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Journal articles on the topic 'PAF-Like Lipids'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Guarino, Michele P. L., Zuo-Liang Xiao, Piero Biancani, and Jose Behar. "PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 6 (2003): G1189—G1197. http://dx.doi.org/10.1152/ajpgi.00200.2003.

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H2O2 stimulates gallbladder muscle contraction and scavengers of free radicals through the generation of PGE2. Oxidative stress causes lipid peroxidation and generation of platelet-activating factor (PAF) or PAF-like lipids. The present studies therefore were aimed at determining whether either one induced by H2O2 mediates the increased generation of PGE2. Dissociated muscle cells of guinea pig gallbladder were obtained by enzymatic digestion. Both PAF-like lipids and PAF-induced muscle contraction was blocked by the PAF receptor antagonist CV-3988. This antagonist also blocked the increased P

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Foulks, Jason M., Gopal K. Marathe, Noemi Michetti, et al. "PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids." Blood 113, no. 26 (2009): 6699–706. http://dx.doi.org/10.1182/blood-2008-11-186312.

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Abstract Platelet activating factor (PAF) and PAF-like lipids induce inflammatory responses in target cells. These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH). The PAF signaling system affects the growth of hematopoietic CD34+ cells, but roles for PAF-AH in this process are unknown. Here, we investigated PAF-AH function during megakaryopoiesis and found that human CD34+ cells accumulate this enzymatic activity as they differentiate toward megakaryocytes, consistent with the expression of mRNA and protein for the plasma PAF-AH isoform. Inhibition of endogenous PAF-AH activit

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ANTONOPOULOU, Smaragdi, Alexandra OIKONOMOU, Haralabos C. KARANTONIS, Elizabeth FRAGOPOULOU, and Adriani PANTAZIDOU. "Isolation and structural elucidation of biologically active phospholipids from Scytonema julianum (cyanobacteria)." Biochemical Journal 367, no. 1 (2002): 287–93. http://dx.doi.org/10.1042/bj20020146.

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The role of platelet-activating factor (PAF) as a mediator appeared in rather primitive organisms like protozoans and was maintained in more evolved organisms. No reports exist for the presence of PAF or PAF analogues—or even compounds that exhibit PAF-like activity—in cyanobacteria, even though they belong to a a group of organisms at a low evolutionary level where the content of alkylacyl forms of ether lipids is expected to be high. In addition, cyanobacteria serve as a rich source of novel bioactive metabolites. In the present study the total lipids of a strain of Scytonema julianum, a fil

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Deng, Meng, Haitao Guo, Jason W. Tam, et al. "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." Journal of Experimental Medicine 216, no. 12 (2019): 2838–53. http://dx.doi.org/10.1084/jem.20190111.

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The role of lipids in inflammasome activation remains underappreciated. The phospholipid, platelet-activating factor (PAF), exerts multiple physiological functions by binding to a G protein–coupled seven-transmembrane receptor (PAFR). PAF is associated with a number of inflammatory disorders, yet the molecular mechanism underlying its proinflammatory function remains to be fully elucidated. We show that multiple PAF isoforms and PAF-like lipids can activate the inflammasome, resulting in IL-1β and IL-18 maturation. This is dependent on NLRP3, ASC, caspase-1, and NEK7, but not on NLRC4, NLRP1,

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Quinn, Robert A., Mark J. A. Vermeij, Aaron C. Hartmann, et al. "Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence." Proceedings of the Royal Society B: Biological Sciences 283, no. 1829 (2016): 20160469. http://dx.doi.org/10.1098/rspb.2016.0469.

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Holobionts are assemblages of microbial symbionts and their macrobial host. As extant representatives of some of the oldest macro-organisms, corals and algae are important for understanding how holobionts develop and interact with one another. Using untargeted metabolomics, we show that non-self interactions altered the coral metabolome more than self-interactions (i.e. different or same genus, respectively). Platelet activating factor (PAF) and Lyso-PAF, central inflammatory modulators in mammals, were major lipid components of the coral holobionts. When corals were damaged during competitive

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Marathe, Gopal K., and Cletus J. M. D'Souza. "Production of oxygen free radicals by Ehrlich ascites tumour cells: effect of lipids." Mediators of Inflammation 2, no. 1 (1993): 53–57. http://dx.doi.org/10.1155/s0962935193000079.

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Phorbol-12-myristate-13-acetate (PMA), calcium ionophore A23187 and platelet activating factor (PAF) stimulated the generation of oxygen free radicals (nitro-blue tetrazolium reduction) in Ehrlich ascites tumour (EAT) cells. PAF was effective at an optimal concentration of 4 μM, but was inhibited by BN 52021, a specific PAF antagonist. Lyso-PAF was ineffective. Inclusion of different lipids during incubation prior to the addition of PAF, resulted in the activation/inhibition of free radical generation. Among the phospholipids at a concentration of 50 μg/ml, the order of activation was phosphat

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Ocana, Jesus, Quiaofang Yi, Yongxue Yao, Paul Bryce, Mark Kaplan, and Jeffrey Travers. "Mast cell-derived histamine is necessary for platelet-activating factor mediated systemic immunosuppression (IRC4P.606)." Journal of Immunology 194, no. 1_Supplement (2015): 57.23. http://dx.doi.org/10.4049/jimmunol.194.supp.57.23.

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Abstract Platelet-activating Factor (PAF) activates many cell types via the G-protein coupled PAF-receptor (PAF-R). Systemic PAF-R activation exerts acute pro-inflammatory, as well as delayed systemic immunosuppressive effects in vivo. PAF enzymatic synthesis and degradation is tightly regulated, but reactive oxygen species from oxidative stressors, such as UVB, chemotherapy and cigarette smoke, generate PAF-like species via the unregulated oxidation of membrane lipids. The systemic immunosuppressive effects of these pro-oxidative stressors are due to PAF-R signaling. This work establishes the

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Marathe, Gopal K., Guy A. Zimmerman, Stephen M. Prescott, and Thomas M. McIntyre. "Activation of vascular cells by PAF-like lipids in oxidized LDL." Vascular Pharmacology 38, no. 4 (2002): 193–200. http://dx.doi.org/10.1016/s1537-1891(02)00169-6.

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Satoh, K., T. Imaizumi, H. Yoshida, M. Hiramoto, and S. Takamatsu. "Increased levels of blood platelet-activating factor (PAF) and PAF-like lipids in patients with ischemic stroke." Acta Neurologica Scandinavica 85, no. 2 (1992): 122–27. http://dx.doi.org/10.1111/j.1600-0404.1992.tb04010.x.

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Tsoupras, Alexandros, Donal Moran, Hayley Pleskach, Maria Durkin, Con Traas, and Ioannis Zabetakis. "Beneficial Anti-Platelet and Anti-Inflammatory Properties of Irish Apple Juice and Cider Bioactives." Foods 10, no. 2 (2021): 412. http://dx.doi.org/10.3390/foods10020412.

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Several bioactives from fruit juices and beverages like phenolics, nucleotides and polar lipids (PL) have exhibited anti-platelet cardio-protective properties. However, apple juice and cider lipid bioactives have not been evaluated so far. The aim of this study was to investigate the anti-platelet and anti-inflammatory effects and structure activity relationships of Irish apple juice and Real Irish cider lipid bioactives against the platelet-activating factor (PAF)- and adenosine diphosphate (ADP)-related thrombotic and inflammatory manifestations in human platelets. Total Lipids (TL) were ext

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GUARINO, M., Z. XIAO, P. BIANCANI, and J. BEHAR. "PAF-like lipids and PAF induced gallbladder (GB) muscle contraction are mediated by different pathways in guinea pigs." Gastroenterology 120, no. 5 (2001): A207. http://dx.doi.org/10.1016/s0016-5085(01)81030-1.

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Guarino, Michele Pier Luca, Zuo-Liang Xiao, Piero Biancani, and Jose Behar. "PAF-like lipids and PAF induced gallbladder (GB) muscle contraction are mediated by different pathways in guinea pigs." Gastroenterology 120, no. 5 (2001): A207. http://dx.doi.org/10.1016/s0016-5085(08)81030-x.

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Antonopoulou, Smaragdi, Charis E. Semidalas, Stamatis Koussissis, and Constantinos A. Demopoulos. "Platelet-Activating Factor (PAF) Antagonists in Foods: A Study of Lipids with PAF or Anti-PAF-like Activity in Cow's Milk and Yogurt." Journal of Agricultural and Food Chemistry 44, no. 10 (1996): 3047–51. http://dx.doi.org/10.1021/jf950619y.

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Frostegård, J., Y. H. Huang, R. Wu, and L. Schäfer-Elinder. "Proinflammatory cytokines in atherosclerotic plaques are induced by LysoPC AND PAF-like lipids." Atherosclerosis 151, no. 1 (2000): 261. http://dx.doi.org/10.1016/s0021-9150(00)81180-6.

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WU, Xiaoqing, Thomas M. McINTYRE, Guy A. ZIMMERMAN, Stephen M. PRESCOTT, and Diana M. STAFFORINI. "Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages." Biochemical Journal 375, no. 2 (2003): 351–63. http://dx.doi.org/10.1042/bj20030636.

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Plasma platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase that inactivates platelet-activating factor (PAF) and PAF-like lipids to generate products with little or no biological activity. The levels of circulating PAF-AH correlate with several disease syndromes. We previously reported that mediators of inflammation regulate the expression of the human PAF-AH gene at the transcriptional level. In the present paper, we characterize the constitutive expression of plasma PAF-AH using the mouse gene as a model system, and we report comparative results obtained using human and mo

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Shigematsu, Sakuji, Shuji Ishida, Dean C. Gute, and Ronald J. Korthuis. "Concentration-dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesentery." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 1 (1999): H152—H160. http://dx.doi.org/10.1152/ajpheart.1999.277.1.h152.

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The results of several recent studies indicate that bradykinin protects tissues against the deleterious effects of ischemia-reperfusion (I/R). However, other studies indicate that bradykinin can act as a proinflammatory agent, inducing P-selectin expression, the formation of chemotactic stimuli, and endothelial barrier disruption. In the present study, we used intravital microscopic techniques to examine the dose-dependent effects of bradykinin on leukocyte-endothelial cell interactions, the formation of platelet-leukocyte aggregates, and venular hemodynamics in rat mesentery in an attempt to

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Benitez, Sonia, Núria Puig, José Rives, Arnau Solé, and José Luis Sánchez-Quesada. "Can Electronegative LDL Act as a Multienzymatic Complex?" International Journal of Molecular Sciences 24, no. 8 (2023): 7074. http://dx.doi.org/10.3390/ijms24087074.

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Electronegative LDL (LDL(−)) is a minor form of LDL present in blood for which proportions are increased in pathologies with increased cardiovascular risk. In vitro studies have shown that LDL(−) presents pro-atherogenic properties, including a high susceptibility to aggregation, the ability to induce inflammation and apoptosis, and increased binding to arterial proteoglycans; however, it also shows some anti-atherogenic properties, which suggest a role in controlling the atherosclerotic process. One of the distinctive features of LDL(−) is that it has enzymatic activities with the ability to

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Tsoupras, Alexandros, Paschalis Cholidis, Dimitrios Kranas, et al. "Anti-Inflammatory, Antithrombotic, and Antioxidant Properties of Amphiphilic Lipid Bioactives from Shrimp." Pharmaceuticals 18, no. 1 (2024): 25. https://doi.org/10.3390/ph18010025.

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Background/Objectives: Marine organisms, including shrimps, have gained research interest due to containing an abundance of bioactive lipid molecules.This study evaluated the composition and the in vitro biological activities of amphiphilic bioactive compounds from four different wild shrimp species: Litopenaeus vannamei, Penaeus kerathurus, Aristaeomorpha foliacea, and Parapenaeus longirostris. Methods: Total lipid (TL) extracts were obtained from shrimp and separated into total amphiphilic (TAC) and total lipophilic (TLC) compounds. Phenolic (TPC) and carotenoid (TCC) contents, antioxidant a

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Moran, Donal, Mary Fleming, Eimear Daly, et al. "Anti-Platelet Properties of Apple Must/Skin Yeasts and of Their Fermented Apple Cider Products." Beverages 7, no. 3 (2021): 54. http://dx.doi.org/10.3390/beverages7030054.

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Alcoholic beverages like apple cider are considered functional beverages with several health benefits, when consumed in moderation, which are mainly attributed to their microbiota and the plethora of their bioactive compounds. Among them, bio-functional polar lipids (PL) have recently been found in apple cider, which despite low quantities, have exhibited strong anti-inflammatory and anti-platelet properties, while fermentation seems to affect the functionality of apple cider’s PL bioactives. The aim of the present study was to elaborate yeast strains isolated from the complex mixtures of appl

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Marra, Anita, Vasileios Manousakis, Nikolaos Koutis, et al. "In Vitro Antioxidant, Antithrombotic and Anti-Inflammatory Activities of the Amphiphilic Bioactives Extracted from Avocado and Its By-Products." Antioxidants 14, no. 2 (2025): 146. https://doi.org/10.3390/antiox14020146.

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The antioxidant, antithrombotic and anti-inflammatory effects of the amphiphilic compounds extracted from both avocado juice and by-products, were evaluated. All extracts were assessed for their total phenolic content (TPC) and total carotenoid content (TCC), and for their antioxidant activities by DPPH, ABTS and FRAP assays as well as for their anti-inflammatory and antithrombotic potency in human platelets. The extracts rich in TAC (Total Amphiphilic Content) showed much higher content in phenolics and carotenoids from the extracts of total lipophilic content (TLC), which was reflected by th

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Cong, Ping, Zuo-Liang Xiao, Piero Biancani, and Jose Behar. "Reactive oxygen species are messengers in maintenance of human and guinea pig gallbladder tonic contraction." American Journal of Physiology-Gastrointestinal and Liver Physiology 293, no. 6 (2007): G1244—G1251. http://dx.doi.org/10.1152/ajpgi.00206.2007.

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The tonic contraction of human and guinea pig gallbladder (GB) is dependent on basal levels of PGE2 and thromboxane A2 (TxA2). The pathway involved in the genesis of these prostaglandins has not been elucidated. We aimed to examine the source of reactive oxygen species (ROS) and whether they contribute to the genesis of GB tonic contraction by generating basal prostaglandin levels. Tonic contraction was studied in human and guinea pig GB muscle strips treated with ROS scavengers (Tiron and catalase), apocynin (an inhibitor of NADPH oxidase), and NOX-1 small interference RNA (siRNA). The subuni

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Papadopoulou, Dimitra, Vasiliki Chrysikopoulou, Aikaterini Rampaouni, et al. "Antioxidant, Antithrombotic and Anti-Inflammatory Properties of Amphiphilic Bioactives from Water Kefir Grains and Its Apple Pomace-Based Fermented Beverage." Antioxidants 14, no. 2 (2025): 164. https://doi.org/10.3390/antiox14020164.

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Kefir-based fermentation products exhibit antioxidant and anti-inflammatory effects against oxidative stress, inflammation, platelet activation and aggregation, and other related manifestations, thereby preventing the onset and development of several chronic diseases. Specifically, water kefir, a symbiotic culture of various microorganisms used for the production of several bio-functional fermented products, has been proposed for its health-promoting properties. Thus, water kefir grains and its apple pomace-based fermentation beverage were studied for bioactive amphiphilic and lipophilic lipid

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Antonopoulou, Smaragdi, Alexandros Tsoupras, George Baltas, Helen Kotsifaki, Zacharias Mantzavinos, and Constantinos A. Demopoulos. "Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients." Mediators of Inflammation 12, no. 4 (2003): 221–27. http://dx.doi.org/10.1080/09629350310001599666.

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Periodontal diseases are localized chronic inflammatory conditions of the gingival and underlying bone and connective tissue. Platelet-activating factor (PAF), a potent inflammatory phospholipid mediator that has been previously detected in elevated levels in inflamed gingival tissues, in gingival crevicular fluid and in saliva, is implicated in periodontal disease. Our results from previous studies showed that the biologically active phospholipid detected in gingival crevicular fluid is a hydroxyl-PAF analogue. In this study, hydroxyl-PAF analogue was detected for the first time in human bloo

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Walterscheid, Jeffrey P., Stephen E. Ullrich, and Dat X. Nghiem. "Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression." Journal of Experimental Medicine 195, no. 2 (2002): 171–79. http://dx.doi.org/10.1084/jem.20011450.

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Ultraviolet (UV) radiation plays a critical role in the induction of nonmelanoma skin cancer. UV radiation is also immune suppressive, and the immune suppression induced by UV irradiation has been identified as a major risk factor for skin cancer induction. Previously, we showed that UV exposure activates a cytokine cascade involving prostaglandin (PG)E2, interleukin (IL)-4, and IL-10 that induces immune suppression. However, the earliest molecular events that occur immediately after UV exposure, especially those upstream of PGE2, are not well defined. UV-irradiated keratinocytes secrete the i

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Barbuti, Andrea, Satoshi Ishii, Takao Shimizu, Richard B. Robinson, and Steven J. Feinmark. "Block of the background K+ channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 6 (2002): H2024—H2030. http://dx.doi.org/10.1152/ajpheart.00956.2001.

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Platelet-activating factor (PAF), an inflammatory phospholipid, induces ventricular arrhythmia via an unknown ionic mechanism. We can now link PAF-mediated cardiac electrophysiological effects to inhibition of a two-pore domain K+ channel [TWIK-related acid-sensitive K+background channel (TASK-1)]. Superfusion of carbamyl-PAF (C-PAF), a stable analog of PAF, over murine ventricular myocytes causes abnormal automaticity, plateau phase arrest of the action potential, and early afterdepolarizations in paced and quiescent cells from wild-type but not PAF receptor knockout mice. C-PAF-dependent cur

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Jancar, Sonia, and Roger Chammas. "PAF Receptor and Tumor Growth." Current Drug Targets 15, no. 10 (2014): 982–87. http://dx.doi.org/10.2174/1389450115666140903111812.

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The receptor for the lipid mediator PAF (PAFR) is a G-protein coupled receptor expressed in several cell types. Besides PAF, a series of oxidized phospholipids can also bind to PAFR. Dying cells also express PAFR-ligands and, in both situations, scavenger receptors are involved as well. There is evidence that the scavenger receptor CD36 and PAFR associate in the macrophages membrane and signal in conjunction to induce a regulatory phenotype. In the tumor microenvironment, apoptotic cells are abundant due to hypoxia, and PAF-like phospholipids are generated. Engagement of PAFR expressed by tumo

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Imaizumi, Tada-atsu. "Intravascular release of a platelet-activating factor-like lipid (PAF-LL) induced by cigarette smoking." Lipids 26, no. 12 (1991): 1269–73. http://dx.doi.org/10.1007/bf02536545.

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van der Bruggen, T., P. T. Kok, J. A. Raaijmakers, J. W. Lammers, and L. Koenderman. "Cooperation between Fc gamma receptor II and complement receptor type 3 during activation of platelet-activating factor release by cytokine-primed human eosinophils." Journal of Immunology 153, no. 6 (1994): 2729–35. http://dx.doi.org/10.4049/jimmunol.153.6.2729.

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Abstract After priming with cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, or IL-5, eosinophils are stimulated potently by opsonized particles like serum-treated zymosan (STZ), resulting in activation of the respiratory burst and production of lipid mediators, such as platelet-activating factor (PAF) and leukotriene C4 (LTC4). In the present study, the role of the opsonin receptors Fc gamma RII and CR3 during both STZ-induced activation of the respiratory burst and PAF release by human eosinophils was investigated. Inhibition studies with blocking mAbs (alp

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Morton, Jude S., Anita Quon, Po-Yin Cheung, Tatsuya Sawamura, and Sandra T. Davidge. "Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 3 (2015): R163—R172. http://dx.doi.org/10.1152/ajpregu.00222.2014.

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Preeclampsia is a disorder of pregnancy with a significant impact on maternal and fetal health. The complexity of this multifactorial condition has precluded development of effective therapies and, although many potential pathways have been investigated, the etiology still requires clarification. Our group has investigated the scavenger lectin-like oxidized LDL (LOX-1) receptor, which may respond to factors released from the distressed placenta that contribute to the vascular pathologies observed in preeclampsia. Given the known beneficial effects of sodium tanshinone IIA sulfonate (STS; a com

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Puig, Núria, Jose Rives, Montserrat Estruch, et al. "Presence of Ceramidase Activity in Electronegative LDL." International Journal of Molecular Sciences 24, no. 1 (2022): 165. http://dx.doi.org/10.3390/ijms24010165.

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Electronegative low-density lipoprotein (LDL(−)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them is increased bioactive lipid mediator content, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), which are related to the presence of some phospholipolytic activities, including platelet-activating factor acetylhydrolase (PAF-AH), phospholipase C (PLC), and sphingomyelinase (SMase), in LDL(−). However, these enzymes’ activities do not explain the increased Sph content, which typically der

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Shah, Ketan Jaysukhlal, and B. Linganwad Saidas. "Analysis of Rupatadine in Reduction of Dengue Haemorrhagic Fever among the Patients with Acute Dengue." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 2320–26. https://doi.org/10.5281/zenodo.12536616.

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<strong>Introduction:</strong> In dengue hemorrhagic fever (DHF), patients may have organ damage and endothelial dysfunction that results in vascular leak. The dengue NS1 protein, several inflammatory cytokines including IL-1β as well as TNF-α, inflammatory lipid mediators like platelet activating factor (PAF). Rupatadine, an oral second-generation antihistamine, competitively inhibits both histamine and PAF receptors and has not been associated with any negative cardiac consequences in people from Europe and Asia. <strong>Aims and Objectives:</strong> To analyze the

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Robertson, Sarah A., Hanan H. Wahid, Peck Yin Chin, Mark R. Hutchinson, Lachlan M. Moldenhauer, and Jeffrey A. Keelan. "Toll-like Receptor-4: A New Target for Preterm Labour Pharmacotherapies?" Current Pharmaceutical Design 24, no. 9 (2018): 960–73. http://dx.doi.org/10.2174/1381612824666180130122450.

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Inflammatory activation, a major driver of preterm birth and subsequent neonatal morbidity, is an attractive pharmacological target for new preterm birth therapeutics. Inflammation elicited by intraamniotic infection is causally associated with preterm birth, particularly in infants delivered ≤34 weeks’ gestation. However, sterile triggers of PTB, including placental ischaemic injury, uterine distention, cervical disease, or imbalance in the immune response, also act through inflammatory mediators released in response to tissue damage. Toll-like Receptors (TLRs) are critical upstream gate-keep

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Altura, BM, W. Li, A. Zhang, et al. "The Expression of Platelet-Activating Factor is Induced by Low Extracellular Mg2+ in Aortic, Cerebral and Neonatal Coronary Vascular Smooth Muscle; Cross Talk with Ceramide Production, NF–kB and Proto-Oncogenes: Possible Links to Atherogenesis and Sudden Cardiac Death in Children and Infants, and Aging; Hypothesis, Review and Viewpoint." March 31, 2016. https://doi.org/10.19070/2470-4563-1600011.

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An attempt is made, herein, to reconcile, and integrate, various phenomena associated with magnesium deficiency (MgD) in cardiovascular health, disease, and aging as well as reasons for the high incidence of sudden cardiac death in infants and young adults. With new experiments, we demonstrate, for the first time, that very low concentrations of platelet-activating factor (PAF), when added to primary cultured cerebral, neonatal coronary, and aortic vascular smooth muscle (VSM) cells (from three different mammals) promote rapid rises in free intracellular Ca2+ ions and a significant, concomitan

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Ferrannini, Ele, Maria Laura Manca, Giulia Ferrannini, et al. "Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans." Frontiers in Cardiovascular Medicine 8 (February 4, 2022). http://dx.doi.org/10.3389/fcvm.2021.790289.

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BackgroundProteomics of atypical phenotypes may help unravel cardiovascular disease mechanisms.AimWe aimed to prospectively screen the proteome of four types of individuals: with or without coronary artery disease (CAD), each with or without multiple risk factors. Associations with individual risk factors and circulating biomarkers were also tested to provide a functional context to the protein hits.Materials and MethodsThe CAPIRE study (ClinicalTrials.gov Identifier: NCT02157662) is a cross-sectional study aimed at identifying possible new mechanisms promoting or protecting against atherothro

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Tanaka, Shuto, Masataka Kawakita, Hikaru Yasui, et al. "An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice." Communications Biology 7, no. 1 (2024). http://dx.doi.org/10.1038/s42003-024-06498-7.

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AbstractAcute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and

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Thyagarajan‐Sahu, Anita, та Ravi P. Sahu. "Aspirin attenuates melanoma tumor growth via PGF2α‐SOX‐2 dependent pathways". FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.807.6.

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IntroductionExposure to pro‐oxidative stressors including cancer therapies via its ability to generate reactive oxygen species (ROS) produce potent oxidized lipid mediator, platelet‐activating factor (PAF) and PAF‐like agonists. We have shown that these PAF‐agonists significantly: 1) augmented the growth of subcutaneously implanted murine B16F10 melanoma tumors in a PAF‐receptor (PAF‐R) dependent manner; 2) impeded the efficacy of cancer chemotherapeutic agents and radiation therapy in murine melanoma models and; 3) detected in the perfusates and tumors collected from chemotherapy and radiatio

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Li, Xia, Wenhang Zhou, Dianxuan Guo, Youdong Hu, Hualan Zhou, and Ying Chen. "Cardiac Radiofrequency Ablation Exacerbates Myocardial Injury through Pro-Inflammatory Response and Pro-Oxidative Stress in Elderly Patients with Persistent Atrial Fibrillation." Current Vascular Pharmacology 22 (January 10, 2024). http://dx.doi.org/10.2174/0115701611257644231215071611.

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Background: There is a need to assess myocardial damage after radiofrequency ablation of the pulmonary veins (PV) for persistent atrial fibrillation (PAF) in elderly patients. Objective: To evaluate oxidative stress, inflammatory response and myocardial damage in elderly patients with PAF after radiofrequency ablation of the PV. Methods: High-sensitivity troponin T (hsTnT), malondialdehyde-modified low-density lipoprotein (MDA-LDL), acrolein (ACR), lipid hydroperoxide (LHP), toll-like receptor 4 (TLR4), soluble growth stimulation expressed gene 2 (sST2), angiotensin II (Ang II) and myocardial

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Cerutis, D. Roselyn, Michael G. Nichols, Shakeel A. Khan, and Takanari Miyamoto. "Localization of the Platelet‐Activating Factor Receptor on the Intact Human Periodontal Ligament." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb24.

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Our laboratory has reported the presence of the lysophosphatidic acid receptor subtypes (LPARs) LPA1 and LPA3 on the intact human periodontal ligament (huPDL) using an in situ technique we developed (Cerutis et al. 2016). PAF (platelet‐activating factor) is another lipid mediator that also plays key homeostatic and inflammatory roles. Like LPA, it acts at nM concentrations and is found in significantly higher concentrations in saliva and gingival crevicular fluid from patients with chronic periodontal disease (PD), as we have reported for LPA (Bathena et al. 2011). It is now established that m

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Delage, A. "Lysophosphatidylcholine 16:0, a Promising Biomarker for Severe Fibromyalgia." Douleur et Analgésie, 2021. http://dx.doi.org/10.3166/dea-2021-0169.

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Fibromyalgia (FM) is a complex disease without any clear physiopathology, thus treating FM remains challenging for physicians. In this article Hung et al. propose a new mouse model of FM in which adult mice are exposed to repeated and intermittent sound stress (RISS). These stressors are shown to have an effect at the cellular level: leucocytes generate a high amount of reactive oxygen species (ROS), which triggers plasma lipid peroxidation and an excessive production of lysophosphatidylcholine (LPC) 16:0. LPC16:0 molecules then activate acid-sensing ion channel 3 (ASIC3) on muscle nociceptors

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