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Relevant bibliographies by topics / Organelle contact sites

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Academic literature on the topic 'Organelle contact sites'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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Journal articles on the topic "Organelle contact sites"

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King, Christopher, Prabuddha Sengupta, Arnold Y. Seo, and Jennifer Lippincott-Schwartz. "ER membranes exhibit phase behavior at sites of organelle contact." Proceedings of the National Academy of Sciences 117, no. 13 (2020): 7225–35. http://dx.doi.org/10.1073/pnas.1910854117.

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The endoplasmic reticulum (ER) is the site of synthesis of secretory and membrane proteins and contacts every organelle of the cell, exchanging lipids and metabolites in a highly regulated manner. How the ER spatially segregates its numerous and diverse functions, including positioning nanoscopic contact sites with other organelles, is unclear. We demonstrate that hypotonic swelling of cells converts the ER and other membrane-bound organelles into micrometer-scale large intracellular vesicles (LICVs) that retain luminal protein content and maintain contact sites with each other through localiz

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Elbaz-Alon, Yael. "Mitochondria–organelle contact sites: the plot thickens." Biochemical Society Transactions 45, no. 2 (2017): 477–88. http://dx.doi.org/10.1042/bst20160130.

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Membrane contact sites (MCSs) are areas of close apposition between the membranes of two different organelles that enable non-vesicular transfer of ions and lipids. Recent studies reveal that mitochondria maintain contact sites with organelles other than the endoplasmic reticulum such as the vacuole, plasma membrane and peroxisomes. This review focuses on novel findings achieved mainly in yeast regarding tethers, function and regulation of mitochondria–organelle contact sites. The emerging network of MCSs linking virtually all cellular organelles is highly dynamic and integrated with cellular

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Mahen, Robert. "cNap1 bridges centriole contact sites to maintain centrosome cohesion." PLOS Biology 20, no. 10 (2022): e3001854. http://dx.doi.org/10.1371/journal.pbio.3001854.

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Centrioles are non-membrane-bound organelles that participate in fundamental cellular processes through their ability to form physical contacts with other structures. During interphase, two mature centrioles can associate to form a single centrosome—a phenomenon known as centrosome cohesion. Centrosome cohesion is important for processes such as cell migration, and yet how it is maintained is unclear. Current models indicate that pericentriolar fibres termed rootlets, also known as the centrosome linker, entangle to maintain centriole proximity. Here, I uncover a centriole–centriole contact si

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Prinz, William A. "Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics." Journal of Cell Biology 205, no. 6 (2014): 759–69. http://dx.doi.org/10.1083/jcb.201401126.

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Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, meta

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Klemm, Robin W. "Getting in Touch Is an Important Step: Control of Metabolism at Organelle Contact Sites." Contact 4 (January 2021): 251525642199370. http://dx.doi.org/10.1177/2515256421993708.

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Metabolic pathways are often spread over several organelles and need to be functionally integrated by controlled organelle communication. Physical organelle contact-sites have emerged as critical hubs in the regulation of cellular metabolism, but the molecular understanding of mechanisms that mediate formation or regulation of organelle interfaces was until recently relatively limited. Mitochondria are central organelles in anabolic and catabolic pathways and therefore interact with a number of other cellular compartments including the endoplasmic reticulum (ER) and lipid droplets (LDs). An in

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Henne, W. Mike. "Organelle remodeling at membrane contact sites." Journal of Structural Biology 196, no. 1 (2016): 15–19. http://dx.doi.org/10.1016/j.jsb.2016.05.003.

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Picca, Anna, Riccardo Calvani, Hélio José Coelho-Junior, Francesco Landi, Roberto Bernabei, and Emanuele Marzetti. "Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View." Cells 9, no. 3 (2020): 598. http://dx.doi.org/10.3390/cells9030598.

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Mitochondrial dysfunction and failing mitochondrial quality control (MQC) are major determinants of aging. Far from being standalone organelles, mitochondria are intricately related with cellular other compartments, including lysosomes. The intimate relationship between mitochondria and lysosomes is reflected by the fact that lysosomal degradation of dysfunctional mitochondria is the final step of mitophagy. Inter-organelle membrane contact sites also allow bidirectional communication between mitochondria and lysosomes as part of nondegradative pathways. This interaction establishes a function

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Zhemkov, Vladimir, Jen Liou, and Ilya Bezprozvanny. "Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites." Contact 4 (January 2021): 251525642110265. http://dx.doi.org/10.1177/25152564211026505.

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Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enrich

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Zwilling, Emma, and Fulvio Reggiori. "Membrane Contact Sites in Autophagy." Cells 11, no. 23 (2022): 3813. http://dx.doi.org/10.3390/cells11233813.

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Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of organelle biogenesis in various cell types. Several studies have shown that MCSs play a crucial role in the regulation of macroautophagy, an intracellular catabolic transport route that is characterized by the delivery of cargoes (proteins, protein complexes or aggregates, organelles and pathogens)

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Ovciarikova, Jana, Shikha Shikha, and Lilach Sheiner. "Nuclear Interactions: A Spotlight on Nuclear Mitochondrial Membrane Contact Sites." Contact 5 (January 2022): 251525642210962. http://dx.doi.org/10.1177/25152564221096217.

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Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of organelles including mitochondria, ER, plasma membrane, lysosomes, lipid droplets, peroxisome and endosome, to name a few. In fact, MCS are found between any pair of organelles studied to date, with common functions including lipid exchange, calcium signalling and organelle positioning in the cell. Work in the past year has started addressing the composition

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Dissertations / Theses on the topic "Organelle contact sites"

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Chao, Jesse Tzu-Cheng. "The endoplasmic reticulum diffusion barrier and inter-organelle contact sites." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45256.

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Serafini, Annalisa. "A FRET-based genome wide high content screen identifies a novel role for the Parkinson's disease gene LRRK2 as modulator of endoplasmic reticulum-mitochondria tethering." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422263.

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Inter-organelle communication is a key feature of eukaryotic cells and has been found to be fundamental in many different cellular processes. One of the best characterized interorganelle cross talk due to membrane contact sites is that between Endoplasmic Reticulum (ER) and mitochondria. Also referred to as mitochondria associated ER-membranes (MAMs) or Mitochondria-ER contact sites (MERCs), their existence was discovered 50 years ago through electron microscopic studies, but their functional significance started to emerge only in late 90s when the role of MERCs in calcium exchange from ER to

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Couto, Renata Lopes Familiar. "Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-12AE-3.

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Otto, Florian Bo. "Dissection of the molecular machinery of micro- and macronucleophagy." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-1297-C.

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Books on the topic "Organelle contact sites"

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Tagaya, Mitsuo, and Thomas Simmen, eds. Organelle Contact Sites. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4567-7.

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Tagaya, Mitsuo, and Thomas Simmen. Organelle Contact Sites: From Molecular Mechanism to Disease. Springer, 2017.

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Tagaya, Mitsuo, and Thomas Simmen. Organelle Contact Sites: From Molecular Mechanism to Disease. Springer, 2018.

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Book chapters on the topic "Organelle contact sites"

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Hanada, Kentaro. "Ceramide Transport from the Endoplasmic Reticulum to the Trans Golgi Region at Organelle Membrane Contact Sites." In Advances in Experimental Medicine and Biology. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4567-7_5.

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Simmen, Thomas, and Mitsuo Tagaya. "Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research." In Advances in Experimental Medicine and Biology. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4567-7_1.

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Calì, Tito, and Marisa Brini. "Split Green Fluorescent Protein–Based Contact Site Sensor (SPLICS) for Heterotypic Organelle Juxtaposition as Applied to ER– Proximities." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1262-0_23.

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Raimondi, Andrea, Nicolò Ilacqua, and Luca Pellegrini. "Liver inter-organelle membrane contact sites revealed by serial section electron tomography." In Methods in Cell Biology. Elsevier, 2023. http://dx.doi.org/10.1016/bs.mcb.2022.12.021.

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Dalton, David R. "Roots, Shoots, Leaves, and Grapes." In The Chemistry of Wine. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190687199.003.0015.

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As noted earlier and as anticipated by Charles and Francis Darwin it has been argued that plants sense the direction of gravity (gravitropism) by movement of starch granules found in cells called statocytes that contain compartments (organelles) called statoliths. The synthesis of statoliths appears to occur in the plastid (plant organelle) compartments called amyloplasts (Figure 7.1, 1). It has been suggested that this gravitropic signal then leads to movement of plant hormones such as indole-3-acetic acid (auxin) (Figure 7.2), through the phloem opposite to the pull of gravity to promote stem growth. Chloroplasts (Figure 7.1, 2) are cell compartments (plastids or organelles) in which photosynthesis is carried out. The process of photosynthesis, discussed more fully later, is accompanied by the production of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate (Pi) (Figure 7.3). ATP is consumed and converted to ADP and Pi in living systems. The cycle of production and consumption allows ATP to serve as an “energy currency” to pay for the reactions in living systems. Beyond this generally recognized critical function of chloroplasts, it has recently been pointed out that light/ dark conditions affect alternative splicing of genes which may be necessary for proper plant responses to varying light conditions. The organelles or plastids which contain the pigments for photosynthesis and the amyloplasts that store starch are only two of many kinds of plastids. Other plastids, leucoplasts for example, hold the enzymes for the synthesis of terpenes, and elaioplasts store fatty acids. Apparently, all plastids are derived from proplastids which are present in the pluripotent apical and root meristem cells. The cell wall (Figure 7.1, 3) is the tough, rigid layer that surrounds cells. It is located on the outside of the flexible cell membrane, thus adding fixed structure. A representation of a portion of the cell wall (as made up of cellulose and peptide cross-linking) is shown below in Figure 7.7. The cells will have different sizes as a function of where they are found (e.g., leaf, stalk, root), but in every case, the cell wall limits the size of the membrane that lies within.

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Benarroch, Eduardo E. "Vesicular Trafficking." In Neuroscience for Clinicians, edited by Eduardo E. Benarroch. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190948894.003.0007.

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Normal cell function depends on the appropriate synthesis, maturation, sorting, and delivery of fully processed proteins and other macromolecules to specific intracellular compartments; uptake of material from the cell exterior; and regulated intracellular processing and degradation of proteins, lipids, complex carbohydrates, abnormal aggregates, and senescent organelles. These fundamental functions involve secretory, endocytic, and autophagic pathways. The secretory pathway is responsible for protein maturation, sorting, and delivery of transmembrane and secreted proteins from their site of synthesis to their final destinations. Synaptic vesicle exocytosis is a special form of secretion that allows rapid communication between neurons. The endocytic pathway starts with the internalization of material via endosomes. Endosomal content can be transported back to the cell body, recycled to cell compartments, or delivered for degradation by the lysosome. Abnormal protein aggregates or damaged organelles undergo autophagy, which involves formation of an autophagosome and degradation by the lysosome. Impaired vesicular trafficking is a fundamental mechanism in a large number of neurodegenerative disorders, including hereditary spastic paraplegia, lower motor neuron syndromes, and Parkinson disease.

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Santos, Dilvani Oliveira, and Paulo Renato Zuquim Antas. "The Multifaceted Interface Between the Host Immune Cell and Mycobacterium Tuberculosis - Mitochondria at the Crux of the Matter." In Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051698122030007.

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Tuberculosis (TB) is a contagious infectious disease that is a major cause of morbidity, being one of the top 10 causes of death worldwide, and the leading one from a single infectious agent. Also called “White Plague” in the past, TB is an airborne disease, propagated when multibacillary people spread M. tuberculosis by coughing or sneezing. The disease typically affects the lungs (pulmonary TB), but can also affect other sites (extrapulmonary TB). TB is curable and preventable: about 85% of the people who develop the disease may be successfully treated with a 6-month multidrug regimen. The treatment has the additional benefit of preventing onward transmission. Macrophages are the first host cell to get in contact with M. tuberculosis. They also have important effector functions, regardless of whether the infection evolves to a chronic or latent form. However, M. tuberculosis evades host cell innate defense mechanisms, manipulates organelles and cell metabolism, as well as host cell death pathways. This complex interaction between the host cell and the bacillus determines the outcome of the infection. In this context, mitochondria and mitochondrial DNA (mtDNA) contribute to triggering cell death by necrosis. However, excessive necrosis may lead to tissue damage, which disrupts granulomas and benefits M. tuberculosis transmission. We intend to revisit the major aspects of this intricated and multifaceted interface between the host immune cell and M. tuberculosis and discuss how mitochondria are the crux of the matter

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Singh, Lata, and Mithalesh Kumar Singh. "Mitochondria and Eye." In Mitochondrial Diseases [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96368.

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Mitochondria are essential subcellular organelles and important key regulators of metabolism. Mammalian mitochondria contain their own DNA (mtDNA). Human mtDNA is remarkably small (16,569 bp) compared to nuclear DNA. Mitochondria promote aerobic respiration, an important part of energy metabolism in eukaryotes, as the site of oxidative phosphorylation (OXPHOS). OXPHOS occurs in the inner membrane of the mitochondrion and involves 5 protein complexes that sequentially undergo reduction-oxygen reactions ultimately producing adenosine triphosphate (ATP). Tissues with high metabolic demand such as lungs, central nervous system, peripheral nerves, heart, adrenal glands, renal tubules and the retina are affected preferentially by this critical role in energy production by mitochondrial disorders. Eye-affected mitochondrial disorders are always primary, but the role of mitochondrial dysfunction is now best understood in acquired chronic progressive ocular diseases. Recent advances in mitochondrial research have improved our understanding of ocular disorders. In this chapter, we will discuss the mitochondria in relation to eye diseases, ocular tumors, pathogenesis, and treatment modalities that will help to improve the outcomes of these conditions.

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Conference papers on the topic "Organelle contact sites"

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Ozolina, N. V. "THE ROLE MEMBRANE CONTACT SITES IN CELL LIFE." In The Second All-Russian Scientific Conference with international participation "Regulation Mechanisms of Eukariotic Cell Organelle Functions". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-318-1-77-79.

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Reports on the topic "Organelle contact sites"

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Ostersetzer-Biran, Oren, and Alice Barkan. Nuclear Encoded RNA Splicing Factors in Plant Mitochondria. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7592111.bard.

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Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development. These activities are dependent upon the tight regulation of the expression and accumulation of various organellar proteins. Plant mitochondria contain their own genomes (mtDNA), which encode for a small number of genes required in organellar genome expression and respiration. Yet, the vast ma

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Stern, David B., and Gadi Schuster. Manipulation of Gene Expression in the Chloroplast: Control of mRNA Stability and Transcription Termination. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568750.bard.

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Chloroplasts are the site of photosynthesis and of other essential biosynthetic activities in plant cells. Chloroplasts are semi-autonomous organelles, since they contain their own genomes and protein biosynthetic machinery, but depend on the coordinate expression of nuclear genes to assemble macromolecular complexes. The bioeingineering of plants requires manipulation of chloroplast gene expression, and thus a knowledge of the molecular mechanisms that modulate mRNA and protein production. In this proposal the heterotrophic green alga Chlamydomonas reinhardtii has been used as a model system

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Ostersetzer-Biran, Oren, and Jeffrey Mower. Novel strategies to induce male sterility and restore fertility in Brassicaceae crops. United States Department of Agriculture, 2016. http://dx.doi.org/10.32747/2016.7604267.bard.

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Abstract Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development. These activities are dependent upon the tight regulation of the expression and accumulation of various organellar proteins. Plant mitochondria contain their own genomes (mtDNA), which encode for rRNAs, tRNAs and some mitochondrial proteins. Although all mitochondria have probably evo

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