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Dissertations / Theses on the topic 'Object of regulation'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Desiatnikov, Alexander. "Emotion regulation in adolescents : influences of social cognition and object relations : an ERP study." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1449453/.

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Aims: The use of emotion regulation strategies can reduce the intensity of negative experiences; event related potentials (ERP) specifically the late positive potential (LPP) is known to be sensitive to this reduction in adults. It is argued that individual differences play an important role in one‘s ability to regulate emotions. The current study aimed to explore neural correlates of emotion regulation in adolescents. The study aimed to replicate previous findings from studies on adult populations, to show that emotion regulation is associated with changes in the amplitude of the late positiv

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2

DeVincentis, Rosalyn D. "A Dynamic Exploration into Mentalization Among Youth on the Autism Spectrum." Antioch University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1534172288409853.

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Мордань, Євгенія Юріївна, Евгения Юрьевна Мордань та Yevheniia Yuriivna Mordan. "Об’єктне поле регулювання банківської системи на мікрорівні". Thesis, Львівський інститут банківської справи Національного банку України, 2014. http://essuir.sumdu.edu.ua/handle/123456789/53605.

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Виявлено сутність банківської системи відповідно до інституційного і системного підходів і сформовано об'єкт регулювання банківської системи на мікрорівні. Доведено необхідність індивідуального регулювання системно значимих банків, тому що їх вихід з ринку може зробити істотний негативний вплив на банківську систему і економіку.<br>Revealed the essence of the banking system according to the institutional and systemic approaches and formed the object of the banking system regulation at the micro-level. Proved the necessity of individual regulation of systemically important banks, because their

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Folke-Fichtelius, Maria. "Förskolans formande : Statlig reglering 1944–2008." Doctoral thesis, Uppsala University, Department of Education, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9276.

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<p>Preschool is a central part of Swedish family life. The manner in which the state regulates preschool through laws, ordinances, and various kinds of written objectives has an impact on many people in the Swedish society. </p><p>The thesis examines the development of preschool state regulation from the 1940s until 2008. The starting point of the study is a draft for a new Education Act, put forward in 2003, which proposed that preschool should be integrated into the school system as a new form of school. The purpose of the study is to generate knowledge about the state regulation of Swedish

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5

Bachelart, Maximilien. "La relation médecin-patient en consultation douleur : dynamique de l'alliance thérapeutique comme perspective au changement." Thesis, Dijon, 2013. http://www.theses.fr/2013DIJOL004.

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L’objectif est de comprendre comment se forme et se rompt l’alliance thérapeutique dans des consultations médicales pour la douleur chronique. Notre population se compose de quarante-deux patients consultants pour la première fois en Centre d’Etude et de Traitement de la Douleur. Les patients ont été évalués durant les cinq premières consultations et une grille des cognitions sociales et relations d’objet a été remplie. La perception de la douleur, l’autorégulation et l’observance médicamenteuse ont été évaluées. Un questionnaire d’alliance thérapeutique a été rempli par le médecin et les pati

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6

Slovák, Zdeněk. "Vytápění polyfunkčního objektu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2014. http://www.nusl.cz/ntk/nusl-226865.

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This thesis deals with the design of the heating system in a Polyfunctional building. The design is solving heating of a Polyfunctional Object in Kostelec nad Ohří. The building has basement and two floors. The building is heated by means of panel, tubular and floor convector heaters. The source of the heat is located in the boiler room in the basement.

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Kmeť, Peter. "Obchodní a administrativní centrum Poděbradská - stavebně technologický projekt." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409933.

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This diploma thesis focuses on construction technology preparation of shopping center in Prague 9, Vysočany. The aim of this work was to choose an appropriate construction process. The thesis contains general information about construction with construction technology project, its financial and time consuming, facilities for construction and traffic situation in the surroundings of the construction, design of main machinery and mechanisms, technological regulation with control and test plan. The diploma thesis is focused on piles realization.

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Tarun, Akansha. "Hydrogen Sulfide (H2S) as a regulator of myocardial redox state and the redox-sensitive regulation of cystathionine γ-lyase (CSE)". Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:d866892d-ed0c-4995-b8c2-5c71657e7774.

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In advanced stages, cardiac disease causes millions of deaths each year. Superoxide anions (O<sub>2</sub><sup>.-</sup>) and their derivative peroxynitrite (ONOO<sup>-</sup>) contribute to cardiac disease pathogenesis, yet strategies to reduces these reactive oxygen species through antioxidants in large scale clinical trials have largely been unsuccessful. Better understanding of pathways regulating enzymatic sources of O<sub>2</sub><sup>.-</sup> like NADPH oxidases, uncoupled nitric oxide synthases (NOSs) and mitochondrial oxidases are required to regulate myocardial oxidative stress in patien

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Spottiswoode, Natasha. "Hepcidin regulation in malaria." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:ea5646aa-9c64-4158-9de8-1d6b7fc9d41d.

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Epidemiological observations have linked increased host iron with malaria susceptibility. At the same time, blood-stage malaria infection is associated with potentially life-threatening anemia. To improve our understanding of these relationships, this work presents an examination of the mechanisms controlling the upregulation of the hormone hepcidin, the master regulator of iron metabolism, in malaria infection. Chapter 2 presents data from a mouse model of malaria infection which indicate that hepcidin upregulation in malaria infection is associated with increased activity of the sons of moth

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Demetriou, Philippos. "Regulation of T cell activation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:a20d2d22-bdc8-407e-a9b5-57d18ae6948a.

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Recognition of a cognate peptide-MHC molecule by its T cell receptor (TCR) triggers a critical cascade of protein re-organisation and clustering at the cell interface. This results in the formation of the immunological synapse (IS), concurrent with and influencing T cell activation. The glycoprotein CD2 with its ligand CD48 (mouse) or CD58 (human) has been shown to act as an important adhesion/co-stimulatory molecule influencing the T cell activation. While initial analysis of the knockout mouse revealed redundancy with LFA-1 and CD28, activity of this pathway has been correlated with enhanced

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Nacvalovaite, Ana. "Regulation of sovereign wealth funds." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:c6957aef-601d-41c3-b352-d086e7f025af.

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This thesis analyses the motivations, behaviours and outcomes of Sovereign Wealth Funds (SWFs), and the regulations pertaining to them. The motivation for examining these issues includes the growing role of SWFs as large investors in a wide range of global asset classes, their continued resistance to transparency, and the perceived lack of any unified regulatory framework to cover their activities. We consider the evolving attitudes amongst regulators, SWF officials, and independent analysts and commentators to the current and evolving regulatory environment for SWFs. Regulatory approaches inc

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Jůzl, Martin. "Výrobní hala LD Seating - stavebně technologický projekt." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-371963.

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The aim of the diploma thesis is a building-technological project on the production and assembly hall LD Seating in Boskovice u Brna. The solution is influenced by the existing hall in the area of the investor, where there will be a future new building. Based on this fact, the appropriate measures are chosen. The project puts emphasis on the off-road transport and the technological process of assembly of the prefabricated reinforced concrete hall, which will be solved from the financial and time point of view. The workflow will be affected by machine assembly, site facilities, and wider transp

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Cowan, Simon. "Topics in price cap regulation." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:388bf654-ee26-43eb-b6bd-58cff9d57084.

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This thesis examines the theoretical properties of different price cap schemes that have been applied in the UK and the USA. The objective is to assess the consequences for price structures and welfare of different ways of defining the regulated price index. Chapter 2 surveys the literature on regulation under asymmetric information that is related to price caps. Chapter 3 presents a general analysis of five main types of price cap when the regulated firm sets linear tariffs. The schemes are the Tariff Basket (TB) scheme, the Fixed Weights (F) scheme, the Average Revenue (AR) scheme, the Avera

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Maxwell, P. H. "Regulation of the erythropoietin gene." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:86a152eb-cfc8-4812-935e-c89ab48acee3.

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Erythropoietin (Epo) is a circulating hormone which regulates red blood cell production, and hence oxygen-carrying capacity. Three striking features of Epo gene expression are that it shows high level induction in response to hypoxia, that it is tightly tissue-restricted and that it is deficient in most forms of renal damage. Each of these aspects has been investigated in this thesis. Chapter 3 concerns the hypoxic-sensing system which induces Epo gene expression via an enhancer element in cultured hepatoma cells. Transient transfection was used to examine a range of cell-lines, which did not

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Fouracre, Jim P. "Genetic regulation of Kranz anatomy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7f10306d-d942-49cd-b12f-35b29311ad3c.

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The C₄ photosynthetic cycle acts to concentrate CO₂ around the enzyme Rubisco. By doing so, C₄ photosynthesis leads to increased radiation, water and nitrogen use efficiencies. As such, C₄ photosynthesis is the most productive form of photosynthesis known. Because it enables such high levels of productivity there are large international efforts to introduce C₄ photosynthesis into non-C₄ crop species such as rice. Kranz anatomy is a characteristic leaf cellular arrangement of concentric rings of bundle sheath and mesophyll cells around closely spaced veins and is crucial to C₄ photosynthesis in

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McCarthy, Michael Thomas. "Mechanisms of NKG2D ligand regulation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:69de3276-0b1e-4174-9309-988242468682.

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Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8<sup>+</sup> αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and cellular proliferation, settings also tightly associated with Warburg metabolism. The molecular events which determine NKG2D ligand expression status are unknown. Aims: We aim to enhance understanding of the deterministic molecular eve

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Greenacre, Jonathan. "The regulation of mobile money." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:6e559504-ac6f-47ac-8a32-c0030f963d3f.

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This thesis examines the regulation of 'mobile money'. This is an electronic payment and storage service provided by phone companies ('mobile money firms' or 'MM firms'). The first mobile money service, M-Pesa, was launched in Kenya in 2007. Since then, mobile money has spread rapidly throughout the developing world, particularly across Africa. A novel feature of mobile money is its ability to serve large numbers of people who do not have bank accounts, commonly labelled 'the unbanked'. The thesis offers a framework, based on a functional approach, to analyse the key regulatory and policy issu

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Friedrichsen, Hans. "Regulation of MITF and TFEB." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:7ee16ed1-3b71-4e6f-8ffb-19489153b28b.

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The bHLH-LZ transcription factors MITF and TFEB have been implicated in human disease, with their overexpression increasing the risk of developing cancer. The manner in which their access to E-box target motifs is controlled is an important consideration, as it is via binding to these motifs that bHLH-LZ factors mediate changes in gene expression. In addition to controlling the level of a given transcription factor, mounting evidence suggests that modulating MITF target specificity and TFEB access to the nucleus constitute an important means of regulating their functional output. Post-translat

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Wren-Lewis, Liam. "Regulation of utilities in developing countries." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:a64d775e-29f4-4c75-a6a3-d2c16098f2a1.

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The efficient operation and expansion of utilities in developing countries is crucial for growth and poverty reduction. However, recent reforms aimed at improving the performance of these sectors through privatization and the introduction of new regulatory regimes have had limited success. This thesis aims to consider the most pertinent problems for utility regulation in developing countries and how policy may need to be adapted appropriately. The thesis begins by surveying the most recent empirical and theoretical work on the area. I argue that four key institutional limitations commonly foun

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Baron, Alexander Macomber. "From teacher-regulation to self-regulation in early childhood : an analysis of Tools of the Mind's curricular effects." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:e58a6fcc-d737-44ae-a79c-67652d196099.

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The aim of my DPhil is to identify educational practices predictive of students' self-regulation development during early childhood. Specifically, I will analyze the Tools of the Mind preschool curriculum (Tools), which emphasizes students' self-regulation cultivation as its paramount aim. Since its development in 1993, Tools has spread to schools in the United States, Canada, and South America. In the face of Tools' proliferation, two questions emerge: does Tools significantly improve children's self-regulation skills? And, if so, then which of its effective elements could be applied across v

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Fletcher, Sally C. "Regulation of the base excision repair pathway." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:e3db2385-f9aa-4289-9547-3e37cbeddec9.

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Maintenance of genomic stability is paramount for survival of an organism; failure to repair DNA damage ultimately leads to the accumulation of genetically unstable cells and the onset of different human diseases including cancer. DNA single strand breaks and base oxidation/alkylation are among the most frequent types of DNA damage occurring spontaneously in cells. Base excision repair (BER), which copes with the majority of these lesions, is therefore a fundamental DNA repair system. Accordingly, it is important to understand how BER is regulated, and particularly, how and if BER is affected

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Sun, Bin. "Epigenetic regulation of postnatal subventricular zone development." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:e9ee95c1-b6cb-43c5-aef8-780e3fd50422.

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The postnatal/adult subventricular zone (SVZ) harbours neural stem cells (NSC), which produce neurons that migrate to the olfactory bulbs. SVZ NSC share several biological features with glia, especially reactive astrocytes. However, it is not clear how SVZ NSC simultaneously maintain self-renewal stem cell properties and the potential for generating daughter cells that differentiate into neurons. Multiple cyclin-dependent kinase inhibitors (CDKIs), including p16, p19 and p21 have been identified as indispensable for maintaining stem cell potential, in both cyclin dependent and independent mann

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Pliuskys, Laurynas. "Epigenetic regulation of the myeloid cell lineage." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f4ee6659-ce0b-4730-ae5b-95c141f82e10.

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The myeloid cell lineage is a fundamental element of the immune system and it can give rise to a diverse set of terminally differentiated cells, such as macrophages or osteoclasts among many others. Mutations or misregulation of gene expression may lead to severe clinical conditions, such as arthritis, osteoporosis or cancers. Epigenetics, the regulation of gene expression and chromatin remodelling, is implicated in cell differentiation, function and disease, and hence it is a promising new area to explore in order to explain underlying cellular mechanisms. Firstly, human macrophage subtypes w

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Chocian, Karolina. "Chromatin regulation of lifespan in C. elegans." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:ac80efde-7588-48e8-844c-26961e86bda4.

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The biological basis of lifespan regulation is a subject of intense interest, and epigenetic control of gene expression is thought to play an important role in the ageing process. A library of RNAi clones against chromatin factors was used to screen for their effects on lifespan in C.elegans, utilising microscopic examination of lipofuscin accumulation as a primary biomarker of ageing. A secondary RNAi screen involving full lifespan monitoring confirmed knock-downs of four genes, isw-1, cbp-1, mes-2 and jmjd-3.2, results in extension of lifespan. The use of mutant alleles of these genes also r

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Pepperell, Emma E. "The regulation of stem cell engraftment." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:873a14b9-6c7b-4643-bb34-4e1679d4f734.

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The engraftment of haemopoietic stem/progenitor cells (HSPCs) from umbilical cord blood (UCB) into adult recipients, although advantageous in terms of sourcing units, the decreased need to match donor and recipient and reduced risk of graft versus host disease (GvHD), is delayed compared to grafts using HSPCs from mobilised peripheral blood (MPB) or bone marrow (BM). One reason for this is the limited number of HSPCs (CD34+/CD133+ cells) in a unit of UCB compared to MPB or BM. The CXCR4-CXCL12 axis is widely recognised as a key player in the bone marrow homing, retention, and engraftment of HS

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Manolopoulos, Konstantinos. "Adrenergic regulation of regional fat metabolism." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:31dfdca3-e3df-41a6-bf27-74f6ccdcf0a7.

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Introduction: An increased gluteofemoral adipose tissue (AT) mass is associated with a protective cardiovascular and metabolic risk profile, and effective fatty acid retention in femoral AT has been proposed as a possible mechanism. Catecholamines are important regulators of AT lipolysis and blood flow (ATBF). The aim of the thesis was to investigate regional differences in the adrenergic regulation of fatty acid release and ATBF between abdominal and femoral AT in vivo. Furthermore, in vivo regional fatty acid trafficking was studied in a physiological setting over 24 h. Methods: Regional fat

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Richter, Wolf R. "'Better' regulation through social entrepreneurship? : innovative and market-based approaches to address the digital challenge to copyright regulation." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:8d609027-8605-4815-a499-3d2981028a24.

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After the initial excitement about the Internet as a space outside of governmental control has evaporated and courts in several states have applied national laws to ‘Cyberspace’, there is now a consensus among scholars that regulators have in principle the authority and capacity to regulate the Internet. Nevertheless, the application of the established tools of regulation - legislation and adjudication - to the current challenges to copyright regulation posed by the Internet has proven to be ineffective and produced undesirable side effects. Although market self-regulation has been suggested a

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Gandhi, Shaan-Chirag Chandrahas. "Regulation of stemness and differentiation in colorectal cancer." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:a32fd55a-4b1e-4a15-9f79-9fdbd986774a.

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The cancer stem cell (CSC) model of carcinogenesis and progression posits that within a tumor lies a subpopulation of cells that solely possess the ability to initiate a tumor and to differentiate into tumor cell lineages. Although the behavior of such cells is known, the challenge is to identify factors that characterize the CSC subpopulation. In this thesis, cell lines were identified that, when grown in three-dimensions, gave rise to organized colonies containing lumens originating from differentiating cells (“lumen lines”) and to densely-packed, spherical colonies originating from non-diff

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Loftus, Sarah Jane. "Regulation of E2F-1 by methylation and NEDDylation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e0befc5a-76a3-4a35-b768-80a9dda6f307.

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E2F-1 has a central role in cell cycle orchestration, and its activity is tightly regulated. One of the ways E2F-1 activity is controlled is by direct modification by post translational modifications such as acetylation, ubiquitination and phosphorylation. Here it was demonstrated that E2F-1 is targeted by two novel modifications, namely methylation by Set7/9 and NEDDylation, both within the DNA binding and heterodimerisation domain of the protein. NEDDylation and methylation of E2F-1 both decrease the stability and diminish the transcriptional activity of E2F-1. Lysine residues in E2F-1 invol

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Kuznetsova, Olga. "Regulation of human RNA polymerase II CTD modifications." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:e745b5b6-8a4a-4b7a-81d7-499bca8bfea1.

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Transcription of human protein-coding genes and most small nuclear RNA genes is mediated by RNA Polymerase II (Pol II). During a cycle of transcription, Pol II recruits a variety of factors that facilitate transcription elongation, RNA processing and termination, through its long, unstructured C-terminal domain (CTD). The CTD in humans comprises 52 tandem heptapeptide repeats with the consensus sequence Y<sub>1</sub>S<sub>2</sub>P<sub>3</sub>T<sub>4</sub>S<sub>5</sub>P<sub>6</sub>S<sub>7</sub>. Each amino acid of the heptapeptide can be chemically modified, which influences the recruitment of

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Zhao, Zhe. "Transcription regulation of Nrp1 during endothelial cell differentiation." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a76152dd-72f0-450c-aad2-d0db732f2e6d.

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Various diseases, including cancer, stroke and heart attack, are associated with disruption of the vascular system. However, lack of a profound understanding of the transcription regulation during vascular development hinders the formation of effective molecular intervention strategies targeting angiogenesis. Here we describe an enhancer of Neuropilin1 (Nrp1) from the second intron of the gene that directs arterial and coronary endothelial cell-specific expression. Mice transgenic for either human or mouse sequences of the Nrp1in2 enhancers drove expression of the LacZ reporter gene specifical

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Lagiotis, Georgios. "MicroRNA regulation of axial patterning during Arabidopsis embryogenesis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e2abd8c6-924b-4085-bd18-ecd6cebc05de.

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Pattern formation is the process by which undifferentiated cells divide and differentiate to generate complex tissues and organs. In plants, pattern formation begins in embryogenesis and continues post-embryonically with the function of the meristems. microRNAs (miRNAs), which are small regulatory RNAs that repress gene expression, are involved in a variety of patterning processes in plants, including the formation and function of the meristems and establishment of polarity. For example, regulation of the class III HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP III) transcription factors by miR165/6 is no

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Abraham, Aswin George. "Nucleophosmin and p14ARF mediated regulation of p53." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:06e101f9-f0e3-42b9-ada9-7a1b1a1f4a87.

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Tumour initiation and progression occur due to oncogenic mutations that also contribute to therapeutic resistance in many human tumours. Mutations activating the "PI3K/AKT" signalling pathway and inactivating the "TP53" tumour suppressor gene are common mechanisms that cancer cells require to proliferate and escape pre-programmed cell death. p53 mutant (p53mut) tumours not only fail to respond to DNA damaging therapy, but are also described to promote therapeutic resistance by dominant negative suppression of p53 dependent promoter activity. Our work identifies the crucial interaction between

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Hole, Alison Jennifer. "The regulation and inhibition of P-TEFb." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:18ba1399-e3db-4ed6-bd9b-019bbd3c0b65.

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Correct regulation of transcription is essential for maintaining a healthy cellular state. During transcription RNA polymerase II (Pol II) proceeds in a regulated manner through several transitions to ensure appropriate control of synthesis and enable correct processing of the pre-RNA. Shortly after initiation Pol II is caused to pause by the binding of factors, DSIF and NELF. To enable transition of Pol II into the elongation phase CDK9/cyclin T phosphorylates the C-terminal domain (CTD) of Pol II, DSIF and NELF. This phosphorylation releases the paused state and provides an alternative set o

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Kotak, Akshay. "Essays on financial intermediation, stability, and regulation." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:112b32a7-fa60-4baa-a325-15e014798cea.

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Modern banking theories provide a host of explanations for the existence of intermediaries, highlight their important influence on economic growth, delineate the risks inherent in the services they provide, and illustrate the market failures and real costs of bank failures that precipitate the need for regulation and oversight of the sector. This thesis is a collection of three essays that looks at three of these key aspects of financial intermediaries - the development of financial intermediaries, the function of the lender of last resort that has emerged as an important part of the safety ne

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Schmidt, Johannes Reiner Mathias. "Role and regulation of TBX2 and TBX3." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:5e491c96-ba71-4504-837d-561bab25622e.

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The T-box family of transcription factors plays a crucial role during embryonic development, especially in heart and limb formation. In the adult organism, two members of the family, TBX2 and TBX3, have been found to be overexpressed in several types of cancer associating them with tumour biology. However, little is known about their regulatory targets and subsequent function aside from their well-described role during development, that would give indications of their overall contribution to tumourigenesis. Here, an agnostic, genome-wide approach is chosen to reveal novel TBX2 and TBX3 regulat

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Ghari, Seyed Fatemeh Fatemeh. "Regulation of E2F1 by PAD4 mediated citrullination." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:7ad98e9b-ba63-497a-996b-775494322d21.

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Peptidyl arginine deiminase (PAD) 4 is a nuclear enzyme that converts arginine residues to citrulline. PAD4 activity has been implicated in inflammatory disease and cancer, although its mechanism of action, particularly the identity of functionally relevant targets, remains unclear. Moreover, there are no known reader domains specifically recognising citrulline modifications. E2F transcription factors play a central role in regulating gene expression during cellular proliferation but in addition participate in diverse biological processes. Furthermore, it is known that arginine methylation pro

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Agkatsev, Sarina. "Regulation of MITF and Brn2 in melanoma." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:58354c05-55b7-46ef-8903-df3703fd04be.

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Melanoma is the most aggressive skin cancer with high recurrence and low survival rate. In addition to genetic mechanisms, resistance also arises from phenotypic heterogeneity in which a proportion of cells, the so-called melanoma stem or initiating cells, survive therapy. Due to a lack of reliable markers, however, there is still debate about the existence of these cells in melanoma. Consistent with phenotypic heterogeneity, previous observations in our laboratory have demonstrated that cells in melanoma can reversibly segregate in vivo into different subpopulations with different properties,

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Mangat, Davinderpreet Singh. "The regulation of Mps1 kinase during mitosis." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:80ced82c-6424-45a4-bdda-f83c270d3eeb.

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The spindle assembly checkpoint (SAC), a conserved surveillance system, ensures genomic stability by delaying anaphase entry until all sister chromatids are attached to the mitotic spindle. The SAC network is active at unattached kinetochores and a complex signalling cascade culminates in the production of a diffusible 'wait anaphase' signal. Regulation of protein:protein interactions by reversible phosphorylation is critical in this signalling pathway. The checkpoint kinase Mps1, a central regulator of the SAC, plays a positive role in enabling protein interactions. Mps1 builds the SAC networ

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Chessin, Mati C. "An Experimental Investigation on the Effects of Buffering Regulation on Time-Critical Delivery of Objects on a Multi-Conveyor System." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14493.

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This thesis experimentally investigates the effects of buffer regulation on the delivery of randomly spaced objects through a multi-conveyor system according to a demanded throughput and spacing. A regulator is developed and tested in conjunction with on ongoing research project at Georgia Tech investigating the automated transfer of live birds. In this thesis, an algorithm is proposed to identify and compensate for the spacing deviations of objects entering a system comprised of three serially connected conveyors. The regulator acts to delay the time each object spends on the middle conveyo

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Stoll-Davey, Camille. "Global comparison of hedge fund regulations." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:d08de3ea-6818-46cf-96b1-1bbb785a7504.

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The regulation of hedge funds has been at the centre of a global policy debate for much of the past decade. Several factors feature in this debate including the magnitude of current global investments in hedge funds and the potential of hedge funds to both generate wealth and destabilise financial markets. The first part of the thesis describes the nature of hedge funds and locates the work in relation to four elements in existing theory including regulatory competition theory, the concept of differential mobility as identified by Musgrave, Kane’s concept of the regulatory dialectic between re

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Burokas, Mantas. "Branduolinės energetikos objektų statybos teisinio reguliavimo ypatumai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20090122_144141-79907.

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Branduolinės energetikos objektas – statybos teisinis reguliavimas – branduolinės saugos principai – specialusis teisinis reguliavimas Branduolinės energetikos objektų statybos teisinis reguliavimas yra unikalus, išsiskiriantis iš kitų statinių statybos padidintu dėmesiu branduolinės saugos priemonių įgyvendinimui. Šio objekto statybos teisinio reguliavimo srities svarba tampa vis aktualesne dabartinių branduolinės energetikos objektų statybos procesų aktyvėjimo kontekste. Nežiūrint į tai, jog Lietuva priklauso branduolinę energetiką vystančių šalių grupei, siekiančiai plėsti branduolinės ener

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Stewart, Melanie Ann. "Fatty acids and the regulation of pyruvate dehydrogenase interconversion." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:d05910c0-f7a1-4363-ac2c-a9a1eb857964.

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This thesis presents evidence for a novel mechanism of regulation of pyruvate dehydrogenase (PDH) kinase by fatty acids and also results of a study of muscle triacylglycerol concentration. In animals regulation of PDH complex activity is central to the selection of respiratory fuels and to the conservation of glucose during carbohydrate deprivation. The principal means of regulation of PDH complex is interconversion of phosphorylated (inactive) and dephosphorylated (active) forms effected by PDH kinase and PDH phosphatase. Earlier in vitro studies by others had identified both shorter term (mi

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Mattick, Paul A. D. "Regulation of potassium currents in the sino-atrial node." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:d1af4bea-110f-4bc1-a691-a899928bd95e.

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Serra, Barros Ana Cristina. "Transcriptional regulation by non-coding RNAs in Saccharomyces cerevisiae." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e523d0ee-bb3a-4217-aeba-9e6e398fc86a.

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Genome-wide studies in Saccharomyces cerevisiae have revealed that the majority of the genome is transcribed on both strands, producing both coding and non-coding RNAs (ncRNAs). Initially, these ncRNAs were regarded as spurious transcripts but some have since been shown to have important roles as transcriptional regulators. Very little is understood about how ncRNAs are initiated, terminated and processed or how this influences their function. To address these questions, the expression, stability, and subcellular localization of the ncRNAs at the endogenous GAL locus was analysed. This reveale

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Douglas, Sophie Georgina. "Regulation of CRAC channels and agonist-induced Ca2+ signals." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ae94ca14-ac95-4ea6-b14a-14f9f7bafd63.

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Calcium ions (Ca2+) are extremely important intracellular messengers, activating a plethora of cellular processes. Growing evidence now points to a major role for the local Ca2+ signal in driving specific cellular responses. The simplest and most fundamental local Ca2+ signal is the Ca2+ microdomain, which rapidly forms when Ca2+ permeable ion channels open. In non-excitable cells the dominant Ca2+ entry channels are store-operated Ca2+ channels (SOCCs). The best characterised is the Ca2+ release activated Ca2+ (CRAC) channel. How local Ca2+ entry through CRAC channels impacts on channel funct

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Harrison, Oliver J. "The role of IL-18 in intestinal immune regulation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:adcd849b-6a08-4ba9-b7db-0743a29cb377.

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Elevated levels of the cytokine interleukin-18 (IL-18) are found in many chronic inflammatory disorders, including inflammatory bowel disease (IBD). However, the role of IL-18 in mucosal immunity and inflammation is not well understood. At mucosal and environmental interfaces, Th17 cells have been shown to contribute to protection from pathogenic infection. In contrast, regulatory T (Treg) cells maintain intestinal homeostasis by preventing aberrant inflammatory responses to the resident microbiota. We demonstrate that under homeostatic conditions, colonic Th17 cells highly express IL-18 recep

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Hughes, Thomas. "The genetic regulation of Kranz anatomy in maize." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:86184e64-c7bb-43e9-9320-0ebbb2793ea8.

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The C<sub>4</sub> photosynthetic pathway acts to concentrate CO<sub>2</sub> around the enzyme Ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco), ensuring that it catalyses a carboxylation rather than oxygenation reaction, which in turn suppresses photorespiration. In nearly all cases C<sub>4</sub> photosynthesis is underpinned by characteristic Kranz anatomy, with concentric wreaths of bundle sheath (BS) and mesophyll (M) cells surrounding closely spaced veins. The increased yields associated with the C<sub>4</sub> pathway have lead to the suggestion that C<sub>3</sub> crops such as ri

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Akkaya, Erdem. "Regulation Of the human RNA nucleotidyl transferase ZCCHC11." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3a7f6958-cb91-493e-a1c3-2c22b6665f62.

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Terminal uridylation of RNA 3ꞌ ends has recently been recognised as an important biological regulatory mechanism. The human terminal uridyl transferase ZCCHC11 was shown previously to uridylate and thereby regulate replication-dependent histone mRNAs and several miRNA precursors and mature miRNAs. Studies in cancer cell lines, mouse models and patient samples suggest that ZCCHC11 is a potential oncogene. However, very little is known about regulation of its expression and subcellular localisation. In this study, the regulation of the expression of ZCCHC11 was investigated, especially in relati

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Vergari, Elisa. "Regulation of somatostatin secretion from pancreatic δ-cells". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:52565b17-e2c3-445e-890e-c76ca805e908.

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The somatostatin-secreting δ-cell is the least abundant cell type in the pancreatic islet and this may explain why very little is known about its role and function. In this thesis, I have characterized the SST-Cre-GCaMP3 mouse model in which the genetically encoded Ca<sup>2+</sup> sensor GCaMP3 is expressed in somatostatin-expressing cells. Using these mice, glucose-induced somatostatin secretion was found to be inhibited by a KATP channel-dependent membrane depolarization and amplified by Ca<sup>2+</sup> -induced Ca<sup>2+</sup> release (CICR) mediated by activation of ryanodine recepto

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