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Dissertations / Theses on the topic 'Naphthyridin'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Bode, Matthias. "Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979241499.

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2

Wiik, Jhonny. "Naphthyridine Based Molecular Switches." Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-15477.

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This thesis is focused on the synthesis and halogenation of 1,5-naphthyridine and 2,6-naphthyridine with the aim of finding a suitable method to synthesize mono- and bis-naphthyridine centered tridentate ligands for ruthenium complexes. Firstly the halogenated naphthyridines were synthesized, then 2-(2-thienyl)-6-ributylstannylpyridine was synthesized, and the two building blocks were coupled through a Stille cross coupling reaction. The thesis describes the synthesis of 2,6-dichloro-1,5-naphthyridine, 2-chloro-1,5-naphthyridine, 1,5-dichloro-2,6-naphthyridine and 1-chloro-2,6-naphthyridine. T

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3

Wormell, Paul. "The electronic spectra of some naphthyridines." Thesis, The University of Sydney, 1985. https://hdl.handle.net/2123/26866.

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This thesis reports and interprets the electronic spectra of two aromatic heterocyclic molecules: 1,8- naphthyridine and 2,7—naphthyridine. This completes the first detailed survey of the spectra of the ten naphthyridine isomers. The naphthyridines are analogues of naphthalene, and contain two nitrogen atoms in a variety of substitution pattern.

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4

Bailey, Andrew James. "An exploration of the solid-state architectures formed by 1,8-naphthyridine-2,7-dicarbonyl derivatives." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/179457/.

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Building on previous studies of tape formation by dicarbonyl substituted pyridine derivatives in the solid state, it was proposed that expansion of the hydrogen bonding array from three donor-acceptor pairs to four should increase the strength of the hydrogen-bonded array. Accordingly an investigation into the 1,8-naphthyridine-2,7-dicarbonyl derivatives has now been undertaken. Following the synthesis of 1,8-naphthyridine-2,7-dicarboxylic acid, during which the solid-state structures of three key intermediates were obtained, thirty-five novel 1,8-naphthyridine-2,7-dicarboxylates and fourteen

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5

Devaux, Floriane. "Synthesis and AFM-based single-molecule force spectroscopy of helical aromatic oligoamide foldamers." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0346.

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Les foldamères sont des architectures moléculaires synthétiques repliées, inspirées par les structures et les fonctions des biopolymères naturels. Le repliement est un processus sélectionné par la nature pour contrôler la conformation de sa machinerie moléculaire afin de réaliser des tâches chimiques ou mécaniques. Durant les dix dernières années de recherche sur les foldamères, des oligomères synthétiques, capables d'adopter des conformations repliées bien définies et prévisibles, comme des hélices, ont été proposés. Les progrès récents ont montré que la synthèse chimique par étapes et le des

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6

尹俊偉 and Chun-wai Wan. "Spectroscopic properties and coordination chemistry of d10 metal complexes with the polypyridyl and naphthyridyl ligands." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223564.

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Wan, Chun-wai. "Spectroscopic properties and coordination chemistry of d10 metal complexes with the polypyridyl and naphthyridyl ligands /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22227301.

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8

Buttard, Floris. "3-Vinyl-1,2,4-triazines comme plateformes bifonctionnelles pour la synthèse de nouvelles structures tétrahydro-[1,6]-naphthyridines." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2032.

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Le développement de nouvelles méthodes de synthèse de molécules hétérocycliques originales représente un enjeu actuel majeur en chimie organique. L’objectif est de fournir de nouveaux outils chimiques pour le développement de molécules actives en chimie médicinale et/ou pour l’étude de la biologie chimique, tout en contribuant à l’exploration de l’espace chimique.Dans ce contexte, le travail effectué au cours de cette thèse de doctorat a visé à élaborer de nouvelles voies de synthèse de motifs tétrahydro-[1,6]-naphtyridines. La pierre angulaire des méthodologies développées réside dans l’utili

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9

Harris, Cragin K. "Synthesis and Characterization of Five New Tetrakis(N-phenylacetamidato) Dirhodium(II) Amine Complexes and One Molybdenum Cofactor Described Crystallographically." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2525.

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Six new crystal structures were determined using a Rigaku Mercurcy 375/MCCD(XtaLab mini) diffractometer. The structure of a molybdenum cofactor was solved resulting in an R1 (R1 = Σ ||Fo| - |Fc|| / Σ |Fo|) of 3.61% despite the presence of a disordered DMSO molecule. New Tetrakis(N-phenylacetamidato) Dirhodium(II) complexes were synthesized and characterized. Two 2,2-cis-[Rh2(NPhCOCH3)4]•(C3H4N2)x where x= 1 or 2 were successfully crystallized and solved with R1 values below 5%. Additional studies were conducted via NMR to observe formation of both products. Three potential catalysts were synth

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10

Ye, Guozhong. "Synthesis and reactions of cyclic ketene-N,N-acetals." Diss., Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-09142008-210135.

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11

Mefetah, Hafid. "Benzo(b)-1,8-naphthyridine-5-one : synthese et activite antiparasitaire de nouveaux derives n-alkyles : synthese et caracterisation de tetracycles derives de la molecule-titre." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22956.

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12

Misbahi, Houriya. "Synthèse de nouveaux dérivés de la benzo[b]-1,8-naphthyridine-5-one : étude de l'activité de réversion de la résistance aux anticancéreux et à la chloroquine." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22952.

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13

Fernandez, Sarah [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Chromium- and cobalt-catalyzed cross-coupling and amination reactions and synthesis and reactivity of Pyrido[3,2-f][1,7]naphthyridines / Sarah Fernandez. Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1104128934/34.

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14

Chan, Wing-han, and 陳詠嫻. "Coordination chemistry of the pyridyl, naphthyridyl and [alpha], [omega]-polyether phosphine ligands and x-ray crystal structures andspectroscopic properties of the metal complex derivatives." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31236595.

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15

Chan, Wing-han. "Coordination chemistry of the pyridyl, naphthyridyl and [alpha], [omega]-polyether phosphine ligands and x-ray crystal structures and spectroscopic properties of the metal complex derivatives /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19481640.

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16

Calcul, Laurent. "Etude chimique et biologique des éponges marines Podospongia aff. Loveni, Siphonochalina sp. Et Xestospongia sp. : Isolement-bioactivité-approche de synthèse d'alcaloïdes de type benzo[de][1,6]naphthyridine isolés de Xestospongia sp." Paris, Muséum national d'histoire naturelle, 2005. http://www.theses.fr/2005MNHN0035.

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The work described in the manuscrit deals with the isolation and the synthesis of bioactive molecules from marine sponges. The sponges Podospongia aff. Loveni, Siphonochalina sp. And Xestospongia sp. Were selected for chemical study due to their antifungical, anti-inflammatory and/ or antibacterial activities. The elucidation of the structures of these molecules was carried out thanks to spectral analysis such as mass spectrometry, 1H and 13C NMR using 2D's methods (HMQC, HMBC, COSY and NOESY). A new sterol with unsaturated side chain, the 24-oxo-nor-1922-cholestanol was isolated from the Pod

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17

Greiner, Robert [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Regioselective organometallic functionalization of 1,5- and 2,7-Naphthyridines & preparation of new fluorescent aryl naphthalene dicarboximides with large stokes shifts and strong solvatochromism / Robert Greiner ; Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148276114/34.

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18

Vasse, Jean-Luc. "Contrôle de l'axe d'asymétrie masqué de structures lactamiques via l'utilisation d'un relais chiral. Application à la synthèse et l'étude d'une nouvelle génération de modèles du NADH." Rouen, 2000. http://www.theses.fr/2000ROUES049.

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Ce travail concerne la synthèse et l'étude de modèles biomimétiques stables du NADH en séries benzo[b]-1,6-naphthyridine et benzazépino[5,4-b]quinoléine. Leurs accès reposent sur le contrôle d'un axe d'asymétrie masqué par utilisation d'un relais chiral fixe sur le lactame. Cette étude a permis de décomposer deux aspects du transfert énantioselectif de l'équivalent hydrure : la stéréodifférenciation des deux faces du modèle, puis l'organisation du complexe ternaire, via une double complexation de l'ion magnésium. Une attention particulière est accordée à l'amplitude de l'inclinaison de la fonc

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19

Guillier, Fabrice. "Synthèse de produits naturels par association des réactions de métallation et de couplage. Accès à des alcaloïdes marins de type pyridoacridinique." Rouen, 1996. http://www.theses.fr/1996ROUES075.

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Ce travail décrit la préparation de structures de type pyridoacridone par fonctionnalisation de benzo[c][2,7]naphthyridines disubstituées en 4 et 5. Ces composés tétracycliques forment les structures de base pour un grand nombre d'alcaloïdes marins. La méthodologie employée pour la préparation de ces molécules repose sur l'utilisation des réactions de métallation et de couplage biarylique. Un nombre important de systèmes tricycliques de type benzo[c][2,7]naphthyridinique disubstitués en 4 et 5 sont synthétisés en une ou deux étapes à partir de pyridines trisubstituées. Au cours de ce travail,

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20

Bode, Matthias [Verfasser]. "Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine / von Matthias Bode." 2006. http://d-nb.info/979241499/34.

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21

Liao, Chih-Chang, and 廖志彰. "Synthesis and cytotoxicity of 2-(hydroxyphenyl)-6-methyl-1,8-naphthyridin-4-ones and 2-(3-methoxyphenyl)-6-methyl-1,8-naphthyridin-4-one-8-N-oxide." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/94121368727238382567.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>98<br>Abstract In the previous study, 2-(3-methoxyphenyl)-6-methyl-1,8-naphthyridin-4-one（LYF-5）was synthesized and found to possess strong cytotoxicity. Because of its low hydrophilicity, an attempt was made to synthesize of its 4-phosphate. Whereas the poor stability proinhibited it from further development . In this study, two kinds of target compounds, including hydroxyl derivatives（IIa-IIc、IIIa、IVa、IVb） and 8-N-oxide（Va）were designed. Condensation of 2-amiopyridine with benzoyl acetates in PPA formed the corresponding pyrido-pyrimidines（5a-5g）. Thermal

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22

Liu, Chin-Yu, and 劉晉育. "Synthesis of hydrophilic derivatives of 5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridin-4-one." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/03648744475882260917.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>In our previous studies of 2-phenyl-1,8-naphthyridine-4-one (2-PN) derivatives, compounds with a methyl group at the 5- or 6- position, were potent inhibitors of tubulin polymerization and showed remarkable cytoxicity in vitro against leukemia (HL-60), prostate cancer (PC-3), ovarian cancer (OVCAR-3), CNS cancer (SF-295) and melanoma (SF-MEL-5). 2-phenyl-1,8-naphthyridine-4-ones were synthesized according to following steps: condensation of substituted 2-aminopyridines (4,5) with substituted ethyl benzoylacetates (3) in the presence of polyphosphoric aci

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23

Hong, Bei-Tao, and 洪北濤. "Synthetic Study toward 3-(5, 6, 7, 8-Tetrahydro-[1, 8]naphthyridin-2-yl)propionaldehyde." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/28785254494474950487.

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碩士<br>國立中山大學<br>化學系研究所<br>94<br>The starting material 3-sulfonyl-5-methoxy glutarimide was easily prepared via stepwise [3+3] annulation of N-benzyl R-sulfonylacetamide with unsaturated ester as we previously described. We wish we could build tetrahtdronaphthridine skeleton via stretching C-chain, modifying funtional group and RCM, then complete the synthesis of key intermediate of small molecule similar to RGD.

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24

Yu-Fu, Lin, and 林鈺富. "Synthesis and Cytotoxicity of 5, 6, 2'', 3''-Substituted 2-phenyl-1,8-naphthyridin-4-one Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/88768364783242521938.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>92<br>Astract The purpose of this research was to seek for the accurately synthetic method and condition of the PN compounds that our laboratory had developed in the past. This paper was divided into two parts with emphasis. The first part was focused on the way of the heat. The traditional heat was used with the sand bath, and the stable synthetic condition was obtained. In this condition, a series of PN compounds were synthesized. On the other hand, the microwave was used for attempting to enhance the yield. Confirmed after repeated experiment

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25

Lin, Kai-Peng, and 林凱鵬. "Synthesis and Cytotoxicity Activity of 2-(3-Substituted phenyl)-1,8-naphthyridin-4(1H)-one-3-carboxylic Acid." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/08001629995109158937.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>A series of 2-phenyl-1,8-naphthyridin-4(1H)-one (2-PN) derivatives has been synthesized and illustrated very potent cytotoxicity. However, most of them were quite lipophilic and poor pharmacokinetic characteristic for preclinical studies. In order to improve the ADME properties of 2-PNs, several 3-carboxylic acid derivatives were designed and synthesized. The appropriate ethyl benzoylacetate 11-13 were obtained from commercially available 3-substituted acetophenones 8-10 treated with diethyl carbonate, respectively. The acylating agent of N-succinimide este

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26

Kuo, Shih-Ying, and 郭世英. "Synthesis and Studies of Triunclear Metal String Complexes with Bulky Ligand(7-methyl-1,8-naphthyridin-2(1H)-one)." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/265fgx.

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碩士<br>國立臺灣大學<br>化學研究所<br>107<br>In recent years, scientists has fascinated with the concept of single-molecole conducting wire with the advancement of nanotechnology. In this thesis, we focus on extended metal-atom chain about trinuclear second-row transition metal string complexes with bulky ligand Hmnpo (7-methyl-1,8-naphthyridin-2(1H)-one). [Ru3(mnpo)4Cl](PF6) (1) and [RuMoRu(mnpo)4Cl](PF6) (2) have been successfully synthesized. Complex 2 is the first synthesized RuMoRu trinuclear string complex. The molecular structure show that the metal-atoms chains in these complexes are nearly non-hel

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27

Tsai, Chieh Feng, and 蔡傑峰. "Synthesis, Structural Characterization of Dinuclear metal complex,[Ni2L2](H2L = N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl)acetamide)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/224cd5.

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碩士<br>國立臺灣大學<br>化學研究所<br>105<br>The aim of this research is to study the synthesis, structure and properties of the dinuclear nickel complexes which the ligand is N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl) acetamide. The novel asymmetrical ligand was synthesized by palladium-catalyzed reaction which was proposed by S. L. Buchwald , and the product was characterized by NMR and FAB-MS. First of all, we reacted this ligand with Ni(OAc)2∙ 4H2O at high temperature of melt naphthalene, we successfully obtaines one dinuclear compound, [Ni2L2]. The X-ray structure studies of [Ni2L2] reveals the

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28

Chan, Zing-Ping, and 張治平. "Organometallic Complexes containing 1.5-naphthyridine as Electro-Phosphorescent Materials." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/44313599316476992695.

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碩士<br>國立中正大學<br>化學所<br>95<br>Platinum and Iridium complexes containing 3-carbethoxy-4-hydroxy -8-methyl-1,5-naphthyridine ligand with ester substituents were synthesized. OLED devices comprised of these materials were fabricated and examined. Their photo- and electroluminescence emission wavelength ranges from 500-540 nm. The devices exhibit maximum brightness around 50000 cd/m2, and external quantum efficiency of 5.17% for Platinum complexes 6 and 6.05% for Iridium complexes 8. At a current density value of 20 mA/cm2, the devices made from Pt complexes 6 revealed a maximum power efficiency

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Huang, Chang-Yao, and 黃昶堯. "Metal Complexes Containing Naphthyridine Ligands: Synthesis and Catalytic Activity." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69548864114991246305.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>In this work, 2- and 7-substituted 1,8-naphthyridinyl based ligands, 2-(1H-pyrazol-1-yl)-7-methyl-1,8-naphthyridine (4) and 2-(1H-pyrazol-1-yl)-7- carboxyl-1,8-naphthyridine (5) were synthesized. Complexes containing these ligands such as [(4)(h6-benzene)RuCl2] (Ru1), [(5)(h6-benzene)RuCl2] (Ru2), [(5)(h6-p-cymene)RuCl2] (Ru3) and [(5)Rh2(m-OAc)3] (Rh1) were prepared. The resulting complexes have been characterized by spectroscopic methods. Structures of both Ru2 and Ru3 were further confirmed by X-ray crystallography. The carboxyl group on Ru2 enhances its so

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Chen, Po-Hao, and 陳柏豪. "Naphthyridine-based Iridium Complexes:Synthesis and Catalytic Activity on Alkylation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/u36e7y.

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碩士<br>國立臺灣大學<br>化學研究所<br>106<br>In this work, we have developed the syntheses, characterizations and catalytic activities of iridium complexes consisting of pentamethylcyclopentadienyl (Cp*) group and naphthyridine-based ligands. The reaction of naphthyridine-based ligands and [Cp*IrCl2]2 afforded the cyclometalated Ir(III) cationic complexes. The catalytic activities of Ir(III) complexes on N-alkylation of amines with alcohols and α-methylation of ketones with methanol were demonstrated. In particular, we can obtain good yields of α-methylated ketones within short time under mild conditions,

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Chen, Lu-Yu, and 陳律宇. "New naphthyridine-based bipolar host materials for TADF OLED." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/kzhs8n.

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碩士<br>國立臺灣海洋大學<br>光電科學研究所<br>107<br>This thesis is composed of two major parts. The first part is to study a series of bipolar host materials by adjusting the linkage topology to evaluate the performance of OLEDs, namely, o-, m-, p-NPCz and o-, m-, p-NPDa. The devices employing these new bipolar hosts with green thermally activated delayed fluorescence (TADF) doped with 4CzIPN. The device with NPCz as bipolar host exhibits the best device performance with external quantum efficiency of 15.5 ~ 18.4% and green emissions. NPDa as bipolar host exhibits performance with external quantum efficiency

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Chen, Ching-Wen, and 陳靖文. "Design and Synthesis of GMP Chemosensors by Using Naphthyridine Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/11503897340330720910.

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碩士<br>國立臺灣大學<br>化學研究所<br>92<br>GMP recognition is a very important subject in bioorganic chemistry research, because GMP plays a crucial role in message transmission and c DNA (RNA) formation. Recognition of GMP can be used in diagnosis of diseases. This thesis presents the design and synthesis of nitrogen-containing compounds as the hydrogen-bonding receptors for biologically important GMP substrate. We have synthesized several receptors including ANYA, NAEON and NAEN; which consist of amino-substituted naphthyridine moieties for interactions with GMP via multiple hydrogen-bondings. We used f

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Tang, Wei-Hung, and 唐維鴻. "Multidentate 1,8-Naphthyridine Ligand and Its Dinuclear Complexes Catalytic Application." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/35532079986981744539.

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碩士<br>國立臺灣大學<br>化學研究所<br>101<br>Abstract We have successfully prepared a multidentate ligand 2,7-di(2,2′-dipyridylamino) -1,8-naphthyridine (4), and its ruthenium dinuclear complexes. The use of the prepared ruthenium complex as the catalyst for the cycloaddition of o-phenylenediamine with ethyleneglycol was investigated. For the ligand synthesis, the coupling reaction of C-N bond between 2,7-di- chloro-1,8-naphthyridine (3) and 2,2′-dipyridylamine yielded 4, which has six coordination sites for the metal. Coordination of 4 with [(η6-p-cymene)RuCl2]2、[Cu(CH3CN)4PF6]、 CuI and CuBr resulted in

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Chu, Chia-Ho, and 朱家禾. "Naphthyridine-based Rhodium Complexes:Synthesis and Catalytic Activity on Transfer Hydrogenation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/yud6h6.

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碩士<br>國立臺灣大學<br>化學研究所<br>107<br>In this work, we have explored the syntheses, characterizations and catalytic activities of rhodium complexes containing both pentamethylcyclopentadienyl (Cp*) group and naphthyridine-based ligands. Upon the reaction between naphthyridine-based ligands and [Cp*RhCl2]2 afforded the cyclometalated Rh(III) cationic complexes. Rh(III) complexes display good activities on catalytic transfer hydrogenation reactions. Quinoline can be reduced into 1,2,3,4-Tetrahydroquinolines (THQs) with HCOOH/HCOONa as the hydride source under ambient condition in water. In addition, w

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35

Lu, Shao Hung, and 呂紹宏. "Molecular Recognition of Guanine by Ethynyl-Linked Aniline-Naphthyridine Conjugated Molecules." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/39872035561852977410.

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碩士<br>國立臺灣大學<br>化學研究所<br>94<br>Abstract In this thesis we develop the hydrogen-bonding receptors based on the ethynyl-linked aniline−naphthyridene molecules（APENA、Ac-APENA and Me-APENA ） for the biologically important Guanine substrate. We investigate their photophysical properties, binding affinity and the related experiments. The receptors Ac-APENA and Me-APENA show good and selective binding affinity for guanine derivatives. The binding of Ac-APENA and Me-APENA with Guanine（G-10）causes fluorescence quench. The calculation indicates the binding affinity is very high, Ka = 64200 and 90800 M-1

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Ho, Hsiang-Wei, and 何緗煒. "Synthesis and biological activity of naphthyridine derivatives as potential Akt inhibitors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/52256652298518462423.

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碩士<br>東海大學<br>化學系<br>99<br>PI3K/Akt signaling pathway plays a key role in human cancers. Overexpression of Akt causes abnormal cell proliferation and result in cancer. Therefore, Akt is an attractive therapeutic target for cancer treatment. We have designed series of aminoindole and naphthyridine derivatives as potential Akt inhibitors. The synthesis of aminoindole derivatives by Buchwald-Hartwig cross-coupling, were unfortunately not successful with changes in reaction conditions. Series of naphthyridine derivatives were synthesized by Skraup and Doebner-Miller quinoline synthesis. CL1-0 lung

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許士杰. "Design and Synthesis of Carbohydrate Molecular Sensor Constructed by Naphthyridine and Pyridines." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/49970917577539863960.

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碩士<br>國立臺灣大學<br>化學研究所<br>91<br>Selective carbohydrate recognition is a very important subject in bioorganic chemistry research. Saccharide motifs are known to mediate cell-cell recognition and promote the cellular processes. To design a good receptor for recognition of carbohydrates become an important research area. Because a carbohydrate molecule contains multiple functional groups and three-dimensional structure, it is also a challenging task to design the suitable carbohydrate receptor. Thus, we have designed and synthysized carbohydrate receptors of BPYN, BPDN, and TPYN, which are constru

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Luo, Yu-Jie, and 羅毓傑. "Study of ruthenium complexes with 7-acetylamino-1,8-naphthyridine-2-carboxylic acid." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/14429695395540444911.

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Wei, Chun-Ju, and 魏君如. "Metallo-supramolecules Based on Zinc and Silver Complexes with Naphthyridine-Dimine Ligand." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/33750039407180129783.

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碩士<br>淡江大學<br>化學學系碩士班<br>96<br>In this research, a series of new ligands containing hydrazone and derivative naphthyridine moiety were synthesized successfully, after complexed with binding Zn (II) , gives sandwich like complexes , namely, [Zn2(C2-Me-(Dmenpt)2)2(OH)2(CH3OH)2](ClO4)2 1 、[Zn2(C2-H-(Dmenpt)2)2(OH)2(H2O)2](ClO4)2 2 ，and planar structure ，[Zn(Py-Me-(Dmenpt)2)(CH3OH)2](ClO4)2 3 、 [Zn(C2-Me-(Npt)2)(CH3OH)2](ClO4)2 4， and complexes with silver(I) to formed tetranuclear helicate , namely, [Ag4(C2-Me-(Npt)2)2](CF3SO3)4 5 .The crystal structures of the complexes have been determined

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Liao, Bei-Sih, and 廖倍偲. "Synthesis of Metalloporphyrins and Dimetal Di(pyridyl)naphthyridine Complexes and Their Catalytic Activities." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87745096773623641841.

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博士<br>國立臺灣大學<br>化學研究所<br>100<br>Metal porphyrins can act as important active site in the organism. Accordingly, the design of metal porphyrin complexes that are able to efficiently catalyze synthetic reactions is of great interest. We have synthesized a series of metalporphyrins (2d-g) with trifluoromethyl group and hydrophilic substitutes. Synthetic metalloporphyrins have been used in a variety of oxidation reactions as catalysts. Iron(III) porphyrin complex 2d was found to catalyze the oxidation of 1-ethylbenzene with NHPI as a co-catalyst. Ruthenium(II) porphyrin complex 2g can oxidize phen

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Ndaba, Hlengiwe Glenrose. "Microwave as an energy source in the synthesis of 2-aryl-4-quinolone alkaloids and naphthyridines." Thesis, 2011. http://hdl.handle.net/10321/704.

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Thesis submitted in fulfilment of the requirements for the Degree of Masters of Technology: Organic Chemistry, Durban University of Technology, 2011.<br>One of the greatest medical challenges facing mankind is the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) which has now become a major epidemic with more than 40 million people infected worldwide. Of equal concern is its implication in high mortality and the onset of a number of opportunist mycobacterial infections, principally tuberculosis. In spite of the discovery of some relatively effective antiretroviral

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Yang, Fu-Ming, and 楊富明. "Synthesis of the 2,7-bis(2-pyridyl)-1,8-naphthyridine Ligand and its Palladium Complexes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/58670136280243761625.

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碩士<br>國立臺灣大學<br>化學研究所<br>99<br>2,7 –Bis(2-pyridyl)-1,8-naphthyridine (bpnp) is a multiple pyridinyl nitrogen donor, which is capable of binding with metal ions in a chelating manner. In case of coordination with two metal ions, these centers are in close distance to have metal-metal interactions, which raises a subject of considerable interest. In our work, we tried to synthesize the dipalladium complex with bpnp. Indeed, we have successfully obtained a palladium complex chelated with bpnp, but in a trimetallic form. The structure of the complex is revealed by X-ray single crystal analysis.

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Lee, Chia-Han, and 李佳翰. "Syntheses of Transition Metal Complexes Containing a Naphthyridine Dicarboxylate Ligand and Catalytic Activity Study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/65221308035527879561.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>Dimetallic complexes are known to have unique properties in transition metal catalyzed reactions, and there are a lot of examples proving the cooperation between metals during the catalysis. Therefore, there is a need to design and synthesis of multi-dentate ligands for construction of dimetallic systems. In this research, 1,8-naphthyridine-2,7-dicarboxylate was used as the multi-dentate ligand for complexation with ruthenium, copper and cobalt ions to form Cu2(I, I), [Co2(II, II)]2 and Ca[Ru2(II, II)]2. Moreover, we successfully disclosed their absolute str

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Wang, Ya-Ching, and 王雅靜. "Dibenzo[b,f ][1,7]naphthyridine derivatives as photosensitizers for the treatment of skin cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/76296634895000150114.

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碩士<br>高雄醫學大學<br>生物科技學系碩士班<br>104<br>Previse study showed that quinolone ring has significant bioactive in anticancer. The famous nature anticancer drug Camptothecin that has quinolone ring can treat with skin cancer, but this drug has serious side effects. Thus, we imitated Camptothecin structure to synthesis Dibenzo[b,f ][1,7]naphthyridine derivatives (7) which can absorb light in the UV range. We expected that these derivatives could act as exogenous photosensitizers of photodynamic therapy (PDT) for treating skin cancer cells. Three cancer cells including basal-cell carcinoma (BCC) and mali

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Cheng, Chien-Hung, and 鄭健鴻. "Synthetic, Structural, and Magnetic Studies of Trinickel String Complexes Supported by Thione-naphthyridine Ligands." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8467bj.

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碩士<br>國立臺灣大學<br>化學研究所<br>106<br>Recently, it has been shown that the introduction of a planar NNO based ligand scaffold in metal string complexes plays a pivot role in boosting the single molecule conductance. Inspired by this study, herein we report the preliminary investigation on the novel trinickel string complexes [Ni3(npt)4(Cl)] (1) and [Ni3(npt)4(NCS)] (3) supported by NNS type ligand. The cyclic voltammetry of complex 3 exhibits only one-electron redox processes at E1/2 = 0.301 V. The one-electron oxidation species [Ni3(npt)4(Cl)](PF6) (2) and [Ni3(npt)4(NCS)](PF6) (4) can be synthesiz

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Huang, Hsiao-Ching, and 黃筱晴. "Metal Complexes with a Naphthyridine-Based N-Heterocyclic Carbene (NHC) Lignad: Synthesis and Catalytic Activities." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/79407553763951844389.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>In this work, we explored the syntheses, characterization and catalytic activity of metal complexes containing a naphthyridine-based N-heterocyclic carbene ligand. The desired rhodium(I), iridium(I) and palladium(II) complexes were obtained via a known carbene transfer method. The reaction of naphthyridine-based NHC ligand 6, silver nitrate and potassium carbonate afforded the silver bis-carbene complex 7. Upon the reaction between the silver NHC complex with [Rh(COD)Cl]2 or [Ir(COD)Cl]2, the carbene fragment readily transferred from silver to rhodium and iridiu

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Lan, Yung-Syuan, and 藍詠萱. "Synthesis and Catalytic Application of Dimetal complex with 2,7-bis(2-pyridyl)-1,8-naphthyridine ligand." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/61127016587196660962.

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碩士<br>國立臺灣大學<br>化學研究所<br>100<br>This work involves the coordination study of a pyridinyl ligand 2,7-bis(2-pyridyl)-1,8-naphththyridine (bpnp) with various transition metal ions including Mn, Cu and Pd and catalytic activity of the resulting dicopper complex. Reaction of bpnp with [MnCl2] provided a mononuclear dimmer [{Mn(bpnp)(OMe)Cl2}(μ-Cl)2]. Such a manganese complex could undergo the metal exchange with Cu(II) ions to form a dinuclear species [Cu2(bpnp)(Cl)3(OH)]. Reaction of bpnp with Cu2O provided a dinuclear species [Cu2(bpnp)(HCOO)3(OH)]. These complexes were isolated and characterize

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48

Lu, Shao-Hung, and 呂紹宏. "Design of 1,8-Naphthyridine Derivatives for Molecular Recognition of Guanine and Quadruplex DNA in Water." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/26672572895194394813.

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博士<br>國立臺灣大學<br>化學研究所<br>99<br>This thesis consists of two parts. The first part is molecular recognition of guanosine phosphates by ethynyl-linked aniline-naphthyridine conjugated molecules in water; the second part is to design and synthesize water-soluble receptors for binding with quadruplex DNA. In the first part, the ethynyl-linked aniline-naphthyridene molecules (Sa-APENA、Diol-APENA、Ol-APENA and Am-APENA) were synthesized and used as the hydrogen-bonding receptors of a biologically important substrate Guanine. We investigated their photophysical properties and binding affinity. The re

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49

Wang, Rui-Ren, та 王瑞仁. "Syntheses and Studies of Geometric Isomers of Tetranickel Strings with 2-α-Pyridylamino-1,8-Naphthyridine Ligand". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/90618007396499244294.

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博士<br>國立臺灣大學<br>化學研究所<br>95<br>The goal of this thesis is to study isomer effect to the influence of the metal string complexes. Here we presented the design and preparation of new unsymmetrical tetradentate ligands and the investigation of their linear tetranickel string complexes. X-ray structures, electrochemistry and magnetism of the linear tetranickel string complexes were studied. (1) Three new ligands, 2-α-pyridylamino-1,8-naphthyridine (Hpyany), 2-α-pyrazaylylamino-1,8-naphthyridine (Hpzany), 2-α-picodylamino-1,8-naphthyridine (Hpcany), were synthesized by the palladium-catalyzed cross

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Lin, Chao-Jung, and 林昭蓉. "Synthesis of Carbamate and Amine derivatives of(5 or 6)-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/47037739675343332384.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6a) and 6-methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6b) have been synthesized and shown potent cytotoxicity. However, during the undergoing in vivo tests and other preclinical studies, their limited water solubility complicated the issues of IV preparation and oral formulation. To simplify these issues several carbamate and amine derivatives of 6a were synthesized and their cytotoxicity were examined. Strangely, attempted to introduce a bromo group into the benzylic carbon of 6a or 6b by treatment with NBS

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