Log in

Relevant bibliographies by topics / Nucleoside phosphorylases / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Nucleoside phosphorylases.

Dissertations / Theses on the topic 'Nucleoside phosphorylases'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 23 dissertations / theses for your research on the topic 'Nucleoside phosphorylases.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Visser, Daniel Finsch. "Isolation and evolution of novel nucleoside phosphorylases." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1004031.

Full text

Abstract:

Approximately 33.4 million people are living with HIV/AIDS. Of those, 97% live in low and middle income countries, with 22.4 million in sub-Saharan Africa. Only 42% of the people who require anti-retrovirals (ARVs) in low to middle income countries are receiving anti-retroviral therapy (ART). There is a need to develop novel and cost effective methods for producing antiretroviral drugs. Stavudine and azidothymidine (AZT) were identified as potential targets because they could both be produced through a common intermediate – 5 methyluridine (5-MU). It has been established that the biocatalytic

APA, Harvard, Vancouver, ISO, and other styles

2

Rabuffetti, M. "PURINE NUCLEOSIDE PHOSPHORYLASES AS BIOCATALYSTS AND PHARMACOLOGICAL TARGETS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/481437.

Full text

Abstract:

A purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP) was successfully exploited to catalyze the “one-pot, one-enzyme” regio- and stereoselective transfer of β-D-ribose from a proper sugar donor (7-methylguanosine iodide) to a library of 6-substituted purine acceptors, resulting in the “in batch” synthesis of 24 ribonucleosides. Transglycosylation conversions confirmed the broad tolerance and the potential of AhPNP as biocatalyst, providing the necessary information to undertake the preparative synthesis of 6-modified purine nucleosides. [1] AhPNP was then immobilized in a stain

APA, Harvard, Vancouver, ISO, and other styles

3

Szeker, Kathleen [Verfasser], and Peter [Akademischer Betreuer] Neubauer. "Nucleoside phosphorylases from thermophiles - recombinant expression and biocatalytic use for modified nucleosides / Kathleen Szeker. Betreuer: Peter Neubauer." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2012. http://d-nb.info/102648362X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kaspar, Felix [Verfasser], Peter [Akademischer Betreuer] Neubauer, Peter [Gutachter] Neubauer, Jens [Gutachter] Kurreck, and Frank [Gutachter] Hollmann. "Analytical methods and thermodynamic frameworks for efficient biocatalytic nucleoside synthesis via nucleoside phosphorylases / Felix Kaspar ; Gutachter: Peter Neubauer, Jens Kurreck, Frank Hollmann ; Betreuer: Peter Neubauer." Berlin : Technische Universität Berlin, 2021. http://d-nb.info/1238141420/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Zhou, Xinrui [Verfasser], Peter [Akademischer Betreuer] Neubauer, Igor A. [Akademischer Betreuer] Mikhailopulo, Roland [Akademischer Betreuer] Wohlgemuth, and Vera [Akademischer Betreuer] Meyer. "Thermostable nucleoside phosphorylases as biocatalysts for the synthesis of purine nucleoside analogues / Xinrui Zhou. Gutachter: Peter Neubauer ; Igor A. Mikhailopulo ; Roland Wohlgemuth ; Vera Meyer. Betreuer: Peter Neubauer ; Igor A. Mikhailopulo." Berlin : Technische Universität Berlin, 2014. http://d-nb.info/1067385991/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Marr, Clara Lok-Po. "Studies on human nucleoside phosphorylase." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316743.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Souza, Juliana Roberta Torini de. "Caracterização estrutural e funcional de duas Nucleosídeo Fosforilases de Schistosoma mansoni." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-26102016-153439/.

Full text

Abstract:

As doenças parasitárias são uma das maiores causas de morte em países em desenvolvimento, e recebem pouca ou nenhuma atenção das indústrias farmacêuticas para o desenvolvimento de terapias. Causada pelo parasita Schistosoma mansoni a esquistossomose mansônica afeta aproximadamente 259 milhões de pessoas no mundo sendo aproximadamente 6 milhões somente no Brasil. O S. mansoni não possui a via \"de novo\" para a biossíntese de bases púricas e depende integralmente da via de salvação para o suprimento dessas bases, portanto, essa via é um alvo em potencial. Agentes capazes de bloquear a atividade

APA, Harvard, Vancouver, ISO, and other styles

8

Silva, Diego Oliveira Nolasco da [UNESP]. "Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/87508.

Full text

Abstract:

Made available in DSpace on 2014-06-11T19:22:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-08-18Bitstream added on 2014-06-13T20:29:19Z : No. of bitstreams: 1 silva_don_me_sjrp.pdf: 1054782 bytes, checksum: 832047dd271670cc0bc6debdbd5dc8d8 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das purinas, normalmente operando na via de recuper

APA, Harvard, Vancouver, ISO, and other styles

9

Kavianipour, Mohammad. "Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism." Doctoral thesis, Umeå University, Public Health and Clinical Medicine, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14.

Full text

Abstract:

<p>Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). Today, much is known about the signalling pathways involved in IP; however, the details of the final steps leading to cardioprotection, remain elusive. Adenosine (a catabolite of ATP) plays a major role in the signalling pathways of IP. Following IP there is an unexplained discrepancy between an increased adenosine production (evidenced by increased 5’-nucleotidase activity) and the successive

APA, Harvard, Vancouver, ISO, and other styles

10

Rule, S. A. R. "Synchrotron X-radiation protein crystallography and its use in the crystal structure determination of purine nucleoside phosphorylase." Thesis, Keele University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235339.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Kamel, Hassan Sarah [Verfasser], Peter [Akademischer Betreuer] Neubauer, Peter [Gutachter] Neubauer, Antje [Gutachter] Spieß, and Jens [Gutachter] Kurreck. "Enzymatic Synthesis of alpha-D-Pentofuranose -1- Phosphate as a universal glycosyl donor for modified nucleosides synthesis using thermostable nucleoside phosphorylase / Sarah Kamel Hassan ; Gutachter: Peter Neubauer, Antje Spieß, Jens Kurreck ; Betreuer: Peter Neubauer." Berlin : Technische Universität Berlin, 2019. http://d-nb.info/120207121X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Silva, Diego Oliveira Nolasco da. "Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis /." São José do Rio Preto : [s.n.], 2005. http://hdl.handle.net/11449/87508.

Full text

Abstract:

Orientador: Walter Filgueira de Azevedo Júnior<br>Banca: Luis Fernando Delboni<br>Banca: Fernanda Canduri<br>Resumo: A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das purinas, normalmente operando na via de recuperação do DNA das células. Mais ainda, a PNP cliva ligações glicosídicas com inversão da configuração para produzir a-ribose 1-fosfato. Acredita-se que no organismo do Mycobacterium tuberculosis a PNP desempenha tarefas

APA, Harvard, Vancouver, ISO, and other styles

13

Monsalve, Monica Soto. "Determinação estrutural por difração de raios X de pirrolidinas poliidroxiladas com potencial atividade inibidora de purina nucleosídeo fosforilase." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-02102017-145525/.

Full text

Abstract:

Foram determinadas por meio de difração de raios x as estruturas de cinco compostos azaçúcares. Foram estudadas as interações envolvidas na formação das redes cristalinas em cada um dos compostos analisados. Foi encontrado que nos compostos azaçúcares estudados, as interações principais são as ligações de hidrogênio do tipo C-H···O e C-H···π. Este comportamento foi verificado usando ferramentas como as superfícies de Hirshfeld e os gráficos de impressão digital. Realizou-se o estudo de docking molecular dos compostos azaçúcares com respeito à enzima purina nucleosídeo fosforilase (PNP). Foi

APA, Harvard, Vancouver, ISO, and other styles

14

Massenzio, Francesca <1989&gt. "Physiopathological Protein Release by Glial Cells: Focus on Purine Nucleoside Phosphorylase (PNP), Superoxide Dismutase 1 (SOD1) and α-Synuclein". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/8081/7/TESI%20Dottorato%20Francesca%20Massenzio.pdf.

Full text

Abstract:

The interest on Purine Nucleoside Phosphorylase (PNP), Superoxide Dismutase 1 (SOD1) and α-synuclein derived from the fact that they are all involved in brain neuropathology.Mutations in the gene codifying for PNP induce PNP deficiency, a neurodevelopmental disorder characterized by immunodeficiency; SOD1 and alpha-synuclein are involved in amyotrophic lateral sclerosis and Parkison’s disease respectively, both characterized by the presence of protein aggregates, neurodegeneration and neuroinflammation. Because in all these neurological diseases there is a strong involvement of immune cells,

APA, Harvard, Vancouver, ISO, and other styles

15

Alvarez, Frédéric. "Synthèse de dérivés benzimidazole-4,7-diones et imidazo[4,5-g]quinoléine-4,9 diones, inhibiteurs potentiels de la purine nucléoside phosphorylase issue de Toxoplasma gondii." Lyon 1, 2002. http://www.theses.fr/2002LYO1T197.

Full text

Abstract:

La 4e de couverture indique : "La toxoplasmose est une maladie parasitaire dont l'agent infectieux est Toxoplasma gondii. La purine nucléoside phosphorylase (PNP), une enzyme prenant part au métabolisme des purines, est essentielle au développement de ce parasite. Après une analyse des données de la littérature concernant les inhibiteurs connus de PNP, il nous a semblé intéressant de mettre au point des voies d'accès à de nouveaux inhibiteurs potentiels, de la famille des 2,3-dihydrobenzimidazole-4,7-diones, des benzimidazole-4,7-diones et des imidazo[4,5-g]quinoléine-4,9-diones. Dans le cas d

APA, Harvard, Vancouver, ISO, and other styles

16

Martins, Nádia Helena 1982. "Estudos estruturais e biofísicos da enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317143.

Full text

Abstract:

Orientador: Mário Tyago Murakami<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T16:32:04Z (GMT). No. of bitstreams: 1 Martins_NadiaHelena_D.pdf: 33217097 bytes, checksum: 6cbd9ad5dcfddd06e2357b3c680cd3f6 (MD5) Previous issue date: 2011<br>Resumo: A enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis (BsPNP233) c uma nucleosídeo fosforilase do tipo 1 , responsável pela catalise reversível da reação de guebra de urn nucleosídeo em base nitrogenada e ribose-1-fosfato na via de salvação de purinas. Essa e

APA, Harvard, Vancouver, ISO, and other styles

17

Vodnala, Munender. "Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80904.

Full text

Abstract:

Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs. T. brucei lacks de novo synthesis of purine nucleosides; hence it depends on the host to make its purine nucleotides. T. brucei has a high affinity adenosine kinase (TbAK), which phosphorylates adenosine, deoxyadenosine (dAdo), inosine and their analogs. RNAi experiments confirmed that TbAK is responsible for the salvage of dAdo and the toxicit

APA, Harvard, Vancouver, ISO, and other styles

18

Aono, Riku. "Studies on nucleotide and pentose metabolism in Archaea." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/200451.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Giessmann, Robert Tobias [Verfasser], Peter [Akademischer Betreuer] Neubauer, Peter [Gutachter] Neubauer, Udo [Gutachter] Kragl, and Maria Andrea [Gutachter] Mroginski. "Prediction of kinetics and yields of nucleoside phosphorylase reactions and derived enzymatic reaction cascades / Robert Tobias Giessmann ; Gutachter: Peter Neubauer, Udo Kragl, Maria Andrea Mroginski ; Betreuer: Peter Neubauer." Berlin : Technische Universität Berlin, 2020. http://d-nb.info/1220774537/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Browning, Luke Wayne. "StCKP and potato tuber dormancy." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275074.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Ranjbarian, Farahnaz. "Targets and strategies for drug development against human African sleeping sickness." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131074.

Full text

Abstract:

Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. There is a great need for new medicines against the disease and specific properties of nucleoside kinases in the pathogen can be exploited as targets for chemotherapy. T. brucei contains a gene where two thymidine kinase sequences are fused into a single open reading frame. These types of tandem thymidine kinases were found only in different types of parasites, which made us to believe that it might be ben

APA, Harvard, Vancouver, ISO, and other styles

22

Papinazath, Taniya. "The Effects of Purine Nucleoside Phosphorylase (PNP) Deficiency on Thymocyte Development." Thesis, 2010. http://hdl.handle.net/1807/24616.

Full text

Abstract:

PNP is a crucial enzyme in purine metabolism, and its inherited defects result in severe T-lineage immune deficiency in humans. I hypothesized that PNP deficiency disrupts the development of late CD4-CD8- double negative (DN) thymocytes and induces mitochondrial-mediated apoptosis of CD4+CD8+ double positive (DP) thymocytes. By using PNP-deficient (PNP-/-) mice as well as an OP9-DL1 co-culture system simulating PNP-deficient conditions, I demonstrated that PNP deficiency interferes with the maturation of DN thymocytes at the transition from DN3 to DN4 stage. Although PNP deficiency does not

APA, Harvard, Vancouver, ISO, and other styles

23

Ting, Jing-Wen, and 丁靜雯. "Characterization of purine nucleoside phosphorylase and deoxyuridine pyrophosphatase genes of an Iridovirus from yellow grouper Epinephelus awoara." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/64127806765100394046.

Full text

Abstract:

博士<br>國防醫學院<br>生命科學研究所<br>94<br>Part I: Studies of the Purine Nucleoside Phosphorylase Gene from Grouper Iridovirus 英文摘要 Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway. It catalyses the reversible phosphorolysis of purine (2'-deoxy)ribonucleosides to free bases and (2'-deoxy)ribose 1-phosphates. A novel piscine viral PNP gene from grouper iridovirus (GIV), a causative agent of an epizootic fish disease, is reported. The putative GIV PNP gene encodes a protein of 285 amino acids with a predicted molecular mass of 30,332 Da. A high similarity between this GIV

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!