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1

Ould, Mohamed Yeslem Ahmed El Mouna, Cheibetta Moussa Ould, Abdelmajid Choukri, Jilali Ghassoun, Oum Keltoum Hakam, and Slimane Semghouli. "Preliminary Results of Quality Control for Linear Accelerator at Oncology Center in Nouakchott." British Journal of Medicine & Medical Research 22, no. 2 (2017): 1–8. https://doi.org/10.9734/BJMMR/2017/33918.

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The National Center of Oncology in Nouakchott is equipped with a linear accelerator which provides two energies in photon regime 6 MV and 18 MV. The basic dosimetric data required for quality of operation, in the clinical routine of the accelerator for photon beams are percentage depth dose (PDD) curves and beam profile (BP) curves. The aim of this work is to measure the percentage depth dose (PDD) and beam/dose profile (BP) for 6 MV and 18 MV photon beams for different field sizes and for different Skin-Source-Distance (SSD), and to compare the measured results with the results calculated by
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Singh, Avtar, Amit Saini, Rajesh A. Kinhikar, and Pankaj Kumar. "Initial Beam Characteristics Calculations of 6 MV FF X-Ray Beam from Elekta Versa-HD Linac Using Topas MC Simulation Code." ECS Transactions 107, no. 1 (2022): 6485–93. http://dx.doi.org/10.1149/10701.6485ecst.

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The focus of this research was to calculate initial beam characteristics of a 6 MV X-rays with flattening filter (FF) from Elekta Versa-HD linear accelerator (Linac) using the Tool for Particle Simulation (TOPAS) Monte Carlo (MC) simulation code. TOPAS 3.6 simulated data was compared with the measured data. During simulation, all the main component were simulated including Linac head, Multi-Leaf Collimators (MLCs), and uniform water phantom, while the SNC 3D scanner phantom and SNC125c Chamber were used for measurements. At collimator sizes of 5x5, 10x10, and 20x20 cm2, the depth dose scans (P
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Yu, Yongxiang, Zheng Zhang, Yingeng Wang, et al. "Complete Genome Sequence ofPhotobacterium damselaeSubsp.damselaeStrain SSPD1601 Isolated from Deep-Sea Cage-CulturedSebastes schlegeliiwith Septic Skin Ulcer." International Journal of Genomics 2019 (April 10, 2019): 1–7. http://dx.doi.org/10.1155/2019/4242653.

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Photobacterium damselaesubsp.damselae(PDD) is a Gram-negative bacterium that can infect a variety of aquatic organisms and humans. Based on an epidemiological investigation conducted over the past 3 years, PDD is one of the most important pathogens causing septic skin ulcer in deep-sea cage-culturedSebastes schlegeliiin the Huang-Bohai Sea area and present throughout the year with high abundance. To further understand the pathogenicity of this species, the pathogenic properties and genome of PDD strain SSPD1601 were analyzed. The results revealed that PDD strain SSPD1601 is a rod-shaped cell w
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Punge, H. J., H. Gallée, M. Kageyama, and G. Krinner. "Modelling snow accumulation on Greenland in Eemian, glacial inception, and modern climates in a GCM." Climate of the Past 8, no. 6 (2012): 1801–19. http://dx.doi.org/10.5194/cp-8-1801-2012.

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Abstract. Changing climate conditions on Greenland influence the snow accumulation rate and surface mass balance (SMB) on the ice sheet and, ultimately, its shape. This can in turn affect local climate via orography and albedo variations and, potentially, remote areas via changes in ocean circulation triggered by melt water or calving from the ice sheet. Examining these interactions in the IPSL global model requires improving the representation of snow at the ice sheet surface. In this paper, we present a new snow scheme implemented in LMDZ, the atmospheric component of the IPSL coupled model.
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Punge, H. J., H. Gallée, M. Kageyama, and G. Krinner. "Modelling snow accumulation on Greenland in Eemian, glacial inception and modern climates in a GCM." Climate of the Past Discussions 8, no. 2 (2012): 1523–65. http://dx.doi.org/10.5194/cpd-8-1523-2012.

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Abstract. Changing climate conditions on Greenland influence the snow accumulation rate and surface mass balance (SMB) on the ice sheet and, ultimately, its shape. This can in turn affect local climate via orography and albedo variations and, potentially, remote areas via changes in ocean circulation triggered by melt water or calving from the ice sheet. Examining these issues in the IPSL global model requires improving the representation of snow at the ice sheet surface. In this paper, we present the new snow scheme implemented in LMDZ, the atmospheric component of the IPSL coupled model. We
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Joshi, Smita Suhas, Steven Brad Maron, S. Lomnicki, et al. "Personalized antibodies for gastroesophageal adenocarcinoma (PANGEA): A phase II precision medicine trial (NCT02213289)." Journal of Clinical Oncology 36, no. 4_suppl (2018): TPS198. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.tps198.

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TPS198 Background: Targeted therapies (tx) in GEA have had limited efficacy despite recognition of numerous ‘targetable’ molecular events. This may be due to the molecular heterogeneity (MH) that exists between patients (pts), within the primary tumor (PT), between PT and synchronous metastatic lesions (MLs), and in lesions over time. Current biomarker profiling (BP) is performed on one site, usually the PT, yet this fails to capture the MH of GEA, with likely major clinical implications. Classic trial designs are challenged by MH, low frequency oncogenic drivers, and scarcity of tissue. There
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Catenacci, Daniel V. T., Bryan Peterson, Leah Chase, et al. "Personalized antibodies for gastroesophageal adenocarcinoma (PANGEA): Secondary and final primary efficacy analyses." Journal of Clinical Oncology 38, no. 15_suppl (2020): 4561. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4561.

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4561 Background: Targeted therapies (tx) have had limited benefit in advanced (aGEA) due to baseline spatial (primary vs metastatic tumor PT/MT) & temporal molecular heterogeneity (BMH/TMH). We previously reported PANGEA methods & results: 35% BMH rate & 10 OS results achieving 1yr OS of 66% & mOS of 16.4 months (m) using the personalized tx strategy (Catenacci et al. GI ASCO 2020 Abstr356). Here we will report the TMH rates at progressive disease points (PD1 & PD2), ORR/PFS/DCR in each of 3 tx lines, time to strategy failure (TTF), & updated OS/safety. Methods: PANGEA
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Catenacci, Daniel V. T., Samantha Lomnicki, Leah Chase, et al. "Personalized ANtibodies for GastroEsophageal Adenocarcinoma (PANGEA): Primary efficacy analysis of the phase II platform trial (NCT02213289)." Journal of Clinical Oncology 38, no. 4_suppl (2020): 356. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.356.

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356 Background: 1-yr OS is ~40% for HER2- & ~55% for HER2+ advanced (aGEA). Targeted therapies (tx) have had limited benefit due to molecular heterogeneity. Methods: This phase 2a study of a personalized tx strategy (PTS) enrolled newly diagnosed aGEA pts who then received up to 3 cytotoxic (cx) lines: first line (1L) 5FU + oxaliplatin, 2L 5FU + irinotecan & 3L 5FU + docetaxel. Baseline biomarker profiling (BP) was mandated on primary & metastatic tumors (PT/MT) & progressive disease points (PD1, PD2). Assigned antibody (AN) was added to cx by a predefined prioritized tx algori
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Popovych, Igor, Nataliya Kozyavkina, Liliya Barylyak, et al. "Variants of changes in blood pressure during its three consecutive registrations." Journal of Education, Health and Sport 12, no. 4 (2022): 365–75. http://dx.doi.org/10.12775/jehs.2022.12.04.032.

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Introduction and aim. Earlier we noted that the patterns of blood pressure (BP) parameters recorded three times in a row deserve special attention. The aim of this article is to classify variants of changes in systolic and diastolic BP during its three consecutive registrations. Material and methods. The object of observation were 20 volunteers: ten women and ten men aged 33-76 years with maladaptation. Systolic (Ps) and diastolic (Pd) BP was measured in a sitting position three times in a row without pause. Each patient was tested twice with a 7-day interval. Results. We confirmed the diversi
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Levin, Michael G., Derek Klarin, Venexia M. Walker, et al. "Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 6 (2021): 2027–34. http://dx.doi.org/10.1161/atvbaha.120.315482.

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Objective: We aimed to estimate the effect of blood pressure (BP) traits and BP-lowering medications (via genetic proxies) on peripheral artery disease. Approach and Results: Genome-wide association studies summary statistics were obtained for BP, peripheral artery disease (PAD), and coronary artery disease. Causal effects of BP on PAD were estimated by 2-sample Mendelian randomization using a range of pleiotropy-robust methods. Increased systolic BP (SBP), diastolic BP, mean arterial pressure (MAP), and pulse pressure each significantly increased risk of PAD (SBP odds ratio [OR], 1.20 [1.16–1
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Qin, Lu, Jian Cui, and Jianhua Li. "Sympathetic Nerve Activity and Blood Pressure Response to Exercise in Peripheral Artery Disease: From Molecular Mechanisms, Human Studies, to Intervention Strategy Development." International Journal of Molecular Sciences 23, no. 18 (2022): 10622. http://dx.doi.org/10.3390/ijms231810622.

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Sympathetic nerve activity (SNA) regulates the contraction of vascular smooth muscle and leads to a change in arterial blood pressure (BP). It was observed that SNA, vascular contractility, and BP are heightened in patients with peripheral artery disease (PAD) during exercise. The exercise pressor reflex (EPR), a neural mechanism responsible for BP response to activation of muscle afferent nerve, is a determinant of the exaggerated exercise-induced BP rise in PAD. Based on recent results obtained from a series of studies in PAD patients and a rat model of PAD, this review will shed light on SN
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Barthelmebs, Lise, Bruno Lecomte, Charles Divies, and Jean-François Cavin. "Inducible Metabolism of Phenolic Acids inPediococcus pentosaceus Is Encoded by an Autoregulated Operon Which Involves a New Class of Negative Transcriptional Regulator." Journal of Bacteriology 182, no. 23 (2000): 6724–31. http://dx.doi.org/10.1128/jb.182.23.6724-6731.2000.

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ABSTRACT Pediococcus pentosaceus displays a substrate-inducible phenolic acid decarboxylase (PAD) activity on p-coumaric acid. Based on DNA sequence homologies between the three PADs previously cloned, a DNA probe of the Lactobacillus plantarum pdc gene was used to screen a P. pentosaceus genomic library in order to clone the corresponding gene of this bacteria. One clone detected with this probe displayed a low PAD activity. Subcloning of this plasmid insertion allowed us to determine the part of the insert which contains a 534-bp open reading frame (ORF) coding for a 178-amino-acid protein p
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Kotidis, Charalampos, David Wertheim, Michael Weindling, Heike Rabe, and Mark A. Turner. "Assessing patent ductus arteriosus in preterm infants from standard neonatal intensive care monitoring." European Journal of Pediatrics 181, no. 3 (2021): 1117–24. http://dx.doi.org/10.1007/s00431-021-04311-9.

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AbstractMonitoring patent ductus arteriosus (PDA) in premature infants is currently performed intermittently using echocardiography which requires considerable expertise. The aim of this pilot study was to investigate whether PDA status could be assessed from standard neonatal intensive care monitoring. Electrocardiography (ECG) and blood pressure (BP) waveforms were acquired from extremely preterm infants using standard neonatal monitors. We developed software using MATLAB to analyse ECG and BP waveforms and their interrelationships in terms of pulse transit time (PTT) and pulse wave velocity
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穆, 宇灵. "Construction and Identification of Eukaryotic Expression Vector of Human Programmed Death Receptor 1." Bioprocess 08, no. 03 (2018): 55–60. http://dx.doi.org/10.12677/bp.2018.83007.

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15

Cavin, Jean-François, Véronique Dartois, and Charles Diviès. "Gene Cloning, Transcriptional Analysis, Purification, and Characterization of Phenolic Acid Decarboxylase from Bacillus subtilis." Applied and Environmental Microbiology 64, no. 4 (1998): 1466–71. http://dx.doi.org/10.1128/aem.64.4.1466-1471.1998.

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ABSTRACT Bacillus subtilis displays a substrate-inducible decarboxylating activity with the following three phenolic acids: ferulic, p-coumaric, and caffeic acids. Based on DNA sequence homologies between the Bacillus pumilus ferulate decarboxylase gene (fdc) (A. Zago, G. Degrassi, and C. V. Bruschi, Appl. Environ. Microbiol. 61:4484–4486, 1995) and theLactobacillus plantarum p-coumarate decarboxylase gene (pdc) (J.-F. Cavin, L. Barthelmebs, and C. Diviès, Appl. Environ. Microbiol. 63:1939–1944, 1997), a DNA probe of about 300 nucleotides for the L. plantarum pdcgene was used to screen a B. s
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O'Shaughnessy, Michelle M., Martin Durcan, Sinead M. Kinsella, Matthew D. Griffin, Donal N. Reddan, and David W. Lappin. "Blood Pressure Measurement in Peritoneal Dialysis: Which Method is Best?" Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 33, no. 5 (2013): 544–51. http://dx.doi.org/10.3747/pdi.2012.00027.

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BackgroundThe optimal approach to monitoring blood pressure (BP) in the peritoneal dialysis (PD) population is unclear. Ambulatory BP monitoring reliably predicts prognosis, but can be inconvenient. The accuracy of home BP monitoring in this population is unproven. The automated BpTRU device (BpTRU Medical Devices, Coquitlam, BC, Canada), which provides an average of up to 6 successive in-office BP measurements, has not been studied in this patient group.MethodsWe studied 17 patients (average age: 54 ± 12 years; 12 men, 5 women; 94% on automated PD) attending a single center. All patients unde
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Miller, Amanda J., J. Carter Luck, Danielle Jin-Kwang Kim, et al. "Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease." Journal of Applied Physiology 123, no. 5 (2017): 1160–65. http://dx.doi.org/10.1152/japplphysiol.00431.2017.

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The purpose of this study was to investigate blood pressure (BP) and leg skeletal muscle oxygen saturation (Smo2) during treadmill walking in patients with peripheral artery disease (PAD) and healthy subjects. Eight PAD patients (66 ± 8 yr, 1 woman) and eight healthy subjects (65 ± 7 yr, 1 woman) walked on a treadmill at 2 mph (0.89 m/s). The incline increased by 2% every 2 min, from 0 to 15% or until maximal discomfort. BP was measured every 2 min with an auscultatory cuff. Heart rate (HR) was recorded continuously with an ECG. Smo2 in the gastrocnemius muscle was measured on each leg using n
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Shinotoh, Hitoshi, Hitoshi Shimada, Yasumasa Kokubo, et al. "Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula." Neurology 92, no. 2 (2018): e136-e147. http://dx.doi.org/10.1212/wnl.0000000000006736.

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ObjectiveTo characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11C]PBB3 as ligand.MethodsThis is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [11C]PBB3, a
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Nguyen, Tuan, Ryan Ferguson, Victoria Wu, et al. "Pertussis toxin-dependent inhibition of trafficking receptors on plasmacytoid dendritic cells and delay in the polarization of Th17 cells expressing mucosal-associated trafficking receptors during B. pertussis infection. (P3031)." Journal of Immunology 190, no. 1_Supplement (2013): 55.16. http://dx.doi.org/10.4049/jimmunol.190.supp.55.16.

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Abstract Via murine infection models of B. pertussis (Bp) and BpΔPTX (Bp strain devoid of pertussis toxin [PTX]), we tested the hypothesis that PTX inhibits the expression of G-protein coupled receptors (GPCR) on dendritic cells (DC) and of mucosal-associated trafficking receptors (MATR) on CD4+ effector memory T cells. Lung plasmacytoid DC (pDC) increased during early infection with both strains. However, a reduced percentage of pDC from Bp infected lung expressed co-stimulatory molecules and the GPCR required for migration to secondary lymph nodes. Additionally, a modest rise of circulating
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Hwang, Jyh-Chang, Wei-Chih Kan, and Charn-Ting Wang. "High Water Evaporation Rate is Associated with Low Blood Pressure in Chronic Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 31, no. 1 (2011): 48–52. http://dx.doi.org/10.3747/pdi.2009.00164.

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BackgroundThe relationship between water evaporation rate (WER) and blood pressure (BP) in continuous ambulatory peritoneal dialysis (CAPD) patients has not been addressed before. This study was undertaken to evaluate the effects of WER on the BP and body weight (BW) of end-stage renal disease patients treated with CAPD.MethodsBased on mean WER of each month, the year 2005 was divided into “high WER” and “low WER” stages. This study enrolled 66 CAPD patients at our center during 2005. The BP and BW of each patient were collected monthly. WER was measured with a class A evaporation pan.ResultsC
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Correia, Marilia de Almeida, Aluísio Andrade-Lima, Antônio Henrique Germano-Soares, Gabriel Grizzo Cucato, Eduardo Caldas Costa, and Raphael Mendes Ritti-Dias. "AORTIC POST-RESISTANCE EXERCISE HYPOTENSION IN PATIENTS WITH PERIPHERAL ARTERY DISEASE." Revista Brasileira de Medicina do Esporte 24, no. 1 (2018): 17–19. http://dx.doi.org/10.1590/1517-869220182401162482.

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ABSTRACT Introduction: A single session of resistance training decreases brachial blood pressure (BP) in patients with peripheral artery disease (PAD). However, it is not known whether similar responses occur in aortic BP, which is a better predictor of cardiovascular risk. Objective: This study aimed to analyze the effects of a single session of resistance training on aortic BP in PAD patients. Methods: This randomized, crossover, controlled trial involved 16 patients. All of them performed a session of resistance training (R - 3 x 10 reps in eight exercises, 5-7 on the OMNI Scale) and a cont
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Shimauchi, Tsukasa, Takuro Numaga-Tomita, Yuri Kato, et al. "A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia." Cells 11, no. 13 (2022): 2041. http://dx.doi.org/10.3390/cells11132041.

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Retarded revascularization after progressive occlusion of large conductance arteries is a major cause of bad prognosis for peripheral artery disease (PAD). However, pharmacological treatment for PAD is still limited. We previously reported that suppression of transient receptor potential canonical (TRPC) 6 channel activity in vascular smooth muscle cells (VSMCs) facilitates VSMC differentiation without affecting proliferation and migration. In this study, we found that 1-benzilpiperadine derivative (1-BP), a selective inhibitor for TRPC3 and TRPC6 channel activities, induced VSMC differentiati
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Janus, Justyna, Jennifer K. Nicholls, Edward Pallett, Matthew Bown, and Emma M. L. Chung. "Are portable ankle brachial pressure index measurement devices suitable for hypertension screening?" PLOS ONE 18, no. 3 (2023): e0283281. http://dx.doi.org/10.1371/journal.pone.0283281.

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Objective In a large-scale population cardiovascular screening programme, peripheral artery disease (PAD) and hypertension would ideally be rapidly assessed using a single device. The ankle-brachial pressure index (ABPI) is calculated by comparing the ankle and brachial blood pressure (BP). However, it is currently unclear whether brachial BP measurements provided by automated PAD screening systems are sufficiently accurate for simultaneous hypertension screening. Methods Two portable PAD screening devices, the MESI ABPI MD and Huntleigh’s Dopplex ABIlity, were evaluated following the European
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Rutkowski, Bolesław, Paul Tam, Frank M. van der Sande, et al. "Residual Renal Function and Effect of Low-Sodium Solution on Blood Pressure in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 39, no. 4 (2019): 335–43. http://dx.doi.org/10.3747/pdi.2018.00120.

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BackgroundResidual renal function (RRF) affects sodium and fluid balance. The aim of this analysis was to examine the impact of RRF on the effect of a sodium-reduced peritoneal dialysis fluid (PDF) on blood pressure (BP).MethodsThis is a post-hoc analysis of a prospective, randomized, controlled double-blind clinical trial with 82 patients on continuous ambulatory PD (CAPD) treated with a low-sodium (125 mmol/L Na) or a standard-sodium (134 mmol/L Na) PDF. Subgroups according to glomerular filtration rate (GFR) at baseline (≤ / > 6 mL/min/1.73 m2) were analyzed for BP and antihypertensive m
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Nandiyanto, Asep Bayu Dani, Risti Ragadhita, Meli Fiandini, Dwi Fitria Al Husaeni, Dwi Novia Al Husaeni, and Farid Fadhillah. "Domestic waste (eggshells and banana peels particles) as sustainable and renewable resources for improving resin-based brakepad performance: Bibliometric literature review, techno-economic analysis, dual-sized reinforcing experiments, to comparison ..." Communications in Science and Technology 7, no. 1 (2022): 50–61. http://dx.doi.org/10.21924/cst.7.1.2022.757.

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The objective of this study is to develop a new environmentally-friendly brake pad made from eggshells (Es) and banana peels (BPs) as reinforcement agents. E and BP particles as dual reinforcement with various compositions were combined. The E/BP mixture was then embedded on a polymer matrix composing a resin/hardener mixture in a 1:1 ratio. As a standard, brake pads using a single reinforcement of E and BP particles were also fabricated. Physical properties (i.e. particle size, surface roughness, morphology, and density), as well as mechanical properties (i.e. hardness, wear rate, and frictio
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Lew, Susie Q., Neal Sikka, Clinton Thompson, Teena Cherian, and Manya Magnus. "Adoption of Telehealth: Remote Biometric Monitoring among Peritoneal Dialysis Patients in the United States." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 37, no. 5 (2017): 576–78. http://dx.doi.org/10.3747/pdi.2016.00272.

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We examined participant uptake and utilization of remote monitoring devices, and the relationship between remote biometric monitoring (RBM) of weight (Wt) and blood pressure (BP) with self-monitoring requirements. Participants on peritoneal dialysis (PD) (n = 269) participated in a Telehealth pilot study of which 253 used remote monitoring of BP and 255 for Wt. Blood pressure and Wt readings were transmitted in real time to a Telehealth call center, which were then forwarded to the PD nurses for real-time review. Uptake of RBM was substantial, with 89.7% accepting RBM, generating 74,266 BP and
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Miller, Amanda J., J. Carter Luck, Danielle Jin-Kwang Kim, et al. "Peripheral revascularization attenuates the exercise pressor reflex and increases coronary exercise hyperemia in peripheral arterial disease." Journal of Applied Physiology 125, no. 1 (2018): 58–63. http://dx.doi.org/10.1152/japplphysiol.01046.2017.

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Peripheral arterial disease (PAD) is associated with augmented blood pressure (BP) and impaired coronary blood flow responses to exercise, which may increase cardiovascular risk. We investigated the effects of leg revascularization on the BP and coronary blood flow responses to exercise in PAD. Seventeen PAD patients (11 men, 66 ± 2 yr) performed single-leg plantar flexion exercise 24 h before and 1 mo following leg revascularization. BP and heart rate (HR) were measured continuously, and rate pressure product (systolic BP × HR) was calculated as an index of myocardial oxygen demand. Coronary
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Luck, J. Carter, Amanda J. Miller, Faisal Aziz, et al. "Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease." Journal of Applied Physiology 123, no. 1 (2017): 2–10. http://dx.doi.org/10.1152/japplphysiol.01110.2016.

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Peripheral artery disease (PAD) is an atherosclerotic vascular disease that affects 200 million people worldwide. Although PAD primarily affects large arteries, it is also associated with microvascular dysfunction, an exaggerated blood pressure (BP) response to exercise, and high cardiovascular mortality. We hypothesized that fatiguing plantar flexion exercise that evokes claudication elicits a greater reduction in skeletal muscle oxygenation (SmO2) and a higher rise in BP in PAD compared with age-matched healthy subjects, but low-intensity steady-state plantar flexion elicits similar response
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Afshinnia, Farsad, Ziad S. Zaky, Manasa Metireddy, and Jonathan H. Segal. "Reverse Epidemiology of Blood Pressure in Peritoneal Dialysis Associated with Dynamic Deterioration of Left Ventricular Function." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 36, no. 2 (2016): 154–62. http://dx.doi.org/10.3747/pdi.2014.00264.

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BackgroundReverse epidemiology of blood pressure (BP) in end-stage kidney disease (ESKD) is manifested as higher mortality at lower blood pressure. We hypothesize that this phenomenon is partially mediated by deterioration of cardiac structure and function.MethodsSeventy-seven prevalent ESKD patients starting renal replacement therapy on peritoneal dialysis (PD) from 2007 to 2012 were evaluated for the primary outcome of all-cause mortality. Longitudinal data were obtained from 1,930 patient-encounters including monthly clinic BP and serial echocardiograms. Generalized linear mixed models usin
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Lin, L., H. Londe, CV Hanson, et al. "Photochemical inactivation of cell-associated human immunodeficiency virus in platelet concentrates." Blood 82, no. 1 (1993): 292–97. http://dx.doi.org/10.1182/blood.v82.1.292.bloodjournal821292.

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Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8- methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated proviral sequences are required. We have assessed the ability of the PCD technique to inactivate cell-associated human immunodeficiency virus 1 (HIV-1) in platelet concentrates. We correlated PCD inhibition of HIV-1 infectivity with 8-MOP-DNA adduct formation in contaminating nucle
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Restrepo, César, Jose Chacon, and Gilberto Manjarres. "Fungal Peritonitis in Peritoneal Dialysis Patients: Successful Prophylaxis with Fluconazole, as Demonstrated by Prospective Randomized Control Trial." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 30, no. 6 (2010): 619–25. http://dx.doi.org/10.3747/pdi.2008.00189.

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ObjectivesTo determine whether oral administration of the antifungal fluconazole during the entire period of treatment of bacterial peritonitis (BP), exit-site infection (ESI), or tunnel infection (TI) prevents later appearance of fungal peritonitis (called secondary) in patients with chronic kidney disease stage 5 in a peritoneal dialysis (PD) program.Patients and MethodsAll patients treated in the PD program in RTS Ltda Sucursal Caldas, during the period 1 June 2004 to 30 October 2007 were screened. Patients that had infectious bacterial complications (BP, ESI, TI) were included in a prospec
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Yeh, Chi-Hsiao, Hsiu-Chin Yu, Tzu-Yen Huang, et al. "High Systolic and Diastolic Blood Pressure Variability Is Correlated with the Occurrence of Peripheral Arterial Disease in the First Decade following a Diagnosis of Type 2 Diabetes Mellitus: A New Biomarker from Old Measurement." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9872945.

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Background. To assess whether the visit-to-visit variability in blood pressure (BP) is a risk factor of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM) 10 years after diagnosis. Methods. The electronic medical records of 825 patients, who were diagnosed with type 2 diabetes mellitus (T2DM) during 2000–2002 and regularly followed for 10 years, were retrospectively reviewed. A total of 53,284 clinic visit records, including analysis of BP, BMI, serum glycohemoglobin, and lipid profile, were analyzed. Results. Patients were categorized into two groups according
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Philippi, Alecco, and Reem Al-Rawi. "Comparing The Effects of Plant-Based Diets and Western Diets on Cardiovascular Disease Risk Factors: A Review." Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal 7, no. 7 (2023): 1–8. http://dx.doi.org/10.26685/urncst.488.

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Introduction: Dietary interventions are modifiable risk factors for cardiovascular diseases (CVDs). In particular, the plant-based diet (PBD), characterized by a higher intake of plant-based foods, has been associated with lower CVD risk. In contrast, the western diet (WD), containing higher intakes of processed and animal products, has been associated with increased CVD risk. This review compares the effects of PBDs and WDs on CVD risk factors including blood pressure (BP), low-density lipoprotein (LDL), and triglycerides. Methods: A database search was performed in PubMed and Embase (search
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Yang, Xiaoyan, Dongya Wang, Jiawei Zhu, et al. "Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy." Chemical Science 10, no. 13 (2019): 3779–85. http://dx.doi.org/10.1039/c8sc04844d.

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Bin-Nun, Alona, Yair Kasirer, Francis Mimouni, Irina Schorrs, Daniel Fink, and Cathy Hammerman. "Wide Pulse Pressure Is Not Associated with Patent Ductus Arteriosus in the First Week of Life." American Journal of Perinatology 36, no. 13 (2019): 1401–4. http://dx.doi.org/10.1055/s-0038-1677475.

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Objectives Widened pulse pressure is generally associated with patent ductus arteriosus (PDA). Surprisingly, this is often not true for preterm infants during the first week of life when systolic and diastolic pressures are both reduced and pulse pressure may remain unchanged. Study Design This is a retrospective, observational review of individual blood pressure (BP) parameters preterm neonates <30 weeks' gestational age during the first week of life as correlated with ductal patency and severity. Results Sixteen preterm neonates had a closed ductus on initial echocardiogram during the fir
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Herbreteau, Guillaume, Audrey Vallée, Anne-Chantal Knol, et al. "Circulating Tumor DNA Early Kinetics Predict Response of Metastatic Melanoma to Anti-PD1 Immunotherapy: Validation Study." Cancers 13, no. 8 (2021): 1826. http://dx.doi.org/10.3390/cancers13081826.

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The ability of early (first weeks of treatment) ctDNA kinetics to identify primary resistance to anti-PD1 immunotherapies was evaluated with a validation cohort of 49 patients treated with anti-PD1 for metastatic BRAF or NRAS-mutated melanoma, alone and pooled with the 53 patients from a previously described derivation cohort. BRAF or NRAS mutations were quantified on plasma DNA by digital PCR at baseline and after two or four weeks of treatment. ctDNA kinetics were interpreted according to pre-established biological response criteria. A biological progression (bP, i.e., a significant increase
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Park, Song-Young, Alexei Wong, Won-Mok Son, and Elizabeth J. Pekas. "Effects of heated water-based versus land-based exercise training on vascular function in individuals with peripheral artery disease." Journal of Applied Physiology 128, no. 3 (2020): 565–75. http://dx.doi.org/10.1152/japplphysiol.00744.2019.

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Peripheral artery disease (PAD) is an atherosclerotic disease that is associated with poor vascular function, walking impairment, and reduced quality of life. Land-based exercise therapy (LBET) is frequently recommended to improve walking and reduce symptoms. Recently, evidence has suggested that heated-water exercise therapy (HWET) is an effective intervention for PAD. However, the efficacy of LBET versus HWET in PAD patients had not been elucidated. Therefore, we sought to compare effects of LBET with HWET on cardiovascular function, exercise tolerance, physical function, and body compositio
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Xu, Hong, Ivan Cabezas-Rodriguez, Abdul Rashid Qureshi, et al. "Increased Levels of Modified Advanced Oxidation Protein Products are Associated with Central and Peripheral Blood Pressure in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 35, no. 4 (2015): 460–70. http://dx.doi.org/10.3747/pdi.2013.00064.

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♦Background and Aims Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Central blood pressure (BP) is thought to be more relevant than peripheral BP for the pathogenesis of CVD. Advanced oxidation protein products (AOPP) are markers of oxidative stress. This study investigated the relationship between AOPP and central BP in peritoneal dialysis (PD) patients. ♦Methods In a cross-sectional study of 75 PD patients (67% men), we analyzed two oxidative stress markers, AOPP (modified assay, mAOPP, correcting for the impact of triglycerides) and pentosidine
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Chen, Jian Guo, and Zhao Guang Li. "Application of Support Vector Machine in Springback Forecasting for Steel Structure." Applied Mechanics and Materials 166-169 (May 2012): 1366–69. http://dx.doi.org/10.4028/www.scientific.net/amm.166-169.1366.

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Support vector machine is applied to springback forecasting for steel structure in the paper. In the steel structure, pressure-pad-force, friction coefficient and die filleted corner have a certain influence on springback amount.We employ BP neural network to compare with support vector machine to show the superiority of support vector machine in this study. Finally,we give the comparison of the prediction error of springback for steel structure between support vector machine and BP neural network. Evidently,the springback prediction for steel structure of support vector machine is better than
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Del Pinto, Rita, Leandra Serio, Elena Campanozzi, et al. "CARDIOMETABOLIC RISK FACTORS AND LIFESTYLE HABITS IN THE GENERAL POPULATION: RESULTS OF AN AWARENESS-RAISING EDUCATIONAL CAMPAIGN FOR HEALTH EMPOWERMENT." Journal of Hypertension 42, Suppl 1 (2024): e167. http://dx.doi.org/10.1097/01.hjh.0001021060.61915.f3.

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Objective: Most individuals have little awareness of their health status and do not engage in prevention measures to reduce the risk of future cardiovascular diseases (CVD. We conducted an observational study to assess the prevalence of common cardiometabolic risk factors and modifiable lifestyle measures in the general population. Design and method: During an awareness-raising educational campaign for cardiovascular prevention (October 10th, 2023), a cross-sectional study on consecutive volunteer individuals was conducted. Participants self-presented at local sites and accepted to undergo sta
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Murai, Yasuo, Eitaro Ishisaka, Atsushi Tsukiyama, et al. "Reuse of a Reversed “Bone Pad” to Perforate Incompletely Penetrated Burr Holes Created by Automatic-Releasing Cranial Perforators." Operative Neurosurgery 13, no. 3 (2017): 324–28. http://dx.doi.org/10.1093/ons/opw043.

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Abstract BACKGROUND: It can be difficult to make complete burr holes using a perforator with automatic releasing systems in cases of a soft diploe or thick calvarial bone. OBJECTIVE: To demonstrate the utility of a flipped “bone pad” (BP) in recovery of penetration failure when using an automatic releasing perforator. METHODS: For craniotomy or ventricular drainage, the first step is to make 1 or more burr holes using a craniotome. Neurosurgeons sometimes incompletely penetrate the skull using the latest tools. As a countermeasure for such cases, we have developed a simple and practical method
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Zahra, Rusyda, Syukriy Abdullah, Adnan Adnan, and Fifi Yusmita. "PENGARUH PENDAPATAN ASLI DAERAH DAN ASET TETAP TERHADAP BELANJA PEMELIHARAAN: SEBUAH BUKTI EMPIRIS DARI PEMERINTAH DAERAH DI INDONESIA DI MASA PANDEMI COVID-19." Jurnal Ilmiah Mahasiswa Ekonomi Akuntansi 8, no. 2 (2023): 224–33. http://dx.doi.org/10.24815/jimeka.v8i2.24413.

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The purpose of this study is to provide empirical evidence of the effect of Local Own Revenue (PAD) and Fixed Assets (AT) on Maintenance Expenditure (BP) at local governments in Indonesia during the Covid-19 pandemic using a multiple linear regression model. The data used is secondary data sourced from the audited local government financial statements (fiscal year 2020) of 215 local governments as the sample. We used the purposive sampling method. The sample criteria are local governments experiencing a deficit in 2019 and obtaining an unqualified opinion (WTP) in 2020. The results showed that
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Sorescu Marinkovic, Annemarie. "Ivana Pantelić, Uspon i pad „prve drugarice“ Jugoslavije: Jovanka Broz i srpska javnost 1952-2013. [The Rise and Fall of Yugoslavia’s “First Female Comrade”: Jovanka Broz and the Serbian Public, 1952-2013]. Beograd: Službeni glasnik, 2018, 337 pp." Balcanica Posnaniensia. Acta et studia 26 (December 3, 2019): 300–302. http://dx.doi.org/10.14746/bp.2019.26.19.

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Crouch, Joe. "Small island, ‘big swamp’, Kuiku Pad Reef: Sarbi 4200–3500 cal BP, western Torres Strait." Quaternary International 385 (October 2015): 88–101. http://dx.doi.org/10.1016/j.quaint.2015.02.011.

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Chakrabarty, Mousumi, and Bonti Bora. "The measurement of blood pressure in winter season and its co-relation with blood pressure after cold exposure in summer season: a cross-sectional study in Gauhati medical college and hospital, Guwahati, Assam, India." International Journal of Research in Medical Sciences 5, no. 7 (2017): 3111. http://dx.doi.org/10.18203/2320-6012.ijrms20172997.

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Background: The aim of the study was to correlate the change in blood pressure in winter season to that in summer season after exposure to localized cold stimuli.Methods: Basal blood pressure in healthy males of 20-40 years was recorded during winter season by conventional method using sphygmomanometer and stethoscope. During summer, the same subjects were taken and their baseline blood pressure was recorded. Thereafter their feet were immersed in cold water at 12 degree centigrade and blood pressure was recorded at 5 minutes and 10 minutes interval. The systolic and diastolic BP during winter
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Anfoka, G., F. Haj Ahmad, M. Altaleb, et al. "First Report of Recombinant Potato virus Y Strains Infecting Potato in Jordan." Plant Disease 98, no. 7 (2014): 1017. http://dx.doi.org/10.1094/pdis-03-14-0236-pdn.

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Potato (Solanum tuberosum L.) is an important vegetable crop in Jordan, occupying second position after olives. In 2012, potatoes were planted on about 6,000 ha with a production of about 141,000 t (2). Potato virus Y (PVY) is a serious problem for potato production worldwide. Recombinant strains of the virus were reported to cause tuber necrotic ringspot disease (PTNRD) in many potato-growing regions of the world. In the last few years, a new recombinant PVYNTN-NW that belongs to PVYZ (3) has been reported in the neighboring Syria. It included three recombination patterns, SYR-I, SYR-II, and
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Gardner, Andrew W., Polly S. Montgomery, Ming Wang, Chixiang Chen, Marcos Kuroki, and Danielle Jin-Kwang Kim. "Greater Exercise Pressor Response Is Associated With Impaired Claudication Outcomes in Symptomatic Peripheral Artery Disease." Angiology 70, no. 3 (2018): 220–28. http://dx.doi.org/10.1177/0003319718790876.

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We determined whether a greater exercise pressor response during a constant-load treadmill test was associated with lower peak walking time (PWT) and claudication onset time (COT) measured during a graded maximal treadmill test in 304 patients with symptomatic peripheral artery disease (PAD). The exercise pressor response was assessed by measuring heart rate and blood pressure (BP) at rest and during a constant-load treadmill test (speed = 2 mph, grade = 0%). After only 2 minutes of walking, mean heart rate increased by 26 beats/min from rest and mean systolic BP increased by 16 mm Hg. In adju
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Roszkowska-Blaim, Maria, and Piotr Skrzypczyk. "Risk Factors for Decline of Residual Renal Function in Children Treated with Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 36, no. 6 (2016): 669–75. http://dx.doi.org/10.3747/pdi.2014.00123.

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Background The aim of the study was to assess risk factors for residual renal function (RRF) decline in children during the first/second year of chronic peritoneal dialysis (PD). Methods The study group included 56 children with end-stage renal disease (ESRD) (age 10.13 ± 4.86 years), including 18 on continuous ambulatory PD (CAPD) and 38 on automated PD (APD), in whom we evaluated RRF (daily diuresis [mL/m2/24 h], residual glomerular filtration rate (rGFR) [mL/min/1.73 m2]), etiology of ESRD, PD fluid volume (mL/m2/24 h), glucose load (g/m2/24 h), ultrafiltration (mL/m2/24 h), peritoneal perm
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Meng, J. R., P. P. Liu, C. W. Zou, et al. "First Report of a Tospovirus in Mulberry." Plant Disease 97, no. 7 (2013): 1001. http://dx.doi.org/10.1094/pdis-08-12-0792-pdn.

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Mulberry (Morus alba L.) is an economically important crop grown widely throughout Asia. Various virus-like symptoms including mosaics, vein banding, and chlorotic ringspots have been observed and reported on mulberry trees in China and Japan for decades. However, the etiology of mulberry viral diseases is generally understudied, although two mulberry-infecting viruses, Mulberry latent virus (genus Carlavirus) (2) and Mulberry ringspot virus (genus Nepovirus) (3), have been partially characterized. In a recent (2010 to 2011) field survey in Guangxi Province, China, supported by the local gover
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Zhu, Bi Yun, Lan Gao, and Hao Ming Li. "Monascus anka Pyruvate Decarboxylase Accounts for the New Candidate Resources of Fuel Ethanol Production." Advanced Materials Research 512-515 (May 2012): 432–38. http://dx.doi.org/10.4028/www.scientific.net/amr.512-515.432.

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In order to study the nature and function of Pyruvate decarboxylase (PDC, E.C.4.1.1.1), which is the key enzyme to produce ethanol by fermentation; full-length cDNA library was constructed with SMART technique from Monascus anka CICC 5031. The pdc gene, including a 1713-bp open reading frame, encoding a 570 amino acid protein, was obtained by screening the constructed M. anka cDNA library. The pdc gene was successfully heterologously expressed in E.coli BL21(DE3), accounting for 32.7% of total cellular proteins. Recombinant PDC was expressed in prokaryotic cells and purified by affinity chroma
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