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1

Sharma, S. K., and A. Sharma. "ELECTROCHEMICAL STUDIES OF NITRO BENZOIC ACIDS AT DIFFERENT pH ON GLASSY CARBON AND STAINLESS STEEL (SS-316) ELECTRODE." Rasayan Journal of Chemistry 15, no. 01 (2022): 350–58. http://dx.doi.org/10.31788/rjc.2022.1516478.

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Reduction behaviors of o, m and p nitro benzoic acids have been investigated electrochemically on glassy carbon and stainless steel (SS-316) electrodes. The aqueous methanolic solution (1:1) of o,m and p nitro benzoic acids (1mM each) was used to observe the effects of scan rates at pH 5.0,7.0 and 9.0. At various scan rates, peak potential (Ep) shifted towards the cathodic side which indicates that these reductions are irreversible and diffusion-controlled processes. The linear nature of Ipc vs.√V plots and constant values of Ipc vs.√V indicates nitrobenzoic acids reduction is a diffusion-cont
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2

Ilangovan, Andivelu, Palaniappan Sakthivel, and Pandaram Sakthivel. "Green and practical transition metal-free one-pot conversion of substituted benzoic acids to anilines using tosyl azide." Organic Chemistry Frontiers 3, no. 12 (2016): 1680–85. http://dx.doi.org/10.1039/c6qo00343e.

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A simple and efficient method for conversion of 2-iodo/2-nitro benzoic acids and dihydropyranone-fused benzoic acids into corresponding anilines, using tosyl azide, under transition metal-free conditions was developed. Steric and electronic effects play crucial role.
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3

Zhang, Shu Xin. "Research on Synthesis of Benzoic Acids Intermediates." Applied Mechanics and Materials 192 (July 2012): 270–74. http://dx.doi.org/10.4028/www.scientific.net/amm.192.270.

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This article briefly describes the development of dye intermediates in China and the research and development situation on synthetic 2 - amino-5 - nitrobenzoic acids. It also tries two more new routes to practice synthesis of them, for which it focuses on speculation of the reaction mechanism of the former route and on research of process conditions of the latter, getting the optimal conditions of the synthetic 5 - nitro-isatin. 2 - Amino - 5 - nitro benzoic acid is a versatile organic intermediate, which is seldom reported both home and abroad, but research on its synthesis method and process
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4

Zhang, Xiang, Jian Chen, Jinzhong Hu, et al. "The solubilities of benzoic acid and its nitro-derivatives, 3-nitro and 3,5-dinitrobenzoic acids." Journal of Chemical Research 45, no. 11-12 (2021): 1100–1106. http://dx.doi.org/10.1177/17475198211058617.

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The solubilities of benzoic acid and its nitrated derivatives (3-nitrobenzoic acid and 3,5-dinitrobenzoic acid) in seven pure solvents—water, methanol, ethanol, acetonitrile, dichloromethane, toluene, and ethyl acetate—were determined experimentally over a temperature range from 273.15 K to 323.15 K under 101.3 kPa. The solubility of the above substances in these solvents increased with temperature. The solubility values of benzoic acid in these seven solvents follow the following order: ethanol > ethanol > acetonitrile > ethyl acetate > dichloromethane > toluene > water, whi
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5

UPENDRA, N. DAS. "Thermodynamic Functions of Ionisation of Benzoic and Substituted Benzoic Acids in Dioxan-Water Mixtures." Journal of Indian Chemical Society Vol. 72, Jul 1995 (1995): 453–59. https://doi.org/10.5281/zenodo.5905197.

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Department of Chemistry&nbsp;Utkal University. Bhubancswar-751 004 <em>Manuscript received 12 July 1993. revised 17 December 1993. accepted 13 .January 1994</em> Free energies&nbsp;of transfer&nbsp;of benzoic and of ortho,&nbsp;meta- and para-substituted nitro, chloro, hydroxy&nbsp;and aminobenzoic&nbsp;acids from&nbsp;water&nbsp;to dioxan-water&nbsp;mixtures have been estimated from theromdynamic ionisation constants. <sup>T</sup><em>P</em>K\( \begin{matrix} m \\ a \\ \end{matrix}\)&nbsp;of&nbsp;these acids obtained&nbsp;from the electromotive force measurements of buffer cells. The&nbsp;effe
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6

Zhou, Leijie, Stefania Perulli, Marco M. Mastandrea, Patricia Llanes, Junshan Lai, and Miquel A. Pericàs. "Development of a robust immobilized organocatalyst for the redox-neutral mitsunobu reaction." Green Chemistry 23, no. 22 (2021): 8859–64. http://dx.doi.org/10.1039/d1gc02819g.

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An immobilized, recyclable (2-hydroxybenzyl)diphenylphosphine oxide analogue has been synthesized and used in the redox-neutral Mitsunobu inversion of secondary alcohols with nitro substituted benzoic acids (up to 97% yield and 98% specificity).
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7

Vashurin, Artur, Vladimir Maizlish, Ilya Kuzmin, et al. "Symmetrical and difunctional substituted cobalt phthalocyanines with benzoic acids fragments: Synthesis and catalytic activity." Journal of Porphyrins and Phthalocyanines 21, no. 01 (2017): 37–47. http://dx.doi.org/10.1142/s108842461750002x.

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Difunctional and symmetric phthalonitriles were synthesized by nucleophilic substitution of brome and nitro-group in 4-bromo-5-nitro-phthalonitrile for residues 4-amino-, 4-hydroxyl- and 4-sulfanyl benzoic acid. Symmetrical and difunctional substituted cobalt phthalocyanines were obtained by template synthesis based on mentioned phthalonitriles. Their spectral properties and catalytic activity in aerobic oxidation of sodium [Formula: see text],[Formula: see text]-carbomoditiolate were investigated.
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8

Nath, J. K. "Syntheses, crystal structure, Hirshfeld Surface Analyzes of cocrystals and salt of a flexible imidazole tethered naphthalenediimide with some organic acids." Журнал структурной химии 66, no. 1 (2025): 138343. http://dx.doi.org/10.26902/jsc_id138343.

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One salt and three cocrystals of 2,7-bis(3-(1H-imidazol-1-yl)propyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone (L) have been synthesized and reported. 3-Nitro benzoic acid (3NBA) forms salt with L and 4-Nitro benzoic acid (4NBA), 4-Hydroxy benzoic acid (4HBA) and 4-Amino benzoic acid (4ABA) forms cocrystals with L. L forms 1:1 salt with 3-NBA and 1:1 cocrystal with 4-NBA, 4-HBA and 4-ABA respectively. All the complexes were formed in a warm solvent condition. The solid-state structures were determined by single crystal X-ray diffraction method. Salt 1, exhibit zig zag tetrameric wat
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9

Hossian, Asik, Kartic Manna, Pritha Das, and Ranjan Jana. "CuI /AgI -Promoted Decarboxylative Alkynylation of ortho-Nitro Benzoic Acids." ChemistrySelect 3, no. 16 (2018): 4315–18. http://dx.doi.org/10.1002/slct.201800758.

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10

Kurfürst, Antonín, Pavel Lhoták, Petr Nádeník, Františka Raclová-Pavlíková, and Josef Kuthan. "2-(Biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD): Electrophilic 4’-substitution and following transformations." Collection of Czechoslovak Chemical Communications 56, no. 7 (1991): 1495–504. http://dx.doi.org/10.1135/cccc19911495.

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PBD was converted into 4’-substituted derivatives I-XII using usual electrophilic reagents. The decomposition of PBD, 4’-acetyl derivative I and 4’-nitro derivative VI with hydroiodic acid gave 4’-substituted 4-biphenylcarboxylic acids XIIIa-XIIIc and benzoic acid, respectively. The regioselectivity of the reaction was also proved by means of high resolution NMR spectroscopy.
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11

KUMAR, CH RAVI SHANKAR, S. SREEHARI SASTRY, and T. MADHU MOHAN. "FORMATION OF CRYSTAL G PHASE IN HYDROGEN BONDED MESOGEN CONSTRUCTED BY p-n-ALKYL BENZOIC ACIDS WITH ORTHO-TOLUAMIDE." International Journal of Modern Physics B 23, no. 14 (2009): 3187–94. http://dx.doi.org/10.1142/s0217979209052339.

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New supramolecular hydrogen bonded mesogens are designed with the non-covalent interactions between the two polar groups. Interesting observations made in the synthesis of new hydrogen bonded mesogen between the mesogenic group p-n-alkyl benzoic acid with n representing the alkyl carbon number from pentyl to decyl of benzoic acid group and non-mesogen ortho-toluamide containing nitro group. The thermodynamic properties of the observed textures are studied by polarizing optical microscope and compared with the corresponding differential scanning calorimetry. The results of hydrogen-bonded mesog
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12

SAROJ, K. GHOSH, and K. HAZRA DILIP. "Solubilities and Free Energies of Transfer for p-Nitro-and p-Chloro-benzoic Acids in Aqueous Mixtures of 2-Methoxyethanol and 1,2-Dimethoxyethane." Journal of Indian Chemical Society Vol. 65, Sep 1988 (1988): 620–23. https://doi.org/10.5281/zenodo.6034912.

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Department of Chemistry, North Bengal University, Darjeeling-734 430 <em>Manuscript received 11 March 1988, revised 23 May 1988, accepted 6 July 1988</em> The solubilities of the <em>p</em>-nitro- and <em>p</em>-chloro-benzoic acids in 2-methoxye thanol (ME) + water and 1,2-dimethoxyethane (DME)+ water mixtures at 25&deg; have been measured. The thermodynamic dissociation constants of the acids have been deter&shy;mined from pH and solubility measurements. The free energies of transfer of <em>p</em>-nitro&shy;-and <em>p</em>-chloro-benzoate ions [\(\bigtriangleup\)\(G^o_t\)&nbsp;(&nbsp;\(A^-\)
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13

Pais, João P., Olha Antoniuk, Raquel Freire, et al. "Nitrobenzoates and Nitrothiobenzoates with Activity against M. tuberculosis." Microorganisms 11, no. 4 (2023): 969. http://dx.doi.org/10.3390/microorganisms11040969.

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Esters of weak acids have shown improved antimycobacterial activity over the corresponding free acids and nitro benzoates in particular have previously shown to have a very intriguing activity. To expand the potential of nitro-derivatives of benzoic acid as antimycobacterial drugs and explore the effects of various structural features on the activity of these compounds, we have obtained a library of 64 derivatives containing esters and thioesters of benzoates and studied their activity against M. tuberculosis, the stability of the compounds, their activation by mycobacterial enzymes and the po
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14

Guranova, Natalia, Lyudmila Yakovleva, Olga Bakulina, Dmitry Dar’in та Mikhail Krasavin. "Extending the Scope of the New Variant of the Castagnoli–Cushman Cyclocondensation onto o-Methyl Benzoic Acids Bearing Various Electron-Withdrawing Groups in the α-Position". Molecules 27, № 21 (2022): 7211. http://dx.doi.org/10.3390/molecules27217211.

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Based on the previously reported involvement of homophthalic acid monoesters in the Castagnoli–Cushman reaction-type cyclocondensation with imines, we tested a number of other o-methyl benzoic acids bearing various electron-withdrawing groups in the α-position. The majority of these substrates delivered the expected tetrahydroisoquinolone adducts on activation with CDI or acetic anhydride. Homophthalic acid mononitriles displayed the highest promise as substrates for the new reaction, both in terms of scope and product yields. Homophthalic acid monoamides either gave low yields or failed to re
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15

Bagrov, F. V., E. P. Vasil'ev, V. A. Efimov, and N. I. Kol'tsov. "ChemInform Abstract: N-[Hydroxy(amino)alkyl]amides of Amino(nitro)benzoic Acids." ChemInform 32, no. 5 (2001): no. http://dx.doi.org/10.1002/chin.200105083.

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16

Pais, João P., Marta Magalhães, Olha Antoniuk, et al. "Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis." Pharmaceuticals 15, no. 9 (2022): 1118. http://dx.doi.org/10.3390/ph15091118.

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One interesting approach to fight tuberculosis is the use of prodrugs that often have shown improved biological activities over drugs with poor absorption or difficulty to cross membranes. Previous studies demonstrate that weak acids such as benzoic acid, present antimycobacterial activity. Moreover, esters of those acids revealed to be a viable alternative since they may diffuse more easily through the cell membranes. Previously we showed that mycobacteria can easily activate benzoic acid esters by conversion to the corresponding acid. Since Zhang postulated that the activity of the acids can
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17

Prabu, N. Pongali Sathya, and M. L. N. Madhu Mohan. "Analysis of hydrogen-bonded liquid crystals formed between nitro-substituted benzoic acid and p-n-alkyloxy benzoic acids." Molecular Crystals and Liquid Crystals 631, no. 1 (2016): 47–63. http://dx.doi.org/10.1080/15421406.2016.1149019.

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18

Badilescu, Simona, P. V. Ashrit, Vo-Van Truong, and I. I. Badilescu. "Enhanced Infrared ATR Spectra of O-, m-, and p-Nitrobenzoic Acid with Ag Films." Applied Spectroscopy 43, no. 3 (1989): 549–52. http://dx.doi.org/10.1366/0003702894202850.

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The dependence of enhancement of the infrared bands by thin Ag films on the molecular structure of the organic compound was investigated. A different enhancement behavior for the three isomers—ortho-, meta-, and paranitrobenzoic acids—was observed and accounted for by structural features. The presence of the ionized species of the acids in the monolayer bonded to Ag was found, and the spectral features of the monolayer and bulk compound were compared. The splitting of the antisymmetric stretching band of the nitro group for metanitro benzoic acid strongly interacting with Ag was observed. The
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19

Huang, Liquan, Jie Cao, Hong Wang, Lynn A. Vo, and Joseph G. Brand. "Identification and Functional Characterization of a Voltage-gated Chloride Channel and Its Novel Splice Variant in Taste Bud Cells." Journal of Biological Chemistry 280, no. 43 (2005): 36150–57. http://dx.doi.org/10.1074/jbc.m507706200.

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Taste bud cells are epithelial cells with neuronal properties. Voltage-dependent ion channels have been physiologically described in these cells. Here, we report the molecular identification and functional characterization of a voltage-gated chloride channel (ClC-4) and its novel splice variant (ClC-4A) from taste bud cells. ClC-4A skipped an exon near its 5′-end, incurring the loss of 60 amino acids at the N terminus. In situ hybridization and immunohistochemistry localized these two channels' transcripts and proteins to a subset of taste bud cells. Electrophysiological recordings of the hete
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20

Srinivasan, B. R., and Sarvesh C. Sawant. "Thermal and spectroscopic characterization of Mg(II) complexes of nitro-substituted benzoic acids." Thermochimica Acta 402, no. 1-2 (2003): 45–55. http://dx.doi.org/10.1016/s0040-6031(02)00533-6.

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21

Skinner, Philip J., Martin C. Cherrier, Peter J. Webb, et al. "3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b." Bioorganic & Medicinal Chemistry Letters 17, no. 23 (2007): 6619–22. http://dx.doi.org/10.1016/j.bmcl.2007.09.058.

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22

Li, Ying, Zhao Tang, Junsu Jin, and Zeting Zhang. "Binary and ternary solubility of amino- and nitro-benzoic acids in supercritical carbon dioxide." Fluid Phase Equilibria 344 (April 2013): 71–78. http://dx.doi.org/10.1016/j.fluid.2013.01.021.

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23

Lynch, DE, G. Smith, NJ Calos, et al. "Molecular Cocrystals of Carboxylic Acids. XIII. Spectral Characterization of the Adducts of Triphenylphosphine Oxide With Substituted Benzoic Acids and the Crystal Structures of the 1 : 1 Adducts With 2,4,6-Trinitrobenzoic Acid and 3,5-Dinitrobenzoic Acid." Australian Journal of Chemistry 46, no. 10 (1993): 1535. http://dx.doi.org/10.1071/ch9931535.

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The 1:1 adducts of triphenylphosphine oxide with the 2-, 3- and 4-nitro-, 3,5-dinitro-, and 2,4,6-trinitro-substituted benzoic acids have been prepared, and characterized by infrared and 31P n.m.r. spectroscopy. The crystal structures of two of these adducts, (triphenylphosphine oxide-3,5-dinitrobenzoic acid) and ( triphenylphosphine oxide-2,4,6-trinitrobenzoic acid), have been determined by X-ray diffraction. In all examples, the presence of single directed hydrogen bonds between the phosphoryl oxygen and the carboxylic acid proton is confirmed. For the X-ray structures, the O…O distances are
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24

Sanchez-Olea, R., M. Morales, O. Garcia, and H. Pasantes-Morales. "Cl channel blockers inhibit the volume-activated efflux of Cl and taurine in cultured neurons." American Journal of Physiology-Cell Physiology 270, no. 6 (1996): C1703—C1708. http://dx.doi.org/10.1152/ajpcell.1996.270.6.c1703.

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The effects of the Cl channel blockers 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 1,9-dideoxyforskolin (DDF), dipyridamole, and niflumic acid and of the polyunsaturated fatty acids arachidonic, linolenic, and linoleic acids on regulatory volume decrease (RVD) and associated 125I and [3H]taurine fluxes in cultured rat cerebellar granule neurons were examined. Dose-response curves of NPPB, DDF, and dipyridamole showed 20-100% inhibition of RVD and osmolyte fluxes. Niflumic acid was less potent, requiring 150-600 microM to show effects of this magnitude. The polyunsaturated fatty acids (
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25

Lynch, Daniel E., Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Designing Linear Hydrogen-Bonded Arrays by Using Substituted Charge-Transfer Complexes. The Crystal Structure of the 1 : 1 Adduct of Indole-2-carboxylic Acid with 3,5-Dinitrobenzoic Acid." Australian Journal of Chemistry 51, no. 11 (1998): 1019. http://dx.doi.org/10.1071/c98119.

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Five adducts consisting of carboxylic acid-substituted indoles with nitro-substituted benzoic acids have been synthesized and tested for second-order non-linear optical properties. These were indole-2-carboxylic acid with 2,4-dinitrobenzoic acid (1), 3,5-dinitrobenzoic acid (2), and 2,4,6-trinitrobenzoic acid (3), and indole-3-acetic acid with 3,5-dinitrobenzoic acid (4), and 2,4,6-trinitrobenzoic acid (5). Compound (2) produced clear, yellow crystals (space group P -1 with a 6·8400(7), b 15·150(2), c 16·097(2) Å, α 84·911(9), β 87·088(10), γ 77·865(9)°, Z 4) which allowed the structure to be
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26

Moran, J., D. Miranda, C. Pena-Segura, and H. Pasantes-Morales. "Volume regulation in NIH/3T3 cells not expressing P-glycoprotein. II. Chloride and amino acid fluxes." American Journal of Physiology-Cell Physiology 272, no. 6 (1997): C1804—C1809. http://dx.doi.org/10.1152/ajpcell.1997.272.6.c1804.

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The osmolyte function of amino acids and Cl in native NIH/3T3 cells not expressing the P-glycoprotein was examined by investigating the free amino acid concentration and the swelling-activated efflux of [3H]taurine, as representative of amino acids, and of 125I, as a tracer for Cl. Taurine and 125I efflux was activated by 20 and 30% hyposmotic solutions. At 50% hyposmotic solutions, the osmolyte pool was essentially depleted. The Cl channel blockers 5-nitro-2-(3-phenylpropyl-amino)benzoic acid, 1,9-dideoxyforskolin, dipyridamole, and niflumic acid inhibited the release of the two osmolytes by
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27

Ivanov, S. N., N. I. Giricheva, T. V. Nurkevich, and M. S. Fedorov. "Energies of the gas-phase deprotonation of nitro-substituted benzenesulfonic and benzoic acids: The role of the conformation isomerism of sulfonic acids." Russian Journal of Physical Chemistry A 88, no. 4 (2014): 661–66. http://dx.doi.org/10.1134/s0036024414040104.

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28

Kolde, H.-J., R. Eberle, H. Hebert, and N. Heimburger. "New Chromogenic Substrates for Thrombin with Increased Specificity." Thrombosis and Haemostasis 56, no. 02 (1986): 155–59. http://dx.doi.org/10.1055/s-0038-1661631.

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SummaryChromogenic substrates for thrombin with high specificity are necessary for several functional assays, especially for the performance of photometric PT and APTT. A new approach to improve the specificity of chromogenic peptide substrates is made coupling tripeptide sequences selective for thrombin to derivatives of 5-amino-2-nitro benzoic acid (ANBA). Especially when the chromophore’s side chain is substituted by amines or amino acids hydrolysis rates by other enzymes like kallikrein, plasmin or factor Xa are decreased significantly compared to corresponding para-nitroanilides of the sa
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29

Mountian, I., P. E. Declercq, and W. Van Driessche. "Volume regulation in rat brain glial cells: lack of a substantial contribution of free amino acids." American Journal of Physiology-Cell Physiology 270, no. 5 (1996): C1319—C1325. http://dx.doi.org/10.1152/ajpcell.1996.270.5.c1319.

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Volume regulation of C6 glioma cells was studied while the bath osmolality was reduced from 300 to 150 mosmol/kg. Exposure to a hyposmotic challenge elicited a typical regulatory volume decrease (RVD). No regulatory volume increase was observed upon restoration of isosmotic conditions. During a second subsequent hyposmotic challenge, the cells did not respond with RVD. High extracellular K+ concentration and the K+ channel blockers Ba2+ and quinine inhibited the RVD. RVD was abolished after Cl- was replaced by gluconate and by the Cl- channel blocker 5-nitro-2(3-phenylpropylamino)benzoic acid.
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Pasantes-Morales, H., R. Sanchez Olea, D. Miranda, and J. Moran. "Volume regulation in NIH/3T3 cells not expressing P-glycoprotein. I. Regulatory volume decrease." American Journal of Physiology-Cell Physiology 272, no. 6 (1997): C1798—C1803. http://dx.doi.org/10.1152/ajpcell.1997.272.6.c1798.

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Exposure of NIH/3T3 fibroblasts not expressing P-glycoprotein to 50, 30, 20, and 10% hyposmotic solutions led to cell volume increases of 70, 32, 21, and 12%, respectively. After swelling, NIH/3T3 cells exhibited regulatory volume decrease (RVD), attaining complete volume recovery after 30 min except in 50% hyposmotic solution, in which volume recovery was 76%. RVD was accelerated by gramicidin and inhibited by the Cl channel blockers 5-nitro-2-(3-phenylpropylamino)-benzoic acid, 1,9-dideoxyforskolin, dipyridamole, and niflumic acid and by the K channel, blocker quinidine. RVD was reduced 15%
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31

Lynch, Daniel E., Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Molecular Cocrystals of Carboxylic Acids. XXVI Adducts of the Amino-Substituted Benzoic Acids with Nitroaromatic Lewis Bases: the Influence of Associative Polyfunctional Substituents on Self-Assembly of Molecules in Cocrystallization Processes." Australian Journal of Chemistry 50, no. 10 (1997): 977. http://dx.doi.org/10.1071/c97067.

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A series of molecular adducts of the isomeric aminobenzoic acids with the nitro-substituted Lewis bases 2-chloro-5-nitropyridine, 5-nitroquinoline and 5-nitroisoquinoline has been prepared and characterized by using infrared spectroscopy and X-ray powder diffraction, and in four cases by single-crystal X-ray diffraction methods. These four compounds are the adducts of 3-aminobenzoic acid with 5-nitroquinoline [(C7H7NO2)(C9H6N2O2)], 4-aminobenzoic acid with 5-nitroquinoline [(C7H7NO2)2(C9H6N2O2)], 2-aminobenzoic acid with 5-nitroisoquinoline [(C7H7NO2)(C9H6N2O2)] and 4-aminobenzoic acid with 5-
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32

Singh, A. K., G. B. Afink, C. J. Venglarik, R. P. Wang, and R. J. Bridges. "Colonic Cl channel blockade by three classes of compounds." American Journal of Physiology-Cell Physiology 261, no. 1 (1991): C51—C63. http://dx.doi.org/10.1152/ajpcell.1991.261.1.c51.

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We compared the potency and inhibitory actions of three different classes of organic acids on a Cl channel derived from colonic enterocyte plasma membrane vesicles. Chloride channels were incorporated into planar lipid bilayer membranes to examine the effects of the anthranilic acids, diphenylamine 2-carboxylic acid (DPC) and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), the indanyl alkanoic acids, 2-[(2-cyclopentyl-6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-1H-inden -5-yl)oxy] acetic acid (IAA-94) and its stereoenantiomer IAA-95, and the disulfonic stilbene, 4,4'-dinitro-stilbene-2,2'-disu
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33

Vidyasagar, Sadasivan, Christian Barmeyer, John Geibel, Henry J. Binder, and Vazhaikkurichi M. Rajendran. "Role of short-chain fatty acids in colonic HCO3secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 6 (2005): G1217—G1226. http://dx.doi.org/10.1152/ajpgi.00415.2004.

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Luminal isobutyrate, a relatively poor metabolized short-chain fatty acid (SCFA), induces HCO3secretion via a Cl-independent, DIDS-insensitive, carrier-mediated process as well as inhibiting both Cl-dependent and cAMP-induced HCO3secretion. The mechanism(s) responsible for these processes have not been well characterized. HCO3secretion was measured in isolated colonic mucosa mounted in Lucite chambers using pH stat technique and during microperfusion of isolated colonic crypts.14C-labeled butyrate,14C-labeled isobutyrate, and36Cl uptake were also determined by apical membrane vesicles (AMV) is
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34

Reboredo, Francisco J., Mónica Treus, Juan C. Estévez, Luis Castedo, and Ramón J. Estévez. "Nitro-facilitated ‘5-Exo-dig’ Intramolecular Cyclisation of 2-(2-Nitrophenylethynyl)benzoic Acids: A New Total Synthesis of Indeno[1,2-b]indoles." Synlett 2002, no. 06 (2002): 0999–1001. http://dx.doi.org/10.1055/s-2002-31896.

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35

Reboredo, Francisco J., Monica Treus, Juan C. Estevez, Luis Castedo, and Ramon J. Estevez. "Nitro-facilitated “5-Exo-dig” Intramolecular Cyclization of 2-(2-Nitrophenylethynyl)benzoic Acids: A New Total Synthesis of Indeno[1,2-b]indoles." ChemInform 33, no. 40 (2002): 129. http://dx.doi.org/10.1002/chin.200240129.

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36

Okolo, Charles, Thomas Wong, Mark W. Moody, and Toan D. Nguyen. "Effects of bile acids on dog pancreatic duct epithelial cell secretion and monolayer resistance." American Journal of Physiology-Gastrointestinal and Liver Physiology 283, no. 5 (2002): G1042—G1050. http://dx.doi.org/10.1152/ajpgi.00436.2001.

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Pancreatic duct epithelial cells (PDEC) mediate the secretion of fluid and electrolytes and are exposed to refluxed bile. In nontransformed cultured dog PDEC, which express many ion transport pathways of PDEC, 1 mM taurodeoxycholic acid (TDCA) stimulated an125I−efflux inhibited by DIDS and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) and a86Rb+efflux inhibited by charybdotoxin. Inhibition by 1,2-bis(2-aminophenoxy)ethane- N,N,N′,N′-tetraacetic acid (BAPTA)-AM suggests mediation via increased intracellular Ca2+concentration, whereas the absence of lactate dehydrogenase release excludes ce
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37

Lidofsky, Steven D., and Richard M. Roman. "Alanine uptake activates hepatocellular chloride channels." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 4 (1997): G849—G853. http://dx.doi.org/10.1152/ajpgi.1997.273.4.g849.

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Cells involved in the retrieval and metabolic conversion of amino acids undergo significant increases in size in response to amino acid uptake. The resultant adaptive responses to cell swelling are thought to include increases in membrane K+ and Cl− permeability through activation of volume-sensitive ion channels. This viewpoint is largely based on experimental models of hypotonic swelling, but few mammalian cells experience hypotonic challenge in vivo. Here we have examined volume regulatory responses in a physiological model of cell-swelling alanine uptake in immortalized hepatocytes. Alanin
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38

Manolopoulos, V. G., T. Voets, P. E. Declercq, G. Droogmans, and B. Nilius. "Swelling-activated efflux of taurine and other organic osmolytes in endothelial cells." American Journal of Physiology-Cell Physiology 273, no. 1 (1997): C214—C222. http://dx.doi.org/10.1152/ajpcell.1997.273.1.c214.

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We used a combined biochemical, pharmacological, and electrophysiological approach to study the effects of hyposmotic swelling on organic osmolyte efflux in endothelial cells (EC). In [3H]taurine-loaded monolayers of calf pulmonary artery EC (CPAEC), hyposmolality activated time- and dose-dependent effluxes of [3H]taurine. Swelling-activated [3H]taurine efflux (Jtau swell)in CPAEC was inhibited by the anion channel blockers tamoxifen, 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), fenamates, and also quinine (in a pH-dependent manne
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39

Smith, Graham, and Urs D. Wermuth. "Hydrogen bonding in the anhydrous 1:1 proton-transfer compounds of isonipecotamide with nitro-substituted benzoic acids: the salts of the three isomeric mononitrobenzoic acids and of 3,5-dinitrobenzoic acid." Acta Crystallographica Section C Crystal Structure Communications 66, no. 12 (2010): o614—o618. http://dx.doi.org/10.1107/s0108270110045750.

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40

Rutledge, Eric M., Michael Aschner, and Harold K. Kimelberg. "Pharmacological characterization of swelling-induced d-[3H]aspartate release from primary astrocyte cultures." American Journal of Physiology-Cell Physiology 274, no. 6 (1998): C1511—C1520. http://dx.doi.org/10.1152/ajpcell.1998.274.6.c1511.

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During stroke or head trauma, extracellular K+concentration increases, which can cause astrocytes to swell. In vitro, such swelling causes astrocytes to release excitatory amino acids, which may contribute to excitotoxicity in vivo. Several putative swelling-activated channels have been identified through which such anionic organic cellular osmolytes can be released. In the present study, we sought to identify the swelling-activated channel(s) responsible ford-[3H]aspartate release from primary cultured astrocytes exposed to either KCl or hypotonic medium. KCl-inducedd-[3H]aspartate release wa
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41

Smith, Graham, and Daniel E. Lynch. "Cyclic heterotetrameric and low-dimensional hydrogen-bonded polymeric structures in the morpholinium salts of ring-substituted benzoic acid analogues." Acta Crystallographica Section C Structural Chemistry 72, no. 2 (2016): 105–11. http://dx.doi.org/10.1107/s2053229615024821.

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The morpholinium (tetrahydro-2H-1,4-oxazin-4-ium) cation has been used as a counter-ion in both inorganic and organic salt formation and particularly in metal complex stabilization. To examine the influence of interactive substituent groups in the aromatic rings of benzoic acids upon secondary structure generation, the anhydrous salts of morpholine with salicylic acid, C4H10NO+·C7H5O3−, (I), 3,5-dinitrosalicylic acid, C4H10NO+·C7H3N2O7−, (II), 3,5-dinitrobenzoic acid, C4H10NO+·C7H3N2O6−, (III), and 4-nitroanthranilic acid, C4H10NO+·C7H5N2O4−, (IV), have been prepared and their hydrogen-bonded
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42

Jaoui, Mohammed, Kenneth S. Docherty, Michael Lewandowski, and Tadeusz E. Kleindienst. "Yields and molecular composition of gas-phase and secondary organic aerosol from the photooxidation of the volatile consumer product benzyl alcohol: formation of highly oxygenated and hydroxy nitro-aromatic compounds." Atmospheric Chemistry and Physics 23, no. 8 (2023): 4637–61. http://dx.doi.org/10.5194/acp-23-4637-2023.

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Abstract. Recently, volatile chemical products (VCPs) have been increasingly recognized as important precursors for secondary organic aerosol (SOA) and ozone in urban areas. However, their atmospheric chemistry, physical transformation, and impact on climate, environment, and human health remain poorly understood. Here, the yields and chemical composition at the molecular level of gas- and particle-phase products originating from the photooxidation of one of these VCPs, benzyl alcohol (BnOH), are reported. The SOA was generated in the presence of seed aerosol from nebulized ammonium sulfate so
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43

Basavappa, S., C. C. Huang, A. W. Mangel, D. V. Lebedev, P. A. Knauf, and J. C. Ellory. "Swelling-activated amino acid efflux in the human neuroblastoma cell line CHP-100." Journal of Neurophysiology 76, no. 2 (1996): 764–69. http://dx.doi.org/10.1152/jn.1996.76.2.764.

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1. The effects of hypoosmotic stress on cell volume and amino acid efflux were evaluated in the human neuroblastoma cell line CHP-100 with the Coulter Counter Multisizer and radiolabeled amino acid efflux, respectively. 2. CHP-100 cells swelled by approximately 35 +/- 5% (means +/- SE) when the osmolarity of the solution was decreased from 290 to 190 mOsm/kg H2O. The rapid swelling was followed by a biphasic regulatory volume decrease (RVD). 3. In cells loaded with 14C-taurine, hypoosmotic stress induced a 300 +/- 22% (n = 23, P &lt; 0.05) increase in taurine efflux compared with controls. Thi
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44

Ishida, Hiroyuki. "Role of pK a in establishing the crystal structures of six hydrogen-bonded compounds of 4-methylquinoline with different isomers of chloro- and nitro-substituted benzoic acids." Acta Crystallographica Section E Crystallographic Communications 77, no. 11 (2021): 1144–52. http://dx.doi.org/10.1107/s2056989021010896.

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The structures of the six hydrogen-bonded 1:1 compounds of 4-methylquinoline (C10H9N) with chloro- and nitro-substituted benzoic acids (C7H4ClNO4), namely, 4-methylquinolinium 2-chloro-4-nitrobenzoate, C10H10N+·C7H3ClNO4 −, (I), 4-methylquinoline–2-chloro-5-nitrobenzoic acid (1/1), C10H9N·C7H4ClNO4, (II), 4-methylquinolinium 2-chloro-6-nitrobenzoate, C10H9.63N0.63+·C7H3.37ClNO4 0.63−, (III), 4-methylquinolinium 3-chloro-2-nitrobenzoate, C10H9.54N0.54+·C7H3.46ClNO4 0.54−, (IV), 4-methylquinolinium 4-chloro-2-nitrobenzoate, C10H10N+·C7H3ClNO4 −, (V), and 4-methylquinolinium 5-chloro-2-nitrobenzo
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45

Sharma, Omprakash, Pankaj Sharma, Birendra Shrivastava, and Jitender Singh. "Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives." Asian Pacific Journal of Health Sciences 5, no. 4 (2018): 54–60. http://dx.doi.org/10.21276/apjhs.2018.5.4.10.

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46

Gotoh, Kazuma, and Hiroyuki Ishida. "Crystal structures of four isomeric hydrogen-bonded co-crystals of 6-methylquinoline with 2-chloro-4-nitrobenzoic acid, 2-chloro-5-nitrobenzoic acid, 3-chloro-2-nitrobenzoic acid and 4-chloro-2-nitrobenzoic acid." Acta Crystallographica Section E Crystallographic Communications 76, no. 11 (2020): 1701–7. http://dx.doi.org/10.1107/s2056989020013134.

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The structures of the four isomeric compounds of 6-methylquinoline with chloro- and nitro-substituted benzoic acids, C7H4ClNO4·C10H9N, namely, 2-chloro-4-nitrobenzoic acid–6-methylquinoline (1/1), (I), 2-chloro-5-nitrobenzoic acid–6-methylquinoline (1/1), (II), 3-chloro-2-nitrobenzoic acid–6-methylquinoline (1/1), (III), and 4-chloro-2-nitrobenzoic acid–6-methylquinoline (1/1), (IV), have been determined at 185–190 K. In each compound, the acid and base molecules are linked by a short hydrogen bond between a carboxyl O atom and an N atom of the base. The O...N distances are 2.5452 (12), 2.6569
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47

Prasad, A. V. G. S., and P. Venkateswara Rao. "One-Pot Synthesis of Schiff Base Compounds Derived From 2-Nitro Benzoic Acid With Aldehydes." Journal of Chemistry, Environmental Sciences and its Applications 1, no. 1 (2014): 7–14. http://dx.doi.org/10.15415/jce.2014.11001.

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48

Sanchez-Olea, R., C. Fuller, D. Benos, and H. Pasantes-Morales. "Volume-associated osmolyte fluxes in cell lines with or without the anion exchanger." American Journal of Physiology-Cell Physiology 269, no. 5 (1995): C1280—C1286. http://dx.doi.org/10.1152/ajpcell.1995.269.5.c1280.

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To investigate the involvement of a red cell-type anion exchanger in the volume-sensitive amino acid release, the hyposmolarity-evoked release of D-[3H]aspartate and [3H]taurine was examined in three cell lines: 1) wild-type Chinese hamster ovary (CHO-K1) cells, expressing an anion exchanger activity (Cl-/SO4(2-)) functionally similar to the erythroid band 3; 2) a mutant CHO cell type (CHO 605) lacking this anion exchanger activity; and 3) 293 cells in which the Cl-/HCO3(-) anion exchanger is absent. All cell types accumulated D-[3H]aspartate and [3H]taurine under isosmotic conditions, and, si
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49

León Puma, Nicolás Hipólito, and Yubica Allisón León Ramos. "APROXIMACIÓN PROTEÓMICA DE FOSFOLIPASAS A2 (PLA2 Y HOMOLOGA K49) A PARTIR DEL VENENO DE BOTHROPS BARNETTI Y SU BIOPROSPECCIÓN EN ESTUDIOS PROINFLAMATORIOS POR ANÁLISIS BIOINFORMÁTICO. AREQUIPA, 2019." Veritas 22, no. 2 (2022): 151. http://dx.doi.org/10.35286/veritas.v22i2.322.

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Se ha logrado purificar y caracterizar bioquímicamente una fosfolipasa A2 y una homóloga K49 a partir del veneno total de Bothrops barnetti de procedencia peruana. En la purificación de ambas proteínas la fosfolipasa A2 y la fosfolipasa A2 homóloga K49, se ha empleado un paso cromatográfico a través de una cromatografía convencional de interacción hidrofóbica, donde se obtuvo nueve fracciones: denominadas del 1 al 9 respectivamente. La fracción 5 fue caracterizada bioquímicamente como una fosfolipasa A2 al medir su actividad enzimática frente a un sustrato cromogénico altamente específico como
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50

Silva Ferraz, Jose, Vladimir N. Emel´yanenko, Dzmitry H. Zaitsau, et al. "Thermodynamic Insights on the Structure‐Property Relationships in Substituted Benzenes: Are the Pairwise Interactions in Tri‐Substituted Methyl‐Nitro‐Benzoic Acids Still Valid?" ChemPlusChem, February 3, 2025. https://doi.org/10.1002/cplu.202400703.

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A comprehensive experimental thermochemical study of nine methyl‐substituted nitrobenzoic acids was carried out, leading to the final standard molar enthalpies of formation in the gas phase. The combustion energies were measured using high‐precision combustion calorimetry, and the enthalpies of formation of the crystal phase were derived. The sublimation enthalpies were obtained from the vapor pressure‐temperature dependencies measured using the classic Knudsen effusion mass loss and the transpiration methods. The standard molar enthalpies of vaporisation were derived from the temperature depe
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