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Relevant bibliographies by topics / Pharmacokinetics; Dihydroartemisinin

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Academic literature on the topic 'Pharmacokinetics; Dihydroartemisinin'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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Journal articles on the topic "Pharmacokinetics; Dihydroartemisinin"

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Rijken, Marcus J., Rose McGready, Aung Phae Phyo, et al. "Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Falciparum Malaria." Antimicrobial Agents and Chemotherapy 55, no. 12 (2011): 5500–5506. http://dx.doi.org/10.1128/aac.05067-11.

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ABSTRACTDihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination treatment. Some antimalarials have altered pharmacokinetics in pregnancy. Pregnant women in the 2nd or 3rd trimester and matched nonpregnant women with uncomplicated falciparum malaria were treated with a total of 6.4 mg/kg of body weight dihydroartemisinin and 51.2 mg/kg piperaquine once daily for 3 days. Venous blood samples were drawn at prespecified time points over 9 weeks. Plasma dihydroartemisinin and piperaquine concentrations were analyzed by liquid chromatography-mass spectrometry. Piperaquine and di

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Tarning, Joel, Marcus J. Rijken, Rose McGready, et al. "Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria." Antimicrobial Agents and Chemotherapy 56, no. 4 (2012): 1997–2007. http://dx.doi.org/10.1128/aac.05756-11.

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ABSTRACTPregnant women are particularly vulnerable to malaria. The pharmacokinetic properties of antimalarial drugs are often affected by pregnancy, resulting in lower drug concentrations and a consequently higher risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. Twenty-four pregnant and 24 matched nonpregnant women on the Thai-Myanmar boarder were treated with a standard fixed oral 3-day treatment, and venous plasma concentrations o

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Hanboonkunupakarn, Borimas, Elizabeth A. Ashley, Podjanee Jittamala, et al. "Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects." Antimicrobial Agents and Chemotherapy 58, no. 12 (2014): 7340–46. http://dx.doi.org/10.1128/aac.03704-14.

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ABSTRACTDihydroartemisinin-piperaquine is an artemisinin-based combination treatment (ACT) recommended by the WHO for uncomplicatedPlasmodium falciparummalaria, and it is being used increasingly for resistant vivax malaria where combination with primaquine is required for radical cure. The WHO recently reinforced its recommendations to add a single dose of primaquine to ACTs to reduceP. falciparumtransmission in low-transmission settings. The pharmacokinetics of primaquine and dihydroartemisinin-piperaquine were evaluated in 16 healthy Thai adult volunteers in a randomized crossover study. Vol

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Nyunt, Myaing M., Vy K. Nguyen, Richard Kajubi, et al. "Artemether-Lumefantrine Pharmacokinetics and Clinical Response Are Minimally Altered in Pregnant Ugandan Women Treated for Uncomplicated Falciparum Malaria." Antimicrobial Agents and Chemotherapy 60, no. 3 (2015): 1274–82. http://dx.doi.org/10.1128/aac.01605-15.

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Artemether-lumefantrine is a first-line regimen for the treatment of uncomplicated malaria during the second and third trimesters of pregnancy. Previous studies have reported changes in the pharmacokinetics and clinical outcomes following treatment with artemether-lumefantrine in pregnant women compared to nonpregnant adults; however, the results are inconclusive. We conducted a study in rural Uganda to compare the pharmacokinetics of artemether-lumefantrine and the treatment responses between 30 pregnant women and 30 nonpregnant adults with uncomplicatedPlasmodium falciparummalaria. All parti

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Davis, Timothy M. E., Hoang Lan Phuong, Kenneth F. Ilett, et al. "Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate in Severe Falciparum Malaria." Antimicrobial Agents and Chemotherapy 45, no. 1 (2001): 181–86. http://dx.doi.org/10.1128/aac.45.1.181-186.2001.

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ABSTRACT To provide novel data relating to the dispositions, effects, and toxicities of the artemisinin derivatives in severe malaria, we studied 30 Vietnamese adults with slide-positive falciparum malaria treated with intravenous artesunate. Twelve patients with complications (severe; group 1) and 8 patients without complications but requiring parenteral therapy (moderately severe; group 2) received 120 mg of artesunate by injection, and 10 patients with moderately severe complications (group 3) were given 240 mg by infusion. Serial concentrations of artesunate and its active metabolite dihyd

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Birgersson, Sofia, Innocent Valea, Halidou Tinto, et al. "Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso: an open label trial." Wellcome Open Research 4 (March 7, 2019): 45. http://dx.doi.org/10.12688/wellcomeopenres.14849.1.

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Background: Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial drugs. This might lead to an under-exposure in these patients which could increase the risk of treatment failure and the development of drug resistance. The study aim was to evaluate the pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant patients using a population modelling approach. Methods: Twenty-four women in their second and third trimester of pregnancy and twenty-fo

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Birgersson, Sofia, Innocent Valea, Halidou Tinto, et al. "Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso: an open label trial." Wellcome Open Research 4 (January 10, 2020): 45. http://dx.doi.org/10.12688/wellcomeopenres.14849.2.

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Background: Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial drugs. This might lead to an under-exposure in these patients which could increase the risk of treatment failure and the development of drug resistance. The study aim was to evaluate the pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant patients using a population modelling approach. Methods: Twenty-four women in their second and third trimester of pregnancy and twenty-fo

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Hietala, Sofia Friberg, Andreas Mårtensson, Billy Ngasala, et al. "Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4780–88. http://dx.doi.org/10.1128/aac.00252-10.

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ABSTRACT The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and parasitological cure, increasing exposure to artemether and the active metabolite dihydroartemisinin (DHA) has been shown to decrease the parasite clearance time. The aim of this analysis was to describe the pharmacokinetics and pharmacodynamics of artemether, dihydroartemisinin, and lumefantrine in African children with uncomplicated mala

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Tarning, Joel, Frank Kloprogge, Mehul Dhorda, et al. "Pharmacokinetic Properties of Artemether, Dihydroartemisinin, Lumefantrine, and Quinine in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria in Uganda." Antimicrobial Agents and Chemotherapy 57, no. 10 (2013): 5096–103. http://dx.doi.org/10.1128/aac.00683-13.

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ABSTRACTPregnancy alters the pharmacokinetic properties of many drugs used in the treatment of malaria, usually resulting in lower drug exposures. This increases the risks of treatment failure, adverse outcomes for the fetus, and the development of resistance. The pharmacokinetic properties of artemether and its principal metabolite dihydroartemisinin (n= 21), quinine (n= 21), and lumefantrine (n= 26) in pregnant Ugandan women were studied. Lumefantrine pharmacokinetics in a nonpregnant control group (n= 17) were also studied. Frequently sampled patient data were evaluated with noncompartmenta

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Nguyen, Dao Van Hoang, Quoc Phuc Nguyen, Ngoa Dang Nguyen, et al. "Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam." Antimicrobial Agents and Chemotherapy 53, no. 8 (2009): 3534–37. http://dx.doi.org/10.1128/aac.01717-08.

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ABSTRACT Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.

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Dissertations / Theses on the topic "Pharmacokinetics; Dihydroartemisinin"

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Tan, Bee San Fleckenstein Lawrence L. "Population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/442.

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Tan, Bee San. "Population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/442.

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Artemisinin compounds are the most potent anti-malarial drugs available in the market. Today, malaria treatment is largely relies on the artemisinin-based combination therapies. Artesunate (AS) is the most widely used artemisinin derivative. In this thesis, we characterized the population pharmacokinetics of AS and its active metabolite dihydroartemisinin (DHA) following oral administration of AS in different populations. In Chapter II, we developed a population pharmacokinetic model of AS and DHA in healthy subjects. These subjects received either single- or multiple-dosing of oral AS, as a m

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Awad, Abdelmoneim Ismail. "The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan." Thesis, Robert Gordon University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342746.

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Morris, Carrie Ann. "Population pharmacokinetics of artesunate and dihydroartemisinin in children and pregnant women with malaria." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1367.

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Artemisinin derivatives are key to the current global treatment approach for malaria. However, much remains unknown regarding the pharmacokinetics of these agents, particularly in children and pregnant women, two groups highly vulnerable to development of severe malaria infection. In this thesis, nonlinear mixed effects modeling is used to characterize the pharmacokinetics of the artemisinin derivative artesunate and its active metabolite, dihydoartemisinin (DHA), in children and in pregnant women. Chapter 1 of this thesis contains a general review of the clinical pharmacokinetic findings for

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Kloprogge, Frank Lodewijk. "Pharmacokinetics and pharmacodynamics of antimalarial drugs in pregnant women." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:79ce1a37-3ba2-45e4-9f80-0692a66837f1.

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Malaria is the most important parasitic disease in man and it kills approximately 2,000 people each day. Pregnant women are especially vulnerable to malaria with increased incidence and mortality rates. There are indications that pregnancy alters the pharmacokinetic properties of many antimalarial drugs. This is worrisome as lower drug exposures might result in lowered efficacy and lower drug exposures can also accelerate the development and spread of resistant parasites. The aim of this research was to study the pharmacokinetics and pharmacodynamics of the most commonly used drugs for the tre

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Reports on the topic "Pharmacokinetics; Dihydroartemisinin"

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Idowu, Olutosin R. Support of Study Entitled, Metabolism and Pharmacokinetics of Dihydroartemisinin" and "In Vitro and In Vivo Metabolism of Sodium Artelinate and DQHS in Rats and Humans".". Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada368434.

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