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Journal articles on the topic 'Novel Flavone Glycoside'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Soriano, I. R., R. E. Asenstorfer, O. Schmidt, and I. T. Riley. "Inducible Flavone in Oats (Avena sativa) Is a Novel Defense Against Plant-Parasitic Nematodes." Phytopathology® 94, no. 11 (2004): 1207–14. http://dx.doi.org/10.1094/phyto.2004.94.11.1207.

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The induction of defense compounds in oats (Avena sativa) in response to invasion by parasitic nematodes and to application of the wound hormone methyl jasmonate was examined. Oats cv. Quoll seedlings were challenged with Pratylenchus neglectus, Heterodera avenae, and Ditylenchus dipsaci and treated with 1 × 10-4 M methyl jasmonate. Three compounds, isolated in methanolic root and shoot extracts of oats, exhibiting an absorbance spectrum typical of flavone glycosides, were induced by nematode invasion and methyl jasmonate. These were identified as flavone-C-glycosides by mass spectrometry. The

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2

Reddy, Nimmanapalli P., Bandi A. K. Reddy, Duvvuru Gunasekar, Alain Blond, Bernard Bodo, and Reddy V. Raju. "A Novel Acylated Flavone Glycoside from Andrographis nallamalayana." Natural Product Communications 2, no. 5 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200512.

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A new acylated flavone glycoside, skullcapflavone I 2′- O-β-D-(6″- E-cinnamoyl) glucopyranoside (1), together with two known flavones, 5,2′-dihydroxy-7-methoxyflavone (2) and 5,2′,6′-trihydroxy-7-methoxyflavone-2′- O-β-D-glucopyranoside (3), and two known labdane diterpenoids, 14-deoxy-11,12-didehydroandrographolide (4) and andrographolide (5) were isolated from the whole plant of Andrographis nallamalayana. Structural elucidation of the new compound, as well as of the known compounds was achieved by various NMR techniques including 1H-1H COSY, HSQC, HMBC and ROESY experiments, ESITOF mass spe

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3

R.N., YADAVA, and BARSAINYA DEEPAK. "A Novel Flavone Glycoside from Centratherum anthelminticum Kuntze." Journal of Indian Chemical Society Vol. 74, Oct 1997 (1997): 822–23. https://doi.org/10.5281/zenodo.5900058.

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Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003 <em>Manuscript received 30 August 1996, accepted 19 December 1996</em> A Novel Flavone Glycoside from <em>Centratherum anthelminticum</em> Kuntze.

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4

R., N. Yadava, and Verma Abba. "Novel flavone glycoside from Ougeinia dalbergioides (Benth.)." Journal of Indian Chemical Society Vol. 84, Mar 2007 (2007): 303–6. https://doi.org/10.5281/zenodo.5816614.

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Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail</em> : rnyadava@rediffmail.com <em>Manuscript received 10 April 2006, revised 12 October 2006, accepted 2 February 2007</em> A novel flavone glycoside (m.p. 287-288 <sup>o</sup>C), C<sub>36</sub>H<sub>46</sub>O<sub>12</sub> [M]<sup>+</sup> 814 (FABMS), was obtained from ethyl acetate soluble fraction of the ethanolic .extract of the pods of <em>Ougeinia dalbergioides </em>(Benth.). It was characterized as 5,4'dihy droxy-3, 6, 7, 8-tetramethoxy fi a vone-5-<e

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5

R.N., YADAVA, and SINGH ABHA. "A Novel Flavone Glycoside from the Seeds of Crotalaria laburnifolia Linn." Journal of Indian Chemical Society Vol. 70, Mar 1993 (1993): 273. https://doi.org/10.5281/zenodo.5928169.

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Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003 <em>Manuscript received 30 January 1992, revised 12 October 1992, accepted 12 November 1992</em> A Novel Flavone Glycoside from the Seeds of Crotalaria laburnifolia Linn

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6

Yadava, R. N., and P. Tripathi. "A novel flavone glycoside from the stem of Bauhinia purpurea." Fitoterapia 71, no. 1 (2000): 88–90. http://dx.doi.org/10.1016/s0367-326x(99)00114-8.

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7

YADAVA, R. N., and D. BARSAINYA. "ChemInform Abstract: A Novel Flavone Glycoside from Centratherum anthelminticum Kuntze." ChemInform 29, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199839236.

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8

Yadava, R. N., and K. I. S. Reddy. "A novel prenylated flavone glycoside from the seeds of Erythrina indica." Fitoterapia 70, no. 4 (1999): 357–60. http://dx.doi.org/10.1016/s0367-326x(99)00048-9.

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9

Rakotovao, Marcelle, Bernard Voirin, Christine Bayet, Jean Favre-Bonvint та Marta Andriantsiferana. "3′-O-β-xylosyltricetin, a novel flavone glycoside from Trema humbertii". Phytochemistry 27, № 8 (1988): 2655–56. http://dx.doi.org/10.1016/0031-9422(88)87037-7.

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10

Wu, Jiumn-Yih, Tzi-Yuan Wang, Hsiou-Yu Ding, Yun-Rong Zhang, Shu-Yuan Lin, and Te-Sheng Chang. "Enzymatic Synthesis of Novel Vitexin Glucosides." Molecules 26, no. 20 (2021): 6274. http://dx.doi.org/10.3390/molecules26206274.

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Vitexin is a C-glucoside flavone that exhibits a wide range of pharmaceutical activities. However, the poor solubility of vitexin limits its applications. To resolve this limitation, two glycoside hydrolases (GHs) and four glycosyltransferases (GTs) were assayed for glycosylation activity toward vitexin. The results showed that BtGT_16345 from the Bacillus thuringiensis GA A07 strain possessed the highest glycosylation activity, catalyzing the conversion of vitexin into new compounds, vitexin-4′-O-β-glucoside (1) and vitexin-5-O-β-glucoside (2), which showed greater aqueous solubility than vit

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11

Dar, Arshed Iqbal, Gangaram Masar, Vikram Jadhaw, S. K. Bansal, and R. C. Saxena. "Isolation and structural elucidation of the novel flavone glycoside from Feronia limonia L." Journal of Pharmacy Research 7, no. 8 (2013): 697–704. http://dx.doi.org/10.1016/j.jopr.2013.04.058.

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12

K. Carte', Brad, Steven Carr, Charles DeBrosse, et al. "Aciculatin, a novel flavone-C-glycoside with DNA binding activity from chrysopogon aciculatis." Tetrahedron 47, no. 10-11 (1991): 1815–22. http://dx.doi.org/10.1016/s0040-4020(01)96096-x.

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13

CARTE, B. K., S. CARR, C. DEBROSSE, et al. "ChemInform Abstract: Aciculatin, a Novel Flavone-C-glycoside with DNA Binding Activity from Chrysopogon aciculatis." ChemInform 22, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199124256.

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14

Zhao, Xiaotong, Junjun Liu, Zhiyou Wen, et al. "The pharmacokinetics and tissue distribution of coumaroylspinosin in rat: A novel flavone C-glycoside derived from Zizyphi Spinosi Semen." Journal of Chromatography B 1046 (March 2017): 18–25. http://dx.doi.org/10.1016/j.jchromb.2017.01.030.

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15

Li, Bin-Chun, Bingbing Wu, Xueting Hou та Guo-Bin Ding. "Substrate Selectivities of GH78 α-L-Rhamnosidases from Human Gut Bacteria on Dietary Flavonoid Glycosides". Molecules 30, № 5 (2025): 980. https://doi.org/10.3390/molecules30050980.

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α-L-rhamnosidases play a key role in the metabolism and biodegradation of dietary flavonoid glycosides. We have developed a novel microplate spectrophotometric method to rapidly evaluate the conversion rates and substrate selectivities of mesophilic α-L-rhamnosidases towards citrus flavanone diglycosides by combining with a high-active and thermophilic β-D-glucosidase based on UV-visible spectral differences between citrus flavanone diglycosides and the corresponding aglycones under alkaline conditions. Furthermore, catalytic activities and enzyme kinetics of four α-L-rhamnosidases from human

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16

R.N., YADAVA, MATHEWS SUNUR. та JAIN NEERU. "Naringenin-4'-O-α-L-rhamnopyranoside: A Novel Flavanone Glycoside from the Stern of Crotαlαriα striαtα D.C." Journal of Indian Chemical Society Vol. 74, May 1997 (1997): 426–27. https://doi.org/10.5281/zenodo.5885968.

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Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003 <em>Manuscript received 9 August 1995, revised 29 December 1995. accepted 19 February 1996</em> Naringenin-4'-<em>O</em>-α-L-rhamnopyranoside: A Novel Flavanone Glycoside from the Stem of <em>Crotαlαriα striαtα</em> D.C.

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17

Wang, Tao, Fengjiao Zhang, Weibing Zhuang, Xiaochun Shu, and Zhong Wang. "Metabolic Variations of Flavonoids in Leaves of T. media and T. mairei Obtained by UPLC-ESI-MS/MS." Molecules 24, no. 18 (2019): 3323. http://dx.doi.org/10.3390/molecules24183323.

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The needles of Taxus species contain a large number of bioactive compounds, such as flavonoids. In the present study, the total flavonoid content in leaves of Taxus media and Taxus mairei was 19.953 and 14.464 mg/g, respectively. A total of 197 flavonoid metabolites (70 flavones, 42 flavonols, 26 flavone C-glycosides, 20 flavanones, 15 anthocyanins, 13 isoflavones, 6 flavonolignans, and 5 proanthocyanidins) were identified for the first time by a widely targeted Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS/MS) method within the two Taxus

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18

Chen, Yueyuan, Jiaoyang Dang, Xiaojie Yan, Fenglai Lu, and Dianpeng Li. "Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents." Journal of Chemistry 2020 (May 25, 2020): 1–9. http://dx.doi.org/10.1155/2020/7240535.

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Deep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides from Premna fulva Craib. DES-F, which was composed of choline chloride and 1,3-propanediol, showed the best extraction efficiency for the flavone di-C-glycosides, exceeding that of the conventional industrial solvent (40% ethanol). Subsequently, the extraction parameters for ultrasonic-assisted extr

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19

Dr., Harikant. "Flavonol Glycoside from Sida rhombifolia." Pharmaceutical and Chemical Journal 2, no. 2 (2015): 60–63. https://doi.org/10.5281/zenodo.13695165.

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A novel flavonol glycoside has been isolated from the ethyl acetate fraction of the stem bark of the <em>Sida rhombifolia</em>. The structure of the new compound has been established as 5, 7-dihydroxy-4'-methoxy flavonol-<em>3-O-β-D</em>-glucopyranoside based on the spectral data using UV, IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and Mass.

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20

Markham, Kenneth R., Rüdiger Mues, Marina Stoll, and H. Dietmar Zinsmeister. "NMR Spectra of Flavone Di-C-glycosides from Apometzgeria pubescens and the Detection of Rotational Isomerism in 8-C-Hexosylflavones." Zeitschrift für Naturforschung C 42, no. 9-10 (1987): 1039–42. http://dx.doi.org/10.1515/znc-1987-9-1006.

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1H and 13C NMR spectra are documented for the novel flavone-6,8-di-C-glycosides isolated from the liverwort, Apometzgeria pubescens. The existence of rotational isomerism evident from these spectra is shown to be general for 8-C-monohexosylflavones and of possible diagnostic value.

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21

Ni, Lin, Wei Huang, He-shan Wang, and Hui-you Xu. "Pogonatherumol, a Novel Highly Oxygenated Norsesquiterpene with Flavone C-Glycosides from Pogonatherum crinitum." Journal of Chemistry 2018 (August 23, 2018): 1–3. http://dx.doi.org/10.1155/2018/5029610.

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A novel highly oxygenated norsesquiterpene, pogonatherumol (1), with two known flavone C-glycosides (2-3), was isolated from Pogonatherum crinitum. The structure of the new compound was illuminated based on its spectroscopic data and X-ray analysis. Compounds 1 and 3 inhibited NO production in the mouse peritoneal macrophage (64.5 ± 7.2% and 61.6 ± 5.8%, respectively, at a concentration of 50 μM). The three compounds were inactive when tested against two human cancer cell lines (IC50 values > 50 μM).

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22

Li, Kun-Ping, Min Yuan, Chang-Le Liu, Ze-yu Liang, Tian-Ling Pan, and Jiao Guo. "Variations of Flavone Glycosides Profile Underscore the Necessity of Quality Control of Prepared Microctis Folium Slices." Evidence-Based Complementary and Alternative Medicine 2020 (November 26, 2020): 1–13. http://dx.doi.org/10.1155/2020/8887489.

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Microctis Folium (MF), the dried leaves of Microcos paniculata, is widely used as a medical and food dual-purpose herb in South-east Asia and China. However, the quality control of MF is not well studied. A simple and reliable quality control method was urgently needed for its growing usage. Herein, at first, its main active components were identified by UPLC-ESI-qTOF-MS, and a representative MF flavone glycosides profile consisting of ten compounds was illustrated, which is the most detailed one up to now. Successively, using vitexin as the reference substance, a novel QAMS method with HPLC f

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23

Mueed, Asad, Santosh Joshi, Sashank Agarwal, et al. "Isolation and characterization of novel flavan glycosides from Viscum angulatum B. Heyne ex DC. and screening for hypoglycemic activity." Annals of Phytomedicine : An International Journal 5, no. 2 (2016): 124–29. http://dx.doi.org/10.21276/ap.2016.5.2.17.

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24

R., N. Yadava, and lndra Sena Reddy K. "Novel bioactive flavonol glycoside from Desmodium gangeticum DC." Journal of Indian Chemical Society Vol. 80, Dec 2003 (2003): 1179–82. https://doi.org/10.5281/zenodo.5839915.

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Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gaur Univrsity, Sagar-470 003, India E-mail: rnyadava@rediffmail.com <em>Manuscript received 14 October 2003, revised 24 November 2003</em> A novel bioactive flavonol glycoside, m.p.<strong> 279-281"; C<sub>28</sub>H<sub>32</sub>O<sub>15</sub>, [M]<sup>+</sup> 608 (FABMS)</strong> has been isolated from the methanol soluble fraction of the stems of <em>Desmodium gangeticum</em> and its structure has been charactrerised as 3,5,7,4'-tetrahydroxy-8- methylllavone-3-<em>O</em>-α-L-rhamnopyranosyl-(1→6)-<em>O</em>-<

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25

Nguyen, Quang An, Hanh Trinh Van-Dufat, Sylvie Michel, François Tillequin, Vincent Dumontet, and Thierry Sévenet. "A New Phenylpropanoid Ester from the Bark of Zanthoxylum scandens (Rutaceae)." Zeitschrift für Naturforschung C 57, no. 11-12 (2002): 986–89. http://dx.doi.org/10.1515/znc-2002-11-1205.

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The alkaloids norchelerythrine, magnoflorine and (-)(S)-O-methylbalfourodinium cation were isolated from Zanthoxylum scandens bark collected in Vietnam, together with the flavanone glycoside hesperidin and the phenylpropanoids (E)-O-geranylconiferyl alcohol and (E)-O-geranylconiferyl alcohol (9Z, 12Z)-linoleate. This latter is a novel compound whose structure was elucidated on the basis of its spectral data and confirmed by chemical correlation.

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26

Chen, Yu-Jie, Guo-Yong Xie, Guang-Kai Xu, Yi-Qun Dai, Lu Shi, and Min-Jian Qin. "Chemical Constituents of Pyrrosia calvata." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000714.

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A novel flavanone glycoside, 3′,5′,5,7-tetrahydroxy-6- C- β-D-glucopyranosyl-flavanone (1), along with 16 known compounds, ( R/ S)-eriodictyol-8- C- β-D-glucopyranoside (2), quercetin-3- O- α-D-rhamnosyl (1′”→3′”)- β-D-glucopyranoside (3), hemipholin (4), 4 β-carboxymethyl-(-)-epicatechin methyl ester (5), kaempferol (6), quercetin (7), mangiferin (8), chlorogenic acid (9), 1,5- O-dicaffeoylquinic acid (10), 3,5- O-dicaffeoylquinic acid (11), 3- O-caffeoylquinic acid methyl ester (12), 1- O-caffeoyl glycoside (13), 4- O- β-D-glucopyranosyl-caffeic acid (14), 3′- O-methyleplcatechin-7- O- β-D-g

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27

Guo, Fengyu, Jie An, Minlong Wang та ін. "Inhibitory Mechanism of Quercimeritrin as a Novel α-Glucosidase Selective Inhibitor". Foods 12, № 18 (2023): 3415. http://dx.doi.org/10.3390/foods12183415.

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In this study, 12 flavonoid glycosides were selected based on virtual screening and the literature, and Quercimeritrin was selected as the best selective inhibitor of α-glucosidase through in vitro enzyme activity inhibition experiments. Its IC50 value for α-glucosidase was 79.88 µM, and its IC50 value for α-amylase >250 µM. As such, it could be used as a new selective inhibitor of α-glucosidase. The selective inhibition mechanism of Quercimeritrin on the two starch-digesting enzymes was further explored, and it was confirmed that Quercimeritrin had a strong binding affinity for α-glucosida

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28

Okpulor, S.U. "Physico-Chemical and Phytochemical Properties of Synbiotic Energy Bar Produced from Grains and Fruit." International Journal of Advanced Academic Research 10, no. 9 (2024): 1–11. https://doi.org/10.5281/zenodo.13768753.

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<em>The need for a different variety of nutritious and gut-friendly energy bar geared this research to explore the (physico-chemical and phytochemical properties of novel synbiotic energy bar formulated from blends of fonio, coconut, tigernut,  peanut, sesame seed and snot apple using gum arabic as binder while inulin was incorporated as prebiotic and fat replacer. The synbiotic energy bars were produced using the conventional method while inoculation, fermentation and sheeting were followed by vacuum drying and packaging. Physico-chemical properties shows  pH (5.11-5.81), water acti

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29

Quintin, Jérôme, and Guy Lewin. "Mild alkaline hydrolysis of some 7-O-flavone glycosides. Application to a novel access to rutinose heptaacetate." Tetrahedron Letters 46, no. 25 (2005): 4341–43. http://dx.doi.org/10.1016/j.tetlet.2005.04.085.

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30

de Oliveira, Ana P., Juliana S. Coppede, Bianca W. Bertoni та ін. "Costus spiralis (Jacq .) Roscoe : A Novel Source of Flavones with α -Glycosidase Inhibitory Activity". Chemistry & Biodiversity 15, № 1 (2017): e1700421. http://dx.doi.org/10.1002/cbdv.201700421.

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31

Kaur, Prabhjot, and Vikas Sharma. "Prospective Plant Based Anticancer Lead Molecules." Current Topics in Medicinal Chemistry 18, no. 30 (2019): 2567–83. http://dx.doi.org/10.2174/1568026619666181224101132.

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Nature has been a source of a wide range of products being utilized for the treatment of various diseases like malaria, cancer, diabetes etc. Among these, cancer is emerging as a leading cause of deaths worldwide and the development of cross-resistance to already established drugs increases the need for novel anticancer drugs. To discover novel anticancer molecules, it is a necessity to unearth the molecules which can act as anticancer agents. Taking natural products in vision, phytoconstituents like terpenoids, flavones, glycosides and alkaloids might act as a major source of lead molecules.

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32

Morita, Tokio, Takeshi Akiyoshi, Ryo Sato, et al. "Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides." Journal of Agricultural and Food Chemistry 68, no. 48 (2020): 14182–91. http://dx.doi.org/10.1021/acs.jafc.0c06132.

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33

HORI, KAZUYUKI, TOSHIKO SATAKE, YASUHISA SAIKI, NOBUTOSHI TANAKA, TAKAO MURAKAMI, and CHIU-MING CHEN. "Chemical and Chemotaxonomical Studies of Filices. LXXIV. : The Novel Flavanone Glycosides of Pyrrosia linearfolia (HOOK.) CHING." YAKUGAKU ZASSHI 108, no. 5 (1988): 417–21. http://dx.doi.org/10.1248/yakushi1947.108.5_417.

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34

Cyboran-Mikołajczyk, Sylwia, Dorota Bonarska-Kujawa, Katarzyna Męczarska, Agnieszka Krawczyk-Łebek, and Edyta Kostrzewa-Susłow. "Novel O-Methylglucoside Derivatives of Flavanone in Interaction with Model Membrane and Transferrin." Membranes 12, no. 10 (2022): 978. http://dx.doi.org/10.3390/membranes12100978.

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Flavonoids were biotransformed using various microorganisms, in order to obtain new compounds with potentially high biological activity. The aim of this work was to determine and compare the biological activity of four novel 6-methylflavanone O-methylglucosides. The tested compounds have the same flavonoid core structure and an attached O-methylglucose and hydroxyl group at different positions of ring A or B. The studies on their biological activity were conducted in relation to phosphatidylcholine membrane, erythrocytes and their membrane, and with human transferrin. These studies determined

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35

Bartella, Lucia, Fabio Mazzotti, Ilaria Santoro, Ines Rosita Talarico, and Leonardo Di Donna. "Direct Determination of Flavanone Isomers in Citrus Juice by Paper Spray Tandem Mass Spectrometry." Antioxidants 14, no. 1 (2024): 20. https://doi.org/10.3390/antiox14010020.

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A novel and efficient analytical protocol based on paper spray tandem mass spectrometry was developed for the determination of isomeric O-glycoside flavanones in citrus juices and beverages. This approach significantly reduces sample preparation time and solvent consumption compared to traditional chromatographic techniques. By exploiting the unique fragmentation patterns of these compounds, accurate quantification of both diglycosides and their individual isomers (neohesperidoside and rutinose derivatives) was achieved. The method demonstrated excellent analytical performance, with high accur

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36

Olennikov, Daniil N., and Nina I. Kashchenko. "Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential." Agronomy 13, no. 9 (2023): 2410. http://dx.doi.org/10.3390/agronomy13092410.

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Cucumber is an important agricultural crop that is cultivated under greenhouse conditions. Cucumber cultivation generates substantial quantities of green waste that require proper disposal. The lack of data on the chemical composition of cucumber greens and their biological activity emphasizes the necessity for research on useful products resulting from this widely available waste. Our examination of the flavonoid contents in the leaves and stems of 30 cucumber cultivars revealed 6 cultivars with high flavonoid contents. In addition, the cutting time did not cause negative effects, and we obse

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37

Chen, Mingjie, Zhenghua Du, Wenjie Yue, et al. "Metabolomic Analysis Provides Insights into Bud Paradormancy in Camellia sinensis cv. Huangdan." International Journal of Molecular Sciences 26, no. 11 (2025): 5094. https://doi.org/10.3390/ijms26115094.

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Bud paradormancy has been widely studied in perennial deciduous woody species, but little attention has been paid to paradormancy set and release in perennial evergreen tree species. Here, shoot bud paradormancy in Camellia sinensis cv. Huangdan was studied by untargeted metabolomics. We found that after removing the axillary floral buds for one day, the paradormancy of the axillary shoot buds was released. The paradormant shoot buds had lower glucose-1-phosphate, fructose, and D-(-)-tagatofuranose content but higher trehalose, raffinose, galactinol, and α-D-xylopyranose content. Meanwhile, hi

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38

Yadava, R. N., Sunu R. Mathews та Neeru Jain. "ChemInform Abstract: Naringenin-4′-O-α-L-rhamnopyranoside: A Novel Flavanone Glycoside from the Stem of Crotalaria striata D.C." ChemInform 30, № 50 (2010): no. http://dx.doi.org/10.1002/chin.199950209.

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39

Xiao, Yecheng, Fuhua Fu, Youhe Wei, Shuyun Shi, and Yang Shan. "Online Extraction–DPPH–HPLC-DAD-QTOF-MS System for Efficient Screening and Identification of Antioxidants from Citrus aurantium L. Var. amara (Rutaceae): Integrating Sample Preparation and Antioxidants Profiling." Antioxidants 11, no. 5 (2022): 1014. http://dx.doi.org/10.3390/antiox11051014.

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The lack of a direct connection between solid edible or medical natural products and bioactive compound profiling is a bottleneck in natural product research and quality control. Here, a novel integrated system, online extraction (OLE)–2,2′-diphenyl-1-picrylhydrazyl (DPPH)–HPLC-DAD-QTOF-MS, was fabricated to extract, screen, and identify antioxidants from the whole fruit of Citrus aurantium L. var. amara (CAVA, Rutaceae) simply, rapidly, and efficiently. The system consumes less sample (1.0 mg of CAVA powder) and requires a shorter analytical time (45 min for sample extraction, antioxidants sc

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Aumeeruddy, Muhammad Zakariyyah, and Mohamad Fawzi Mahomoodally. "Ethnomedicinal Plants for the Management of Diabetes Worldwide: A Systematic Review." Current Medicinal Chemistry 28, no. 23 (2021): 4670–93. http://dx.doi.org/10.2174/0929867328666210121123037.

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Background: The increasing incidence of diabetes worldwide has urged researchers to explore novel antidiabetic agents from natural products. Ethnomedicinal field studies on diabetes have expanded across the globe, documenting large numbers of folk medicinal plants against diabetes. Nonetheless, a systematic review of these surveys has not been conducted so far. This study documents the medicinal plants traditionally used globally for managing diabetes. Methods: Key databases including Sciencedirect, Medline/PubMed, and Google Scholar were scrutinized. The Plant List and The International Plant

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Panda, Subhamay, and Iman Ehsan. "MOLECULAR DOCKING STUDIES OF SNAKE VENOM SERINE PROTEASE OF SHARP-NOSED PIT VIPER WITH HESPERETIN." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (2018): 457. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.25531.

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Objective: The management of snake bite envenomation is a global challenge affecting millions of people. Immunotherapy is still regarded as the treatment of choice; however, their subsequent adverse effects restrict their potential use for therapy against snake venom poisoning. In recent years, more attention has been given to the exploration of indigenous medicinal plants for their outstanding benefits for the treatment of several diseases and disorders, including snake venom poisoning. Hesperetin is a naturally occurring compound derived from a flavanone glycoside, hesperidin and is obtained

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Ming, Shanxiu, Shuyi Li, Zhe Chen, et al. "Bioinspired Lipase Immobilized Membrane for Improving Hesperidin Lipophilization." Antioxidants 11, no. 10 (2022): 1906. http://dx.doi.org/10.3390/antiox11101906.

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Lipophilization is a promising way to improve the bioavailability of flavonoids. However, the traditional enzymatic esterification methods are time-consuming, and present low yields and purity. Herein, a novel membrane-based lipophilization technology—bioinspired lipase immobilized membranes (BLIMs), including CAL-B@PES, CAL-B@PDA/PES and GA/CAL-B@PDA/PES— were fabricated to improve the antioxidant flavanone glycoside hesperidin lipophilization. Via reverse filtration, PDA coating and GA crosslinking, Candida antarctica lipase B (CAL-B) was stably immobilized on membrane to fabricate BLIMs. Am

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Chen, Chuying, Jinyin Chen, and Chunpeng Wan. "Pinocembrin-7-Glucoside (P7G) Reduced Postharvest Blue Mold of Navel Orange by Suppressing Penicillium italicum Growth." Microorganisms 8, no. 4 (2020): 536. http://dx.doi.org/10.3390/microorganisms8040536.

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The current study aimed to examine the in vitro and in vivo antifungal potential of pinocembrin-7-glucoside (P7G). P7G is an antifungal flavanone glycoside isolated from Ficus hirta Vahl. fruit against Penicillium italicum, a causative pathogen of blue mold disease in citrus fruit, and this study elucidates its possible action mechanism. P7G had a prominent mycelial growth inhibitory activity against P. italicum, with an observed half maximal effective concentration, minimum inhibitory concentration and minimum fungicidal concentration of 0.08, 0.2, and 0.8 g/L, respectively. The data from the

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Gevrenova, Reneta, Gokhan Zengin, Kouadio Ibrahime Sinan, et al. "UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey." Antioxidants 10, no. 8 (2021): 1180. http://dx.doi.org/10.3390/antiox10081180.

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In the current study, Achillea santolinoides and Achillea aleppica aeral parts and root were extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were obtained using UHPLC-MS, yielding the identification of hydroxybenzoic and hydroxycinnamic acids, phenolic acid glycosides and sugar esters, acylquinic acids, O-glycosyl flavones and flavonols, and flavonoid aglycons, among others. The antioxidant properties and enzyme inhibitory activities of the extracts were assayed with in vitro tests. The phenolic content of the water extracts was significantly higher as compar

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Sunstrum, Frederick G., Hannah L. Liu, Sharon Jancsik, Lufiani L. Madilao, Joerg Bohlmann, and Sandra Irmisch. "4-Coumaroyl-CoA ligases in the biosynthesis of the anti-diabetic metabolite montbretin A." PLOS ONE 16, no. 10 (2021): e0257478. http://dx.doi.org/10.1371/journal.pone.0257478.

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Background Montbretins are rare specialized metabolites found in montbretia (Crocosmia x crocosmiiflora) corms. Montbretin A (MbA) is of particular interest as a novel therapeutic for type-2 diabetes and obesity. There is no scalable production system for this complex acylated flavonol glycoside. MbA biosynthesis has been reconstructed in Nicotiana benthamiana using montbretia genes for the assembly of MbA from its various different building blocks. However, in addition to smaller amounts of MbA, the therapeutically inactive montbretin B (MbB) was the major product of this metabolic engineerin

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Łój, Daniel, Tomasz Janeczko, Agnieszka Bartmańska, Ewa Huszcza, and Tomasz Tronina. "Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi." International Journal of Molecular Sciences 25, no. 19 (2024): 10433. http://dx.doi.org/10.3390/ijms251910433.

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Xanthohumol (1) is a major prenylated flavonoid in hops (Humulus lupulus L.) which exhibits a broad spectrum of health-promoting and therapeutic activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer effects. However, due to its lipophilic nature, it is poorly soluble in water and barely absorbed from the gastrointestinal tract, which greatly limits its therapeutic potential. One method of increasing the solubility of active compounds is their conjugation to polar molecules, such as sugars. Sugar moiety introduced into the flavonoid molecule significantly increases

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Elboutachfaiti, Redouan, Roland Molinié, David Mathiron, et al. "Secondary Metabolism Rearrangements in Linum usitatissimum L. after Biostimulation of Roots with COS Oligosaccharides from Fungal Cell Wall." Molecules 27, no. 7 (2022): 2372. http://dx.doi.org/10.3390/molecules27072372.

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In vitro culture of flax (Linum usitatissimum L.) was exposed to chitosan oligosaccharides (COS) in order to investigate the effects on the growth and secondary metabolites content in roots and shoots. COS are fragments of chitosan released from the fungal cell wall during plant–pathogen interactions. They can be perceived by the plant as pathogen-associated signals, mediating local and systemic innate immune responses. In the present study, we report a novel COS oligosaccharide fraction with a degree of polymerization (DP) range of 2–10, which was produced from fungal chitosan by a thermal de

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Gbolo, Benjamin Z., K. N. Ngbolua, Bobette N. Ciala, et al. "LC-MS/MS Analysis of crude Flavonoid Compounds from <i>Justicia secunda</i> from Democratic Republic of the Congo and evaluation of their antisickling Activity." Natural Resources for Human Health 4, no. 4 (2024): 387–97. http://dx.doi.org/10.53365/nrfhh/192594.

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<i>Justicia secunda</i> Vahl (Acanthaceae) is a tropical herbaceous plant traditionally used by indigenous peoples of the Democratic Republic of the Congo (DRC) to treat symptoms associated with sickle cell disease (SCD), a genetic condition with life-threatening complications. Given the lack of side-effect-free drugs, alternative herbal therapies that can reduce or reverse red blood cell sickling may serve as safe and effective treatments. The primary objective of this study is to conduct a phytochemical screening of crude flavonoids extracted from <i>J. secunda</i> us

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Benarba, Bachir, Atanasio Pandiella, and Almahy Elmallah. "Anticancer activity, phytochemical screening and acute toxicity evaluation of an aqueous extract of Aristolochia longa L." International Journal of Pharmaceutical and Phytopharmacological Research 6, no. 1 (2017): 20. http://dx.doi.org/10.24896/eijppr.2016614.

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Aristolochia longa (Aristolochiaceae) is widely used in traditional medicine. The present study was carried out to investigate the cytotoxic activity and the acute toxicity of an aqueous extract of A. longa roots. Also, the phytochemical composition of the extract was evaluated. The cytotoxic effects of the aqueous extract in triple negative breast cancer MDA-MB-231 and HBL-100 cell lines was evaluated by MTT assay. A. longa roots were screened for the presence of phytochemical constituents using the standard qualitative phytochemical procedures. The acute oral toxicity (5000 mg/kg limited dos

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Michlmayr, Herbert, Walter Brandes, Reinhard Eder, Christina Schümann, Andrés M. del Hierro та Klaus D. Kulbe. "Characterization of Two Distinct Glycosyl Hydrolase Family 78 α-l-Rhamnosidases from Pediococcus acidilactici". Applied and Environmental Microbiology 77, № 18 (2011): 6524–30. http://dx.doi.org/10.1128/aem.05317-11.

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ABSTRACTα-l-Rhamnosidases play an important role in the hydrolysis of glycosylated aroma compounds (especially terpenes) from wine. Although several authors have demonstrated the enological importance of fungal rhamnosidases, the information on bacterial enzymes in this context is still limited. In order to fill this important gap, two putative rhamnosidase genes (ramandram2) fromPediococcus acidilacticiDSM 20284 were heterologously expressed, and the respective gene products were characterized. In combination with a bacterial β-glucosidase, both enzymes released the monoterpenes linalool andc

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