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Journal articles on the topic 'Olfactory mucosa'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Miller, M. A., S. J. Kottler, J. A. Ramos-Vara, P. J. Johnson, V. K. Ganjam, and T. J. Evans. "3-Methylindole Induces Transient Olfactory Mucosal Injury in Ponies." Veterinary Pathology 40, no. 4 (2003): 363–70. http://dx.doi.org/10.1354/vp.40-4-363.

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Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies, but olfactory mucosal injury has not been reported. To evaluate the effect of 3MI on equine olfactory mucosa, ponies were dosed orally with 100 mg 3MI/kg ( n = 9) or corn oil vehicle ( n = 6). All ponies treated with 3MI developed obliterative bronchiolitis with mild olfactory injury. By 3 days after 3MI dosing, olfactor

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2

Jiang, Rong-San, and Yu-Yu Lu. "Functional Olfactory Nerve Regeneration Demonstrated by Thallium-201 Olfacto-Scintigraphy in Patients with Traumatic Anosmia: A Case Report." Case Reports in Otolaryngology 2019 (November 16, 2019): 1–7. http://dx.doi.org/10.1155/2019/1069741.

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Head trauma is one of the most common etiologies of olfactory dysfunction. It is difficult to use either the olfactory function test or magnetic resonance imaging to directly assess the course of damage to olfactory nerves. Thallium-201 (201Tl) olfacto-scintigraphy has been shown to be an able means for objectively assessing the olfactory nerve transport function. It is expected to be used to evaluate olfactory nerve regeneration after damage to the olfactory nerves. However, no such result has been reported. We present a patient who lost his olfactory function after experiencing head trauma.

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3

Schwob, James E., Donald A. Leopold, Karen E. Mieleszko Szumowski, and Precha Emko. "Histopathology of Olfactory Mucosa in Kallmann's Syndrome." Annals of Otology, Rhinology & Laryngology 102, no. 2 (1993): 117–22. http://dx.doi.org/10.1177/000348949310200208.

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Olfactory mucosa was harvested by intranasal biopsy from a man with Kallmann's syndrome in whom the absence of the olfactory bulbs was documented by magnetic resonance imaging. On electron microscopic examination, several pathologic changes were evident in the olfactory mucosa. First, most olfactory neurons lacked cilia (ie, were morphologically immature). Second, the fila olfactoria had fewer than the normal number of axons, and a large proportion of them were apparently undergoing electron lucent degeneration. Finally, neuromatous collections of axons were seen superficial to the basement me

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4

Lampinen, Riikka, Veronika Górová, Simone Avesani, et al. "Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients." International Journal of Molecular Sciences 23, no. 8 (2022): 4123. http://dx.doi.org/10.3390/ijms23084123.

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Olfactory function, orchestrated by the cells of the olfactory mucosa at the rooftop of the nasal cavity, is disturbed early in the pathogenesis of Alzheimer’s disease (AD). Biometals including zinc and calcium are known to be important for sense of smell and to be altered in the brains of AD patients. Little is known about elemental homeostasis in the AD patient olfactory mucosa. Here we aimed to assess whether the disease-related alterations to biometal homeostasis observed in the brain are also reflected in the olfactory mucosa. We applied RNA sequencing to discover gene expression changes

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5

Yamagishi, Masuo, and Yuichi Nakano. "Immunohistochemical Studies of Olfactory Mucosa in Patients with Olfactory Disturbances." American Journal of Rhinology 3, no. 4 (1989): 205–10. http://dx.doi.org/10.2500/105065889782009615.

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In order to examine the functional morphology of the human olfactory mucosa when olfaction is disturbed, immunohistochemical methods have been applied to mucosal biopsies. In the group of patients examined anosmia was due to bilateral choanal atresia, to chronic sinusitis, to the common cold (viral infection), and to head trauma. One subject had anosmia of unknown etiology. Antibodies against neuron-specific enolase, glia-specific S-100 protein, and cytokeratin were used as markers for the functional morphology of olfactory receptor cells, Bowman's glands, nerve bundles, and basal cells. Each

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Lampinen, Riikka, Mohammad Feroze Fazaludeen, Simone Avesani, et al. "Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients." Cells 11, no. 4 (2022): 676. http://dx.doi.org/10.3390/cells11040676.

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Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early in several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to the olfactory mucosal cells remain poorly described. The aim of this study was to evaluate the olfactory mucosa differences between cognitively healthy individuals and Alzheimer’s disease patients. We report increased amyloid-beta secretion in Alzheimer’s disease olfactory mucosal cells and detail cell-type-specific gene expression patterns, unveiling 240 differ

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7

Yamagishi, Masuo, Yoichi Ishizuka, and Kohji Seki. "Pathology of Olfactory Mucosa in Patients with Alzheimer's Disease." Annals of Otology, Rhinology & Laryngology 103, no. 6 (1994): 421–27. http://dx.doi.org/10.1177/000348949410300601.

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Characteristic changes that appear in the biopsied olfactory mucosa of patients with Alzheimer's disease (AD) were examined with immunohistochemical staining. Specimens were obtained from patients with clinical diagnoses of AD. Patients with vascular dementia and age-matched patients without dementia were used for controls. In most AD cases, neurofibrillary tangle-like abnormal tau protein (Tau) immunoreactivity was seen in the dendrites and perikarya of the olfactory receptor cells and in the nerve bundles. A senile plaquelike extracellular mass was found in the olfactory epithelium, and it r

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8

Jacobs, Sophie, Caroline Zeippen, Fanny Wavreil, Laurent Gillet та Thomas Michiels. "IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa". Viruses 11, № 8 (2019): 757. http://dx.doi.org/10.3390/v11080757.

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Murid herpesvirus-4 (MuHV-4), a natural gammaherpesvirus of rodents, can infect the mouse through the nasal mucosa, where it targets sustentacular cells and olfactory neurons in the olfactory epithelium before it propagates to myeloid cells and then to B cells in lymphoid tissues. After establishment of latency in B cells, viral reactivation occurs in the genital tract in 80% of female mice, which can lead to spontaneous sexual transmission to co-housed males. Interferon-lambda (IFN-λ) is a key player of the innate immune response at mucosal surfaces and is believed to limit the transmission o

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9

Yamagishi, Masuo, Hideo Nakamura, Satoshi Hasegawa, Shoji Suzuki, and Yuichi Nakano. "Immunohistochemical Examination of Olfactory Mucosa in Patients with Olfactory Disturbance." Annals of Otology, Rhinology & Laryngology 99, no. 3 (1990): 205–10. http://dx.doi.org/10.1177/000348949009900309.

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The olfactory mucosa was examined by immunohistochemistry in patients with olfactory disturbance: anosmia due to choanal atresia and chronic sinusitis, early-stage common cold, late-stage common cold, and head trauma. The results indicate that the olfactory mucosa of patients with olfactory disturbance shows specific kinds of immunoreactive patterns and that immunohistochemistry is useful for examining the degree of degeneration of pathologic human olfactory mucosa and for clarification of prognosis.

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10

Moseman, E. Ashley. "Mucosal immune mediated protection of the CNS following olfactory viral infection." Journal of Immunology 202, no. 1_Supplement (2019): 66.7. http://dx.doi.org/10.4049/jimmunol.202.supp.66.7.

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Abstract Barrier immunity, particularly at mucosal surfaces, provides a first line of defense against invading pathogens. Unlike classical mucosal barrier surfaces in the gut and respiratory tract, the olfactory epithelium within the nose is a specialized barrier structure containing layers of olfactory sensory neurons (OSNs) dedicated to our sense of smell. Within nasal airways, OSNs are vulnerable to infection but also directly connected to the brain, thus anatomically, the olfactory epithelium functions as a mucosal barrier to the central nervous system (CNS). Upper respiratory viral infect

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11

McDonald, Cameron, Alan Mackay-Sim, Denis Crane, and Wayne Murrell. "Could Cells from Your Nose Fix Your Heart? Transplantation of Olfactory Stem Cells in a Rat Model of Cardiac Infarction." Scientific World JOURNAL 10 (2010): 422–33. http://dx.doi.org/10.1100/tsw.2010.40.

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This study examines the hypothesis that multipotent olfactory mucosal stem cells could provide a basis for the development of autologous cell transplant therapy for the treatment of heart attack. In humans, these cells are easily obtained by simple biopsy. Neural stem cells from the olfactory mucosa are multipotent, with the capacity to differentiate into developmental fates other than neurons and glia, with evidence of cardiomyocyte differentiationin vitroand after transplantation into the chick embryo. Olfactory stem cells were grown from rat olfactory mucosa. These cells are propagated as n

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12

Sato, Masanori, Namio Kodama, Tatsuya Sasaki, and Mamoru Ohta. "Olfactory evoked potentials: experimental and clinical studies." Journal of Neurosurgery 85, no. 6 (1996): 1122–26. http://dx.doi.org/10.3171/jns.1996.85.6.1122.

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✓ Olfactory evoked potentials (OEPs), obtained by electrical stimulation of the olfactory mucosa, were recorded in dogs and humans to develop an objective method for evaluating olfactory functions. In dogs, OEPs were recorded from the olfactory tract and the scalp. The latency of the first negative peak was approximately 40 msec. A response was not obtained after stimulation of the nasal mucosa and disappeared after sectioning of the olfactory nerve. With increasing frequencies of repetitive stimulation, the amplitude was reduced, suggesting that the response was synaptically mediated. These r

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13

Escada, Pedro Alberto, Carlos Lima, and José Madeira da Silva. "The human olfactory mucosa." European Archives of Oto-Rhino-Laryngology 266, no. 11 (2009): 1675–80. http://dx.doi.org/10.1007/s00405-009-1073-x.

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14

Smutzer, Gregory, Virginia M. Y. Lee, John Q. Trojanowski, and Steven E. Arnold. "Human Olfactory Mucosa in Schizophrenia." Annals of Otology, Rhinology & Laryngology 107, no. 4 (1998): 349–55. http://dx.doi.org/10.1177/000348949810700415.

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Recent evidence indicates that developmental anomalies may underlie some symptoms of schizophrenia, while psychophysical studies have demonstrated olfactory deficits in this disease. The postmortem olfactory mucosa of elderly schizophrenic patients was examined to characterize the molecular phenotype of this tissue. The distribution of developmentally regulated cytoskeletal proteins, a synaptic vesicle protein, a neural marker protein, a receptor for trophic molecules, axonal guidance and cell migration proteins, and neuronal and glial cytoskeletal proteins of various degrees of phosphorylatio

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15

Marioni, G., G. Ottaviano, A. Staffieri, et al. "Nasal functional modifications after physical exercise: olfactory threshold and peak nasal inspiratory flow." Rhinology journal 48, no. 3 (2010): 277–80. http://dx.doi.org/10.4193/rhino09.141.

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Statement of problem: The respiratory nasal effects of physical exercise have been extensively investigated; on the other hand there are no data regarding olfactory threshold modification after aerobic physical exercise. Methods: The present prospective study investigated the modifications in nasal respiratory flows and olfactory thresholds after controlled aerobic physical exercise in a cohort of 15 adult, healthy volunteers. The Peak Nasal Inspiratory Flow (PNIF), and the Sniffin’ Sticks olfactory threshold test were used for our determinations. Main results: The mean PNIF after physical exe

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16

Ogino-Nishimura, Eriko, Takayuki Nakagawa, Yoshiki Mikami, and Juichi Ito. "Olfactory Ensheathing Cell Tumor Arising from the Olfactory Mucosa." Case Reports in Medicine 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/426853.

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We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative sta

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17

Krishna, N. S. Rama, Thomas V. Getchell, Yogesh C. Awasthi, Nimrat Dhooper, and Marilyn L. Getchell. "Age- and Gender-Related Trends in the Expression of Glutathione S-Transferases in Human Nasal Mucosa." Annals of Otology, Rhinology & Laryngology 104, no. 10 (1995): 812–22. http://dx.doi.org/10.1177/000348949510401012.

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The cellular expression of α, μ, and π classes of glutathione S-transferases (GSTs) was investigated in human nasal mucosa by means of immunocytochemical techniques. In the olfactory mucosa, immunoreactivity for GST-α was most intense in the acinar cells of the Bowman's glands, with weak immunoreactivity in the supranuclear region of sustentacular cells. Whereas GST-π was localized only in the sustentacular cells, no GST-μ was detected. In the respiratory mucosa, GST-α and GST-π were detected at the brush borders of ciliated columnar epithelial cells. There were age- and gender-related trends

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18

Muluk, Nuray Bayar. "Olfactory functions in Behçet’s disease: A review." Romanian Journal of Rhinology 8, no. 32 (2018): 213–17. http://dx.doi.org/10.2478/rjr-2018-0023.

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Abstract OBJECTIVES. We reviewed the relationship between olfactory functions and Behçet’s disease (BD). MATERIAL AND METHODS. We searched Pubmed, Google, Google Scholar and Proquest Cebtral Database with the key words of “olfactory”, “functions”, “smell”, “nasal” and “Behçet’s disease”. RESULTS. Behçet’s disease influences the nasal mucosa. Nasal mucosal inclusion causes mucosal ulcers, pain, burning, nasal obstruction, epistaxis, nasal itching and dysosmia. Nasal cartilage deformity is also reported. The higher rate of comorbid chronic rhinosinusitis (CRS) in BD patients may likewise be beca

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19

Fong, Karen, Robert C. Kern, James Foster, and Dimitri Pitovski. "Corticosteroids and the Olfactory Mucosa." Otolaryngology–Head and Neck Surgery 113, no. 2 (1995): P138. http://dx.doi.org/10.1016/s0194-5998(05)80812-5.

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20

Holbrook, Eric H., Lina Rebeiz, and James E. Schwob. "Office-based olfactory mucosa biopsies." International Forum of Allergy & Rhinology 6, no. 6 (2016): 646–53. http://dx.doi.org/10.1002/alr.21711.

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21

Minkelyte, Kamile, Andrew Collins, Modinat Liadi, Ahmed Ibrahim, Daqing Li, and Ying Li. "High-Yield Mucosal Olfactory Ensheathing Cells Restore Loss of Function in Rat Dorsal Root Injury." Cells 10, no. 5 (2021): 1186. http://dx.doi.org/10.3390/cells10051186.

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In a previous study, we reported that no axons were crossing from the severed dorsal roots to the spinal cord using the rat dorsal rhizotomy paradigm. The injury caused ipsilateral deficits of forepaw function. An attempt to restore the function by transplanting cells containing 5% olfactory ensheathing cells (OECs) cultured from the olfactory mucosa did not succeed. However, obtaining OECs from the olfactory mucosa has an advantage for clinical application. In the present study, we used the same rhizotomy paradigm, but rats with an injury received cells from a modified mucosal culture contain

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22

Inamitsu, Mayumi, Tadashi Nakashima, and Takuya Uemura. "Immunopathology of olfactory mucosa following injury to the olfactory bulb." Journal of Laryngology & Otology 104, no. 12 (1990): 959–64. http://dx.doi.org/10.1017/s0022215100114483.

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AbstractRemoval of the olfactory bulb was performed on rats in an attempt to elucidate the processes of olfactory dysfunction following head injury. Degeneration and regeneration of the olfactory mucosa were examined, histopathologically and immunohistochemically. We used antisera to olfactory marker protein (OMP) and neuron specific enolase (NSE) as a marker of the mature olfactory receptor neurons. Following rapid degeneration after bulbectomy, the olfactory receptor neurons regenerated. OMP and NSE containing cells re-appeared 49 days later. However, the cell population of the neuroepitheli

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23

Mollichella, Marie-Laure, Violaine Mechin, Dany Royer, Patrick Pageat, and Pietro Asproni. "Isolation and Characterization of Cat Olfactory Ecto-Mesenchymal Stem Cells." Animals 12, no. 10 (2022): 1284. http://dx.doi.org/10.3390/ani12101284.

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The olfactory mucosa contains olfactory ecto-mesenchymal stem cells (OE-MSCs) which show stemness features, multipotency capabilities, and have a therapeutic potential. The OE-MSCs have already been collected and isolated from various mammals. The aim of this study was to evaluate the feasibility of collecting, purifying and amplifying OE-MSCs from the cat nasal cavity. Four cats were included in the study. Biopsies of olfactory mucosa were performed on anesthetized animals. Then, the olfactory OE-MSCs were isolated, and their stemness features as well as their mesodermal differentiation capab

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Feng, Wen-Hui, John S. Kauer, Lester Adelman, and Barbara R. Talamo. "New structure, the ?olfactory pit,? in human olfactory mucosa." Journal of Comparative Neurology 378, no. 4 (1997): 443–53. http://dx.doi.org/10.1002/(sici)1096-9861(19970224)378:4<443::aid-cne1>3.0.co;2-2.

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Rambotti, M. G., C. Saccardi, A. Spreca, M. C. Aisa, I. Giambanco, and R. Donato. "Immunocytochemical localization of S-100 beta beta protein in olfactory and supporting cells of lamb olfactory epithelium." Journal of Histochemistry & Cytochemistry 37, no. 12 (1989): 1825–33. http://dx.doi.org/10.1177/37.12.2685111.

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By immunocytochemistry, we have identified two novel cell types, olfactory and supporting cells of lamb olfactory epithelium, expressing S-100 beta beta protein. S-100 immune reaction product was observed on ciliary and plasma membranes, on axonemes and in the cytoplasm adjacent to plasma membranes and to basal bodies of olfactory vesicles. A brief treatment of olfactory mucosae with Triton X-100 before fixation is necessary for detection of S-100 beta beta protein within olfactory vesicles. In the absence of such a treatment, the immune reaction product is restricted to ciliary and plasma mem

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Yamagishi, Masuo, Ryusuke Okazoe, and Yoichi Ishizuka. "Olfactory Mucosa of Patients with Olfactory Disturbance following Head Trauma." Annals of Otology, Rhinology & Laryngology 103, no. 4 (1994): 279–84. http://dx.doi.org/10.1177/000348949410300404.

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The olfactory mucosa in 7 patients with olfactory disturbance following head trauma were sampled for biopsy with special biopsy forceps and examined by immunohistochemical staining with anti—neuron-specific enolase (NSE) and S-100 protein (S-100) antibodies. The residual olfactory receptor cells and nerve bundles were counted, and the degree of degeneration was determined. In 5 patients, olfactory receptor cells that reacted with anti-NSE antiserum remained, although the number varied with the patient, and in 2 patients the receptor cells disappeared. In the lamina propria, the S-100–immunorea

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Schulze, Gene E., Jim E. Proctor, Mark A. Dominick, et al. "Intranasal Toxicity of BMS-181885, A Novel 5-HT1 Agonist." International Journal of Toxicology 18, no. 5 (1999): 285–96. http://dx.doi.org/10.1080/109158199225206.

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One-month intranasal toxicity studies were conducted with BMS-181885 at doses of 1.5, 9, or 15 mg/animal/day in rats and 4, 24, or 40 mg/animal/day in monkeys. A 1-month intermittent intranasal toxicity study was also conducted in monkeys at doses of 3, 6, and 12 mg/animal 3 days per week. BMS-181885 was generally well tolerated in rats but resulted in dose-dependent nasal mucosal injury, primarily characterized by subacute inflammation of the nasal mucosa, and degeneration, single-cell necrosis, and/or erosion of the olfactory epithelium and, to a lesser extent, the respiratory epithelium. In

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Getchell, Marilyn L., Ying Chen, Xinxin Ding, D. Larry Sparks, and Thomas V. Getchell. "Immunohistochemical Localization of a Cytochrome P-450 Isozyme in Human Nasal Mucosa: Age-Related Trends." Annals of Otology, Rhinology & Laryngology 102, no. 5 (1993): 368–74. http://dx.doi.org/10.1177/000348949310200509.

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Immunoperoxidase staining with an antibody to cytochrome P-450 (NMa) was used to investigate the localization of this isozyme in the human nasal mucosa. Olfactory mucosa was identified by staining of olfactory receptor cells with an antibody to olfactory marker protein. Immunoreactivity to NMa was localized in sustentacular cells in the olfactory epithelium, and in Bowman's gland acinar cells and vascular endothelial cells in the lamina propria. In the respiratory mucosa, ciliated epithelial cells, as well as serous gland acinar cells and vascular endothelial cells in the lamina propria, were

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Ottaviano, G., A. Staffieri, P. Stritoni, et al. "Nasal dysfunction induced by chlorinate water in competitive swimmers." Rhinology journal 50, no. 3 (2012): 294–98. http://dx.doi.org/10.4193/rhino11.024.

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Aims: Swimmers commonly complain of nasal symptoms probably due to mucosal irritation caused by chlorinated water. The aim of the present prospective study was to investigate changes in nasal function and cytology in a cohort of 15 volunteer competitive swimmers, as compared with a control group of 15 competitive athletes practicing other sports. Methods: Olfactory threshold for n-butanol was measured in a population of competitive swimmers. Changes in nasal function and cytology were compared between the two groups of volunteer competitive athletes. Results: There were no significant differen

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Genter, Mary Beth, Dawn M. Burman, Soundarapandian Vijayakumar, Cathy L. Ebert, and Bruce J. Aronow. "Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa." Physiological Genomics 12, no. 1 (2002): 35–45. http://dx.doi.org/10.1152/physiolgenomics.00120.2002.

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Alachlor induces olfactory mucosal tumors in rats in a highly ordered temporal process. We used GeneChip analysis to test the hypothesis that histological progression and oncogenic transformation are accompanied by gene expression changes that might yield clues as to the molecular pathogenesis of tumor formation. Acute alachlor exposure caused upregulation of matrix metalloproteinases (MMP)-2 and -9, tissue inhibitor of metalloproteinase-1, carboxypeptidase Z, and other genes related to extracellular matrix homeostasis. Heme oxygenase was upregulated acutely and maintained elevated expression.

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Covington, J. A., J. W. Gardner, A. Hamilton, T. C. Pearce, and S. L. Tan. "Towards a truly biomimetic olfactory microsystem: an artificial olfactory mucosa." IET Nanobiotechnology 1, no. 2 (2007): 15. http://dx.doi.org/10.1049/iet-nbt:20060015.

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KASHIWAYANAGI, MAKOTO, KIMIE SAI, and KENZO KURIHARA. "Cell Suspension from Porcine Olfactory Mucosa." Annals of the New York Academy of Sciences 510, no. 1 Olfaction and (1987): 398–99. http://dx.doi.org/10.1111/j.1749-6632.1987.tb43569.x.

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Hornung, David E., Steven L. Youngentob, and Maxwell M. Mozell. "Olfactory mucosa/air partitioning of odorants." Brain Research 413, no. 1 (1987): 147–54. http://dx.doi.org/10.1016/0006-8993(87)90163-6.

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Sakai, Masao, Makoto Ashihara, Tadao Nishimura, and Ikuko Nagatsu. "Carnosine immunohistochemistry in human olfactory mucosa." Neuroscience Research Supplements 15 (January 1990): S97. http://dx.doi.org/10.1016/0921-8696(90)90321-s.

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Sakai, Masao, Makoto Ashihara, Tadao Nishimura, and Ikuko Nagatsu. "Carnosine immunohistochemistry in human olfactory mucosa." Neuroscience Research Supplements 11 (January 1990): S97. http://dx.doi.org/10.1016/0921-8696(90)90744-n.

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Miani, Cesare, Fulvia Ortolani, Anna Maria Bergamin Bracale, Lucia Petrelli, Alberto Staffieri, and Maurizio Marchini. "Olfactory mucosa histological findings in laryngectomees." European Archives of Oto-Rhino-Laryngology 260, no. 10 (2003): 529–35. http://dx.doi.org/10.1007/s00405-003-0638-3.

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Ansari, Khurshed A. "Olfactory mucosa, aluminosilicates and Alzheimer's disease." Neurobiology of Aging 7, no. 6 (1986): 575–76. http://dx.doi.org/10.1016/0197-4580(86)90126-0.

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Olson, M. J., J. L. Martin, A. C. LaRosa, A. N. Brady, and L. R. Pohl. "Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats." Journal of Histochemistry & Cytochemistry 41, no. 2 (1993): 307–11. http://dx.doi.org/10.1177/41.2.8419465.

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The enzymatic esterase activity of carboxylesterases is integral to the nasal toxicity of many esters used as industrial solvents or in polymer manufacture, including propylene glycol monomethyl ether acetate, dimethyl glutarate, dimethyl succinate, dimethyl adipate, and ethyl acrylate. Inhalation of these chemicals specifically damages the olfactory mucosa of rodents. We report the localization and differential distribution of a 59 KD carboxylesterase in nasal tissues of the rat by immunohistochemistry. Rabbit antiserum against the 59 KD rat liver microsomal carboxylesterase bound most promin

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Stefani, Ambra, Alex Iranzo, Evi Holzknecht, et al. "Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder." Brain 144, no. 4 (2021): 1118–26. http://dx.doi.org/10.1093/brain/awab005.

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Abstract Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of patients with isolated RBD may identify those progressing to Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal of testing preventive therapies. Real-time quaking-induced conversion (RT-QuIC) provided evidence of α-synuclein seeding activity in CSF and olfactory mucosa of patients with α-synucleinopathies. The aim of this study was to explore RT-QuIC detectio

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Voigt, J. M., F. P. Guengerich, and J. Baron. "Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa." Journal of Histochemistry & Cytochemistry 41, no. 6 (1993): 877–85. http://dx.doi.org/10.1177/41.6.8315279.

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Cytochrome P450 1A1 was localized immunohistochemically and benzo[a]pyrene hydroxylase activity was identified in situ by means of fluorescence histochemistry in the nasal mucosa of untreated, 3-methylcholanthrene-treated or Aroclor 1254-treated rats. Cytochrome P450 1A1 was localized predominantly within Bowman's glands, with considerably less staining occurring in the olfactory epithelium of untreated rats. Similarly, benzo[a]pyrene was hydroxylated to the greatest extent in Bowman's glands and, to a lesser extent, in olfactory epithelial cells. Pre-treatment of tissue sections of nasal muco

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Guérout, Nicolas, Céline Derambure, Laurent Drouot, et al. "Comparative gene expression profiling of olfactory ensheathing cells from olfactory bulb and olfactory mucosa." Glia 58, no. 13 (2010): 1570–80. http://dx.doi.org/10.1002/glia.21030.

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Mellert, Tuesday K., Marilyn L. Getchell, Larry Sparks, and Thomas V. Getchell. "Characterization of the Immune Barrier in Human Olfactory Mucosa." Otolaryngology–Head and Neck Surgery 106, no. 2 (1992): 181–88. http://dx.doi.org/10.1177/019459989210600221.

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Immunologic defense factors in the human olfactory mucosa were localized immunohistochemically. Olfactory epithelium was identified with an antiserum to olfactory marker protein, specific for olfactory receptor neurons. Constituents of the secretory immune system, including IgA, IgM, secretory component, and J chain, were localized in the acinar and duct cells of Bowman's glands and in the mucociliary complex. In addition, B lymphocytes in the lamina propria near Bowman's glands displayed immunoreactivity for IgA, IgM, and J chain. Immunostaining also localized other humoral factors. Immunorea

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Verbeurgt, Christophe, Françoise Wilkin, Maxime Tarabichi, Françoise Gregoire, Jacques E. Dumont, and Pierre Chatelain. "Profiling of Olfactory Receptor Gene Expression in Whole Human Olfactory Mucosa." PLoS ONE 9, no. 5 (2014): e96333. http://dx.doi.org/10.1371/journal.pone.0096333.

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Ishimaru, Tadashi, Makoto Sakumoto, Yasuyuki Kimura, and Mitsuru Furukawa. "Olfactory Evoked Potentials Produced by Electrical Stimulation of the Olfactory Mucosa." Auris Nasus Larynx 23, no. 1 (1996): 98–104. http://dx.doi.org/10.1016/s0385-8146(96)80015-0.

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Toebbe, JT, and Mary Beth Genter. "An Update on Sphingosine-1-Phosphate and Lysophosphatidic Acid Receptor Transcripts in Rodent Olfactory Mucosa." International Journal of Molecular Sciences 23, no. 8 (2022): 4343. http://dx.doi.org/10.3390/ijms23084343.

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Olfactory neurons connect the external environment and the brain, allowing the translocation of materials from the nasal cavity into the brain. The olfactory system is involved in SARS-CoV-2 infections; early in the pandemic declared in 2020, a loss of the sense of smell was found in many infected patients. Attention has also been focused on the role that the olfactory epithelium appears to play in the entry of the SARS-CoV-2 virus into the brain. Specifically, SARS-CoV-2 enters cells via the angiotensin-converting enzyme 2 protein (ACE2), which is found on supporting cells in the olfactory ep

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DeJoia, Crista, Brian Moreaux, Kimberly O'Connell, and Richard A. Bessen. "Prion Infection of Oral and Nasal Mucosa." Journal of Virology 80, no. 9 (2006): 4546–56. http://dx.doi.org/10.1128/jvi.80.9.4546-4556.2006.

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ABSTRACT Centrifugal spread of the prion agent to peripheral tissues is postulated to occur by axonal transport along nerve fibers. This study investigated the distribution of the pathological isoform of the protein (PrPSc) in the tongues and nasal cavities of hamsters following intracerebral inoculation of the HY strain of the transmissible mink encephalopathy (TME) agent. We report that PrPSc deposition was found in the lamina propria, taste buds, and stratified squamous epithelium of fungiform papillae in the tongue, as well as in skeletal muscle cells. Using laser scanning confocal microsc

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Sánchez-Montañés, Manuel A., Julian W. Gardner, and Timothy C. Pearce. "Spatio-temporal information in an artificial olfactory mucosa." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 464, no. 2092 (2008): 1057–77. http://dx.doi.org/10.1098/rspa.2007.0140.

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Deploying chemosensor arrays in close proximity to stationary phases imposes stimulus-dependent spatio-temporal dynamics on their response and leads to improvements in complex odour discrimination. These spatio-temporal dynamics need to be taken into account explicitly when considering the detection performance of this new odour sensing technology, termed an artificial olfactory mucosa. For this purpose, we develop here a new measure of spatio-temporal information that combined with an analytical model of the artificial mucosa, chemosensor and noise dynamics completely characterizes the discri

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Getchell, Thomas V., N. S. Rama Krishna, D. Larry Sparks, Nimrat Dhooper, and Marilyn L. Getchell. "Human Olfactory Receptor Neurons Express Heat Shock Protein 70: Age-Related Trends." Annals of Otology, Rhinology & Laryngology 104, no. 1 (1995): 47–56. http://dx.doi.org/10.1177/000348949510400108.

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Immunocytochemical methods were used to investigate the cellular distribution and age-related trends in the expression of constitutive and/or inducible forms of heat shock protein (hsp) 70 in the human nasal mucosa of 22 subjects who ranged in age from 16 weeks prenatal to 90 years, including 3 subjects with Alzheimer's disease. The olfactory mucosa was characterized by the presence of olfactory marker protein—immunoreactive olfactory receptor neurons. The hsp 70 immunoreactivity was localized in olfactory receptor neurons and the supranuclear region of sustentacular cells in the olfactory epi

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Getchell, Thomas V., and Marilyn L. Getchell. "Regulatory factors in the vertebrate olfactory mucosa." Chemical Senses 15, no. 2 (1990): 223–31. http://dx.doi.org/10.1093/chemse/15.2.223.

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Robinson, Alan M., Robert C. Kern, Zygmunt S. Krozowski, James D. Foster, and Dimitri Z. Pitovski. "Mineralocorticoid Receptors in the Mammalian Olfactory Mucosa." Annals of Otology, Rhinology & Laryngology 108, no. 10 (1999): 974–81. http://dx.doi.org/10.1177/000348949910801009.

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