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Dissertations / Theses on the topic 'Naphthyridines – Synthesis'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Ye, Guozhong. "Synthesis and reactions of cyclic ketene-N,N-acetals." Diss., Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-09142008-210135.

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2

Fernandez, Sarah [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Chromium- and cobalt-catalyzed cross-coupling and amination reactions and synthesis and reactivity of Pyrido[3,2-f][1,7]naphthyridines / Sarah Fernandez. Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1104128934/34.

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3

Devaux, Floriane. "Synthesis and AFM-based single-molecule force spectroscopy of helical aromatic oligoamide foldamers." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0346.

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Les foldamères sont des architectures moléculaires synthétiques repliées, inspirées par les structures et les fonctions des biopolymères naturels. Le repliement est un processus sélectionné par la nature pour contrôler la conformation de sa machinerie moléculaire afin de réaliser des tâches chimiques ou mécaniques. Durant les dix dernières années de recherche sur les foldamères, des oligomères synthétiques, capables d'adopter des conformations repliées bien définies et prévisibles, comme des hélices, ont été proposés. Les progrès récents ont montré que la synthèse chimique par étapes et le des

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4

Mefetah, Hafid. "Benzo(b)-1,8-naphthyridine-5-one : synthese et activite antiparasitaire de nouveaux derives n-alkyles : synthese et caracterisation de tetracycles derives de la molecule-titre." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22956.

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5

Harris, Cragin K. "Synthesis and Characterization of Five New Tetrakis(N-phenylacetamidato) Dirhodium(II) Amine Complexes and One Molybdenum Cofactor Described Crystallographically." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2525.

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Six new crystal structures were determined using a Rigaku Mercurcy 375/MCCD(XtaLab mini) diffractometer. The structure of a molybdenum cofactor was solved resulting in an R1 (R1 = Σ ||Fo| - |Fc|| / Σ |Fo|) of 3.61% despite the presence of a disordered DMSO molecule. New Tetrakis(N-phenylacetamidato) Dirhodium(II) complexes were synthesized and characterized. Two 2,2-cis-[Rh2(NPhCOCH3)4]•(C3H4N2)x where x= 1 or 2 were successfully crystallized and solved with R1 values below 5%. Additional studies were conducted via NMR to observe formation of both products. Three potential catalysts were synth

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6

Guillier, Fabrice. "Synthèse de produits naturels par association des réactions de métallation et de couplage. Accès à des alcaloïdes marins de type pyridoacridinique." Rouen, 1996. http://www.theses.fr/1996ROUES075.

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Ce travail décrit la préparation de structures de type pyridoacridone par fonctionnalisation de benzo[c][2,7]naphthyridines disubstituées en 4 et 5. Ces composés tétracycliques forment les structures de base pour un grand nombre d'alcaloïdes marins. La méthodologie employée pour la préparation de ces molécules repose sur l'utilisation des réactions de métallation et de couplage biarylique. Un nombre important de systèmes tricycliques de type benzo[c][2,7]naphthyridinique disubstitués en 4 et 5 sont synthétisés en une ou deux étapes à partir de pyridines trisubstituées. Au cours de ce travail,

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7

Ndaba, Hlengiwe Glenrose. "Microwave as an energy source in the synthesis of 2-aryl-4-quinolone alkaloids and naphthyridines." Thesis, 2011. http://hdl.handle.net/10321/704.

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Thesis submitted in fulfilment of the requirements for the Degree of Masters of Technology: Organic Chemistry, Durban University of Technology, 2011.<br>One of the greatest medical challenges facing mankind is the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) which has now become a major epidemic with more than 40 million people infected worldwide. Of equal concern is its implication in high mortality and the onset of a number of opportunist mycobacterial infections, principally tuberculosis. In spite of the discovery of some relatively effective antiretroviral

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8

Huang, Chang-Yao, and 黃昶堯. "Metal Complexes Containing Naphthyridine Ligands: Synthesis and Catalytic Activity." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69548864114991246305.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>In this work, 2- and 7-substituted 1,8-naphthyridinyl based ligands, 2-(1H-pyrazol-1-yl)-7-methyl-1,8-naphthyridine (4) and 2-(1H-pyrazol-1-yl)-7- carboxyl-1,8-naphthyridine (5) were synthesized. Complexes containing these ligands such as [(4)(h6-benzene)RuCl2] (Ru1), [(5)(h6-benzene)RuCl2] (Ru2), [(5)(h6-p-cymene)RuCl2] (Ru3) and [(5)Rh2(m-OAc)3] (Rh1) were prepared. The resulting complexes have been characterized by spectroscopic methods. Structures of both Ru2 and Ru3 were further confirmed by X-ray crystallography. The carboxyl group on Ru2 enhances its so

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9

Chen, Ching-Wen, and 陳靖文. "Design and Synthesis of GMP Chemosensors by Using Naphthyridine Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/11503897340330720910.

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碩士<br>國立臺灣大學<br>化學研究所<br>92<br>GMP recognition is a very important subject in bioorganic chemistry research, because GMP plays a crucial role in message transmission and c DNA (RNA) formation. Recognition of GMP can be used in diagnosis of diseases. This thesis presents the design and synthesis of nitrogen-containing compounds as the hydrogen-bonding receptors for biologically important GMP substrate. We have synthesized several receptors including ANYA, NAEON and NAEN; which consist of amino-substituted naphthyridine moieties for interactions with GMP via multiple hydrogen-bondings. We used f

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10

Ho, Hsiang-Wei, and 何緗煒. "Synthesis and biological activity of naphthyridine derivatives as potential Akt inhibitors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/52256652298518462423.

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碩士<br>東海大學<br>化學系<br>99<br>PI3K/Akt signaling pathway plays a key role in human cancers. Overexpression of Akt causes abnormal cell proliferation and result in cancer. Therefore, Akt is an attractive therapeutic target for cancer treatment. We have designed series of aminoindole and naphthyridine derivatives as potential Akt inhibitors. The synthesis of aminoindole derivatives by Buchwald-Hartwig cross-coupling, were unfortunately not successful with changes in reaction conditions. Series of naphthyridine derivatives were synthesized by Skraup and Doebner-Miller quinoline synthesis. CL1-0 lung

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11

許士杰. "Design and Synthesis of Carbohydrate Molecular Sensor Constructed by Naphthyridine and Pyridines." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/49970917577539863960.

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碩士<br>國立臺灣大學<br>化學研究所<br>91<br>Selective carbohydrate recognition is a very important subject in bioorganic chemistry research. Saccharide motifs are known to mediate cell-cell recognition and promote the cellular processes. To design a good receptor for recognition of carbohydrates become an important research area. Because a carbohydrate molecule contains multiple functional groups and three-dimensional structure, it is also a challenging task to design the suitable carbohydrate receptor. Thus, we have designed and synthysized carbohydrate receptors of BPYN, BPDN, and TPYN, which are constru

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12

Liao, Bei-Sih, and 廖倍偲. "Synthesis of Metalloporphyrins and Dimetal Di(pyridyl)naphthyridine Complexes and Their Catalytic Activities." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87745096773623641841.

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博士<br>國立臺灣大學<br>化學研究所<br>100<br>Metal porphyrins can act as important active site in the organism. Accordingly, the design of metal porphyrin complexes that are able to efficiently catalyze synthetic reactions is of great interest. We have synthesized a series of metalporphyrins (2d-g) with trifluoromethyl group and hydrophilic substitutes. Synthetic metalloporphyrins have been used in a variety of oxidation reactions as catalysts. Iron(III) porphyrin complex 2d was found to catalyze the oxidation of 1-ethylbenzene with NHPI as a co-catalyst. Ruthenium(II) porphyrin complex 2g can oxidize phen

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13

Yang, Fu-Ming, and 楊富明. "Synthesis of the 2,7-bis(2-pyridyl)-1,8-naphthyridine Ligand and its Palladium Complexes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/58670136280243761625.

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碩士<br>國立臺灣大學<br>化學研究所<br>99<br>2,7 –Bis(2-pyridyl)-1,8-naphthyridine (bpnp) is a multiple pyridinyl nitrogen donor, which is capable of binding with metal ions in a chelating manner. In case of coordination with two metal ions, these centers are in close distance to have metal-metal interactions, which raises a subject of considerable interest. In our work, we tried to synthesize the dipalladium complex with bpnp. Indeed, we have successfully obtained a palladium complex chelated with bpnp, but in a trimetallic form. The structure of the complex is revealed by X-ray single crystal analysis.

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14

Lan, Yung-Syuan, and 藍詠萱. "Synthesis and Catalytic Application of Dimetal complex with 2,7-bis(2-pyridyl)-1,8-naphthyridine ligand." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/61127016587196660962.

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碩士<br>國立臺灣大學<br>化學研究所<br>100<br>This work involves the coordination study of a pyridinyl ligand 2,7-bis(2-pyridyl)-1,8-naphththyridine (bpnp) with various transition metal ions including Mn, Cu and Pd and catalytic activity of the resulting dicopper complex. Reaction of bpnp with [MnCl2] provided a mononuclear dimmer [{Mn(bpnp)(OMe)Cl2}(μ-Cl)2]. Such a manganese complex could undergo the metal exchange with Cu(II) ions to form a dinuclear species [Cu2(bpnp)(Cl)3(OH)]. Reaction of bpnp with Cu2O provided a dinuclear species [Cu2(bpnp)(HCOO)3(OH)]. These complexes were isolated and characterize

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15

Huang, Hsiao-Ching, and 黃筱晴. "Metal Complexes with a Naphthyridine-Based N-Heterocyclic Carbene (NHC) Lignad: Synthesis and Catalytic Activities." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/79407553763951844389.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>In this work, we explored the syntheses, characterization and catalytic activity of metal complexes containing a naphthyridine-based N-heterocyclic carbene ligand. The desired rhodium(I), iridium(I) and palladium(II) complexes were obtained via a known carbene transfer method. The reaction of naphthyridine-based NHC ligand 6, silver nitrate and potassium carbonate afforded the silver bis-carbene complex 7. Upon the reaction between the silver NHC complex with [Rh(COD)Cl]2 or [Ir(COD)Cl]2, the carbene fragment readily transferred from silver to rhodium and iridiu

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16

Lee, Chia-Han, and 李佳翰. "Syntheses of Transition Metal Complexes Containing a Naphthyridine Dicarboxylate Ligand and Catalytic Activity Study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/65221308035527879561.

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碩士<br>國立臺灣大學<br>化學研究所<br>102<br>Dimetallic complexes are known to have unique properties in transition metal catalyzed reactions, and there are a lot of examples proving the cooperation between metals during the catalysis. Therefore, there is a need to design and synthesis of multi-dentate ligands for construction of dimetallic systems. In this research, 1,8-naphthyridine-2,7-dicarboxylate was used as the multi-dentate ligand for complexation with ruthenium, copper and cobalt ions to form Cu2(I, I), [Co2(II, II)]2 and Ca[Ru2(II, II)]2. Moreover, we successfully disclosed their absolute str

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17

Lin, Chao-Jung, and 林昭蓉. "Synthesis of Carbamate and Amine derivatives of(5 or 6)-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/47037739675343332384.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6a) and 6-methyl-2-(3-methoxyphenyl)-1,8-naphthyridine (6b) have been synthesized and shown potent cytotoxicity. However, during the undergoing in vivo tests and other preclinical studies, their limited water solubility complicated the issues of IV preparation and oral formulation. To simplify these issues several carbamate and amine derivatives of 6a were synthesized and their cytotoxicity were examined. Strangely, attempted to introduce a bromo group into the benzylic carbon of 6a or 6b by treatment with NBS

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18

Liao, Chih-Chang, and 廖志彰. "Synthesis and cytotoxicity of 2-(hydroxyphenyl)-6-methyl-1,8-naphthyridin-4-ones and 2-(3-methoxyphenyl)-6-methyl-1,8-naphthyridin-4-one-8-N-oxide." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/94121368727238382567.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>98<br>Abstract In the previous study, 2-(3-methoxyphenyl)-6-methyl-1,8-naphthyridin-4-one（LYF-5）was synthesized and found to possess strong cytotoxicity. Because of its low hydrophilicity, an attempt was made to synthesize of its 4-phosphate. Whereas the poor stability proinhibited it from further development . In this study, two kinds of target compounds, including hydroxyl derivatives（IIa-IIc、IIIa、IVa、IVb） and 8-N-oxide（Va）were designed. Condensation of 2-amiopyridine with benzoyl acetates in PPA formed the corresponding pyrido-pyrimidines（5a-5g）. Thermal

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19

Liu, Chin-Yu, and 劉晉育. "Synthesis of hydrophilic derivatives of 5-Methyl-2-(3-methoxyphenyl)-1,8-naphthyridin-4-one." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/03648744475882260917.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>In our previous studies of 2-phenyl-1,8-naphthyridine-4-one (2-PN) derivatives, compounds with a methyl group at the 5- or 6- position, were potent inhibitors of tubulin polymerization and showed remarkable cytoxicity in vitro against leukemia (HL-60), prostate cancer (PC-3), ovarian cancer (OVCAR-3), CNS cancer (SF-295) and melanoma (SF-MEL-5). 2-phenyl-1,8-naphthyridine-4-ones were synthesized according to following steps: condensation of substituted 2-aminopyridines (4,5) with substituted ethyl benzoylacetates (3) in the presence of polyphosphoric aci

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20

Cheng, Chien-Hung, and 鄭健鴻. "Synthetic, Structural, and Magnetic Studies of Trinickel String Complexes Supported by Thione-naphthyridine Ligands." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8467bj.

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碩士<br>國立臺灣大學<br>化學研究所<br>106<br>Recently, it has been shown that the introduction of a planar NNO based ligand scaffold in metal string complexes plays a pivot role in boosting the single molecule conductance. Inspired by this study, herein we report the preliminary investigation on the novel trinickel string complexes [Ni3(npt)4(Cl)] (1) and [Ni3(npt)4(NCS)] (3) supported by NNS type ligand. The cyclic voltammetry of complex 3 exhibits only one-electron redox processes at E1/2 = 0.301 V. The one-electron oxidation species [Ni3(npt)4(Cl)](PF6) (2) and [Ni3(npt)4(NCS)](PF6) (4) can be synthesiz

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21

Tsou, Lien-Hung, та 鄒連宏. "Synthesis and Structure of Oligo-nuclear Metal-Chain Complexes with the 2-α-Pyridylamino-1,8- Naphthyridine Ligand". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/49653671922908556625.

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碩士<br>國立臺灣大學<br>化學研究所<br>100<br>The goal of this thesis is to synthesize heteronuclear metal string including nickel and molybdenum with 2-α-pyridylamino-1,8-naphthyridine (Hpyany) . The Mo -Mo bond distance of [Mo2(Hpyany)2(pyany)2](PF6)2 is about 2.09 A which corresponds to a metal - metal quadruple bond. There are two ligands without deprotonation. The tetranuclear linear metal chain, [Mo2Ni2(pyany)4(Cl)2](ClO4), is helically wrapped by four all syn form type ligands. The metals of nickel and molybdenum arrange in order of Mo1-Mo2-Ni1-Ni2 with Cl- axial ligands both at two side of metal

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22

Wang, Rui-Ren, та 王瑞仁. "Syntheses and Studies of Geometric Isomers of Tetranickel Strings with 2-α-Pyridylamino-1,8-Naphthyridine Ligand". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/90618007396499244294.

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博士<br>國立臺灣大學<br>化學研究所<br>95<br>The goal of this thesis is to study isomer effect to the influence of the metal string complexes. Here we presented the design and preparation of new unsymmetrical tetradentate ligands and the investigation of their linear tetranickel string complexes. X-ray structures, electrochemistry and magnetism of the linear tetranickel string complexes were studied. (1) Three new ligands, 2-α-pyridylamino-1,8-naphthyridine (Hpyany), 2-α-pyrazaylylamino-1,8-naphthyridine (Hpzany), 2-α-picodylamino-1,8-naphthyridine (Hpcany), were synthesized by the palladium-catalyzed cross

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23

Tsai, Bing-Chen, and 蔡秉辰. "Synthesis and Catalytic Application of Dimetal Complexes with 2-(pyrazol-1-yl)-7-(2-pyridyl)-1,8-naphthyridine ligand." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/17421292411007953274.

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碩士<br>國立臺灣大學<br>化學研究所<br>103<br>The discovery of bimetallic centers in enzymes makes chemists research the structure which can accommodate two metal ions simultaneously in order to mimic the activity of enzymes. In this work, we have successively synthesized mono-, bi-metallic complexes using 2-(pyrazol-1-yl)-7-(2-pyridyl)-1,8-naphthyridine (ppnp) as multidentate. Among them, the structures of diRu and diNi can be confirmed with single crystals. The crystal structures both showed that ppnp coordinated with two metals to form two five-member rings. In diRu, two ruthenium ions linked by Ru-Ru do

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24

Yu-Fu, Lin, and 林鈺富. "Synthesis and Cytotoxicity of 5, 6, 2'', 3''-Substituted 2-phenyl-1,8-naphthyridin-4-one Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/88768364783242521938.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>92<br>Astract The purpose of this research was to seek for the accurately synthetic method and condition of the PN compounds that our laboratory had developed in the past. This paper was divided into two parts with emphasis. The first part was focused on the way of the heat. The traditional heat was used with the sand bath, and the stable synthetic condition was obtained. In this condition, a series of PN compounds were synthesized. On the other hand, the microwave was used for attempting to enhance the yield. Confirmed after repeated experiment

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25

Liao, Szu-Hung, and 廖思虹. "Synthesis and Characterization of Wide Band-Gap Naphthyridinol Metal Chelates and their Applications to Blue Fluorescence OLEDs." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/11397619995573631083.

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碩士<br>國立臺灣師範大學<br>化學系<br>96<br>Green tris-(8-hydroxyquinoline)aluminum is one of the most useful metal chelates for organic light emitting diodes (OLEDs). By changing 5-position CH to N and adding methyl or phenyl substituent on 4- and 6- position of 8-hydroxylquinoline, a series of blue light-emitting metal (Al3+, Ga3+, In3+, Mg2+, Zn2+, or Hf4+) chelates 4-methyl-[1.5]-naph- thyridin-8-ol (mND), 4,6-methyl-[1,5]-naphthyridin-8-ol (mmND), and 8-methyl-2-phenyl-[1,5]naphthyridin-4-ol (mpND) were successfully synthesized and characterized. These new metal chelates are all blue to deep blue flu

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Yeh, Che-Wei, and 葉哲維. "Synthesis, Crystal Structures and Physical Properties of a Series of Linear Tetranickle Complexes with the Naphthyridine-Functionalized Amine Ligands." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/98713583099461440228.

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碩士<br>國立臺灣大學<br>化學研究所<br>96<br>Three types of metal complexes with naphthyridine-functionalized amine ligands, 2-α-pyridylamino-1,8-naphthyridine (Hpyany) and N-1,8-naphthyridyl methylamide (Hnyma) have been prepared. First, a series of linear tetranickel complexes coordinated by two kinds of ligands, Hpyany and p-toluenesulfonyl di-pyridyl-di-amine (H2Tsdpda), have been synthesized. Their structures were determined by single-crystal X-ray diffraction analysis. The ligands, Hpyany and H2Tsdpda, have been deprotonated to act as tetradentate ligands and helically wrapped the nickel metal ions to

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Huang, Guei-Fen, та 黃桂芬. "Syntheses and Studies of Linear Heterometallic String Complexes with the 2,7-bis(α-pyridylamino)-1,8-naphthyridine Ligand (H2bpyany)". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/3xahqu.

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碩士<br>國立臺灣大學<br>化學研究所<br>105<br>In the past decades, molecular electronics have been widely researched in many fields and extended metal atom chains (EMACs) are of considerable significance for their potential applications in molecular wires and nanoelectronics. In order to develop new generation of metal string complexes, a heterometallic framework have been studied. Compared to homonuclear complexes, the structure, magnetic properties and resistance of mixed metal complexes are versatile. Therefore, the aim of this thesis is to synthesize linear oligo-nuclear metal string complexes with the

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28

Lin, Kai-Peng, and 林凱鵬. "Synthesis and Cytotoxicity Activity of 2-(3-Substituted phenyl)-1,8-naphthyridin-4(1H)-one-3-carboxylic Acid." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/08001629995109158937.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>A series of 2-phenyl-1,8-naphthyridin-4(1H)-one (2-PN) derivatives has been synthesized and illustrated very potent cytotoxicity. However, most of them were quite lipophilic and poor pharmacokinetic characteristic for preclinical studies. In order to improve the ADME properties of 2-PNs, several 3-carboxylic acid derivatives were designed and synthesized. The appropriate ethyl benzoylacetate 11-13 were obtained from commercially available 3-substituted acetophenones 8-10 treated with diethyl carbonate, respectively. The acylating agent of N-succinimide este

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Lin, Yirn Ying, and 林吟霙. "Synthesis and Antiarrhythmic Activities of N-substituted benzyl-7-methyl-2,3,4,9-tetrahydrofuro[2,3-b]naphthyridine-3,4- diones and Related Compounds." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/23575166994201851543.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>85<br>SUMMARY In order to develop new antiarrhythmic agents , we synthesed two series of furoquinolone compounds , (I) : N-substituted benzyl-7- methyl-2,3,4,9-tet rahydrofuro-[2,3-b]naphthyridines 5-19 and (II):N-substituted benzyl-7-methyl -2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-diones 20-34. Structures of these compounds were identified by MS , IR,UV,1H- NMR and 13C-NMR spectral data . The first series of these compounds 5-19 were evaluated f

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30

Hong, Bei-Tao, and 洪北濤. "Synthetic Study toward 3-(5, 6, 7, 8-Tetrahydro-[1, 8]naphthyridin-2-yl)propionaldehyde." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/28785254494474950487.

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碩士<br>國立中山大學<br>化學系研究所<br>94<br>The starting material 3-sulfonyl-5-methoxy glutarimide was easily prepared via stepwise [3+3] annulation of N-benzyl R-sulfonylacetamide with unsaturated ester as we previously described. We wish we could build tetrahtdronaphthridine skeleton via stretching C-chain, modifying funtional group and RCM, then complete the synthesis of key intermediate of small molecule similar to RGD.

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Kuo, Shih-Ying, and 郭世英. "Synthesis and Studies of Triunclear Metal String Complexes with Bulky Ligand(7-methyl-1,8-naphthyridin-2(1H)-one)." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/265fgx.

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碩士<br>國立臺灣大學<br>化學研究所<br>107<br>In recent years, scientists has fascinated with the concept of single-molecole conducting wire with the advancement of nanotechnology. In this thesis, we focus on extended metal-atom chain about trinuclear second-row transition metal string complexes with bulky ligand Hmnpo (7-methyl-1,8-naphthyridin-2(1H)-one). [Ru3(mnpo)4Cl](PF6) (1) and [RuMoRu(mnpo)4Cl](PF6) (2) have been successfully synthesized. Complex 2 is the first synthesized RuMoRu trinuclear string complex. The molecular structure show that the metal-atoms chains in these complexes are nearly non-hel

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Tsai, Chieh Feng, and 蔡傑峰. "Synthesis, Structural Characterization of Dinuclear metal complex,[Ni2L2](H2L = N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl)acetamide)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/224cd5.

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碩士<br>國立臺灣大學<br>化學研究所<br>105<br>The aim of this research is to study the synthesis, structure and properties of the dinuclear nickel complexes which the ligand is N-(6-(1,8-naphthyridin-7-ylamino)pyridin-2-yl) acetamide. The novel asymmetrical ligand was synthesized by palladium-catalyzed reaction which was proposed by S. L. Buchwald , and the product was characterized by NMR and FAB-MS. First of all, we reacted this ligand with Ni(OAc)2∙ 4H2O at high temperature of melt naphthalene, we successfully obtaines one dinuclear compound, [Ni2L2]. The X-ray structure studies of [Ni2L2] reveals the

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Lin, Geng-Min, та 林耿民. "Syntheses and Studies of Fine Tuning of 2,7-bis(α-pyridylamino)-1,8-naphthyridine Ligand and Their Linear Oligo-Nuclear Metal Strings". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/xv5c73.

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博士<br>國立臺灣大學<br>化學研究所<br>104<br>In the past several decades, molecular electronics have been widely discussed in many fields and extended metal atom chains (EMACs) are of considerable significance for their potential applications as molecular wires. In order to develop new generation of metal string complexes, two series of them, which contain fine tuning of ligands or a heterometallic framework, have been studied. Ligands such as oligo-α-pyridylamines and oligo-naphthyridylamine are usually used in the linear metal string complex, and another series of ligands made up of pyridyl and naphthyri

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Chen, Guan-Ting, та 陳冠廷. "Syntheses and Studies of Linear Pentanickel Metal-String Complexes with the Fine-tune of Unsymmetrical 2-phenylamino-7-(α-pyridylamino)-1,8-naphthyridine Ligand". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/6f4n7g.

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碩士<br>國立臺灣大學<br>化學研究所<br>104<br>The aim of this thesis is to modify the unsymmetrical H2phapany ligand, replacing the meta-position hydrogen atom of phenyl group. The fine-tuned ligand, H2phaphpany, was synthesized and used to synthesize new type of pentanickel metal-string complexes. Then we investigated their structural characterizations, magnetic properties, electrochemistry and UV spectra. By using different metal salt precursors with H2phaphpany ligand at high temperature, different isomeric forms of pentanickel complexes, (2,2)-trans[Ni5(μ5-phaphpany)4(NCS)2], (3,1)-[Ni5(μ5-phaphpany

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Huang, Gin-Chen. "Synthesis, Crystal Structures, Physical Properties and DFT Studies of a Series of Linear Asymmetric Hetero-Trinuclear Complexes and Metal Clusters with Naphthyridine-Functionalized Amide Ligands." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0807200814043500.

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Huang, Gin-Chen, and 黃俊程. "Synthesis, Crystal Structures, Physical Properties and DFT Studies of a Series of Linear Asymmetric Hetero-Trinuclear Complexes and Metal Clusters with Naphthyridine-Functionalized Amide Ligands." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/52237630365344253362.

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博士<br>國立臺灣大學<br>化學研究所<br>96<br>Our group was devoted to the research of metal string complexes. We believe that the thinnest metal wire may be applied to practical applications in the future. The dipyridylamide ligand (Hdpa) has been used to stabilize homo-trinuclear metal string complexes. A series of homo-trinuclear M3(dpa)4X2 complexes have been studied in detail in past decades. A new type of heterometallic framework, combining in a linear arrangement with a ruthenium dimer and a third metal atom, either Cu or Ni has been synthesized and studied thoroughly. The metal frameworks of Ru2Cu(dp

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Chen, Ting-Yu, and 陳庭郁. "Synthesis, Structures and the Photophysical Properties of Mono- and Dinuclear Platinum Complexes derived from C^C^C-Pincer Bis(carbene) Ligand with 1,8-naphthyridine and 7-azaindole coligands." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/49971686218366511864.

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Huang, Ju-Hui, and 黃如慧. "Part1:Development of Metal Ion Chemosensors by Using Naphthyridine Derivativespart2:Design and Synthesis of Water Soluble Carbohydrate ReceptorsPart3:The Second-Order Nonlinear Optical Properties of Thiophene Conjugated Heterocycles." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/82651054534434338761.

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博士<br>國立臺灣大學<br>化學研究所<br>92<br>Abstract This thesis consists of three parts. The first part is to develop metal ion chemosensors containing naphthyridine moiety; the second part is to design and synthesize water soluble carbohydrate receptors; the last part is to characterize the second-order nonlinear optical properties of thiophene conjugated heterocycles. Part I: Development of metal ion chemosensors containing naphthyridine moiety Up to now only a few chemosensors of heavy (transition) metal ions utilize fluorescence enhancement as the detection mechanism. Our research objective is to deve

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