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Relevant bibliographies by topics / Penicillin biosynthesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Penicillin biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Smith, David John. "A genetic study of penicillin biosynthesis in Penicillium chrysogenum." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292440.

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2

Long, Alexandra. "Structural studies on penicillin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393574.

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3

Porter, Michael James. "Mechanistic investigations into penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308806.

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4

Rowe, Christine Janet. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307008.

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5

Sutherland, John David. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253132.

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6

Martyres, Dominic H. "Bicyclic penicillin mimics." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365770.

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7

Shorrock, Celia Patricia. "Studies on penicillin and cephalosporin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298666.

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8

Killin, S. J. "Studies on the biosynthesis of penicillin." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379964.

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9

Domayne-Hayman, B. P. "Penicillin biosynthesis : Mechanistic probes containing small rings." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379884.

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10

Moroney, S. E. "Kinetic studies on the biosynthesis of penicillin." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354849.

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11

Morgan, Nicholas. "Genetic engineering of cephalosporin biosynthesis." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239322.

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12

Fleming, Mark Daniel. "Studies on the 6-APA:acyl-coenzyme A acyltransferase from Penicillium chrysogenum and Aspergillus nidulans." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291515.

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13

Orford, Colin David. "The enzymes and intermediates involved in the early stages of #beta#-lactam antibiotic biosynthesis in Penicillium chrysogenum." Thesis, University of Westminster, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252655.

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14

Pizzinini, Enrica. "Role of the sulphate assimilation pathway in penicillin biosynthesis." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246945.

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15

Harper, J. "Studies on the genetic regulation of penicillin biosynthesis in filamentous fungi." Thesis, University of Sheffield, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284769.

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16

Riach, Maureen B. R. "Molecular and classical genetic analysis of penicillin biosynthesis in Aspergillus nidulans." Thesis, University of St Andrews, 1994. http://hdl.handle.net/10023/14263.

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Clones of A. nidulans genomic DNA (pSTA200, pSTA201 and pSTA207) spanning 20 kb have been isolated and demonstrated by a combination of classical and molecular genetic means to represent the npeA locus, involved in the synthesis of penicillin, located on linkage group VI of A. nidulans. As well as containing, the gene encoding the second enzyme for penicillin biosynthesis, namely isopenicillin N synthetase (IPNS) (designated ipnA), results presented here show that these clones contain two additional genes to form a cluster of three contiguous penicillin biosynthetic genes. Our evidence suggest

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17

Busch, Silke. "Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans." Doctoral thesis, [S.l.] : [s.n.], 2002. http://hdl.handle.net/11858/00-1735-0000-0006-AE62-6.

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18

Taylor, Helen. "The penicillin binding proteins and autolysins of Streptomyces coelicolor and their putative roles in resistance to Î² lactam antibiotics." Thesis, Liverpool John Moores University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288224.

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19

Robinson, N. G. "New amino acid syntheses : Applications to studies on penicillin biosynthesis and C-nucleoside synthesis." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375322.

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20

Marquess, Daniel. "Studies on the insertion-homolysis mechanism for carbon-sulphur bond formation in penicillin biosynthesis." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306548.

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21

Smith, Gary Thomas. "Inhibition of IPNS." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276831.

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22

Arezi, Bahram. "Mutational analysis of ACV synthetase in fungi." Thesis, University of Sheffield, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265916.

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23

Challis, Gregory Leonard. "Studies on the biosynthesis of antimicrobial natural products." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390494.

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24

Tobin, Matthew B. "Genetic engineering of the acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239249.

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25

Thulin, Elisabeth. "Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330856.

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The introduction of antibiotics in healthcare is one of the most important medical achievements with regard to reducing human morbidity and mortality. However, bacterial pathogens have acquired antibiotic resistance at an increasing rate, and due to a high prevalence of resistance to some antibiotics they can no longer be used therapeutically. The antibiotic mecillinam, which inhibits the penicillin-binding protein PBP2, however, is an exception since mecillinam resistance (MecR) prevalence has remained low. This is particularly interesting since laboratory experiments have shown that bacteria

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26

Siddique, Muhammad Hussnain. "Study of the biosynthesis pathway of the geosmin in Penicillium expansum." Thesis, Toulouse, INPT, 2012. http://www.theses.fr/2012INPT0085/document.

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La géosmine est un terpénoïde, provoquant un goût moisi-terreux associée à des flaveurs atypiques dans l'eau et le vin. Chez les bactéries, la voie de biosynthèse de la géosmine est bien caractérisée, mais peu de connaissance sont disponibles au sujet de sa biosynthèse chez les eucaryotes, en particulier dans les champignons filamenteux. L'origine de la géosmine dans la vigne est en grande partie attribuable à la présence de Penicillium expansum sur les raisins. Dans cette thèse, afin de mieux comprendre la voie de biosynthèse de la géosmine chez Penicillium expansum, nous avons décrit la cara

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27

Gaudet, Veroniuque Suzanne. "Synthetic and enzymatic studies related to the biosynthesis of penicillic acid and acetoin." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/102292/.

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The stereochemistry of the loss of one enantiotopic C-2 hydrogen atom of malonyl-coenzyme A units during the transformations leading to pencillic acid was undertaken. Aspartic acid stereospecifically deuterated at C-3 via the formation of N-benzyl aspartic acid was attempted. The addition of benzylamine in 2H20 or dioxan across the double bond of maleic or fumaric acids was revealed to be non stereospecific and these results have been tentatively explained. (2S,3R)-[32H1]- and (2S,3S)-(2,3-2H2)-aspartic acids were derivatized to the corresponding deuterated diethyl N-p-toluenesulfonyl aspartat

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28

Fan, Jie [Verfasser], and Shu-Ming [Akademischer Betreuer] Li. "Biosynthesis of penilactones and peniphenones in Penicillium crustosum / Jie Fan ; Betreuer: Shu-Ming Li." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1209269198/34.

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29

Snini, Selma. "Élucidation de la voie de biosynthèse d’une mycotoxine, la patuline : caractérisation du cluster de gène et étude de la régulation." Thesis, Toulouse, INPT, 2014. http://www.theses.fr/2014INPT0103/document.

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Penicillium expansum est un contaminant commun des pomaceae (pommes et poires) causant la pourriture bleue. Ce champignon est le principal responsable de la présence de patuline dans les pommes et ses produits dérivés. Actuellement, la voie de biosynthèse de la patuline n’est que partiellement élucidée et le cluster de gènes correspondant n’est décrit que chez Aspergillus clavatus, champignon tellurique incapable de se développer dans les pommes. La caractérisation moléculaire de la voie de biosynthèse de la patuline est la condition sine qua none à toute étude visant à comprendre la régulatio

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30

El, Hajj Assaf Christelle. "Patulin, main mycotoxin of the apple industry : regulation of its biosynthetic pathway and influence of processing factors in cloudy apple juice production." Thesis, Toulouse, INPT, 2018. http://www.theses.fr/2018INPT0148/document.

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Parmi les maladies affectant les pommes, la moisissure bleue causée par Penicillium expansum est une préoccupation majeure. Elle cause des pertes de rendement et de qualité dues également à la production de mycotoxines telles que la patuline (PAT) et la citrinine (CIT). La PAT est la plus alarmante en raison de ses propriétés cytotoxiques, génotoxiques et immunosuppressives.L'Union européenne (UE) a établi des réglementations spécifiques pour protéger la santé des consommateurs et des niveaux maximaux de 50 g / kg sont fixés pour les jus de fruits et les produits dérivés, 25 g / kg pour les pu

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31

Tannous, Joanna. "Patuline, mycotoxine de Penicillium expansum, principal pathogène post-récolte des pommes : nouvelles données sur sa biosynthèse et développement d'approches préventives." Thesis, Toulouse, INPT, 2015. http://www.theses.fr/2015INPT0030/document.

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La pourriture bleue causée par Penicillium expansum est l'une des maladies les plus dommageables des fruits pomaceae (pommes et poires). Outre des dégâts directs, cette maladie pose un problème de santé publique car l'agent pathogène produit des mycotoxines nocives pour l'homme et les animaux dont la plus sérieuse est la patuline. La croissance du champignon pathogène et la production de patuline requièrent des conditions physico-chimiques particulières. Les informations existantes à ce propos demeurent cependant modestes et insuffisantes pour envisager de développer des moyens de lutte contre

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32

Hong, Soobok Lee. "Genetics and ergoline alkaloid formation in Penicillium roquefortii Thom <= Pt 1> : Biosynthetic studies on ergoline alkaloid production in morning glory plants <= Pt 2> /." Ann Arbor/Mich. : University Microfilms International, 1987. http://www.gbv.de/dms/bs/toc/01657026x.pdf.

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33

Spröte, Petra [Verfasser]. "Regulation and evolution of the penicillin biosynthesis gene cluster of Aspergillus nidulans / von Petra Spröte." 2009. http://d-nb.info/992613892/34.

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34

Henriques, Gabriela Fernandes. "Study of the role of wall teichoic acids in the localization Staphylococcus aureus cell wall synthesis protein PBP4." Master's thesis, 2013. http://hdl.handle.net/10362/16316.

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The cell wall of Staphylococcus aureus is a highly complex network mainly composed of highly cross-linked peptidoglycan (PG) and teichoic acids (TAs), both important for the maintenance of the integrity and viability of bacteria. The penicillin binding proteins (PBPs), which catalyse the final stage of PG biosynthesis, are targets of β-lactam antibiotics and have been a key focus of antibacterial research. S. aureus has four native PBPs, PBP1-4 carried by both methicillin-sensitive (MSSA) and –resistant (MRSA) strains. PBP4 is required for the synthesis of the highly cross-linked PG and, as sh

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35

Brulle, Jan van den. "Klonierung und Charakterisierung von trans-aktiven Faktoren der Penicillin-Biosynthese in Aspergillus nidulans /." 1999. http://www.gbv.de/dms/bs/toc/321617266.pdf.

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36

Harrison, Duncan. "A comparison of the farnesyl pyrophosphate and B-cyclopiazonic acid synthases from penicillium cyclopium." Thesis, 2015. http://hdl.handle.net/10539/16734.

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37

Bacha, Nafees. "Caracterization of the polyketide synthases involved in biosynthesis of ochratoxin A, penicillic acid, asperlactone and isoasperlactone in aspergillus westerdijkiae (a molecular approach)." Phd thesis, 2009. http://oatao.univ-toulouse.fr/7846/1/bacha.pdf.

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Aspergillus westerdijkiaem which is recently dismembered from A. ochraceusm is the principal producer of several economically important polyketide metabolites. These metabolites include ochratoxin A, mellein, penicillic acid, asperlactone and isoasperlactone and some intermediates like orsellinic acid and 6-methylsalicylic acid. The biosynthesis of these metabolites is catalyzed by a group of enzymes known as polyketide synthases (PKSs). This work was aimed to clone and functionally characterized various PKS i.e. aoks1, aolc35-12 and aomsas, and polyketide synthasesnon ribosomal peptide syntha

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38

Saikia, Sanjay. "Functional analysis of Penicillium paxilli genes required for biosynthesis of paxilline : this thesis is presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Biochemistry at Massey University, Palmerston North, New Zealand." 2006. http://hdl.handle.net/10179/1489.

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Paxilline belongs to a large, structurally and functionally diverse group of indole-diterpenes and is synthesised by the filamentous fungus Penicillium paxilli. A gene cluster for paxilline biosynthesis in P. paxilli has been identified and characterised. However, none of the steps proposed in the biosynthesis of paxilline or paxilline-like indole-diterpenes have been validated. In some diterpene-producing filamentous fungi, including P. paxilli, two distinct copies of geranylgeranyl diphosphate (GGPP) synthase, that catalyses the committed step in diterpene biosynthesis, have been identified.

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