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Relevant bibliographies by topics / Natural product; Nucleophiles; Stereochemistry

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Journal articles
Dissertations / Theses
Book chapters

Academic literature on the topic 'Natural product; Nucleophiles; Stereochemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Natural product; Nucleophiles; Stereochemistry"

1

Ding, Wei, Yongzhen Li, and Qi Zhang. "Substrate-Controlled Stereochemistry in Natural Product Biosynthesis." ACS Chemical Biology 10, no. 7 (2015): 1590–98. http://dx.doi.org/10.1021/acschembio.5b00104.

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Tait, Katrina, Alysia Horvath, Nicolas Blanchard, and William Tam. "Acid-catalyzed ring-opening reactions of a cyclopropanated 3-aza-2-oxabicyclo[2.2.1]hept-5-ene with alcohols." Beilstein Journal of Organic Chemistry 13 (December 27, 2017): 2888–94. http://dx.doi.org/10.3762/bjoc.13.281.

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The acid-catalyzed ring-opening reactions of a cyclopropanated 3-aza-2-oxabicylic alkene using alcohol nucleophiles were investigated. Although this acid-catalyzed ring-opening reaction did not cleave the cyclopropane unit as planned, this represent the first examples of ring-openings of cyclopropanated 3-aza-2-oxabicyclo[2.2.1]alkenes that lead to the cleavage of the C–O bond instead of the N–O bond. Different acid catalysts were tested and it was found that pyridinium toluenesulfonate in methanol gave the best yields in the ring-opening reactions. The scope of the reaction was successfully e

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Essig, Sebastian, and Dirk Menche. "Stereochemistry and total synthesis of complex myxobacterial macrolides." Pure and Applied Chemistry 85, no. 6 (2013): 1103–20. http://dx.doi.org/10.1351/pac-con-12-09-12.

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Polyketides are a very diverse family of natural products with an extremely broad range of biological activities and pharmacological properties, including antiproliferative, antibiotic, antifungal, or antiplasmodial activities, and in many cases specific targets are addressed at the molecular level. Their structures are characterized by diverse assemblies of methyl- and hydroxyl-bearing stereogenic centers enabling large numbers of stereochemical permutations, which are often embedded into macrolide rings. This complexity renders the stereochemical assignment and directed total synthesis chall

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Huo, Haohua, Bradley J. Gorsline, and Gregory C. Fu. "Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles." Science 367, no. 6477 (2020): 559–64. http://dx.doi.org/10.1126/science.aaz3855.

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Stereochemical control in the construction of carbon-carbon bonds between an alkyl electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis. Classical substitution reactions via SN1 and SN2 pathways are limited in their ability to generate carbon-carbon bonds (inadequate scope, due to side reactions such as rearrangements and eliminations) and to control stereochemistry when beginning with readily available racemic starting materials (racemic products). Here, we report a chiral nickel catalyst that couples racemic electrophiles (propargylic halides) with racemic nuc

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Suzuki, Keisuke. "Synthetic study of ravidomycin, a hybrid natural product." Pure and Applied Chemistry 72, no. 9 (2000): 1783–86. http://dx.doi.org/10.1351/pac200072091783.

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Strategies and tactics associated with the total synthesis of hybrid natural products are discussed. The target is ravidomycin (2), one of the gilvocarcin-class antitumor antibiotics with an aryl C-glycoside structure. The first total synthesis of 2, which was achieved along similar lines of that of gilvocarcin V (1), served for the determination of the relative as well as the absolute stereochemistry of 2. Also revealed was a limitation of the synthetic scheme so long as the amino sugar congener was concerned. A preliminary result is discussed on the [2+2+2] approach that relies on the ready

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Akula, Pavan Sudheer, Bor-Cherng Hong, and Gene-Hsiang Lee. "Visible-light-induced C(sp3)–H activation for a C–C bond forming reaction of 3,4-dihydroquinoxalin-2(1H)-one with nucleophiles using oxygen with a photoredox catalyst or under catalyst-free conditions." RSC Advances 8, no. 35 (2018): 19580–84. http://dx.doi.org/10.1039/c8ra03259a.

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A convenient photocatalyzed coupling reaction of 4-alkyl-3,4-dihydroquinoxalin-2(1H)-one with a variety of nucleophiles was developed with a household compact fluorescent light. The synthesis of natural product cephalandole A was also demonstrated.

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Hanessian, S., Roberto Margarita, Adrian Hall, Shawn Johnstone, M. Tremblay, and L. Parlanti. "New and old challenges in total synthesis. From concept to practice." Pure and Applied Chemistry 75, no. 2-3 (2003): 209–21. http://dx.doi.org/10.1351/pac200375020209.

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The total synthesis of dysinosin A, a novel member of the aeruginosin group of marine natural products is discussed. The stereocontrolled synthesis also confirms the proposed structure and absolute stereochemistry of the natural product.

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Barrett, Anthony G. M., Mark L. Boys, and Terri L. Boehm. "Total synthesis of (+)-papuamine: determination of the absolute stereochemistry of the natural product." Journal of the Chemical Society, Chemical Communications, no. 16 (1994): 1881. http://dx.doi.org/10.1039/c39940001881.

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Gupta, Vinayak, and Kate S. Carroll. "Rational design of reversible and irreversible cysteine sulfenic acid-targeted linear C-nucleophiles." Chemical Communications 52, no. 16 (2016): 3414–17. http://dx.doi.org/10.1039/c6cc00228e.

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We report the design of linear C-nucleophiles that react with sulfenic acid in a covalent, reversible manner. We further establish that linear C-nucleophile moieties present in the rheumatoid arthritis drug, tofacitinib and natural product, curcumin also form covalent adducts with sulfenic acid.

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Han, Feipeng, Yian Guo, and Tao Ye. "Total synthesis of antiallergic bicyclic peptide seongsanamide A." Organic Chemistry Frontiers 7, no. 13 (2020): 1658–62. http://dx.doi.org/10.1039/d0qo00531b.

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Dissertations / Theses on the topic "Natural product; Nucleophiles; Stereochemistry"

1

Christopher, John Andrew. "Alkylation of planar chiral cationic pi-allylmolybdenum complexes : the total synthesis of cryptophycin 4." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323420.

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Kreisberg, Jennifer Diane. "Studies directed towards the total synthesis of the natural product diazonamide A." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037513.

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Lolli, Riccardo. "Identification of natural product stereochemistry via calculation of ECD spectra." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29735.

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Most commercially available antibiotics are obtained from natural products, secondary metabolites of bacteria or other living organisms. Due to the importance of this class of compounds in medicinal chemistry and growing drug resistance, efforts to discover, characterize and isolate new or improved antibiotics are continually increasing. The assignment of the absolute configuration (AC) adopted by these compounds is a crucial aspect of the characterization step and knowledge of the stereochemistry is an important factor in deciphering the interaction of these compounds with the organism and th

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Beck, Daniel Antony Speedie. "Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses /." View thesis entry in Australian Digital Theses Program, 2006. http://thesis.anu.edu.au/public/adt-ANU20070130.130009/index.html.

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Sun, Han. "Stereochemistry of Challenging Natural Products Studied by NMR-based Methods." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-FD1A-F.

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Lo, Kar-yan. "Gold catalysis stereoselective synthesis of propargylamines and axially chiral allenes, and application on natural product modifications /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41758122.

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Restorp, Per. "Stereoselective Nucleophilic Additions to α-Amino Aldehydes: Application to Natural Product Synthesis". Doctoral thesis, KTH, Organisk kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4233.

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This thesis deals with the development and application of new synthetic methodology for stereo- or regioselective construction of carbon-carbon bonds in organic synthesis. The first part of this thesis describes the development of a divergent protocol for stereoselective synthesis of chiral aminodiols by employing Mukaiyama aldol additions to syn- and anti-α-amino-β-silyloxy aldehydes. The stereoselectivity of the nucleophilic attack is governed by either chelation to the α-amino moiety or by nucleophilic attack in the Felkin-Anh sense. This study is also directed towards the elucidation of th

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Book chapters on the topic "Natural product; Nucleophiles; Stereochemistry"

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Magriotis, Plato A. "Synthetic Approaches to the Stereochemically Complex Antitumor Drug Ecteinascidin-743: A Marine Natural Product by the Name Yondelis® or Trabectidin." In Stereochemistry and Global Connectivity: The Legacy of Ernest L. Eliel Volume 2. American Chemical Society, 2017. http://dx.doi.org/10.1021/bk-2017-1258.ch005.

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