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Journal articles on the topic 'N-Methylpiperazine'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sarbu, Laura Gabriela. "SYNTHESIS OF 1,3-DITHIOLIUM SALTS CONTAINING N-METHYLPIPERAZINE." ACTA CHEMICA IASI 31, no. 2 (2024): 119–28. http://dx.doi.org/10.47743/achi-2023-2-0008.

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The synthesis of 4-aryl-2-(N-methylpiperazin-1-yl)-1,3-dithiol-2-ylium perchlorates has been accomplished by the acid catalyzed heterocyclocondensation of the corresponding substituted phenacyl N-methylpiperazin-1-carbodithioates. The later have been obtained from the reaction of various substituted -bromoacetophenones with a salt of N-methylpiperazine carbodithioic acid. The structures of new synthesized N-methylpiperazine derivatives have been proved by analytical and spectral data.

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2

ASHOK, KUMAR, SHARMA PRATIBHA, NATI-1. MISHRA NIRANKAR, and NARAD SANDEEP. "Electrochemical Way of Functioning of Cadmium(II) and Nickel(II) with N-Methylpiperazine at DME." Journal of Indian Chemical Society Vol. 72, Dec 1995 (1995): 889–91. https://doi.org/10.5281/zenodo.5900851.

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Institute of Chemical Sciences, Devi Ahilya Vishwavidyalaya, lndore-452 001 <em>Manuscript received 19 October 1993, revised 18 February 1994, accepted 18 May 1994</em> Electrochemical Way of Functioning of Cadmium(II) and Nickel(II) with N-Methylpiperazine at DME

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3

Vejdělek, Zdeněk, and Miroslav Protiva. "N-(piperazinoacyl) and N-(piperazinoalkyl) derivatives of 4-cyclopentylaniline and related compounds: Synthesis and pharmacological screening." Collection of Czechoslovak Chemical Communications 51, no. 7 (1986): 1494–502. http://dx.doi.org/10.1135/cccc19861494.

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Five N-(4-cyclopentylphenyl)haloalkanecarboxamides were reacted with 1-methylpiperazine and 1-(2-hydroxyethyl)piperazine to give the corresponding N-(4-cyclopentylphenyl)piperazinoalkanecarboxamides Iab -Vab. Their reduction with lithium aluminium hydride afforded the triamines VIIab - XIab. Acylation of the N-(4-methylpiperazino)alkyl-4-cyclopentylanilines Xa and XIa with propionyl chloride resulted in the propionanilides XIVa and XVa, whereas a similar reaction of the N-(4-(2-hydroxyethyl)piperazino)alkyl-4-cyclopentylanilines VIIb and IXb - XIb produced the propionoxypropionanilides XIIc -

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4

Hulinská, Hana, Miloš Buděšínský, Jiří Holubek, Oluše Matoušová, Hana Frycová, and Miroslav Protiva. "Reactions of N-substituted 2-aminopyridines with chloroacetyl chloride; Formation of a new series of heterocyclic betaines: 1-Substituted 4-chloromethyl-2-oxopyrido[1,2-a]pyrimidin-5-ium-3-olates." Collection of Czechoslovak Chemical Communications 54, no. 5 (1989): 1376–87. http://dx.doi.org/10.1135/cccc19891376.

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N-(2-Pyridyl)-2-chloroacetamide reacted with 1-methylpiperazine and gave the expected compound III. Attempts at preparing the N-substituted N-(2-pyridyl)-2-chloroacetamides by reactions of N-substituted 2-aminopyridines with chloroacetyl chloride in benzene in the presence of N,N-dimethylacetamide were negative and took an unexpected course. 2-Anilinopyridine and 2-(cyclohexylamino)pyridine afforded compounds which were identified by 1H and 13C NMR spectra as the heterocyclic betaines IVa and IVb. 2-(1-Butylamino)pyridine, 2-(benzylamino)pyridine and 2-(2-phenylethylamino)pyridine gave similar

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5

Rádl, Stanislav. "Synthetic Studies Connected with the Preparation of 4-Cyclopropyl-7-fluoro-6-(4-methylpiperazin-1-yl)-1,2,4,9-tetrahydrothiazolo[5,4-b]quinoline-2,9-dione." Collection of Czechoslovak Chemical Communications 62, no. 5 (1997): 791–99. http://dx.doi.org/10.1135/cccc19970791.

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Target 4-cyclopropyl-7-fluoro-6-(4-methylpiperazin-1-yl)-1,2,4,9-tetrahydrothiazolo[5,4-b]quinoline-2,9-dione (5a) was obtained from 3-amino-1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)-2-mercaptoquinolin-4(1H)-one (9b). This intermediate was obtained from 3-amino-1-cyclopropyl- 6,7-difluoro-2-(methylsulfinyl)quinolin-4(1H)-one (9f) via 3-amino-1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)-2-(methylsulfinyl)quinolin-4(1H)-one (9c). Compound 9f was prepared from 2,4,5-trifluoroacetophenone (6a) in several steps. 4-Cyclopropyl-6,7-difluoro-2,3,4,9-tetrahydrothiazolo[5,4-b]quinoline-3,4-

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6

Alanazi, Amer M., Ali A. El-Emam, Nasser R. El-Brollosy, Seik Weng Ng, and Edward R. T. Tiekink. "4-Benzyl-N-methylpiperazine-1-carbothioamide." Acta Crystallographica Section E Structure Reports Online 68, no. 3 (2012): o712—o713. http://dx.doi.org/10.1107/s1600536812005685.

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7

Khusnutdinova, Elmira F., Anastasiya V. Petrova, Olga S. Kukovinets, and Oxana B. Kazakova. "Synthesis and Cytotoxicity of 28-N-Propargylaminoalkylated 2,3-Indolotriterpenic acids." Natural Product Communications 13, no. 6 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300603.

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A new series of propargylaminoalkyl derivatives with N-methylpiperazine and morpholine fragments was obtained by modification of the carboxyl group of [3,2b]-indolotriterpenic acids ( N-propargylation, Cu(I) catalyzed Mannich reaction). Cytotoxicity assays demonstrated that oleanane-type conjugate with N-methylpiperazine exhibited high antitumor activity against leukemia cell line SR and non-small cell lung cancer cell line NCI-H460.

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8

Li, Yu-Feng, and Wen-Mei Wang. "N-(4-Chlorophenyl)-4-methylpiperazine-1-carboxamide." Acta Crystallographica Section E Structure Reports Online 67, no. 9 (2011): o2453. http://dx.doi.org/10.1107/s1600536811034283.

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9

Coşkun, Mehmet, Gamze Barim, and Kadir Demirelli. "Thermal Stabilities of Poly(N‐acryloyl‐N′‐methylpiperazine), its Blends With Poly(methyl methacrylate), and Poly(N‐acryloyl‐N′‐methylpiperazine‐co‐methyl methacrylate)." Journal of Macromolecular Science, Part A 43, no. 1 (2006): 83–93. http://dx.doi.org/10.1080/10601320500405950.

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10

Martín-Gomis, Luis, Nikos Karousis, Fernando Fernández-Lázaro, et al. "Exfoliation and supramolecular functionalization of graphene with an electron donor perylenediimide derivative." Photochemical & Photobiological Sciences 16, no. 4 (2017): 596–605. http://dx.doi.org/10.1039/c6pp00351f.

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11

Koroleva, E. V., K. N. Gusak, Zh V. Ignatovich, and A. L. Ermolinskaya. "Synthesis of new amides of the N-methylpiperazine series." Russian Journal of Organic Chemistry 47, no. 10 (2011): 1556–63. http://dx.doi.org/10.1134/s1070428011100198.

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12

Freeman, Stephanie A., Xi Chen, Thu Nguyen, Humera Rafique, Qing Xu, and Gary T. Rochelle. "Piperazine/N-methylpiperazine/N,N’-dimethylpiperazine as an Aqueous Solvent for Carbon Dioxide Capture." Oil & Gas Science and Technology – Revue d’IFP Energies nouvelles 69, no. 5 (2013): 903–14. http://dx.doi.org/10.2516/ogst/2012089.

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13

Khusnutdinova, Elmira F., Anastasiya V. Petrova, Gulnaz M. Bashirova, and Oxana B. Kazakova. "N-Propargylation of Indolo-Triterpenoids and Their Application in Mannich Reaction." Molbank 2019, no. 2 (2019): M1065. http://dx.doi.org/10.3390/m1065.

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The introduction of the alkynyl moiety to the triterpenic core through a linkage to the indole nitrogen is described. The reaction of N-propargylindoles with N-methylpiperazine using Mannich reaction led to propargylaminoalkynyl-triterpenoids, whose structures were established by NMR spectroscopy.

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14

Hunter, Naomi, Reid Tingley, Brad Peori, and Keith Vaughan. "Triazene derivatives of (1,x)-diazacycloalkanes. Part VIII. Synthesis and characterization of a series of 1,4-di[2-aryl-1-diazenyl]-2-methylpiperazines1." Canadian Journal of Chemistry 85, no. 3 (2007): 189–96. http://dx.doi.org/10.1139/v07-013.

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A series of 1,4-di-[2-aryl-1-diazenyl]-2-methylpiperazines (4a–n) have been synthesized by the reaction of 2-methylpiperazine with 2 equiv. of the appropriate diazonium salt. The products have been characterized by IR and NMR spectroscopy, and the molecular composition has been verified by HR-EIMS, with accurate mass measurement of the molecular ion. The presence of a chiral centre at C2 of the piperazine ring in the bistriazene 4 creates a multitude of diastereotopic protons in the methylene groups of the piperazine ring, as evidenced by the complexity of the NMR spectra, which nevertheless c

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15

BABA, Hajime, Takashi ABE, and Eiji HAYASHI. "Electrochemical fluorination of N-methylpiperazine and 1-methylhexahydro-1,4-diazepine." NIPPON KAGAKU KAISHI, no. 9 (1986): 1249–51. http://dx.doi.org/10.1246/nikkashi.1986.1249.

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16

Barakat, Assem, Saied M. Soliman, Matti Haukka та ін. "One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone". Crystals 10, № 4 (2020): 282. http://dx.doi.org/10.3390/cryst10040282.

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One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved. The synthetic protocol via three components reaction of p-chloroacetophenone with DMFDMA (N,N-dimethylformamid-dimethylacetal) and the corresponding secondary amines (morpholine/N-methylpiperazine/pyrrolidine) in dioxane under heating for 2.5–4 h at 102 °C yielded the requisite enaminones. This protocol has the advantage of no separation of intermediate, no

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17

Liu, Y., S. H. Goh, S. Y. Lee, and C. H. A. Huan. "Spectroscopic studies of interactions in poly(N-acryloyl-N?-methylpiperazine)/acidic polymer complexes." Journal of Polymer Science Part B: Polymer Physics 38, no. 4 (2000): 501–8. http://dx.doi.org/10.1002/(sici)1099-0488(20000215)38:4<501::aid-polb1>3.0.co;2-b.

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18

Marzotto, A., D. A. Clemente, and G. Valle. "Piperazine (and Derivatives) Platinum(II) Complexes:trans-Bis(N-methylpiperazine-N,N')platinum(II) Dichloride Tetrahydrate." Acta Crystallographica Section C Crystal Structure Communications 53, no. 11 (1997): 1580–83. http://dx.doi.org/10.1107/s0108270197007506.

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19

Ciccarese, A., D. A. Clemente, F. P. Fanizzi, A. Marzotto, and G. Valle. "Platinum(II) Complexes of Piperazine (and Derivatives):cis-Diiodo(N-methylpiperazine-N,N')platinum(II)." Acta Crystallographica Section C Crystal Structure Communications 54, no. 12 (1998): 1779–81. http://dx.doi.org/10.1107/s0108270198009755.

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20

Żesławska, Ewa, Wojciech Nitek, Waldemar Tejchman, and Jadwiga Handzlik. "Influence of 3-{5-[4-(diethylamino)benzylidene]rhodanine}propionic acid on the conformation of 5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-4(5H)-one." Acta Crystallographica Section C Structural Chemistry 74, no. 11 (2018): 1427–33. http://dx.doi.org/10.1107/s2053229618013980.

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The arylidene–imidazolone derivatives are a group of compounds of great interest in medicinal chemistry due to their various pharmacological actions. In order to study the possible conformations of an arylidene–imidazolone derivative, two new crystal structures were determined by X-ray diffraction, namely (Z)-5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-5(4H)-one, C15H17ClN4O, (6), and its salt 4-[5-(4-chlorobenzylidene)-5-oxo-4,5-dihydro-3H-imidazol-2-yl]-1-methylpiperazin-1-ium 3-{5-[4-(diethylamino)benzylidene]-4-oxo-2-thioxothiazolidin-3-yl}propionate, C15H18ClN4O+·C17H19

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21

Nagaiah, K., A. S. Rao, S. J. Kulkarni, M. Subrahmanyam, and A. V. R. Rao. "Intermolecular Cyclization of Diethanolamine and Methylamine to N-Methylpiperazine over Zeolites." Journal of Catalysis 147, no. 1 (1994): 349–51. http://dx.doi.org/10.1006/jcat.1994.1147.

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22

Marzotto, A., D. A. Clemente, and G. Valle. "Platinum(II) Complexes of Piperazine (and Derivatives):trans-Dichlorobis(N-methylpiperazine-N')platinum(II)." Acta Crystallographica Section C Crystal Structure Communications 54, no. 1 (1998): 27–29. http://dx.doi.org/10.1107/s0108270197012353.

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23

Petrova, A. V. "Synthesis and aminomethylation of A-azepanederivatives of uvaol and betulin." Журнал органической химии 59, no. 1 (2023): 133–38. http://dx.doi.org/10.31857/s0514749223010123.

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By stepwise conjugation of biologically active A-azepanobetulin or A-azepanouvaol with succinic anhydride and propargylamine, followed by a Cu-catalyzed Mannich reaction, new hybrid derivatives with an N -methylpiperazine fragment were synthesized with an average yield of 73%. The structure of the obtained compounds was established using NMR spectroscopy.

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24

Loh, X. J., G. Roshan Deen, Y. Y. Gan, and L. H. Gan. "Water-sorption and metal-uptake behavior of pH-responsive poly (N-acryloyl-N?-methylpiperazine) gels." Journal of Applied Polymer Science 80, no. 2 (2001): 268–73. http://dx.doi.org/10.1002/1097-4628(20010411)80:2<268::aid-app1095>3.0.co;2-i.

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25

Jagan, R., D. Sathya, and K. Sivakumar. "A dihydrogen phosphate anionic network as a host lattice for cations in 1-methylpiperazine-1,4-diium bis(dihydrogen phosphate) and 2-(pyridin-2-yl)pyridinium dihydrogen phosphate–orthophosphoric acid (1/1)." Acta Crystallographica Section C Structural Chemistry 71, no. 5 (2015): 374–80. http://dx.doi.org/10.1107/s2053229615006518.

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In the salt 1-methylpiperazine-1,4-diium bis(dihydrogen phosphate), C5H13N22+·2H2PO4−, (I), and the solvated salt 2-(pyridin-2-yl)pyridinium dihydrogen phosphate–orthophosphoric acid (1/1), C10H9N2+·H2PO4−·H3PO4, (II), the formation of O—H...O and N—H...O hydrogen bonds between the dihydrogen phosphate (H2PO4−) anions and the cations constructs a three- and two-dimensional anionic–cationic network, respectively. In (I), the self-assembly of H2PO4−anions forms a two-dimensional pseudo-honeycomb-like supramolecular architecture along the (010) plane. 1-Methylpiperazine-1,4-diium cations are trap

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26

Iriepa, I., A. I. Madrid, E. Gálvez, and J. Bellanato. "Synthesis, structural and conformational study of some amides derived from N-methylpiperazine." Journal of Molecular Structure 787, no. 1-3 (2006): 8–13. http://dx.doi.org/10.1016/j.molstruc.2005.10.025.

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27

Xie, Xiaoyi, and Thieo E. Hogen-Esch. "Anionic Synthesis of Narrow Molecular Weight Distribution Water-Soluble Poly(N,N-dimethylacrylamide) and Poly(N-acryloyl-N ‘-methylpiperazine)." Macromolecules 29, no. 5 (1996): 1746–52. http://dx.doi.org/10.1021/ma950688d.

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28

Estévez-Sarmiento, Francisco, Ester Saavedra, Ignacio Brouard, et al. "Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells." International Journal of Molecular Sciences 23, no. 24 (2022): 15518. http://dx.doi.org/10.3390/ijms232415518.

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In this study, we investigated the effects of eleven synthetic guanidines containing the 1,3-diphenylpropenone core on the viabilities of six human cancer cells. The most cytotoxic compound against human cancer cells of this series contains a N-tosyl group and a N-methylpiperazine moiety 6f. It was cytotoxic against leukemia cells (U-937, HL-60, MOLT-3, and NALM-6) with significant effects against Bcl-2-overexpressing U-937/Bcl-2 cells as well as the human melanoma SK-MEL-1 cell line. It exhibited low cytotoxicity against quiescent or proliferating human peripheral blood mononuclear cells. The

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29

Rivas, Bernab� L., S. Amalia Pooley, and Maribel Luna. "Ultrafiltration of metal ions by water-soluble chelating poly(N-acryloyl-N-methylpiperazine-co-N-acetyl-?-aminoacrylic acid)." Journal of Applied Polymer Science 83, no. 12 (2002): 2556–61. http://dx.doi.org/10.1002/app.10207.

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30

Matos, Ana M., Teresa Man, Imane Idrissi та ін. "Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions". Pure and Applied Chemistry 91, № 7 (2019): 1107–36. http://dx.doi.org/10.1515/pac-2019-0114.

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Abstract With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key player in amyloid β oligomer (Aβo)-induced neurodegeneration, we investigated whether the neuroprotective potential of nature-inspired flavonoids against Aβ-promoted toxicity would translate into the ability to disrupt PrPC-Aβo interactions. Hence, we synthesized a small library of flavones and studied their binding affinity towards Aβo by STD-N

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31

Petrova, Anastasiya V., Irina E. Smirnova, Sergey V. Fedij, et al. "Synthesis and Inhibition of Influenza H1N1 Virus by Propargylaminoalkyl Derivative of Lithocholic Acid." Molbank 2023, no. 2 (2023): M1626. http://dx.doi.org/10.3390/m1626.

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In the current study, the conjugate of 3-oxo-lithocholic acid with N-methylpiperazine and paraform was synthesized using the Mannich reaction and evaluated for antiviral activity. This modification resulted in a dramatic increase of antiviral activity combined with a two-fold decrease of toxicity. Together, these effects led to a strong increase of selectivity of compound (SI = 40 vs. 3 for 3 and 2, correspondingly).

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32

Lukevits, �., T. V. Lapina, I. D. Segal, I. S. Augustane, and V. N. Verovskii. "Synthesis and antiblastic activity of organosilicon derivatives of quinoline, isoquinoline, and N-methylpiperazine." Pharmaceutical Chemistry Journal 22, no. 8 (1988): 619–23. http://dx.doi.org/10.1007/bf00763626.

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33

NAGAIAH, K., A. S. RAO, S. J. KULKARNI, M. SUBRAHMANYAM, and A. V. R. RAO. "ChemInform Abstract: Intermolecular Cyclization of Diethanolamine and Methylamine to N- Methylpiperazine Over Zeolites." ChemInform 25, no. 33 (2010): no. http://dx.doi.org/10.1002/chin.199433199.

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34

Lin, Hui-Hui, Xiao-Lin Zheng, and Sheng-Li Cao. "5-Methyl-3,3-bis(4-methylpiperazin-1-yl)-1-[2-(4-methylpiperazin-1-yl)ethyl]indolin-2-one." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1855. http://dx.doi.org/10.1107/s1600536812022416.

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In the title compound, C26H43N7O, each piperazine ring adopts a chair conformation. Two 1-methylpiperazine rings bond to one Csp 3 of the pyrrole ring via the piperazine N atoms, while the third one links to the N atom of the indolin-2-one unit through a flexible ethyl group with an almost syn conformation. In the crystal, molecules are connected through methylene–carbonyl C—H...O interactions into an infinite chain along the c axis. The almost parallel arrays are stacked, forming a three-dimensional framework.

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35

Liu, Yong, S. H. Goh, S. Y. Lee, and C. H. A. Huan. "Miscibility and Interactions in Blends and Complexes of Poly(N-acryloyl-N‘-methylpiperazine) with Poly(p-vinylphenol)." Macromolecules 32, no. 6 (1999): 1967–71. http://dx.doi.org/10.1021/ma9814200.

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36

Malavašič, Črt, Jernej Wagger, Branko Stanovnik, and Jurij Svete. "(S)-N-Benzyl-3(6)-methylpiperazine-2,5-diones as chiral solvating agents for N-acylamino acid esters." Tetrahedron: Asymmetry 19, no. 13 (2008): 1557–67. http://dx.doi.org/10.1016/j.tetasy.2008.06.013.

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37

Olszewska, E., B. Tarasiuk, and S. Pikus. "New powder diffraction data of some N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide-potential pesticides." Powder Diffraction 26, no. 4 (2011): 337–45. http://dx.doi.org/10.1154/1.3652921.

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N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide—2-(4-chloro-3,5-dimethylphenoxy)-N-(4-fluorophenyl)acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(3-chloro-4-fluorophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-chloro-3-(trifluoromethyl)phenyl] acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[3-chloro-4-methylphenyl]acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(2,4,6-tribromophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-pyridin-2-ylacetamide, 1-[(4-chloro-3,5-dimethylphenoxy)acetyl]-4-methylpiperazine, and 1-benzyl-4-[(4-chloro-3,5-dimethylphenoxy)acetyl]piperazine—have

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38

Rádl, Stanislav, and Lenka Kovářová. "Some reactions of N-propadienyl-4-quinolones." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2413–19. http://dx.doi.org/10.1135/cccc19912413.

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N-Alkylation of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Vg) with 3-bromopropyne followed by acidic hydrolysis provided N-propyl derivative Ic which in alkaline media yielded N-propadienyl derivative IId. Propadienyl derivatives IIa and IIb treated with primary or secondary amines provided intermediates IIIa-IIIc which were hydrolyzed to N-acetonyl derivatives IVa and IVb, respectively. N-Benzylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Va) followed by hydrolysis yielded 1-benzyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic ac

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39

Balakrishna, Maravanji S., D. Suresh, Paulose P. George, and Joel T. Mague. "Aminophosphines derived from morpholine and N-methylpiperazine: Synthesis, oxidation reactions and transition metal complexes." Polyhedron 25, no. 16 (2006): 3215–21. http://dx.doi.org/10.1016/j.poly.2006.05.041.

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40

Tafazzoli, Mohsen, Cristina Suarez, Nancy S. True, Clifford B. LeMaster, and Carol L. LeMaster. "The ring inversion of gaseous N-methylpiperazine. Pressure and temperature dependent 1H NMR studies." Journal of Molecular Structure 317, no. 1-2 (1994): 137–45. http://dx.doi.org/10.1016/0022-2860(93)07869-x.

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41

Keglevich, András, Leonetta Dányi, Alexandra Rieder, et al. "Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores." Molecules 25, no. 4 (2020): 1010. http://dx.doi.org/10.3390/molecules25041010.

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New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole derivative, morpholine, piperazine and N-methylpiperazine. The structure of the new compounds was characterized by NMR spectroscopy and mass spectrometry (MS). Several compounds exhibited in vitro antiproliferative activity against human gynecological cancer cell lines with IC50 values in the low micromolar concentration range.

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Seurot, Alexandre, Antoine Hoang, Vincent Jousseaume, and Paul-Henri Haumesser. "Toward Thin Dielectric Films of Polyetherimide Electrodeposited from Aqueous Emulsions of the Polymer." ECS Meeting Abstracts MA2023-01, no. 22 (2023): 1573. http://dx.doi.org/10.1149/ma2023-01221573mtgabs.

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Miniaturized, high power electronic devices are needed for a variety of applications. Although, the miniaturization of these devices is challenging. For instance, high power capacitors need to sustain high electric fields, with typically several hundred volts across micrometric dielectric layers. Among the most promising materials for this application, polyetherimide (PEI) has a number of desired characteristics such as adequate electrical properties, good chemical and mechanical resistance with thermal stability up to 170°C. Spin-coating is the conventional technique used in the microelectron

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Yeromina, Hanna, Nataliya Demchenko, Olga Kiz, Zinaida Ieromina, and Sergiy Demchenko. "The Synthesis and Antimicrobial Properties of New 2-(R-Phenylimino)-1,3-thiazoline Derivatives Containing the N-Methylpiperazine Moiety." Chemistry & Chemical Technology 13, no. 2 (2019): 150–56. http://dx.doi.org/10.23939/chcht13.02.150.

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Hulinská, Hana, Zdeněk Polívka, Jiří Jílek, et al. "Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1820–44. http://dx.doi.org/10.1135/cccc19881820.

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Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)-dibenz[b,f]azepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V-XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I). Contributions to the syntheses and characterization of mianserin (XIX),

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Zonjić, Iva, Marijana Radić Stojković, Ivo Crnolatac, et al. "Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents." Bioorganic Chemistry 127 (October 2022): 105999. http://dx.doi.org/10.1016/j.bioorg.2022.105999.

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Grguric-Sipka, Sanja, Arbi Alshtewi, Dejan Jeremic, et al. "Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes." Journal of the Serbian Chemical Society 73, no. 6 (2008): 619–30. http://dx.doi.org/10.2298/jsc0806619g.

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Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(?6-p-cymene)RuCl2(CH3NH(CH2)4NH)]PF6, complex 1) or vitamin K3-thiosemicarbazone ([(?6-p-cymene)RuCl2(K3tsc)], complex 2) were synthesized starting from [(?6-p-cymene)2RuCl2]2 and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed ?piano-stool? geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand presen

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Rádl, Stanislav, and Viktor Zikán. "Synthesis of some 1-aryl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their antibacterial activity." Collection of Czechoslovak Chemical Communications 54, no. 8 (1989): 2181–89. http://dx.doi.org/10.1135/cccc19892181.

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1,4-Dihydro-4-oxoquinoline-3-carboxylic acids VIIIc and VIIId were prepared via their ethyl esters VIIIa and VIIIb, which were obtained by a direct arylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (VIa). When treated with piperazine or N-methylpiperazine compound VIIId yields VIIIe or VIIIf, respectively. Reduction of VIIId, VIIIe, and VIIIf with ferrous sulfate yields VIIIg, VIIIh, and VIIIi, respectively. Diazotization and introduction of fluorine into VIIIg using hydrogen fluoride-pyridine yields VIIIj. The compounds prepared were tested for their antimicrobial

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K., S. Nimavat, H. Popat K., L. Vasoya S., and S. Joshi H. "Synthesis and antimicrobial activity of some new aminobenzylated Mannich bases." Journal of Indian Chemical Society Vol. 80, July 2003 (2003): 711–13. https://doi.org/10.5281/zenodo.5835566.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, India <em>E-mail</em> : drhsjoshi@yahoo.com                  <em> Fax:</em> 91-281-578512 <em>Manuscript received 4 April 2002, revised 1 January 2003, accepted 21 March 2003</em> 3-Bromobenzaldehyde has been condensed with piperidine, morpholine, indole, <em>N</em>-methylpiperazine to give intermediate Ncyclic phenylcarbinols which on condensation with acetamide, urea and thiourea, having active hydrogen functions, give the new aminobenzylated Mannich bases (1a-d, 2a-d, 3a-d). The

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Harbers, M., and H. Hilz. "Suppression of c-fos precursor RNA splicing by the protein kinase C inhibitor H7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine]." Biochemical Journal 278, no. 1 (1991): 305–8. http://dx.doi.org/10.1042/bj2780305.

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In JB6 epidermal cells, induction of fos proto-oncogene expression by phorbol 12-myristate 13-acetate can be inhibited by the protein kinase C (PKC) inhibitor H7 [1-5(isoquinolinesulphonyl)-2-methylpiperazine]. The compound causes also a dose-dependent suppression of fos precursor RNA splicing which, however, appears to react somewhat less sensitively to H7 than does PKC activity. This indicates that H7-induced accumulation of fos precursor RNA is not due to inhibition of PKC. Support for this interpretation comes from the finding that other inhibitors of PKC, such as N-(2-guanidinoethyl)-5-is

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Richards, A. L., and J. Y. Djeu. "Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line." Journal of Immunology 145, no. 9 (1990): 3144–49. http://dx.doi.org/10.4049/jimmunol.145.9.3144.

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Abstract Using a cloned murine cell line, NKB61A2, that concomitantly exhibits both NK and natural cytotoxic (NC) activities, we investigated the biochemical mechanisms involved in natural cell mediated cytotoxicity against NK-sensitive YAC-1 tumor cells and against the NC-sensitive WEHI-164 tumor cells. Recent reports have suggested that target cell lysis by cytotoxic lymphocytes occurs by either a calcium dependent and/or a calcium-independent mechanism(s). To determine the role of calcium in NK and NC activities of the NKB61A2 cell line, we evaluated the effect of: 1) extracellular Ca2+ dep

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