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Journal articles on the topic 'N-Phenylanthranilic Acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Martín, Ana, Rolando F. Pellón, Miriam Mesa, Maite L. Docampo, and Victoria Gómez. "Microwave-assisted Synthesis of N-phenylanthranilic Acids in Water." Journal of Chemical Research 2005, no. 9 (2005): 561–63. http://dx.doi.org/10.3184/030823405774308998.

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N-Phenylanthranilic acid derivatives were synthesised using the Ullmann condensation of 2-chlorobenzoic acid with aniline derivatives under microwave irradiation in aqueous media. The method offers better yields in shorter reaction times compared to classical heating approaches using water as solvent.

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2

Bala, Madhu, Rachna Yadav, and Amit Girdhar. "Synthesis and Characterization of Ester Derivatives of N-Phenylanthranilic Acid." Asian Journal of Chemistry 36, no. 10 (2024): 2269–74. http://dx.doi.org/10.14233/ajchem.2024.32215.

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N-Phenylanthranilic acid (fenamic acid) serves as the fundamental structure for synthesizing several non-steroidal anti-inflammatory drugs, antibacterial drugs and also functions as a modulator of membrane transport. To reduce the dose-related side effects of existing drugs, research is focussing to improve fenamic acid derivative solubility and bioavailability. A series of ester derivatives of N-phenylanthranilic acid (MB-1 to MB-5) viz. 2-(phenyl amino)methyl benzoate, 2-(phenyl amino)ethyl benzoate, 2-(phenyl amino)isopropyl benzoate,2-(phenyl amino)butyl benzoate and 2-(phenyl amino)phenyl

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3

Gaidukevich, A. N., E. Ya Levitin, A. A. Kravchenko, et al. "Synthesis and biological activity of N-phenylanthranilic acid derivatives." Pharmaceutical Chemistry Journal 19, no. 3 (1985): 180–82. http://dx.doi.org/10.1007/bf00770449.

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4

Ozkan, S. Zh, I. S. Eremeev, G. P. Karpacheva, and G. N. Bondarenko. "Oxidative Polymerization of N-Phenylanthranilic Acid in the Heterophase System." Open Journal of Polymer Chemistry 03, no. 03 (2013): 63–69. http://dx.doi.org/10.4236/ojpchem.2013.33012.

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5

Almasirad, Ali, Rohollah Hosseini, Hassan Jalalizadeh, et al. "Synthesis and Analgesic Activity of 2-Phenoxybenzoic Acid and N-Phenylanthranilic Acid Hydrazides." Biological & Pharmaceutical Bulletin 29, no. 6 (2006): 1180–85. http://dx.doi.org/10.1248/bpb.29.1180.

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6

Svechnikova, O. M., S. V. Kolisnyk, O. F. Vinnyk, T. A. Kostina, and T. V. Zhukova. "The molecular design of biologically active derivatives of N-phenylanthranilic acid." Journal of Organic and Pharmaceutical Chemistry 16, no. 1(61) (2018): 49–53. http://dx.doi.org/10.24959/ophcj.18.937.

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7

Wang, Yi-Xiang J., Graham Betton, Eike Floettmann, and Carsten Liess. "MRI histopathology correlation of N-phenylanthranilic acid induced nephropathy in rats." British Journal of Radiology 79, no. 948 (2006): 1009–10. http://dx.doi.org/10.1259/bjr/47913384.

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8

Hamiaux, Cyril, Lesley Larsen, Hui Wen Lee, et al. "Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode." Biochemical Journal 476, no. 12 (2019): 1843–56. http://dx.doi.org/10.1042/bcj20190288.

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Abstract Strigolactones (SLs) are multifunctional plant hormones regulating essential physiological processes affecting growth and development. In vascular plants, SLs are recognized by α/β hydrolase-fold proteins from the D14/DAD2 (Dwarf14/Decreased Apical Dominance 2) family in the initial step of the signaling pathway. We have previously discovered that N-phenylanthranilic acid derivatives (e.g. tolfenamic acid) are potent antagonists of SL receptors, prompting us to design quinazolinone and quinazolinedione derivatives (QADs and QADDs, respectively) as second-generation antagonists. Initia

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9

Ozkan, Sveta Zhiraslanovna, Lyudmila Ivanovna Tkachenko, Oleg Nikolaevich Efimov, et al. "Advanced Electrode Coatings Based on Poly-N-Phenylanthranilic Acid Composites with Reduced Graphene Oxide for Supercapacitors." Polymers 15, no. 8 (2023): 1896. http://dx.doi.org/10.3390/polym15081896.

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The electrochemical behavior of new electrode materials based on poly-N-phenylanthranilic acid (P-N-PAA) composites with reduced graphene oxide (RGO) was studied for the first time. Two methods of obtaining RGO/P-N-PAA composites were suggested. Hybrid materials were synthesized via in situ oxidative polymerization of N-phenylanthranilic acid (N-PAA) in the presence of graphene oxide (GO) (RGO/P-N-PAA-1), as well as from a P-N-PAA solution in DMF containing GO (RGO/P-N-PAA-2). GO post-reduction in the RGO/P-N-PAA composites was carried out under IR heating. Hybrid electrodes are electroactive

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10

Endo, Satoshi, Toshiyuki Matsunaga, Midori Soda, et al. "Selective Inhibition of the Tumor Marker AKR1B10 by Antiinflammatory N-Phenylanthranilic Acids and Glycyrrhetic Acid." Biological & Pharmaceutical Bulletin 33, no. 5 (2010): 886–90. http://dx.doi.org/10.1248/bpb.33.886.

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11

Wang, Ying, Huan Yuan, Dongyun Ma, Yunjie Zhang, Shujing Zhou, and Jie Zhang. "Synthesis Characterization and Fluorescence Property of Terbium(III) Complexes with N-phenylanthranilic Acid." IOP Conference Series: Materials Science and Engineering 436 (October 23, 2018): 012024. http://dx.doi.org/10.1088/1757-899x/436/1/012024.

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12

Tan, Yu-Hui, Jian-Bo Xiong, Ji-Xing Gao, et al. "Synthesis, crystal structures, and properties of three metal complexes with N-phenylanthranilic acid." Journal of Molecular Structure 1086 (April 2015): 49–55. http://dx.doi.org/10.1016/j.molstruc.2015.01.005.

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13

Rajendiran, N., та T. Balasubramanian. "Dual fluorescence of N-phenylanthranilic acid: Effect of solvents, pH and β-cyclodextrin". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 68, № 3 (2007): 867–76. http://dx.doi.org/10.1016/j.saa.2006.12.072.

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14

Taş, Murat, Okan Zafer Yeşilel, and Orhan Büyükgüngör. "Novel Copper(II) Complexes of N-Phenylanthranilic Acid Containing Ethanol and Hydroxo Ligands." Journal of Inorganic and Organometallic Polymers and Materials 20, no. 2 (2010): 298–305. http://dx.doi.org/10.1007/s10904-010-9348-7.

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15

Milyutin, A. V., N. V. Safonova, V. P. Chesnokov та ін. "Synthesis, properties, and biological activity of β-aroylpyruvoyl hydrazides oF N-methyl- and N-phenylanthranilic acid". Pharmaceutical Chemistry Journal 30, № 5 (1996): 310–12. http://dx.doi.org/10.1007/bf02333968.

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16

Girisha, Hanakere R., Gejjalagere R. Srinivasa, and D. Channe Gowda. "A simple and environmentally friendly method for the synthesis of N-phenylanthranilic acid derivatives." Journal of Chemical Research 2006, no. 5 (2006): 342–44. http://dx.doi.org/10.3184/030823406777411098.

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17

Xiao, Shangyou, Guang Xu, Gang Chen, et al. "Intramolecular cyclization of N-phenylanthranilic acid catalyzed by MCM-41 with different pore diameters." Research on Chemical Intermediates 41, no. 12 (2015): 10125–35. http://dx.doi.org/10.1007/s11164-015-2017-2.

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18

Ruwart, M. J., N. M. Nichols, B. D. Rush, R. Mochizuki, G. Elliott, and M. N. Brunden. "16,16-dimethyl PGE2 partially prevents N-phenylanthranilic acid-induced kidney damage in the rat." Prostaglandins, Leukotrienes and Medicine 20, no. 2 (1985): 139–40. http://dx.doi.org/10.1016/0262-1746(85)90004-6.

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19

Sim, Sophie A., Graham C. Saunders, Joseph R. Lane, and William Henderson. "Synthesis and characterisation of organo-platinum(II) complexes of the N,O-donor ligands hippuric acid (N-benzoylglycine) and N-phenylanthranilic acid." Inorganica Chimica Acta 450 (August 2016): 285–92. http://dx.doi.org/10.1016/j.ica.2016.05.053.

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20

Whittingham, Alan, Ligia Delacruz, Neil J. Gregg, Amulfo Albores, Patricia Ijomah, and Peter H. Bach. "The Kinetics of Papillotoxic Doses of ³H-N-Phenylanthranilic Acid in Rats." Kidney and Blood Pressure Research 12, no. 5-6 (1989): 406–12. http://dx.doi.org/10.1159/000173219.

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21

ZAPALA, L., and J. KALEMBKIEWICZ. "Studies on the distribution of N-phenylanthranilic acid in two-phase system: Aromatic solvent–water." Talanta 69, no. 3 (2006): 601–7. http://dx.doi.org/10.1016/j.talanta.2005.10.030.

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22

Kasprzycka, Ewa, Israel P. Assunção, Michael Bredol, Marina Lezhnina, and Ulrich H. Kynast. "Preparation, characterization and optical properties of rare earth complexes with derivatives of N-phenylanthranilic acid." Journal of Luminescence 232 (April 2021): 117818. http://dx.doi.org/10.1016/j.jlumin.2020.117818.

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23

GAIDUKEVICH, A. N., E. N. SVECHNIKOVA, E. E. MIKITENKO, T. A. KOSTINA, and M. BARAKA. "ChemInform Abstract: Reaction Behavior of Phenylanthranilic Acid. Part 5. Investigation of Correlating Dependency on Physicochemical Properties and Biological Activity in Series of 4-Chloro-5-nitro-N-phenylanthranilic Acid Derivatives." ChemInform 25, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199437079.

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24

Isaev, S. G., O. M. Sviechnikova, A. O. Devyatkina, T. A. Kostina, and T. N. Svyatska. "Reactivity of phenylanthranilic acids derivatives. Xxiii. Synthesis and acid-base properties of 4,5-dymethoxy-n-(2´-carboxyphenyl)anthranilic acids." Journal of Organic and Pharmaceutical Chemistry 11, no. 3(43) (2013): 26–31. http://dx.doi.org/10.24959/ophcj.13.748.

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25

Ozkan, Sveta Zhiraslanovna, Aleksandr Ivanovich Kostev, Petr Aleksandrovich Chernavskii, and Galina Petrovna Karpacheva. "Novel Hybrid Nanomaterials Based on Poly-N-Phenylanthranilic Acid and Magnetic Nanoparticles with Enhanced Saturation Magnetization." Polymers 14, no. 14 (2022): 2935. http://dx.doi.org/10.3390/polym14142935.

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A one-step preparation method for cobalt- and iron-containing nanomaterials based on poly-N-phenylanthranilic acid (P-N-PAA) and magnetic nanoparticles (MNP) was developed for the first time. To synthesize the MNP/P-N-PAA nanocomposites, the precursor is obtained by dissolving a Co (II) salt in a magnetic fluid based on Fe3O4/P-N-PAA with a core-shell structure. During IR heating of the precursor in an inert atmosphere at T = 700–800 °C, cobalt interacts with Fe3O4 reduction products, which results in the formation of a mixture of spherical Co-Fe, γ-Fe, β-Co and Fe3C nanoparticles of various s

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26

Docampo Palacios, Maite L., and Rolando F. Pellón Comdom. "Synthesis of N-Phenylanthranilic Acid Derivatives Using Water as Solvent in the Presence of Ultrasound Irradiation." Synthetic Communications 33, no. 10 (2003): 1771–75. http://dx.doi.org/10.1081/scc-120018938.

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27

Ozkan, Sveta Zhiraslanovna, Aleksandr Ivanovich Kostev, Galina Petrovna Karpacheva, Petr Aleksandrovich Chernavskii, Andrey Aleksandrovich Vasilev, and Dmitriy Gennad’evich Muratov. "Hybrid Electromagnetic Nanomaterials Based on Polydiphenylamine-2-carboxylic Acid." Polymers 12, no. 7 (2020): 1568. http://dx.doi.org/10.3390/polym12071568.

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Hybrid ternary nanomaterials based on conjugated polymer polydiphenylamine-2-carboxylic acid (PDPAC) (poly-N-phenylanthranilic acid), Fe3O4 nanoparticles and single-walled carbon nanotubes (SWCNT) were prepared for the first time. Polymer–metal–carbon Fe3O4/SWCNT/PDPAC nanocomposites were synthesized via in situ oxidative polymerization of diphenylamine-2-carboxylic acid (DPAC) by two different ways: in an acidic medium and in the interfacial process in an alkaline medium. In an alkaline medium (pH 11.4), the entire process of Fe3O4/SWCNT/PDPAC-1 synthesis was carried out in one reaction vesse

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28

Tatematsu, Yohei, Hiroki Hayashi, Ryo Taguchi, Haruhi Fujita, Atsushi Yamamoto, and Kazuto Ohkura. "Effect of N-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition." Biological & Pharmaceutical Bulletin 39, no. 2 (2016): 278–84. http://dx.doi.org/10.1248/bpb.b15-00717.

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29

Rashidi Nassab, H., A. Souri, A. Javadian, and M. K. Amini. "A novel mercury-free stripping voltammetric sensor for uranium based on electropolymerized N-phenylanthranilic acid film electrode." Sensors and Actuators B: Chemical 215 (August 2015): 360–67. http://dx.doi.org/10.1016/j.snb.2015.03.086.

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30

Syugaev, A. V., K. A. Yazovskikh, A. A. Shakov, S. F. Lomayeva, and A. N. Maratkanova. "Molecular transformations in interfaces and liquid media under wet ball milling of iron with N-phenylanthranilic acid." Colloids and Surfaces A: Physicochemical and Engineering Aspects 608 (January 2021): 125620. http://dx.doi.org/10.1016/j.colsurfa.2020.125620.

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31

de la Peña, A. Muñoz, A. Espinosa Mansilla, N. Mora Díez, D. Bohoyo Gil, A. C. Olivieri, and G. M. Escandar. "Second-Order Calibration of Excitation—Emission Matrix Fluorescence Spectra for the Determination of N-Phenylanthranilic Acid Derivatives." Applied Spectroscopy 60, no. 3 (2006): 330–38. http://dx.doi.org/10.1366/000370206776342643.

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32

Betton, Graham R., Daniela Ennulat, David Hoffman, Jean-Charles Gautier, Ernie Harpur, and Syril Pettit. "Biomarkers of Collecting Duct Injury in Han-Wistar and Sprague-Dawley Rats Treated with N-Phenylanthranilic Acid." Toxicologic Pathology 40, no. 4 (2012): 682–94. http://dx.doi.org/10.1177/0192623311436174.

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33

STOYANOVA, Angelina M. "Spectrophotometric Determination of Trace Iron by Using Its Catalytic Effect on the N-Phenylanthranilic Acid-Potassium Periodate Reaction." Analytical Sciences 24, no. 5 (2008): 595–99. http://dx.doi.org/10.2116/analsci.24.595.

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34

Yao, Ganbing, Zhihui Li, Zhanxiang Xia, and Qingcang Yao. "Solubility of N-phenylanthranilic acid in nine organic solvents from T= (283.15 to 318.15) K: Determination and modelling." Journal of Chemical Thermodynamics 103 (December 2016): 218–27. http://dx.doi.org/10.1016/j.jct.2016.08.017.

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35

Hughes, B. A., and Y. Segawa. "cAMP‐activated chloride currents in amphibian retinal pigment epithelial cells." Journal of Physiology 466, no. 1 (1993): 749–66. http://dx.doi.org/10.1113/jphysiol.1993.sp019743.

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1. The effect of cAMP on whole‐cell currents in isolated retinal pigment epithelial (RPE) cells of the bullfrog and marine toad was investigated by means of the perforated patch clamp technique. 2. Superfusing cells with either cAMP or forskolin led to the development of a time‐independent current that had a linear current‐voltage (I‐V) relationship. The reversal potential of (Vrev) of the cAMP‐activated current was unaffected by the removal of either Na+ or HCO3‐ from the external and internal solutions or by the addition of extracellular barium, but it was near the Cl‐ equilibrium potential

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36

Singh, M., M. Krouse, S. Moon, and J. J. Wine. "Most basal I(SC) in Calu-3 human airway cells is bicarbonate-dependent Cl- secretion." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 4 (1997): L690—L698. http://dx.doi.org/10.1152/ajplung.1997.272.4.l690.

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Serous cells secrete antibiotic-rich fluid, but secretion is impaired in cystic fibrosis. We are investigating Calu-3 cells as a serous cell model. Basal short-circuit current (I[SC]) in Calu-3 cells grown at air interface had a basal I(SC) approximately six times larger than submerged cultures (69 +/- 22 vs. 11 +/- 10 microA/cm2). Basal I(SC) in either condition was reduced only 7 +/- 5% by bumetanide and was unaffected by apical amiloride, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS), or calixarene but was reduced 77 +/- 18% by N-phenylan

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37

Molleman, A., L. WC Liu, and J. D. Huizinga. "Muscarinic activation of transient inward current and contraction in canine colon circular smooth muscle cells." Canadian Journal of Physiology and Pharmacology 79, no. 1 (2001): 34–42. http://dx.doi.org/10.1139/y00-105.

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Muscarinic receptor mediated membrane currents and contractions were studied in isolated canine colon circular smooth muscle cells. Carbachol (105M) evoked a slow transient inward current that was superimposed by a transient outward current at holding potentials greater than 50 mV. Carbachol contracted the cells by 70 ± 2%. The effects of carbachol were blocked by atropine (106M), tetraethyl ammonium (20 mM), and BAPTA-AM (25 mM applied for 20 min). The inward current and contraction were not sensitive to diltiazem (105M), nitrendipine (3 × 107M), niflumic acid (105M), or N-phenylanthran

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38

Sun, Jiaying, Shaojing Liu, Lingli Han, and Tao Liu. "Distinct roles of Ag(I) and Cu(II) as cocatalysts in the intramolecular cyclization of N-methyl-N-phenylanthranilic acid: A theoretical investigation." Molecular Catalysis 509 (June 2021): 111634. http://dx.doi.org/10.1016/j.mcat.2021.111634.

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39

Betton, Graham R., Kerstin Kenne, Rebecca Somers, and Andrew Marr. "Protein biomarkers of nephrotoxicity; a review and findings with cyclosporin A, a signal transduction kinase inhibitor and N-phenylanthranilic acid." Cancer Biomarkers 1, no. 1 (2005): 59–67. http://dx.doi.org/10.3233/cbm-2005-1107.

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40

al-Nakkash, L., and C. U. Cotton. "Bovine pancreatic duct cells express cAMP- and Ca(2+)-activated apical membrane Cl- conductances." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 1 (1997): G204—G216. http://dx.doi.org/10.1152/ajpgi.1997.273.1.g204.

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Secretion of salt and water by the epithelial cells that line pancreatic ducts depends on activation of apical membrane Cl- conductance. In the present study, we characterized two types of Cl- conductances present in the apical cell membrane of bovine pancreatic duct epithelial cells. Primary cultures of bovine main pancreatic duct epithelium and an immortalized cell line (BPD1) derived from primary cultures were used. Elevation of intracellular adenosine 3',5'-cyclic monophosphate (cAMP) or Ca2+ in intact monolayers of duct epithelium induced sustained anion secretion. Agonist-induced changes

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41

Cooke, H. J., Y. Z. Wang, R. Reddix, and N. Javed. "Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 268, no. 3 (1995): G465—G470. http://dx.doi.org/10.1152/ajpgi.1995.268.3.g465.

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Previous studies demonstrated neurally mediated recurrent increases in short-circuit current (Isc) suggestive of anion secretion in guinea pig distal colon. To determine the neural pathways involved, segments of distal colon from guinea pigs were mounted in flux chambers. In muscle-stripped or whole thickness preparations, serosal addition of the histamine H2 receptor agonist, dimaprit, caused cyclical increases in Isc, which were reduced by the chloride channel blocker, N-phenylanthranilic acid, but not by the sodium channel blocker amiloride. Dimaprit stimulated release of [3H]acetylcholine

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42

Jung, F., S. Selvaraj, and J. J. Gargus. "Blockers of platelet-derived growth factor-activated nonselective cation channel inhibit cell proliferation." American Journal of Physiology-Cell Physiology 262, no. 6 (1992): C1464—C1470. http://dx.doi.org/10.1152/ajpcell.1992.262.6.c1464.

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In serum-deprived G(o)-arrested cells, the addition of serum or growth factors initiates a cascade of events that culminates in DNA synthesis and mitosis. Recently, we showed that in mouse L-M(TK-) fibroblasts a 28-pS nonselective cation channel (NS channel) becomes quiescent at G(o) arrest and rapidly active within seconds of platelet-derived growth factor (PDGF) or serum addition, placing this response very early in the postreceptor signaling cascade. However, lack of specific channel blockers hindered determination of whether channel activation was necessary for mitogenesis. Derivatives of

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43

Fan, Shih-Fang, and Stephen Yazulla. "Electrogenic Hyperpolarization-Elicited Chloride Transporter Current in Blue Cones of Zebrafish Retinal Slices." Journal of Neurophysiology 77, no. 3 (1997): 1447–59. http://dx.doi.org/10.1152/jn.1997.77.3.1447.

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Fan, Shih-Fang and Stephen Yazulla. Electrogenic hyperpolarization-elicited chloride transporter current in blue cones of zebrafish retinal slices. J. Neurophysiol. 77: 1447–1459, 1997. Voltage-activated currents in blue cones of the retinal slice of zebrafish were characterized using whole cell recording techniques. Depolarizing-elicited currents were recorded: an outward tetraethylammonium (TEA)-sensitive K+ current ( I Kx), an outward Ca2+-activated Cl− current ( I Cl(Ca)), from which we inferred an inward Ca2+ current ( I Ca) as well as a hyperpolarizing-elicited nonselective inward cation

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44

Luo, Jiaqi, Yingchen Wang, Chuncheng Shi, Fan Zhang, and Qiushuo Yu. "Solubility and thermodynamic properties of N-phenylanthranilic acid in Water + Methanol/Ethanol/tert-butanol binary solvents from 283.15 K to 323.15 K." Journal of Chemical Thermodynamics 168 (May 2022): 106748. http://dx.doi.org/10.1016/j.jct.2022.106748.

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45

Mbani O., Armel L., Evan F. Bonnand, Awawou G. Paboudam, et al. "Synthesis, structural analysis, and docking studies with SARS-CoV-2 of a trinuclear zinc complex with N-phenylanthranilic acid ligands." Acta Crystallographica Section C Structural Chemistry 78, no. 4 (2022): 231–39. http://dx.doi.org/10.1107/s205322962200239x.

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The structure of a trinuclear zinc complex, hexakis(μ2-2-anilinobenzoato)diaquatrizinc(II), [Zn2(C13H10NO2)6(H2O)2] or (NPA)6Zn3(H2O)2 (NPA is 2-anilinobenzoate or N-phenylanthranilate), is reported. The complex crystallizes in the triclinic space group P-1 and the central ZnII atom is located on an inversion center. The NPA ligand is found to coordinate via the carboxylate O atoms with unique C—O bond lengths that support an unequal distribution of resonance over the carboxylate fragment. The axial H2O ligands form hydrogen bonds with neighboring molecules that stabilize the supramolecular sy

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46

Kumaresan, S., P. G. Seethalakshmi, P. Kumaradhas, and B. Devipriya. "Synthesis and structural characterization of organic co-crystals 4,4′-bipyridine-bis(N-phenylanthranilic acid) and 4,4′-bipyridinium bis(3-carboxypyridine-2-carboxylate)." Journal of Molecular Structure 1032 (January 2013): 169–75. http://dx.doi.org/10.1016/j.molstruc.2012.08.008.

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47

Price, Sally A., Dai Davies, Rachel Rowlinson, et al. "Characterization of Renal Papillary Antigen 1 (RPA-1), a Biomarker of Renal Papillary Necrosis." Toxicologic Pathology 38, no. 3 (2010): 346–58. http://dx.doi.org/10.1177/0192623310362246.

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Renal papillary necrosis (RPN) is a relatively common toxicity observed in preclinical drug safety testing. It is also observed in a variety of human diseases. RPN is difficult to diagnose without expensive scanning methods or histopathology. A noninvasive biomarker that could be detected at early stages of kidney damage would be of great value both to preclinical drug safety testing and in the clinic. An antibody raised to an unknown epitope of an antigen in rat kidney papilla was found to be specific for collecting duct cells in the kidney; this was termed renal papillary antigen 1 (RPA-1).

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48

Fischer, Horst, Beate Illek, Walter E. Finkbeiner, and Jonathan H. Widdicombe. "Basolateral Cl channels in primary airway epithelial cultures." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 6 (2007): L1432—L1443. http://dx.doi.org/10.1152/ajplung.00032.2007.

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Salt and water absorption and secretion across the airway epithelium are important for maintaining the thin film of liquid lining the surface of the airway epithelium. Movement of Cl across the apical membrane involves the CFTR Cl channel; however, conductive pathways for Cl movement across the basolateral membrane have been little studied. Here, we determined the regulation and single-channel properties of the Cl conductance ( GCl) in airway surface epithelia using epithelial cultures from human or bovine trachea and freshly isolated ciliated cells from the human nasal epithelium. In Ussing c

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Illek, B., J. R. Yankaskas, and T. E. Machen. "cAMP and genistein stimulate HCO3- conductance through CFTR in human airway epithelia." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 4 (1997): L752—L761. http://dx.doi.org/10.1152/ajplung.1997.272.4.l752.

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We studied the role of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel as an HCO3- conductor during adenosine 3',5'-cyclic monophosphate (cAMP)-dependent regulation in human airway epithelial cell lines. HCO3- or Cl- currents across the apical membrane were measured in the presence of an HCO3- or Cl- gradient under short-circuit conditions in intact and alpha-toxin-permeabilized monolayers, which allowed manipulation of the intracellular regulators cAMP and ATP. CFTR as the current carrier for HCO3- was identified by 1) stimulation by cAMP, 2) ATP dependence, 3) bloc

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Berger, Jens, Katrin Richter, Wolfgang G. Clauss, and Martin Fronius. "Evidence for basolateral Cl− channels as modulators of apical Cl− secretion in pulmonary epithelia of Xenopus laevis." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 3 (2011): R616—R623. http://dx.doi.org/10.1152/ajpregu.00464.2010.

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Abstract:

Pulmonary epithelia of air-breathing vertebrates are covered by a thin, fluid layer that is essential for immune defense and gas diffusion. The composition of this layer is maintained by ion transport mechanisms, including Cl− transport. The present study focuses on the function of basolateral Cl− channels in Xenopus pulmonary epithelia, since knowledge concerning this issue is limited. Therefore, Ussing chamber measurements were performed, and transepithelial short-circuit currents ( ISC) were monitored. Basolateral application of the Cl− channel inhibitor N-phenylanthranilic acid (DPC) resul

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