Academic literature on the topic 'P53 tumour suppressor protein'

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Dissertations / Theses on the topic "P53 tumour suppressor protein"

1

Marston, Nicola Jane. "Mutational analysis of the tumour suppressor protein, p53." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387679.

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2

Protopopova, Marina. "Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-926-9/.

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3

Husaini, Roslina. "Towards the Investigation of the Effects of Nitration on the Activity of the Human p53 Tumour Suppressor Protein. Nitration of the p53 Tumour Suppressor Protein." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14788.

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Upon responding to cellular stress, p53 protein becomes stabilised and acts as a transcription factor mainly resulting from phosphorylation and acetylation of the protein. Nitration of p53 protein is poorly characterised by comparison with phosphorylation and acetylation. The main aim of this work was to study the effects of nitration on p53 functional activities and on p53-MDM2 protein-protein interactions. Preliminary work was to characterise the nitration of p53 protein over-expressed in E. coli BL21(DE3) which was then purified by a series of column chromatography. GST-MDM2 protein along w
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4

Cuella-Martin, Raquel. "Molecular regulation of p53-dependent tumour suppressor responses by the p53 binding protein 1." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:7b2e64f3-bda4-4c3c-aeaf-d27393b7bc07.

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The tumour suppressor p53 binding protein 1 (53BP1), a fundamental node in DNA double strand break (DSB) repair, was identified as a p53-interacting protein over two decades ago. However, its contribution to p53-dependent responses has remained largely enigmatic. Here, using a combination of detailed structure-function approaches and in vivo analyses I aim to unravel this aspect of 53BP1 functionality. I showed 53BP1 to enhance genome-wide p53-dependent transactivation events in response to multiple stress stimuli. Oligomerised 53BP1 relies on the tandem BRCT domain, dispensable for 53BP1-driv
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5

Rajagopalan, Sridharan. "Biophysical characterization of tumour suppressor p53 and its protein-interaction network." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608428.

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6

Jowsey, Paul Andrew. "The role of poly(ADP-ribose) polymerase-1 in the MDM2-p53 DNA damage response pathway." Thesis, University of Newcastle Upon Tyne, 2003. http://hdl.handle.net/10443/1005.

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p53 is a tumour suppressor protein that is stabilised and activated by DNA damage. DNA damage-induced p53 is able to bring about either cell cycle arrest or apoptosis by the induction of p53-responsive genes such as mdm2 and p21 waf-I. Mdm2 regulates p53 function by blocking the transcriptional transactivation domain of p53 and also by targeting p53 for degradation via an ubiquitin-mediated pathway. Increases in the levels and activity of p53 are brought about by post-translational modifications. The most widely studied modification of p53 is phosphorylation, mediated by several DNA damageacti
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7

Liu, Geng. "Control of the p53 tumour suppressor protein through the NEDD8 conjugation pathway." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505643.

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8

Mee, Trevor Richard. "Analysis of the proteolytic cleavage reaction of the tumour suppressor protein p53." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310987.

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9

Baloglu, Cetin. "N terminal and DNA binding domain interactions of tumour suppressor protein p53." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608567.

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10

Heberling, Matthew Michael. "Improving stability of tumor suppressor protein, p53." Connect to resource, 2007. http://hdl.handle.net/1811/28445.

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Thesis (Honors)--Ohio State University, 2007.<br>Title from first page of PDF file. Document formatted into pages: contains 25 p.; also includes graphics. Includes bibliographical references (p. 23-25). Available online via Ohio State University's Knowledge Bank.
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