Relevant bibliographies by topics / Nanoparticles, brain delivery, natural conpounds

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Academic literature on the topic 'Nanoparticles, brain delivery, natural conpounds'

Author: Grafiati
Published: 10 March 2023

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Journal articles on the topic "Nanoparticles, brain delivery, natural conpounds"

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Liang, Jianming, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu, and Jianxin Wang. "Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery." ACS Applied Materials & Interfaces 10, no. 36 (August 16, 2018): 30201–13. http://dx.doi.org/10.1021/acsami.8b11782.

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O. Elzoghby, Ahmed, Mahmoud M. Abd-Elwakil, Kholod Abd-Elsalam, Mustafa T. Elsayed, Yosra Hashem, and Ola Mohamed. "Natural Polymeric Nanoparticles for Brain-Targeting: Implications on Drug and Gene Delivery." Current Pharmaceutical Design 22, no. 22 (May 31, 2016): 3305–23. http://dx.doi.org/10.2174/1381612822666160204120829.

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Han, Lei, Anling Zhang, Hanjie Wang, Peiyu Pu, Chunsheng Kang, and Jin Chang. "Construction of novel brain-targeting gene delivery system by natural magnetic nanoparticles." Journal of Applied Polymer Science 121, no. 6 (April 12, 2011): 3446–54. http://dx.doi.org/10.1002/app.33995.

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Perteghella, Sara, Giovanna Rassu, Elisabetta Gavini, Antonella Obinu, Elia Bari, Delia Mandracchia, Maria Cristina Bonferoni, Paolo Giunchedi, and Maria Luisa Torre. "Crocetin as New Cross-Linker for Bioactive Sericin Nanoparticles." Pharmaceutics 13, no. 5 (May 9, 2021): 680. http://dx.doi.org/10.3390/pharmaceutics13050680.

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The nose-to-brain delivery route is used to bypass the blood–brain barrier and deliver drugs directly into the brain. Over the years, significant signs of progress have been made in developing nano-drug delivery systems to address the very low drug transfer levels seen with conventional formulations (e.g., nasal solutions). In this paper, sericin nanoparticles were prepared using crocetin as a new bioactive natural cross-linker (NPc) and compared to sericin nanoparticles prepared with glutaraldehyde (NPg). The mean diameter of NPc and NPg was about 248 and 225 nm, respectively, and suitable for nose-to-brain delivery. The morphological investigation revealed that NPc are spherical-like particles with a smooth surface, whereas NPg seem small and rough. NPc remained stable at 4 °C for 28 days, and when freeze-dried with 0.1% w/v of trehalose, the aggregation was prevented. The use of crocetin as a natural cross-linker significantly improved the in vitro ROS-scavenging ability of NPc with respect to NPg. Both formulations were cytocompatible at all the concentrations tested on human fibroblasts and Caco-2 cells and protected them against oxidative stress damage. In detail, for NPc, the concentration of 400 µg/mL resulted in the most promising to maintain the cell metabolic activity of fibroblasts higher than 90%. Overall, the results reported in this paper support the employment of NPc as a nose-to-brain drug delivery system, as the brain targeting of antioxidants is a potential tool for the therapy of neurological diseases.
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Neha, Bhatt, Bhatt Ganesh, and Kothiyal Preeti. "Drug Delivery to The Brain Using Polymeric Nanoparticles: A Review." International Journal of Pharmaceutical and Life Sciences 2, no. 3 (June 24, 2013): 107–32. http://dx.doi.org/10.3329/ijpls.v2i3.15457.

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Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50–300 nm generally). The use of minute particles as drug carriers for targeted treatment has been studied over a long period of time. A selective accumulation of active substances in target tissues has been demonstrated for certain so-called nanocarrier systems that are administered bound to pharmaceutical drugs. Great expectations are placed on nanocarrier systems that can overcome natural barriers such as the blood-brain barrier (BBB) and transport the medication directly to the desired tissue and thus heal neurological diseases that were formerly incurable. Polymeric Nanoparticle have been shown to be promising carriers for CNS drug delivery due to their potential both in encapsulating drugs, hence protecting them from excretion and metabolism, and in delivering active agents across the blood – brain barrier without inflicting any damage to the barrier. Different polymers have been used and different strategies like surface modification have been done to increase the retention time of nanoparticles. DOI: http://dx.doi.org/10.3329/ijpls.v2i3.15457 International Journal of Pharmaceutical and Life Sciences Vol.2(3) 2013: 107-132
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Ansari, Mohammad A., Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad N. Alomary, Muthu Thiruvengadam, Faheem H. Pottoo, and Niyaz Ahmad. "Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review." Current Pharmaceutical Design 26, no. 11 (April 24, 2020): 1128–37. http://dx.doi.org/10.2174/1381612826666200116153912.

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: Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease, Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted, drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in this review.
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Pepe, Giuseppe, Enrica Calce, Valentina Verdoliva, Michele Saviano, Vittorio Maglione, Alba Di Pardo, and Stefania De Luca. "Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders." International Journal of Molecular Sciences 21, no. 22 (November 23, 2020): 8846. http://dx.doi.org/10.3390/ijms21228846.

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Identification of molecules able to promote neuroprotective mechanisms can represent a promising therapeutic approach to neurodegenerative disorders including Huntington’s disease. Curcumin is an antioxidant and neuroprotective agent, even though its efficacy is limited by its poor absorption, rapid metabolism, systemic elimination, and limited blood–brain barrier (BBB) permeability. Herein, we report on novel biodegradable curcumin-containing nanoparticles to favor the compound delivery and potentially enhance its brain bioavailability. The prepared hyaluronan-based materials able to self-assemble in stable spherical nanoparticles, consist of natural fatty acids chemically conjugated to the natural polysaccharide. The aim of this study is to provide a possible effective delivery system for curcumin with the expectation that, after having released the drug at the specific site, the biopolymer can degrade to nontoxic fragments before renal excretion, since all the starting materials are provided by natural resource. Our findings demonstrate that curcumin-encapsulated nanoparticles enter the cells and reduce their susceptibility to apoptosis in an in vitro model of Huntington’s disease.
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Habib, Saffiya, and Moganavelli Singh. "Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review." Polymers 14, no. 4 (February 12, 2022): 712. http://dx.doi.org/10.3390/polym14040712.

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Nanotechnology has opened up a world of possibilities for the treatment of brain disorders. Nanosystems can be designed to encapsulate, carry, and deliver a variety of therapeutic agents, including drugs and nucleic acids. Nanoparticles may also be formulated to contain photosensitizers or, on their own, serve as photothermal conversion agents for phototherapy. Furthermore, nano-delivery agents can enhance the efficacy of contrast agents for improved brain imaging and diagnostics. However, effective nano-delivery to the brain is seriously hampered by the formidable blood–brain barrier (BBB). Advances in understanding natural transport routes across the BBB have led to receptor-mediated transcytosis being exploited as a possible means of nanoparticle uptake. In this regard, the oligopeptide Angiopep-2, which has high BBB transcytosis capacity, has been utilized as a targeting ligand. Various organic and inorganic nanostructures have been functionalized with Angiopep-2 to direct therapeutic and diagnostic agents to the brain. Not only have these shown great promise in the treatment and diagnosis of brain cancer but they have also been investigated for the treatment of brain injury, stroke, epilepsy, Parkinson’s disease, and Alzheimer’s disease. This review focuses on studies conducted from 2010 to 2021 with Angiopep-2-modified nanoparticles aimed at the treatment and diagnosis of brain disorders.
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Aderibigbe, Blessing Atim, and Tobeka Naki. "Chitosan-Based Nanocarriers for Nose to Brain Delivery." Applied Sciences 9, no. 11 (May 30, 2019): 2219. http://dx.doi.org/10.3390/app9112219.

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In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.
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Bakrim, Saad, Sara Aboulaghras, Naoual El Menyiy, Nasreddine El Omari, Hamza Assaggaf, Learn-Han Lee, Domenico Montesano, et al. "Phytochemical Compounds and Nanoparticles as Phytochemical Delivery Systems for Alzheimer’s Disease Management." Molecules 27, no. 24 (December 19, 2022): 9043. http://dx.doi.org/10.3390/molecules27249043.

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Alzheimer’s disease remains one of the most widespread neurodegenerative reasons for dementia worldwide and is associated with considerable mortality and morbidity. Therefore, it has been considered a priority for research. Indeed, several risk factors are involved in the complexity of the therapeutic ways of this pathology, including age, traumatic brain injury, genetics, exposure to aluminum, infections, diabetes, vascular diseases, hypertension, dyslipidemia, and obesity. The pathophysiology of Alzheimer’s disease is mostly associated with hyperphosphorylated protein in the neuronal cytoplasm and extracellular plaques of the insoluble β-amyloid peptide. Therefore, the management of this pathology needs the screening of drugs targeting different pathological levels, such as acetylcholinesterase (AchE), amyloid β formation, and lipoxygenase inhibitors. Among the pharmacological strategies used for the management of Alzheimer’s disease, natural drugs are considered a promising therapeutic strategy. Indeed, bioactive compounds isolated from different natural sources exhibit important anti-Alzheimer effects by their effectiveness in promoting neuroplasticity and protecting against neurodegeneration as well as neuroinflammation and oxidative stress in the brain. These effects involve different sub-cellular, cellular, and/or molecular mechanisms, such as the inhibition of acetylcholinesterase (AchE), the modulation of signaling pathways, and the inhibition of oxidative stress. Moreover, some nanoparticles were recently used as phytochemical delivery systems to improve the effects of phytochemical compounds against Alzheimer’s disease. Therefore, the present work aims to provide a comprehensive overview of the key advances concerning nano-drug delivery applications of phytochemicals for Alzheimer’s disease management.
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Dissertations / Theses on the topic "Nanoparticles, brain delivery, natural conpounds"

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GUCCIONE, CLIZIA. "Design, optimization, characterization and performance of nanocarriers for brain delivery of natural compounds." Doctoral thesis, 2016. http://hdl.handle.net/2158/1036415.

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The aim of my PhD project was the design, optimization, characterisation and performance of nanocarriers for brain delivery loaded with natural compounds. Blood brain barrier (BBB) represents an important physio-chemical obstacle for the delivery of therapeutics into the brain and the limitations of conventional therapies increase the interest regard the use of nanotechnologies for neurodegenerative treatments. Several natural products have been studied for the prevention and the treatment of brain diseases, frequently, with very interesting therapeutic effects but their poor solubility, bioavailability and BBB permeability have limited their use. To overcome these problematical aspects, different NPs that target and reach brain tissues were formulated and examined during this PhD thesis. My investigation started from the analysis of BBB in order to establish formulative strategies. Two different endogenous mechanisms of transport across the BBB, and deliver therapeutics into the brain, were selected: receptor mediated endocytosis by Apo-lipoprotein E (Apo-E) and adsorptive transcytosis by plasmatic proteins. One synthetic unit, ethyl-cyanoacrylate, and a protein, human serum albumin, were selected as materials for the design of brain delivery systems. In case of albumin nanoparticle, two distinctive method of preparations were investigated in order to reduce the use of toxic agents in the formulation, according with green chemistry criteria. Nanocarriers were developed and fully characterized in term of size, superficial charge, encapsulation efficiency, loading capacity and morphology, using Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM). The brain uptake of fluorescent NPs, their biodistribution and cellular-functional effects were evaluated in vivo in healthy rats, after intracerebral injection, while the ability of developed nanocarriers to cross BBB, after intraperitoneal and intravenous administration, were assessed. Behavioural studies were performed for the investigation of safety profile. After the results obtained from the in vivo examinations, Salvianolic acid B (SalB) isolated from Salvia miltiorrhiza Bge. and Andrographolide (AG) from Andrographis paniculata’s leaves were selected, for their pharmacological profile, to be loaded in developed NPs for the treatment of neurodegenerative disease. XX The permeability across the BBB of AG in the free form and loaded in nanocarriers was evaluated using a well established in vitro BBB model based on monolayers of human immortalized endothelial cells hCMEC / D3, that expresses the receptors for Apo-E (LRP-1expression).
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Gomes, Maria João Bidarra Tavares. "Modulation of drug efflux at the blood-brain barrier through targeted siRNA delivery via nanoparticles." Doctoral thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/103385.

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Gomes, Maria João Bidarra Tavares. "Modulation of drug efflux at the blood-brain barrier through targeted siRNA delivery via nanoparticles." Tese, 2017. https://repositorio-aberto.up.pt/handle/10216/103385.

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