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Journal articles on the topic 'Nigella sativa oil'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kafi, Lubna Ahmed. "The cytotoxic effect of olive oil, nigella sativa and their combination on Hela cancer cell line (in vitro)." Kufa Journal For Veterinary Medical Sciences 6, no. 2 (2015): 87–97. http://dx.doi.org/10.36326/kjvs/2015/v6i23996.

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This study was done to comparison among the cytotoxicity of olive oil, nigella sativa oil and the mixture of olive oil and nigella sativa oil on Hela cancer cell line, the results reveled to the maximum cytotoxic concentration of each olive oil and nigella sativa oil on Hela cancer cell line started from (1 µg/ml – 10000 µg/ml) at 72 hr. incubation periods, which reflect the pattern of cytotoxicity was time depending.While the result the mixture cytotoxicity shows an increasing in cytotoxicity occurred with increasing in the incubation periods especially at 72hr. at concentration equal to 1000

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2

Ananda, Siti Hadrayanti, and Narmawan Narmawan. "EFFECT OF NIGELLA SATIVA OIL ON BLOOD PRESSURE IN ADULTS WITH HYPERTENSION IN KENDARI INDONESIA." Public Health of Indonesia 6, no. 1 (2020): 14–17. http://dx.doi.org/10.36685/phi.v6i1.327.

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Background: Hypertension remains a big challenge for people in Indonesia, especially in adults. Therefore, an effort to reduce high blood pressure is needed. Nigella sativa or known as habbatussauda is one of herbs that is assumed to be able to reduce high blood pressure.Objective: This study aims to determine the effect of nigella sativa oil on blood pressure in hypertensive adults.Method: A quasi-experimental research design with pretest-posttest with control group design. A total of 60 respondents were selected using simple random sampling technique, which 30 were randomly assigned in an in

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M.Al-Janabi., Jasim, Mohammed S. Abdulla, and Aseel S. AL-Hindi. "STUDY OF THERAPEUTIC EFFECT OF BLACK SEED OILON HYPERLIPOPROTENIMA." Tikrit Journal of Pharmaceutical Sciences 2, no. 1 (2023): 26–30. http://dx.doi.org/10.25130/tjphs.2006.2.4.26.30.

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Hyperlipoproteiteinemia is well established as a major risk factor for cardiovascular diseases .. Lowering of serum liquids were found to be associated with tbe reduction in cardiovascular diseases .The aim of this study is to determine tbe effect of Nigel la sativa oil on the-serum lipids , Fasting blood glucose and w-ic acid in Hyperlipoproteinemia patients. Blood samples were taken from (30) patients suffer from Hyperlipoproteinemia and volunteered to take Nigella sativa oil .The blood samples from these groups were analyzed for measuring serum total choesterol triglycerides , phospholipids

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4

E. AI-Snafi, Ali, Abdul Ghani M. AI-Samarai, and Ahmed M. AI Sabawi. "The therapeutic effect of Nigel/a sativa seed oil in treatment of chronic urticaria." Tikrit Journal of Pharmaceutical Sciences 1, no. 1 (2023): 1–6. http://dx.doi.org/10.25130/tjphs.2005.1.1.1.6.

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Urticaria is a common disease which affects an approximately 15-25% of the population at some point during their life time. Chronic urticaria indicates the presence of hives for a protracted period (>6weeks). Antihistamines, steroids and immune suppressants are needed for the treatment of chronic miicaric. This study was designed to investigate the therapeutic effects of Nigella sative oil in the treatment of chronic urticaria. The results showed that 400 mg twice daily of Nigella sativa oil (in gelatin capsule) was significantly increase cure rate. It also significantly decreases log1 o Ig

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Murtuza, Bohra, Patel Poonam, Dighe Kamayani, Ali Khan Rahat, and Ahmed Khan Aijaz. "Nephroprotective Role of Nigella Sativa Oil Against Gentamicin Induced Nephrotoxicity: An Experimental Study in Rats." International Journal of Toxicological and Pharmacological Research 12, no. 6 (2022): 91–101. https://doi.org/10.5281/zenodo.11658986.

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The objective of this study is to evaluate the nephroprotective activity and antioxidant potential of <em>Nigella sativa oil</em> against Gentamicin-induced nephrotoxicity. Healthy adult albino rats of either sex (100-200 g) was randomly divided into six groups of five animals each. Group I (normal control) were administered distilled water intra peritoneally for 8 days. Group II (LNSO). were administered low dose nigella sativa oil 1ml/kg orally for 10 days. Group III (HNSO) were administered High dose nigella sativa oil 2ml/kg orally for 10 days. Group IV (GNCG)Gentamicin negative

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Rahmadhani, Wulan, Nisfatul Annisa, and Suci Amin. "PENERAPAN PEMBERIAN MINYAK JINTAN HITAM (NIGELLA SATIVA OIL) UNTUK PENGOBATAN BIANG KERINGAT (MILIARIA) PADA BAYI DI WILAYAH PMB BRIDA KITY DINARUM S.ST." Al-Insyirah Midwifery: Jurnal Ilmu Kebidanan (Journal of Midwifery Sciences) 10, no. 2 (2021): 75–80. http://dx.doi.org/10.35328/kebidanan.v10i2.2071.

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Latar belakang: Perubahan iklim dan suhu dapat menimbulkan biang keringat (miliaria) pada bayi. Biang keringat adalah ruam kecil yang terasa gatal menyebabkan iritasi kulit. Hal ini dapat diatasi dengan tanaman obat yaitu minyak jintan hitam (Nigella sativa oil) yang berfungsi untuk menghentikan inflamasi atau peradangan. Tujuan: Untuk mengetahui pemberian minyak jintan hitam (Nigella sativa oil) sebagai pengobatan biang keringat (miliaria) pada Bayi. Metode: Karya Tulis Ilmiah ini merupakan jenis penelitian studi kasus. Data diperoleh dari wawancara, observasi atau pengamatan dan

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7

Murtuza, Bohra, Dighe Kamayani, Patel Poonam, Ali Kha Rahat, and Ahmed Khan Aijaz. "Amelioration of Amikacin Induced Nephrotoxicity by Nigella Sativa Oil: An in Vivo Study in Rats." International Journal of Toxicological and Pharmacological Research 12, no. 5 (2022): 148–56. https://doi.org/10.5281/zenodo.11827049.

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The objective of this study is to evaluate the nephroprotective role and antioxidant effects of <em>Nigella sativa oil</em> against Amikacin-induced nephrotoxicity in rats.We divide Healthy adult albino rats of either sex (100-200 g) randomly and equally into six groups of five animals each. Group I animals (normal control) were administered distilled water intra peritoneally for 14 days. Group II animals (LNSO) were administered low dose nigella sativa oil 1ml/kg orally for 16 days. Group III animals (HNSO) were administered High dose nigella sativa oil 2ml/kg orally for 16 days. Gr

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8

Perinelli, Diego Romano, Elisabetta Torregiani, Giulia Bonacucina, Marco Cespi, Giovanni Filippo Palmieri, and Rosita Gabbianelli. "Antioxidant Properties of Ester Derivatives of Cinnamic and Hydroxycinnamic Acids in Nigella sativa and Extra-Virgin Olive Oils-Based Emulsions." Antioxidants 11, no. 2 (2022): 194. http://dx.doi.org/10.3390/antiox11020194.

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New hydrophobic derivatives of cinnamic and hydroxycinnamic (ferulic and cumaric) acids obtained by chemical esterification of the carboxylic group with C10 linear alcohol were studied to evaluate their antioxidant capacity toward the superoxide anion and hydrogen peroxide in physiological buffer and in extra-virgin olive oil (EVO) or Nigella sativa oils. Results showed that cumaric and ferulic acids have higher antioxidants activity against superoxide anion and hydrogen peroxide than the other compounds. Cumaric acid and its C10-ester derivative were selected to be incorporated into EVO or Ni

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9

BURIRO, MUHAMMAD ANWAR, MUHAMMAD TAYYAB, and ALLAH DTTTA. "EFFECTS OF NIGELLA SATIVA AND SUNFLOWER OIL DIET ON WEIGHT OF ALBINO RATS." Professional Medical Journal 18, no. 03 (2011): 530–34. http://dx.doi.org/10.29309/tpmj/2011.18.03.2388.

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Objective: To study the effects of nigella sativa and sunflower oil on weight of albino rats. Study Design: Experimental study. Period: 1996 to 1997. Setting: PGMI, Lahore. Material & Methods: A study was conducted to determine the effects of nigella sativa and sunflower oil diet intake on body weight in albino rats. Fifty six albino rats with equal number of males and females were selected for the study, they were divided into four different groups, Control groups I and III were given diet (20%), high fat diet supplemented with bile salt (1% colic acid) and antithyroid drug (0.5% propylth

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10

Nikolova, N. S., та S. I. Danyliv. "Analysis of fatty oil Nigella sativa l. рroduced in Ukraine and Bulgaria". BULLETIN OF MEDICAL AND BIOLOGICAL RESEARCH 4, № 1 (2022): 80–83. http://dx.doi.org/10.11603/bmbr.2706-6290.2022.1.12831.

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Summary. The article presents the results of the study of the fatty acid spectrum of Nigella sativa L. seed oil grown in different geographical regions – Ukraine and Bulgaria. The task of studying the rich chemical composition of the plant due to the wide range of its pharmacological action remains relevant. The aim of the study – comparative study of the fatty acid composition of Nigella sativa L. seed oils grown in different geographical and climatic regions. Materials and Methods. Nigella sativa L. oil samples were obtained from 2 different geographically remote regions, Ukraine and Bulgari

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Dwita, Lusi, Kori Yati, and Sri Gantini. "The Anti-Inflammatory Activity of Nigella sativa Balm Sticks." Scientia Pharmaceutica 87, no. 1 (2019): 3. http://dx.doi.org/10.3390/scipharm87010003.

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Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on

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Syahputra, Igor Rizkia, and Eka Yudhanto. "Molecular Mechanisms of Ozonized Nigella sativa Oil in Wound Repair: Albumin as Biomarker in Rat Model." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 11 (2024): 5476–88. http://dx.doi.org/10.37275/bsm.v8i11.1128.

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Background: Wound healing is a complex physiological process that can be impaired in various conditions. Nigella sativa oil, rich in bioactive compounds like thymoquinone, has shown promise in promoting wound healing. Ozone therapy, through the generation of reactive oxygen species (ROS), has also been explored for its potential to accelerate wound repair. This study aimed to investigate the molecular mechanisms underlying the effects of ozonized Nigella sativa oil on wound healing, with a focus on albumin as a biomarker of tissue regeneration in a rat model. Methods: Full-thickness skin wound

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Akgul, Mehmet Huseyin, Mehmet Yigit Akgun, Tugce Anteplioglu, and Oguz Kul. "The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study." Ideggyógyászati szemle 76, no. 11-12 (2023): 379–84. http://dx.doi.org/10.18071/isz.76.0379.

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Background and purpose – Epidural fibrosis after all spinal surgeries is an important surgical issue. Various biological and non-biological materials have been tried to inhibit epidural fibrosis, which is deemed to be the most important cause of pain after spinal surgery. Olive oil, nigella sativa oil and soybean oil employed in oral nutrition in clinics involving liquid fatty acids, palmatic acid, linoleic acid, stearic acid and palmitoleic acid. The effectiveness of olive oil, nigella sativa oil and soybean oil on epidural fibrosis was researched on for the first time in laminectomy model. M

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14

Murtuza, Bohra, Ram Kishna, Vishwe Akash, Malani Richa, and Riaz Rabia. "A Comparative Experimental Study to Evaluate Nephroprotective Effects of Nigella Sativa Oil in Gentamicin and Kanamycin Induced Nephrotoxicity in Rats." International Journal of Toxicological and Pharmacological Research 14, no. 8 (2024): 15–25. https://doi.org/10.5281/zenodo.13759366.

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<strong>Background:</strong> Very frequently Drug-induced toxicity occurs in the kidney. Renal uptake, renal accumulation, and renal biotransformation of drugs could contribute to this susceptibility of kidneys to toxic damage. Aminoglycosides are often indicated in treatment of infections caused by aerobic gram-negative bacteria and resistant mycobacteria causing drug resistant TB. Nephrotoxicity is one of the most important side effects and therapeutical limitations of these antibiotics, especially gentamicin and kanamycin. Traditional medicinal plants and their products like nigella sa

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15

Alayunt, Naci Omer, Yasemin Kayaoglu, Musa Yilmaz, and Bilal Ustundag. "Nigella Sativa Oil Improves Oxidative Stress, Inflammation and Changes in Neurotransmitter Structures in Fructose-Induced Metabolic Syndrome." Euroasia Journal of Mathematics, Engineering, Natural & Medical Science 10, no. 29 (2023): 128–38. https://doi.org/10.5281/zenodo.8416168.

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Metabolic syndrome (MetS) causes inflammation in adipose tissue along with oxidative stress and cellular damage. We aimed to investigate the protective effects and biochemical mechanisms of nigella sativa oil on MetS caused by excessive fructose intake in rats. 21 male Sprague-Dawley rats were used in the study. Rats; were divided into groups as control group, metabolic syndrome group and nigella sativa oil group. While the rats in the control group were fed only tap water and pellet food, the rats in the experimental group were fed with tap water with 10% fructose and pelleted diet for 10 wee

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Rico Sentosa Sihombing and Rena Meutia. "Optimasi Formulasi Krim Minyak Jintan Hitam (Nigella Sativa Linn) Dengan Variasi Konsentrasi Asam Stearat Dan Trietanolamin." Jurnal Ventilator 1, no. 3 (2023): 01–09. http://dx.doi.org/10.59680/ventilator.v1i3.434.

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Black cumin oil (Nigella Sativa Linn) is rich in antioxidants. One of the substances contained in black cumin oil (Nigella Sativa Linn) which acts as an antioxidant is thermoquinone. Cream is a widely chosen preparation because it is one of the pharmaceutical preparations that is used topically for the treatment of various skin diseases. The purpose of this study was to determine whether Cumin (Nigella Sativa Linn) Oil (Nigella Sativa Linn) can be formulated as a cream dosage form. to find out the optimum concentration of black cumin oil cream formulation (Nigella Sativa Linn) with cream base

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Murtuza, Bohra, Vishwe Akash, Gour Pushpraj, Malani Richa, Rajak Preeti, and Riaz Rabia. "Evaluation of Nephroprotective Potential of Nigella sativa Oil against Kanamycin Induced Nephrotoxicity in Rats." International Journal of Toxicological and Pharmacological Research 14, no. 8 (2024): 105–9. https://doi.org/10.5281/zenodo.13856025.

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The objective of this study is to evaluate the nephroprotective role of <em>Nigella sativa oil</em> against Kanamycin-induced nephrotoxicity in rats. The nephroprotective potential was evaluated on basis histopathological changes in renal tissue. Healthy adult albino rats of either sex (100-200 g) were randomly and equally into six groups of five animals each. Group I animals (normal control: DWNC) were administered distilled water intra peritoneally for 14 days. Group II animals (LNSO) were administered low dose nigella sativa oil 1ml/kg orally for 16 days. Group III animals (HNSO)

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Hassan, Ghazala, Sarah Ghafoor, Saima Chaudhry, and Zubair Ahmed Khan. "Salivary Interleukin-1 Levels in Chronic Periodontitis Patients after use of Nigella Sativa (Kalonji) Oil." Journal of the Pakistan Dental Association 29, no. 04 (2020): 205–10. http://dx.doi.org/10.25301/jpda.294.205.

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OBJECTIVE: Periodontitis is the second most prevalent microbiome associated inflammatory disease posing a threat to oral health. Nigella sativa (Kalonji) has been used since ancient times as a remedy for oral inflammatory conditions. Interleukin1 (IL-1 ) is critical for periodontal inflammation, collagen degradation and bone turn over. The motive of our study was to determine the change in the levels of salivary IL-1 after the use of Nigella sativa oil to determine if it has any correlation with salivary IL-1 . METHODOLOGY: A parallel-arm triple-blind placebo-based randomized control trial was

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Pal, Dipali Rani, Shamusn Nahar, Kanta Roy, et al. "Hepatoprotective Effect of Nigella Sativa Linn (Kalajira) On Paracetamol-induced Liver Damage." Bangladesh Medical Journal 40, no. 3 (2014): 52–54. http://dx.doi.org/10.3329/bmj.v40i3.18677.

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Paracetamol is the widely used non-steroidal anti-inflammatory drugs for the treatment of mild to moderate pain. It causes hepatotoxicity in therapeutic dose for prolonged time. It can induce centrilobular hepatic necrosis in large over doses. Nigella sativa (kalajira) is a medicinal plant has a protective role against hepatotoxicity. Therefore, the present study was designed to observe the protective role of Nigella sativa on paracetamol induced liver damage biochemically in Long Evans rats. The experiment was carried out in the Department of Anatomy, Dhaka Medical college, in the period of J

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Morteza, Salarzaei Mahmood Anbari Fateme Parooei*. "PHYSIOLOGICAL EFFECTS OF NIGELLA SATIVA ON BODY-A REVIEW." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 2890–92. https://doi.org/10.5281/zenodo.889523.

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Introduction: Nigella Sativa has a lot of healing properties, such as improving inflammatory, diabetes, cardiovascular, renal and liver diseases. Chemical compounds of back cumin include fixed oils [35-40%], volatile oils [-0.05%], proteins [23%], Various amino acids, sugars, mucilages, alkaloids, organic acids, tannins, resins, lipases, phytosterols, vitamins, and various types of minerals; seeds such as timolol thymoquinone and di-thymico-quinone are derived from ferrous oil of Nigella Sativa. Methods: In this review article, the databases Medline, Cochrane, Science Direct, and Google Schola

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Nasuti, Cinzia, Donatella Fedeli, Laura Bordoni, et al. "Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis." Antioxidants 8, no. 9 (2019): 342. http://dx.doi.org/10.3390/antiox8090342.

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This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). Nigella sativa oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin

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Micheal Olatunji Avoeseh, Musa Alabi Okunola, and Akinosho Aalimah Akorede. "Nigella sativa oil mitigate paraquat-induced neurobehavioural, oxidative and histological alterations in the cerebellum of adult male wistar rat." International Medical Science Research Journal 4, no. 9 (2024): 882–91. http://dx.doi.org/10.51594/imsrj.v4i9.1597.

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Over the past few decades, several cases of poisoning and death resulting from environmental exposure to the herbicide, paraquat (PQ), has been reported. However, nigella sativa oil, with several antioxidants and anti-inflammatory properties present a significant tool against PQ-induced toxicity. Thus, the study aim was to assess the possible mitigative effect of nigella sativa oil administration on paraquat-induced neurotoxicity in the cerebellum. Twenty-eight (28) adult Wistar rats were randomly divided into four groups of seven (7) rats each. Group I (control) received 0.3ml of normal salin

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Gürel, Şirin Hatice, and Derya Çiçek Polat. "NIGELLA SATIVA L.: AN OVERVIEW." Ankara Universitesi Eczacilik Fakultesi Dergisi 49, no. 1 (2024): 21. https://doi.org/10.33483/jfpau.1504025.

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Objective: Nigella sativa L. (Ranunculaceae) is an annual herbaceous plant indigenous to the Mediterranean region and Western Asia globally. It is cultivated in Türkiye, especially in Isparta, Burdur and Afyonkarahisar. While its seeds are known for their characteristic black color in many languages, in Türkiye, it is recognized as "çörek otu". Traditionally, its seeds have been utilized for addressing rheumatism, bronchitis, colds, asthma and inflammatory conditions, as well as to enhance milk production in lactating mothers, aid digestion, and combat parasitic infections. Meanwhile, its oil

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Najmi, A., S. F. Haque, M. Naseeruddin, and R. A. Khan. "Effect of Nigella Sativa oil on various clinical and biochemical parameters of metabolic syndrome." International Journal of Diabetes and Metabolism 16, no. 2 (2008): 85–87. http://dx.doi.org/10.1159/000497657.

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Background: The seeds of Nigella sativa plant have been used to promote health and fight disease for centuries especially in the Middle East and Southeast Asia. This plant has been a great focus of research. This clinical study was undertaken to determine the adjuvant effect of Nigella sativa oil on various clinical and biochemical parameters of the metabolic syndrome. Methodology: This prospective study was conducted at a tertiary health care centre in North India. After final diagnosis and considering inclusion and exclusion criteria, sixty patients were enrolled in this study. Informed and

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MohammedAmeen, Hazha Abdullah, Mohammed Omer Mohammed, Rebaz HamaGareb Ali, Khadija Muhamed Ahmed, and Saad Abdulrahman Hussain. "Nigella Sativa Oil for Oral Mucositis." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 3 (2019): 54–67. http://dx.doi.org/10.32947/ajps.v19i3.625.

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Oral mucositis (OM) is common treatment-induced toxicity in patients receiving chemoradiation for head and neck cancer (HNC). The present study aims to evaluate the efficacy and safety of Nigella sativa (NS) oil in chemoradiation-induced OM of HNC patients. From  January 2017 to May 2018, 40 patients with HNC were randomly allocated into two groups each of 20 patients. The first group received NS oil mouthwash five times daily, while the second group received the routinely followed protocol (magic mouthwash) and served as a control. All patients received radiotherapy (RT) (60-70 Gy

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Hamad, Zena M. "Protective role of Nigella sativa oil on renal damage induced by acetaminophen in male rats." Iraqi Journal of Veterinary Medicine 40, no. 2 (2017): 77–81. http://dx.doi.org/10.30539/iraqijvm.v40i2.116.

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Acetaminophen also called paracetamol is commonly used as analgesic and antipyretic agent which in high doses causes liver and kidney damage in man and animals. Nigella sativa oil have antioxidant properties. Thirty adult male rats were used and randomly divided into three equal groups. Group (A) untreated and served as control group; Group (B) rats were orally intubated (by gavages needle) acetaminophen suspension (150mg/kg B.W). Group (C) rats were given orally acetaminophen suspension (150mg/kg) plus 1ml/kg B.W of Nigella sativa oil for 42 days in both treated group. Fasting blood samples w

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Czajkowska, Anna, Agnieszka Gornowicz, Natalia Pawłowska, et al. "Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells." BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/9153403.

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Many studies have shown that naturally occurring compounds may support prevention and treatment of various diseases, including cancer. Pharmacological investigations revealed a wide spectrum of Nigella sativa biological activities. Combining natural compounds together with synthetic drugs may increase the anticancer activity and limit severe side effects of such a treatment and may be an alternative to monotherapy. The aim of the study was to evaluate the cytotoxic and proapoptotic effects of a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative and its effect in combination with Ni

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Guergouri, Fatima Zohra, and Widad Sobhi. "Evaluation of the protective effect of Nigella sativa oil’s unsaponifiable fraction in carbon tetrachloride-kidney damage model." Journal of Drug Delivery and Therapeutics 14, no. 10 (2024): 18–23. http://dx.doi.org/10.22270/jddt.v14i10.6821.

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Background/Aim: Kidney diseases is a global public health problem. This study was conducted to evaluate the renoprotective effect of the total oil’s unsaponifiable fraction (UF) of a medicinal plant called Nigella sativa. Methods: The extraction of unsaponifiables from the total seed oil of the medicinal plant Nigella sativa was carried out according to the standardized methods of the European Pharmacopoeia (Edition 5.0). Carbon tetrachloride (CCl4) is known to induce kidney toxicity. Acute poisoning of Male albino rats with 1:1 (v/v) mixture of CCl4 and olive oil (3 ml/Kg b.w. of rat by subcu

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Mardhiah. "The Effect of Nigella sativa Oil to Prevent Decubitus among Bedrest Patients." Caring: Indonesian Journal of Nursing Science 3, no. 1 (2021): 57–67. http://dx.doi.org/10.32734/ijns.v3i1.6242.

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Using Nigella sativa oil for skin care is a nursing measure to maintain skin integrity to prevent further tissue damage. The oil contains thymoquinone (27.8%-57%), which has been tested to heal a wound, acting as a potent analgesic and anti-inflammatory. Linoleic acid (57.9%) and linolenic acid (0.2%) act as cell-forming substances and helping to moisturize the skin. This study aims to discover the effect of Nigella sativa oil, which is applied to prolonged bedridden patients with the risk of decubitus. This study used a quasi-experimental design with one group pretest-posttest design. Random

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Wael, Syahran, Didik Wahyudi, Tayeb Wael, and Zaid Mohamed Jaber. "The effect of black cumin oil (Nigella sativa) on the reproduction of male Wistar rats." BIOEDUPAT: Pattimura Journal of Biology and Learning 1, no. 2 (2021): 45–49. http://dx.doi.org/10.30598/bioedupat.v1.i2.pp45-49.

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Nigella sativa oil is antioxidant compound has the effect that serves to prevent cellular damage. The effect of Nigella sativa oil in the motility and total count of spermatozoa wistar rats. Experimental research with the design of post test only control group design. Wistar rats consists of 24 head and divided into 4 groups consist of control and treatment group. The control group was distilled. The first treatment was of Nigella sativa oil everydays as much with dose 150 mg/kgbw, 250 mg/kgbw, and 350 mg/kgbw, for 16 days, . Statistic test for motility and count of sperm wistar rats use the K

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Nayyab Khattak, Noman Ullah Wazir, Mohammad Saeed, Ayesha Iftikhar, Rabbia Jabbar, and Muhammad Saleh Faisal. "The hepatoprotective potential of nigella sativa oil against cypermethrin-induced hepatotoxicity in rats: A histomorphological investigation." Professional Medical Journal 31, no. 08 (2024): 1140–46. http://dx.doi.org/10.29309/tpmj/2024.31.08.8193.

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Objective: To determine the hepatotoxic effects induced by cypermethrin. The study also attempts to evaluate the hepatoprotective efficacy of Nigella sativa oil against hepatotoxicity produced by cypermethrin. Study Design: Experimental study. Setting: Department of Anatomy, Pharmacology, and Pathology of Peshawar Medical College and Animal house of PCSIR Laboratories Complex, Peshawar. Period: May 2023 to Dec 2023. Methods: Animals were divided into two groups: Control (Group A) and Experimental (Group B). The Experimental group (Group B) is divided into two subgroups Group B-I and Group B-II

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Basurra, Rasha Saleh, Seok Mui Wang, and Mohammed Abdelfatah Alhoot. "Nigella sativa (Black Seed) as a Natural Remedy against Viruses." Journal of Pure and Applied Microbiology 15, no. 1 (2021): 29–41. http://dx.doi.org/10.22207/jpam.15.1.26.

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The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called Black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil & bioactive compounds). The findings reveal that numerous articles have

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Al- Ebady, Z. A. H. "Evaluation of the inhibitory effect of a number of medicinal plants fixed oils on a group of pathogenic bacteria invitro." Al-Qadisiyah Journal of Veterinary Medicine Sciences 10, no. 1 (2011): 36. http://dx.doi.org/10.29079/vol10iss1art141.

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The present study was designed to evaluate the antibacterial effect of 4 of local medicinal plants oils :Eletteria cardaomum,Nigella sativa,Prunus dulcisvar and Brassica alba in addition to 5 Antibiotics: Ciprofloxacin ,Chloramphenicol, Aztereonam, Sulfamethaxazole /Trimethoprime and Erythromycine as a positive control against 7 gram positive and gram negative pathogenic bacteria:Micrococcus spp.,Staphylococcus cohnii cohnii ,Enterobacter cloacae,Escherichia coli, Proteus mirabilis,Pseudomonas aeroginosa and Klebsiella pneumonia by using of agar well diffusion method . The result showed that f

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Hassan, Ghazala, Sarah Ghafoor, Saima Chaudhry, and Zubair Ahmed Khan. "Effect of Nigella Sattiva (Kalonji) Oil Based Mouth Wash on Salivary Matrix Metalloproteinase-8 Level in Patients with Chronic Periodonititis- A Randomized controlled Trial." BioMedica 36, no. 3 (2020): 285–90. http://dx.doi.org/10.24911/biomedica/5-112.

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<p><strong>Background and Objective</strong>: Salivary level of Matrix metalloproteinase-8 (MMP-8), a collagen degradation enzyme, is known to increase during chronic periodontitis. Nigella sativa is one of the potent anti[1]inflammatory compounds that has a promising role in oral inflammatory conditions. Present study aims to explore the salivary MMP-8 levels after Nigella sativa oil-based mouth wash as compared to placebo(normal saline) after non-surgical periodontal therapy in patients with chronic periodontitis.</p> <p><strong>Methods:</strong&g

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Mashayekhi-Sardoo, Habibeh, Ramin Rezaee, and Gholamreza Karimi. "Nigella sativa (black seed) safety: an overview." Asian Biomedicine 14, no. 4 (2020): 127–37. http://dx.doi.org/10.1515/abm-2020-0020.

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AbstractNigella sativa (commonly known as black seed or black cumin), from the family Ranunculaceae, is a plant that grows in countries bordering the Mediterranean Sea. This narrative review discusses the toxicological profile reported by short- to long-term studies that examined different extracts and oils of N. sativa seeds. Scientific databases including Web of Science, PubMed, Scopus, and Google Scholar were searched using appropriate keywords. LD50 for administered N. sativa seed fixed oil varied from 28.8 mL/kg to 3,371 mg/kg in mice, while 21 g/kg of aqueous, methanol, and chloroform ex

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NEMTINOV, V. I., Y. N. KOSTANCHUK, S. M. MOTYLEVA, et al. "MORPHOMETRIC AND BIOCHEMICAL ASSESSMENT OF NIGELLA L. GENOTYPES OF EUROPEAN-ASIAN ORIGIN." SABRAO Journal of Breeding and Genetics 54, no. 3 (2022): 659–70. http://dx.doi.org/10.54910/sabrao2022.54.3.18.

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A recent study in 2019-2020 assessed the productivity, the quality of fatty and essential oils, and the mineral composition of eight nigella genotypes at the Federal State Budget Scientific Institution (FSBSI), Research Institute of Agriculture of Crimea, Simferopol, Russia. Of the eight genotypes, two cultivars originated from Crimea, Russia (Nigella sativa cv. ‘Krymchanka,’ and Nigella damascena cv. ‘Yalita’), and one each from six European-Asian countries, i.e., Dagestan, Uzbekistan, and Sweden (Nigella sativa), Pakistan and India (Nigella indica), and Belgium (Nigella damascena). The Russi

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Isopencu, Gabriela, Mirela Marfa, Iuliana Jipa, et al. "Optimisation of the Oil Extraction from Nigella sativa Seeds Using Response Surface Methodology." Revista de Chimie 68, no. 2 (2017): 331–36. http://dx.doi.org/10.37358/rc.17.2.5447.

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Nigella sativa, also known as black cumin, an annual herbaceous plant growing especially in Mediterranean countries, has recently gained considerable interest not only for its use as spice and condiment but also for its healthy properties of the fixed and essential oil and its potential as a biofuel. Nigella sativa seeds fixed oil, due to its high content in linoleic acid followed by oleic and palmitic acid, could be beneficial to human health. The objective of this study is to determine the optimum conditions for the solvent extraction of Nigella sativa seeds fixed oil using a three-level, th

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Rana, M. Azmat, M. Nadeem Arshad, Salman Shafi Siddiqui, and M. Nasiruddin. "Study of effect of Nigella sativa on prevention of nephrotoxicity induced by colistin in experimental animals." International Journal of Basic & Clinical Pharmacology 8, no. 2 (2019): 306. http://dx.doi.org/10.18203/2319-2003.ijbcp20190151.

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ABSTRACTBackground: Nigella sativa, a widely used medicinal plant throughout the world belongs to family ranunculaceae. Its Seeds and oil have a long history of folklore usage in various traditional systems of medicines and food. This study was performed to evaluate the protective effect of Nigella sativa oil (NSO) on kidney when simultaneously given with colistin sulfate (CS) which induces tubular damage in rats.Methods: Animals were treated for 7 days: Group I (n=6) with normal saline and CMC, Group II, III and IV with 300.000IU/kg/day of CS (n=6). Group III and Group IV with NSO at the dose

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Khan, Zafar Ali, Namdeo Prabhu, Naseer Ahmed, et al. "A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial." International Journal of Clinical Practice 2022 (February 28, 2022): 1–8. http://dx.doi.org/10.1155/2022/7756226.

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Introduction. Alveolar osteitis (AO) is the most common complication faced by exodontia patients and is usually seen 24–74 hours after tooth extraction, heralded by severe throbbing pain. Nigella sativa is commonly known as black seed known to have anti-inflammatory and antibacterial properties along with other reparative properties that enhance bone formation. This study aimed to evaluate and compare the effects of Alvogyl and a mixture of Nigella sativa powder and oil in the treatment of dry sockets. Materials and Methods. Sixty patients above the age of 18 and below 70 years, from both gend

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Uma Maheswari, Karmegam. "A review on hypo-cholesterolemic activity of Nigella sativa seeds and its extracts." Bioinformation 18, no. 4 (2022): 343–48. http://dx.doi.org/10.6026/97320630018343.

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Nigella sativa (N. sativa) (Family Ranunculaceae) is a popular therapeutic herb in many parts of the world. It is widely used in traditional medical systems such as Unani, Ayurveda and Siddha. Seeds and oil have a long history of folkloric use in many medicinal and culinary systems. The seeds of N. sativa have long been used to treat a variety of illnesses and disorders. Studies on N. sativa and its therapeutic potential have been investigated. This includes anti-diabetic, anticancer, immune-modulatory, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective

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Al-Gharawi, Jassim Kassim, and Radhi Ajel Menshid Al-Zayadi. "Effect of Different Methods of Using Black Seed (Nigella sativa L.) to the Diet and Drinking Water on Qualitative Egg Traits of Laying Hens Eggs." IOP Conference Series: Earth and Environmental Science 1262, no. 7 (2023): 072029. http://dx.doi.org/10.1088/1755-1315/1262/7/072029.

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Abstract Research on the effect of adding powder, oil, aqueous, and alcoholic solutions of black seed (Nigella sativa), individually, on qualitative egg traits of laying hens eggs was conducted at the Agricultural Research and Experiment Station, Agriculture College, Al-Muthanna University from October 15, 2022, to January 7, 2023. There were a total of 75 laying hens (ISA Brown) employed, and they were all split up into 15 groups of 5. Each treatment’s pens were 3 by 3 metres in size, and the pens were divided into thirds such that each third held 5 hens. These are the methods of treatment: T

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Burits, M., and F. Bucar. "Antioxidant activity of Nigella sativa essential oil." Phytotherapy Research 14, no. 5 (2000): 323–28. http://dx.doi.org/10.1002/1099-1573(200008)14:5<323::aid-ptr621>3.0.co;2-q.

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Menounos, Panagiotis, Kostis Staphylakis, and Dina Gegiou. "The sterols of Nigella sativa seed oil." Phytochemistry 25, no. 3 (1986): 761–63. http://dx.doi.org/10.1016/0031-9422(86)88046-3.

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Hassan, Ghazala, Sarah Ghafoor, Saira Atif, Saima Chaudhry, and Zubair Ahmed Khan. "Non-Surgical Periodontal Therapy Improves Clinical Outcomes in Patients with Chronic Periodontitis Independent of the Use of Nigella Sativa Oil or Normal Saline Mouthwash; Randomized Controlled Trial." Journal of the Pakistan Dental Association 30, no. 02 (2021): 81–86. http://dx.doi.org/10.25301/jpda.302.81.

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OBJECTIVES: Chronic periodontitis (CP) is an inflammatory disease of microbial origin that harms the health of the oral tissues. The objective of this study was to analyze the effects of Nigella sativa oil mouthwash given for two weeks after non-surgical therapy in patients with CP. METHODOLOGY: This study was a parallel-arm randomized controlled trial that was conducted after ethical approval and registered with clinicaltrials.gov. The trial followed the guidelines of CONSORT and triple blinding was ensured. A total of fifty voluntary participants, after giving consent and being evaluated for

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Abdou, Nasr M., Mohamed H. H. Roby, Arwa Abdulkreem AL-Huqail, et al. "Compost Improving Morphophysiological and Biochemical Traits, Seed Yield, and Oil Quality of Nigella sativa under Drought Stress." Agronomy 13, no. 4 (2023): 1147. http://dx.doi.org/10.3390/agronomy13041147.

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This study aimed to determine the effects of compost amendment on the soil properties, as well as the morphophysiological responses, seed yield, oil content, and fatty-acid profile. of Nigella sativa plants under drought stress conditions. In a split-plot design, the field experiment was carried out during two seasons (2020/2021 and 2021/2022), involving three irrigation regimes (named I100, I75, and I50 of crop evapotranspiration) with three levels of compost application (C0, C15, and C30). Soil porosity, permeability, pore geometry, water-holding capacity, organic content, and soil cation ex

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Abdali, Dr Samara M. "Topical Nigella Sativa in the treatment of oro-genital ulceration in Behcet's disease." Mustansiria Dental Journal 6, no. 4 (2018): 366–70. http://dx.doi.org/10.32828/mdj.v6i4.487.

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To assess the effect of Nigella sativa oil as a topical preparation for treatment of oro- genital ulceration of Behcet's disease. This is a double blinded therapeutic trial in which 40 patients with Behcet's disease manifested as recurrent episodes of oral and genital ulceration were enrolled into 2 groups; Nigella sativa oil was applied as 10% in glycerin topically 3 times / daily to the first 20 patients. The other 20 were given glycerin only. Assessment was done 4 days then 8 days after treatment.Results were recorded as they appeared in clinical examination and those records were arranged

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Y, Ravi, Irene Vethamoni Periyanadar, Shailendra Nath Saxena, et al. "Identification, validation and quantification of thymoquinone in conjunction with assessment of bioactive possessions and GC-MS profiling of pharmaceutically valuable crop Nigella (Nigella sativa L.) varieties." PeerJ 12 (March 29, 2024): e17177. http://dx.doi.org/10.7717/peerj.17177.

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Background Plants have been pivotal in traditional and modern medicine globally, with historical evidence supporting their therapeutic applications. Nigella (Nigella sativa L.) is an annual herbaceous plant of the Ranunculaceae family and is cultivated in the Middle East, Eastern Europe, and Western and Central Asia. The medicinal use of plants dates back thousands of years, documented in ancient writings from various civilizations. Alkaloids, phenolics, saponins, flavonoids, terpenoids, anthraquinones, and tannins found in plants exhibit antioxidant, immunomodulatory, anti-inflammatory, antic

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M., Shnrwe B., and R. M. Ahmed. "RESPONSE OF YIELD AND CHEMICAL COMPOSITION OF BLACK CUMIN TO DIFFERENT FERTILIZER IN SULAIMANI REGION." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 53, no. 4 (2022): 901–10. http://dx.doi.org/10.36103/ijas.v53i4.1602.

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Two field experiment were conducted to evaluate the effect of different fertilizer on seed yield and oil content of two Black cumin species (Nigella sativa and Nigella arvensis), the first experiment was conducted at Qlyasan Agricultural Research Qlyasan Agricultural Research Station, College of Agricultural Engineering Sciences, University of Sulaimani, and the second experiment was conducted at Kanipanka Research Station, Sulaimani Agricultural Directorate, Ministry of Agriculture and Water Recourses during the autumn season of 2020-2021. The field experiment was laid out according to factor

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Karadag, Musa. "Nigella sativa L. SEED PASTE INTO A VALUE ADDED PRODUCT BY RECYCLING." Advances in Biology & Earth Sciences 9, Special Issue (2024): 92–96. http://dx.doi.org/10.62476/abes9s92.

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Pollution of the environment is one of the most significant problems of our generation and the future as our living spaces shrink. Waste materials is the first of many sources of environmental pollution. Waste must be evaluated and reused in recycling facilities to ensure environmental order and balance. This study evaluated the pulp of the Nigella sativa L., seed plant, whose oil was removed by a cold pressing method and turned it into value-added products. Particularly, pulp and Nigella sativa L., seeds have healing and nutritionally rich qualities. Nigella sativa L., pulp was made into a sk

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Ciesielska-Figlon, Klaudia, Karolina Wojciechowicz, Anna Wardowska, and Katarzyna Aleksandra Lisowska. "The Immunomodulatory Effect of Nigella sativa." Antioxidants 12, no. 7 (2023): 1340. http://dx.doi.org/10.3390/antiox12071340.

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Background: For thousands of years till nowadays, Nigella sativa (NS) has served as a common spice and food preservative. Its seed extracts, seed oil, and essential oil in traditional medicine have been used to remedy many ailments such as headaches, fever, gastric complaints, and even rheumatism. In addition, the antibacterial, virucidal, fungicidal, and antiparasitic properties of NS are well known. However, studies on the possible immunomodulatory effects of black cumin are relatively scarce. This article discusses in vitro and in vivo research supporting the immunomodulatory role of NS. Me

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