioned in the scheme. In the first step, the nucleophile is formed by reacting the calculated amount of N-(2-furoyl) piperazine (1) with 3,5-dichloro-2-hydroxybenzenesulfonylchloride (2) in the presence of an aqueous solution of sodium carbonate and stirred for three hours at room temperature to produce{4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2-furoyl)methanone (3). In the parallel set of reactions, electrophile was prepar

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18

Perrone, Roberto, Francesco Berardi, Nicola A. Colabufo, et al. "Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships." Journal of Medicinal Chemistry 37, no. 1 (1994): 99–104. http://dx.doi.org/10.1021/jm00027a012.

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19

PERRONE, R., F. BERARDI, N. A. COLABUFO, et al. "ChemInform Abstract: Mixed 5-HT1A/D-2 Activity of a New Model of Arylpiperazines: 1-Aryl-4-( 3-(1,2-dihydronaphthalen-4-yl)-n-propyl)piperazines. Part 1. Synthesis and Structure-Activity Relationships." ChemInform 25, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.199417184.

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20

Tsaplin, G. V., E. I. Bashkalova, A. L. Alekseenko, and S. V. Popkov. "Synthesis of azole derivatives of 1,2,3-dithiazole-5-imines and study of their fungicidal." Журнал общей химии 93, no. 12 (2023): 1846–53. http://dx.doi.org/10.31857/s0044460x23120041.

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A three-stage method was proposed for the synthesis of new 4-[4-(2-azolylethyl)piperazine-1-yl]- N -aryl-5 H 1,2,3-dithiazole-5-imines. This approach includes the reaction of Appel salt with anilines to produce 1,2,3-dithiazole-5-imines, which were converted into 4-[(4-chloroethyl)piperazine-1-yl]-5 H -1,2,3-dithiazole-5-imines, alkylating azoles at the final stage. The high fungicidal activity of target compounds and intermediate 4-chloro N -aryl-1,2,3-dithiazole-5-imines was shown in vitro tests versus six species of phytopathogenic fungi.

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21

Tsaplin, G. V., E. I. Bashkalova, A. L. Alekseenko, and S. V. Popkov. "Synthesis of Azole Derivatives of 1,2,3-Dithiazole-5-imines and Study of Their Fungicidal." Russian Journal of General Chemistry 93, no. 12 (2023): 3055–61. http://dx.doi.org/10.1134/s1070363223120046.

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Abstract A three-stage method was proposed for the synthesis of new 4-[4-(2-azolylethyl)piperazine-1-yl]-N-aryl-5H-1,2,3-dithiazole-5-imines. This approach includes the reaction of Appel salt with anilines to produce 1,2,3-dithiazole-5-imines, which were converted into 4-[(4-chloroethyl)piperazine-1-yl]-5H-1,2,3-dithiazole-5-imines, alkylating azoles at the final stage. The high fungicidal activity of target compounds and intermediate 4-chloro-N-aryl-1,2,3-dithiazole-5-imines was shown in vitro tests versus six species of phytopathogenic fungi.

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22

Al-Alshaikh, Monirah A., Aamal A. Al-Mutairi, Hazem A. Ghabbour, Ali A. El-Emam, Mohammed S. M. Abdelbaky, and Santiago Garcia-Granda. "Syntheses and crystal structures of two adamantyl-substituted 1,2,4-triazole-5-thione N-Mannich bases." Acta Crystallographica Section E Crystallographic Communications 73, no. 8 (2017): 1135–39. http://dx.doi.org/10.1107/s2056989017009756.

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In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-[(4-phenylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione (C29H34FN5S) (I), and 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-{[4-(2-methoxyphenyl)piperazin-1-yl]-methyl}-4,5-dihydro-1H-1,2,4-triazole-5-thione (C30H36FN5OS) (II), fluorophenyl, adamantane and piperazine moieties are linked to a planar triazole ring. There is an additional phenyl ring on the piperazine ring in (I) and a methoxyphenyl ring in (II). In compound (I), the fluorophenyl and phenyl rings are inclined to the triazole ring by 86.55 (13) and 60.

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23

Kwok, Chun-Kiu, and Thomas C. W. Mak. "Synthesis and structural characterization of N,N′-diarylpiperazine N,N′-dioxide tetrahydrates (aryl = o-tolyl, p-tolyl, p-chlorophenyl)." Canadian Journal of Chemistry 66, no. 8 (1988): 1836–47. http://dx.doi.org/10.1139/v88-297.

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The synthesis and X-ray structure determination of N,N′-di(o-tolyl)piperazine N,N′-dioxide tetrahydrate, I, N,N′-di(p-tolyl)piperazine N,N′-dioxide tetrahydrate, II, and N,N′-di(p-chlorophenyl)piperazine N,N′-dioxide tetrahydrate, III, are described. Compound I crystallizes in space group [Formula: see text] with a = 7.778(1), b = 7.915(2), c = 8.919(2) Å, α = 106.25(2), β = 99.56(1), γ = 108.80(2)°, and Z = 1. Compound II crystallizes in space group [Formula: see text] with a = 6.558(1), b = 7.134(2), c = 11.610(3) Å; α = 73.23(2), β = 78.08(2), γ = 72.67(2)°, and Z = 1. Compound III crystall

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24

Zhao, Huanyu, Anthony R. Prosser, Dennis C. Liotta, and Lawrence J. Wilson. "Discovery of novel N-aryl piperazine CXCR4 antagonists." Bioorganic & Medicinal Chemistry Letters 25, no. 21 (2015): 4950–55. http://dx.doi.org/10.1016/j.bmcl.2015.04.036.

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25

Chinh, Pham The, Pham Thi Tham, Duong Huong Quynh, et al. "Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties." Natural Product Communications 16, no. 4 (2021): 1934578X2110100. http://dx.doi.org/10.1177/1934578x211010040.

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Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), a

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26

Chaudhary, Preeti, Rupesh Kumar, Akhilesh K. Verma, et al. "Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives." Bioorganic & Medicinal Chemistry 14, no. 6 (2006): 1819–26. http://dx.doi.org/10.1016/j.bmc.2005.10.032.

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27

Mishra, Vaibhav, and Tejpal Singh Chundawat. "Pd Catalyzed N1/N4 Arylation of Piperazine for Synthesis of Drugs, Biological and Pharmaceutical Targets: An Overview of Buchwald Hartwig Amination Reaction of Piperazine in Drug Synthesis." Current Organic Synthesis 15, no. 2 (2018): 208–20. http://dx.doi.org/10.2174/1570179415666171206151603.

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Background: Substituted piperazine heterocycles are among the most significant structural components of pharmaceuticals. N1/N4 substituted piperazine containing drugs and biological targets are ranked 3rd in the top most frequent nitrogen heterocycles in U.S. FDA approved drugs. The high demand of N1/N4 substituted piperazine containing biologically active compounds and U.S. FDA approved drugs, has prompted the development of Pd catalyzed C-N bond formation reactions for their synthesis. Buchwald-Hartwig reaction is the key tool for the synthesis of these compounds. Objective: This review prov

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28

Gauci, Gabriel, and David C. Magri. "Solvent-polarity reconfigurable fluorescent 4-piperazino-N-aryl-1,8-naphthalimide crown ether logic gates." RSC Advances 12, no. 54 (2022): 35270–78. http://dx.doi.org/10.1039/d2ra07568g.

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29

Yamamoto, Yasuo, Keiichi Ajito, and Yasuo Ohtsuka. "Model Study for Preparation of Asymmetric N,N′-Disubstituted Piperazine Library: Efficient Synthesis of Aryl Piperazine and Benzyl Piperazine Derivatives on the Solid Support." Chemistry Letters 27, no. 5 (1998): 379–80. http://dx.doi.org/10.1246/cl.1998.379.

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30

Desai, Akshay D., and Kishor H. Chikhalia. "Synthesis and Studies of 1-[2-(Aryl Amino-2-Oxo Ethyl) Amino]-4-(N-Methyl Piperazino)-Benzene Derivatives." E-Journal of Chemistry 2, no. 1 (2005): 15–20. http://dx.doi.org/10.1155/2005/575290.

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1-[2-(Aryl Amino-2-Oxo Ethyl) Amino]-4-(N-Methyl Piperazino)-Benzene Derivatives were synthesized. The synthesized compounds were screened for their antibacterial activities againstS.auresandE.coliby cup plat method. From screening result some compounds found highly active against both Gram-positive and Gram-negative bacteria while other compounds possess feeble to moderate activity.

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31

Andronati, S. A., S. G. Soboleva, A. V. Zamkova, T. L. Karasyova, I. M. Rakipov, and D. I. Tsymbal. "[(N-Aryl)piperazinil]bythylpyrimidine derivatives with neurotropic and actoprotective properties." Journal of Organic and Pharmaceutical Chemistry 14, no. 1(53) (2016): 53–60. http://dx.doi.org/10.24959/ophcj.16.875.

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32

Beliaev, Alexandre, Humberto S. Ferreira, David A. Learmonth, et al. "Synthesis and structure–activity relationships of ionizable 1,3,4-oxadiazol-2(3H)-ones as peripherally selective FAAH inhibitors with improved aqueous solubility." Pure and Applied Chemistry 88, no. 4 (2016): 341–47. http://dx.doi.org/10.1515/pac-2016-0104.

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AbstractNovel 5-(2,4-difluorophenoxy)-3-aryl-1,3,4-oxadiazol-2(3H)-ones were prepared and in vivo SAR are discussed. Ionisable substituents on the N-phenyl ring provided compounds with significantly improved aqueous solubility. In addition, these analogues retained equivalent or improved potency against FAAH enzyme compared to the parent phenols 2–3. FAAH inhibition by the 2-(piperazin-1-yl)ethyl and 3-(piperazin-1-yl)propyl derivatives 24 and 30 was confined to the periphery in mice (30 mg/kg), whereas hepatic FAAH activity was inhibited by over 90%.

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33

Hunter, Naomi, Reid Tingley, Brad Peori, and Keith Vaughan. "Triazene derivatives of (1,x)-diazacycloalkanes. Part VIII. Synthesis and characterization of a series of 1,4-di[2-aryl-1-diazenyl]-2-methylpiperazines1." Canadian Journal of Chemistry 85, no. 3 (2007): 189–96. http://dx.doi.org/10.1139/v07-013.

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A series of 1,4-di-[2-aryl-1-diazenyl]-2-methylpiperazines (4a–n) have been synthesized by the reaction of 2-methylpiperazine with 2 equiv. of the appropriate diazonium salt. The products have been characterized by IR and NMR spectroscopy, and the molecular composition has been verified by HR-EIMS, with accurate mass measurement of the molecular ion. The presence of a chiral centre at C2 of the piperazine ring in the bistriazene 4 creates a multitude of diastereotopic protons in the methylene groups of the piperazine ring, as evidenced by the complexity of the NMR spectra, which nevertheless c

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34

Zhao, Xin, Mu Yuan, Biyun Huang, Hong Ji та Liu Zhu. "Ligand-based pharmacophore model of N-Aryl and N-Heteroaryl piperazine α1A-adrenoceptors antagonists using GALAHAD". Journal of Molecular Graphics and Modelling 29, № 2 (2010): 126–36. http://dx.doi.org/10.1016/j.jmgm.2010.05.002.

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35

Bosica, Giovanna, and Roderick Abdilla. "Novel Biopolymer-Based Catalyst for the Multicomponent Synthesis of N-aryl-4-aryl-Substituted Dihydropyridines Derived from Simple and Complex Anilines." Molecules 29, no. 8 (2024): 1884. http://dx.doi.org/10.3390/molecules29081884.

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Although Hantzsch synthesis has been an established multicomponent reaction method for more than a decade, its derivative, whereby an aniline replaces ammonium acetate as the nitrogen source, has not been explored at great length. Recent studies have shown that the products of such a reaction, N-aryl-4-aryldihydropyridines (DHPs), have significant anticancer activity. In this study, we successfully managed to synthesize a wide range of DHPs (18 examples, 8 of which were novel) using a metal-free, mild, inexpensive, recoverable, and biopolymer-based heterogeneous catalyst, known as piperazine,

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36

Ma, Yulu, Xi Zheng, Hui Gao, Chunping Wan, Gaoxiong Rao, and Zewei Mao. "Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety." Molecules 21, no. 12 (2016): 1684. http://dx.doi.org/10.3390/molecules21121684.

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37

Squires, Richard F., and Else Saederup. "Mono N-Aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: Implications for psychiatry." Neurochemical Research 18, no. 7 (1993): 787–93. http://dx.doi.org/10.1007/bf00966774.

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38

Chaudhary, Preeti, Surendra Nimesh, Veena Yadav, Akhilesh Kr Verma, and Rupesh Kumar. "Synthesis, characterization and in vitro biological studies of novel cyano derivatives of N-alkyl and N-aryl piperazine." European Journal of Medicinal Chemistry 42, no. 4 (2007): 471–76. http://dx.doi.org/10.1016/j.ejmech.2006.10.009.

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39

Mao, Ze-Wei, Xi Zheng, Yu-Ping Lin, et al. "Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine." Bioorganic & Medicinal Chemistry Letters 26, no. 15 (2016): 3421–24. http://dx.doi.org/10.1016/j.bmcl.2016.06.055.

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40

Desai, R. A., та S. D. Samant. "ChemInform Abstract: Preparation of N-[ω-(4-Aryl-1-piperazinyl)ethyl/propyl]-3-hydroxyphthalimidines". ChemInform 32, № 3 (2001): no. http://dx.doi.org/10.1002/chin.200103138.

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41

Jain, Manoj S., та Sanjay J. Surana. "Synthesis and evaluation of antipsychotic activity of 11-(4′-(N-aryl carboxamido/N-aryl-α-phenyl-acetamido)-piperazinyl)-dibenz[b,f][1,4]-oxazepine derivatives". Arabian Journal of Chemistry 10 (травень 2017): S2032—S2039. http://dx.doi.org/10.1016/j.arabjc.2013.07.033.

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42

Nishiyama, Masakazu, Toshihide Yamamoto, and Yasuyuki Koie. "Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst." Tetrahedron Letters 39, no. 7 (1998): 617–20. http://dx.doi.org/10.1016/s0040-4039(97)10659-1.

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43

McMillen, Brian A., Elizabeth A. Davanzo, Sara M. Scott, and Arleen H. Song. "N-alkyl-substituted aryl-piperazine drugs: Relationship between affinity for serotonin receptors and inhibition of aggression." Drug Development Research 12, no. 1 (1988): 53–62. http://dx.doi.org/10.1002/ddr.430120105.

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Jevtic, Ivana, Jelena Penjisevic, Katarina Savic-Vujovic та ін. "μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation". Journal of the Serbian Chemical Society 85, № 6 (2020): 711–20. http://dx.doi.org/10.2298/jsc190912118j.

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Abstract:

Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for ?-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperidine and N-aryl piperazine moieties, joined by a variable-length methylene linker. The two moieties represent MOR and D2DAR pharmacophores, respectively. The synthesis encompassed four steps, securing the final products in 28?42 % overall yields. The approach has a considerable synthetic potential, providing access to various related structures. Pharmacologic

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Yamamoto, Yasuo, Kiyoshi Tanabe, and Tsuneo Okonogi. "Application of Polymer Supported Base in Solid Phase Synthesis: Convenient Synthesis ofN-Aryl-N′-benzyl Piperazine Derivatives." Chemistry Letters 28, no. 2 (1999): 103–4. http://dx.doi.org/10.1246/cl.1999.103.

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NISHIYAMA, M., T. YAMAMOTO, and Y. KOIE. "ChemInform Abstract: Synthesis of N-Arylpiperazines from Aryl Halides and Piperazine under a Palladium Tri-tert-butylphosphine Catalyst." ChemInform 29, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.199820196.

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Sinha, Neelima, Sanjay Jain, Ajay Tilekar, et al. "Synthesis of isonicotinic acid N′-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents." Bioorganic & Medicinal Chemistry Letters 15, no. 6 (2005): 1573–76. http://dx.doi.org/10.1016/j.bmcl.2005.01.073.

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Bosc, Jean Jacques, and Christian Jarry. "Synthesis and Pharmacological Evaluation ofN-Phenyl-N′-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas." Archiv der Pharmazie 331, no. 9 (1998): 291–93. http://dx.doi.org/10.1002/(sici)1521-4184(19989)331:9<291::aid-ardp291>3.0.co;2-r.

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Kumar, Sushil, A. K. Wahi, and Ranjit Singh. "Synthesis, computational studies and preliminary pharmacological evaluation of 2–[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides as potential antipsychotics." European Journal of Medicinal Chemistry 46, no. 9 (2011): 4753–59. http://dx.doi.org/10.1016/j.ejmech.2011.07.028.

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Foroumadi, Alireza, Fatemeh Soltani, Mohammad Hasan Moshafi, and Rogheeyeh Ashraf-Askari. "Synthesis and in vitro antibacterial activity of some N-(5-aryl-1,3,4-thiadiazole-2-yl)piperazinyl quinolone derivatives." Il Farmaco 58, no. 10 (2003): 1023–28. http://dx.doi.org/10.1016/s0014-827x(03)00191-5.

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