Relevant bibliographies by topics / Oral Disintegrating Tablets

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Academic literature on the topic 'Oral Disintegrating Tablets'

Author: Grafiati
Published: 4 June 2025
Last updated: 14 July 2025

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Journal articles on the topic "Oral Disintegrating Tablets"

1

Sneha, Ms Shinde. "Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 04 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem30535.

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Nowadays, the administration of drugs through the oral route is becoming less common, accounting for only about 75% of all drug administrations compared to other routes. A new type of dosage form called oral disintegrating tablets has gained popularity in recent decades due to their rapid disintegration and dissolution. These tablets disintegrate in the mouth within seconds (25-40 seconds) without the need for water, as the oral mucosa alone is sufficient for the tablet to dissolve. The selection of a suitable disintegrating agent is crucial to achieve optimal bioavailability. A preparation may contain one or multiple disintegrating agents to ensure maximum disintegration and bioavailability. These tablets are also known as Oro disintegration tablets. Disintegrating agents are rarely used in solid unit dosage forms, typically comprising only 1-10% of the total dosage unit. The use of super disintegrates in these tablets enhances the drug's efficacy by promoting rapid dissolution. Various disintegrating agents, super disintegrates, and excipients are employed in the formulation of oral disintegrating tablets. This review article provides an overview of different types of disintegrates, including natural, polymer, and synthetic ones, as well as formulation methods, applications, and various parameters of oral disintegrating tablets. These tablets are particularly well-liked by pediatric patients and those who prefer generic medications. Oral disintegrating tablets are highly preferred in the treatment of dysphagia and oral disorders among patients. Keywords: - Oral disintegrating tablets, Oro disintegrating tablets, Disintegrates, Super disintegrates and Fast dissolution tablet.
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2

M T, Ranjitha, and C. N. Somashekhar. "PREPARATION AND EVALUATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE AS ORAL DISINTEGRATING TABLET BY DIRECT COMPRESSION METHOD." Journal of Pharmaceutical and Scientific Innovation 10, no. 4 (2021): 94–101. http://dx.doi.org/10.7897/2277-4572.104211.

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A new dosage form, Oral disintegrating tablets (ODT’s) as a replacement to conventional oral dosage forms. ODT’s are dosage forms they disintegrate in mouth offering various advantages such as better mouth feel, dose accuracy, improved stability and convenient dosing as compared to oral liquids. So, there is need to designed oral disintegrating tablet to release the medicaments with an enhanced rate. Mefenamic acid is an anti- inflammatory drug while Dicyclomine HCl is anti-cholinergic drug. The combination of Mefenamic acid & Dicyclomine HCl controls pain very effectively, also relaxes bodily spasm which commonly arises during menstruation or intestinal colic spasm. This combination gives the quick onset of action and fast relief than conventional dosage form. For preparation of oral disintegrating tablet nine formulations were designed using Croscarmellose sodium and Crospovidone as superdisintegrants in varying concentration. All the formulations were prepared by direct compression method. Thus, all the formulations of Mefenamic acid and Dicyclomine HCl oral disintegrating tablets were investigated, in which F9 formulation was optimized. The % drug release of, Oral disintegrating tablet batch F9 has shown 96.98% of Mefenamic acid and 94.02 % of Dicyclomine HCl in 18 min, disintegration time in 40 sec and wetting time in 25sec.
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Eremin, V. A., E. V. Blynskaya, and V. V. Bueva. "Orally disintegrating tablets: mechanisms, preparation methods, problems and achievements." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 25–32. http://dx.doi.org/10.33920/med-13-2306-03.

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The oral route of drug administration is considered one of the preferred delivery methods. In recent years, orally disintegrating tablets (ODTs) have become convenient pharmaceutical dosage forms, especially for specific patient populations such as pediatric, geriatric, and psychiatric patients with dysphagia. Rapid disintegration and increased bioavailability are some of the essential characteristics of ODTs that make them superior to other traditional pharmaceutical dosage forms. Orally disintegrating tablets are pills that disintegrate within a few seconds after being placed in the oral cavity. This review describes the mechanisms of drug release from ODTs, manufacturing challenges, and advancements in orally disintegrating tablet technologies.
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Joshi, Apeksha, Narendra Gahelot, Vikas Jain, and SC Mahajan. "Rapid disintegrating tablets: an effective method for accelerating the therapeutic action of poorly soluble Drugs." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 208–13. http://dx.doi.org/10.22270/jddt.v12i1.5174.

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The ease of administration and increased patient compliance are critical factors in the design of oral drug delivery systems, which continue to be the dominant method of drug delivery despite numerous shortcomings. The rapid disintegrating tablet (RDT) could be a great alternative to traditional tablets because it dissolves quickly when it comes into contact with saliva. Rapid disintegrating tablets (RDTs) are currently more widely available than other tablets to treat various disorders. Due to its ease of manufacture and administration, oral administration is being investigated as the most frequently used route. Due to its rapid disintegration features, water-free use, and simplicity of swallowing, RDTs, particularly for pediatric patients, are effective drug delivery devices. Rapid disintegrating tablets are solid dosage forms that disintegrate in the mouth without water in less than 60 seconds. Rapid disintegration of tablets results in rapid dissolution and, thus, immediate action. The primary objective of this review paper is to discuss the benefits, drawbacks, formulation issues, manufacturing methods, patented technology and evaluation tests. Spray drying, freeze drying, direct compression, moulding, and sublimation are all traditional ways of preparation, however new technologies have been created for the production of RDTs.
 Keywords: Rapid disintegrating tablets, patient compliance, spray drying, freeze drying, direct compression.
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Patel, Afroza Akbar, Siraj N. Shaikh, Huzaifa Patel, Afzal Band, and Ahmed Shaoor. "Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 95–102. http://dx.doi.org/10.22270/jddt.v9i1.2176.

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The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables, concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared oral fast disintegrating tablets evaluated for Pre and Post-compression parameters. The prepared tablets exhibited satisfactory physico-chemical characterise especially fast disintegration & dissolution property. Full factorial design and optimization technique successfully used in the development oral fast disintegrating tablets. Comparing the all the formulations, formulation F9 was considered as optimized formulation which shows excellent fast disintegration, in vitro dissolution, and faster drug release within 6 min in comparison to other batches also stable in stability study.
 Keywords: Fast disintegrating, Ranitidine, Crosspovidone, Gum, Optimizations, Water absorption ratio
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Swarupa, Arvapalli* D. Swamy Shyamala. "ORAL DISINTEGRATION TABLETS – AN UPDATED REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6926–34. https://doi.org/10.5281/zenodo.2617331.

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<em>The purpose of writing this review is Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. It is leads to development of orally disintegrating tablets. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. The aim of this article is to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.</em>&nbsp; <strong>Key words: </strong><em>Orally disintegrating tablet, Oral route, Excipients.</em>
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Kumar, Y. Shravan, Karnakar M, Harika S, and Mounika M. "Formulation and Evaluation of Salbutamol Sulphate Taste Masked Oral Disintegrating Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (2021): 5571–76. http://dx.doi.org/10.37285/ijpsn.2021.14.4.7.

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Salbutamol is a short acting, selective beta2-adrenergic receptor agonist used in the treatment of astama and COPD. The aim of this study is to formulate oral disintegrating tablets of salbutamol sulphate to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Oral disintegrating tablets of salbutamol sulphate were designed with a view to enhance the patient compliance and provide a quick onset of action. The oral disintegrating tablets were prepared by using different synthetic polymers by direct compression method. Development of the formulation in the present study was based on the concentration of superdisintegrants and the properties of the drug. Nine batches of tablets were formulated and evaluated for various parameters: drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, hardness, friability, thickness uniformity, and in vitro dissolution. A fourier-transform infrared spectroscopy (FTIR) study showed that there were no significant interactions between the drug and the excipients. The prepared tablets were good in appearance and showed acceptable results for hardness and friability. The in vitro disintegrating time of the formulated tablets was found to be 14.39-32.41 sec and the drug content of tablets in all formulations was found to be between 87.48-99.96 %, which complied within the limits established in the Indian pharmacopeia. The study concluded that taste of the drug was masked with the help of sodium saccarhin, flavor and the concentration of super disintegrating agent increases the disintegration time of tablets get decreases. The formulation (F9) had a minimum disintegration time of 14.39 sec and 99.96 % of the drug was released within 20 min.
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8

Rakesh, Pahwa* Shwetakshi Sharma Abhinav Singh Rana Anshul Garg and Inderbir Singh. "EMERGENCE OF NATURAL SUPERDISINTEGRANTS IN THE DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 03, no. 08 (2016): 777–87. https://doi.org/10.5281/zenodo.153851.

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Orally disintegrating tablets have carved a significant role amongst the oral drug delivery systems owing to their enhanced patient compliance especially in the geriatrics and pediatrics. These tablets offer numerous substantial advantages over conventional dosage forms because of improved efficacy, bioavailability and rapid onset of action. Use of natural superdisintegrants in the development of orally disintegrating tablets has numerous benefits such as chemically inert, non-toxic, less expensive, biodegradable and widely available. The present manuscript is an earnest attempt to illustrate ideal properties, significance and formulation aspect of orally disintegrating tablets especially the use of superdisintegrants. Various natural superdisintegrants utilized in the development of orally disintegrating tablets have also been discussed. Keywords: Orally disintegrating tablets, Natural superdisintegrants, Gums, Mucilages, Disintegration time.
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&NA;. "Ondansetron Oral Disintegrating Tablets." Survey of Anesthesiology 50, no. 3 (2006): 143–44. http://dx.doi.org/10.1097/01.sa.0000220745.07169.7f.

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10

Chue, Pierre, Barry Jones, Cindy C. Taylor, and Ruth Dickson. "Dissolution Profile, Tolerability, and Acceptability of the Orally Disintegrating Olanzapine Tablet in Patients with Schizophrenia." Canadian Journal of Psychiatry 47, no. 8 (2002): 771–74. http://dx.doi.org/10.1177/070674370204700809.

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Objectives: This pilot study investigates the dissolution profile, tolerability, and acceptability of an orally disintegrating olanzapine tablet in patients with schizophrenia. Method: Eleven patients with schizophrenia stabilized on oral olanzapine (mean dosage 12.7 mg daily [SD5.2]) were given an orally disintegrating olanzapine tablet, rather than their usual tablet, daily for 7 days. At each visit, visual assessments were made for elapsed time to initial disintegration (every 15 seconds) and complete disintegration (every 1 minute). At the end of the study, patients completed a drug-acceptance questionnaire. Results: The mean time to initial disintegration was 15.78 seconds, and mean time to complete disintegration was 0.97 minutes. All patients found the orally disintegrating tablet acceptable and expressed positive comments. Nonserious clinically significant adverse events, asthenia, purpuric rash, headache, depression, and insomnia (preexisting, except for asthenia and insomnia) were reported in 3 patients. Conclusion: The orally disintegrating olanzapine tablet disintegrates rapidly and is a well-tolerated and acceptable alternative to standard olanzapine tablets in patients with schizophrenia.
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Book chapters on the topic "Oral Disintegrating Tablets"

1

Jeong, Seong Hoon, Jaehwi Lee, and Jong Soo Woo. "Fast Disintegrating Tablets." In Oral Controlled Release Formulation Design and Drug Delivery. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470640487.ch10.

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Ejeta, Fikadu. "Orally Disintegrating Tablets." In Dosage Forms - Innovation and Future Perspectives [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109892.

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Research and development costs for a single new pharmaceutical that is introduced to the market are estimated to cost between $1 billion and $2 billion. Due to the high cost of development and the need to quickly access various technologies, it is more cost-effective (clinically and financially) to enhance current pharmaceuticals for potency, selectivity, drug metabolism, and dosing convenience before they reach the market. Orally dissolving tablets have been developed as a result. Pharmaceutical companies have created oral disintegrating tablets that dissolve or disintegrate in the mouth within a few seconds of being placed there in order to maximize the safety and efficacy of the medicine molecule. Because patients with weak physiological (patients with mental illnesses) and physical capacities can easily administer it to geriatrics, children, and patients with these conditions (patients suffering from dysphagia), as well as traveling patients who may not have easy access to water and where swallowing conventional solid oral-dosage forms presents difficulties, it has grown in popularity among a wide population. These tablets can be prepared in many ways like direct compression, freeze drying, sublimation, molding, and spray drying by using single or combinations of superdisintegrants or subliming agents.
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3

Noothi, Sadhana, Narender Malothu, and P. Vishnu. "Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic Super Disintegrants." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00361.

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Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of action. In this study, an attempt was made to compare the effect of different natural and synthetic super disintegrants on the release profile of the formulation. The formulations (BF1-BF15) of BLS oral disintegrating tablets were prepared by direct compression technique using synthetic and natural super disintegrants (Chitosan, Fenugreek mucilage, Sodium starch glycolate, Ludiflash, Cross povidone) in three different concentrations (2, 4, and 6%). The formulated tablets were analyzed for pre-compression and post-compression parameters and in vitro drug release. The best formulation, F15 containing 6% Ludiflash as a super disintegrant, was found to have a maximum water absorption ratio and disintegration time and in vitro dissolution was found to be less than 5 min, ensuring faster disintegration and dispersion. The F15 formulation shows less disintegration and dispersion time because of its combined effect and formulation, which had a better drug release of 99.79% within 20 min. The dissolution pattern of various disintegrants used in the formulation was found to be in the order of Ludiflash&amp;gt;Cross povidone&amp;gt;chitosan&amp;gt;SSG&amp;gt;Fenugreek mucilage. Overall, the results show that the formulated oral disintegrating tablets of BLS with Ludiflash as a super disintegrant, indicating that this could be a feasible drug delivery for BLS.
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Kumar, Amit, Londhe Sachin Bhimrao, Abha Sharma, and Awesh K. Yadav. "Polymers in orally disintegrating tablets and orally dissolving films." In Polymers for Oral Drug Delivery Technologies. Elsevier, 2025. http://dx.doi.org/10.1016/b978-0-443-13774-7.00016-5.

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MANSUR, Dr RANI, and Dr MUKESH KUMAR KUMAWAT. "ORAL DISINTEGRATING TABLET." In NOVEL DRUG DELIVERY SYSTEM. GRF BOOKS, 2022. http://dx.doi.org/10.52458/9789391842871.2022.eb.grf.asu.ch.12.

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