Relevant bibliographies by topics / Nitro-Mannich

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Nitro-Mannich'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Nitro-Mannich"

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Noble, Adam, and James C. Anderson. "Nitro-Mannich Reaction." Chemical Reviews 113, no. 5 (2013): 2887–939. http://dx.doi.org/10.1021/cr300272t.

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Noble, Adam, and James C. Anderson. "ChemInform Abstract: Nitro-Mannich Reaction." ChemInform 44, no. 27 (2013): no. http://dx.doi.org/10.1002/chin.201327214.

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Anderson, James C., Alexander J. Blake, Paul J. Koovits, and Gregory J. Stepney. "Diastereoselective Reductive Nitro-Mannich Reactions." Journal of Organic Chemistry 77, no. 10 (2012): 4711–24. http://dx.doi.org/10.1021/jo300535h.

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Frank, Priya V., Mahesha Manjunatha Poojary, Naral Damodara, and Chandrashekhar Chikkanna. "Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety." Acta Pharmaceutica 63, no. 2 (2013): 231–39. http://dx.doi.org/10.2478/acph-2013-0016.

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3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.
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Anderson, James C., Ian B. Campbell, Sebastien Campos, Jonathan Shannon, and Derek A. Tocher. "Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction." Organic & Biomolecular Chemistry 13, no. 1 (2015): 170–77. http://dx.doi.org/10.1039/c4ob01793e.

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The sequential use of the conjugate addition nitro-Mannich reaction, nitro reduction and then Pd-catalyzed intramolecular cyclisation allows the concise, stereodivergent synthesis of complex indolines.
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Jakubec, Pavol, Dane M. Cockfield, Madeleine Helliwell, James Raftery, and Darren J. Dixon. "Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles." Beilstein Journal of Organic Chemistry 8 (April 16, 2012): 567–78. http://dx.doi.org/10.3762/bjoc.8.64.

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A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised in a four component one-pot reaction combining an enantioselective organocatalytic Michael addition with the diastereoselective nitro-Mannich/lactamisation cascade. Protodenitration and chemoselective reductive manipulation of the heterocycles was used to install contiguous and fully substituted stereocentres in the synthesis of substituted pi
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Dudek, Agata, and Jacek Mlynarski. "Iron-Catalyzed Asymmetric Nitro-Mannich Reaction." Journal of Organic Chemistry 82, no. 20 (2017): 11218–24. http://dx.doi.org/10.1021/acs.joc.7b01786.

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Gregory, Alex W., Alan Chambers, Alison Hawkins, Pavol Jakubec, and Darren J. Dixon. "Iridium-Catalyzed Reductive Nitro-Mannich Cyclization." Chemistry - A European Journal 21, no. 1 (2014): 111–14. http://dx.doi.org/10.1002/chem.201405256.

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Pelagalli, Alessia, Lucio Pellacani та Stefania Fioravanti. "In Pursuit of β-Amino-α-nitro-β-(trifluoromethyl) Ketones: Nitro-Mannich versus Mannich-Type Reactions". European Journal of Organic Chemistry 2017, № 23 (2017): 3373–80. http://dx.doi.org/10.1002/ejoc.201700510.

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Yoon, Tehshik P., and Eric N. Jacobsen. "Highly Enantioselective Thiourea-Catalyzed Nitro-Mannich Reactions." Angewandte Chemie International Edition 44, no. 3 (2005): 466–68. http://dx.doi.org/10.1002/anie.200461814.

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Dissertations / Theses on the topic "Nitro-Mannich"

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Kalogirou, A. "Development of the conjugate addition/nitro-Mannich reaction." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1389217/.

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This thesis describes the development of the conjugate addition/nitro-Mannich reaction and its use in the synthesis of useful molecules like pyrrolidin-2-ones and piperazin-2-ones. The introductory chapter of this thesis outlines the literature related to the nitro-Mannich reaction, describing the different existing methodologies for performing the reaction in diastereo- and enantioselective manner. The synthetic applications of the reaction are also described, especially its uses in the synthesis of biologically active natural products. Moreover, the syntheses and uses of two classes of compo
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Chapman, Helen A. "Cyclic diamine systems via reduction of nitro-Mannich reaction products." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438334.

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Koovits, P. J. "Development of an enantioselective reductive nitro-Mannich reaction using thiourea catalysis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1388704/.

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The introductory chapter of this thesis describes in detail the chemistry of the nitro-Mannich reaction from its inception to the current “state of the art”. Additionally, the products of the nitro-Mannich reaction and their uses in synthesis are also discussed. The final section of the introduction deals with the use of thiourea organocatalysis and its application in synthetic transformations using imines or nitroalkenes as electrophiles. The results and discussion initially focuses on the development of a racemic reductive nitro-Mannich reaction. It has been found that when using Superhydrid
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Mills, M. R. "The development of a one-pot 1,4-addition/nitro-Mannich reaction." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/134188/.

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The introduction of this thesis reviews the three areas of importance to the research carried out. These are the nitro-Mannich reaction, the conjugate addition of nucleophiles to nitro-alkenes and the diastereoselectivity of electrophilic additions to substrates bearing an α-stereocentre. The Results and Discussion details the research carried out into the development of a one-pot 1,4-addition/nitro-Mannich reaction. Initially the research focused on triggering the reaction using a cyanide nucleophile. Three cyanide sources were investigated, trimethylsilylcyanide, potassium ferrous cyanide an
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Ware, Oliver. "The 1,5- hydride shift as a route into nitro-Mannich cyclisation." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10061846/.

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Carbon-hydrogen bonds are typically not viewed as a reactive site, rather they are commonly the backbone of the molecule to which functional groups are attached. We believed that we could find a method of reacting directly at C-H bonds via a hydride transfer to provide a simple, atom efficient method of constructing carbon-carbon bonds, providing a new target site for small molecule synthesis. Our initial targets for C-H activation were benzylic ethers. This was to be achieved with the use of Lewis acid catalysts to promote hydride transfer. It was initially thought that this transformation co
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Pelletier, Sophie Marie-Clémentine. "One-pot nitro-Mannich cascade reactions : new methodologies and synthetic applications." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:283641bf-bb4e-48a8-8a28-2e048b8c4ea6.

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Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis. An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to perform, broad in scope and tolerates a wide variety of functional groups. For the monocyclic methodology, 28 examp
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Howell, Gareth P. "A general, asymmetric nitro-Mannich reaction for the synthesis of 1,2-diamines." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416417.

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Horsfall, L. R. "Stereoselective synthesis of pyrrolidinones via nitro-Mannich reaction : towards the synthesis of popolohuanone E." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324535/.

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Part 1: The first section of this thesis details the stereoselective synthesis of pyrrolidinones via the nitro-Mannich reaction. Expanding on previous work within the Anderson group, conjugate addition of a diorganozinc species to nitroacrylate 141 was carried out successfully. Subsequent in situ nitro-Mannich reaction was then followed by spontaneous lactamisation to afford the desired five-membered ring pyrrolidinone structure. The reaction was performed in one pot, generating three contiguous stereocentres in a highly diastereoselective manner. The scope of the reaction was investigated by
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Peace, Simon. "The stereoselective nitro-Mannich reaction and its application towards the synthesis of vicinal diamines." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287661.

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Barber, David M. "The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:18e7c533-3789-4800-9813-1d5c7bb4e4ea.

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This thesis describes the development of nitro-Mannich/hydroamination cascade reactions for the synthesis of N-heterocycles, which are important motifs found in a variety of biologically active natural products and pharmaceuticals, such as atorvastatin (Lipitor®). Chapter 2 outlines the development of an efficient synthesis of 2,5-disubstituted pyrroles using a nitro-Mannich/hydroamination cascade. Starting from easily prepared N-protected imines and nitroalkyne substrates, a compatible combination of KOtBu (10 mol%) and AuCl3 (5 mol%) was used to afford the desired pyrrole products, after an
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Book chapters on the topic "Nitro-Mannich"

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Burns, N. Z., and E. N. Jacobsen. "Nitro-Mannich Reaction." In Stereoselective Reactions of Carbonyl and Imino Groups. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-202-00446.

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Burns, N. Z., and E. N. Jacobsen. "Selective Nitro-Mannich Reactions." In Stereoselective Reactions of Carbonyl and Imino Groups. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-202-00448.

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Burns, N. Z., and E. N. Jacobsen. "-Selective and Unsubstituted Nitro-Mannich Reactions." In Stereoselective Reactions of Carbonyl and Imino Groups. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-202-00447.

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Hof, K., K. M. Lippert, and P. R. Schreiner. "Nitro-Mannich Reaction/Aza-Henry Reaction." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00238.

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Nagasawa, K., and Y. Sohtome. "Catalytic Asymmetric Nitro-Mannich-Type Reactions." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00011.

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Nagasawa, K., and Y. Sohtome. "Nitro-Mannich-Type Reactions with Nitroacetates." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00012.

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Nagasawa, K., and Y. Sohtome. "Nitro-Mannich-Type Reactions with α-Substituted Nitroacetates." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00013.

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Taber, Douglass F. "The Dixon Synthesis of Manzamine A." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0100.

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The pentacyclic alkaloid manzamine A 4, isolated from a sponge collected in the Okinawa Sea, displays a range of antibacterial, anticancer, and antimalarial activity. The preparation of 4 reported (J. Am. Chem. Soc. 2012, 134, 17482) by Darren J. Dixon of the University of Oxford showcases the versatility of the nitro group in organic synthesis. The nitro alkene 2 was prepared from the commercial bromide 5. Displacement with acetate followed by Swern oxidation led to the aldehyde 6, which was condensed with nitromethane to give 2. Lactam 1 was an intermediate in Professor Dixon’s synthesis (Org. Highlights May 3, 2010) of (–)-nakadomarin A. Lactam 1 was prepared from the tosylate 7, which was derived from pyroglutamic acid. The addition of 1 to the nitroalkene 2 delivered 3 as the dominant diastereomer of the four that were possible. Mannich condensation with formaldehyde and the amine 12 gave 13. The nitro group of 13 was removed by free radical reduction. Exposure of the reduced product to trimethylsilyl iodide gave, via ionization of the ketal, the primary iodide, which was carried onto the nitro compound 14. Dibal selectively reduced the δ-lactam. Partial reduction of the γ-lactam then gave an intermediate that engaged in Mannich condensation with the nitro-activated methylene to give 15. Although there are many protocols for the conversion of a nitro compound to a ketone, most of those were not compatible with the functional groups of 15. Fortunately, Ti(III) was effective. Ce-mediated addition of the Grignard reagent 16 to the ketone followed by deprotection and protection then delivered the silyl ether 17. Remarkably, the ketone 17 could be deprotonated and carried on to the enol triflate 18 without eliminating the TMSO group. Coupling with the stannane 19 then completed the synthesis of manzamine A 4. One-carbon homologation of 18 led to ircinol A, ircinal A, and methyl ircinate (not illustrated).
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Hof, K., K. M. Lippert, and P. R. Schreiner. "Nitro-Mannich/Aza-Henry Reaction of Nitroalkanes with Imines." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00239.

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Hof, K., K. M. Lippert, and P. R. Schreiner. "Nitro-Mannich/Aza-Henry Reaction of Nitroacetates with Imines." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00241.

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