Journal articles: 'Peau pathologie'

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Fitoussi, C. "Pathologie d’adaptation de la peau noire en France métropolitaine." Annales de Dermatologie et de Vénéréologie 133, no. 11 (November 2006): 871–75. http://dx.doi.org/10.1016/s0151-9638(06)71064-x.

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Sans, N., C. Lalande, M. N. Assouère, O. Loustau, M. L. Despeyroux-Ewers, and J. J. Railhac. "A3 Anatomie de la peau en IRM : aspects normaux et premieres applications en pathologie." Journal de Radiologie 85, no. 9 (September 2004): 1473. http://dx.doi.org/10.1016/s0221-0363(04)77537-x.

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Häusermann. "Hauterscheinungen bei Nierenkrankheiten." Praxis 91, no. 24 (June 1, 2002): 1063–70. http://dx.doi.org/10.1024/0369-8394.91.24.1063.

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Les manifestations cutanées en cas de maladies des reins sont souvent spécifiques et peuvent ainsi, lors d'une analyse approfondie du tégument, signaler une pathologie des organes internes. A part un certain nombre de syndromes héréditaires et de maladies liées à des symptômes cutanés et rénaux, des anomalies de la peau spécifiques et non spécifiques sont principalement mentionnées en cas d'une insuffisance rénale chronique. Par rapport à une représentation détaillée des possibilités thérapeutiques, la priorité est accordée à la description macroscopique et microscopique des anomalies de la peau et aux mécanismes pathophysiologiques.

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Faye, Bernard, M. Ratovonanahary, and Renaud Cherrier. "Effet d'un facteur alimentaire sur la pathologie néonatale : Résultats d'une enquête rétrospective sur la distribution de mangrove aux chamelons en République de Djibouti." Revue d’élevage et de médecine vétérinaire des pays tropicaux 46, no. 3 (March 1, 1993): 471–78. http://dx.doi.org/10.19182/remvt.9449.

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Une enquête rétrospective réalisée dans 23 campements de nomades afars de la région d'Obock (Djibouti) a porté sur les modes d'utilisation traditionnelle de la végétation lagunaire (mangrove à palétuviers) et leur relation avec la pathologie observée, notamment chez les chamelons. Quatre types d'exploitation de la mangrove peuvent être décrits : distribution de branches de palétuvier aux chamelons âgés de moins d'un an dans les campements et pâturage des adultes dans la mangrove; utilisation permanente de la mangrove associée à une complémentation; exploitation occasionnelle par émondage; utilisation permanente sans complémentation. Le risque d'observer des troubles sanitaires (pertes d'appétit, boiterie, paralysie, maladies de peau) est 4,28 fois plus élevé en l'absence de complémentation de la ration de base de mangrove.

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Epelboin, A. "Journée scientifique de la Société de pathologie exotique, Peau et maladies tropicales 21 novembre 2019, école du Val-de-Grâce, Paris." Bulletin de la société de pathologie exotique 112, no. 4 (October 28, 2019): 246–50. http://dx.doi.org/10.3166/bspe-2019-0100.

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Tan, Stephen, Kucy Pon, Joanne Bargman, and Danny Ghazarian. "Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease." Journal of Cutaneous Medicine and Surgery 7, no. 5 (September 2003): 390–94. http://dx.doi.org/10.1177/120347540300700505.

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Background: Cutis laxa is a heterogeneous group of inherited and acquired disorders characterized clinically by loose skin and histologically by altered elastic tissue. Heavy chain deposition disease is a very rare monoclonal immunoglobulin disorder, distinct from multiple myeloma, in which there is production and deposition of defective immunoglobulin heavy chains without light chain deposition. Objective: We describe a case of acquired cutis laxa associated with heavy chain deposition disease. Results: A 50-year-old male presented with acute renal failure, IgG4 heavy chain deposition in the kidneys, and no evidence of multiple myeloma. Four years later, he developed generalized acquired cutis laxa, emphysema, and a peripheral polyneuropathy. On pathology, there was destruction of elastic fibers within the dermis. Conclusion: This case describes a previously unreported association between acquired cutis laxa and heavy chain deposition disease. Antécédents: Cutis laxa est un groupe hétérogène de troubles héréditaires et acquis qui se caractérise cliniquement par un relâchement de la peau et histologiquement par l'altération du tissu élastique. La maladie des chaînes lourdes est un trouble très rare de l'immunoglobuline monoclonale, différent du myélome multiple où il y a production et dépôt de chaînes lourdes, sans chaînes légères, de l'immunoglobuline déficiente. Objectif: Description d'un cas non conventionnel de cutis laxa acquise associée à une maladie des chaînes légères. Méthodes: Description du cas et aperçu de cutis laxa. Observation: Un homme de 50 ans présente une insuffisance rénale, des dépêts dans les reins de chaînes lourdes IgG4 et aucune preuve de myélome multiple. Quatre ans plus tard, il développe une cutis laxa généralisée acquise, un emphysème et une Polyneuropathie périphérique. La pathologie a montré une destruction des fibres élastiques du derme. Conclusion: Ce cas décrit une association jamais établie auparavant entre cutis laxa et une maladie des chaînes lourdes.

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Pippione, M. "EPU6 - Les lésions élémentaires de la peau et corrélation clinico-pathologique." Annales de Dermatologie et de Vénéréologie 134, no. 1 (January 2007): 101–2. http://dx.doi.org/10.1016/s0151-9638(07)89173-3.

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Debroas, Guilhaume, Guillaume Hoeffel, Ana Reynders, and Sophie Ugolini. "Interactions neuro-immunes dans la peau." médecine/sciences 34, no. 5 (May 2018): 432–38. http://dx.doi.org/10.1051/medsci/20183405016.

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Lors d’une infection, notre capacité à éliminer les pathogènes dépend essentiellement de notre système immunitaire. Des études récentes révèlent cependant un rôle du système nerveux dans la régulation des processus infectieux et inflammatoires. Des interactions fonctionnelles bidirectionnelles s’établissent entre systèmes nerveux et immunitaire pour préserver l’intégrité des tissus. La peau constitue l’une des premières lignes de défense contre les menaces extérieures et présente un système neuro-immun particulièrement développé. En cas de lésion cutanée, des neurones impliqués dans la perception douloureuse sont activés et modulent la fonction et le recrutement des cellules immunitaires au sein du tissu. Nous illustrons ici l’importance de ces régulations neuro-immunes à travers différents exemples de pathologies cutanées.

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Mol, Merel O., Jeroen G. J. van Rooij, Esther Brusse, Annemieke J. M. H. Verkerk, Shamiram Melhem, Wilfred F. A. den Dunnen, Patrizia Rizzu, Chiara Cupidi, John C. van Swieten, and Laura Donker Kaat. "Clinical and pathologic phenotype of a large family with heterozygous STUB1 mutation." Neurology Genetics 6, no. 3 (March 23, 2020): e417. http://dx.doi.org/10.1212/nxg.0000000000000417.

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ObjectiveTo describe the clinical and pathologic features of a novel pedigree with heterozygous STUB1 mutation causing SCA48.MethodsWe report a large pedigree of Dutch decent. Clinical and pathologic data were reviewed, and genetic analyses (whole-exome sequencing, whole-genome sequencing, and linkage analysis) were performed on multiple family members.ResultsPatients presented with adult-onset gait disturbance (ataxia or parkinsonism), combined with prominent cognitive decline and behavioral changes. Whole-exome sequencing identified a novel heterozygous frameshift variant c.731_732delGC (p.C244Yfs*24) in STUB1 segregating with the disease. This variant was present in a linkage peak on chromosome 16p13.3. Neuropathologic examination of 3 cases revealed a consistent pattern of ubiquitin/p62-positive neuronal inclusions in the cerebellum, neocortex, and brainstem. In addition, tau pathology was present in 1 case.ConclusionsThis study confirms previous findings of heterozygous STUB1 mutations as the cause of SCA48 and highlights its prominent cognitive involvement, besides cerebellar ataxia and movement disorders as cardinal features. The presence of intranuclear inclusions is a pathologic hallmark of the disease. Future studies will provide more insight into its pathologic heterogeneity.

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Branthwaite, Helen, Gemma Grabtree, Nachiappan Chockalingam, and Andrew Greenhalgh. "The Effect of Toe Flexion Exercises on Grip." Journal of the American Podiatric Medical Association 108, no. 5 (September 1, 2018): 355–61. http://dx.doi.org/10.7547/16-167.

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Background: Weakness of the toe flexor muscles has been attributed to the development of toe pathologies, and it responds well in the clinic to toe grip exercises. However, it is unknown whether exercising the toe flexor muscles improves the ability to grip and alter function. The aim of this study was to assess the effect of toe flexor exercises on apical plantar pressure, as a measure of grip, while seated and during gait. Methods: Twenty-three individuals with no known toe pathologies were recruited. Static peak pressure, time spent at peak pressure, and pressure-time integral while seated, as well as dynamic forefoot maximal force, contact area, and percentage contact time, were recorded before and after exercise. Toe grip exercises with a therapy ball were completed daily for 6 weeks. Results: Static peak pressure significantly increased after exercise on the apex of the second and third digits, as did the pressure-time integral. Dynamic peak force and contact area did not alter after exercise around the metatarsals and toes, yet percentage contact time significantly increased for each metatarsal after completing daily toe grip exercises. Conclusions: Exercises to improve the grip ability of the toes increased the static peak pressure on the apex of the second and third digits as well as the percentage contact time of the metatarsals during gait. The ability to increase apical peak pressure and contact time after exercises could assist in improving forefoot stability and gait efficiency and in reducing toe pathology progression.

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Gosling, Sarah, Robert Scott, Charlene Greenwood, Pascaline Bouzy, Jayakrupakar Nallala, Iain D. Lyburn, Nicholas Stone, and Keith Rogers. "Calcification Microstructure Reflects Breast Tissue Microenvironment." Journal of Mammary Gland Biology and Neoplasia 24, no. 4 (December 2019): 333–42. http://dx.doi.org/10.1007/s10911-019-09441-3.

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AbstractMicrocalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcification microstructure is also found to differ between tissue pathologies, including differential ion substitutions and the presence of additional crystallographic phases. Distinguishing between tissue pathologies at an early stage is essential to improve patient experience and diagnostic accuracy, leading to better disease outcome. This study explores the hypothesis that microenvironment features may become immortalised within calcification crystallite characteristics thus becoming indicators of tissue pathology. In total, 55 breast calcifications incorporating 3 tissue pathologies (benign – B2, ductal carcinoma in-situ - B5a and invasive malignancy - B5b) from archive formalin-fixed paraffin-embedded core needle breast biopsies were analysed using X-ray diffraction. Crystallite size and strain were determined from 548 diffractograms using Williamson-Hall analysis. There was an increased crystallinity of hydroxyapatite with tissue malignancy compared to benign tissue. Coherence length was significantly correlated with pathology grade in all basis crystallographic directions (P < 0.01), with a greater difference between benign and in situ disease compared to in-situ disease and invasive malignancy. Crystallite size and non-uniform strain contributed to peak broadening in all three pathologies. Furthermore, crystallite size and non-uniform strain normal to the basal planes increased significantly with malignancy (P < 0.05). Our findings support the view that tissue microenvironments can influence differing formation mechanisms of hydroxyapatite through acidic precursors, leading to differential substitution of carbonate into the hydroxide and phosphate sites, causing significant changes in crystallite size and non-uniform strain.

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Mirmalek, Seyed Abbas, Maryam Hajilou, Seyed Alireza Salimi Tabatabaee, Yekta Parsa, Soheila Yadollah-Damavandi, and Tina Parsa. "Prevalence of HER-2 and Hormone Receptors and P53 Mutations in the Pathologic Specimens of Breast Cancer Patients." International Journal of Breast Cancer 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/564308.

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Prognostic factors are in interest for breast cancer as the second cause of malignancy deaths. Some have predictive values as human epidermal growth factor receptor-2 (HER-2) and estrogen receptor (ER). To access the incidence of HER2 and its relations to other factors, like age, pathology, ER, progesterone receptor (PR), and P53, 2000 pathologic blocks from 2750 total samples have been selected from 2011 to 2013 in Cancer Institute of Tehran. Incidence of HER2, ER, PR, and P53 was; 58.5%, 33.4%, 43.3%, and 65.4%, respectively. Invasive ductal carcinoma was the most pathologic type (82.2%) and 60%–70% positive HER2 and P53 had negative ER and PR (poor prognosis). The peak age of incidence of breast cancer was perimenopausal age group (46–55 years). Our cases had more positive HER2 and P53 and less positive PR and ER compared to other studies. High perimenopausal incidence as another finding assures the importance of breast cancer screening in these age groups.

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Bhugra, Parul. "Hysterectomy: retrospective analysis of 476 cases." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (April 28, 2020): 1930. http://dx.doi.org/10.18203/2320-1770.ijrcog20201782.

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Background: Diseases of the female genital tract are commonly encountered in clinical practice. Hysterectomy is the definite treatment for many of the pelvic pathologies. The present study is aimed at analysis of age and types of hysterectomy and evaluation of histopathological reports of the hysterectomy specimens.Methods: A total of 476 consecutive hysterectomy were studied over a period of two years from January 2016 to December 2017.Results: The peak age group of hysterectomy was 41-50 years with 221 (46.43%) cases. The commonest type of hysterectomy was abdominal. The most common endometrial pathology was atrophic endometrium, seen in 131 (27.52%) cases. In myometrium, the most common pathology was leiomyoma in 179 (37.61%) cases. Among cervical lesions, chronic cervicitis was the most common finding, seen in 274 (57.56%) cases.Conclusions: The experience with various types of hysterectomies at our institution has been reviewed. A wide spectrum of lesions were observed when histopathology reports of the hysterectomy specimens were analysed.

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Benavente Villegas, F. C., F. Alfageme Roldán, and D. Suárez Massa. "Peau d’Orange Appearance (Pseudocellulitis) and Elastography." Actas Dermo-Sifiliográficas (English Edition) 111, no. 7 (September 2020): 612. http://dx.doi.org/10.1016/j.adengl.2020.08.001.

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Mohassel, Payam, Océane Landon-Cardinal, A. Reghan Foley, Sandra Donkervoort, Katherine S. Pak, Colleen Wahl, Robert T. Shebert, et al. "Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy." Neurology - Neuroimmunology Neuroinflammation 6, no. 1 (December 12, 2018): e523. http://dx.doi.org/10.1212/nxi.0000000000000523.

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ObjectiveTo determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations.MethodsPatients with presumed LGMD and unrevealing genetic testing were selected based on a few clinico-pathologic features and tested for anti-HMGCR autoantibodies (n = 11). These clinico-pathologic features are peak creatine kinase (CK) greater than 1,000 IU/L and at least 3 of the following features: (1) limb-girdle pattern of weakness, (2) selective involvement of posterior thigh on clinical examination or muscle imaging, (3) dystrophic changes on muscle biopsy, and (4) no family history of muscular dystrophy.ResultsSix patients tested positive for anti-HMGCR autoantibodies. In 4, there was a presymptomatic phase, lasting as long as 10 years, characterized by elevated CK levels without weakness. Muscle biopsies revealed variable degrees of a dystrophic pathology without prominent inflammation. In an independent cohort of patients with anti-HMGCR myopathy, 17 of 51 (∼33%) patients were initially presumed to have a form of LGMD based on clinico-pathologic features but were ultimately found to have anti-HMGCR myopathy. Most of these patients responded favorably to immunomodulatory therapies, evidenced by reduction of CK levels and improved strength.ConclusionsAnti-HMGCR myopathy can resemble LGMD. Diagnosis of patients with a LGMD-like presentation of anti-HMGCR myopathy is critical because these patients may respond favorably to immunotherapy, especially those with shorter disease duration.

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Jandial, Roopali, Mehnaz Choudhary, and Kuldeep Singh. "Histopathological analysis of hysterectomy specimens in a tertiary care centre: study of 160 cases." International Surgery Journal 6, no. 8 (July 25, 2019): 2856. http://dx.doi.org/10.18203/2349-2902.isj20193330.

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Background: Hysterectomy is the most commonly performed gynaecological surgery as the female reproductive system has been affected by various non-neoplastic and neoplastic conditions during the life time of a woman.Methods: This retrospective study was conducted on 160 hysterectomy specimens reported to Department of Pathology. They were compared in terms of age of the patients and pathology of hysterectomy specimens. The histopathological findings of hysterectomy specimens was noted and these findings were then correlated with clinical diagnosis. The aim of the study was to evaluate the wide range of pathological lesions, commonest pathology involved and correlation of the preoperative clinical diagnosis with the histopathological diagnosis in the hysterectomy specimens.Results: The most common type of hysterectomy was total abdominal hysterectomy with bilateral salpingo-ophorectomy with 102 cases (63.7%). Peak incidence at 5th decade of life in 92 cases (57.5%) was noted. The most common clinical indication was fibroid uterus in 81 cases (50.6%). Proliferative phase of endometrium was the commonest finding in 87 cases (54.3%). In case of myometrium, 95 leiomyomas were noted. On histomorphological study of cervical lesions, chronic cervicitis was commonest finding in 75 (46.8%) cases.Conclusions: Few double pathologies can be missed clinically so clinico-pathological correlation in all cases of hysterectomy has been proved to be important to improve the clinical outcome and post-operative management.

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Conway, Katie A., Randall G. Bissette, and Jason R. Franz. "The Functional Utilization of Propulsive Capacity During Human Walking." Journal of Applied Biomechanics 34, no. 6 (December 1, 2018): 474–82. http://dx.doi.org/10.1123/jab.2017-0389.

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Aging and many gait pathologies are characterized by reduced propulsive forces and ankle moment and power generation during trailing leg push-off in walking. Despite those changes, we posit that many individuals retain an underutilized reserve for enhancing push-off intensity during walking that may be missed using conventional dynamometry. By using a maximum ramped impeding force protocol and maximum speed walking, we gained mechanistic insight into the factors that govern push-off intensity and the available capacity thereof during walking in young subjects. We discovered in part that young subjects walking at their preferred speed retain a reserve capacity for exerting larger propulsive forces of 49%, peak ankle power of 43%, and peak ankle moment of 22% during push-off—the latter overlooked by maximum isometric dynamometry. We also provide evidence that these reserve capacities are governed at least in part by the neuromechanical behavior of the plantarflexor muscles, at least with regard to ankle moment generation. We envision that a similar paradigm used to quantify propulsive reserves in older adults or people with gait pathology would empower the more discriminate and personalized prescription of gait interventions seeking to improve push-off intensity and thus walking performance.

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Stock, Nathalie. "Tumeurs conjonctives de la peau. Cas no 3. Neurothécome cellulaire." Annales de Pathologie 29, no. 5 (October 2009): 395–98. http://dx.doi.org/10.1016/j.annpat.2009.10.014.

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Vergier, Béatrice, Hugues Bégueret, and Vincent Orlandini. "Tumeurs conjonctives de la peau. Cas no 5. Léiomyosarcome desmoplastique." Annales de Pathologie 29, no. 5 (October 2009): 403–6. http://dx.doi.org/10.1016/j.annpat.2009.10.017.

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Schaub. "Hautveränderungen bei Lebererkrankungen." Praxis 91, no. 23 (June 1, 2002): 1037–41. http://dx.doi.org/10.1024/0369-8394.91.23.1037.

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Le foie est après la peau l'organe le plus grand de l'organisme. Il est bien connu qu'il existe plusieurs signes cutanés pour les maladies hépatiques. Il est vrai qu'il n'existe pas toujours de corrélation entre la sévérité de la maladie hépatique et les affections cutanées qui, en plus, ne sont pas toujours spécifiques. On peut observer plusieurs types d'interaction entre le foie et la peau: 1. Une maladie hépatique peut causer des signes cutanés. 2. La peau et le foie peuvent être atteints par le même processus pathologique. 3. Une maladie de peau peut être la cause d'une maladie hépatique. 4. Des médicaments pour traiter des affections cutanées peuvent nuire au foie. Par la suite, les deux premiers points seront discutés.

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McLean, Andrew J. "Peak and Trough." Medical Humanities 43, no. 1 (September 13, 2016): e4-e4. http://dx.doi.org/10.1136/medhum-2016-011043.

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Costa, Gino, and Rachel Neild. "Police Reform in Peru." Australian & New Zealand Journal of Criminology 38, no. 2 (August 2005): 216–29. http://dx.doi.org/10.1375/acri.38.2.216.

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Following a political transition, Peru launched a police reform in 2001. This study focuses on internal and external impediments to the reform. The highly transparent and democratic process won public support and the backing of rank-and-file officers, but failed to overcome opposition from police leadership. The strength of senior police opposition is directly related to financial interests threatened by anticorruption initiatives. In the external environment, government weakness and lack of presidential support present critical breaking points. Additional external weaknesses include the politically independent profile of the Interior Ministry reform team, the lack of a politically negotiated reform plan, and the absence of international backing. Presidential support failed at a critical moment when police challenged the Interior Minister. Noting the limitations of different evaluative criteria in policing reforms, the article argues that important advances have been achieved in policing in Peru even as short-term impacts are limited.

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Fraitag, Sylvie. "Tumeurs conjonctives de la peau. Cas no 1. Tumeur fibrohistiocytaire plexiforme." Annales de Pathologie 29, no. 5 (October 2009): 385–89. http://dx.doi.org/10.1016/j.annpat.2009.10.007.

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Guillou, Louis. "Tumeurs conjonctives de la peau. Cas no 7. Histiocytome fibreux atypique." Annales de Pathologie 29, no. 5 (October 2009): 411–15. http://dx.doi.org/10.1016/j.annpat.2009.10.009.

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Ortonne, Nicolas. "La peau, cible privilégiée des maladies auto-immunes, infectieuses et médicamenteuses." Annales de Pathologie 38, no. 1 (February 2018): 4–6. http://dx.doi.org/10.1016/j.annpat.2017.10.013.

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Ottaviano, G., V. Lund, E. Nardello, B. Scarpa, G. Frasson, A. Staffieri, and G. Scadding. "Comparison between unilateral PNIF and rhinomanometry in healthy and obstructed noses." Rhinology journal 52, no. 1 (March 1, 2014): 25–30. http://dx.doi.org/10.4193/rhino13.037.

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Aims: Peak Nasal Inspiratory Flow (PNIF) is an easy method to assess nasal patency. Normative unilateral PNIF data in adults have been proposed. The study purpose was to compare PNIF and unilateral PNIF values to total and unilateral nasal resistances measured by anterior active rhinomanometry (AAR) in subjects with and without nasal obstruction to see whether unilateral PNIFis sensitive to detect nasal obstruction. Methods and results: Measurements of PNIF, unilateral PNIF and AAR were performed in 125 volunteers. Seventy of them were healthy subjects not complaining of nasal symptoms and entered into the study as the'normal' group. The other group consisted of fifty-five symptomatic subjects.Data were analysed to show the correlation between PNIF, unilateral PNIF and nasal resistances. The ability of PNIF and AAR in predicting pathologies were compared by receiver operating characteristic (ROC) analysis indicating that PNIF and AAR have a similar and significant power to discriminate pathologic from healthy subjects. Conclusion: The measurement of unilateral PNIF could be a helpful method to support the diagnosis of nasal blockage also in those cases with single nostril obstruction, but, in cases of doubt, AAR should also be performed to improve diagnostic accuracy.

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Ferrari, Sara, Mitchell Silva, Vittorio Sala, Daniel Berckmans, and Marcella Guarino. "BIOACOUSTICS: A TOOL FOR DIAGNOSIS OF RESPIRATORY PATHOLOGIES IN PIG FARMS." Journal of Agricultural Engineering 40, no. 1 (March 31, 2009): 7. http://dx.doi.org/10.4081/jae.2009.1.7.

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Cough is the element for monitoring and diagnosis of respiratory disease cause of mortality and loss of productivity in pig houses. In order to prevent as much as possible the outbreak of such diseases the aim of this research is to describe acoustic features of cough sounds originating from infections due to Actinobacillosis and Pasteurellosis and to compare them with healthy cough sounds provoked by inhalation of citric acid. The acoustic parameters investigated are peak frequency [Hz] and duration of cough signals. The differences resulting from the cough sound analysis confirmed a variability in acoustics parameters according to a state of health or disease in the animals. Sound analysis provides physic acoustic features that can be used as tool to label and detect cough in a automatic monitoring system applied in farms.

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Coindre, Jean-Michel. "Tumeurs conjonctives de la peau. Cas no 6. Fibromyxome superficiel des extrémités." Annales de Pathologie 29, no. 5 (October 2009): 407–10. http://dx.doi.org/10.1016/j.annpat.2009.10.006.

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Fraitag, Sylvie. "Tumeurs conjonctives de la peau. Cas no 2. Fibroblastome à cellules géantes." Annales de Pathologie 29, no. 5 (October 2009): 390–94. http://dx.doi.org/10.1016/j.annpat.2009.10.008.

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Boulanger, Nathalie. "Rôle immunomodulateur de la salive de tique dans la transmission d’agents infectieux." Biologie Aujourd'hui 212, no. 3-4 (2018): 107–17. http://dx.doi.org/10.1051/jbio/2019001.

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Les tiques sont les vecteurs les plus importants de pathologies en médecine humaine et vétérinaire. Acariens strictement hématophages, ils produisent une salive riche en molécules bioactives qui ciblent la pharmacologie et l’immunité de l’hôte. Ce processus est absolument vital pour elles, car les tiques dures prennent des repas sanguins de plusieurs jours et doivent éviter leur rejet par l’hôte. Tous les acteurs de l’immunité sont ciblés par cette salive : l’immunité innée en lien avec les cellules résidentes de la peau et les cellules immunitaires et l’immunité adaptative liée aux lymphocytes T et B. La peau constitue donc un site particulier dans les maladies à transmission vectorielle. Au cours de leur longue co-évolution avec les tiques, les agents infectieux prennent avantage de cet environnement favorable pour être transmis efficacement dans la peau et se multiplier, pour ensuite se développer chez les hôtes vertébrés. La salive constitue pour ces microorganismes un véritable facteur de virulence qui augmente fortement leur pathogénicité.

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Arber, Daniel A., Lawrence M. Weiss, Pedro F. Albújar, Yuan-Yuan Chen, and Elaine S. Jaffe. "Nasal Lymphomas in Peru." American Journal of Surgical Pathology 17, no. 4 (April 1993): 392–99. http://dx.doi.org/10.1097/00000478-199304000-00010.

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Ferry, Judith A., and Nancy L. Harris. "Nasal Lymphomas in Peru." American Journal of Surgical Pathology 17, no. 11 (November 1993): 1194. http://dx.doi.org/10.1097/00000478-199311000-00017.

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Arber, Daniel A., Lawrence M. Weiss, and Elaine S. Jaffe. "Nasal Lymphomas in Peru." American Journal of Surgical Pathology 17, no. 11 (November 1993): 1195. http://dx.doi.org/10.1097/00000478-199311000-00018.

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Vergier, Béatrice. "Introduction. Tumeurs conjonctives de la peau : « Je regarde et je ne sais pas ! »." Annales de Pathologie 29, no. 5 (October 2009): 383–84. http://dx.doi.org/10.1016/j.annpat.2009.10.015.

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Vergier, Béatrice, and Laurent Tisseau. "Tumeurs conjonctives de la peau. Cas no 4. Prolifération vasculaire « atypique » après radiothérapie." Annales de Pathologie 29, no. 5 (October 2009): 399–402. http://dx.doi.org/10.1016/j.annpat.2009.10.016.

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Knesewitsch, P., N. H. Göldel, S. Fritsch, and E. Moser. "Beurteilung der Adriamycin-Kardiotoxizität mittels der Äquilibrium-Radionuklid-Ventrikulographie." Nuklearmedizin 26, no. 05 (1987): 206–11. http://dx.doi.org/10.1055/s-0038-1628890.

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Results of 606 equilibrium radionuclide ventriculographies (ERNV) performed in 348 non-selected patients receiving Adriamycin (ADM) therapy were stored in a data base system. The aim of the study was to assess the influence of a potential cardiotoxic therapy on left ventricular pump function. Increasing ADM doses yielded a significant (p <0.05) decrease of the resting ejection fraction (R-gEF), the peak ejection rate and the peak filling rate. Enddiastolic and endsystolic volumes increased significantly. Stroke volume, heart rate and time to peak filling rate did not change significantly. 368 follow-up studies were performed in 128 patients: 65/128 patients presented a decrease of R-gEF, but only in 45 of these patients R-gEF values fell into the pathologic range. In 44 of these follow-ups, R-gEF remained unchanged. In 19 patients, a R-gEF increase was observed. At the beginning of ADM therapy 14% of the patients had subnormal R-gEF values. With increasing ADM doses pathologic findings increased to 86% in patients with ADM doses higher than 500 mg/m2.

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Smith, Catherine, Simon K. Spooner, and John Alan Fletton. "The Effect of 5-Degree Valgus and Varus Rearfoot Wedging on Peak Hallux Dorsiflexion During Gait." Journal of the American Podiatric Medical Association 94, no. 6 (November 1, 2004): 558–64. http://dx.doi.org/10.7547/0940558.

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The dynamic effects of 5° varus and valgus rearfoot wedging on peak hallux dorsiflexion were investigated in 30 asymptomatic subjects (5 males and 25 females). Statistically significant reductions in peak hallux dorsiflexion were found with rearfoot varus wedging and rearfoot valgus wedging. Furthermore, the reduction in peak hallux dorsiflexion occurring with rearfoot varus wedging was statistically significant compared with that associated with rearfoot valgus wedging. These findings have implications for the orthotic management of a variety of lower-limb pathologies. (J Am Podiatr Med Assoc 94(6): 558–564, 2004)

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Brandler, Tamar C., Dana Warfield, Esther Adler, Aylin Simsir, Marie-Ange Exilhomme, Andre L. Moreira, Kristen Thomas, and Joan Cangiarella. "Lessons Learned From an Anatomic Pathology Department in a Large Academic Medical Center at the Epicenter of COVID-19." Academic Pathology 8 (January 1, 2021): 237428952199424. http://dx.doi.org/10.1177/2374289521994248.

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Many state-wide, city-wide, and hospital-wide changes have been implemented due to the ongoing COVID-19 crisis. We describe lessons learned in an anatomic pathology division at a tertiary care center during the peak of the COVID-19 pandemic in the hopes that knowledge of our experiences can benefit other pathology departments as they encounter this pandemic. Five categories that are critical in strategic planning for the COVID-19 pandemic are discussed: workload, departmental policy revisions, impact on faculty, workforce staffing, and impact on educational programs, including residency and fellowship training. Although the volume of COVID-19 testing had grown placing increased demands on the clinical pathology laboratory, the volume of anatomic pathology cases had declined during the COVID-19 peak. Lessons learned were widespread including changes in the anatomic pathology workflow due to declining surgical and cytologic case volumes and increases in autopsy requests. Modifications were required in gross room policies, levels of personal protective equipment, and workforce. Travel and meeting policies were impacted. Adaptations to residency and fellowship programs were vast and included innovations in didactic and interactive education. We must learn from our experiences thus far in order to move forward, and we hope that our experiences in an anatomic pathology department in the epicenter of the COVID-19 pandemic can help other pathology departments across the country.

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Rank, Roger G., Anne K. Bowlin, and Kathleen A. Kelly. "Characterization of Lymphocyte Response in the Female Genital Tract during Ascending Chlamydial Genital Infection in the Guinea Pig Model." Infection and Immunity 68, no. 9 (September 1, 2000): 5293–98. http://dx.doi.org/10.1128/iai.68.9.5293-5298.2000.

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ABSTRACT It is well known that pathology caused by chlamydial infection is associated closely with the host response to the organism and that both innate and adaptive host responses contribute to tissue damage. While it is likely that the organism itself initiates the acute inflammatory response by eliciting cytokine and chemokine production from the host cell, the adaptive response is the result of activation of the cell-mediated immune response. While there are several studies describing the nature of the pathologic response in primate, guinea pig, and murine models, there is less information on the kinetics of the CD4 and CD8 response following primary and challenge infections. In this study, we have quantified by flow cytometry the mononuclear cell response to genital infection with the agent of guinea pig inclusion conjunctivitis in the cervix, endometrium, and oviducts at various times following a primary intravaginal infection and after a challenge infection. Tissues from individual animals were assessed for cells expressing CD4, CD8, or Mac-1 and for B cells. Peak responses of each subset occurred 10 to 14 days after a primary infection. The number of Mac-1-expressing cells in each tissue site was found to be dependent on the size of the inoculating dose of chlamydiae. The responses of each cell type were generally stronger in the cervix than in the upper genital tract. In contrast to the murine model but consistent with the primate models, there were equal numbers of CD4 and CD8 cells present in the infiltrates. Twenty-one days after challenge infection, which was performed 50 days after the primary infection, there was a significant increase in the number of CD4, CD8, and B cells in the oviduct compared to the number of these cells at the same time after a primary infection, providing clear cellular evidence for a cell-mediated immune pathologic response.

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Pulici, Sergio, and Piergiorgio Schiavoni. "Role of Functional Indicators in the Multifactorial Pathologies in Cardiopulmonary Rehabilitatiion." Clinical & Investigative Medicine 30, no. 3 (June 1, 2007): 45. http://dx.doi.org/10.25011/cim.v30i3.1752.

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Background: Patients in cardiopulmonary rehabilitation often complain of exercise intolerance. While ventilatory limitation is often present, other factors are also important: cardiovascular deconditioning, respiratory muscle dysfunction, gas exchange abnormalities and ventricular dysfunction. Methods: Forty patients, hospitalized for a consecutive 6 month-period, with persistent exercise intolerance due to cardiopulmonary pathologies were included. 90% were COPD II to IV GOLD stage; 5% had chronic cardiac decompensation; 5% had undergone surgery for coronary bypass and/or cardiac valve prosthesis. Patients were excluded who were clinically unstable, unable to cooperate correctly, had arrythmia due to atrial fibrillation and/or receiving beta-blocking therapy. We have, furthermore, measured parameters of ventilatory dysfunction (ventilatory reserve, dynamic inspiratory capacity), the parameters of cardiovascular limitation (peak heart rate and recovery heart rate at the first minute), parametes of respiratory muscles dysfunction (maximal inspiratory pressure and at the end of the 6 min walking test). Afterwards we classified patients into three groups: ventilatory-limited, cardiovascular-limited, respiratory muscles-limited. Results: Exercise performance limitation resulted from ventilatory limitation in 60% of the patients, second by cardiovascular limitation in 30% of the patients and also by respiratory muscle limitation in 10% of the patients. Conclusions: Based on admission diagnosis of 40 patients, 90% were defined as subject to pulmonary rehabilitation and in 10% were receiving cardiac rehabilitation. They divided into three specific functional recovery programs: ventilatory function recovery program (60%), cardiac function recovery program (30%), respiratory muscles recovery program (10%).

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Bensefa-Colas, Lynda, Nathalie Nourry, Emilie Pepin, Serge Brunel, Lynda Larabi, Natalie Vongmany, Isabelle Vanrullen, Juliette Bloch, and Dominique Dupas. "Cancers primitifs de la peau hors mélanome et expositions professionnelles : données du Réseau national de vigilance et de prévention des pathologies professionnelles (RNV3P) 2001–2016." Archives des Maladies Professionnelles et de l'Environnement 79, no. 3 (May 2018): 436. http://dx.doi.org/10.1016/j.admp.2018.03.512.

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Hogan, S. L., P. H. Nachman, A. S. Wilkman, J. C. Jennette, and R. J. Falk. "Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis." Journal of the American Society of Nephrology 7, no. 1 (January 1996): 23–32. http://dx.doi.org/10.1681/asn.v7123.

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The purpose of this study was to determine the prognostic value of clinical, laboratory, and pathologic features at the time of presentation on patient and renal survival in patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated microscopic polyangiitis and glomerulonephritis (excluding Wegener's granulomatosis). One hundred seven ANCA-positive patients with necrotizing and crescentic glomerulonephritis, including 69 with evidence for microscopic polyangiitis, were evaluated for this study. The relative risk of death was calculated for the following potential prognostic indicators: (1) ANCA pattern; (2) pulmonary hemorrhage at onset; (3) presence of extrarenal manifestations versus renal limited disease; and (4) treatment with corticosteroids and cyclophosphamide (intravenous or oral), compared with corticosteroids alone. Cox's proportional hazard model was used to assess the predictive value of the following variables on renal survival: (1) age; (2) race; (3) pulmonary symptoms at onset of disease; (4) renal pathology; (5) ANCA pattern; and (6) peak serum creatinine values obtained near the time of renal biopsy. Patients were followed prospectively for 2.5 yr (range, 5 days to 12 yr 2 months). There were 12 disease-related deaths and 46 patients who reached ESRD. The relative risk (and 95% confidence interval) of patient death was 8.65 (3.36, 22.2) times greater in patients who presented with pulmonary hemorrhage, and 3.78 (1.22, 11.70) times greater in patients with cytoplasmic ANCA compared to those with perinuclear ANCA. The relative risk of pulmonary hemorrhage was no different by ANCA pattern. The risk of death was 5.56 times lower in the cyclophosphamide-treated patients versus those treated with corticosteroids alone. The predictors of renal survival were entry serum creatinine value (P = 0.0002), race (African Americans having a worse outcome compared with Caucasians, P = 0.0008), and the presence of arterial sclerosis on kidney biopsy (P = 0.0076) when controlling for age, ANCA pattern, microscopic polyangiitis versus glomerulonephritis alone, and pulmonary involvement. Pathology indices such as glomerular necrosis, glomerular crescents, glomerular sclerosis, and interstitial sclerosis were not predictive of renal survival when controlling for entry serum creatinine value, race, and arterial sclerosis. However, in the subgroup of patients with a peak creatinine value of < or = 3.0 mg/dL (N = 29), increased interstitial sclerosis was a predictor of a poor renal outcome (P = 0.04).

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Dahlstrom, Jane E. "Performing at your peak: internal clinical audit." Pathology 45 (2013): S3. http://dx.doi.org/10.1097/01.pat.0000426740.94400.27.

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Algu, Tameshwar K. "A case of concomitant intussusception and appendicitis managed at a regional hospital in Guyana." Tropical Doctor 50, no. 4 (July 20, 2020): 385–87. http://dx.doi.org/10.1177/0049475520940479.

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Appendicitis and intussusception are two potentially fatal surgical pathologies occurring at different peak age groups. Simultaneous presentation of both is rare. We present such a case in an eight-month-old infant who required successful emergency laparotomy with right hemicolectomy and primary anastomosis. Appendicitis was confirmed histologically.

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Guillou, Louis. "Tumeurs conjonctives de la peau. Cas no 8. Hémangiome acquis en touffes (angioblastome de Nakagawa)." Annales de Pathologie 29, no. 5 (October 2009): 416–19. http://dx.doi.org/10.1016/j.annpat.2009.10.010.

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46

Azar, Sasha, Shannan Rossi, Sherry Haller, Ruimei Yun, Jing Huang, Jessica Plante, Jiehua Zhou, et al. "ZIKV Demonstrates Minimal Pathologic Effects and Mosquito Infectivity in Viremic Cynomolgus Macaques." Viruses 10, no. 11 (November 21, 2018): 661. http://dx.doi.org/10.3390/v10110661.

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To evaluate the effects of ZIKV infection on non-human primates (NHPs), as well as to investigate whether these NHPs develop sufficient viremia to infect the major urban vector mosquito, Aedes aegypti, four cynomolgus macaques (Macaca fascicularis) were subcutaneously infected with 5.0 log10 focus-forming units (FFU) of DNA clone-derived ZIKV strain FSS13025 (Asian lineage, Cambodia, 2010). Following infection, the animals were sampled (blood, urine, tears, and saliva), underwent daily health monitoring, and were exposed to Ae. aegypti at specified time points. All four animals developed viremia, which peaked 3–4 days post-infection at a maximum value of 6.9 log10 genome copies/mL. No virus was detected in urine, tears, or saliva. Infection by ZIKV caused minimal overt disease: serum biochemistry and CBC values largely fell within the normal ranges, and cytokine elevations were minimal. Strikingly, the minimally colonized population of Ae. aegypti exposed to viremic animals demonstrated a maximum infection rate of 26% during peak viremia, with two of the four macaques failing to infect a single mosquito at any time point. These data indicate that cynomolgus macaques may be an effective model for ZIKV infection of humans and highlights the relative refractoriness of Ae. aegypti for ZIKV infection at the levels of viremia observed.

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Glazer, Evan Scott, Omar Maen Rashid, Pamela Joy Hodul, Jose Mario Pimiento, and Mokenge Peter Malafa. "Association of decreased peak SUV on PET after neoadjvuant therapy in patients with borderline resectable pancreatic carcinoma with pathologic response." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 423. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.423.

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423 Background: Despite the use of PET scan in metastatic staging, its utility as a biomarker for borderline resectable pancreatic carcinoma (BRPC) is unclear. The peak standardized uptake value (SUVpeak) is the average SUV around the most avid portion of the tumor. We hypothesized that tumor pathologic response (PR) to neoadjuvant therapy will correlate with SUVpeak changes after therapy. Methods: We reviewed our database of patients with BRPC who completed neoadjuvant chemotherapy (GTX) followed by radiation and had pre- and post- neoadjuvant PET scans. Changes in the SUVpeak were calculated by subtracting the post-neoadjuvant/pre-resection PET scan from the pre-neoadjuvant PET scan. PET responders were defined as those patients whose SUVpeak decreased by 4 units (the overall average decrease in SUVpeak) or more. Results: We identified 74 patients- 32 patients developed progressive disease and 42 patients underwent surgery. The average age was 66 ± 9 years; 61% of patients were male. On the final pathologic specimens, 5 patients had a complete PR to therapy while 23 patients had a moderate PR (1-49% viable tumor) and 14 patients had a minimal PR (≥ 50% viable tumor). PR is associated with a decrease in SUVpeak (p = 0.02; Table). The area under the receiver operator characteristic curve for changes in SUVpeakand complete PR was 0.83 ± 0.08. Of the PET responders who underwent surgery, 29% had a complete PR while none of the PET non-responders had a complete PR (p = 0.004). Of the unresected patients, PET responders had a longer overall survival compared to non-responders (18 ± 7 vs. 12 ± 7 months, p < 0.05). Nodal disease was not associated with PR (p > 0.3). Conclusions: PR was significantly associated with a decrease in SUVpeak post-neoadjuvant therapy in patients with BRPC. Even in patients with unresectable disease, SUVpeak provides useful prognostic data. We believe that pre- and post-neoadjuvant therapy PET scans may be used as a prognostic biomarker in patients with BRPC. [Table: see text]

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Matsumori, Yoichi, Maki Aizawa, Yoshiko Sakai, Daisuke Inoue, Michiko Kodani, Osamu Tsuha, Akira Beppu, et al. "Congenital abnormalities in calves associated with Peaton virus infection in Japan." Journal of Veterinary Diagnostic Investigation 30, no. 6 (September 11, 2018): 855–61. http://dx.doi.org/10.1177/1040638718796269.

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Peaton virus (PEAV; family Peribunyaviridae, genus Orthobunyavirus) appears to be capable of producing congenital malformations in ruminants; however, its pathogenicity remains unknown given its relatively low incidence. We evaluated the relationship between congenital abnormalities of calves and PEAV infection by serologic, epidemiologic, pathologic, and virologic investigations using specimens from 31 malformed calves in the years 1996–2016 in Japan. Antibody testing was carried out for known teratogenic viruses, including Akabane, Aino, Chuzan, and bovine viral diarrhea viruses, in the precolostral sera of these abnormal calves, but all results were negative. However, all 31 malformed calves were positive for antibodies against PEAV. A PEAV-specific gene was amplified from central nervous system tissues from a stillborn calf delivered in April 2007, and its nucleotide sequence was identical with that of PEAV isolated from healthy sentinel cattle in September 2006. These findings indicate that PEAV can cause bovine congenital anomalies.

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Tkachenko, L. V. "Analysis of liver pathologies in stray dogs in the age aspect (sectional study)." E3S Web of Conferences 254 (2021): 08027. http://dx.doi.org/10.1051/e3sconf/202125408027.

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The presence of stray animals in megacities or small settlements is the result of human activity. Stray dogs are in direct contact with representatives of wild fauna, influencing the occurrence and spread of various epizootics and epidemics. Stray animals, as a part of society, can serve as a biological model for understanding the influence of the environment on the body. We conducted a sectional study of 32 dogs aged from 2 years to 10 years and older. As a result, it was found that there is no correlation between sex and liver pathologies. Liver pathologies in stray animals were observed in the period from 2 to 7 years old, with a peak at 6 years of age, by 8 years old the number of pathologies decreases almost 2–3 times. Liver cirrhosis (45%), protein dystrophy of the liver (45%), acute congestive hyperemia of the liver (19%), fatty liver dystrophy (16%) and neoplasms in the liver (13%) were recorded as often as possible in stray animals. The main causes of liver pathologies in stray animals were: stress, toxic effects of food or chemicals (poisoning), pathogens of infectious diseases, metabolic disorders, internal bleeding (car injury).

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SINCLAIR, JONATHAN, CHRIS EDMUNDSON, STEPHEN ATKINS, PAUL JOHN TAYLOR, and HAYLEY VINCENT. "The effect of front and back squat techniques on peak loads experienced by the Achilles tendon." Baltic Journal of Health and Physical Activity 7, no. 3 (September 30, 2015): 7–12. http://dx.doi.org/10.29359/bjhpa.07.3.01.

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Background: A primary technique in the discipline of strength and conditioning the squat has two principal ‘back and front’ variants. Despite the physiological and strength benefits of the squat, the propensity for musculoskeletal injury is high. The current investigation examined the influence of the front and back squat variations on the load experienced by the Achilles tendon. Material/Methods: Achilles tendon loads were obtained from eighteen experienced male participants as they completed both back and front squats. Differences between squat conditions were examined using Bonferroni adjusted (p = 0.0125) paired t-tests. Results: The results showed that the peak Achilles tendon load was significantly greater in the back squat (2.67 ±0.74 B.W) condition compared to the front squat (2.37 ±0.69 B.W). Conclusions: Given the proposed relationship between the magnitude of the load experienced by the Achilles tendon and tendon pathology, the back squat appears to place lifters at greater risk from Achilles tendon injury. Therefore, it may be prudent for lifters who are predisposed to Achilles tendon pathology to utilize the front squat in their training.

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Journal articles on the topic 'Peau pathologie'

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